Epiphysiolysis of the Hip disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ Epiphysiolysis of the hip is a rare osteonecrosis disorder characterized by unilateral or bilateral disruption of the capital femoral physis with varying degrees of posterior epiphysis translation and simultaneous anterior metaphysis displacement. Patients typically present in pre-adolescence/adolescence with pain of variable intensity in varying locations (hip, groin, thigh, knee).

MalaCards based summary: Epiphysiolysis of the Hip, also known as slipped upper femoral epiphysis, is related to epiphyseal chondrodysplasia, miura type and hypogonadism. The drugs Sodium Chloride Symporter Inhibitors and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and bone marrow.

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Related Diseases for Epiphysiolysis of the Hip

Diseases related to Epiphysiolysis of the Hip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)

#	Related Disease	Score
1	epiphyseal chondrodysplasia, miura type	11.7
2	hypogonadism	10.9
3	hyperparathyroidism	10.9
4	pituitary hormone deficiency, combined, 2	10.8
5	primary hyperparathyroidism	10.8
6	body mass index quantitative trait locus 1	10.8
7	cartilage disease	10.8
8	renal osteodystrophy	10.8
9	blount's disease	10.8
10	hypopituitarism	10.7
11	growth hormone deficiency	10.7
12	parathyroid adenoma	10.7
13	overgrowth syndrome	10.7
14	osseous heteroplasia, progressive	10.6
15	down syndrome	10.6
16	leptin deficiency or dysfunction	10.6
17	synovitis	10.6
18	adenoma	10.6
19	oculodentodigital dysplasia	10.6
20	bone disease	10.6
21	hypogonadotropic hypogonadism	10.6
22	osteopetrosis	10.6
23	multiple endocrine neoplasia	10.6
24	hypogonadotropic hypogonadism 7 with or without anosmia	10.6
25	acromegaly	10.6
26	craniopharyngioma	10.6
27	developmental dysplasia of the hip 1	10.5
28	prader-willi syndrome	10.5
29	papillon-lefevre syndrome	10.5
30	otopalatodigital syndrome, type ii	10.5
31	otopalatodigital syndrome, type i	10.5
32	chromosome 16p13.3 deletion syndrome, proximal	10.5
33	scoliosis	10.5
34	cerebral palsy	10.5
35	ankylosis	10.5
36	pseudohypoparathyroidism	10.5
37	septic arthritis	10.5
38	pik3ca-related overgrowth spectrum	10.5
39	47 xxx syndrome	10.5
40	49, xxxxy syndrome	10.5
41	pituitary tumors	10.5
42	pik3ca-related overgrowth syndrome	10.5
43	avascular necrosis	10.5
44	slipped femoral capital epiphyses	10.4
45	intracranial hypertension, idiopathic	10.4
46	body mass index quantitative trait locus 11	10.4
47	body mass index quantitative trait locus 9	10.4
48	body mass index quantitative trait locus 8	10.4
49	sickle cell anemia	10.4
50	bone mineral density quantitative trait locus 3	10.4

Graphical network of the top 20 diseases related to Epiphysiolysis of the Hip:

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Symptoms & Phenotypes for Epiphysiolysis of the Hip

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Drugs & Therapeutics for Epiphysiolysis of the Hip

Drugs for Epiphysiolysis of the Hip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Sodium Chloride Symporter Inhibitors		Phase 4
2	diuretics		Phase 4
3	Gentamicins		Phase 4

Interventional clinical trials:

(show all 17)

#	Name	Status	NCT ID	Phase
1	A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon	Completed	NCT00208442	Phase 4
2	A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA)	Completed	NCT00872066	Phase 4
3	Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle™ Acetabular Cup Prosthesis With a Ceramic-on-ceramic Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement	Terminated	NCT00872222	Phase 4
4	Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease	Terminated	NCT00873444	Phase 4
5	Prospective, Uncontrolled, Multi-Centre, Post-Marketing Surveillance Study to Evaluate the Long-Term Performance of Summit Tapered Hip in Cementless Total Hip Arthroplasty	Terminated	NCT00208390	Phase 4
6	Prospective Multi-Centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-Term Performance of the DePuy ASR Hip System in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty	Terminated	NCT00208377	Phase 4
7	Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup Prosthesis With a Metal on Metal Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement	Terminated	NCT00208364	Phase 4
8	Prospective Single-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of the DePuy ASR™ Hip in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty	Terminated	NCT00872794	Phase 4
9	Prospective, International Multi-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of a Large Metal-on-Metal (MoM) Bearing Comprising a DePuy ASR™ Cup in Conjunction With Either a DePuy ASR™ Hip Resurfacing Femoral Component or a DePuy ASR™ XL Head in Subjects With Indications Suitable for Either a Primary Resurfacing Arthroplasty or Primary Total Hip Arthroplasty	Terminated	NCT00872547	Phase 4
10	Prospective, Uncontrolled, Two-centre, RSA, Post-market Surveillance Study to Evaluate the Stability of the C-Stem™ AMT Femoral Component in Primary Total Hip Arthroplasty.	Terminated	NCT00872573	Phase 4
11	Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup System With a Metal on Enduron Polyethylene Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement	Withdrawn	NCT00208429	Phase 4
12	Clinical and Radiographic Evaluation to Compare a Polished and Non-polished Collared Stem and a Polished and Non Polished Collarless Stem in Primary Total Hip Replacement	Terminated	NCT00208351	Phase 3
13	A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement	Terminated	NCT00208468	Phase 3
14	Slipped Capital Femoral Epiphysis; Changes in Gait, Balance and Muscle Activity Patterns in Patients Treated With Single Screw in Situ Fixation Investigated Using Computer Assisted Rehabilitation ENvironment (CAREN)	Unknown status	NCT03326531
15	Safe Surgical Dislocation in Slipped Capital Femoral Epiphysis	Unknown status	NCT03229590
16	Skeletal Age Assessment From the Olecranon For Slipped Capital Femoral Epiphysis	Unknown status	NCT01220882
17	SLIP Registry - SCFE Longitudinal International Prospective Registry	Recruiting	NCT04117841

Search NIH Clinical Center for Epiphysiolysis of the Hip

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Genetic Tests for Epiphysiolysis of the Hip

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Anatomical Context for Epiphysiolysis of the Hip

Organs/tissues related to Epiphysiolysis of the Hip:

MalaCards : Bone, Pituitary, Bone Marrow, Thyroid, Tongue, Eye, Kidney

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Publications for Epiphysiolysis of the Hip

Articles related to Epiphysiolysis of the Hip:

(show top 50) (show all 1897)

