MCID: EPD005
MIFTS: 36

Epidural Abscess

Categories: Neuronal diseases

Aliases & Classifications for Epidural Abscess

MalaCards integrated aliases for Epidural Abscess:

Name: Epidural Abscess 12 44 15 73
Abscess Epidural 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11387
MeSH 44 D020802
SNOMED-CT 68 61974008
UMLS 73 C0270629

Summaries for Epidural Abscess

Disease Ontology : 12 A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).

MalaCards based summary : Epidural Abscess, also known as abscess epidural, is related to discitis and arachnoiditis. An important gene associated with Epidural Abscess is CRP (C-Reactive Protein). The drugs Linezolid and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 An epidural abscess refers to a collection of pus and infectious material located in the epidural space... more...

Related Diseases for Epidural Abscess

Diseases related to Epidural Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 discitis 32.2 CRP MRI1
2 arachnoiditis 29.2 MNX1 MRI1
3 osteomyelitis 10.6
4 meningitis 10.4
5 arthritis 10.3
6 sinusitis 10.3
7 endocarditis 10.3
8 paraplegia 10.2
9 subdural empyema 10.2
10 brucellosis 10.2
11 pyomyositis 10.2
12 septic arthritis 10.1
13 crohn's disease 10.1
14 quadriplegia 10.1
15 spondylitis 10.1
16 frontal sinusitis 10.1
17 cauda equina syndrome 10.1
18 gout 10.0
19 actinomycosis 10.0
20 bacterial meningitis 10.0
21 rheumatoid arthritis 9.9
22 chronic granulomatous disease 9.9
23 mastoiditis 9.9
24 cat-scratch disease 9.9
25 hyperuricemia 9.9 CRP SLC2A9
26 aortic aneurysm, familial abdominal, 1 9.8
27 sickle cell anemia 9.8
28 dengue virus 9.8
29 dengue disease 9.8
30 diabetes mellitus 9.8
31 leukemia 9.8
32 infective endocarditis 9.8
33 lymphoma 9.8
34 thrombosis 9.8
35 sphenoid sinusitis 9.8
36 myelitis 9.8
37 aortic aneurysm 9.8
38 pancreatitis 9.8
39 pneumonia 9.8
40 sickle cell disease 9.8
41 headache 9.8
42 maturity-onset diabetes of the young 9.8 CRP MNX1
43 bladder cancer 9.7
44 systemic lupus erythematosus 9.7
45 otitis media 9.7
46 parkinson disease, late-onset 9.7
47 pilonidal sinus 9.7
48 pruritic urticarial papules and plaques of pregnancy 9.7
49 temporal arteritis 9.7
50 torticollis 9.7

Graphical network of the top 20 diseases related to Epidural Abscess:



Diseases related to Epidural Abscess

Symptoms & Phenotypes for Epidural Abscess

GenomeRNAi Phenotypes related to Epidural Abscess according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.55 SLC2A9
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.55 MNX1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.55 SLC2A9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.55 SLC2A9
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.55 MNX1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.55 SLC2A9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.55 MNX1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.55 MNX1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.55 SLC2A9
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.55 MNX1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.55 MNX1 MRI1 SLC2A9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.55 SLC2A9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.55 MNX1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.55 MRI1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 SLC2A9

MGI Mouse Phenotypes related to Epidural Abscess:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 8.92 CRP MNX1 SLC2A9 TCF12

Drugs & Therapeutics for Epidural Abscess

Drugs for Epidural Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
2
Vancomycin Approved Phase 3 1404-90-6 14969 441141
3
Cefazolin Approved Phase 3 25953-19-9 656510 33255
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
2 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
3 Maintaining a Prone Position After Use of an Epidural Blood Patch for the Treatment of Post-dural Puncture Headache Terminated NCT02427009 Not Applicable

Search NIH Clinical Center for Epidural Abscess

Cochrane evidence based reviews: epidural abscess

Genetic Tests for Epidural Abscess

Anatomical Context for Epidural Abscess

MalaCards organs/tissues related to Epidural Abscess:

41
Spinal Cord, Brain, Bone, Liver, Colon, Prostate, Skin

Publications for Epidural Abscess

Articles related to Epidural Abscess:

(show top 50) (show all 942)
# Title Authors Year
1
A case of extensive epidural abscess concomitant with intracranial involvement due to Staphylococcus aureus successfully treated with ceftriaxone in combination with linezolid and rifampin. ( 30511025 )
2019
2
First case of cervical epidural abscess caused by brucellosis in Saudi Arabia: A case report and literature review. ( 29682450 )
2018
3
Aspergillus spinal epidural abscess: case presentation and review of the literature. ( 29531797 )
2018
4
Epidural Abscess During a Spinal Cord Stimulator Trial: A Case Report. ( 29516616 )
2018
5
Postoperative epidural abscess after spinal anaesthesia for a circumcision necessitated by phimosis. ( 29477995 )
2018
6
Epidural abscess caused by Schizophyllum commune: A rare case of rhinogenic cranial complication by a filamentous basidiomycete. ( 29125646 )
2018
7
Independent predictors of spinal epidural abscess recurrence. ( 29649612 )
2018
8
Clinical outcomes of percutaneous suction aspiration and drainage for the treatment of infective spondylodiscitis with paravertebral or epidural abscess. ( 29496623 )
2018
9
Successfully Conservative Management of Delayed Cervical Spondylodiscitis with Epidural Abscess Caused by Esophageal Diverticulitis: A Case Report and Review of Literature. ( 29883818 )
2018
10
Spinal cord compression secondary to epidural abscess: the importance of prompt diagnosis and management. ( 29437718 )
2018
11
Simultaneous occurrence of spinal epidural abscess and disk herniation causing irreversible neurologic deficits: A case report and review of the literature. ( 29721126 )
2018
12
Nonoperative Management of Spinal Epidural Abscess: Development of a Predictive Algorithm for Failure. ( 29613923 )
2018
13
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
14
Man-in-the-barrel syndrome: Case report of ventral epidural abscess and review of the literature. ( 29416905 )
2018
15
Post Dengue Fever Epidural abscess with or without Spondylodiscitis-a Case series of 8 patients in a single season in a single Centre: Do the dengue has a predilection for the Neural tissue? ( 29979359 )
2018
16
The Prognostic Accuracy of Suggested Predictors of Failure of Medical Management in Patients With Nontuberculous Spinal Epidural Abscess. ( 29796377 )
2018
17
Lumbar Gout Tophus Mimicking Epidural Abscess with Magnetic Resonance Imaging, Bone, and Gallium Scans. ( 29643682 )
2018
18
Septic arthritis of the temporomandibular joint leading to an epidural abscess. ( 29895543 )
2018
19
A Predictive Model Facilitates Early Recognition of Spinal Epidural Abscess in Adults. ( 29560054 )
2018
20
Tuberculous lumbar spinal epidural abscess in a young adult (case report). ( 29521260 )
2018
21
Development of Predictive Algorithms for Pre-Treatment Motor Deficit and 90-Day Mortality in Spinal Epidural Abscess. ( 29916930 )
2018
22
Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. ( 29534714 )
2018
23
Epidural Abscess: A Propensity Analysis of Surgical Treatment Strategies. ( 29916954 )
2018
24
Spinal Epidural Abscess in an Infant Presenting as Fever and Respiratory Distress. ( 29757891 )
2018
25
Vertebral Osteomyelitis, Discitis, and Epidural Abscess: A Rare Complication of Cardiobacterium Endocarditis. ( 30397618 )
2018
26
Epidural abscess presenting as severe depression with suicidal ideations: Case report. ( 29740504 )
2018
27
Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review. ( 30073138 )
2018
28
Fungal spinal epidural abscess: a case series of nine patients. ( 30121322 )
2018
29
Spinal epidural abscess caused by a community acquired extended spectrum beta lactamase producing Klebsiella pneumonia. ( 30128293 )
2018
30
Spinal epidural abscess caused by Gardnerella vaginalis and Prevotella amnii. ( 30140147 )
2018
31
Spinal Tophi Causing Cord Compression and Mimicking Epidural Abscess in a Young Man With Lesch-Nyhan Variant. ( 30222628 )
2018
32
30-Day Mortality Following Surgery for Spinal Epidural Abscess: Incidence, Risk Factors, Predictive Algorithm, and Associated Complications. ( 30234819 )
2018
33
Brain and Spinal Epidural Abscess. ( 30273242 )
2018
34
Diagnostic Quandary: Salmonella Agbeni Vertebral Osteomyelitis and Epidural Abscess. ( 30327739 )
2018
35
Physician and patients factors associated with outcome of spinal epidural abscess related malpractice litigation. ( 30370036 )
2018
36
A Classification System for Spinal Cord Compression and its Association With Neurological Deficit in Spinal Epidural Abscess. ( 30451783 )
2018
37
Spinal-epidural Abscess Presenting as an Acute Abdomen in a Child: A Case Report and Review of the Literature. ( 30459907 )
2018
38
Albumin and Spinal Epidural Abscess: Derivation and Validation in Two Independent Datasets. ( 30500590 )
2018
39
Post Dengue Fever Epidural Abscess With or Without Spondylodiscitis: A Case Series of Eight Patients in a Single Season in a Single Center: Does the Dengue Have a Predilection for the Neural Tissue? ( 30507729 )
2018
40
Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression. ( 30537555 )
2018
41
Nocardial spinal epidural abscess with lumbar disc herniation: A case report and review of literature. ( 30544463 )
2018
42
The time-sensitive challenge of diagnosing spinal epidural abscess in the emergency department. ( 28779448 )
2017
43
Delayed Brain Edema and Swelling following Craniectomy for Evacuation of an Epidural Abscess that Improved by Cranioplasty: Case Report. ( 28852606 )
2017
44
Cervical epidural analgesia complicated by epidural abscess: A case report and literature review. ( 28984753 )
2017
45
Holospinal epidural abscess combined with multifocal extraspinal abscesses in an elderly patient with rheumatoid arthritis receiving infliximab therapy. ( 29115101 )
2017
46
A spinal epidural abscess due to Streptobacillus moniliformis infection following a rat bite: case report. ( 28430048 )
2017
47
A Pott's Puffy Tumor Associated with Epidural - Cutaneous Fistula and Epidural Abscess: Case Report. ( 28443599 )
2017
48
Epidural Metastasis in Malignant Thymoma Mimicking Epidural Abscess: Case Report and Literature Review. ( 29301178 )
2017
49
Cervical spine epidural abscess: a single center analytical comparison to the literature. ( 28690871 )
2017
50
A Case of Infective Endocarditis and Spinal Epidural Abscess Caused by<i>Streptococcus mitis</i>Bacteremia. ( 29038738 )
2017

Variations for Epidural Abscess

Expression for Epidural Abscess

Search GEO for disease gene expression data for Epidural Abscess.

Pathways for Epidural Abscess

GO Terms for Epidural Abscess

Sources for Epidural Abscess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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