MCID: EPD070
MIFTS: 42

Epidermoid Cysts

Categories: Skin diseases
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Aliases & Classifications for Epidermoid Cysts

MalaCards integrated aliases for Epidermoid Cysts:

Name: Epidermoid Cysts 57
Epidermoid Cyst 53 75 33
Epidermal Inclusion Cyst 33
Sebaceous Cyst 33
Epidermal Cyst 33

Characteristics:


Inheritance:

Autosomal dominant 57

Classifications:



Summaries for Epidermoid Cysts

MalaCards based summary: Epidermoid Cysts, also known as epidermoid cyst, is related to cutaneous fibrous histiocytoma and psoriasis 7. An important gene associated with Epidermoid Cysts is S100A1 (S100 Calcium Binding Protein A1), and among its related pathways/superpathways are Keratinization and Vitamin D receptor pathway. The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, spleen and testis, and related phenotypes are abnormality of the skin and epidermoid cyst

Wikipedia: 75 An epidermoid cyst or epidermal inclusion cyst is a benign cyst usually found on the skin. The cyst... more...

More information from OMIM: 131600

Related Diseases for Epidermoid Cysts

Diseases related to Epidermoid Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)
# Related Disease Score Top Affiliating Genes
1 cutaneous fibrous histiocytoma 30.2 S100B S100A1
2 psoriasis 7 30.1 S100A5 S100A3
3 glomus tumor 30.0 S100B S100A1
4 germinoma 30.0 CGB3 APC
5 syringoma 29.9 S100B S100A1
6 granular cell tumor 29.9 S100B S100A1
7 steatocystoma multiplex 29.9 KRT6A KRT17
8 basal cell carcinoma 29.6 TCHH S100A2 KRT17 IVL
9 keratosis 29.6 TCHH KRT17 IVL
10 keratosis, seborrheic 29.5 KRT17 IVL
11 meningioma, familial 29.5 S100B S100A6 S100A5 APC
12 pachyonychia congenita 1 29.3 KRT6A KRT17 IVL
13 pilomatrixoma 29.0 TCHH S100B S100A6 S100A3 S100A2 KRT17
14 skin disease 28.6 TCHH KRT6A KRT17 IVL APC
15 pituitary dermoid and epidermoid cysts 11.4
16 familial adenomatous polyposis 1 11.3
17 follicular atrophoderma, perioral pigmented, with milia and epidermoid cysts 11.2
18 basaloid follicular hamartoma 11.1
19 dermoid or epidermoid cyst of the central nervous system 11.1
20 teratoma 10.5
21 benign teratoma 10.4
22 dermoid cyst of ovary 10.4
23 trigeminal neuralgia 10.3
24 testicular cancer 10.3
25 aseptic meningitis 10.3
26 ptosis 10.3
27 arachnoid cysts, intracranial 10.3
28 hydrocephalus 10.3
29 conjunctival intraepithelial neoplasm 10.3 S100A2 S100A1
30 molluscum contagiosum 10.3
31 basal cell carcinoma 1 10.3
32 paraplegia 10.2
33 cholesteatoma of middle ear 10.2
34 pancreatic cancer 10.2
35 urinary tract infection 10.2
36 splenomegaly 10.2
37 paresthesia 10.2
38 adenoma 10.2
39 intracranial hypertension 10.2
40 germ cell tumor 10.2
41 breast cyst 10.1
42 hemangioma 10.1
43 chondroblastoma 10.1 S100A2 S100A1
44 bone cancer 10.1
45 myiasis 10.1
46 meningocele 10.1
47 mucocele of salivary gland 10.1
48 communicating hydrocephalus 10.1
49 squamous cell carcinoma 10.1
50 calcinosis 10.1

Graphical network of the top 20 diseases related to Epidermoid Cysts:



Diseases related to Epidermoid Cysts

Symptoms & Phenotypes for Epidermoid Cysts

Human phenotypes related to Epidermoid Cysts:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the skin 30 HP:0000951
2 epidermoid cyst 30 HP:0200040

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Skin:
epidermoid cysts

Clinical features from OMIM®:

131600 (Updated 08-Dec-2022)

Drugs & Therapeutics for Epidermoid Cysts

Drugs for Epidermoid Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 4
3 Sodium Channel Blockers Phase 4
4 Anesthetics, Local Phase 4
5 Anesthetics Phase 4
6 Diuretics, Potassium Sparing Phase 4
7
Sodium tetradecyl sulfate Approved, Investigational Phase 2 1191-50-0, 139-88-8 5248
8 Pharmaceutical Solutions Phase 2
9 Sclerosing Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Completed NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 Comparison of Excision Versus Punch Incision in the Treatment of Epidermal Cysts Completed NCT00165958 Phase 4
3 A Prospective Clinical Trial Evaluating the Efficacy of 1.5% Sodium Tetradecyl Sulfate Foam Injection for the Treatment of Epidermoid Cysts Not yet recruiting NCT05597995 Phase 2 Sodium Tetradecyl Sulfate
4 Atypical Intraorbital Dermoid and Epidermoid Cyst: A Single Institution Cross-sectional Retrospective Study Completed NCT05410431
5 Computer Aided Tool for Diagnosis of Neck Masses in Children Recruiting NCT05187923

Search NIH Clinical Center for Epidermoid Cysts

Genetic Tests for Epidermoid Cysts

Anatomical Context for Epidermoid Cysts

Organs/tissues related to Epidermoid Cysts:

MalaCards : Skin, Spleen, Testis, Spinal Cord, Pineal, Breast, Bone

Publications for Epidermoid Cysts

Articles related to Epidermoid Cysts:

(show top 50) (show all 3986)
# Title Authors PMID Year
1
Could APC gene screening be useful in children with hepatoblastoma? Early onset of adenocarcinoma in a child with familial adenomatous polyposis and hepatoblastoma. 53 62
20210251 2009
2
Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis. 53 62
15888153 2005
3
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 53 62
15287021 2004
4
Differential expression of S100 calcium-binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas. 53 62
12653951 2003
5
Falsely increased beta-human chorionic gonadotropin with a testicular epidermoid cyst. 53 62
11696768 2001
6
Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. 53 62
9185910 1997
7
Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene. 53 62
7485167 1995
8
Epidermoid cyst of the spleen: a cytokeratin profile with comparison to other squamous epithelia. 53 62
7514079 1994
9
An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies. 53 62
1701984 1990
10
Epidermal Cyst Mimicking Thyroid Cancer Metastasis. 62
36469062 2023
11
Rapid malignant transformation of an intracranial epidermoid cyst: Report of a case. 62
36464491 2022
12
Atypical presentation of a subungual intraosseous epidermoid cyst of the thumb: A case report. 62
36155831 2022
13
Establishment and Verification of a Prediction Model for Identifying Pathologic Infections Based on the Clinical Characteristics of Epidermoid Cysts. 62
36374320 2022
14
Assessment of epidermoid cyst with trigeminal neuralgia before neuroendoscopy: A high-resolution MR study based on 3D-FIESTA and MR angiography. 62
35973272 2022
15
Epidermoid Cyst of the Floor of the Mouth. 62
34980839 2022
16
Intracranial "white" epidermoid tumours - An imaging approach and systematic review. 62
35961175 2022
17
Epidermoid cyst of the cerebellar vermis: Case report of a rare medial topography. 62
36120520 2022
18
Imaging of intraspinal cystic lesions: A review. 62
35942824 2022
19
Intraoperative high-field resonance: How to optimize its use in our healthcare system. 62
34625382 2022
20
Synchronous ovarian epidermoid cyst torsion with appendicitis in a 2.5-year-old girl: Case report. 62
36242891 2022
21
Diffuse Large B-cell Lymphoma Presenting as an "Oops" Lesion in the Nasolabial Fold: A Case Report. 62
36437728 2022
22
Fetal Orbital Epidermal Cyst Pre-Postnatal Imaging Findings: A Case Report and Literature Review. 62
36453487 2022
23
Stage T3 Squamous Cell Carcinoma Misdiagnosed as an Epidermal Inclusion Cyst. 62
36095254 2022
24
The reproducibility of shear wave and strain elastography in epidermal cysts. 62
36195316 2022
25
Epidermal inclusion cyst in male breast: how to differentiate from other male breast lesions. 62
36032200 2022
26
Nonneoplastic and noninfective cysts of the central nervous system: A histopathological study. 62
36210745 2022
27
Benign Pilomatricoma With Osseous Metaplasia: A Rare Case. 62
36311481 2022
28
Primary squamous cell carcinoma of liver. First case report from Pakistan and South Asia. 62
36126461 2022
29
Prepubertal-Type Testicular Tumors in Postpubertal Patients: Epidermoid Cyst and Well-Differentiated Neuroendocrine Tumor. 62
36202503 2022
30
Intracranial Epidermoid Cyst Mimics Musculoskeletal Shoulder Disease: Findings from a Case Report in Physiotherapy Clinical Practice. 62
36294171 2022
31
Large Unruptured Perineal Epidermoid Cyst: A Rare Case. 62
36381860 2022
32
[Neuroendocrine tumor associated with an intestinal cyst: a case report]. 62
36154737 2022
33
Perirectal epidermoid cyst in a patient with sacrococcygeal scoliosis and anal sinus: A case report. 62
36338219 2022
34
[Imaging findings in cranial and spinal epidermoid cysts]. 62
36252572 2022
35
Rare Giant Infected Intradiploic Skull Epidermoid Cysts. 62
36299917 2022
36
Epidermoid cyst in ureter: A case report. 62
36123920 2022
37
Intraspinal Epidermoid Cyst with Calcification: A Case Report. 62
36348675 2022
38
A Hole in the Head: An Intradiploic Epidermoid Cyst With A Calvarial Defect. 62
36054060 2022
39
Combined Exoscopic- and Endoscopic-Assisted Resection of an Interpeduncular and Middle Fossa Epidermoid Cyst via a Transcavernous Approach: Technical Note. 62
36096388 2022
40
Clinical image-postpartum clitoral epidermoid cyst. 62
35380211 2022
41
Perianal sinus as a unique presentation of a recurrent presacral epidermoid cyst. 62
35005826 2022
42
MRI findings of benign tumors and tumor-like diseases of the tongue with radiologic-pathologic correlation. 62
36097236 2022
43
Epidermal Inclusion Cyst of the Clitoris: A Case Report. 62
36133501 2022
44
Ultrasonographic and strain elastographic features of epidermal cyst according to body location. 62
36172630 2022
45
Atypical Presentation of Epidermoid Inclusion Cyst in a 60-Year-Old Female: A Case Report. 62
36324344 2022
46
Paleopathology of the skull of Santorio Santorio, father of modern clinical experimental physiology. 62
36163303 2022
47
Epidermal cyst formation of the lip following autologous fat transplant. 62
35937544 2022
48
Microcystic adnexal carcinoma misdiagnosed as a "recurrent epidermal cyst": A case report. 62
36158483 2022
49
Case report: Axilla fibroadenoma - An atypical presentation. 62
36045822 2022
50
Subtotal Petrosectomy With Preservation of Chorda Tympani for Petrous Bone Cholesteatoma: Case Report. 62
33064026 2022

Variations for Epidermoid Cysts

Expression for Epidermoid Cysts

Search GEO for disease gene expression data for Epidermoid Cysts.

Pathways for Epidermoid Cysts

Pathways related to Epidermoid Cysts according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 TCHH KRT6A KRT17 IVL
2 11.6 S100A6 S100A4 S100A2
3 11.02 S100B S100A6 S100A4 S100A1

GO Terms for Epidermoid Cysts

Cellular components related to Epidermoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.1 TCHH KRT17 IVL

Biological processes related to Epidermoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.43 TCHH KRT6A KRT17
2 morphogenesis of an epithelium GO:0002009 9.33 KRT6A KRT17
3 keratinization GO:0031424 9.23 TCHH KRT6A KRT17 IVL

Molecular functions related to Epidermoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 10.06 S100A1 S100A2 S100A3 S100A4 S100A5 S100A6
2 S100 protein binding GO:0044548 9.73 S100B S100A6 S100A1
3 RAGE receptor binding GO:0050786 9.62 S100B S100A4
4 transition metal ion binding GO:0046914 9.56 TCHH S100A5 S100A4 S100A3 S100A2
5 calcium-dependent protein binding GO:0048306 9.47 S100B S100A6 S100A5 S100A4 S100A3 S100A2

Sources for Epidermoid Cysts

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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