MCID: EPD081
MIFTS: 25

Epidermoid Brain Cyst

Categories: Cancer diseases, Fetal diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Epidermoid Brain Cyst

MalaCards integrated aliases for Epidermoid Brain Cyst:

Name: Epidermoid Brain Cyst 52
Central Nervous System Epidermoid Cyst 52
Intracranial Epidermoid Cyst 52
Epidermoid Brain Tumor 52

Classifications:



Summaries for Epidermoid Brain Cyst

NIH Rare Diseases : 52 Epidermoid brain cysts (also called intracranial epidermoid cysts or tumors ) usually form in the very early stages of the development of a baby (embryo). The cysts develop when cells that are meant to become skin, hair, and nails (epithelial cells) are trapped among the cells that form the brain. Less commonly, the cysts may develop later in life (acquired) when an injury or surgery causes epithelial cells to be trapped in brain tissue . An epidermoid brain cyst has a thin outer layer of epithelial cells surrounding fluid, keratin , and cholesterol . Although epidermoid brain cysts are usually benign (not cancerous) and slow growing, the cysts may grow around and encase cranial nerves and arteries . Thus, epidermoid brain cysts are most often diagnosed in middle-aged adults when the cysts have grown large enough to cause symptoms. Symptoms may include hearing loss , ringing in the ears (tinnitus ), headaches, involuntary twitching of the face, or chronic, severe face pain (trigeminal neuralgia ). Rarely, an epidermoid cyst may leak into surrounding tissue and cause the lining of the brain (meninges ) to become inflamed (aseptic meningitis , meaning the meningitis is not caused by a virus or bacteria ). Epidermoid brain cysts may be diagnosed by MRI and CT scans . Treatment usually involves surgery. Complete removal may be difficult if the cysts have surrounded or are very close to cranial nerves, arteries, or brain tissue. Regrowth of the cysts may occur, but in most cases, due to slow growth, symptoms may not return for years. If aseptic meningitis develops due to leakage of the cyst, steroids may be used to control the inflammation. There have been some reports of existing cysts or remnants of cysts left behind after surgery developing into cancer (since the cyst is made of skin cells, the cancer is usually a form of skin cancer, most commonly squamous cell carcinoma).

MalaCards based summary : Epidermoid Brain Cyst, also known as central nervous system epidermoid cyst, is related to aseptic meningitis and hydrocephalus. Affiliated tissues include brain, skin and pineal.

Wikipedia : 74 Intracranial epidermoid cysts develop in the early embryonic phases. The cysts develop when epithelial... more...

Related Diseases for Epidermoid Brain Cyst

Diseases related to Epidermoid Brain Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 10.3
2 hydrocephalus 10.3
3 trigeminal neuralgia 10.3
4 epidermoid cysts 10.2
5 arachnoid cysts, intracranial 10.1
6 ataxia and polyneuropathy, adult-onset 10.1
7 benign teratoma 10.1
8 cholesteatoma of middle ear 10.1
9 squamous cell carcinoma 10.1
10 cystic teratoma 10.1
11 vestibular disease 10.1
12 mature teratoma 10.1
13 meningitis 10.1
14 hemifacial spasm, familial 10.0
15 ptosis 10.0
16 facial paralysis 10.0
17 obstructive hydrocephalus 10.0
18 papilledema 10.0
19 communicating hydrocephalus 10.0
20 glioblastoma multiforme 10.0
21 neurilemmoma 10.0
22 germinoma 10.0
23 teratoma 10.0
24 cranial nerve palsy 10.0
25 craniopharyngioma 10.0
26 eating disorder 10.0
27 intracranial hypertension 10.0
28 head injury 10.0
29 hemifacial spasm 10.0
30 syncope 10.0
31 syringohydromyelia 10.0
32 rare tumor 10.0

Graphical network of the top 20 diseases related to Epidermoid Brain Cyst:



