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MCID: EPD017
MIFTS: 30

Epididymis Cancer

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Epididymis Cancer

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MalaCards integrated aliases for Epididymis Cancer:

Name: Epididymis Cancer 12 15
Malignant Tumor of Epididymis 12 70
Malignant Neoplasm of Epididymis 12
Malignant Epididymal Tumor 12
Neoplasm of Epididymis 70

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10366
ICD9CM 34 187.5
NCIt 50 C3558
SNOMED-CT 67 363452003
ICD10 32 C63.0
UMLS 70 C0153602 C0346239
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Summaries for Epididymis Cancer

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MalaCards based summary : Epididymis Cancer, also known as malignant tumor of epididymis, is related to epididymis adenocarcinoma and anus basaloid carcinoma. An important gene associated with Epididymis Cancer is CALB2 (Calbindin 2), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. Affiliated tissues include breast, ovary and thymus, and related phenotypes are cellular and cardiovascular system

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Related Diseases for Epididymis Cancer

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Diseases related to Epididymis Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 epididymis adenocarcinoma 27.6 WT1 THBD TCF4 PTPRC PTGER4 PAX8
2 anus basaloid carcinoma 10.4 PTGER4 KRT7
3 papillary thymic adenocarcinoma 10.4 PTGER4 CALB2
4 peritoneal serous papillary adenocarcinoma 10.4 WT1 PTGER4
5 fallopian tube carcinosarcoma 10.4 WT1 CALB2
6 epithelial predominant wilms' tumor 10.4 WT1 KRT7
7 adult type testicular granulosa cell tumor 10.4 CALB2 AFP
8 ovarian serous adenofibroma 10.4 KRT7 CALB2
9 nephrogenic adenofibroma 10.3 WT1 KRT7
10 thyroid sarcoma 10.3 THBD PAX8
11 lung sarcomatoid carcinoma 10.3 THBD CALB2
12 ovarian serous cystadenofibroma 10.3 KRT7 CALB2
13 dermoid cyst of ovary 10.3 CALB2 AFP
14 bladder leiomyoma 10.3 KRT7 CALB2
15 cervical carcinosarcoma 10.3 MME CALB2
16 pacinian tumor 10.3 MME CALB2
17 spermatocele 10.3 CALB2 AFP
18 infected hydrocele 10.3 CALB2 AFP
19 bile duct cystadenocarcinoma 10.3 KRT7 AFP
20 ovarian primitive germ cell tumor 10.3 KRT7 AFP
21 ovarian endodermal sinus tumor 10.3 KRT7 AFP
22 cervical mucinous adenocarcinoma 10.3 MME KRT7
23 cervical clear cell adenocarcinoma 10.3 PAX8 AFP
24 pancreatic serous cystadenocarcinoma 10.3 MME KRT7
25 colonic lymphangioma 10.3 KRT7 AFP
26 thyroid angiosarcoma 10.3 THBD PAX8
27 mixed epithelial stromal tumour 10.3 MME KRT7
28 ureterocele 10.3 PAX8 PAX2
29 cervix endometriosis 10.3 PAX2 MME
30 apocrine adenocarcinoma 10.3 KRT7 KRT5
31 clear cell papillary renal cell carcinoma 10.3 MME KRT7
32 liver sarcoma 10.3 KRT7 AFP
33 chromophil adenoma of the kidney 10.3 MME KRT7
34 sarcomatoid basal cell carcinoma 10.3 PTGER4 KRT5
35 orbital cellulitis 10.3 MME KRT7
36 ureter squamous cell carcinoma 10.3 KRT7 KRT5
37 acute orbital inflammation 10.3 MME KRT7
38 pulmonary artery leiomyosarcoma 10.3 MME KRT7
39 biliary tract benign neoplasm 10.3 KRT7 AFP
40 inverted transitional papilloma 10.3 KRT7 KRT5
41 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.3 PTPRC FUT4
42 ceruminoma 10.3 KRT7 KRT5
43 spindle cell thymoma 10.3 KRT5 CALB2
44 sarcomatous intrahepatic cholangiocarcinoma 10.3 KRT7 AFP
45 cervical serous adenocarcinoma 10.3 WT1 MME
46 malignant acrospiroma 10.3 KRT7 KRT5
47 auditory system benign neoplasm 10.3 KRT7 KRT5
48 ceruminous adenocarcinoma 10.3 KRT7 KRT5
49 gray zone lymphoma 10.3 MME FUT4
50 cutaneous mucoepidermoid carcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Epididymis Cancer:



Diseases related to Epididymis Cancer
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Symptoms & Phenotypes for Epididymis Cancer

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MGI Mouse Phenotypes related to Epididymis Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CD86 CDX2 FUT4 KRT7 MME PAX2
2 cardiovascular system MP:0005385 10.07 CDX2 FUT4 KLK3 MME PAX2 PAX8
3 homeostasis/metabolism MP:0005376 9.93 AFP CD86 CDX2 FUT4 KRT7 MME
4 endocrine/exocrine gland MP:0005379 9.86 AFP CD86 CDX2 PAX2 PAX8 PTPRC
5 normal MP:0002873 9.56 CALB2 CDX2 KLK3 PAX8 PTGER4 PTPRC
6 renal/urinary system MP:0005367 9.17 FUT4 KRT7 PAX2 PAX8 PTPRC THBD
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Drugs & Therapeutics for Epididymis Cancer

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Search Clinical Trials , NIH Clinical Center for Epididymis Cancer

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Genetic Tests for Epididymis Cancer

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Anatomical Context for Epididymis Cancer

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MalaCards organs/tissues related to Epididymis Cancer:

40
Breast, Ovary, Thymus, Kidney, Liver, Cervix, Lung
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Publications for Epididymis Cancer

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Articles related to Epididymis Cancer:

# Title Authors PMID Year
1
CYSTS OF THE EPIDIDYMIS, CANCER OF THE CERVIX, GRANULAR CELL MYOBLASTOMA, AND OTHER LESIONS AFTER ESTROGEN INJECTION IN NEWBORN MICE. 61
14046632 1963
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Variations for Epididymis Cancer

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Expression for Epididymis Cancer

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Search GEO for disease gene expression data for Epididymis Cancer.
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Pathways for Epididymis Cancer

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Pathways related to Epididymis Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.61 PTPRC MME CD86
2
Wnt / Hedgehog / Notch 4
11.52 PAX2 FUT4 CDX2 AFP
3
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.3 WT1 PAX2 MME
4
Dendritic Cells Developmental Lineage Pathway 64
11.2 THBD PTPRC MME
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.05 WT1 PAX2 CDX2 AFP
6
ID signaling pathway 1
10.53 PAX8 PAX2
Sources

GO Terms for Epididymis Cancer

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Cellular components related to Epididymis Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 THBD PTPRC MME FUT4 CD86

Biological processes related to Epididymis Cancer according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 WT1 TCF4 PAX8 PAX2 CDX2 CD86
2 kidney development GO:0001822 9.79 WT1 PAX8 MME
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 PAX8 PAX2
4 branching involved in ureteric bud morphogenesis GO:0001658 9.61 WT1 PAX8 PAX2
5 urogenital system development GO:0001655 9.6 PAX8 PAX2
6 mesonephros development GO:0001823 9.59 PAX8 PAX2
7 mesenchymal to epithelial transition GO:0060231 9.58 WT1 PAX2
8 metanephric mesenchyme development GO:0072075 9.58 WT1 PAX2
9 cellular response to gonadotropin stimulus GO:0071371 9.57 WT1 PAX8
10 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.56 PAX8 PAX2
11 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX8 PAX2
12 pronephros development GO:0048793 9.54 PAX8 PAX2
13 metanephric S-shaped body morphogenesis GO:0072284 9.52 WT1 PAX8
14 metanephric nephron tubule formation GO:0072289 9.49 PAX8 PAX2
15 metanephric distal convoluted tubule development GO:0072221 9.48 PAX8 PAX2
16 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX8 PAX2
17 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
19 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
20 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.26 PAX8 PAX2
21 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
22 pronephric field specification GO:0039003 8.96 PAX8 PAX2
23 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Molecular functions related to Epididymis Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.02 WT1 TCF4 PAX8 PAX2 CDX2
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Sources for Epididymis Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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