MCID: EPD019
MIFTS: 33

Epidural Neoplasm

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Epidural Neoplasm

MalaCards integrated aliases for Epidural Neoplasm:

Name: Epidural Neoplasm 12 15
Epidural Neoplasms 44 73
Extradural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3618
MeSH 44 D015174
NCIt 50 C3019
UMLS 73 C0014536

Summaries for Epidural Neoplasm

MalaCards based summary : Epidural Neoplasm, also known as epidural neoplasms, is related to spinal cancer and vulvar sarcoma. An important gene associated with Epidural Neoplasm is PTCHD3 (Patched Domain Containing 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and bone, and related phenotypes are Reduced mammosphere formation and Increased proliferation

Related Diseases for Epidural Neoplasm

Diseases related to Epidural Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 spinal cancer 11.0
2 vulvar sarcoma 10.8 PTPRC SMARCB1
3 breast lymphoma 10.8 BCL6 CD5
4 heart lymphoma 10.8 BCL6 PTPRC
5 intravascular large b-cell lymphoma 10.8 BCL6 CD5
6 nodular lymphocyte predominant hodgkin lymphoma 10.7 BCL6 PTPRC
7 composite lymphoma 10.7 BCL6 CD5
8 testicular lymphoma 10.7 BCL6 PTPRC
9 malignant spiradenoma 10.7 KRT5 TP53
10 vulvar intraepithelial neoplasia 10.7 KRT5 TP53
11 cerebral ventricle cancer 10.7 SMARCB1 TP53
12 keratinizing squamous cell carcinoma 10.7 KRT5 TP53
13 cerebrum cancer 10.7 SMARCB1 TP53
14 supratentorial cancer 10.7 SMARCB1 TP53
15 breast squamous cell carcinoma 10.6 KRT5 TP53
16 schneiderian carcinoma 10.6 KRT5 TP53
17 thymic epithelial tumor 10.6 CD5 CD99
18 b cell prolymphocytic leukemia 10.6 CD5 TP53
19 cll/sll 10.5 CD5 TP53
20 pleomorphic xanthoastrocytoma 10.5 SMARCB1 TP53
21 cloacogenic carcinoma 10.5 CD27 KRT5 PTPRC
22 oropharynx cancer 10.5 CD6 TP53
23 lymphosarcoma 10.5 BCL6 PTPRC
24 breast adenomyoepithelioma 10.5 CD99 KRT5
25 t-cell/histiocyte rich large b cell lymphoma 10.5 BCL6 TNFRSF8
26 breast myoepithelial neoplasm 10.4 CD99 KRT5
27 plasmablastic lymphoma 10.4 BCL6 PTPRC
28 conventional fibrosarcoma 10.4 PTPRC TNFRSF8
29 malignant biphasic mesothelioma 10.4 FUT4 KRT5
30 adult lymphoma 10.4 CD5 TNFRSF8
31 necrotizing sialometaplasia 10.4 CD5 KRT5 TP53
32 sarcomatoid squamous cell skin carcinoma 10.4 KRT5 PTPRC TP53
33 marek disease 10.4 TNFRSF8 TP53
34 prostate squamous cell carcinoma 10.4 KRT5 TP53
35 predominantly cortical thymoma 10.3 KRT19 PTPRC
36 reticulum cell sarcoma 10.3 PTPRC TNFRSF8
37 mature b-cell neoplasm 10.3 BCL6 PTPRC TP53
38 extraskeletal ewing sarcoma 10.3 CD99 PTPRC
39 kidney rhabdoid cancer 10.3 CD99 PTPRC SMARCB1
40 odontoma 10.3 KRT19 KRT5
41 gastric lymphoma 10.3 BCL6 TP53
42 mantle cell lymphoma 10.3 BCL6 CD5 TP53
43 bladder carcinoma in situ 10.2 KRT19 TP53
44 sternum cancer 10.2 FUT4 TNFRSF8
45 connective tissue cancer 10.2 CD99 SMARCB1 TP53
46 cervical clear cell adenocarcinoma 10.2 KRT19 KRT5
47 nervous system cancer 10.2 CD99 SMARCB1 TP53
48 small cell sarcoma 10.2 SMARCB1 TP53
49 pigmented villonodular synovitis 10.2 PTPRC TP53
50 lung lymphoma 10.2 BCL6 CD5 TNFRSF8

