MCID: EPG003
MIFTS: 34

Epiglottitis

Categories: Respiratory diseases

Aliases & Classifications for Epiglottitis

MalaCards integrated aliases for Epiglottitis:

Name: Epiglottitis 12 55 44 15 73
Acute Epiglottitis 12 73
Acute Epiglottitis and Supraglottitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9398
ICD10 33 J05.1 J05.10
ICD9CM 35 464.3
MeSH 44 D004826
NCIt 50 C116007

Summaries for Epiglottitis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor.

MalaCards based summary : Epiglottitis, also known as acute epiglottitis, is related to epiglottis neoplasm and croup. An important gene associated with Epiglottitis is OMP (Olfactory Marker Protein). The drugs Vaccines and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, trachea and tongue, and related phenotype is shRNA abundance <= 50%.

Wikipedia : 76 Epiglottitis is inflammation of the epiglottis—the flap at the base of the tongue that keeps food from... more...

Related Diseases for Epiglottitis

Graphical network of the top 20 diseases related to Epiglottitis:



Diseases related to Epiglottitis

Symptoms & Phenotypes for Epiglottitis

GenomeRNAi Phenotypes related to Epiglottitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.02 DNASE1L3 DNM1 OMP SUCLG2 TIRAP

Drugs & Therapeutics for Epiglottitis

Drugs for Epiglottitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Antibodies Phase 3
3 Immunoglobulins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Persistency Study After Hib-CRM (Cross-Reacting Material)197 or Hib-TT (Tetanus Toxoid) Vaccines in Chinese Children Completed NCT02139228 Phase 3

Search NIH Clinical Center for Epiglottitis

Cochrane evidence based reviews: epiglottitis

Genetic Tests for Epiglottitis

Anatomical Context for Epiglottitis

MalaCards organs/tissues related to Epiglottitis:

41
Skin, Trachea, Tongue, Bone, B Cells, Myeloid, Bone Marrow

Publications for Epiglottitis

Articles related to Epiglottitis:

