MCID: EPD018
MIFTS: 35

Epididymo-Orchitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymo-Orchitis

MalaCards integrated aliases for Epididymo-Orchitis:

Name: Epididymo-Orchitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9401
ICD10 33 N45 N45.3
ICD9CM 35 604 604.90
SNOMED-CT 68 24084007
UMLS 73 C0149881

Summaries for Epididymo-Orchitis

MalaCards based summary : Epididymo-Orchitis is related to epididymitis and acute gonococcal epididymo-orchitis. An important gene associated with Epididymo-Orchitis is PDCD11 (Programmed Cell Death 11), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include testis, prostate and kidney.

Related Diseases for Epididymo-Orchitis

Diseases related to Epididymo-Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 epididymitis 29.8 CCT5 CRP INHBB PDCD11 TNP1
2 acute gonococcal epididymo-orchitis 12.7
3 orchitis 11.4
4 mumps 10.6
5 brucellosis 10.6
6 prostatitis 10.4
7 bladder cancer 10.4
8 testicular torsion 10.4
9 tuberculous epididymitis 10.4
10 scrub typhus 10.4
11 spinal cord injury 10.3
12 inguinal hernia 10.3
13 acute cystitis 10.3
14 relapsing polychondritis 10.3
15 adenocarcinoma 10.3
16 prostate cancer 10.1
17 anus, imperforate 10.1
18 cryptorchidism, unilateral or bilateral 10.1
19 leukemia, chronic myeloid 10.1
20 testicular microlithiasis 10.1
21 kawasaki disease 10.1
22 leukemia, acute lymphoblastic 10.1
23 melioidosis 10.1
24 leukemia 10.1
25 neutropenia 10.1
26 severe congenital neutropenia 10.1
27 salmonellosis 10.1
28 parotitis 10.1
29 lymphocytic leukemia 10.1
30 hypospadias 10.1
31 chlamydia 10.1
32 choledocholithiasis 10.1
33 dementia 10.1
34 histoplasmosis 10.1
35 urethral stricture 10.1
36 endodermal sinus tumor 10.1
37 leiomyosarcoma 10.1
38 nocardiosis 10.1
39 acute pancreatitis 10.1
40 teratoma 10.1
41 purpura 10.1
42 seminoma 10.1
43 pancreatitis 10.1
44 appendicitis 10.1
45 herpes simplex 10.1
46 viral infectious disease 10.1
47 meningitis 10.1
48 hydrocele 10.1
49 candida glabrata 10.1
50 duplication of urethra 10.1

Comorbidity relations with Epididymo-Orchitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Ischemic Heart Disease Prostate Cancer
Prostatic Hypertrophy Prostatitis
Urethral Stricture

Graphical network of the top 20 diseases related to Epididymo-Orchitis:



Diseases related to Epididymo-Orchitis

Symptoms & Phenotypes for Epididymo-Orchitis

Drugs & Therapeutics for Epididymo-Orchitis

Search Clinical Trials , NIH Clinical Center for Epididymo-Orchitis

Genetic Tests for Epididymo-Orchitis

Anatomical Context for Epididymo-Orchitis

MalaCards organs/tissues related to Epididymo-Orchitis:

41
Testis, Prostate, Kidney, Bone, Testes, Spinal Cord, Myeloid

Publications for Epididymo-Orchitis

Articles related to Epididymo-Orchitis:

(show top 50) (show all 282)
# Title Authors Year
1
Nonhealing scrotal ulceration-an unusual manifestation of TB epididymo-orchitis: case report and review of literature. ( 29375854 )
2018
2
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
3
Non-traumatic testicular rupture following episode of epididymo-orchitis. ( 29367897 )
2018
4
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
5
Epididymo-orchitis caused by enteric organisms in men >a8835A years old: beyond fluoroquinolones. ( 29450767 )
2018
6
Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis. ( 29697933 )
2018
7
Staphylococcus haemolyticus epididymo-orchitis and bacteraemia: a case report. ( 30275960 )
2018
8
Scrotal abscess consequent on syphilitic epididymo-orchitis. ( 30394857 )
2018
9
Salmonella epididymo-orchitis presenting as acute scrotum in a 2-week-old infant. ( 30407675 )
2018
10
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2017
11
Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient. ( 29340471 )
2017
12
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
13
Neonatal epididymo-orchitis with pyocele caused by Escherichia coli: Successful treatment with antimicrobial therapy alone. ( 29224998 )
2017
14
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
15
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
16
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
17
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
18
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
19
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
20
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease. ( 29034643 )
2017
21
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
22
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
23
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2017
24
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. ( 27472731 )
2016
25
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
26
First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? ( 27672563 )
2016
27
The clinical and laboratory characteristics, treatments, and outcomes of patients with Brucella epididymo-orchitis (BEO) compared to those without BEO. ( 27966338 )
2016
28
Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. ( 27602327 )
2016
29
Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. ( 27246506 )
2016
30
ASSOCIATION OF MEAN PLATELET VOLUME AND THE MONOCYTE/LYMPHOCYTE RATIO WITH BRUCELLA-CAUSED EPIDIDYMO-ORCHITIS. ( 27405128 )
2016
31
A Case of Epididymo-orchitis after intravesical bacille Calmette-GuAcrin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection. ( 27257433 )
2016
32
Testicular infarction and rupture: an uncommon complication of epididymo-orchitis. ( 27165751 )
2016
33
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
34
Tuberculous epididymo-orchitis masquerading as acute scrotum. ( 26847806 )
2016
35
Unilateral Tuberculous Epididymo- Orchitis with Scrotal Fistula: a Case Report. ( 26351479 )
2015
36
Distribution of Epididymal Involvement in Mumps Epididymo-orchitis. ( 26014328 )
2015
37
Testicular loss following bacterial epididymo-orchitis: Case report and literature review. ( 25844104 )
2015
38
Surgically Confirmed Intra- and Extratesticular Hematoma Clinically Mimicing Epididymo-Orchitis and Radiologically Mimicing Traumatic Torsion. ( 26600877 )
2015
39
Tuberculous epididymo-orchitis: A difficult diagnosis. ( 25626956 )
2015
40
BehAset's Disease Detecting by Attacks of Recurrent Epididymo-Orchitis: Case Reports. ( 26571326 )
2015
41
Emphysematous epididymo-orchitis. ( 25709173 )
2015
42
Intratesticular and scrotal wall air: Emphysematous epididymo-orchitis or Fournier's gangrene: A dilemma. ( 25709172 )
2015
43
IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. ( 24261777 )
2014
44
Isolation of Actinobacillus seminis from a goat with clinical epididymo-orchitis in Brazil. ( 24948932 )
2014
45
A case of childhood Brucellosis with neurological involvement and epididymo-orchitis. ( 25500664 )
2014
46
Synchronous infection of the aorta and the testis: emphysematous epididymo-orchitis, abdominal aortic mycotic aneurysm, and testicular artery pseudoaneurysm diagnosed by use of MDCT. ( 24737146 )
2014
47
Brucellar epididymo-orchitis: a retrospective multicenter study of 28 cases and review of the literature. ( 25457303 )
2014
48
FDG PET/CT Images Demonstrating Epididymo-Orchitis in a Patient With HIV, Acute Kidney Injury and Known Epididymo-Orchitis on Scrotal Ultrasound. ( 25247269 )
2014
49
Epididymo-orchitis: a rare manifestation of scrub typhus in a child. ( 24717207 )
2014
50
Spermatic cord abscess: a rare complication of epididymo-orchitis, the diagnosis and management. ( 25096656 )
2014

Variations for Epididymo-Orchitis

Expression for Epididymo-Orchitis

Search GEO for disease gene expression data for Epididymo-Orchitis.

Pathways for Epididymo-Orchitis

GO Terms for Epididymo-Orchitis

Cellular components related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 CCT5 TCP1
2 chaperonin-containing T-complex GO:0005832 8.96 CCT5 TCP1
3 activin receptor complex GO:0048179 8.62 ACVR1B ACVR2B

Biological processes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor signaling pathway GO:0007179 9.52 ACVR1B ACVR2B
2 pattern specification process GO:0007389 9.51 ACVR1B ACVR2B
3 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.49 ACVR1B INHBB
4 regulation of signal transduction GO:0009966 9.48 ACVR1B ACVR2B
5 binding of sperm to zona pellucida GO:0007339 9.46 CCT5 TCP1
6 toxin transport GO:1901998 9.43 CCT5 TCP1
7 positive regulation of telomere maintenance via telomerase GO:0032212 9.4 CCT5 TCP1
8 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.37 ACVR1B ACVR2B
9 positive regulation of telomerase RNA localization to Cajal body GO:1904874 9.32 CCT5 TCP1
10 positive regulation of establishment of protein localization to telomere GO:1904851 9.26 CCT5 TCP1
11 positive regulation of protein localization to Cajal body GO:1904871 9.16 CCT5 TCP1
12 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR1B ACVR2B
13 activin receptor signaling pathway GO:0032924 8.8 ACVR1B ACVR2B INHBB

Molecular functions related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ACVR1B ACVR2B CCT5 CRP INHBB PDCD11
2 SMAD binding GO:0046332 9.32 ACVR1B ACVR2B
3 growth factor binding GO:0019838 9.26 ACVR1B ACVR2B
4 transforming growth factor beta-activated receptor activity GO:0005024 9.16 ACVR1B ACVR2B
5 activin binding GO:0048185 8.96 ACVR1B ACVR2B
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 ACVR1B ACVR2B

Sources for Epididymo-Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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