SCFE
MCID: EPP010
MIFTS: 30

Epiphysiolysis of the Hip (SCFE)

Categories: Bone diseases, Oral diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Epiphysiolysis of the Hip

MalaCards integrated aliases for Epiphysiolysis of the Hip:

Name: Epiphysiolysis of the Hip 58
Slipped Upper Femoral Epiphysis 58 31 33
Non-Traumatic Slipped Upper Femoral Epiphysis 33
Scfe - [slipped Capital Femoral Epiphysis] 33
Sufe - [slipped Upper Femoral Epiphysis] 33
Slipped Upper Femoral Epiphysis Nos 33
Epiphysiolysis of the Upper Femur 58
Slipped Capital Femoral Epiphysis 58
Slipped Capital Femoral Epiphyses 71
Femoral Head Epiphysiolysis 58
Slipped Femoral Epiphysis 33
Scfe 58
Sufe 58

Characteristics:


Age Of Onset:

Adolescent,Childhood 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 31 M93.0
ICD10 via Orphanet 32 M93.9
Orphanet 58 ORPHA399329
ICD11 33 168053259
UMLS 71 C0149887

Summaries for Epiphysiolysis of the Hip

Orphanet: 58 Epiphysiolysis of the hip is a rare osteonecrosis disorder characterized by unilateral or bilateral disruption of the capital femoral physis with varying degrees of posterior epiphysis translation and simultaneous anterior metaphysis displacement. Patients typically present in pre-adolescence/adolescence with pain of variable intensity in varying locations (hip, groin, thigh, knee).

MalaCards based summary: Epiphysiolysis of the Hip, also known as slipped upper femoral epiphysis, is related to epiphyseal chondrodysplasia, miura type and hypogonadism. The drugs Sodium Chloride Symporter Inhibitors and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and bone marrow.

Related Diseases for Epiphysiolysis of the Hip

Diseases related to Epiphysiolysis of the Hip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 epiphyseal chondrodysplasia, miura type 11.7
2 hypogonadism 10.9
3 hyperparathyroidism 10.9
4 pituitary hormone deficiency, combined, 2 10.8
5 primary hyperparathyroidism 10.8
6 body mass index quantitative trait locus 1 10.8
7 cartilage disease 10.8
8 renal osteodystrophy 10.8
9 blount's disease 10.8
10 hypopituitarism 10.7
11 growth hormone deficiency 10.7
12 parathyroid adenoma 10.7
13 overgrowth syndrome 10.7
14 osseous heteroplasia, progressive 10.6
15 down syndrome 10.6
16 leptin deficiency or dysfunction 10.6
17 synovitis 10.6
18 adenoma 10.6
19 oculodentodigital dysplasia 10.6
20 bone disease 10.6
21 hypogonadotropic hypogonadism 10.6
22 osteopetrosis 10.6
23 multiple endocrine neoplasia 10.6
24 hypogonadotropic hypogonadism 7 with or without anosmia 10.6
25 acromegaly 10.6
26 craniopharyngioma 10.6
27 developmental dysplasia of the hip 1 10.5
28 prader-willi syndrome 10.5
29 papillon-lefevre syndrome 10.5
30 otopalatodigital syndrome, type ii 10.5
31 otopalatodigital syndrome, type i 10.5
32 chromosome 16p13.3 deletion syndrome, proximal 10.5
33 scoliosis 10.5
34 cerebral palsy 10.5
35 ankylosis 10.5
36 pseudohypoparathyroidism 10.5
37 septic arthritis 10.5
38 pik3ca-related overgrowth spectrum 10.5
39 47 xxx syndrome 10.5
40 49, xxxxy syndrome 10.5
41 pituitary tumors 10.5
42 pik3ca-related overgrowth syndrome 10.5
43 avascular necrosis 10.5
44 slipped femoral capital epiphyses 10.4
45 intracranial hypertension, idiopathic 10.4
46 body mass index quantitative trait locus 11 10.4
47 body mass index quantitative trait locus 9 10.4
48 body mass index quantitative trait locus 8 10.4
49 sickle cell anemia 10.4
50 bone mineral density quantitative trait locus 3 10.4

Graphical network of the top 20 diseases related to Epiphysiolysis of the Hip:



Diseases related to Epiphysiolysis of the Hip

Symptoms & Phenotypes for Epiphysiolysis of the Hip

Drugs & Therapeutics for Epiphysiolysis of the Hip

Drugs for Epiphysiolysis of the Hip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Sodium Chloride Symporter Inhibitors Phase 4
2 diuretics Phase 4
3 Gentamicins Phase 4

