MCID: EPD018
MIFTS: 31

Epididymo-Orchitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymo-Orchitis

MalaCards integrated aliases for Epididymo-Orchitis:

Name: Epididymo-Orchitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9401
ICD9CM 36 604 604.90
SNOMED-CT 69 24084007
ICD10 34 N45 N45.3
UMLS 74 C0149881

Summaries for Epididymo-Orchitis

MalaCards based summary : Epididymo-Orchitis is related to acute gonococcal epididymo-orchitis and orchitis. An important gene associated with Epididymo-Orchitis is PDCD11 (Programmed Cell Death 11), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include testis, prostate and kidney.

Related Diseases for Epididymo-Orchitis

Diseases related to Epididymo-Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 acute gonococcal epididymo-orchitis 12.7
2 orchitis 11.4
3 mumps 10.7
4 brucellosis 10.7
5 prostatitis 10.5
6 bladder cancer 10.4
7 testicular torsion 10.4
8 tuberculous epididymitis 10.4
9 scrub typhus 10.4
10 leukemia 10.3
11 spinal cord injury 10.3
12 inguinal hernia 10.3
13 salmonellosis 10.3
14 acute cystitis 10.3
15 relapsing polychondritis 10.3
16 adenocarcinoma 10.3
17 prostate cancer 10.2
18 anus, imperforate 10.2
19 cryptorchidism, unilateral or bilateral 10.2
20 prostate cancer, hereditary, 8 10.2
21 leukemia, chronic myeloid 10.2
22 prostate cancer, hereditary, 6 10.2
23 testicular microlithiasis 10.2
24 kawasaki disease 10.2
25 leukemia, acute lymphoblastic 10.2
26 melioidosis 10.2
27 neutropenia 10.2
28 severe congenital neutropenia 10.2
29 parotitis 10.2
30 lymphocytic leukemia 10.2
31 hypospadias 10.2
32 chlamydia 10.2
33 choledocholithiasis 10.2
34 dementia 10.2
35 histoplasmosis 10.2
36 urethral stricture 10.2
37 leiomyosarcoma 10.2
38 rectum cancer 10.2
39 nocardiosis 10.2
40 acute pancreatitis 10.2
41 teratoma 10.2
42 purpura 10.2
43 seminoma 10.2
44 pancreatitis 10.2
45 appendicitis 10.2
46 herpes simplex 10.2
47 meningitis 10.2
48 hydrocele 10.2
49 candida glabrata 10.2
50 duplication of urethra 10.2

Comorbidity relations with Epididymo-Orchitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Ischemic Heart Disease Prostate Cancer
Prostatic Hypertrophy Prostatitis
Urethral Stricture

Graphical network of the top 20 diseases related to Epididymo-Orchitis:



Diseases related to Epididymo-Orchitis

Symptoms & Phenotypes for Epididymo-Orchitis

Drugs & Therapeutics for Epididymo-Orchitis

Search Clinical Trials , NIH Clinical Center for Epididymo-Orchitis

Genetic Tests for Epididymo-Orchitis

Anatomical Context for Epididymo-Orchitis

MalaCards organs/tissues related to Epididymo-Orchitis:

42
Testis, Prostate, Kidney, Bone, Testes, Spinal Cord, Bone Marrow

Publications for Epididymo-Orchitis

Articles related to Epididymo-Orchitis:

