Epidural Abscess disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Epidural Abscess

MalaCards integrated aliases for Epidural Abscess:

Name: Epidural Abscess ¹¹ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Abscess Epidural ¹¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:11387

MeSH ⁴³ D020802

SNOMED-CT ⁶⁸ 310671007

EFO ¹⁶ EFO_0007260

UMLS ⁷¹ C0270629

Sources

Summaries for Epidural Abscess

Disease Ontology: ¹¹ A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).

MalaCards based summary: Epidural Abscess, also known as abscess epidural, is related to discitis and subdural empyema. An important gene associated with Epidural Abscess is CRP (C-Reactive Protein), and among its related pathways/superpathways are Complement cascade and IL12 signaling mediated by STAT4. Affiliated tissues include spinal cord, brain and bone.

Wikipedia: ⁷⁵ An epidural abscess refers to a collection of pus and infectious material located in the epidural space... more...

Sources

Related Diseases for Epidural Abscess

Diseases related to Epidural Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 796)

#	Related Disease	Score	Top Affiliating Genes
1	discitis	31.8	MED31 CRP ALB
2	subdural empyema	31.1	F2 CRP
3	meningitis	31.0	IFNG CRP ALB
4	intracranial abscess	30.9	CRP CD4
5	cauda equina syndrome	30.8	F3 F2 CRP
6	pyomyositis	30.8	CRP CD4
7	septic arthritis	30.7	CRP CD4 ALB
8	pleural empyema	30.7	F2 CRP CD4 ALB
9	alcohol use disorder	30.5	F2 CRP CD4 ALB
10	endocarditis	30.5	IFNG F2 CRP ALB
11	actinomycosis	30.5	CRP CD4 ALB
12	lemierre's syndrome	30.4	F3 F2 CRP
13	transverse myelitis	30.4	CRP CD4
14	cat-scratch disease	30.4	CRP CD4
15	infective endocarditis	30.4	F3 F2 CRP ALB
16	otitis media	30.3	IFNG CRP ALB
17	aortic aneurysm, familial abdominal, 1	30.3	F3 CRP ALB
18	acute pyelonephritis	30.3	CRP ALB
19	horner's syndrome	30.3	F3 CRP
20	mastoiditis	30.3	F3 F2 CRP CD4
21	thrombophlebitis	30.3	F3 F2 CRP ALB
22	nocardiosis	30.3	CRP CD4
23	orbital cellulitis	30.3	CRP CD4
24	toxic shock syndrome	30.3	IFNG F3 CRP
25	pyelonephritis	30.3	IFNG CRP ALB
26	blastomycosis	30.2	CRP CD4
27	cholecystitis	30.2	F2 CRP ALB
28	meningoencephalitis	30.2	CRP CD4 ALB
29	gas gangrene	30.2	CRP ALB
30	acquired immunodeficiency syndrome	30.2	IFNG CRP CD4 ALB
31	crohn's disease	30.2	IFNG CRP CD4 ALB
32	gastroenteritis	30.2	IFNG CRP ALB
33	necrotizing fasciitis	30.2	F3 F2 CRP ALB
34	urinary tract infection	30.1	F3 F2 CRP CD4 ALB
35	pericoronitis	30.1	F3 CRP
36	aortic aneurysm	30.1	F3 F2 CRP ALB
37	endophthalmitis	30.1	CRP CD4 ALB
38	pneumonia	30.1	IFNG CRP ALB
39	arachnoiditis	30.1	IFNG CRP CD4
40	appendicitis	30.0	IFNG CRP ALB
41	tenosynovitis	30.0	CRP CD4
42	pyuria	30.0	F2 CRP ALB
43	klebsiella pneumonia	30.0	F3 CRP ALB
44	cellulitis	29.9	F3 F2 CRP CD4 ALB
45	typhoid fever	29.9	IFNG F2 CRP ALB
46	mucormycosis	29.9	IFNG CRP CD4
47	intracranial hypertension	29.9	F3 F2 CRP ALB
48	sagittal sinus thrombosis	29.9	F3 F2 CRP
49	paratyphoid fever	29.9	IFNG CRP
50	cerebritis	29.9	CRP CD4 ALB

