MCID: EPD019
MIFTS: 30

Epidural Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Epidural Neoplasm

MalaCards integrated aliases for Epidural Neoplasm:

Name: Epidural Neoplasm 12 15
Epidural Neoplasms 44 73
Extradural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3618
MeSH 44 D015174
NCIt 50 C3019
UMLS 73 C0014536

Summaries for Epidural Neoplasm

MalaCards based summary : Epidural Neoplasm, also known as epidural neoplasms, is related to spinal cancer and vulvar sarcoma. An important gene associated with Epidural Neoplasm is PTCHD3 (Patched Domain Containing 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Melphalan and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and colon, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Epidural Neoplasm

Diseases related to Epidural Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 spinal cancer 11.2
2 vulvar sarcoma 10.2 PTPRC SMARCB1
3 breast lymphoma 10.2 BCL6 CD5
4 intravascular large b-cell lymphoma 10.2 BCL6 CD5
5 lymphoepithelioma-like thymic carcinoma 10.2 CD5 KRT5
6 heart lymphoma 10.2 BCL6 PTPRC
7 composite lymphoma 10.2 BCL6 CD5
8 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 BCL6 PTPRC
9 testicular lymphoma 10.2 BCL6 PTPRC
10 autoimmune lymphoproliferative syndrome, type v 10.2 BCL6 CD5
11 plasmablastic lymphoma 10.2 BCL6 PTPRC
12 thymic epithelial tumor 10.2 CD5 CD99
13 necrotizing sialometaplasia 10.2 CD5 KRT5
14 cd45 deficiency 10.2 CD5 PTPRC
15 nasal cavity squamous cell carcinoma 10.2 ANKRD11 KRT5
16 anus cancer 10.2 CD6 KRT5
17 breast adenomyoepithelioma 10.2 CD99 KRT5
18 breast myoepithelial neoplasm 10.2 CD99 KRT5
19 malignant biphasic mesothelioma 10.1 FUT4 KRT5
20 fibrosarcomatous osteosarcoma 10.1 FUT4 KRT5
21 cloacogenic carcinoma 10.1 CD27 KRT5 PTPRC
22 extraskeletal ewing sarcoma 10.1 CD99 PTPRC
23 gamma heavy chain disease 10.1 FUT4 PTPRC
24 lymphosarcoma 10.1 BCL6 CD5 PTPRC
25 lymphoma, hodgkin, classic 10.1 BCL6 CD5 PTPRC
26 cervical clear cell adenocarcinoma 10.1 KRT19 KRT5
27 odontoma 10.1 KRT19 KRT5
28 predominantly cortical thymoma 10.1 KRT19 PTPRC
29 photokeratitis 10.1 DNTT PTPRC
30 mantle cell lymphoma 10.1 BCL6 CD5 PTPRC
31 kidney rhabdoid cancer 10.1 CD99 PTPRC SMARCB1
32 bone ewing's sarcoma 10.1 CD99 PTPRC
33 lipoadenoma 10.1 KRT19 KRT5
34 dendritic cell tumor 10.1 DNTT PTPRC
35 pregnancy adenoma 10.1 KRT19 KRT5
36 thymus cancer 10.0 CD5 DNTT KRT5
37 anterior scleritis 10.0 CD5 KRT19
38 t-cell/histiocyte rich large b cell lymphoma 10.0 BCL6 TNFRSF8
39 myeloid sarcoma 10.0 DNTT PTPRC
40 thymoma 10.0 CD5 DNTT PTPRC
41 conventional fibrosarcoma 10.0 PTPRC TNFRSF8
42 mucinous tubular and spindle renal cell carcinoma 10.0 FUT4 KRT19
43 reticulum cell sarcoma 10.0 PTPRC TNFRSF8
44 intraneural perineurioma 10.0 KRT19 KRT5
45 oropharynx cancer 10.0 CD6 KRT5
46 adult lymphoma 10.0 CD5 TNFRSF8
47 pericardium cancer 10.0 CD99 KRT19
48 sternum cancer 10.0 FUT4 TNFRSF8
49 lung lymphoma 9.9 BCL6 CD5 TNFRSF8
50 peripheral t-cell lymphoma 9.9 BCL6 CD5 TNFRSF8

Graphical network of the top 20 diseases related to Epidural Neoplasm:



Diseases related to Epidural Neoplasm

Symptoms & Phenotypes for Epidural Neoplasm

GenomeRNAi Phenotypes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 BCL6 CD27 CD5 CD6 PTPRC SMARCB1

MGI Mouse Phenotypes related to Epidural Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 ANKRD11 BCL6 CD27 CD5 CD6 DNTT
2 immune system MP:0005387 9.32 ANKRD11 BCL6 CD27 CD5 CD6 DNTT

Drugs & Therapeutics for Epidural Neoplasm

Drugs for Epidural Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2 Alkylating Agents Phase 1
3 Immunosuppressive Agents Phase 1
4 Anesthetics Phase 1
5 Immunologic Factors Phase 1
6 Antineoplastic Agents, Alkylating Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intra-arterial Chemotherapy for Spinal Metastases Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
2 Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery Unknown status NCT02527304 Not Applicable
3 Optimal Timing of Postoperative Magnetic Resonance Imaging (MRI) in Patients With Extradural Spinal Recruiting NCT02790294 Not Applicable

Search NIH Clinical Center for Epidural Neoplasm

Cochrane evidence based reviews: epidural neoplasms

Genetic Tests for Epidural Neoplasm

Anatomical Context for Epidural Neoplasm

MalaCards organs/tissues related to Epidural Neoplasm:

41
Bone, Kidney, Colon, Heart, Breast, B Cells, Thymus

Publications for Epidural Neoplasm

Articles related to Epidural Neoplasm:

# Title Authors Year
1
Plain film clues to the diagnosis of spinal epidural neoplasm and infection. ( 8492898 )
1993
2
Evaluation of back pain caused by epidural neoplasm. ( 24573025 )
1993
3
Identification of epidural neoplasm. Radiography and bone scintigraphy in the symptomatic and asymptomatic spine. ( 2804911 )
1989
4
[Cortical somatosensory evoked potential associated with experimental chronic cord compression by epidural neoplasm in rabbits]. ( 3768192 )
1986
5
Circulatory disturbance of the spinal cord with epidural neoplasm in rats. ( 3926963 )
1985
6
Disturbance of the circulation in the spinal cord with epidural neoplasm. ( 4069060 )
1985
7
Surgical treatment of vertebro-epidural neoplasms of the cervical tract via the anterior approach. ( 6527146 )
1984
8
Edema and circulatory disturbance in the spinal cord compressed by epidural neoplasms in rabbits. ( 7351559 )
1980
9
Experimental spinal cord compression by epidural neoplasm. ( 558545 )
1977
10
Myelopathy caused by metastatic spinal epidural neoplasms. ( 4162986 )
1967

Variations for Epidural Neoplasm

Expression for Epidural Neoplasm

Search GEO for disease gene expression data for Epidural Neoplasm.

Pathways for Epidural Neoplasm

Pathways related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 CD6 CD99 PTPRC
2 10.75 BCL6 CD27 CD5 PTPRC TNFRSF8
3 10.63 CD27 TNFRSF8

GO Terms for Epidural Neoplasm

Cellular components related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CD27 CD5 CD6 PTPRC
2 cell periphery GO:0071944 8.8 FUT4 KRT19 PTPRC

Biological processes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell differentiation GO:0045582 8.62 CD27 PTPRC

Sources for Epidural Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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