MCID: EPD046
MIFTS: 35

Epididymitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymitis

MalaCards integrated aliases for Epididymitis:

Name: Epididymitis 12 76 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9402
ICD10 33 N45.1
MeSH 44 D004823
SNOMED-CT 68 31070006
UMLS 73 C0014534

Summaries for Epididymitis

MalaCards based summary : Epididymitis is related to tuberculous epididymitis and epididymo-orchitis. An important gene associated with Epididymitis is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways is Metabolism of proteins. The drugs Trimethoprim and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include prostate, testis and testes.

Wikipedia : 76 Epididymitis is a medical condition characterized by inflammation of the epididymis, a curved structure... more...

Related Diseases for Epididymitis

Diseases related to Epididymitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 tuberculous epididymitis 33.6 CGB3 KLK3
2 epididymo-orchitis 30.4 CCT5 CRP INHBB PDCD11 TNP1
3 epididymis cancer 11.2
4 renal cysts and diabetes syndrome 11.1
5 filarial elephantiasis 11.1
6 epididymis adenomatoid tumor 11.1
7 diethylstilbestrol syndrome 11.1
8 orchitis 10.5
9 azoospermia 10.4
10 chlamydia 10.3
11 testicular torsion 10.3
12 hydrocele 10.2
13 infertility 10.2
14 urethritis 10.2
15 adenomatoid tumor 10.2
16 vas deferens, congenital bilateral aplasia of 10.1
17 mumps 10.1
18 endodermal sinus tumor 10.1 CGB3 KLK3
19 relapsing fever 10.1 ARSI CRP
20 cryptorchidism, unilateral or bilateral 10.1
21 prostatitis 10.1
22 rhabdomyosarcoma 10.1
23 louse-borne relapsing fever 10.0 ARSI CRP
24 acute cystitis 10.0 CRP KLK3
25 proctitis 10.0 CRP KLK3
26 von hippel-lindau syndrome 10.0
27 spermatocele 10.0
28 varicocele 10.0
29 leiomyoma 10.0
30 bladder disease 10.0 CRP KLK3
31 spinal cord injury 9.9
32 melanotic neuroectodermal tumor 9.9
33 adenocarcinoma 9.9
34 granulomatous orchitis 9.9
35 purpura 9.9
36 testicular infarct 9.9
37 vasculitis 9.9
38 urinary system disease 9.9 CRP KLK3
39 ovarian cancer 9.9
40 hemangioma 9.9
41 male infertility 9.9
42 pelvic inflammatory disease 9.9
43 dirofilariasis 9.9
44 vaginitis 9.9
45 cystadenoma 9.9
46 diverticulitis 9.9
47 meningitis 9.9
48 malakoplakia 9.9
49 posterior urethral valves 9.9
50 immunoglobulin a vasculitis 9.9

Graphical network of the top 20 diseases related to Epididymitis:



Diseases related to Epididymitis

Symptoms & Phenotypes for Epididymitis

Drugs & Therapeutics for Epididymitis

Drugs for Epididymitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3
leucovorin Approved Phase 4 58-05-9 6006 143
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6
Fosfomycin Approved Phase 4 23155-02-4 446987
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8 Anti-Bacterial Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3
10 Antiprotozoal Agents Phase 4
11 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
12 Renal Agents Phase 4
13 Antiparasitic Agents Phase 4
14 Iron-Dextran Complex Phase 4
15 Anti-Infective Agents, Urinary Phase 4
16 Antimalarials Phase 4
17 Folate Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Vitamin B9 Phase 4
20 Clavulanic Acids Phase 4
21 Vitamin B Complex Phase 4
22 Antibiotics, Antitubercular Phase 4
23 Folic Acid Antagonists Phase 4
24 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
25 Topoisomerase Inhibitors Phase 4
26 beta-Lactamase Inhibitors Phase 4
27 Amoxicillin-Potassium Clavulanate Combination Phase 4
28 Amdinocillin Pivoxil Phase 4
29
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
30 Lipid Regulating Agents Phase 3
31 Antimetabolites Phase 3
32 Hypolipidemic Agents Phase 3
33 Antitubercular Agents Phase 3
34
Acetylcholine Approved Phase 2,Phase 1 51-84-3 187
35 Acetylcholine Release Inhibitors Phase 2,Phase 1
36 Neuromuscular Agents Phase 2,Phase 1
37 onabotulinumtoxinA Phase 2,Phase 1
38 abobotulinumtoxinA Phase 2,Phase 1
39 Cholinergic Agents Phase 2,Phase 1
40 Neurotransmitter Agents Phase 2,Phase 1
41 Botulinum Toxins Phase 2,Phase 1
42 Botulinum Toxins, Type A Phase 2,Phase 1
43 Peripheral Nervous System Agents Phase 2,Phase 1
44
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
45
Acetaminophen Approved Not Applicable 103-90-2 1983