Diseases related to Epidermoid Brain Cyst

Symptoms & Phenotypes for Epidermoid Brain Cyst

Drugs & Therapeutics for Epidermoid Brain Cyst

Search Clinical Trials , NIH Clinical Center for Epidermoid Brain Cyst

Genetic Tests for Epidermoid Brain Cyst

Anatomical Context for Epidermoid Brain Cyst

MalaCards organs/tissues related to Epidermoid Brain Cyst:

40
Brain, Skin, Pineal

Publications for Epidermoid Brain Cyst

Articles related to Epidermoid Brain Cyst:

(show top 50) (show all 62)
# Title Authors PMID Year
1
Intracranial white epidermoid cyst with dystrophic calcification - A case report and literature review. 61 52
28342703 2017
2
Mixed Signal Intensity on Preoperative T1 MRI Might be Associated with Delayed Postoperative Hemorrhage in Patients with Intracranial Epidermoid Cyst. 61
31493609 2020
3
Proton beam therapy for malignant transformation of intracranial epidermoid cyst. 61
31320371 2019
4
Intracranial Squamous Cell Carcinoma Arising From a Cerebellopontine Angle Epidermoid Cyst Remnant Four Decades After Partial Resection. 61
31428577 2019
5
Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report. 61
30543115 2018
6
A Frontal Giant Intradiploic Giant Pearl (Epidermoid Cyst) With Intracranial and Extracranial Extension: A Rare Entity. 61
30937095 2018
7
Intracranial epidermoid cyst with proliferative folliculosebaceous epithelium: Report of a rare case and discussion on pathogenesis. 61
29876981 2018
8
Fulminant leptomeningeal carcinomatosis from a malignant melanoma arising in a cerebellopontine epidermoid cyst: A rare case with diagnostic pointers. 61
29876986 2018
9
Ultrastructure of Pericystic or Intracystic Blood Vessels in Epidermoid Cysts-A Transmission Electron Microscopy Study: Laboratory Investigation. 61
28427981 2017
10
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst. 61
27793056 2017
11
Malignant transformation of a residual cerebellopontine angle epidermoid cyst. 61
27519146 2016
12
Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis. 61
27123070 2016
13
A case report of spontaneous rupture of intracranial epidermoid cyst with dramatic increase of serum carbohydrate antigen 199: a three-year follow-up study. 61
26458877 2015
14
[Application of brain diffusion-weighted imaging performed using readout segmentation of long variable echo trains]. 61
25557097 2015
15
Hemorrhagic Epidermoid Cyst in Cerebellar Vermis. 61
26442558 2015
16
Malignant transformation of intracranial epidermoid cyst. 61
24345076 2014
17
Spontaneous regression of an epidermoid cyst of the cavernous sinus. 61
24736191 2014
18
Surgical treatment of an intracranial epidermoid cyst in a dog. 61
22759067 2012
19
Germinoma occurring 2 years after total resection of an intracranial epidermoid cyst in the pineal region. 61
21874384 2012
20
Malignant transformation six months after removal of intracranial epidermoid cyst: a case report. 61
22937343 2011
21
Natural malignant transformation of an intracranial epidermoid cyst. 61