Graphical network of the top 20 diseases related to Epidural Abscess:

Sources

Symptoms & Phenotypes for Epidural Abscess

Sources

Drugs & Therapeutics for Epidural Abscess

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective Analysis of Spinal Epidural Abscess Associated Outcomes at the University of Kentucky	Recruiting	NCT05464251

Search NIH Clinical Center for Epidural Abscess

Cochrane evidence based reviews: epidural abscess

Sources

Genetic Tests for Epidural Abscess

Sources

Anatomical Context for Epidural Abscess

Organs/tissues related to Epidural Abscess:

MalaCards : Spinal Cord, Brain, Bone, Liver, Prostate, Skin, Lung

Sources

Publications for Epidural Abscess

Articles related to Epidural Abscess:

(show top 50) (show all 2234)

#	Title	Authors	PMID	Year
1	Spondylitis with epidural abscess and spinal tuberculoma as a major cause of myeloradiculopathy: a case report. ⁶²	Buchori E...Sari PP	36457788	2023
2	Nocardia Farcinica Mastoiditis and Epidural Abscess in an Immunocompetent Patient: A Rare Entity. ⁶²	Gkrinia E...Kivekas I	36453208	2022
3	Holospinal epidural abscess caused by Streptococcus anginosus group: a literature review. ⁶²	Maeda K...Ishihara S	36455983	2022
4	Predictors of reoperation after surgery for spinal epidural abscess. ⁶²	Kamalapathy PN...Schwab JH	35738500	2022
5	Microvascular Reconstruction of the Anterior Skull Base. ⁶²	Nwaba A...Ellis MF	35984035	2022
6	Pott Luck. ⁶²	Vaphiades MS...Bilyk JR	36427561	2022
7	Quadriplegia from cervical osteomyelodiscitis with vertebral collapse: A case report. ⁶²	Herrera D...Hughes J	36408081	2022
8	Torcular pseudomass in a 14-month-old child: illustrative case. ⁶²	Villeneuve LM...Jea A	36377131	2022
9	A 60-Year-Old Man with Gingivitis and Poorly Controlled Diabetes Developing Low Back Pain 1 Week Following Recovery from COVID-19 Diagnosed with Spinal Abscess Due to Streptococcus oralis. ⁶²	Chu EC...Shum JSF	36199237	2022
10	Management of Holospinal Epidural Abscess. ⁶²	Tracz J...Witham T	35863647	2022
11	Oral sequential therapy in the treatment of post-surgical epidural abscess and subdural empyema. ⁶²	Rubinan P...Alvarez-Fernandez M	35460496	2022
12	Clinical and financial burden of spinal infections in people who inject drugs. ⁶²	Ananda RA...Woolley I	34028966	2022
13	An 82-year-old man with a prosthetic aortic valve and multimicrobial bacteremia. ⁶²	Zubair SN...Minhas SA	36237290	2022
14	A Rare Case of Salmonella Osteomyelitis in Immunocompetent Toddler Without Risk Factors. ⁶²	Daggett AE...Veesenmeyer AF	36426317	2022
15	Nocardia abscessus epidural abscess. ⁶²	Martinez de Pinillos Sanchez MV...Gordillo Resina MM	35869022	2022
16	The Surgical Management of Holospinal Epidural Abscess: A Case Report and Review on Catheter-Based Irrigation Techniques. ⁶²	Halalmeh DR...Moisi MD	36407233	2022
17	Spinal brucellosis causing spondylodiscitis. ⁶²	Ali Adam A...Adam Osman A	36268353	2022
18	Extensive Spinal Epidural Abscess Resulting in Complete Paraplegia Treated by Selective Laminectomies and Irrigation. ⁶²	Xu T...Xi Y	35732468	2022
19	Minimally Invasive Surgical Treatment of Extensive Spinal Epidural Abscess With Unilateral Laminotomy for Bilateral Decompression Using an Ultrasonic Bone Curette: A Technique Note. ⁶²	Lee CY...Lee YJ	36162797	2022
20	[Treatment for Pyogenic Spondylodiscitis and Spinal Epidural Abscess]. ⁶²	Sasaki M...Kishima H	36128813	2022
21	C-reactive Protein-to-albumin Ratio in Spinal Epidural Abscess: Association with Post-treatment Complications. ⁶²	Lindsey MH...Schoenfeld AJ	35984080	2022
22	Epidural abscess formation with an atypical pathogen following epidural steroid injection: A case report. ⁶²	Lee JY...Han SH	36086689	2022
23	A Case Series of Spinal Infections Following COVID-19: A Delayed Complication. ⁶²	Mohamed Ramlee FA...Tan CN	36277530	2022