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
2 Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy. Not yet recruiting NCT03228108 Phase 4 Ciprofloxacin;Trimethoprim/Sulfamethoxazole;Fosfomycin;Pivmecillinam/augmentin
3 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
4 Randomized Control Trial of the Use of Botox to Treat Chronic Scrotal Pain Unknown status NCT02249234 Phase 2 Botox;Placebo
5 Use of Botox to Treat Scrotal Pain Completed NCT01832194 Phase 1 Botox
6 Does Local Cooling of Testis in Patients With Epididymitis Relieve Pain and Reduce Quantity of Analgetics Intake? Unknown status NCT02943772 Not Applicable
7 Randomized Population-Based Study on Chlamydia Trachomatis Screening Completed NCT00827970 Not Applicable
8 Cosmetic Appeal, HRQoL and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer Completed NCT03744494 Not Applicable
9 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
10 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Recruiting NCT03477149 Not Applicable
11 Feasibility of Prostatic Arterial Embolization in Low-risk Patients With Unilateral Prostate Cancer Under Active Surveillance: Monocentric Pilot Study Recruiting NCT03407963 Not Applicable

Search NIH Clinical Center for Epididymitis

Cochrane evidence based reviews: epididymitis

Genetic Tests for Epididymitis

Anatomical Context for Epididymitis

MalaCards organs/tissues related to Epididymitis:

41
Prostate, Testis, Testes, Spinal Cord, Appendix, Brain, Liver

Publications for Epididymitis

Articles related to Epididymitis:

(show top 50) (show all 578)
# Title Authors Year
1
The utility of scrotal ultrasonography in the emergent setting: beyond epididymitis versus torsion. ( 29679169 )
2018
2
Acute epididymitis. ( 29470373 )
2018
3
Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility. ( 29516876 )
2018
4
Different managements for prepubertal epididymitis based on a preexisting genitourinary anomaly diagnosis. ( 29668706 )
2018
5
Alveolar paratesticular rhabdomyosarcoma mimicing epididymitis: Case report and literature review. ( 29924027 )
2018
6
Cytological diagnosis of a testicular tumour in an infertile male which mimicked epididymitis. ( 29863791 )
2018
7
Epididymitis ( 28613565 )
2018
8
Lipopolysaccharide and lipotheicoic acid differentially modulate epididymal cytokine and chemokine profiles and sperm parameters in experimental acute epididymitis. ( 29311626 )
2018
9
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
10
Recurrent bilateral Mycobacterium bovis necrotizing epididymitis: a case report. ( 29776430 )
2018
11
Acute Psychosis After Treatment of Epididymitis with Ciprofloxacin. ( 30013869 )
2018
12
Alveolar paratesticular rhabdomyosarcoma mimicing epididymitis: Case report and literature review: Erratum. ( 30024569 )
2018
13
Treatment of Acute Epididymitis: A Systematic Review and Discussion of the Implications for Treatment Based on Etiology. ( 30044339 )
2018
14
Acute Hepatic Failure and Epididymitis in a Hispanic Patient With Active Systemic Lupus Erythematosus. ( 30116443 )
2018
15
Endoscopic injection of bulking agent around the ejaculatory ducts at the verumontanum for recurrent paediatric epididymitis. ( 30154047 )
2018
16
Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha. ( 30398566 )
2018
17
Brucella canis infection in a young dog with epididymitis and orchitis. ( 30516477 )
2018
18
Optic disc granuloma with epididymitis: a diagnostic challenge. ( 28534271 )
2017
19
Tuberculosis epididymitis complicated by a cutaneous fistula. ( 29127136 )
2017
20
Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. ( 28619239 )
2017
21
Case 3: Abdominal Pain and Epididymitis in an 8-year-old Boy. ( 28864736 )
2017
22
Evaluating the Necessity of Antibiotics in the Treatment of Acute Epididymitis in Pediatric Patients: A Literature Review of Retrospective Studies and Data Analysis. ( 28099292 )
2017
23
Sweet's syndrome with idiopathic epididymitis. ( 28951713 )
2017
24
Retrospective Review of Gonococcal and Chlamydial Cases of Epididymitis at 2 Canadian Sexually Transmitted Infection Clinics, 2004-2014. ( 28499286 )
2017
25
What are the differences between older and younger patients with epididymitis? ( 28480347 )
2017
26
Novel algorithm for management of acute epididymitis. ( 27714879 )
2017
27
Editorial Comment to Novel algorithm for management of acute epididymitis. ( 27859660 )
2017
28
Testicular infarction in a patient with spinal cord injury with epididymitis: A case report. ( 27904914 )
2017
29
Novel MEFV variant Q311H in an incomplete BehAset's disease patient with recurrent epididymitis. ( 26593126 )
2016
30
Epididymitis: What You Should Know. ( 27929255 )
2016
31
Epididymitis with Epididymal Cyst Indicating Immunoglobulin A Vasculitis in an AdultAi Nanbu, Kazumitsu Sugiura, Naoto Sassa, Masashi Akiyama. ( 26911283 )
2016
32
Septic Pulmonary Emboli Associated with Klebsiella Pneumoniae Epididymitis. ( 26443643 )
2016
33
A case of testicular infarction from the complications of Klebsiella oxytoca induced acute epididymitis. ( 26643901 )
2016
34
Embryonal rhabdomyosarcoma of the epididymis presenting as epididymitis: A case report. ( 27073679 )
2016
35
Epididymitis: An Overview. ( 27929243 )
2016
36
Epididymitis following Cytoreductive Surgery with Intraperitoneal Oxaliplatin Chemotherapy: Two Case Reports. ( 27293401 )
2016
37
Re: Epididymitis: Ascending Infection Restricted by Segmental Boundaries. ( 27302810 )
2016
38
Tuberculous Epididymitis. ( 25945724 )
2015
39
Early diagnosis of testicular torsion in rats by measuring plasma d-dimer levels: comparative study with epididymitis. ( 25840081 )
2015
40
Re: Adrian Pilatz, Hamid Hossain, Rolf Kaiser, et al. Acute Epididymitis Revisited: Impact of Molecular Diagnostics on Etiology and Contemporary Guideline Recommendations Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2014.12.005. ( 25864158 )
2015
41
Contagious epididymitis due to Brucella ovis: relationship between sexual function, serology and bacterial shedding in semen. ( 26025374 )
2015
42
Orchitis and Epididymitis in Koalas (Phascolarctos cinereus) Infected With Chlamydia pecorum. ( 25637084 )
2015
43
Epididymitis. ( 26602616 )
2015
44
Epididymitis: revelations at the convergence of clinical and basic sciences. ( 26112484 )
2015
45
Epididymitis: ascending infection restricted by segmental boundaries. ( 25994666 )
2015
46
Acute epididymitis: what you think is not always what you get. ( 26001613 )
2015
47
Tuberculous Epididymitis: A Case of Tuberculous Epididymitis That Was the Presenting Manifestation of Extrapulmonary and Pulmonary Tuberculoses. ( 25851823 )
2015
48
Ectopic Ureteral Insertion into the Seminal Vesicle Causing Recurrent Epididymitis in a 24-Year-Old. ( 27579376 )
2015
49
Amiodarone induced epididymitis: a case report. ( 24719709 )
2014
50
Ectopic ureter, renal dysplasia, and recurrent epididymitis in an infant: case report and review of the literature. ( 25356227 )
2014

Variations for Epididymitis

Expression for Epididymitis

Search GEO for disease gene expression data for Epididymitis.

Pathways for Epididymitis

Pathways related to Epididymitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ARSI CCT5 CGB3 INHBB KLK3 TUBB4B

GO Terms for Epididymitis

Cellular components related to Epididymitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CGB3 CRISP2 CRP INHBB KLK3
2 extracellular region GO:0005576 9.1 ARSI CGB3 CRP INHBB KLK3 TUBB4B

Biological processes related to Epididymitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fat cell differentiation GO:0045444 8.96 INHBB PID1
2 cellular response to leptin stimulus GO:0044320 8.62 INHBB PID1

Sources for Epididymitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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