(show top 50) (show all 577)
# Title Authors Year
1
Meningococcal serogroup W135 epiglottitis in an adolescent patient. ( 29507021 )
2018
2
Case Report of a 5-Year-Old With Epiglottitis: An Atypical Presentation of an Uncommon Disease. ( 29232352 )
2018
3
Acute Epiglottitis in a Diabetic Adult Patient. ( 29271392 )
2018
4
Risk of acute epiglottitis in patients with preexisting diabetes mellitus: A population-based case-control study. ( 29889887 )
2018
5
Sudden death from acute epiglottitis in a toddler. ( 29926438 )
2018
6
Acute Epiglottitis in the Immunocompromised Host: Case Report and Review of the Literature. ( 29564363 )
2018
7
Acute epiglottitis with intramural oesophageal dissection. ( 29514834 )
2018
8
<i>Neisseria meningitidis</i> sepsis in a patient with acute epiglottitis and respiratory failure. ( 29804070 )
2018
9
Unexpected custodial death due to acute epiglottitis: A rare autopsy case report. ( 29443781 )
2018
10
Meningococcal epiglottitis in a healthy adult patient: The first documented case in Australia. ( 29797406 )
2018
11
Thumb and vallecula signs in acute infectious epiglottitis. ( 29038322 )
2017
12
Epiglottitis as the Presenting Sign of Mucous Membranous Pemphigoid: A Case Report. ( 28479314 )
2017
13
Multicenter study on the effectiveness of the pre-epiglottic baton plate for airway obstruction and feeding problems in Robin sequence. ( 28274235 )
2017
14
A case report of epiglottitis. ( 28194902 )
2017
15
Adult onset Kawasaki disease presenting with acute epiglottitis findings. ( 29102400 )
2017
16
Spontaneous Respiration Using Intravenous Anesthesia and High-Flow Nasal Oxygen (STRIVE Hi) Management of Acute Adult Epiglottitis: A Case Report. ( 28953487 )
2017
17
Haemophilus influenzae Serotype f Epiglottitis: A Case Report and Review. ( 28028010 )
2017
18
Acute epiglottitis in an older person. ( 28043981 )
2017
19
A Rare Case of Candida Epiglottitis in an Immunocompetent Child. ( 28248840 )
2017
20
Epiglottitis ( 28613691 )
2017
21
Adult Epiglottitis: A Case Series. ( 28241903 )
2017
22
Do we need a change in ED diagnostic strategy for adult acute epiglottitis? ( 28460811 )
2017
23
Clinical evaluation of intravenous ampicillin as empirical antimicrobial treatment of acute epiglottitis. ( 28826305 )
2017
24
Hypertrophic pachymeningitis of the craniocervical junction mimicking acute epiglottitis. ( 27444111 )
2016
25
Epiglottitis: It Hasn't Gone Away. ( 27031010 )
2016
26
Laryngomalacia with Epiglottic Prolapse Obscuring the Laryngeal Inlet. ( 27433749 )
2016
27
Airway Obstruction Secondary to Emphysematous Epiglottitis: A Case Report. ( 27821835 )
2016
28
An Unusual Presentation of B-Cell Lymphoma as a Large Isolated Epiglottic Mass: Case Report and Literature Review. ( 27213065 )
2016
29
Sudden Death Due to Acute Epiglottitis in Adults: A Retrospective Review of 11 Postmortem Cases. ( 27617418 )
2016
30
Thumb sign: acute epiglottitis. ( 27247205 )
2016
31
Concurrent uvulitis and epiglottitis. ( 27726831 )
2016
32
Management of acute epiglottitis in an infant with a family history of malignant hyperthermia. ( 26742949 )
2016
33
A Case of Necrotizing Epiglottitis Due to Nontoxigenic Corynebacterium diphtheriae. ( 26055849 )
2015
34
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015
35
Long-term outcome of critically ill adult patients with acute epiglottitis. ( 25945804 )
2015
36
Images in clinical medicine. Epiglottitis in an adult. ( 25853768 )
2015
37
Cervical necrotizing fasciitis as a complication of acute epiglottitis managed with minimally aggressive surgical intervention: Case report. ( 26214679 )
2015
38
EBV epiglottitis: Primary supraglottic viral infection in a pediatric immunocompetent host. ( 26298621 )
2015
39
Prolonged Stridor and Epiglottitis With Concurrent Bacterial and Viral Etiologies. ( 25926662 )
2015
40
Surgical treatment of a case of adult epiglottic laryngomalacia. ( 25614370 )
2015
41
Intubation of Patients with Acute Epiglottitis in the Emergency Department Using a Gum Elastic Bougie as an Adjunct. ( 24397715 )
2014
42
Acute epiglottitis from corrosive ingestion. ( 25136202 )
2014
43
Factors associated with severe epiglottitis in adults: Analysis of a Japanese inpatient database. ( 25546701 )
2014
44
Adult epiglottitis complicated by negative pressure pulmonary edema. ( 24853158 )
2014
45
Aphonia and epiglottitis in neonate with concomitant MRSA skin infection. ( 25473587 )
2014
46
Difficult airway management in a patient with combined severe deep neck abscess and acute epiglottitis with abscess. ( 25439424 )
2014
47
A method of transoral finger dissection for a giant epiglottic lipoma. ( 25405047 )
2014
48
Epiglottitis as a presentation of leukemia in an adolescent. ( 25275354 )
2014
49
A novel case of adult, acute epiglottitis successfully treated with noninvasive ventilation. ( 25611365 )
2014
50
Acute epiglottitis in adults: an under-recognized and life-threatening condition. ( 24175495 )
2013

Variations for Epiglottitis

Expression for Epiglottitis

Search GEO for disease gene expression data for Epiglottitis.

Pathways for Epiglottitis

GO Terms for Epiglottitis

Cellular components related to Epiglottitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.62 DNM1 RDH11

Sources for Epiglottitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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