Graphical network of the top 20 diseases related to Epidural Neoplasm:



Diseases related to Epidural Neoplasm

Symptoms & Phenotypes for Epidural Neoplasm

GenomeRNAi Phenotypes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 BCL6 CD27 CD5 CD6 PTPRC SMARCB1
2 Increased proliferation GR00094-A 8.96 SMARCB1 TP53

MGI Mouse Phenotypes related to Epidural Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 PTPRC SMARCB1 TNFRSF8 TP53 ANKRD11 BCL6
2 immune system MP:0005387 9.7 FUT4 PTPRC SMARCB1 TNFRSF8 TP53 ANKRD11
3 no phenotypic analysis MP:0003012 9.1 KRT19 KRT5 PTPRC TP53 BCL6 CD5

Drugs & Therapeutics for Epidural Neoplasm

Drugs for Epidural Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2
Menthol Approved Phase 1 2216-51-5 16666
3 Alkylating Agents Phase 1
4 Anesthetics Phase 1
5 Antineoplastic Agents, Alkylating Phase 1
6 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
2 Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery Unknown status NCT02527304 Not Applicable
3 Optimal Timing of Postoperative Magnetic Resonance Imaging (MRI) in Patients With Extradural Spinal Recruiting NCT02790294 Not Applicable

Search NIH Clinical Center for Epidural Neoplasm

Cochrane evidence based reviews: epidural neoplasms

Genetic Tests for Epidural Neoplasm

Anatomical Context for Epidural Neoplasm

MalaCards organs/tissues related to Epidural Neoplasm:

41
Spinal Cord, Bone

Publications for Epidural Neoplasm

Articles related to Epidural Neoplasm:

# Title Authors Year
1
Plain film clues to the diagnosis of spinal epidural neoplasm and infection. ( 8492898 )
1993
2
Evaluation of back pain caused by epidural neoplasm. ( 24573025 )
1993
3
Identification of epidural neoplasm. Radiography and bone scintigraphy in the symptomatic and asymptomatic spine. ( 2804911 )
1989
4
[Cortical somatosensory evoked potential associated with experimental chronic cord compression by epidural neoplasm in rabbits]. ( 3768192 )
1986
5
Circulatory disturbance of the spinal cord with epidural neoplasm in rats. ( 3926963 )
1985
6
Disturbance of the circulation in the spinal cord with epidural neoplasm. ( 4069060 )
1985
7
Experimental spinal cord compression by epidural neoplasm. ( 558545 )
1977

Variations for Epidural Neoplasm

Expression for Epidural Neoplasm

Search GEO for disease gene expression data for Epidural Neoplasm.

Pathways for Epidural Neoplasm

Pathways related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 CD6 CD99 PTPRC
2 10.75 BCL6 CD27 CD5 PTPRC TNFRSF8

GO Terms for Epidural Neoplasm

Cellular components related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 BCL6 TP53

Biological processes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.62 BCL6 SMARCB1 TNFRSF8 TP53
2 inflammatory response GO:0006954 9.56 BCL6 CD27 CD6 TNFRSF8
3 regulation of apoptotic process GO:0042981 9.46 BCL6 CD27 TNFRSF8 TP53
4 positive regulation of histone deacetylation GO:0031065 8.96 BCL6 TP53
5 apoptotic signaling pathway GO:0097190 8.8 CD27 CD5 TNFRSF8

Molecular functions related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 CD27 TNFRSF8

Sources for Epidural Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....