20497873 2010
22
Malignant transformation of an intracranial large epidermoid cyst with leptomeningeal carcinomatosis: case report. 61
20448435 2010
23
Malignant transformation 20 years after partial removal of intracranial epidermoid cyst--case report. 61
20339276 2010
24
Recurrent epidermoid cyst with malignant transformation into squamous cell carcinoma. 61
19779295 2009
25
Intracranial epidermoid cyst: magnetic resonance imaging features. 61
19587491 2009
26
[Intracranial epidermoid cyst secondary to mucocele surgery]. 61
19308010 2009
27
Intracranial epidermoid cyst: case report. 61
19354040 2008
28
Imaging diagnosis--intracranial epidermoid cyst in a Doberman Pinscher. 61
17508513 2007
29
Intracranial epidermoid cyst and syringohydromyelia in a dog. 61
16863050 2006
30
Epidermoid cyst with infiltrative malignant melanoma in the cerebellopontine angle. 61
16815016 2006
31
Early recurrence of an intracranial epidermoid cyst due to low-grade infection: case report. 61
17077875 2006
32
Intracranial epidermoid cyst with hemorrhage: MR imaging findings. 61
16484424 2006
33
[MRI manifestation of brain squamous cell carcinoma followed by Intracranial epidermoid cyst--a case report ]. 61
16061012 2005
34
[Spontaneously hyperdense intracranial epidermoid cyst]. 61
15094655 2004
35
Malignant transformation of intracranial epidermoid cyst with leptomeningeal carcinomatosis: case report. 61
15008508 2003
36
Intracranial epidermoid cyst in a horse. 61
12859913 2003
37
[Surgery of intracranial epidermoid cysts. Report of 44 patients and review of the literature]. 61
11972145 2002
38
Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst. 61
11606346 2001
39
Leptomeningeal metastasis from an intracranial epidermoid cyst. 61
11376208 2001
40
Bilateral papilledema from a massive intracranial epidermoid cyst. 61
11004312 2000
41
Hyperdense intracranial epidermoid: an uncommon presentation. 61
10878781 2000
42
Canine intracranial epidermoid cyst. 61
10528837 1999
43
Intracranial epidermoid cyst including elements of old hematoma. 61
9414932 1997
44
Hemorrhage in intracranial epidermoid cyst. 61
9064010 1996
45
Recurrent intracranial epidermoid cyst treated with radiotherapy. 61
7595760 1995
46
Post-traumatic epidermoid cyst: CT appearance. 61
7822537 1995
47
Long-term evaluation of asymptomatic patients operated on for intracranial epidermoid cysts. Comparison of the diagnostic value of magnetic resonance imaging and computer-assisted cisternography for detection of cholesterin fragments. 61
7847127 1994
48
Neuroradiological features of patients with optic nerve hypoplasia. 61
1588471 1992
49
A case of multiloculated, intracranial epidermoid cyst in a beagle dog. 61
1921319 1991
50
Recurrent aseptic meningitis secondary to intracranial epidermoid cyst and Mollaret's meningitis: two distinct entities or a single disease? A case report and a nosologic discussion. 61
2252049 1990

