MCID: EPS038
MIFTS: 18

Episodic Angioedema with Eosinophilia

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Episodic Angioedema with Eosinophilia

MalaCards integrated aliases for Episodic Angioedema with Eosinophilia:

Name: Episodic Angioedema with Eosinophilia 20
Gleich Syndrome 20

Classifications:



Summaries for Episodic Angioedema with Eosinophilia

GARD : 20 Episodic angioedema with eosinophilia is a disorder characterized by episodes of swelling under the skin (angioedema) and an elevated number of the white blood cells known as eosinophils (eosinophilia). During these episodes, symptoms of hives ( urticaria ), fever, swelling, weight gain and eosinophilia may occur. Symptoms usually appear every 3-4 weeks and resolve on their own within several days. Other cells may be elevated during the episodes, such as neutrophils and lymphocytes. Although the syndrome is often considered a subtype of the idiopathic hypereosinophilic syndromes, it does not typically have organ involvement or lead to other health concerns. The cause of this condition is unknown. Treatment may not be needed, but can involve the use of steroids.

MalaCards based summary : Episodic Angioedema with Eosinophilia, also known as gleich syndrome, is related to angioedema and hypereosinophilic syndrome. An important gene associated with Episodic Angioedema with Eosinophilia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response NFAT in immune response. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder.

Wikipedia : 73 Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated... more...

Related Diseases for Episodic Angioedema with Eosinophilia

Diseases related to Episodic Angioedema with Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 angioedema 10.7
2 hypereosinophilic syndrome 10.7
3 urticaria 10.3
4 cytokine deficiency 10.3
5 erythema multiforme 10.1
6 exanthem 10.1
7 primary biliary cholangitis 10.1
8 capillary leak syndrome 10.1
9 enthesopathy 10.1
10 connective tissue disease 10.1
11 myocarditis 10.1
12 influenza 10.1
13 collagen disease 10.1
14 cholangitis 10.1
15 eosinophilia-myalgia syndrome 10.1
16 immunoglobulin g deficiency 9.7 IGHE CD40LG
17 ocular toxoplasmosis 9.7 IGHE CD40LG
18 eosinophilic meningitis 9.7 IGHE CD40LG
19 immunodeficiency with hyper-igm, type 1 9.7 IGHE CD40LG
20 schistosomiasis 9.6 IGHE CD40LG
21 omenn syndrome 9.6 IGHE CD40LG
22 asthma 9.5 IGHE CD40LG

Graphical network of the top 20 diseases related to Episodic Angioedema with Eosinophilia:



Diseases related to Episodic Angioedema with Eosinophilia

Symptoms & Phenotypes for Episodic Angioedema with Eosinophilia

Drugs & Therapeutics for Episodic Angioedema with Eosinophilia

Drugs for Episodic Angioedema with Eosinophilia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 2
2 Antibodies Phase 2
3 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Mepolizumab in Episodic Angioedema With Eosinophilia Recruiting NCT04128371 Phase 2

Search NIH Clinical Center for Episodic Angioedema with Eosinophilia

Genetic Tests for Episodic Angioedema with Eosinophilia

Anatomical Context for Episodic Angioedema with Eosinophilia

Publications for Episodic Angioedema with Eosinophilia

Articles related to Episodic Angioedema with Eosinophilia:

(show all 36)
# Title Authors PMID Year
1
Episodic angioedema associated with eosinophilia. 20
28954105 2017
2
A case of episodic angioedema with eosinophilia in an elderly woman with primary biliary cholangitis. 61
33751419 2021
3
Successful Long-Term Control of the Syndrome of Episodic Angioedema With Eosinophilia (Gleich Syndrome) With Low-Dose Imatinib Mesylate and Prednisone. 61
33459036 2021
4
Gleich syndrome: a systematic review. 61
32557651 2020
5
Episodic angioedema with eosinophilia (Gleich syndrome) in children: A clinical review. 61
31725177 2020
6
Non-episodic Angioedema With Eosinophilia Successfully Treated With Reslizumab. 61
32009329 2020
7
Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis. 61
30738125 2019
8
A case of non-episodic angioedema with eosinophilia induced by influenza vaccine. 61
28943505 2017
9
Histological Classification and Differential Diagnosis of Nonepisodic Angioedema With Eosinophilia: A Clinicopathologic Study of 12 Cases With Literature Review. 61
26709973 2016
10
Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder. 61
25527564 2015
11
Serum TARC levels correlate with disease activity in patients with non-episodic angioedema with eosinophilia. 61
25156873 2014
12
Olanzapine-induced limb edema simulating episodic angioedema with eosinophilia. 61
22452653 2012
13
A 44-year-old man with bilateral eyelid swelling. 61
22525399 2012
14
[Episodic angioedema with eosinophilia]. 61
21617356 2011
15
Non-episodic angioedema associated with eosinophilia following Mycoplasma pneumoniae infection. 61
18704545 2008
16
Episodic angioedema with eosinophilia: successful treatment with imatinib. 61
18320923 2008
17
Cyclical hypereosinophilia with skin manifestations and a clonal T cell population. 61
18973106 2008
18
A case report of nonepisodic angioedema with eosinophilia in a Korean patient and a review of the Korean literature. 61
17249513 2006
19
Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). 61
17085290 2006
20
[Recurrent angioedema and hypereosinophilia]. 61
15946631 2005
21
[Gleich syndrome. A case report and review of the literature]. 61
15710260 2005
22
Observations on edema formation and resolution in Gleich syndrome: essential role of the kidneys in effective arterial blood volume regulation. 61
11359025 2001
23
The cytokine profile in a transient variant of angioedema with eosinophilia. 61
11167701 2001
24
[Two cases of episodic angioedema associated with eosinophilia]. 61
11218318 2001
25
[Gleich's syndrome]. 61
10930860 2000
26
[Recurrent angioedema with gastroenteritis in blood and tissue eosinophilia]. 61
9715385 1998
27
Increased interleukin-6 production during the acute phase of the syndrome of episodic angioedema and hypereosinophilia. 61
9641577 1998
28
[Episodic angioedema with eosinophilia]. 61
8492460 1993
29
Episodic angioedema with eosinophilia: a case associated with T cell activation and cytokine production. 61
8452319 1993
30
[Episodic angioedema with eosinophilia]. 61
8436312 1993
31
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. 61
1583248 1992
32
Four Japanese cases of episodic angioedema with eosinophilia. 61
1633350 1992
33
Episodic angioedema with eosinophilia: precursor lesions and relevance of histology. A case report. 61
1676228 1991
34
Episodic angioedema with eosinophilia (Gleich syndrome). 61
2148252 1990
35
Episodic angioedema with eosinophilia. 61
2521494 1989
36
Facial edema and eosinophilia. Evidence for eosinophil degranulation. 61
3898950 1985

Variations for Episodic Angioedema with Eosinophilia

Expression for Episodic Angioedema with Eosinophilia

Search GEO for disease gene expression data for Episodic Angioedema with Eosinophilia.

Pathways for Episodic Angioedema with Eosinophilia

Pathways related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 IGHE CD40LG
2
Show member pathways
11.51 IGHE CD40LG
3 10.42 IGHE CD40LG

GO Terms for Episodic Angioedema with Eosinophilia

Cellular components related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 IGHE CD40LG

Biological processes related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.62 IGHE CD40LG

Sources for Episodic Angioedema with Eosinophilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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