MCID: EPD005
MIFTS: 34

Epidural Abscess

Categories: Neuronal diseases

Aliases & Classifications for Epidural Abscess

MalaCards integrated aliases for Epidural Abscess:

Name: Epidural Abscess 12 45 15 17 74
Abscess Epidural 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11387
MeSH 45 D020802
SNOMED-CT 69 61974008
UMLS 74 C0270629

Summaries for Epidural Abscess

Disease Ontology : 12 A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).

MalaCards based summary : Epidural Abscess, also known as abscess epidural, is related to discitis and osteomyelitis. An important gene associated with Epidural Abscess is CRP (C-Reactive Protein). The drugs Vancomycin and Linezolid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 An epidural abscess refers to a collection of pus and infectious material located in the epidural space... more...

Related Diseases for Epidural Abscess

Diseases related to Epidural Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 discitis 32.3 CRP MRI1
2 osteomyelitis 10.7
3 meningitis 10.4
4 arthritis 10.3
5 sinusitis 10.3
6 endocarditis 10.3
7 paraplegia 10.2
8 subdural empyema 10.2
9 brucellosis 10.2
10 pyomyositis 10.2
11 septic arthritis 10.2
12 spondylitis 10.1
13 crohn's disease 10.1
14 frontal sinusitis 10.1
15 cauda equina syndrome 10.1
16 quadriplegia 10.1
17 gout 10.0
18 actinomycosis 10.0
19 bacterial meningitis 10.0
20 aortic aneurysm, familial abdominal, 1 9.9
21 rheumatoid arthritis 9.9
22 chronic granulomatous disease 9.9
23 mastoiditis 9.9
24 cat-scratch disease 9.9
25 aortic aneurysm 9.9
26 sickle cell anemia 9.9
27 dengue virus 9.9
28 dengue disease 9.9
29 diabetes mellitus 9.9
30 leukemia 9.9
31 infective endocarditis 9.9
32 lymphoma 9.9
33 thrombosis 9.9
34 sphenoid sinusitis 9.9
35 myelitis 9.9
36 pleural empyema 9.9
37 pancreatitis 9.9
38 pneumonia 9.9
39 sickle cell disease 9.9
40 headache 9.9
41 bladder cancer 9.7
42 systemic lupus erythematosus 9.7
43 otitis media 9.7
44 parkinson disease, late-onset 9.7
45 pilonidal sinus 9.7
46 pruritic urticarial papules and plaques of pregnancy 9.7
47 torticollis 9.7
48 psoriatic arthritis 9.7
49 hepatitis c virus 9.7
50 ewing sarcoma 9.7

Graphical network of the top 20 diseases related to Epidural Abscess:



Diseases related to Epidural Abscess

Symptoms & Phenotypes for Epidural Abscess

GenomeRNAi Phenotypes related to Epidural Abscess according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.36 SLC2A9
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.36 SLC2A9
3 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 SLC2A9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.36 SLC2A9
5 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.36 SLC2A9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 SLC2A9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.36 MRI1 SLC2A9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.36 SLC2A9
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.36 MRI1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.36 SLC2A9

Drugs & Therapeutics for Epidural Abscess

Drugs for Epidural Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 3 1404-90-6 441141 14969
2
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
3
Cefazolin Approved Phase 3 25953-19-9 656510 33255
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
2 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
3 Maintaining a Prone Position After Use of an Epidural Blood Patch for the Treatment of Post-dural Puncture Headache Terminated NCT02427009 Not Applicable

Search NIH Clinical Center for Epidural Abscess

Cochrane evidence based reviews: epidural abscess

Genetic Tests for Epidural Abscess

Anatomical Context for Epidural Abscess

MalaCards organs/tissues related to Epidural Abscess:

42
Spinal Cord, Brain, Bone, Liver, Prostate, Skin, Kidney

Publications for Epidural Abscess

Articles related to Epidural Abscess:

(show top 50) (show all 957)
# Title Authors Year
1
A case of extensive epidural abscess concomitant with intracranial involvement due to Staphylococcus aureus successfully treated with ceftriaxone in combination with linezolid and rifampin. ( 30511025 )
2019
2
Livestock-associated methicillin-resistant Staphylococcus aureus (clonal complex 398) causing bacteremia and epidural abscess. ( 30641203 )
2019
3
Challenges in diagnosis of spinal epidural abscess: A case report. ( 30702572 )
2019
4
Acupuncture induced cranial epidural abscess: Case report and review of the literature. ( 30743042 )
2019
5
Neutrophil to Lymphocyte Ratio and Mortality in Spinal Epidural Abscess. ( 30763714 )
2019
6
Infratentorial Epidural Abscess Secondary to Furunculosis: Case Report and a Review of the Literature. ( 30765993 )
2019
7
Spinal Epidural Abscess in Children: Case Report and Review of the Literature. ( 30797918 )
2019
8
MRSA Spinal Epidural Abscess as a Neurosurgical and Infectious Disease Emergency with Unresolved Antimicrobial Solution. ( 30838147 )
2019
9
Shiny Foreign Body in the Frontal Sinus Causing Epidural Abscess. ( 30841725 )
2019
10
Treatment of a Staphylococcus lugdunensis cervical epidural abscess. ( 30898958 )
2019
11
Timing of surgical interventions for upper cervical epidural abscess: a case report and review of the literature. ( 30915554 )
2019
12
First case of cervical epidural abscess caused by brucellosis in Saudi Arabia: A case report and literature review. ( 29682450 )
2018
13
Aspergillus spinal epidural abscess: case presentation and review of the literature. ( 29531797 )
2018
14
Epidural Abscess During a Spinal Cord Stimulator Trial: A Case Report. ( 29516616 )
2018
15
Postoperative epidural abscess after spinal anaesthesia for a circumcision necessitated by phimosis. ( 29477995 )
2018
16
Epidural abscess caused by Schizophyllum commune: A rare case of rhinogenic cranial complication by a filamentous basidiomycete. ( 29125646 )
2018
17
Independent predictors of spinal epidural abscess recurrence. ( 29649612 )
2018
18
Clinical outcomes of percutaneous suction aspiration and drainage for the treatment of infective spondylodiscitis with paravertebral or epidural abscess. ( 29496623 )
2018
19
Successfully Conservative Management of Delayed Cervical Spondylodiscitis with Epidural Abscess Caused by Esophageal Diverticulitis: A Case Report and Review of Literature. ( 29883818 )
2018
20
Spinal cord compression secondary to epidural abscess: the importance of prompt diagnosis and management. ( 29437718 )
2018
21
Simultaneous occurrence of spinal epidural abscess and disk herniation causing irreversible neurologic deficits: A case report and review of the literature. ( 29721126 )
2018
22
Nonoperative Management of Spinal Epidural Abscess: Development of a Predictive Algorithm for Failure. ( 29613923 )
2018
23
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
24
Man-in-the-barrel syndrome: Case report of ventral epidural abscess and review of the literature. ( 29416905 )
2018
25
Post Dengue Fever Epidural abscess with or without Spondylodiscitis-a Case series of 8 patients in a single season in a single Centre: Do the dengue has a predilection for the Neural tissue? ( 29979359 )
2018
26
The Prognostic Accuracy of Suggested Predictors of Failure of Medical Management in Patients With Nontuberculous Spinal Epidural Abscess. ( 29796377 )
2018
27
Lumbar Gout Tophus Mimicking Epidural Abscess with Magnetic Resonance Imaging, Bone, and Gallium Scans. ( 29643682 )
2018
28
Septic arthritis of the temporomandibular joint leading to an epidural abscess. ( 29895543 )
2018
29
A Predictive Model Facilitates Early Recognition of Spinal Epidural Abscess in Adults. ( 29560054 )
2018
30
Tuberculous lumbar spinal epidural abscess in a young adult (case report). ( 29521260 )
2018
31
Development of Predictive Algorithms for Pre-Treatment Motor Deficit and 90-Day Mortality in Spinal Epidural Abscess. ( 29916930 )
2018
32
Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. ( 29534714 )
2018
33
Epidural Abscess: A Propensity Analysis of Surgical Treatment Strategies. ( 29916954 )
2018
34
Spinal Epidural Abscess in an Infant Presenting as Fever and Respiratory Distress. ( 29757891 )
2018
35
Epidural abscess presenting as severe depression with suicidal ideations: Case report. ( 29740504 )
2018
36
Spinal epidural abscess associated with an epidural catheter in a woman with complex regional pain syndrome and selective IgG3 deficiency: A case report. ( 30557971 )
2018
37
Vertebral Osteomyelitis, Discitis, and Epidural Abscess: A Rare Complication of Cardiobacterium Endocarditis. ( 30397618 )
2018
38
Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review. ( 30073138 )
2018
39
Fungal spinal epidural abscess: a case series of nine patients. ( 30121322 )
2018
40
Spinal epidural abscess caused by a community acquired extended spectrum beta lactamase producing Klebsiella pneumonia. ( 30128293 )
2018
41
Spinal epidural abscess caused by Gardnerella vaginalis and Prevotella amnii. ( 30140147 )
2018
42
Spinal Tophi Causing Cord Compression and Mimicking Epidural Abscess in a Young Man With Lesch-Nyhan Variant. ( 30222628 )
2018
43
30-Day Mortality Following Surgery for Spinal Epidural Abscess: Incidence, Risk Factors, Predictive Algorithm, and Associated Complications. ( 30234819 )
2018
44
Brain and Spinal Epidural Abscess. ( 30273242 )
2018
45
Diagnostic Quandary: Salmonella Agbeni Vertebral Osteomyelitis and Epidural Abscess. ( 30327739 )
2018
46
Physician and patients factors associated with outcome of spinal epidural abscess related malpractice litigation. ( 30370036 )
2018
47
A Classification System for Spinal Cord Compression and its Association With Neurological Deficit in Spinal Epidural Abscess. ( 30451783 )
2018
48
Spinal-epidural Abscess Presenting as an Acute Abdomen in a Child: A Case Report and Review of the Literature. ( 30459907 )
2018
49
Albumin and Spinal Epidural Abscess: Derivation and Validation in Two Independent Datasets. ( 30500590 )
2018
50
Post Dengue Fever Epidural Abscess With or Without Spondylodiscitis: A Case Series of Eight Patients in a Single Season in a Single Center: Does the Dengue Have a Predilection for the Neural Tissue? ( 30507729 )
2018

Variations for Epidural Abscess

Expression for Epidural Abscess

Search GEO for disease gene expression data for Epidural Abscess.

Pathways for Epidural Abscess

GO Terms for Epidural Abscess

Molecular functions related to Epidural Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 CD6 CRP MRI1

Sources for Epidural Abscess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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