MCID: EPD088
MIFTS: 26

Epididymis Disease

Categories: Reproductive diseases

Aliases & Classifications for Epididymis Disease

MalaCards integrated aliases for Epididymis Disease:

Name: Epididymis Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080373

Summaries for Epididymis Disease

Disease Ontology : 12 A male reproductive system disease that is located in the epididymis.

MalaCards based summary : Epididymis Disease is related to prostatic cyst and pineal region meningioma. An important gene associated with Epididymis Disease is DEFB130A (Defensin Beta 130A), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include epididymis, bone and skin.

Related Diseases for Epididymis Disease

Diseases related to Epididymis Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 572)
# Related Disease Score Top Affiliating Genes
1 prostatic cyst 10.4 KLK3 EPPIN
2 pineal region meningioma 10.4 CRP AFP
3 hematocele of tunica vaginalis testis 10.4 CRP AFP
4 liver inflammatory pseudotumor 10.4 CRP AFP
5 testicular infarct 10.4 CRP AFP
6 glossopharyngeal nerve paralysis 10.4 KLK3 CRP AFP
7 infected hydrocele 10.3 CRP AFP
8 cold agglutinin disease 10.3 IL6 CRP
9 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
10 systemic autoimmune disease 10.3 IL6 CRP
11 cryopyrin-associated periodic syndrome 10.3 IL6 CRP
12 anterior scleritis 10.3 TNF CRP
13 pyuria 10.3 KLK3 IL6 CRP
14 posterior scleritis 10.2 TNF CRP
15 skeletal tuberculosis 10.2 TNF CRP
16 external pathological resorption 10.2 TNF IL6
17 scorpion envenomation 10.2 TNF IL6
18 epididymo-orchitis 10.2 KLK3 CRP CRISP1 AFP
19 hemorrhoid 10.2 TNF KLK3 CRP
20 pericoronitis 10.2 IL1B CRP
21 anal fistula 10.2 TNF CRP AFP
22 idiopathic anterior uveitis 10.2 TNF IL6
23 proctitis 10.2 TNF KLK3 CRP
24 streptococcal toxic-shock syndrome 10.2 TNF IL6
25 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 TNF IL6
26 panophthalmitis 10.2 CRP CD4
27 basidiobolomycosis 10.2 IL10 CRP AFP
28 critical illness polyneuropathy 10.2 TNF CRP
29 cardiogenic shock 10.2 TNF IL6
30 louse-borne relapsing fever 10.2 TNF CRP
31 punctate inner choroidopathy 10.1 TNF IL10
32 epidural abscess 10.1 CRP CD4
33 acute transverse myelitis 10.1 IL6 IL10
34 tropical endomyocardial fibrosis 10.1 TNF IL10
35 periodontitis, chronic 10.1 IL6 IL1B
36 coronary aneurysm 10.1 TNF IL6 CRP
37 chondromalacia 10.1 TNF IL6 CRP
38 heart aneurysm 10.1 TNF IL6 CRP
39 null-cell leukemia 10.1 TNF IL6
40 primary syphilis 10.1 CRP CD4
41 urogenital tuberculosis 10.1 CRP CD4
42 melancholia 10.1 TNF IL6 CRP
43 acute gonococcal cervicitis 10.1 IL6 IL10
44 compartment syndrome 10.1 TNF IL6 CRP
45 breast abscess 10.1 CRP CD4
46 hypersensitivity vasculitis 10.1 TNF IL6 CRP
47 aspiration pneumonia 10.1 TNF IL6 CRP
48 tuberculous epididymitis 10.1 TNF KLK3 CRP AFP
49 indolent plasma cell myeloma 10.1 IL6 IL1B
50 multifocal choroiditis 10.1 TNF IL10

Graphical network of the top 20 diseases related to Epididymis Disease:



Diseases related to Epididymis Disease

Symptoms & Phenotypes for Epididymis Disease

Drugs & Therapeutics for Epididymis Disease

Search Clinical Trials , NIH Clinical Center for Epididymis Disease

Genetic Tests for Epididymis Disease

Anatomical Context for Epididymis Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Epididymis Disease:

19
Epididymis

MalaCards organs/tissues related to Epididymis Disease:

40
Bone, Skin, Heart, Liver, Lung, Eye, Lymph Node

Publications for Epididymis Disease

Variations for Epididymis Disease

Expression for Epididymis Disease

Search GEO for disease gene expression data for Epididymis Disease.

Pathways for Epididymis Disease

Pathways related to Epididymis Disease according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 TNF SEMG1 IL6 IL1B IL10 EPPIN
2
Show member pathways
12.79 TNF IL6 IL1B IL10 CD4
3
Show member pathways
12.54 TNF IL6 IL1B IL10 CD4
4
Show member pathways
12.53 TNF IL6 IL1B IL10 CD4
5
Show member pathways
12.51 TNF IL6 IL1B IL10 CD4
6
Show member pathways
12.29 TNF IL6 IL1B CRP
7 12.18 TNF IL6 IL1B IL10
8
Show member pathways
12.16 TNF IL6 IL1B IL10
9 12.12 TNF IL6 IL1B IL10
10
Show member pathways
12.07 SEMG1 EPPIN DEFB130A DEFB124 DEFB121 CD4
11 11.94 TNF IL6 IL1B IL10 CD4
12 11.92 TNF IL6 IL10 CD4
13 11.91 TNF IL6 IL1B IL10
14 11.85 TNF IL6 IL1B IL10
15 11.82 TNF IL6 IL1B CD4
16 11.7 TNF IL1B IL10 CD4
17 11.66 TNF IL6 IL1B IL10
18 11.64 TNF IL6 IL10
19
Show member pathways
11.62 TNF IL6 IL1B
20 11.61 TNF IL6 IL1B
21 11.56 TNF IL6 IL1B
22 11.47 TNF KLK3 IL1B
23 11.46 TNF IL6 IL1B IL10
24 11.43 TNF IL6 IL1B
25
Show member pathways
11.43 TNF IL6 IL1B IL10 CD4
26 11.42 TNF IL6 IL1B IL10
27 11.26 TNF IL6 IL1B
28 11.24 TNF IL6 IL1B IL10
29 11.23 TNF IL6 IL1B
30 11.22 TNF IL6 IL1B IL10 CD4
31 11.17 TNF IL6 IL1B IL10
32 10.97 TNF IL6 CRP
33 10.74 IL6 IL1B
34 10.48 TNF IL6 IL1B IL10 CD4

GO Terms for Epididymis Disease

Cellular components related to Epididymis Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 WFDC13 WFDC11 TNF SEMG1 KLK3 IL6
2 extracellular region GO:0005576 9.55 WFDC13 WFDC11 TNF SPAG11B SEMG1 KLK3

Biological processes related to Epididymis Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.03 TNF IL6 IL1B IL10 CD4
2 cellular protein metabolic process GO:0044267 9.92 SEMG1 KLK3 IL6 AFP
3 cytokine-mediated signaling pathway GO:0019221 9.91 TNF IL6 IL1B IL10 CD4
4 cellular response to lipopolysaccharide GO:0071222 9.86 TNF IL6 IL1B IL10
5 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IL1B
6 response to glucocorticoid GO:0051384 9.78 TNF IL6 IL10
7 positive regulation of T cell proliferation GO:0042102 9.77 IL6 IL1B CD4
8 positive regulation of interleukin-8 production GO:0032757 9.76 TNF IL6 IL1B
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.76 TNF IL6 IL1B IL10
10 antibacterial humoral response GO:0019731 9.74 WFDC13 WFDC11 SEMG1
11 positive regulation of JAK-STAT cascade GO:0046427 9.65 TNF IL6 IL10
12 defense response GO:0006952 9.65 TNF SPAG11B DEFB130A DEFB124 DEFB121
13 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
14 negative regulation of calcium ion import GO:0090281 9.61 SEMG1 EPPIN
15 negative regulation of neurogenesis GO:0050768 9.61 TNF IL6 IL1B
16 endothelial cell apoptotic process GO:0072577 9.6 TNF IL10
17 negative regulation of cytokine production involved in immune response GO:0002719 9.58 TNF IL10
18 positive regulation of glial cell proliferation GO:0060252 9.58 TNF IL6 IL1B
19 negative regulation of flagellated sperm motility GO:1901318 9.55 SEMG1 EPPIN
20 positive regulation of fever generation GO:0031622 9.54 TNF IL1B
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 TNF IL1B IL10
22 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
23 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IL1B
25 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
26 defense response to bacterium GO:0042742 9.17 TNF SPAG11B IL10 EPPIN DEFB130A DEFB124
27 vascular endothelial growth factor production GO:0010573 9.13 TNF IL6 IL1B

Molecular functions related to Epididymis Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL6 IL1B IL10

Sources for Epididymis Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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