Epiglottis Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Epiglottis Cancer

MalaCards integrated aliases for Epiglottis Cancer:

Name: Epiglottis Cancer ¹² ¹⁵

Malignant Tumor of Epiglottis ¹²

Epiglottic Cancer ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of oropharynx

Malignant neoplasm: Anterior surface of epiglottis

External Ids:

Disease Ontology ¹² DOID:8133

ICD9CM ³⁴ 146.4

NCIt ⁴⁹ C35697 C4836

SNOMED-CT ⁶⁷ 187681002

ICD10 ³² C10.1

UMLS ⁷¹ C0496765 C0585946 C1112382

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Summaries for Epiglottis Cancer

MalaCards based summary : Epiglottis Cancer, also known as malignant tumor of epiglottis, is related to glomeruloid hemangioma and lower lip cancer. An important gene associated with Epiglottis Cancer is ABO (ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Hematopoietic cell lineage. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Epiglottis Cancer

Diseases related to Epiglottis Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Related Disease	Score	Top Affiliating Genes
1	glomeruloid hemangioma	10.3	ENG CD34
2	lower lip cancer	10.3	ENG CD34
3	inflammatory liposarcoma	10.2	CYGB CD34
4	colonic lymphangioma	10.2	PDPN CD34
5	hobnail hemangioma	10.2	PDPN CD34
6	rh isoimmunization	10.2	EPO ABO
7	testicular fibroma	10.2	PDPN CD34
8	atypical neurofibroma	10.2	PDPN CD34
9	supraglottis neoplasm	10.2	PDPN CAGE1
10	lymphangiosarcoma	10.2	PDPN CD34
11	malignant giant cell tumor of soft parts	10.2	ENG CD34 ACP5
12	cystic lymphangioma	10.1	PDPN CD34
13	benign peritoneal mesothelioma	10.1	PDPN CD34
14	myelophthisic anemia	10.1	EPO CD34
15	dacryocystocele	10.1	PDPN CAGE1
16	chronic inflammation of lacrimal passage	10.1	PDPN CAGE1
17	stress polycythemia	10.1	EPO CYGB
18	folic acid deficiency anemia	10.1	EPO CYGB
19	neonatal anemia	10.1	EPO ENG
20	periapical periodontitis	10.1	MMP8 ACP5
21	late congenital syphilis	10.1	ENG DDX41
22	acquired polycythemia	10.1	EPO CYGB
23	ischemic bone disease	10.1	ENG ACP5
24	esophageal tuberculosis	10.1	PDPN CYGB
25	splenic sequestration	10.1	EPO CYGB
26	capillary hemangioma	10.0	PDPN CD34
27	supraglottis cancer	10.0	PDPN MMP8
28	lip cancer	10.0	PDPN MMP8
29	capillary lymphangioma	10.0	PDPN ENG CD34
30	congenital granular cell tumor	10.0	PDPN ENG CD34
31	vascular cancer	10.0	PDPN ENG CD34
32	cardiovascular organ benign neoplasm	10.0	PDPN ENG CD34
33	osteonecrosis	10.0	MMP8 ENG ACP5
34	hemangioma	10.0	PDPN ENG CD34
35	anus cancer	10.0	MMP8 CAGE1
36	funisitis	10.0	S100A8 MMP8
37	cardiovascular cancer	9.9	PDPN CD34
38	microinvasive gastric cancer	9.9	S100A8 PDPN
39	esophagus sarcoma	9.9	PDPN CYGB CD34
40	squamous cell carcinoma	9.9
41	verrucous carcinoma	9.9
42	mucoepidermoid carcinoma	9.9
43	central epithelioid sarcoma	9.9	CD34 CD1D
44	vulvar proximal-type epithelioid sarcoma	9.9	CD34 CD1D
45	deficiency anemia	9.9	EPO CYGB CD34
46	blood platelet disease	9.9	EPO CYGB CD34
47	hemangioblastoma	9.8	PDPN EPO CD34
48	laryngeal benign neoplasm	9.8	PDPN MMP8 CAGE1
49	adult xanthogranuloma	9.8	CD34 CD1D
50	glottis neoplasm	9.8	MMP8 CD1D

Graphical network of the top 20 diseases related to Epiglottis Cancer:

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Symptoms & Phenotypes for Epiglottis Cancer