(show top 50) (show all 287)
# Title Authors Year
1
Brucellar epididymo-orchitis: a retrospective study of 25 cases. ( 30767606 )
2019
2
Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh. ( 30771193 )
2019
3
Neonatal epididymo-orchitis: An unusual manifestation of salmonellosis. ( 30817268 )
2019
4
Unusual cause for recurrent epididymo-orchitis: fistula from rectal stump to seminal vesicle. ( 30839146 )
2019
5
Correction to: Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh. ( 30911901 )
2019
6
Nonhealing scrotal ulceration-an unusual manifestation of TB epididymo-orchitis: case report and review of literature. ( 29375854 )
2018
7
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
8
Non-traumatic testicular rupture following episode of epididymo-orchitis. ( 29367897 )
2018
9
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
10
Epididymo-orchitis caused by enteric organisms in men >a8835A years old: beyond fluoroquinolones. ( 29450767 )
2018
11
Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis. ( 29697933 )
2018
12
Scrotal abscess consequent on syphilitic epididymo-orchitis. ( 30394857 )
2018
13
Salmonella epididymo-orchitis presenting as acute scrotum in a 2-week-old infant. ( 30407675 )
2018
14
Staphylococcus haemolyticus epididymo-orchitis and bacteraemia: a case report. ( 30275960 )
2018
15
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2017
16
Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient. ( 29340471 )
2017
17
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
18
Neonatal epididymo-orchitis with pyocele caused by Escherichia coli: Successful treatment with antimicrobial therapy alone. ( 29224998 )
2017
19
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
20
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
21
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
22
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
23
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
24
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
25
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease. ( 29034643 )
2017
26
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
27
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
28
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. ( 27472731 )
2016
29
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
30
First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? ( 27672563 )
2016
31
The clinical and laboratory characteristics, treatments, and outcomes of patients with Brucella epididymo-orchitis (BEO) compared to those without BEO. ( 27966338 )
2016
32
Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. ( 27602327 )
2016
33
Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. ( 27246506 )
2016
34
ASSOCIATION OF MEAN PLATELET VOLUME AND THE MONOCYTE/LYMPHOCYTE RATIO WITH BRUCELLA-CAUSED EPIDIDYMO-ORCHITIS. ( 27405128 )
2016
35
A Case of Epididymo-orchitis after intravesical bacille Calmette-GuAcrin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection. ( 27257433 )
2016
36
Testicular infarction and rupture: an uncommon complication of epididymo-orchitis. ( 27165751 )
2016
37
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
38
Tuberculous epididymo-orchitis masquerading as acute scrotum. ( 26847806 )
2016
39
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2016
40
Unilateral Tuberculous Epididymo- Orchitis with Scrotal Fistula: a Case Report. ( 26351479 )
2015
41
Distribution of Epididymal Involvement in Mumps Epididymo-orchitis. ( 26014328 )
2015
42
Testicular loss following bacterial epididymo-orchitis: Case report and literature review. ( 25844104 )
2015
43
Surgically Confirmed Intra- and Extratesticular Hematoma Clinically Mimicing Epididymo-Orchitis and Radiologically Mimicing Traumatic Torsion. ( 26600877 )
2015
44
Tuberculous epididymo-orchitis: A difficult diagnosis. ( 25626956 )
2015
45
BehAset's Disease Detecting by Attacks of Recurrent Epididymo-Orchitis: Case Reports. ( 26571326 )
2015
46
Emphysematous epididymo-orchitis. ( 25709173 )
2015
47
Intratesticular and scrotal wall air: Emphysematous epididymo-orchitis or Fournier's gangrene: A dilemma. ( 25709172 )
2015
48
IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. ( 24261777 )
2014
49
Isolation of Actinobacillus seminis from a goat with clinical epididymo-orchitis in Brazil. ( 24948932 )
2014
50
A case of childhood Brucellosis with neurological involvement and epididymo-orchitis. ( 25500664 )
2014

Variations for Epididymo-Orchitis

Expression for Epididymo-Orchitis

Search GEO for disease gene expression data for Epididymo-Orchitis.

Pathways for Epididymo-Orchitis

GO Terms for Epididymo-Orchitis

Cellular components related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 CCT5 TCP1
2 chaperonin-containing T-complex GO:0005832 8.96 CCT5 TCP1
3 activin receptor complex GO:0048179 8.62 ACVR1B ACVR2B

Biological processes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor signaling pathway GO:0007179 9.52 ACVR1B ACVR2B
2 pattern specification process GO:0007389 9.51 ACVR1B ACVR2B
3 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.49 ACVR1B INHBB
4 regulation of signal transduction GO:0009966 9.48 ACVR1B ACVR2B
5 binding of sperm to zona pellucida GO:0007339 9.46 CCT5 TCP1
6 toxin transport GO:1901998 9.43 CCT5 TCP1
7 positive regulation of telomere maintenance via telomerase GO:0032212 9.4 CCT5 TCP1
8 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.37 ACVR1B ACVR2B
9 positive regulation of telomerase RNA localization to Cajal body GO:1904874 9.32 CCT5 TCP1
10 positive regulation of establishment of protein localization to telomere GO:1904851 9.26 CCT5 TCP1
11 positive regulation of protein localization to Cajal body GO:1904871 9.16 CCT5 TCP1
12 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR1B ACVR2B
13 activin receptor signaling pathway GO:0032924 8.8 ACVR1B ACVR2B INHBB

Molecular functions related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ACVR1B ACVR2B CCT5 CRP INHBB PDCD11
2 SMAD binding GO:0046332 9.32 ACVR1B ACVR2B
3 growth factor binding GO:0019838 9.26 ACVR1B ACVR2B
4 transforming growth factor beta-activated receptor activity GO:0005024 9.16 ACVR1B ACVR2B
5 activin binding GO:0048185 8.96 ACVR1B ACVR2B
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 ACVR1B ACVR2B

Sources for Epididymo-Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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