MCID: EPD018
MIFTS: 31

Epididymo-Orchitis

Categories: Reproductive diseases
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Aliases & Classifications for Epididymo-Orchitis

MalaCards integrated aliases for Epididymo-Orchitis:

Name: Epididymo-Orchitis 11 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:9401
ICD9CM 34 604
SNOMED-CT 68 24084007
UMLS 71 C0149881

Summaries for Epididymo-Orchitis

MalaCards based summary: Epididymo-Orchitis is related to orchitis and urogenital tuberculosis. An important gene associated with Epididymo-Orchitis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Overview of nanoparticle effects. Affiliated tissues include testis, prostate and spinal cord, and related phenotype is reproductive system.

Wikipedia: 75 Epididymitis is a medical condition characterized by inflammation of the epididymis, a curved structure... more...

Related Diseases for Epididymo-Orchitis

Diseases related to Epididymo-Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 orchitis 31.6 ZAN TEX11 IL6 CRP
2 urogenital tuberculosis 31.2 KLK3 CRP
3 testicular torsion 31.2 CST9L CRP AFP
4 urinary tract infection 31.2 KLK3 IL6 CRP
5 urethral stricture 31.1 KLK3 CRP
6 infected hydrocele 31.0 CRP AFP
7 testicular infarct 31.0 LYPD8 DEFB121 CRP AFP
8 tuberculous epididymitis 30.9 KLK3 CRP AFP
9 urethritis 30.7 KLK3 IL6 CRP
10 granulomatous orchitis 30.7 ZAN AFP
11 testicular cancer 30.7 KLK3 DAZL AFP
12 pyuria 30.7 KLK3 IL6 CRP
13 hematocele of tunica vaginalis testis 30.5 CRP AFP
14 relapsing polychondritis 30.5 IL6 CRP
15 inguinal hernia 30.5 KLK3 IL6 CRP AFP
16 prostatic hypertrophy 30.3 KLK3 CRP
17 inappropriate adh syndrome 30.2 IL6 CRP
18 necrotizing fasciitis 30.2 IL6 CRP
19 cryptorchidism, unilateral or bilateral 30.1 TNP2 TEX11 DAZL AFP
20 oligospermia 30.0 TNP2 TEX11 DAZL
21 testicular disease 29.8 KLK3 IL6 DAZL AFP
22 acute gonococcal epididymo-orchitis 11.6
23 brucellosis 10.8
24 mumps 10.6
25 bladder cancer 10.5
26 chlamydia 10.5
27 hydrocele 10.5
28 prostatitis 10.5
29 bacteremia 2 10.5
30 atrophy of testis 10.4
31 extrapulmonary tuberculosis 10.4
32 liver inflammatory pseudotumor 10.3 CRP AFP
33 pineal region meningioma 10.3 CRP AFP
34 tuberculous peritonitis 10.3 CRP AFP
35 anus, imperforate 10.3
36 neurogenic bladder 10.3
37 gastrointestinal tuberculosis 10.3 CRP AFP
38 abdominal tuberculosis 10.3 CRP AFP
39 pineal dysgerminoma 10.3 KLK3 AFP
40 glossopharyngeal nerve paralysis 10.3 KLK3 AFP
41 anal fistula 10.3 CRP AFP
42 gummatous syphilis 10.3 CRP AFP
43 ureterolithiasis 10.3 KLK3 CRP
44 drug-induced hepatitis 10.3 CRP AFP
45 cholecystolithiasis 10.3 CRP AFP
46 common bile duct disease 10.3 CRP AFP
47 epididymis adenocarcinoma 10.3 KLK3 AFP
48 epididymis cancer 10.3 KLK3 AFP
49 intrahepatic bile duct adenoma 10.3 KLK3 AFP
50 behcet syndrome 10.3

Comorbidity relations with Epididymo-Orchitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Prostate Cancer Prostatic Hypertrophy
Prostatitis Urethral Stricture

Graphical network of the top 20 diseases related to Epididymo-Orchitis:



Diseases related to Epididymo-Orchitis

Symptoms & Phenotypes for Epididymo-Orchitis

MGI Mouse Phenotypes related to Epididymo-Orchitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.23 AFP CRISP1 CST9L DAZL IL6 TEX11

Drugs & Therapeutics for Epididymo-Orchitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Unknown status NCT03969979

Search NIH Clinical Center for Epididymo-Orchitis

Genetic Tests for Epididymo-Orchitis

Anatomical Context for Epididymo-Orchitis

Organs/tissues related to Epididymo-Orchitis:

MalaCards : Testis, Prostate, Spinal Cord, Kidney, Bone Marrow, Testes, Bone

Publications for Epididymo-Orchitis

Articles related to Epididymo-Orchitis:

(show top 50) (show all 708)
# Title Authors PMID Year
1
Urological Impact of Epididymo-orchitis in Patients with Anorectal Malformation: An ARM-Net Consortium Study. 62
35073590 2022
2
Epididymo-orchitis secondary to colovesical fistula. 62
36438455 2022
3
Tuberculosis Epididymo-Orchitis Mimicking Malignancy Resulting from Intravesical Bacillus Calmette-Guérin Immunotherapy for Bladder Cancer: A Case Report of a Rare Complication. 62
36359505 2022
4
Torsion of the spermatic cord in adults: a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion. 62
35322657 2022
5
Pediatric Non-Testicular Torsion Acute Scrotum-Is the Use of Prophylactic Antibiotics in Patients With Normal Urine Analysis Justified? 62
35878814 2022
6
Clinical spectrum and management options for prostatic utricle in children. 62
35101262 2022
7
Antineutrophil cytoplasmic antibody associated vasculitis: a converging diagnosis from neuropathy and testicular infarcts. 62
36452284 2022
8
EPIDIDYMO-ORCHITIS LEADING TO GLOBAL TESTICULAR INFARCTION IN A PEDIATRIC PATIENT - A CASE REPORT. 62
36450319 2022
9
Sonographic findings of COVID-19 related acute scrotal infection and associations with clinical-laboratory data. 62
35775362 2022
10
Incidental Tuberculosis Epididymitis/Epididymo-orchitis: A Retrospective Analysis at a Tertiary Center in Taiwan. 62
35798186 2022
11
Epididymo-orchitis caused by Histoplasma capsulatum. 62
35651534 2022
12
Epididymo-Orchitis and Pelvic Abscess in a Patient With Inflatable Penile Prosthesis. 62
36320940 2022
13
Testicular Plasmacytoma Masking as Epididymo-orchitis in a Known Multiple Myeloma Patient. 62
36060019 2022
14
Is testicular microlithiasis associated with testicular pathologies in children? 62
35829746 2022
15
The Pseudo-Bladder: A Case of the Prostatic Urethra Masquerading as the Bladder. 62
36179861 2022
16
A simplified ultrasound approach to diagnose testicular torsion and predict unsalvageable testis. 62
35437523 2022
17
Presentations of the Acute Scrotum During the COVID-19 Pandemic: Experiences of a Non-urological Centre. 62
36127974 2022
18
Minor lobulation of the testis, mimicking polyorchidism when inflammed, discussion of a rare case: A case report. 62
35907296 2022
19
Sodium-glucose cotransporter 2 inhibitor-associated severe epididymo-orchitis. 62
35817490 2022
20
Newer Insights into Prostatic Utricle in Proximal Hypospadias. 62
36238343 2022
21
Segmental Testicular Infarction: A Case Report. 62
35865444 2022
22
Segmental testicular infarct with an associated testicular artery aneurysm: Case report of a rare clinical entity. 62
35469300 2022
23
An unusual location of hand, foot and mouth disease. 62
33743167 2022
24
Alveolar Paratesticular Rhabdomyosarcoma in an Adult Patient Mimicking Epididymo-Orchitis: A Case Report and a Literature Review. 62
35673308 2022
25
Isolated tuberculous orchitis presented as epididymo-orchitis: An unusual presentation of tuberculosis. 62
35711493 2022
26
Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility. 62
34169683 2022
27
Testicular torsion - symptomatology and outcomes of 101 scrotal explorations. 62
35711480 2022
28
First Case of Bacteremia and Epididymo-orchitis Caused by Oceanobacillus oncorhynchi subspecies incaldanensis in an Immunocompetent Patient. 62
34635623 2022
29
[Practice of urological departments during the COVID-19 pandemic]. 62
35274856 2022
30
Xanthogranulomatous epididymo-orchitis: A case report with review of the literature. 62
35220165 2022
31
Emphysematous epididymo-orchitis: imaging plays a vital part in active management: case report and literature review. 62
35280055 2022
32
Acute Epididymo-Orchitis as a Rare Cause of Testicular Infarction. 62
34929242 2022
33
Testicular infarction and spontaneous scrotal rupture secondary to acute epididymo-orchitis. 62
35246433 2022
34
Pathogenesis of Brucella epididymoorchitis-game of Brucella death. 62
34214000 2022
35
Epididymo-Orchitis: A Rare Manifestation of MIS-C. 62
34731439 2022
36
Testicular Necrosis Post Kidney Transplantation: Lessons Learned. 62
35012762 2022
37
Unusual presentation of a periurethral abscess following infection with Neisseria gonorrhoea. 62
34983811 2022
38
Abdominal pain in children with COVID-19. 62
36223151 2022
39
Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19. 62
35795005 2022
40
Testicular necrosis as a complication of severe epididymo-orchitis: a case report. 62
36160277 2022
41
Pediatric intratesticular abscess managed with a testicular sparing approach: A case report. 62
34660205 2022
42
Evaluating the Necessity of Antibiotics in the Treatment of Acute Epididymitis in Pediatric Patients: A Literature Review of Retrospective Studies and Data Analysis. 62
28099292 2021
43
Acute Bacterial Epididymo-Orchitis Caused by Mycobacterium tuberculosis. 62
34388033 2021
44
A Rare Case of Prostatic Utricle with Crossover Vas Deferens in Children. 62
35056348 2021
45
Spontaneous Bilateral Spermatic Vein Thrombosis: A Rare Clinical Presentation. 62
35003990 2021
46
Complicated diverticular disease presenting as recurrent epididymo-orchitis: a case report. 62
33734549 2021
47
Right-sided varicocele thrombosis complicating an acute epididymo-orchitis: A case report and review of the literature. 62
34221898 2021
48
Surgical management of tuberculous epididymo-orchitis: a retrospective study of 81 cases with long-term follow-up. 62
34654377 2021
49
Ectopic Vas Deferens Causing Recurrent Epididymo-Orchitis. 62
34363814 2021
50
The Scrotum Narrates the Inside Story…. 62
34728921 2021

Variations for Epididymo-Orchitis

Expression for Epididymo-Orchitis

Search GEO for disease gene expression data for Epididymo-Orchitis.

Pathways for Epididymo-Orchitis

Pathways related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 IL6 CRP

GO Terms for Epididymo-Orchitis

Cellular components related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 ZAN LYPD8 KLK3 IL6 CST9L CRP
2 extracellular region GO:0005576 9.5 LYPD8 KLK3 IL6 DEFB121 DEFB114 CST9L

Biological processes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.43 LYPD8 IL6 DEFB114
2 negative regulation of lipid storage GO:0010888 8.92 IL6 CRP

Sources for Epididymo-Orchitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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