GenomeRNAi Phenotypes related to Epiglottis Cancer according to GeneCards Suite gene sharing:

²⁶ (show all 29)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.94	ABO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.94	NONO
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.94	NONO
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	9.94	NONO
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.94	NONO
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.94	DDX41
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.94	ABO
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-154	9.94	DDX41
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-158	9.94	DDX41
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.94	NONO
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-171	9.94	NONO
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.94	MMP8
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.94	NONO
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.94	ABO
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	9.94	ABO DDX41
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	9.94	NONO
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	9.94	MMP8
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-209	9.94	MMP8
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.94	NONO
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	9.94	DDX41
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.94	DDX41
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-24	9.94	DDX41
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-41	9.94	MMP8
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.94	NONO
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-5	9.94	MMP8
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-51	9.94	DDX41
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.94	MMP8
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.94	NONO
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.94	MMP8

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Drugs & Therapeutics for Epiglottis Cancer

Search Clinical Trials , NIH Clinical Center for Epiglottis Cancer

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Genetic Tests for Epiglottis Cancer

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Anatomical Context for Epiglottis Cancer

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Publications for Epiglottis Cancer

Articles related to Epiglottis Cancer:

#	Title	Authors	PMID	Year
1	[ABO blood groups in the patients with laryngeal cancer]. ⁶¹	Nowinska E...Kocierz S	10974887	2000
2	[Horizontal subglottic laryngectomy in treating cancers of the laryngeal vestibule and vallecula. Apropos of 65 cases]. ⁶¹	Godey B...Bourdiniere HJ	9207975	1996
3	ABO blood groups system in laryngeal cancer patients and after survival of 3 and 5 years. ⁶¹	Konieczna A...Turowski G	1308059	1992
4	[Curability of laryngeal cancer in relation to the starting point]. ⁶¹	Osmolski A...Kukulewska-Machnicka J	1808584	1991
5	[EPIGLOTTIS STRUCTURES IN EPIGLOTTIS CANCER (HISTOPATHOLOGIC STUDY AND CLINICAL CONSIDERATIONS)]. ⁶¹	LEONARDELLI GB...CIS C	14234508	1964

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Genes for Epiglottis Cancer

Genes related to Epiglottis Cancer (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ABO	ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase	Protein Coding	5.82	DISEASES inferred ¹⁵
2	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	5.41	DISEASES inferred ¹⁵
3	ENG	Endoglin	Protein Coding	5.07	DISEASES inferred ¹⁵
4	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	4.58	DISEASES inferred ¹⁵
5	CD34	CD34 Molecule	Protein Coding	4.3	DISEASES inferred ¹⁵
6	CAGE1	Cancer Antigen 1	Protein Coding	4.28	DISEASES inferred ¹⁵
7	S100A8	S100 Calcium Binding Protein A8	Protein Coding	4.15	DISEASES inferred ¹⁵
8	CYGB	Cytoglobin	Protein Coding	4.05	DISEASES inferred ¹⁵
9	PDPN	Podoplanin	Protein Coding	3.9	DISEASES inferred ¹⁵
10	MMP8	Matrix Metallopeptidase 8	Protein Coding	3.84	DISEASES inferred ¹⁵
11	DDX41	DEAD-Box Helicase 41	Protein Coding	3.56	DISEASES inferred ¹⁵
12	CD1D	CD1d Molecule	Protein Coding	3.55	DISEASES inferred ¹⁵
13	EPO	Erythropoietin	Protein Coding	3.38	DISEASES inferred ¹⁵

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Variations for Epiglottis Cancer

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Expression for Epiglottis Cancer

Search GEO for disease gene expression data for Epiglottis Cancer.

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Pathways for Epiglottis Cancer

Pathways related to Epiglottis Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.2	EPO ENG CD34
2	Hematopoietic cell lineage ³⁶	10.79	EPO CD34 CD1D

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GO Terms for Epiglottis Cancer

Cellular components related to Epiglottis Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.92	EPO ENG CD34 CD1D

Biological processes related to Epiglottis Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to lipopolysaccharide	GO:0032496	9.33	S100A8 EPO ACP5
2	negative regulation of nitric oxide biosynthetic process	GO:0045019	8.96	CD34 ACP5
3	response to hyperoxia	GO:0055093	8.62	PDPN EPO

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Sources for Epiglottis Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia