MCID: EPD018
MIFTS: 31

Epididymo-Orchitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymo-Orchitis

MalaCards integrated aliases for Epididymo-Orchitis:

Name: Epididymo-Orchitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9401
ICD9CM 34 604
SNOMED-CT 67 24084007
ICD10 32 N45.3
UMLS 70 C0149881

Summaries for Epididymo-Orchitis

MalaCards based summary : Epididymo-Orchitis is related to orchitis and urethritis. An important gene associated with Epididymo-Orchitis is CRP (C-Reactive Protein). Affiliated tissues include testis, prostate and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Epididymitis is a medical condition characterized by inflammation of the epididymis, a curved structure... more...

Related Diseases for Epididymo-Orchitis

Diseases related to Epididymo-Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 orchitis 32.3 CRP CRISP1
2 urethritis 30.8 KLK3 CRP
3 acute cystitis 30.8 KLK3 CRP
4 pyuria 30.7 KLK3 CRP
5 tuberculous epididymitis 30.5 KLK3 CRP AFP
6 hematocele of tunica vaginalis testis 30.4 CRP AFP
7 neurogenic bladder 30.4 KLK3 CRP
8 endodermal sinus tumor 30.0 KLK3 AFP
9 testicular infarct 29.9 CRP AFP ADA2
10 oligospermia 29.6 TNP2 TNP1 DAZL
11 acute gonococcal epididymo-orchitis 11.6
12 brucellosis 10.7
13 testicular torsion 10.6
14 urinary tract infection 10.6
15 mumps 10.6
16 chlamydia 10.5
17 hydrocele 10.5
18 prostatitis 10.5
19 bladder cancer 10.4
20 disease by infectious agent 10.4
21 urethral stricture 10.4
22 extrapulmonary tuberculosis 10.4
23 inguinal hernia 10.4
24 pineal region meningioma 10.3 CRP AFP
25 liver inflammatory pseudotumor 10.3 CRP AFP
26 infected hydrocele 10.3 CRP AFP
27 basidiobolomycosis 10.3 CRP AFP
28 common bile duct disease 10.3 CRP AFP
29 mycobacterium tuberculosis 1 10.3
30 epidemic typhus 10.3
31 scrub typhus 10.3
32 vasculitis 10.3
33 spinal cord injury 10.3
34 abdominal tuberculosis 10.3 CRP AFP
35 anal fistula 10.2 CRP AFP
36 hepatic tuberculosis 10.2 CRP AFP
37 embryonal testis carcinoma 10.2 TNP2 AFP
38 plasma protein metabolism disease 10.2 CRP AFP
39 portal vein thrombosis 10.2 CRP AFP
40 hepatic vascular disease 10.2 CRP AFP
41 anus, imperforate 10.2
42 salmonellosis 10.2
43 parotitis 10.2
44 interstitial nephritis 10.2
45 hypospadias 10.2
46 prostatic hypertrophy 10.2
47 toxic shock syndrome 10.2
48 bacteriuria 10.2
49 histoplasmosis 10.2
50 nocardiosis 10.2

Comorbidity relations with Epididymo-Orchitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Prostate Cancer Prostatic Hypertrophy
Prostatitis Urethral Stricture

Graphical network of the top 20 diseases related to Epididymo-Orchitis:



Diseases related to Epididymo-Orchitis

Symptoms & Phenotypes for Epididymo-Orchitis

GenomeRNAi Phenotypes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.58 ADA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.58 ADA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.58 ADA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.58 AFP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.58 CRP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.58 ADA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.58 CRP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.58 CRP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 CRP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.58 ADA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.58 ADA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.58 AFP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.58 ADA2 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 CRP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.58 ADA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.58 AFP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.58 ADA2

Drugs & Therapeutics for Epididymo-Orchitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Recruiting NCT03969979

Search NIH Clinical Center for Epididymo-Orchitis

Genetic Tests for Epididymo-Orchitis

Anatomical Context for Epididymo-Orchitis

MalaCards organs/tissues related to Epididymo-Orchitis:

40
Testis, Prostate, Spinal Cord, Bone Marrow, Testes, Liver, Pineal

Publications for Epididymo-Orchitis

Articles related to Epididymo-Orchitis:

(show top 50) (show all 646)
# Title Authors PMID Year
1
Tuberculous epididymo-orchitis secondary to Bacillus Calmette-Guérin (BCG) in non-muscular invasive bladder cancer. 61
33796443 2021
2
A challenging case of surgical management of a single ischemic testicle from severe epididymo-orchitis. 61
33680852 2021
3
SARS-CoV-2 infection affects the lower urinary tract and male genital system: A systematic review. 61
33595134 2021
4
A severe complication of intravesical bacillus Calmette-Guerin: An effect of different strains. 61
33598408 2021
5
Testicular torsion in the medicolegal perspective: Why is the diagnosis missing? 61
33630295 2021
6
An unusual location of hand, foot and mouth disease. 61
33743167 2021
7
Complicated diverticular disease presenting as recurrent epididymo-orchitis: a case report. 61
33734549 2021
8
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
9
Biopsy-confirmed Genitourinary Tuberculosis in a Secondary Health Care Hospital: An Evidence-based Clinical Review. 61
33763390 2021
10
Isolated tuberculosis of testis: A case report. 61
33680408 2021
11
Case Report: A Rare Case of Crimean-Congo Hemorrhagic Fever Associated with Epididymo-Orchitis. 61
33399048 2021
12
A case of acute vasitis mimicking an incarcerated inguinal hernia with subtle imaging findings. 61
33325356 2020
13
Monolateral chronicon orchitis in a stallion. 61
32602673 2020
14
Emphysematous epididymitis following hydrocelectomy. 61
33102060 2020
15
Communicating seminal vesicles leading to indirect vasal communication: A case report. 61
33101990 2020
16
Right-sided scrotal varicocele and its association with malignancy: a multi-institutional study. 61
33151361 2020
17
Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019: A Single-Center-Based Study in Wuhan, China. 61
33174632 2020
18
Testicular tuberculosis: An uncommon complication after treatment of urothelial carcinoma. 61
32983302 2020
19
Acute vasitis presenting as a concerning paratesticular mass in an adolescent, a case report. 61
33102059 2020
20
Candida urinary tract infections in adults. 61
31654220 2020
21
The Spectrum of Testicular Pathologies Upon Scrotal Exploration for Acute Scrotum: A Retrospective Analysis. 61
33209540 2020
22
Is there any association of COVID-19 with testicular pain and epididymo-orchitis? 61
33063899 2020
23
Segmental testicular infarction, a rare complication of epididymo-orchitis. 61
32489887 2020
24
Turquoise Discoloration of Organs on Autopsy Secondary to Treatment of Septic Shock With Methylene Blue. 61
33062547 2020
25
Region-specific immune responses to autoimmune epididymitis in the murine reproductive tract. 61
32383098 2020
26
Gonococcal epididymo-orchitis in an octogenarian. 61
32850096 2020
27
Acute right epididymo-orchitis complicated by pampiniform plexus thrombosis. 61
32322510 2020
28
Imaging of the acute scrotum: keys to a rapid diagnosis of acute scrotal disorders. 61
31748822 2020
29
Testicular Abscess and Ischemia Secondary to Epididymo-orchitis. 61
32775073 2020
30
What is beyond testicular torsion and epididymitis? Rare differential diagnoses of acute scrotal pain in adults: A systematic review. 61
32547738 2020
31
Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. 61
32445735 2020
32
More Than Just Torsion: An Unusual Case of Testicular Pain. 61
31665410 2020
33
Ectopic Intravesical Ejaculatory Ducts: Case Report of Bulking Agent Injection for Treatment of Recurrent Epididymitis in a Patient With Anorectal Malformation. 61
32068109 2020
34
Chlamydia trachomatis elicits TLR3 expression but disrupts the inflammatory signaling down-modulating NFκB and IRF3 transcription factors in human Sertoli cells. 61
32664712 2020
35
Salmonella Typhimurium Triggered Unilateral Epididymo-Orchitis and Splenomegaly in a Holstein Bull in Assiut, Egypt: A Case Report. 61
32344573 2020
36
Comparision of Brucella and Non-Brucella Epididymo-orchitis. 61
32513361 2020
37
Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse. 61
32011693 2020
38
A Curious Case of Blastomyces Osteomyelitis. 61
32337141 2020
39
Predictive value of haematologic parameters in diagnosis of testicular torsion: Evidence from a systematic review and meta-analysis. 61
31782182 2020
40
Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review. 61
32398991 2020
41
Brucellar epididymo-orchitis: a retrospective study of 25 cases. 61
30767606 2020
42
The acute scrotum: Frequency and range of etiologies in a Middle Eastern setting. 61
31303137 2020
43
Etiology and clinical features of epididymo-orchitis: A single-center study in Tehran, Iran. 61
32067623 2020
44
A Review of the Diagnostic Use of Fine-needle Aspiration Cytology for Tuberculosis Epididymo-orchitis: To Do or Not to Do. 61
32038890 2020
45
High index of suspicion for brucellosis in a highly cosmopolitan city in southern China. 61
31914937 2020
46
Assessing the Utility of Ultrasound and Urinalysis for Patients with Possible Epididymo-Orchitis - A Retrospective Study. 61
32214857 2020
47
Case report of bilateral testicular infarction due to severe bilateral epididymo-orchitis: A catastrophic complication causing castration. 61
32688238 2020
48
Unusual cause for recurrent epididymo-orchitis: fistula from rectal stump to seminal vesicle. 61
30839146 2020
49
Testicular ischemia secondary to epididymo-orchitis: A case report. 61
31687342 2019
50
Case Report: Epididymo-Orchitis due to Mycobacterium tuberculosis. 61
31482781 2019

Variations for Epididymo-Orchitis

Expression for Epididymo-Orchitis

Search GEO for disease gene expression data for Epididymo-Orchitis.

Pathways for Epididymo-Orchitis

GO Terms for Epididymo-Orchitis

Cellular components related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 LYPD8 KLK3 CST9L CRP CRISP1 AFP
2 extracellular space GO:0005615 9.17 LYPD8 KLK3 CST9L CRP CRISP1 AFP

Biological processes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 KLK3 AFP ADA2
2 binding of sperm to zona pellucida GO:0007339 9.32 CRISP1 CCT5
3 positive regulation of protein processing GO:0010954 9.16 TNP2 TNP1
4 sexual reproduction GO:0019953 8.96 TNP1 AFP
5 spermatogenesis, exchange of chromosomal proteins GO:0035093 8.62 TNP2 TNP1

Sources for Epididymo-Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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