Variations for Epidermoid Brain Cyst

Cosmic variations for Epidermoid Brain Cyst:

9 (show top 50) (show all 1388)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87910628 TP53 skin,face,carcinoma,squamous cell carcinoma c.772G>A p.E258K 17:7674191-7674191 4
2 COSM87910495 TP53 skin,face,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 4
3 COSM87904406 TP53 skin,ear,carcinoma,squamous cell carcinoma c.796G>A p.G266R 17:7673824-7673824 4
4 COSM87910722 TP53 skin,ear,carcinoma,squamous cell carcinoma c.764T>G p.I255S 17:7674199-7674199 4
5 COSM87899887 TP53 skin,ear,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 4
6 COSM87905569 TP53 skin,face,carcinoma,squamous cell carcinoma c.740A>C p.N247T 17:7674223-7674223 4
7 COSM87899145 TP53 skin,face,carcinoma,squamous cell carcinoma c.763A>T p.I255F 17:7674200-7674200 4
8 COSM87899377 TP53 skin,face,carcinoma,squamous cell carcinoma c.375+1G>A p.? 17:7675993-7675993 4
9 COSM88137274 TP53 skin,ear,carcinoma,squamous cell carcinoma c.988C>T p.L330F 17:7673540-7673540 4
10 COSM87897627 TP53 skin,face,carcinoma,squamous cell carcinoma c.574C>T p.Q192* 17:7674957-7674957 4
11 COSM87917387 TP53 skin,face,carcinoma,squamous cell carcinoma c.746G>C p.R249T 17:7674217-7674217 4
12 COSM87970671 TP53 skin,face,carcinoma,squamous cell carcinoma c.766A>C p.T256P 17:7674197-7674197 4
13 COSM87961721 TP53 skin,ear,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 17:7674261-7674261 4
14 COSM87899395 TP53 skin,ear,carcinoma,squamous cell carcinoma c.824G>T p.C275F 17:7673796-7673796 4
15 COSM87906137 TP53 skin,face,carcinoma,squamous cell carcinoma c.260C>A p.P87Q 17:7676109-7676109 4
16 COSM87991360 TP53 skin,face,carcinoma,squamous cell carcinoma c.714T>A p.C238* 17:7674249-7674249 4
17 COSM87961289 TP53 skin,face,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 4
18 COSM87898463 TP53 skin,face,carcinoma,squamous cell carcinoma c.733G>T p.G245C 17:7674230-7674230 4
19 COSM88236209 RPTOR skin,ear,carcinoma,squamous cell carcinoma c.8C>A p.S3Y 17:80545637-80545637 4
20 COSM139854076 PTPRS skin,ear,carcinoma,squamous cell carcinoma c.5600A>C p.K1867T 19:5208279-5208279 4
21 COSM90829299 PTCH1 skin,face,carcinoma,squamous cell carcinoma c.3724G>A p.E1242K 9:95449149-95449149 4
22 COSM97108079 NRAS skin,face,carcinoma,squamous cell carcinoma c.183A>T p.Q61H 1:114713907-114713907 4
23 COSM97110803 NRAS skin,face,carcinoma,squamous cell carcinoma c.443C>T p.T148I 1:114709576-114709576 4
24 COSM97107717 NRAS skin,face,carcinoma,squamous cell carcinoma c.38G>T p.G13V 1:114716123-114716123 4
25 COSM88407030 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5836A>G p.T1946A 1:119918499-119918499 4
26 COSM88391473 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.6607A>G p.N2203D 1:119916115-119916115 4
27 COSM88396973 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5449G>A p.D1817N 1:119920259-119920259 4
28 COSM88403804 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.3511T>C p.Y1171H 1:119937293-119937293 4
29 COSM88388711 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.337C>T p.R113* 1:120005407-120005407 4
30 COSM88409975 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5524T>C p.S1842P 1:119919569-119919569 4
31 COSM88399925 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.7097C>T p.A2366V 1:119915625-119915625 4
32 COSM88404240 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5141G>A p.G1714D 1:119922308-119922308 4
33 COSM88396449 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.2504C>T p.A835V 1:119949102-119949102 4
34 COSM88389161 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.2987G>A p.C996Y 1:119940751-119940751 4
35 COSM88409965 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5524T>A p.S1842T 1:119919569-119919569 4
36 COSM88409980 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.1060A>G p.I354V 1:119969559-119969559 4
37 COSM88404245 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5140G>A p.G1714S 1:119922309-119922309 4
38 COSM88394293 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.2414T>C p.L805P 1:119950789-119950789 4
39 COSM88394286 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5266G>A p.E1756K 1:119921757-119921757 4
40 COSM88402034 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5006A>G p.E1669G 1:119922443-119922443 4
41 COSM88393640 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5942T>C p.L1981P 1:119917750-119917750 4
42 COSM88393645 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.2602C>G p.Q868E 1:119948564-119948564 4
43 COSM88394358 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.2839C>T p.Q947* 1:119941668-119941668 4
44 COSM88403799 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.3697C>T p.P1233S 1:119929171-119929171 4
45 COSM88406288 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.1378T>C p.C460R 1:119967508-119967508 4
46 COSM88406270 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.3578A>G p.N1193S 1:119935549-119935549 4
47 COSM88404251 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.2314T>C p.C772R 1:119953594-119953594 4
48 COSM88402024 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.5468T>C p.V1823A 1:119920240-119920240 4
49 COSM88407035 NOTCH2 skin,face,carcinoma,squamous cell carcinoma c.2234G>A p.C745Y 1:119953674-119953674 4
50 COSM88391488 NOTCH2 skin,ear,carcinoma,squamous cell carcinoma c.4708G>A p.G1570S 1:119923788-119923788 4

Expression for Epidermoid Brain Cyst

Search GEO for disease gene expression data for Epidermoid Brain Cyst.

Pathways for Epidermoid Brain Cyst

GO Terms for Epidermoid Brain Cyst

Sources for Epidermoid Brain Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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