MCID: EPG003
MIFTS: 35

Epiglottitis

Categories: Respiratory diseases

Aliases & Classifications for Epiglottitis

MalaCards integrated aliases for Epiglottitis:

Name: Epiglottitis 12 56 45 15 17 74
Acute Epiglottitis 12 74
Acute Epiglottitis and Supraglottitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9398
ICD9CM 36 464.3
MeSH 45 D004826
NCIt 51 C116007
SNOMED-CT 69 29608009 80384002
ICD10 34 J05.1 J05.10

Summaries for Epiglottitis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor.

MalaCards based summary : Epiglottitis, also known as acute epiglottitis, is related to epiglottis neoplasm and epiglottis cancer. An important gene associated with Epiglottitis is OMP (Olfactory Marker Protein), and among its related pathways/superpathways is Pertussis. The drugs Immunoglobulins and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and trachea, and related phenotype is shRNA abundance <= 50%.

Wikipedia : 77 Epiglottitis is inflammation of the epiglottis—the flap at the base of the tongue that keeps food from... more...

Related Diseases for Epiglottitis

Graphical network of the top 20 diseases related to Epiglottitis:



Diseases related to Epiglottitis

Symptoms & Phenotypes for Epiglottitis

GenomeRNAi Phenotypes related to Epiglottitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 8.92 DNM1 OMP SERPING1 TIRAP

Drugs & Therapeutics for Epiglottitis

Drugs for Epiglottitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Vaccines Phase 3
3 Antibodies Phase 3
4 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Persistency Study After Hib-CRM (Cross-Reacting Material)197 or Hib-TT (Tetanus Toxoid) Vaccines in Chinese Children Completed NCT02139228 Phase 3

Search NIH Clinical Center for Epiglottitis

Cochrane evidence based reviews: epiglottitis

Genetic Tests for Epiglottitis

Anatomical Context for Epiglottitis

MalaCards organs/tissues related to Epiglottitis:

42
Skin, Tongue, Trachea, Colon, Bone, Brain, Bone Marrow

Publications for Epiglottitis

Articles related to Epiglottitis:

(show top 50) (show all 768)
# Title Authors Year
1
Meningococcal serogroup W135 epiglottitis in an adolescent patient. ( 29507021 )
2018
2
Case Report of a 5-Year-Old With Epiglottitis: An Atypical Presentation of an Uncommon Disease. ( 29232352 )
2018
3
Acute Epiglottitis in a Diabetic Adult Patient. ( 29271392 )
2018
4
Risk of acute epiglottitis in patients with preexisting diabetes mellitus: A population-based case-control study. ( 29889887 )
2018
5
Sudden death from acute epiglottitis in a toddler. ( 29926438 )
2018
6
Acute Epiglottitis in the Immunocompromised Host: Case Report and Review of the Literature. ( 29564363 )
2018
7
Acute epiglottitis with intramural oesophageal dissection. ( 29514834 )
2018
8
<i>Neisseria meningitidis</i> sepsis in a patient with acute epiglottitis and respiratory failure. ( 29804070 )
2018
9
Unexpected custodial death due to acute epiglottitis: A rare autopsy case report. ( 29443781 )
2018
10
Meningococcal epiglottitis in a healthy adult patient: The first documented case in Australia. ( 29797406 )
2018
11
Epiglottitis. ( 30048357 )
2018
12
Necrotizing epiglottitis treated with early surgical debridement: A case report. ( 30064927 )
2018
13
Review of epiglottitis in the post Haemophilus influenzae type-b vaccine era. ( 30207030 )
2018
14
Accuracy of objective parameters in acute epiglottitis diagnosis: A case-control study. ( 30212960 )
2018
15
Traumatic Epiglottitis following a Blind Insertion of the Hand during Convulsion. ( 30245901 )
2018
16
Influenza A-Associated Epiglottitis and Compensatory Pursed Lip Breathing in an Infant. ( 30247455 )
2018
17
A Lot to Choke on: Case of Adult Epiglottitis with Concurrent Peritonsillar Abscess in a Patient with a Sore Throat. ( 30342860 )
2018
18
Acute Epiglottitis with Concurrent Pneumonia and Septic Shock in an Alcoholic Adult Patient. ( 30443621 )
2018
19
Acute epiglottitis caused by community-acquired methicillin-resistant Staphylococcus aureus in a healthy infant. ( 30464548 )
2018
20
A case report of serotype W135 Neisseria meningitidis epiglottitis in the United States and review of twelve adult cases of meningococcal epiglottitis. ( 30479961 )
2018
21
Application of superior laryngeal nerve block and videolaryngoscope for awake intubation in a patient with severe acute epiglottitis. ( 30544034 )
2018
22
Heamophilus Influenza-B Epiglottitis in a Vaccinated Child: A Note of Caution. ( 30550013 )
2018
23
Adult epiglottitis: Trends and predictors of mortality in over 30 thousand cases from 2007 to 2014. ( 30582183 )
2018
24
Back to Basics: A Case of Adult Epiglottitis. ( 30613442 )
2018
25
Thumb and vallecula signs in acute infectious epiglottitis. ( 29038322 )
2017
26
Epiglottitis as the Presenting Sign of Mucous Membranous Pemphigoid: A Case Report. ( 28479314 )
2017
27
A case report of epiglottitis. ( 28194902 )
2017
28
Adult onset Kawasaki disease presenting with acute epiglottitis findings. ( 29102400 )
2017
29
Spontaneous Respiration Using Intravenous Anesthesia and High-Flow Nasal Oxygen (STRIVE Hi) Management of Acute Adult Epiglottitis: A Case Report. ( 28953487 )
2017
30
Haemophilus influenzae Serotype f Epiglottitis: A Case Report and Review. ( 28028010 )
2017
31
Acute epiglottitis in an older person. ( 28043981 )
2017
32
A Rare Case of Candida Epiglottitis in an Immunocompetent Child. ( 28248840 )
2017
33
Epiglottitis ( 28613691 )
2017
34
Adult Epiglottitis: A Case Series. ( 28241903 )
2017
35
Do we need a change in ED diagnostic strategy for adult acute epiglottitis? ( 28460811 )
2017
36
Clinical evaluation of intravenous ampicillin as empirical antimicrobial treatment of acute epiglottitis. ( 28826305 )
2017
37
Pasteurella multocida Epiglottitis. ( 29849414 )
2017
38
Hypertrophic pachymeningitis of the craniocervical junction mimicking acute epiglottitis. ( 27444111 )
2016
39
Epiglottitis: It Hasn't Gone Away. ( 27031010 )
2016
40
Airway Obstruction Secondary to Emphysematous Epiglottitis: A Case Report. ( 27821835 )
2016
41
Sudden Death Due to Acute Epiglottitis in Adults: A Retrospective Review of 11 Postmortem Cases. ( 27617418 )
2016
42
Thumb sign: acute epiglottitis. ( 27247205 )
2016
43
Concurrent uvulitis and epiglottitis. ( 27726831 )
2016
44
Management of acute epiglottitis in an infant with a family history of malignant hyperthermia. ( 26742949 )
2016
45
Airway intervention in cases of acute epiglottitis. ( 29709131 )
2016
46
A Case of Necrotizing Epiglottitis Due to Nontoxigenic Corynebacterium diphtheriae. ( 26055849 )
2015
47
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015
48
Long-term outcome of critically ill adult patients with acute epiglottitis. ( 25945804 )
2015
49
Images in clinical medicine. Epiglottitis in an adult. ( 25853768 )
2015
50
Cervical necrotizing fasciitis as a complication of acute epiglottitis managed with minimally aggressive surgical intervention: Case report. ( 26214679 )
2015

Variations for Epiglottitis

Expression for Epiglottitis

Search GEO for disease gene expression data for Epiglottitis.

Pathways for Epiglottitis

Pathways related to Epiglottitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 SERPING1 TIRAP

GO Terms for Epiglottitis

Cellular components related to Epiglottitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.62 DNM1 RDH11

Sources for Epiglottitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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