#	Title	Authors	PMID	Year
1	Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis. ⁶²	Jaber A...Hagmann S	35802155	2022
2	Skeletal Outcomes in Children and Young Adults with Glomerular Disease. ⁶²	Goodwin Davies AJ...Denburg MR	36171052	2022
3	Erratum zu: Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis. ⁶²	Jaber A...Hagmann S	35948650	2022
4	Presence and magnitude of anterior physeal separation in slipped upper femoral epiphysis helps identifying those at high risk for avascular necrosis. ⁶²	Tucker A...Ballard J	36307269	2022
5	A review of slipped capital femoral epiphysis. ⁶²	Cotton EV...Maday KR	36412940	2022
6	Early Total Hip Arthroplasty is a Cost-Effective Treatment for Severe Radiographic Slipped Capital Femoral Epiphysis Over an Individual's Lifetime. ⁶²	de Araujo OB...Vergun AD	36470363	2022
7	Avascular Necrosis and Time to Surgery for Unstable Slipped Capital Femoral Epiphysis: A Systematic Review and Meta-analysis. ⁶²	Ibrahim T...Kenawey M	35941089	2022
8	Limited Hip Flexion and Internal Rotation Resulting From Early Hip Impingement Conflict on Anterior Metaphysis of Patients With Untreated Severe SCFE Using 3D Modelling. ⁶²	Lerch TD...Novais EN	36099440	2022
9	The Utility of Virtual Reality in Orthopedic Surgical Training. ⁶²	Cevallos N...Thompson RM	35821110	2022
10	Characterizing the Residual SCFE Deformity: Utility of the 45-degree Dunn View. ⁶²	Smith CA...Nepple JJ	36037440	2022
11	Modified Dunn procedure versus percutaneous pinning in moderate/severe stable slipped capital femoral epiphyses. ⁶²	Galletta C...Masse A	33829904	2022
12	Quality of YouTube videos for three common pediatric hip conditions: developmental hip dysplasia, slipped capital femoral epiphysis and Legg-Calve-Perthes disease. ⁶²	Lock AM...Baker JF	35357371	2022
13	Physical disability in Late Antiquity Milan: slipped capital femoral epiphysis with severe secondary joint disease in the Basilica of San Dionigi. ⁶²	Biehler-Gomez L...Cattaneo C	36218258	2022
14	Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression. ⁶²	Wadstrom MG...Hailer YD	36288602	2022
15	Clinical and radiological outcomes following surgical hip dislocation for paediatric hip pathologies, a prospective cohort study. ⁶²	Ahern S...Green C	36307306	2022
16	Readability of online patient educational materials for common orthopaedic paediatric conditions within Australasia. ⁶²	Lock AM...Baker JF	36221204	2022
17	Avascular Necrosis After Modified Dunn Surgery for the Treatment of Slipped Capital Femoral Epiphysis. ⁶²	Valenza W...Faggion H	36226215	2022
18	Outcomes in Pediatric Hip FAI Surgery: a Scoping Review. ⁶²	Alvandi BA...Tjong VK	35917094	2022
19	Risk of Avascular Necrosis with The Modified Dunn Procedure in SCFE Patients: A Meta-Analysis. ⁶²	Jauregui JJ...McClure PK	36360408	2022
20	Unusual Age of Presentation and Etiology of Slipped Capital Femoral Epiphysis Following a Seizure Attack: A Case Report. ⁶²	Kaneetah AH...Alansari AO	36465788	2022
21	Increasing incidence of slipped capital femoral epiphysis in Trinidad and Tobago: A 50-year review. ⁶²	Beharry AC...Thomas D	36214270	2022
22	Prospective evaluation of in situ screw fixation for stable slipped capital femoral epiphysis. ⁶²	DeVries CA...Upasani VV	36238141	2022
23	Hardware Impingement Is Associated With Shorter Screw Length in Patients Treated With In Situ Screw Fixation for Slipped Capital Femoral Epiphysis: An In Vivo Arthroscopic Evaluation. ⁶²	Lewis DC...Aoki SK	36312729	2022
24	Prevalence of Avascular Necrosis Following Surgical Treatments in Unstable Slipped Capital Femoral Epiphysis (SCFE): A Systematic Review and Meta-Analysis. ⁶²	Veramuthu V...Sulaiman AR	36138683	2022
25	The contralateral hip in slipped capital femoral epiphysis: Is there an easy-to-use algorithm to support a decision for prophylactic fixation? ⁶²	Lindell M...Herngren B	35992523	2022
26	Screw Thread Configuration Has No Effect on Outcomes of In Situ Fixation for Stable Slipped Capital Femoral Epiphysis. ⁶²	Via GG...Albert MC	35671226	2022
27	Are children with obesity at school entry more likely to have a diagnosis of a musculoskeletal condition? Findings from a systematic review. ⁶²	Firman N...Dezateux C	36053659	2022
28	Development and Validation of SCFE Percutaneous Pinning Surgical Simulation. ⁶²	Ikwuezunma IA...Margalit A	35319527	2022
29	Long-term follow up of 44 cats undergoing total hip replacement: Cases from a feline hip registry (2010-2020). ⁶²	Rodino Tilve V...Comerford E	35642440	2022
30	Is there a persistent capital femoral epiphysis growth after screw fixation for slipped capital femoral epiphysis? ⁶²	Sleth C...Delpont M	35854809	2022
31	Controlled repositioning and primary osteoplasty as a treatment option for the management of unstable slipped capital femoral epiphysis. ⁶²	Venkatadass K...Rajasekaran S	35620839	2022
32	A Retrospective Study of Risk Factors and Outcomes in the Surgical Management of Slipped Capital Femoral Epiphysis. ⁶²	Jin W...Mulpuri K	35794815	2022
33	Is the level of vitamin D deficiency correlated with the severity and bilaterality in slipped capital femoral epiphysis? A case series study. ⁶²	Elbeshry S...Mahmoud S	36001825	2022
34	Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a 12-Year-Old With Slipped Capital Femoral Epiphysis. ⁶²	Vitale RJ...Gordon RJ	35592510	2022
35	Central precocious puberty with hypothalamic hamartoma; the first case reports of two siblings with different phenotypes in Seckel syndrome 5. ⁶²	Park J...Lee J	35798296	2022
36	Identification of musculoskeletal problems using pGALS examination in school going boys in Chennai, India. ⁶²	Bhaskar N...Janarthanan M	36119161	2022
37	Slipped upper femoral epiphysis: An important cause of paediatric hip pain. ⁶²	Truong A...Wall C	35637586	2022
38	Telescoping screw fixation compared to traditional in situ screw fixation for slipped capital femoral epiphysis: clinical, radiographic and patient-reported outcomes. ⁶²	Hansen CH...Upasani VV	34050119	2022
39	Risk factors for early symptomatic femoroacetabular impingement following in situ fixation of slipped capital femoral epiphysis. ⁶²	Allen MM...Rosenfeld SB	35462635	2022
40	Minimal Out-Toeing and Good Hip Scores of Severe SCFE Patients Treated With Modified Dunn Procedure and Contralateral Prophylactic Pinning at Minimal 5-year Follow up. ⁶²	Lerch TD...Ziebarth K	35250015	2022
41	Outcomes and Survivorship at a Median of 8.9 Years Following Hip Arthroscopy in Adolescents with Femoroacetabular Impingement: A Matched Comparative Study with Adults. ⁶²	Fukase N...Philippon MJ	35255011	2022
42	Prophylactic fixation of the unaffected contralateral side in children with slipped capital femoral epiphysis seems favorable: A systematic review. ⁶²	Vink SJC...van Bergen CJA	35633749	2022
43	Proximal femoral changes related to obesity: an analysis of slipped capital femoral epiphysis pathoanatomy. ⁶²	Winston TW...Hosseinzadeh P	33720077	2022
44	Factors Affecting Slip Progression After In Situ Screw Fixation of Stable Slipped Capital Femoral Epiphysis. ⁶²	Makarewich CA...MacWilliams BA	35200211	2022
45	Slipped Capital Femoral Epiphysis Associated With Athletic Activity. ⁶²	Loder RT...Novais EV	35502132	2022
46	Comparing complications of outpatient management of slipped capital femoral epiphysis and Blount's disease: A database study. ⁶²	Jardaly A...Gilbert SR	35582157	2022
47	The British Orthopaedic Surgery Surveillance study: slipped capital femoral epiphysis: the epidemiology and two-year outcomes from a prospective cohort in Great Britain. ⁶²	Perry DC...BOSS collaborators	35360942	2022
48	Xanthomatous hypophysitis causing hypogonadotropic hypogonadism resulting in delayed presentation of slipped capital femoral epiphysis. ⁶²	Singh K...Hossain-Ibrahim K	30450996	2022
49	Evaluation of a Slipped Capital Femoral Epiphysis Virtual Reality Surgical Simulation for the Orthopaedic Trainee. ⁶²	Margalit A...Laporte D	35467580	2022
50	Hypothyroidism Presenting as Slipped Capital Femoral Epiphysis. ⁶²	Manglunia A...Mangaraj S	35218254	2022

