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MCID: EPD005
MIFTS: 35

Epidural Abscess

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Epidural Abscess

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MalaCards integrated aliases for Epidural Abscess:

Name: Epidural Abscess 12 45 15 17 74
Abscess Epidural 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11387
MeSH 45 D020802
SNOMED-CT 69 61974008
UMLS 74 C0270629
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Summaries for Epidural Abscess

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Disease Ontology : 12 A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).

MalaCards based summary : Epidural Abscess, also known as abscess epidural, is related to discitis and osteomyelitis. An important gene associated with Epidural Abscess is CRP (C-Reactive Protein). The drugs Hydromorphone and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 An epidural abscess refers to a collection of pus and infectious material located in the epidural space... more...

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Related Diseases for Epidural Abscess

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Diseases related to Epidural Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 discitis 32.3 CRP MRI1
2 osteomyelitis 10.7
3 meningitis 10.4
4 pleural empyema 10.3
5 arthritis 10.3
6 sinusitis 10.3
7 endocarditis 10.3
8 paraplegia 10.2
9 subdural empyema 10.2
10 brucellosis 10.2
11 quadriplegia 10.2
12 pyomyositis 10.2
13 septic arthritis 10.2
14 crohn's disease 10.1
15 spondylitis 10.1
16 frontal sinusitis 10.1
17 cauda equina syndrome 10.1
18 gout 10.0
19 actinomycosis 10.0
20 bacterial meningitis 10.0
21 aortic aneurysm, familial abdominal, 1 10.0
22 rheumatoid arthritis 10.0
23 chronic granulomatous disease 10.0
24 mastoiditis 10.0
25 cat-scratch disease 10.0
26 aortic aneurysm 10.0
27 sickle cell anemia 9.9
28 dengue virus 9.9
29 melioidosis 9.9
30 dengue disease 9.9
31 diabetes mellitus 9.9
32 leukemia 9.9
33 infective endocarditis 9.9
34 lymphoma 9.9
35 pain agnosia 9.9
36 thrombosis 9.9
37 sphenoid sinusitis 9.9
38 myelitis 9.9
39 pancreatitis 9.9
40 pneumonia 9.9
41 sickle cell disease 9.9
42 headache 9.9
43 bladder cancer 9.7
44 systemic lupus erythematosus 9.7
45 otitis media 9.7
46 parkinson disease, late-onset 9.7
47 pilonidal sinus 9.7
48 currarino syndrome 9.7
49 pruritic urticarial papules and plaques of pregnancy 9.7
50 torticollis 9.7

Graphical network of the top 20 diseases related to Epidural Abscess:



Diseases related to Epidural Abscess
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Symptoms & Phenotypes for Epidural Abscess

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GenomeRNAi Phenotypes related to Epidural Abscess according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.32 SLC2A9
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 SLC2A9
3 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.32 SLC2A9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.32 SLC2A9
5 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.32 SLC2A9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.32 MRI1 SLC2A9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.32 SLC2A9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 MRI1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.32 SLC2A9
Sources

Drugs & Therapeutics for Epidural Abscess

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Drugs for Epidural Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydromorphone Approved, Illicit Phase 3 466-99-9 5284570
2
Bupivacaine Approved, Investigational Phase 3 38396-39-3, 2180-92-9 2474
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
5
Cefazolin Approved Phase 3 25953-19-9 33255 656510
6
Vancomycin Approved Phase 3 1404-90-6 14969 441141
7 Analgesics Phase 3
8 Analgesics, Opioid Phase 3
9 Narcotics Phase 3
10 Anesthetics Phase 3
11 Anesthetics, Intravenous Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Anesthetics, Local Phase 3
14 Adjuvants, Anesthesia Phase 3
15 Liver Extracts Phase 3
16 Central Nervous System Depressants Phase 3
17 Anesthetics, General Phase 3
18 Anti-Infective Agents Phase 3
19 Anti-Bacterial Agents Phase 3
20 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery Recruiting NCT03214510 Phase 3 Bupivacaine;Fentanyl;Hydromorphone Hydrochloride;Liposomal Bupivacaine
2 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
3 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
4 Maintaining a Prone Position After Use of an Epidural Blood Patch for the Treatment of Post-dural Puncture Headache Terminated NCT02427009 Not Applicable

Search NIH Clinical Center for Epidural Abscess

Cochrane evidence based reviews: epidural abscess

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Genetic Tests for Epidural Abscess

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Anatomical Context for Epidural Abscess

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MalaCards organs/tissues related to Epidural Abscess:

42
Spinal Cord, Brain, Bone, Liver, Prostate, Skin, Kidney
Sources

Publications for Epidural Abscess

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Articles related to Epidural Abscess:

