MCID: EPD046
MIFTS: 36

Epididymitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymitis

MalaCards integrated aliases for Epididymitis:

Name: Epididymitis 12 76 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9402
ICD10 33 N45.1
MeSH 44 D004823
UMLS 73 C0014534

Summaries for Epididymitis

MalaCards based summary : Epididymitis is related to tuberculous epididymitis and epididymo-orchitis. An important gene associated with Epididymitis is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways is Metabolism of proteins. The drugs Sulfamethoxazole and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include prostate, testis and spinal cord.

Wikipedia : 76 Epididymitis is a medical condition characterized by inflammation of the epididymis, a curved structure... more...

Related Diseases for Epididymitis

Diseases related to Epididymitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 tuberculous epididymitis 34.3 CGB3 KLK3
2 epididymo-orchitis 30.3 CCT5 CRP INHBB PDCD11 TNP1
3 chlamydia 29.8 CD40LG CRP
4 pelvic inflammatory disease 29.5 CD40LG CRP
5 dirofilariasis 29.3 CD40LG CRP
6 brucellosis 29.1 CD40LG CRP
7 purpura 28.9 CD40LG CRP
8 epididymis cancer 11.1
9 epididymis adenomatoid tumor 10.9
10 renal cysts and diabetes syndrome 10.9
11 filarial elephantiasis 10.9
12 diethylstilbestrol syndrome 10.9
13 endodermal sinus tumor 10.7 CGB3 KLK3
14 acute cystitis 10.5 CRP KLK3
15 proctitis 10.5 CRP KLK3
16 bladder disease 10.5 CRP KLK3
17 relapsing fever 10.4 ARSI CRP
18 louse-borne relapsing fever 10.4 ARSI CRP
19 male reproductive system disease 10.3 KLK3 TNP1
20 orchitis 10.3
21 azoospermia 10.2
22 prostatitis 10.2
23 testicular torsion 10.1
24 infertility 10.1
25 hydrocele 10.1
26 urethritis 10.1
27 testicular infarct 10.0
28 acalculous cholecystitis 10.0 CD40LG CRP
29 mononeuritis multiplex 10.0 CD40LG CRP
30 acute maxillary sinusitis 10.0 CD40LG CRP
31 japanese spotted fever 10.0 CD40LG CRP
32 suppurative otitis media 10.0 CD40LG CRP
33 urethral syndrome 10.0 CD40LG KLK3
34 adenomatoid tumor 10.0
35 dressler's syndrome 10.0 CD40LG CRP
36 hypersensitivity vasculitis 10.0 CD40LG CRP
37 central nervous system vasculitis 10.0 CD40LG CRP
38 intussusception 10.0 CD40LG CRP
39 hypersensitivity reaction type iii disease 10.0 CD40LG CRP
40 pyelitis 10.0 CD40LG CRP
41 aging 10.0
42 mumps 10.0
43 streptococcal meningitis 10.0 CD40LG CRP
44 endocardium disease 10.0 CD40LG CRP
45 scrub typhus 10.0 CD40LG CRP
46 granulomatous hepatitis 9.9 CD40LG CRP
47 multiple cranial nerve palsy 9.9 CD40LG CRP
48 hemorrhagic fever with renal syndrome 9.9 CD40LG CRP
49 spermatocele 9.9
50 lymph node disease 9.9 CD40LG CRP

Graphical network of the top 20 diseases related to Epididymitis:



Diseases related to Epididymitis

Symptoms & Phenotypes for Epididymitis

Drugs & Therapeutics for Epididymitis

Drugs for Epididymitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Fosfomycin Approved Phase 4 23155-02-4 446987
6
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8 Anti-Bacterial Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3
10 Clavulanic Acid Phase 4
11 Renal Agents Phase 4
12 Folic Acid Antagonists Phase 4
13 Amdinocillin Pivoxil Phase 4
14 Amoxicillin-Potassium Clavulanate Combination Phase 4
15 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
16 Cytochrome P-450 Enzyme Inhibitors Phase 4
17 Topoisomerase Inhibitors Phase 4
18 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
19 Vitamin B Complex Phase 4
20 Antibiotics, Antitubercular Phase 4
21 Antiparasitic Agents Phase 4
22 Antiprotozoal Agents Phase 4
23 Antimalarials Phase 4
24 beta-Lactamase Inhibitors Phase 4
25 Folate Nutraceutical Phase 4
26 Vitamin B9 Nutraceutical Phase 4
27
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
28 Hypolipidemic Agents Phase 3
29 Lipid Regulating Agents Phase 3
30 Antitubercular Agents Phase 3
31 Antimetabolites Phase 3
32
Acetylcholine Approved Phase 2,Phase 1 51-84-3 187
33 abobotulinumtoxinA Phase 2,Phase 1
34 Cholinergic Agents Phase 2,Phase 1
35 Neuromuscular Agents Phase 2,Phase 1
36 Neurotransmitter Agents Phase 2,Phase 1
37 onabotulinumtoxinA Phase 2,Phase 1
38 Peripheral Nervous System Agents Phase 2,Phase 1
39 Botulinum Toxins, Type A Phase 2,Phase 1
40 Botulinum Toxins Phase 2,Phase 1
41
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
42
Acetaminophen Approved Not Applicable 103-90-2 1983