24	Pyogenic spondylitis caused by Streptococcus dysgalactiae subspecies equisimilis in a patient with nasopharyngeal cancer. ⁶²	Fujii K...Asada Y	35637129	2022
25	Lemierre's syndrome with cranial epidural abscess complication: A case report. ⁶²	Ibrahim IG...Farah FA	36147177	2022
26	Outcomes of Partial Oral Antibiotic Treatment for Complicated S. aureus Bacteremia in People Who Inject Drugs. ⁶²	Wildenthal JA...Marks LR	36052413	2022
27	Pediatric Brain Abscesses, Epidural Empyemas, and Subdural Empyemas Associated with Streptococcus Species - United States, January 2016-August 2022. ⁶²	Accorsi EK...Cohen AL	36107787	2022
28	Development and Validation of a Predictive Model for Failure of Medical Management in Spinal Epidural Abscesses. ⁶²	Page PS...Brooks NP	35584275	2022
29	Cervical Epidural Abscess: A Blind Spot for Postmortem Computed Tomography. ⁶²	McCarthy S...Garland J	34939948	2022
30	Imaging of Spine Infections. ⁶²	Chianca V...Del Grande F	36103882	2022
31	Revisiting the Role of Intraoperative Ultrasound in Spine Surgery for Extradural Pathologies: Review and Clinical Usage. ⁶²	Rustagi T...Chhabra HS	35504481	2022
32	Streptococcus gallolyticus-related spinal epidural abscess. ⁶²	Agrawal V...Pillai V	35999017	2022
33	[Chronic back pain in axial spondylarthritis : Current diagnostic challenges and treatment possibilities]. ⁶²	Moller B	36044071	2022
34	Triple Threat: A Case of Erysipelothrix rhusiopathiae Septicemia Complicated by Multi-Valvular Endocarditis, Spinal Osteomyelitis, and Septic Embolic Stroke. ⁶²	De Narvaez E...Oehler RL	36106220	2022
35	Diagnostic delays in infectious diseases. ⁶²	Suneja M...Polgreen PM	35073468	2022
36	A Rare Case of Aphasia Caused by Delayed Epidural Abscess 6 Years after Cranioplasty. ⁶²	Kim JH...Kim SW	36140442	2022
37	Post-operative clinical course in children undergoing mastoidectomy due to complicated acute mastoiditis. ⁶²	Ziv O...El-Saied S	34714371	2022
38	Surgical Management of Spinal Epidural Abscess in Elderly Patients: A Comparative Analysis Between Patients 65-79 Years and ≥80 Years with 3-Year Follow-Up. ⁶²	Lenga P...Ishak B	36041723	2022
39	Imaging characteristics and CT sensitivity for pyogenic spinal infections. ⁶²	Shroyer S...Davis WT	35689961	2022
40	Intracranially Extended Sinonasal Undifferentiated Carcinoma: A Case Report and Literature Review. ⁶²	Antoniades E...Patsalas I	35913898	2022
41	Unexpectedly rapid decrease in the size of a spinal epidural abscess after percutaneous posterior pedicle screw fixation without decompression surgery: a case report. ⁶²	Kubota G...Ohtori S	35963854	2022
42	Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge. ⁶²	Ansari F...Yadav T	35981749	2022
43	Decompression only versus fusion in octogenarians with spinal epidural abscesses: early complications, clinical and radiological outcome with 2-year follow-up. ⁶²	Lenga P...Ishak B	35536406	2022
44	Shewanella algae Causing Pediatric Orbital Abscess With Leptomeningitis. ⁶²	Chiou CA...Yoon MK	35170566	2022
45	External Review and Validation of a Spinal Epidural Abscess Predictive Score for Clinical Failure. ⁶²	Page PS...Brooks NP	35472643	2022
46	Further considerations regarding spinal epidural abscess in the ED setting. ⁶²	Long B...Koyfman A	35527096	2022
47	Letter to Editor regarding: "High risk and low prevalence diseases: Spinal epidural abscess". ⁶²	Kitov B...Georgiev A	35513933	2022
48	A Case of Methicillin-Sensitive Staphylococcus aureus (MSSA) Prostate Abscess, Osteomyelitis, and Myositis Associated with MSSA Bacteremia in a 60-Year-Old Patient Presenting with Back Pain. ⁶²	Kilani Y...Shah V	35778821	2022
49	Spontaneous Multiloculated Lumbar Abscess in a Middle-Aged Male With Unexplained Progressive Back Pain and Muscle Weakness. ⁶²	Nyc MA...Woloski JR	36046273	2022
50	Pediatric spinal epidural abscess: recognition and management in the emergency department. ⁶²	Ravandi B...Cho C	35613376	2022

