MCID: EPD004
MIFTS: 26

Epidermolytic Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Epidermolytic Acanthoma

MalaCards integrated aliases for Epidermolytic Acanthoma:

Name: Epidermolytic Acanthoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4323
NCIt 50 C27516
SNOMED-CT 67 733892008
UMLS 70 C1333414

Summaries for Epidermolytic Acanthoma

MalaCards based summary : Epidermolytic Acanthoma is related to clear cell acanthoma and autosomal dominant epidermolytic ichthyosis. An important gene associated with Epidermolytic Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, bone and lung.

Wikipedia : 73 Epidermolytic acanthomas are a cutaneous condition characterized by discrete keratotic papules in... more...

Related Diseases for Epidermolytic Acanthoma

Diseases related to Epidermolytic Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 31.6 KRT10 IVL
2 autosomal dominant epidermolytic ichthyosis 31.2 KRT10 KRT1
3 acanthoma 31.0 TCHH KRT10 KRT1 CDKN2A
4 keratosis 30.4 KRT9 KRT10 KRT1 IVL CDKN2A
5 ichthyosis bullosa of siemens 30.3 KRT2 KRT10 KRT1
6 epidermolytic hyperkeratosis 30.2 TCHH KRT9 KRT2 KRT10 KRT1 IVL
7 ichthyosis 30.2 KRT2 KRT10 KRT1 IVL
8 porokeratosis 30.1 TCHH KRT1 IVL
9 keratosis, seborrheic 30.0 TCHH KRT10 IVL CDKN2A
10 nevus, epidermal 30.0 KRT2 KRT10 KRT1 IVL
11 skin disease 29.9 TCHH KRT9 KRT10 KRT1 IVL
12 verruciform xanthoma of skin 29.4 MSR1 CTSB CD68
13 basal cell carcinoma 29.0 TCHH KRT10 KRT1 IVL CDKN2A CD68
14 erythroderma, ichthyosiform, congenital reticular 10.3 KRT10 KRT1
15 striate palmoplantar keratoderma 10.3 KRT10 KRT1
16 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.3 KRT10 KRT1
17 large cell acanthoma 10.2 TCHH KRT10
18 acrokeratoderma, hereditary papulotranslucent 10.2 KRT9 KRT1
19 diffuse palmoplantar keratoderma 10.2 KRT9 KRT1
20 eccrine papillary adenoma 10.2 KRT9 KRT10
21 steatocystoma multiplex 10.2 KRT2 KRT10
22 skin papilloma 10.2 KRT10 KRT1
23 inverted follicular keratosis 10.2
24 bowen's disease 10.2 KRT10 IVL
25 hair follicle neoplasm 10.2 TCHH KRT10
26 palmoplantar keratoderma, nonepidermolytic 10.2 KRT9 KRT1
27 white sponge nevus 1 10.2 KRT2 KRT1
28 discoid lupus erythematosus 10.2 KRT10 IVL
29 palmoplantar keratoderma, nonepidermolytic, focal 1 10.2 KRT9 KRT2
30 epidermoid cysts 10.2 TCHH IVL
31 keratinopathic ichthyosis 10.1 KRT2 KRT10 KRT1
32 hyaline fibromatosis syndrome 10.1 TCHH KRT10
33 verrucous carcinoma 10.1 KRT10 CDKN2A
34 epidermolysis bullosa dystrophica 10.1 KRT1 IVL
35 cystic teratoma 10.1 KRT10 CDKN2A
36 palmoplantar keratosis 10.1 KRT9 KRT10 KRT1
37 pulmonary artery leiomyosarcoma 10.1 KRT10 CD68
38 ichthyosis vulgaris 10.1 KRT10 KRT1 IVL
39 anus cancer 10.1
40 molluscum contagiosum 10.1
41 posttransplant acute limbic encephalitis 10.1
42 epidermolysis bullosa 10.1 KRT10 KRT1 IVL
43 keratoacanthoma 10.1 KRT10 IVL
44 lichen planus 10.1 KRT10 KRT1 IVL
45 cervical intraepithelial neoplasia 10.1 IVL CDKN2A
46 epidermolysis bullosa simplex 10.1 KRT10 KRT1 IVL
47 inflamed seborrheic keratosis 10.1 TCHH CD68
48 ichthyosis, congenital, autosomal recessive 4b 10.1 KRT2 KRT1 IVL
49 histiocytic sarcoma 10.0 CDKN2A CD68
50 pancreas sarcoma 10.0 CDKN2A CD68

Graphical network of the top 20 diseases related to Epidermolytic Acanthoma:



Diseases related to Epidermolytic Acanthoma

Symptoms & Phenotypes for Epidermolytic Acanthoma

Drugs & Therapeutics for Epidermolytic Acanthoma

Search Clinical Trials , NIH Clinical Center for Epidermolytic Acanthoma

Genetic Tests for Epidermolytic Acanthoma

Anatomical Context for Epidermolytic Acanthoma

MalaCards organs/tissues related to Epidermolytic Acanthoma:

40
Skin, Bone, Lung, Pancreas

Publications for Epidermolytic Acanthoma

Articles related to Epidermolytic Acanthoma:

(show all 50)
# Title Authors PMID Year
1
Epidermolytic Acanthoma: Findings of a Large Retrospective Study. 61
33290356 2021
2
Epidermolytic acanthoma in a young woman: a case letter. 61
33040803 2020
3
Epidermolytic acanthoma: A case report. 61
33024766 2020
4
Mutations in KRT10 in epidermolytic acanthoma. 61
32045015 2020
5
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 61
30480645 2020
6
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 61
31078506 2019
7
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
8
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 61
30663082 2019
9
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. 61
31700841 2019
10
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 61
29090469 2018
11
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. 61
28868008 2017
12
[Multiple epidermolytic acanthomas of the genitalia]. 61
27789051 2017
13
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. 61
26945829 2016
14
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 61
27034569 2016
15
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. 61
26825163 2016
16
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? 61
26512188 2015
17
Multiple localized epidermolytic acanthomas of the vulva associated with vulvar pruritus: a case report. 61
25051105 2015
18
Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment. 61
24703270 2014
19
Solitary epidermolytic acanthoma. 61
23710687 2013
20
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. 61
23083445 2013
21
Isolated epidermolytic acanthoma in a renal transplant recipient. 61
21909223 2011
22
Solitary epidermolytic acanthoma: a clinical and histopathological study. 61
20553361 2011
23
Epidermolytic acanthoma of the scrotum: A rare mimicker of condyloma acuminatum. 61
21272497 2011
24
Linear epidermolytic acanthoma or adult-onset verrucous epidermal nevus? 61
20827001 2010
25
[Disseminated epidermolytic acanthoma]. 61
20620581 2010
26
Linear epidermolytic acanthoma of vulva: an unusual presentation. 61
20061731 2010
27
Multiple epidermolytic acanthomas must not be confused with genital human papillomavirus infection. 61
19326003 2009
28
Porokeratoma. 61
18043046 2007
29
Loop-mediated isothermal amplification method for detection of human papillomavirus type 6, 11, 16, and 18. 61
17385684 2007
30
Granular parakeratotic acanthoma. 61
16148407 2005
31
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature. 61
16043921 2005
32
Multiple spreading epidermolytic acanthomas of the genital and perigenital skin. 61
16088164 2005
33
Multiple scrotal epidermolytic acanthomas; secondary to trauma? 61
15347332 2004
34
Disseminated epidermolytic acanthoma probably related to trauma. 61
10583127 1999
35
[Disseminated epidermolytic acanthoma]. 61
9441167 1997
36
Epidermolytic hyperkeratosis in the lower female genital tract: an uncommon simulant of mucocutaneous papillomavirus infection--a report of two cases. 61
9100071 1997
37
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. 61
8537558 1995
38
Isolated dyskeratotic acanthoma. A variant of isolated epidermolytic acanthoma. 61
7695013 1995
39
Disseminated epidermolytic acanthoma. 61
8434736 1993
40
Epidermolytic acanthoma does not contain human papillomavirus DNA. 61
1649846 1991
41
Acantholytic acanthoma. 61
2461398 1988
42
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. 61
3743846 1986
43
Disseminated epidermolytic acanthoma revealed by PUVA. 61
3770261 1986
44
The benign acanthomas. 61
3160731 1985
45
[Case of isolated epidermolytic acanthoma--special reference to electron microscopic observation of virus like particles]. 61
6676501 1983
46
Disseminated epidermolytic acanthoma. 61
500873 1979
47
Isolated epidermolytic acanthoma. A histological study. 61
478041 1979
48
Disseminated epidermolytic acanthoma. Nonsystematized multiple verrucoid lesions showing granular degeneration. 61
4127475 1973
49
[Solitary epidermolytic acanthoma]. 61
4112013 1972
50
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. 61
5413257 1970

Variations for Epidermolytic Acanthoma

Expression for Epidermolytic Acanthoma

Search GEO for disease gene expression data for Epidermolytic Acanthoma.

Pathways for Epidermolytic Acanthoma

Pathways related to Epidermolytic Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 TCHH KRT9 KRT2 KRT10 KRT1 IVL
2
Show member pathways
11.56 TCHH KRT9 KRT2 KRT10 KRT1 IVL
3 10.76 MSR1 CCR2
4 10.36 MSR1 CD68

GO Terms for Epidermolytic Acanthoma

Cellular components related to Epidermolytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.81 TCHH MSR1 KRT9 KRT2 KRT10 KRT1
2 extracellular exosome GO:0070062 9.73 KRT9 KRT2 KRT10 KRT1 IVL CTSB
3 intermediate filament GO:0005882 9.26 KRT9 KRT2 KRT10 KRT1
4 cornified envelope GO:0001533 9.02 TCHH KRT2 KRT10 KRT1 IVL

Biological processes related to Epidermolytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide cross-linking GO:0018149 9.46 IVL KRT1 KRT10 KRT2
2 intermediate filament organization GO:0045109 9.43 KRT2 KRT9 TCHH
3 keratinization GO:0031424 9.43 IVL KRT1 KRT10 KRT2 KRT9 TCHH
4 keratinocyte differentiation GO:0030216 9.4 IVL KRT10
5 protein heterotetramerization GO:0051290 9.37 KRT1 KRT10
6 positive regulation of epidermis development GO:0045684 9.32 KRT10 KRT2
7 cornification GO:0070268 9.1 IVL KRT1 KRT10 KRT2 KRT9 TCHH

Molecular functions related to Epidermolytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of epidermis GO:0030280 8.8 KRT2 KRT10 KRT1

Sources for Epidermolytic Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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