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Genes for Epiphysiolysis of the Hip

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Variations for Epiphysiolysis of the Hip

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Expression for Epiphysiolysis of the Hip

Search GEO for disease gene expression data for Epiphysiolysis of the Hip.

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Pathways for Epiphysiolysis of the Hip

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GO Terms for Epiphysiolysis of the Hip

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Sources for Epiphysiolysis of the Hip

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SCFE MCID: EPP010 MIFTS: 30	Epiphysiolysis of the Hip (SCFE) Categories: Bone diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Tissues Related diseases Publications Drugs Expand all tables

Epiphysiolysis of the Hip (SCFE)

Aliases & Classifications for Epiphysiolysis of the Hip

MalaCards integrated aliases for Epiphysiolysis of the Hip:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Epiphysiolysis of the Hip

Related Diseases for Epiphysiolysis of the Hip

Diseases related to Epiphysiolysis of the Hip via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Epiphysiolysis of the Hip:

Symptoms & Phenotypes for Epiphysiolysis of the Hip

Drugs & Therapeutics for Epiphysiolysis of the Hip

Drugs for Epiphysiolysis of the Hip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Epiphysiolysis of the Hip

Anatomical Context for Epiphysiolysis of the Hip

Organs/tissues related to Epiphysiolysis of the Hip:

Publications for Epiphysiolysis of the Hip

Articles related to Epiphysiolysis of the Hip:

Genes for Epiphysiolysis of the Hip

Variations for Epiphysiolysis of the Hip

Expression for Epiphysiolysis of the Hip

Pathways for Epiphysiolysis of the Hip

GO Terms for Epiphysiolysis of the Hip

Sources for Epiphysiolysis of the Hip