(show top 50) (show all 964)
# Title Authors Year
1
Froin's Syndrome Mimicking Guillain-Barre Syndrome in a Patient with Spinal Epidural Abscess. ( 30937072 )
2019
2
Unusual presentation of spinal epidural abscess and a cautionary tale of acupuncture. ( 30973862 )
2019
3
Pediatric cervical epidural abscess in a 4-year-old patient: a case-based update. ( 30980128 )
2019
4
Upper Cervical Epidural Abscess Resulting in Respiratory Compromise After Lumbar Steroid Injection. ( 31003824 )
2019
5
A Unique Presentation of a Large, Seven-segment, Spinal Epidural Abscess in a Patient with a Pleural Empyema. ( 31019862 )
2019
6
Update on spinal epidural abscess. ( 31021957 )
2019
7
Development of a machine learning algorithm for prediction of failure of non-operative management in spinal epidural abscess. ( 31059819 )
2019
8
Spinal Epidural Abscess in Melioidosis: A Rare Case Report from Eastern India. ( 31106087 )
2019
9
Epidural Abscess During a Spinal Cord Stimulator Trial: A Case Report. ( 29516616 )
2019
10
Timing of surgical interventions for upper cervical epidural abscess: a case report and review of the literature. ( 30915554 )
2019
11
Treatment of a Staphylococcus lugdunensis cervical epidural abscess. ( 30898958 )
2019
12
Shiny Foreign Body in the Frontal Sinus Causing Epidural Abscess. ( 30841725 )
2019
13
MRSA Spinal Epidural Abscess as a Neurosurgical and Infectious Disease Emergency with Unresolved Antimicrobial Solution. ( 30838147 )
2019
14
Spinal Epidural Abscess in Children: Case Report and Review of the Literature. ( 30797918 )
2019
15
Infratentorial Epidural Abscess Secondary to Furunculosis: Case Report and a Review of the Literature. ( 30765993 )
2019
16
Neutrophil to Lymphocyte Ratio and Mortality in Spinal Epidural Abscess. ( 30763714 )
2019
17
Acupuncture-Induced Cranial Epidural Abscess: Case Report and Review of the Literature. ( 30743042 )
2019
18
Challenges in diagnosis of spinal epidural abscess: A case report. ( 30702572 )
2019
19
Livestock-associated methicillin-resistant Staphylococcus aureus (clonal complex 398) causing bacteremia and epidural abscess. ( 30641203 )
2019
20
A case of extensive epidural abscess concomitant with intracranial involvement due to Staphylococcus aureus successfully treated with ceftriaxone in combination with linezolid and rifampin. ( 30511025 )
2019
21
A Classification System for Spinal Cord Compression and its Association With Neurological Deficit in Spinal Epidural Abscess. ( 30451783 )
2019
22
30-day Mortality Following Surgery for Spinal Epidural Abscess: Incidence, Risk Factors, Predictive Algorithm, and Associated Complications. ( 30234819 )
2019
23
Fungal spinal epidural abscess: a case series of nine patients. ( 30121322 )
2019
24
First case of cervical epidural abscess caused by brucellosis in Saudi Arabia: A case report and literature review. ( 29682450 )
2018
25
Vertebral Osteomyelitis, Discitis, and Epidural Abscess: A Rare Complication of Cardiobacterium Endocarditis. ( 30397618 )
2018
26
Successful Conservative Management of Delayed Cervical Spondylodiscitis with Epidural Abscess Caused by Esophageal Diverticulitis: A Case Report and Review of Literature. ( 29883818 )
2018
27
Man-in-the-barrel syndrome: Case report of ventral epidural abscess and review of the literature. ( 29416905 )
2018
28
Spinal cord compression secondary to epidural abscess: the importance of prompt diagnosis and management. ( 29437718 )
2018
29
Postoperative epidural abscess after spinal anaesthesia for a circumcision necessitated by phimosis. ( 29477995 )
2018
30
Clinical outcomes of percutaneous suction aspiration and drainage for the treatment of infective spondylodiscitis with paravertebral or epidural abscess. ( 29496623 )
2018
31
Tuberculous lumbar spinal epidural abscess in a young adult (case report). ( 29521260 )
2018
32
Aspergillus spinal epidural abscess: case presentation and review of the literature. ( 29531797 )
2018
33
Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. ( 29534714 )
2018
34
A Predictive Model Facilitates Early Recognition of Spinal Epidural Abscess in Adults. ( 29560054 )
2018
35
Nonoperative Management of Spinal Epidural Abscess: Development of a Predictive Algorithm for Failure. ( 29613923 )
2018
36
Lumbar Gout Tophus Mimicking Epidural Abscess with Magnetic Resonance Imaging, Bone, and Gallium Scans. ( 29643682 )
2018
37
Independent predictors of spinal epidural abscess recurrence. ( 29649612 )
2018
38
Simultaneous occurrence of spinal epidural abscess and disk herniation causing irreversible neurologic deficits: A case report and review of the literature. ( 29721126 )
2018
39
Epidural abscess presenting as severe depression with suicidal ideations: Case report. ( 29740504 )
2018
40
Spinal Epidural Abscess in an Infant Presenting as Fever and Respiratory Distress. ( 29757891 )
2018
41
The Prognostic Accuracy of Suggested Predictors of Failure of Medical Management in Patients With Nontuberculous Spinal Epidural Abscess. ( 29796377 )
2018
42
Septic arthritis of the temporomandibular joint leading to an epidural abscess. ( 29895543 )
2018
43
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-Schönlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
44
Post Dengue Fever Epidural abscess with or without Spondylodiscitis-a Case series of 8 patients in a single season in a single Centre: Do the dengue has a predilection for the Neural tissue? ( 29979359 )
2018
45
Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review. ( 30073138 )
2018
46
Diagnostic Quandary: Salmonella Agbeni Vertebral Osteomyelitis and Epidural Abscess. ( 30327739 )
2018
47
Neurobrucellosis complicated with lumbar epidural abscess; A shepherd’s agony ( 30669216 )
2018
48
Antibiotic-Resistant Spondylodiscitis With Canal Invasion and Aggressive Evolution to Epidural Abscess: A Case Series of Spontaneous Occurrence in 16 Patients. ( 30619679 )
2018
49
Etiology and Surgical Management of Cervical Spinal Epidural Abscess (SEA):: A Systematic Review. ( 30574440 )
2018
50
Nocardial spinal epidural abscess with lumbar disc herniation: A case report and review of literature. ( 30544463 )
2018
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Variations for Epidural Abscess

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Expression for Epidural Abscess

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Search GEO for disease gene expression data for Epidural Abscess.
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Pathways for Epidural Abscess

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GO Terms for Epidural Abscess

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Molecular functions related to Epidural Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 CD6 CRP MRI1
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Sources for Epidural Abscess

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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