MCID: EPD017
MIFTS: 29

Epididymis Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Epididymis Cancer

MalaCards integrated aliases for Epididymis Cancer:

Name: Epididymis Cancer 12 15
Malignant Tumor of Epididymis 12 71
Malignant Neoplasm of Epididymis 12
Malignant Epididymal Tumor 12
Neoplasm of Epididymis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10366
ICD9CM 34 187.5
NCIt 49 C3558
SNOMED-CT 67 93783009
ICD10 32 C63.0
UMLS 71 C0153602 C0346239

Summaries for Epididymis Cancer

MalaCards based summary : Epididymis Cancer, also known as malignant tumor of epididymis, is related to epididymis adenocarcinoma and papillary thymic adenocarcinoma. An important gene associated with Epididymis Cancer is CALB2 (Calbindin 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include breast, liver and testis, and related phenotypes are cellular and liver/biliary system

Related Diseases for Epididymis Cancer

Diseases related to Epididymis Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 epididymis adenocarcinoma 26.8 WT1 THBD TCF4 PTPRC PTGER4 PAX8
2 papillary thymic adenocarcinoma 10.5 PTGER4 CALB2
3 bartholin's gland adenocarcinoma 10.5 PTGER4 KRT7
4 anus basaloid carcinoma 10.5 PTGER4 KRT7
5 mediastinum sarcoma 10.5 KRT7 CALB2
6 mucinous ovarian cystadenoma 10.5 KRT7 CALB2
7 malignant syringoma 10.5 PTGER4 KRT7
8 fallopian tube carcinosarcoma 10.5 WT1 CALB2
9 ovarian serous adenofibroma 10.5 KRT7 CALB2
10 mucinous stomach adenocarcinoma 10.4 KRT7 CALB2
11 urethra adenocarcinoma 10.4 PAX8 PAX2
12 peritoneal serous papillary adenocarcinoma 10.4 WT1 PTGER4
13 ovarian serous cystadenofibroma 10.4 KRT7 CALB2
14 nephrogenic adenofibroma 10.4 WT1 KRT7
15 malignant leydig cell tumor 10.4 CALB2 AFP
16 malignant sertoli cell tumor 10.4 CALB2 AFP
17 adult type testicular granulosa cell tumor 10.4 CALB2 AFP
18 dermoid cyst of ovary 10.4 CALB2 AFP
19 intrahepatic bile duct adenoma 10.4 KRT7 AFP
20 hematocele of tunica vaginalis testis 10.4 CALB2 AFP
21 scrotum neoplasm 10.4 CALB2 AFP
22 ureterocele 10.4 PAX8 PAX2
23 bile duct cystadenocarcinoma 10.4 KRT7 AFP
24 ovarian mucinous neoplasm 10.4 PAX8 KRT7
25 colonic lymphangioma 10.4 KRT7 AFP
26 pacinian tumor 10.4 MME CALB2
27 ovarian primitive germ cell tumor 10.4 KRT7 AFP
28 ovarian endodermal sinus tumor 10.4 KRT7 AFP
29 infected hydrocele 10.4 CALB2 AFP
30 horseshoe kidney 10.4 KRT7 CALB2
31 fallopian tube adenocarcinoma 10.3 MME CALB2
32 cervix endometriosis 10.3 PAX2 MME
33 pulmonary sclerosing hemangioma 10.3 KRT7 CALB2
34 liver sarcoma 10.3 KRT7 AFP
35 mixed epithelial stromal tumour 10.3 MME KRT7
36 apocrine adenocarcinoma 10.3 KRT7 KRT5
37 monophasic synovial sarcoma 10.3 KRT7 CALB2
38 cervical adenoma malignum 10.3 MME KRT7
39 lung leiomyosarcoma 10.3 KRT5 CALB2
40 ovarian small cell carcinoma 10.3 WT1 CALB2
41 clear cell papillary renal cell carcinoma 10.3 MME KRT7
42 sarcomatoid basal cell carcinoma 10.3 PTGER4 KRT5
43 chromophil adenoma of the kidney 10.3 MME KRT7
44 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 CALB2
45 sarcomatous intrahepatic cholangiocarcinoma 10.3 KRT7 AFP
46 inverted transitional papilloma 10.3 KRT7 KRT5
47 malignant spiradenoma 10.3 KRT7 KRT5
48 ceruminoma 10.3 KRT7 KRT5
49 breast hemangiopericytoma 10.3 PTPRC KRT7
50 ureter adenocarcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Epididymis Cancer:



Diseases related to Epididymis Cancer

Symptoms & Phenotypes for Epididymis Cancer

MGI Mouse Phenotypes related to Epididymis Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 FUT4 KRT7 MME PAX2 PAX8 PTGER4
2 liver/biliary system MP:0005370 9.43 AFP MME PTGER4 PTPRC THBD WT1
3 renal/urinary system MP:0005367 9.1 KRT7 PAX2 PAX8 PTPRC THBD WT1

Drugs & Therapeutics for Epididymis Cancer

Search Clinical Trials , NIH Clinical Center for Epididymis Cancer

Genetic Tests for Epididymis Cancer

Anatomical Context for Epididymis Cancer

MalaCards organs/tissues related to Epididymis Cancer:

40
Breast, Liver, Testis, Cervix, Thymus, Kidney, Ovary

Publications for Epididymis Cancer

Articles related to Epididymis Cancer:

# Title Authors PMID Year
1
CYSTS OF THE EPIDIDYMIS, CANCER OF THE CERVIX, GRANULAR CELL MYOBLASTOMA, AND OTHER LESIONS AFTER ESTROGEN INJECTION IN NEWBORN MICE. 61
14046632 1963

Variations for Epididymis Cancer

Expression for Epididymis Cancer

Search GEO for disease gene expression data for Epididymis Cancer.

Pathways for Epididymis Cancer

Pathways related to Epididymis Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 WT1 PAX2 AFP
2 11 WT1 PAX2 MME
3 10.67 THBD PTPRC MME
4 10.36 PAX8 PAX2

GO Terms for Epididymis Cancer

Biological processes related to Epididymis Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.77 WT1 PAX8 MME
2 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 PAX8 PAX2
3 branching involved in ureteric bud morphogenesis GO:0001658 9.61 WT1 PAX8 PAX2
4 urogenital system development GO:0001655 9.6 PAX8 PAX2
5 mesonephros development GO:0001823 9.58 PAX8 PAX2
6 mesenchymal to epithelial transition GO:0060231 9.58 WT1 PAX2
7 metanephric mesenchyme development GO:0072075 9.57 WT1 PAX2
8 cellular response to gonadotropin stimulus GO:0071371 9.56 WT1 PAX8
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.55 PAX8 PAX2
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.54 PAX8 PAX2
11 pronephros development GO:0048793 9.52 PAX8 PAX2
12 metanephric S-shaped body morphogenesis GO:0072284 9.51 WT1 PAX8
13 metanephric nephron tubule formation GO:0072289 9.49 PAX8 PAX2
14 metanephric distal convoluted tubule development GO:0072221 9.48 PAX8 PAX2
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX8 PAX2
16 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX8 PAX2
17 positive regulation of metanephric DCT cell differentiation GO:2000594 9.37 PAX8 PAX2
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX8 PAX2
19 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.26 PAX8 PAX2
20 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
21 pronephric field specification GO:0039003 8.96 PAX8 PAX2
22 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Sources for Epididymis Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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