MCID: EPG001
MIFTS: 28

Epiglottis Neoplasm

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Epiglottis Neoplasm

MalaCards integrated aliases for Epiglottis Neoplasm:

Name: Epiglottis Neoplasm 12 15
Neoplasm of Epiglottis 12 70
Epiglottic Carcinoma 70
Epiglottic Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7105
NCIt 50 C4933
SNOMED-CT 67 126699008
UMLS 70 C1112382 C1290353

Summaries for Epiglottis Neoplasm

MalaCards based summary : Epiglottis Neoplasm, also known as neoplasm of epiglottis, is related to patella, chondromalacia of and hodgkin's lymphoma, nodular sclerosis. An important gene associated with Epiglottis Neoplasm is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and Immune response NFAT in immune response. Affiliated tissues include breast, lung and thymus, and related phenotypes are Reduced mammosphere formation and immune system

Related Diseases for Epiglottis Neoplasm

Diseases related to Epiglottis Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 patella, chondromalacia of 10.1 PIK3CA CD79A
2 hodgkin's lymphoma, nodular sclerosis 10.1 CD79A BCL6
3 pleural empyema 10.1 CD79A BCL6
4 breast papillomatosis 10.1 PIK3CA CCND1
5 infected hydrocele 10.1 CD79A CCND1
6 ethmoid sinus adenocarcinoma 10.1 PIK3CA CCND1
7 gastric lymphoma 10.1 CD79A BCL6
8 nodular lymphocyte predominant hodgkin lymphoma 10.1 CCND1 BCL6
9 hemimegalencephaly 10.1 PIK3CA CCND1
10 eye lymphoma 10.1 CD5 BCL6
11 extramedullary plasmacytoma 10.1 CD79A CCND1
12 actinobacillosis 10.1 CD79A CD5
13 ovarian mixed germ cell neoplasm 10.1 PIK3CA MME
14 hilar lung carcinoma 10.1 MME CD79A
15 lung hilum cancer 10.1 MME CD79A
16 soft palate cancer 10.1 CCND1 BCL6
17 liver lymphoma 10.1 MME CD79A
18 intraductal breast benign neoplasm 10.0 PIK3CA MME
19 cerebral lymphoma 10.0 MME CD79A
20 chest wall lymphoma 10.0 MME BCL6
21 ovarian lymphoma 10.0 MME BCL6
22 hidradenoma 10.0 PIK3CA MME
23 mulchandani-bhoj-conlin syndrome 10.0 PIK3CA MME
24 t-cell/histiocyte rich large b cell lymphoma 10.0 MME BCL6
25 mixed cell type cancer 10.0 PIK3CA MME
26 splenic disease 10.0 CD5 BCL6
27 endocrine exophthalmos 10.0 MME CD5
28 cryoglobulinemia 10.0 CD79A CD5
29 oropharynx cancer 10.0 PIK3CA CCND1
30 splenic marginal zone lymphoma 10.0 CD5 BCL6
31 penile cancer 10.0 PIK3CA CCND1
32 plasma protein metabolism disease 9.9 MME CD5
33 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9 PTPRC BCL6
34 uterine benign neoplasm 9.9 MME CCND1
35 reproductive organ benign neoplasm 9.9 MME CCND1
36 plasmablastic lymphoma 9.9 PTPRC BCL6
37 renal oncocytoma 9.9 MME CCND1
38 lymphosarcoma 9.9 PTPRC BCL6
39 angioimmunoblastic t-cell lymphoma 9.9 MME BCL6
40 prolymphocytic leukemia 9.9 CD5 CCND1
41 myeloid sarcoma 9.9 PTPRC CD79A
42 pre-malignant neoplasm 9.9 PIK3CA CCND1
43 reticulosarcoma 9.8 PTPRC BCL6
44 paranasal sinus lymphoma 9.8 MME CD79A BCL6
45 lymphangioma 9.8 PIK3CA CCND1
46 gray zone lymphoma 9.8 MME CD79A BCL6
47 pediatric lymphoma 9.8 MME CD79A BCL6
48 testicular lymphoma 9.8 MME CD79A BCL6
49 epididymis adenocarcinoma 9.8 PTPRC MME
50 epididymis cancer 9.8 PTPRC MME