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy. Not yet recruiting NCT03228108 Phase 4 Ciprofloxacin;Trimethoprim/Sulfamethoxazole;Fosfomycin;Pivmecillinam/augmentin
2 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
3 Randomized Control Trial of the Use of Botox to Treat Chronic Scrotal Pain Enrolling by invitation NCT02249234 Phase 2 Botox;Placebo
4 Use of Botox to Treat Scrotal Pain Completed NCT01832194 Phase 1 Botox
5 Randomized Population-Based Study on Chlamydia Trachomatis Screening Completed NCT00827970 Not Applicable
6 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
7 Does Local Cooling of Testis in Patients With Epididymitis Relieve Pain and Reduce Quantity of Analgetics Intake? Recruiting NCT02943772 Not Applicable
8 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Recruiting NCT03477149 Not Applicable
9 Feasibility of Prostatic Arterial Embolization in Low-risk Patients With Unilateral Prostate Cancer Under Active Surveillance: Monocentric Pilot Study Not yet recruiting NCT03407963 Not Applicable

Search NIH Clinical Center for Epididymitis

Cochrane evidence based reviews: epididymitis

Genetic Tests for Epididymitis

Anatomical Context for Epididymitis

MalaCards organs/tissues related to Epididymitis:

41
Prostate, Testis, Spinal Cord, Testes, Appendix, Endothelial, Thyroid

Publications for Epididymitis

Articles related to Epididymitis:

(show top 50) (show all 798)
# Title Authors Year
1
The utility of scrotal ultrasonography in the emergent setting: beyond epididymitis versus torsion. ( 29679169 )
2018
2
Acute epididymitis. ( 29470373 )
2018
3
Epididymal ultrastructural changes associated with chronic cholestasis after bile duct ligation in adult rats. ( 29952690 )
2018
4
Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility. ( 29516876 )
2018
5
Different managements for prepubertal epididymitis based on a preexisting genitourinary anomaly diagnosis. ( 29668706 )
2018
6
Case of an Airsoft pellet induced epididymal laceration and secondary testicular torsion with the loss of affected testis. ( 29034179 )
2018
7
Alveolar paratesticular rhabdomyosarcoma mimicing epididymitis: Case report and literature review. ( 29924027 )
2018
8
Cytological diagnosis of a testicular tumour in an infertile male which mimicked epididymitis. ( 29863791 )
2018
9
Epididymitis ( 28613565 )
2018
10
Lipopolysaccharide and lipotheicoic acid differentially modulate epididymal cytokine and chemokine profiles and sperm parameters in experimental acute epididymitis. ( 29311626 )
2018
11
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
12
Recurrent bilateral Mycobacterium bovis necrotizing epididymitis: a case report. ( 29776430 )
2018
13
Optic disc granuloma with epididymitis: a diagnostic challenge. ( 28534271 )
2017
14
Tuberculosis epididymitis complicated by a cutaneous fistula. ( 29127136 )
2017
15
Symplastic epididymal leiomyoma with bizarre cytology. ( 28868647 )
2017
16
Epididymal Cystic Lymphangioma Presenting as Scrotal Swelling in a Post Surgery Case of Carcinoma Rectum- A Case Report. ( 29207807 )
2017
17
Epididymal metastasis from prostate adenocarcinoma: An unusual and challenging diagnosis suspected in gallium-68 prostate-specific membrane antigen-positron emission tomography/computed tomography and histologically confirmed. ( 28216940 )
2017
18
Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. ( 28619239 )
2017
19
Case 3: Abdominal Pain and Epididymitis in an 8-year-old Boy. ( 28864736 )
2017
20
Evaluating the Necessity of Antibiotics in the Treatment of Acute Epididymitis in Pediatric Patients: A Literature Review of Retrospective Studies and Data Analysis. ( 28099292 )
2017
21
Sweet's syndrome with idiopathic epididymitis. ( 28951713 )
2017
22
Retrospective Review of Gonococcal and Chlamydial Cases of Epididymitis at 2 Canadian Sexually Transmitted Infection Clinics, 2004-2014. ( 28499286 )
2017
23
What are the differences between older and younger patients with epididymitis? ( 28480347 )
2017
24
Novel MEFV variant Q311H in an incomplete BehAset's disease patient with recurrent epididymitis. ( 26593126 )
2016
25
Epididymitis: What You Should Know. ( 27929255 )
2016
26
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
27
Rare case of epididymal dirofilariasis. ( 26976948 )
2016
28
Epididymal Metastasis of Prostate Cancer Detected With 68Ga-PSMA-PET/CT. ( 27355849 )
2016
29
Epididymal papillary cystadenocarcinoma metastasising to the testis in a patient with infertility managed with Onco-microTeSE. ( 27887012 )
2016
30
Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft-Shelled Turtle Pelodiscus sinensis During the Hibernation Season. ( 27532861 )
2016
31
Epididymitis with Epididymal Cyst Indicating Immunoglobulin A Vasculitis in an AdultAi Nanbu, Kazumitsu Sugiura, Naoto Sassa, Masashi Akiyama. ( 26911283 )
2016
32
Septic Pulmonary Emboli Associated with Klebsiella Pneumoniae Epididymitis. ( 26443643 )
2016
33
A case of testicular infarction from the complications of Klebsiella oxytoca induced acute epididymitis. ( 26643901 )
2016
34
Embryonal rhabdomyosarcoma of the epididymis presenting as epididymitis: A case report. ( 27073679 )
2016
35
Epididymal Adenomatoid Tumor: A Very Rare Paratesticular Tumor of Childhood. ( 28003830 )
2016
36
Testicular Spermatozoa Are of Better Quality Than Epididymal Spermatozoa in Patients With Obstructive Azoospermia. ( 27888149 )
2016
37
The publication "Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue" by Enrico Campioli, Tam B. Duong, FranAsois Deschamps, Vassilios Papadopoulos, Environmental Research 140 (2015), 145-156, merits some critical comments. ( 26548739 )
2016
38
Epididymitis: An Overview. ( 27929243 )
2016
39
Tuberculous Epididymitis. ( 25945724 )
2015
40
Distribution of Epididymal Involvement in Mumps Epididymo-orchitis. ( 26014328 )
2015
41
Percutaneous epididymal sperm aspiration as a method for sperm retrieval in men with obstructive azoospermia seeking fertility: operative and laboratory aspects. ( 26401878 )
2015
42
Serum human epididymal protein 4 (HE4) as biomarker for the differentiation between epithelial ovarian cancer and ovarian metastases of gastrointestinal origin. ( 25560808 )
2015
43
Early diagnosis of testicular torsion in rats by measuring plasma d-dimer levels: comparative study with epididymitis. ( 25840081 )
2015
44
Re: Adrian Pilatz, Hamid Hossain, Rolf Kaiser, et al. Acute Epididymitis Revisited: Impact of Molecular Diagnostics on Etiology and Contemporary Guideline Recommendations Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2014.12.005. ( 25864158 )
2015
45
Contagious epididymitis due to Brucella ovis: relationship between sexual function, serology and bacterial shedding in semen. ( 26025374 )
2015
46
Orchitis and Epididymitis in Koalas (Phascolarctos cinereus) Infected With Chlamydia pecorum. ( 25637084 )
2015
47
Epididymitis. ( 26602616 )
2015
48
Epididymitis: revelations at the convergence of clinical and basic sciences. ( 26112484 )
2015
49
Epididymitis: ascending infection restricted by segmental boundaries. ( 25994666 )
2015
50
Acute epididymitis: what you think is not always what you get. ( 26001613 )
2015

Variations for Epididymitis

Expression for Epididymitis

Search GEO for disease gene expression data for Epididymitis.

Pathways for Epididymitis

Pathways related to Epididymitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ARSI CCT5 CGB3 INHBB KLK3 TUBB4B

GO Terms for Epididymitis

Cellular components related to Epididymitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CD40LG CGB3 CRISP2 CRP INHBB KLK3
2 extracellular region GO:0005576 9.17 ARSI CD40LG CGB3 CRP INHBB KLK3

Sources for Epididymitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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