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
2 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
3 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle™ Acetabular Cup Prosthesis With a Ceramic-on-ceramic Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00872222 Phase 4
4 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
5 Prospective, Uncontrolled, Multi-Centre, Post-Marketing Surveillance Study to Evaluate the Long-Term Performance of Summit Tapered Hip in Cementless Total Hip Arthroplasty Terminated NCT00208390 Phase 4
6 Prospective Multi-Centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-Term Performance of the DePuy ASR Hip System in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00208377 Phase 4
7 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup Prosthesis With a Metal on Metal Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00208364 Phase 4
8 Prospective Single-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of the DePuy ASR™ Hip in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00872794 Phase 4
9 Prospective, International Multi-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of a Large Metal-on-Metal (MoM) Bearing Comprising a DePuy ASR™ Cup in Conjunction With Either a DePuy ASR™ Hip Resurfacing Femoral Component or a DePuy ASR™ XL Head in Subjects With Indications Suitable for Either a Primary Resurfacing Arthroplasty or Primary Total Hip Arthroplasty Terminated NCT00872547 Phase 4
10 Prospective, Uncontrolled, Two-centre, RSA, Post-market Surveillance Study to Evaluate the Stability of the C-Stem™ AMT Femoral Component in Primary Total Hip Arthroplasty. Terminated NCT00872573 Phase 4
11 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup System With a Metal on Enduron Polyethylene Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
12 Clinical and Radiographic Evaluation to Compare a Polished and Non-polished Collared Stem and a Polished and Non Polished Collarless Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
13 A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement Terminated NCT00208468 Phase 3
14 Slipped Capital Femoral Epiphysis; Changes in Gait, Balance and Muscle Activity Patterns in Patients Treated With Single Screw in Situ Fixation Investigated Using Computer Assisted Rehabilitation ENvironment (CAREN) Unknown status NCT03326531
15 Safe Surgical Dislocation in Slipped Capital Femoral Epiphysis Unknown status NCT03229590
16 Skeletal Age Assessment From the Olecranon For Slipped Capital Femoral Epiphysis Unknown status NCT01220882
17 SLIP Registry - SCFE Longitudinal International Prospective Registry Recruiting NCT04117841

Search NIH Clinical Center for Epiphysiolysis of the Hip

Genetic Tests for Epiphysiolysis of the Hip

Anatomical Context for Epiphysiolysis of the Hip

Organs/tissues related to Epiphysiolysis of the Hip:

MalaCards : Bone, Pituitary, Bone Marrow, Thyroid, Tongue, Eye, Kidney

Publications for Epiphysiolysis of the Hip

Articles related to Epiphysiolysis of the Hip:

(show top 50) (show all 1897)
# Title Authors PMID Year
1
Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis. 62
35802155 2022
2
Skeletal Outcomes in Children and Young Adults with Glomerular Disease. 62
36171052 2022
3
Erratum zu: Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis. 62
35948650 2022
4
Presence and magnitude of anterior physeal separation in slipped upper femoral epiphysis helps identifying those at high risk for avascular necrosis. 62
36307269 2022
5
A review of slipped capital femoral epiphysis. 62
36412940 2022
6
Early Total Hip Arthroplasty is a Cost-Effective Treatment for Severe Radiographic Slipped Capital Femoral Epiphysis Over an Individual's Lifetime. 62
36470363 2022
7
Avascular Necrosis and Time to Surgery for Unstable Slipped Capital Femoral Epiphysis: A Systematic Review and Meta-analysis. 62
35941089 2022
8
Limited Hip Flexion and Internal Rotation Resulting From Early Hip Impingement Conflict on Anterior Metaphysis of Patients With Untreated Severe SCFE Using 3D Modelling. 62
36099440 2022
9
The Utility of Virtual Reality in Orthopedic Surgical Training. 62
35821110 2022
10
Characterizing the Residual SCFE Deformity: Utility of the 45-degree Dunn View. 62
36037440 2022
11
Modified Dunn procedure versus percutaneous pinning in moderate/severe stable slipped capital femoral epiphyses. 62
33829904 2022
12
Quality of YouTube videos for three common pediatric hip conditions: developmental hip dysplasia, slipped capital femoral epiphysis and Legg-Calve-Perthes disease. 62
35357371 2022
13
Physical disability in Late Antiquity Milan: slipped capital femoral epiphysis with severe secondary joint disease in the Basilica of San Dionigi. 62
36218258 2022
14
Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression. 62
36288602 2022
15
Clinical and radiological outcomes following surgical hip dislocation for paediatric hip pathologies, a prospective cohort study. 62
36307306 2022
16
Readability of online patient educational materials for common orthopaedic paediatric conditions within Australasia. 62
36221204 2022
17
Avascular Necrosis After Modified Dunn Surgery for the Treatment of Slipped Capital Femoral Epiphysis. 62
36226215 2022
18
Outcomes in Pediatric Hip FAI Surgery: a Scoping Review. 62
35917094 2022
19
Risk of Avascular Necrosis with The Modified Dunn Procedure in SCFE Patients: A Meta-Analysis. 62
36360408 2022
20
Unusual Age of Presentation and Etiology of Slipped Capital Femoral Epiphysis Following a Seizure Attack: A Case Report. 62
36465788 2022
21
Increasing incidence of slipped capital femoral epiphysis in Trinidad and Tobago: A 50-year review. 62
36214270 2022
22
Prospective evaluation of in situ screw fixation for stable slipped capital femoral epiphysis. 62
36238141 2022
23
Hardware Impingement Is Associated With Shorter Screw Length in Patients Treated With In Situ Screw Fixation for Slipped Capital Femoral Epiphysis: An In Vivo Arthroscopic Evaluation. 62
36312729 2022
24
Prevalence of Avascular Necrosis Following Surgical Treatments in Unstable Slipped Capital Femoral Epiphysis (SCFE): A Systematic Review and Meta-Analysis. 62
36138683 2022
25
The contralateral hip in slipped capital femoral epiphysis: Is there an easy-to-use algorithm to support a decision for prophylactic fixation? 62
35992523 2022
26
Screw Thread Configuration Has No Effect on Outcomes of In Situ Fixation for Stable Slipped Capital Femoral Epiphysis. 62
35671226 2022
27
Are children with obesity at school entry more likely to have a diagnosis of a musculoskeletal condition? Findings from a systematic review. 62
36053659 2022
28
Development and Validation of SCFE Percutaneous Pinning Surgical Simulation. 62
35319527 2022
29
Long-term follow up of 44 cats undergoing total hip replacement: Cases from a feline hip registry (2010-2020). 62
35642440 2022
30
Is there a persistent capital femoral epiphysis growth after screw fixation for slipped capital femoral epiphysis? 62
35854809 2022
31
Controlled repositioning and primary osteoplasty as a treatment option for the management of unstable slipped capital femoral epiphysis. 62
35620839 2022
32
A Retrospective Study of Risk Factors and Outcomes in the Surgical Management of Slipped Capital Femoral Epiphysis. 62
35794815 2022
33
Is the level of vitamin D deficiency correlated with the severity and bilaterality in slipped capital femoral epiphysis? A case series study. 62
36001825 2022
34
Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a 12-Year-Old With Slipped Capital Femoral Epiphysis. 62
35592510 2022
35
Central precocious puberty with hypothalamic hamartoma; the first case reports of two siblings with different phenotypes in Seckel syndrome 5. 62
35798296 2022
36
Identification of musculoskeletal problems using pGALS examination in school going boys in Chennai, India. 62
36119161 2022
37
Slipped upper femoral epiphysis: An important cause of paediatric hip pain. 62
35637586 2022
38
Telescoping screw fixation compared to traditional in situ screw fixation for slipped capital femoral epiphysis: clinical, radiographic and patient-reported outcomes. 62
34050119 2022
39
Risk factors for early symptomatic femoroacetabular impingement following in situ fixation of slipped capital femoral epiphysis. 62
35462635 2022
40
Minimal Out-Toeing and Good Hip Scores of Severe SCFE Patients Treated With Modified Dunn Procedure and Contralateral Prophylactic Pinning at Minimal 5-year Follow up. 62
35250015 2022
41
Outcomes and Survivorship at a Median of 8.9 Years Following Hip Arthroscopy in Adolescents with Femoroacetabular Impingement: A Matched Comparative Study with Adults. 62
35255011 2022
42
Prophylactic fixation of the unaffected contralateral side in children with slipped capital femoral epiphysis seems favorable: A systematic review. 62
35633749 2022
43
Proximal femoral changes related to obesity: an analysis of slipped capital femoral epiphysis pathoanatomy. 62
33720077 2022
44
Factors Affecting Slip Progression After In Situ Screw Fixation of Stable Slipped Capital Femoral Epiphysis. 62
35200211 2022
45
Slipped Capital Femoral Epiphysis Associated With Athletic Activity. 62
35502132 2022
46
Comparing complications of outpatient management of slipped capital femoral epiphysis and Blount's disease: A database study. 62
35582157 2022
47
The British Orthopaedic Surgery Surveillance study: slipped capital femoral epiphysis: the epidemiology and two-year outcomes from a prospective cohort in Great Britain. 62
35360942 2022
48
Xanthomatous hypophysitis causing hypogonadotropic hypogonadism resulting in delayed presentation of slipped capital femoral epiphysis. 62
30450996 2022
49
Evaluation of a Slipped Capital Femoral Epiphysis Virtual Reality Surgical Simulation for the Orthopaedic Trainee. 62
35467580 2022
50
Hypothyroidism Presenting as Slipped Capital Femoral Epiphysis. 62
35218254 2022

Variations for Epiphysiolysis of the Hip

Expression for Epiphysiolysis of the Hip

Search GEO for disease gene expression data for Epiphysiolysis of the Hip.

Pathways for Epiphysiolysis of the Hip

GO Terms for Epiphysiolysis of the Hip

Sources for Epiphysiolysis of the Hip

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....