Graphical network of the top 20 diseases related to Epiglottis Neoplasm:



Diseases related to Epiglottis Neoplasm

Symptoms & Phenotypes for Epiglottis Neoplasm

GenomeRNAi Phenotypes related to Epiglottis Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 BCL6 CCND1 CD5 CD79A PTPRC

MGI Mouse Phenotypes related to Epiglottis Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.91 BCL6 CCND1 CD5 CD79A MME PIK3CA
2 cellular MP:0005384 9.88 BCL6 CCND1 CD79A MME PIK3CA PTPRC
3 integument MP:0010771 9.8 BCL6 CCND1 CD5 MME PIK3CA PTPRC
4 nervous system MP:0003631 9.63 CCND1 CD5 CD79A MME PIK3CA PTPRC
5 neoplasm MP:0002006 9.56 CCND1 CD79A PIK3CA PTPRC
6 no phenotypic analysis MP:0003012 9.35 BCL6 CD5 CD79A PIK3CA PTPRC
7 normal MP:0002873 9.02 BCL6 CCND1 CD5 CD79A PTPRC

Drugs & Therapeutics for Epiglottis Neoplasm

Search Clinical Trials , NIH Clinical Center for Epiglottis Neoplasm

Genetic Tests for Epiglottis Neoplasm

Anatomical Context for Epiglottis Neoplasm

MalaCards organs/tissues related to Epiglottis Neoplasm:

40
Breast, Lung, Thymus, Eye, Bone, Spleen, Heart

Publications for Epiglottis Neoplasm

Articles related to Epiglottis Neoplasm:

# Title Authors PMID Year
1
[Successful fiberoptic tracheal intubation via Cobra PLA in a patient with an epiglottic tumor]. 61
19364014 2009
2
Extramedullary plasmacytoma of the larynx. 61
16406428 2006

Variations for Epiglottis Neoplasm

Expression for Epiglottis Neoplasm

Search GEO for disease gene expression data for Epiglottis Neoplasm.

Pathways for Epiglottis Neoplasm

Pathways related to Epiglottis Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 PTPRC PIK3CA MME CD79A CCND1 BCL6
2
Show member pathways
12.29 PTPRC PIK3CA CD79A
3 12.19 PTPRC CD79A BCL6
4
Show member pathways
12.06 PTPRC PIK3CA BCL6
5
Show member pathways
11.99 PTPRC PIK3CA CD79A BCL6
6
Show member pathways
11.65 PTPRC PIK3CA CD79A BCL6
7
Show member pathways
11.63 PIK3CA CCND1 BCL6
8 11.49 PIK3CA CCND1 BCL6
9 11.4 PIK3CA CCND1
10 11.37 PIK3CA BCL6
11
Show member pathways
11.33 PIK3CA CCND1
12 11.27 PIK3CA CCND1
13 11.26 PIK3CA CCND1
14 11.06 PTPRC CD79A
15 10.99 PTPRC MME CD79A CD5
16 10.95 PIK3CA CCND1
17 10.91 PIK3CA CCND1
18 10.87 PTPRC MME

GO Terms for Epiglottis Neoplasm

Cellular components related to Epiglottis Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 PTPRC CD79A CD5
2 membrane raft GO:0045121 8.8 PTPRC MME CD79A

Biological processes related to Epiglottis Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 PIK3CA CCND1 BCL6
2 T cell costimulation GO:0031295 9.32 PIK3CA CD5
3 positive regulation of B cell proliferation GO:0030890 9.26 PTPRC BCL6
4 B cell proliferation GO:0042100 8.96 PTPRC CD79A
5 B cell differentiation GO:0030183 8.8 PTPRC CD79A BCL6

Sources for Epiglottis Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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