Sources

Genes for Epidural Abscess

Genes related to Epidural Abscess (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRP	C-Reactive Protein	Protein Coding	8.16	DISEASES inferred ¹⁴
2	ALB	Albumin	Protein Coding	5.1	DISEASES inferred ¹⁴
3	CYGB	Cytoglobin	Protein Coding	5.04	DISEASES inferred ¹⁴
4	F2	Coagulation Factor II, Thrombin	Protein Coding	4.68	DISEASES inferred ¹⁴
5	F3	Coagulation Factor III, Tissue Factor	Protein Coding	4.64	DISEASES inferred ¹⁴
6	CDH18	Cadherin 18	Protein Coding	4.54	DISEASES inferred ¹⁴
7	CD4	CD4 Molecule	Protein Coding	4.49	DISEASES inferred ¹⁴
8	IFNG	Interferon Gamma	Protein Coding	4.42	DISEASES inferred ¹⁴
9	PRB2	Proline Rich Protein BstNI Subfamily 2	Protein Coding	4.37	DISEASES inferred ¹⁴
10	MED31	Mediator Complex Subunit 31	Protein Coding	4.28	DISEASES inferred ¹⁴
11	HERC3	HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3	Protein Coding	4.26	DISEASES inferred ¹⁴

Sources

Variations for Epidural Abscess

Sources

Expression for Epidural Abscess

Search GEO for disease gene expression data for Epidural Abscess.

Sources

Pathways for Epidural Abscess

Pathways related to Epidural Abscess according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	11.81	IFNG F2 CRP ALB
2	IL12 signaling mediated by STAT4 ⁶¹	10.75	IFNG CD4
3	IL1 and megakaryocytes in obesity ⁷⁴	10.64	IFNG F2
4	Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction ⁶⁰	10.37	F3 F2 CD4
5	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.33	IFNG CD4

Sources

GO Terms for Epidural Abscess

Sources

Sources for Epidural Abscess

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: EPD005 MIFTS: 32	Epidural Abscess Categories: Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Expand all tables