MCID: EPD014
MIFTS: 31

Epididymis Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Epididymis Adenocarcinoma

MalaCards integrated aliases for Epididymis Adenocarcinoma:

Name: Epididymis Adenocarcinoma 12 15
Adenocarcinoma of the Epididymis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10368
NCIt 50 C39957
UMLS 70 C1510784

Summaries for Epididymis Adenocarcinoma

Disease Ontology : 12 An epididymis cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Epididymis Adenocarcinoma, also known as adenocarcinoma of the epididymis, is related to hydrocele and appendix adenocarcinoma. An important gene associated with Epididymis Adenocarcinoma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. Affiliated tissues include breast, ovary and testis, and related phenotypes are cellular and cardiovascular system

Related Diseases for Epididymis Adenocarcinoma

Diseases related to Epididymis Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
# Related Disease Score Top Affiliating Genes
1 hydrocele 30.3 KRT7 CALB2 AFP
2 appendix adenocarcinoma 30.3 KRT7 CDX2
3 mesothelioma, malignant 30.1 WT1 THBD KRT7 CALB2
4 teratoma 29.9 KRT7 CDX2 CALB2 AFP
5 benign mesothelioma 29.8 WT1 THBD KRT7 KRT5 CALB2
6 cystadenoma 29.6 MME KRT7 KLK3 CALB2 AFP
7 renal cell carcinoma, nonpapillary 29.0 WT1 PAX8 PAX2 MME KRT7 CD86
8 adenocarcinoma 10.4
9 anus basaloid carcinoma 10.4 PTGER4 KRT7
10 papillary thymic adenocarcinoma 10.4 PTGER4 CALB2
11 peritoneal serous papillary adenocarcinoma 10.4 WT1 PTGER4
12 fallopian tube carcinosarcoma 10.4 WT1 CALB2
13 epithelial predominant wilms' tumor 10.4 WT1 KRT7
14 cervical carcinosarcoma 10.4 MME CALB2
15 pacinian tumor 10.4 MME CALB2
16 ovarian serous adenofibroma 10.4 KRT7 CALB2
17 nephrogenic adenofibroma 10.3 WT1 KRT7
18 thyroid sarcoma 10.3 THBD PAX8
19 lung sarcomatoid carcinoma 10.3 THBD CALB2
20 ovarian serous cystadenofibroma 10.3 KRT7 CALB2
21 bladder leiomyoma 10.3 KRT7 CALB2
22 cervical mucinous adenocarcinoma 10.3 MME KRT7
23 pancreatic serous cystadenocarcinoma 10.3 MME KRT7
24 adult type testicular granulosa cell tumor 10.3 CALB2 AFP
25 apocrine adenocarcinoma 10.3 KRT7 KRT5
26 mixed epithelial stromal tumour 10.3 MME KRT7
27 dermoid cyst of ovary 10.3 CALB2 AFP
28 cervix endometriosis 10.3 PAX2 MME
29 sarcomatoid basal cell carcinoma 10.3 PTGER4 KRT5
30 clear cell papillary renal cell carcinoma 10.3 MME KRT7
31 ureter squamous cell carcinoma 10.3 KRT7 KRT5
32 spermatocele 10.3 CALB2 AFP
33 chromophil adenoma of the kidney 10.3 MME KRT7
34 inverted transitional papilloma 10.3 KRT7 KRT5
35 infected hydrocele 10.3 CALB2 AFP
36 thyroid angiosarcoma 10.3 THBD PAX8
37 bile duct cystadenocarcinoma 10.3 KRT7 AFP
38 ceruminoma 10.3 KRT7 KRT5
39 spindle cell thymoma 10.3 KRT5 CALB2
40 ovarian primitive germ cell tumor 10.3 KRT7 AFP
41 orbital cellulitis 10.3 MME KRT7
42 ovarian endodermal sinus tumor 10.3 KRT7 AFP
43 acute orbital inflammation 10.3 MME KRT7
44 ureterocele 10.3 PAX8 PAX2
45 malignant acrospiroma 10.3 KRT7 KRT5
46 pulmonary artery leiomyosarcoma 10.3 MME KRT7
47 cervical clear cell adenocarcinoma 10.3 PAX8 AFP
48 colonic lymphangioma 10.3 KRT7 AFP
49 auditory system benign neoplasm 10.3 KRT7 KRT5
50 ceruminous adenocarcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Epididymis Adenocarcinoma:



Diseases related to Epididymis Adenocarcinoma

Symptoms & Phenotypes for Epididymis Adenocarcinoma

MGI Mouse Phenotypes related to Epididymis Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CD86 CDX2 FUT4 KRT7 MME PAX2
2 cardiovascular system MP:0005385 10.07 CDX2 FUT4 KLK3 MME PAX2 PAX8
3 homeostasis/metabolism MP:0005376 9.93 AFP CD86 CDX2 FUT4 KRT7 MME
4 endocrine/exocrine gland MP:0005379 9.86 AFP CD86 CDX2 PAX2 PAX8 PTPRC
5 normal MP:0002873 9.56 CALB2 CDX2 KLK3 PAX8 PTGER4 PTPRC
6 renal/urinary system MP:0005367 9.17 FUT4 KRT7 PAX2 PAX8 PTPRC THBD

Drugs & Therapeutics for Epididymis Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Epididymis Adenocarcinoma

Genetic Tests for Epididymis Adenocarcinoma

Anatomical Context for Epididymis Adenocarcinoma

MalaCards organs/tissues related to Epididymis Adenocarcinoma:

40
Breast, Ovary, Testis, Thymus, Kidney, Liver, Lung

Publications for Epididymis Adenocarcinoma

Articles related to Epididymis Adenocarcinoma:

(show all 15)
# Title Authors PMID Year
1
Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution. 61
32619438 2020
2
Metastatic Adenocarcinoma of the Epididymis: A Case Report and Brief Literature Review. 61
29066074 2018
3
A CASE OF ADENOCARCINOMA OF THE EPIDIDYMIS WITH HYDROCELE. 61
28740052 2016
4
Primary mucinous adenocarcinoma of the epididymis: report of a rare case with molecular genetic characterization including mutation analysis of the TP53 gene. 61
25839701 2015
5
Primary adenocarcinoma of the epididymis: the therapeutic role of retroperitoneal lymphadenectomy. 61
22382506 2012
6
Radiotherapy in the treatment of epididymal adenocarcinoma - case report. 61
22310345 2012
7
Metastatic adenocarcinoma of the epididymis from pancreatic cancer successfully treated by chemotherapy and high-intensity focused ultrasound therapy: a case report and review of the literature. 61
21926538 2011
8
Primary adenocarcinoma of the epididymis: case report. 61
15338681 2004
9
[A case of primary adenocarcinoma of the epididymis]. 61
12894733 2003
10
The natural progression of adenocarcinoma of the epididymis. 61
11458082 2001
11
Primary adenocarcinoma of the epididymis: case report and review of the literature. 61
9801128 1998
12
Adenocarcinoma of the epididymis: a report of four cases and review of the literature. 61
9414191 1997
13
Papillary adenocarcinoma of the epididymis. 61
8372688 1993
14
[A case of primary adenocarcinoma of the epididymis]. 61
4676625 1972
15
Primary adenocarcinoma of the epididymis: a case of embryonal teratoma, with autopsy findings. 61
13212945 1954

Variations for Epididymis Adenocarcinoma

Expression for Epididymis Adenocarcinoma

Search GEO for disease gene expression data for Epididymis Adenocarcinoma.

Pathways for Epididymis Adenocarcinoma

GO Terms for Epididymis Adenocarcinoma

Cellular components related to Epididymis Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 THBD PTPRC MME FUT4 CD86

Biological processes related to Epididymis Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 WT1 TCF4 PAX8 PAX2 CDX2 CD86
2 kidney development GO:0001822 9.79 WT1 PAX8 MME
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 PAX8 PAX2
4 branching involved in ureteric bud morphogenesis GO:0001658 9.61 WT1 PAX8 PAX2
5 urogenital system development GO:0001655 9.6 PAX8 PAX2
6 mesonephros development GO:0001823 9.59 PAX8 PAX2
7 mesenchymal to epithelial transition GO:0060231 9.58 WT1 PAX2
8 metanephric mesenchyme development GO:0072075 9.58 WT1 PAX2
9 cellular response to gonadotropin stimulus GO:0071371 9.57 WT1 PAX8
10 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.56 PAX8 PAX2
11 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX8 PAX2
12 pronephros development GO:0048793 9.54 PAX8 PAX2
13 metanephric S-shaped body morphogenesis GO:0072284 9.52 WT1 PAX8
14 metanephric nephron tubule formation GO:0072289 9.49 PAX8 PAX2
15 metanephric distal convoluted tubule development GO:0072221 9.48 PAX8 PAX2
16 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX8 PAX2
17 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
19 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
20 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.26 PAX8 PAX2
21 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
22 pronephric field specification GO:0039003 8.96 PAX8 PAX2
23 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Molecular functions related to Epididymis Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.02 WT1 TCF4 PAX8 PAX2 CDX2

Sources for Epididymis Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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