MCID: EPS038
MIFTS: 17

Episodic Angioedema with Eosinophilia

Categories: Rare diseases

Aliases & Classifications for Episodic Angioedema with Eosinophilia

MalaCards integrated aliases for Episodic Angioedema with Eosinophilia:

Name: Episodic Angioedema with Eosinophilia 53
Gleich Syndrome 53

Classifications:



Summaries for Episodic Angioedema with Eosinophilia

NIH Rare Diseases : 53 Episodic angioedema with eosinophilia is a disorder characterized by episodes of swelling under the skin (angioedema) and an elevated number of the white blood cells known as eosinophils (eosinophilia). During these episodes, symptoms of hives (urticaria), fever, swelling, weight gain and eosinophilia may occur. Symptoms usually appear every 3-4 weeks and resolve on their own within several days. Other cells may be elevated during the episodes, such as neutrophils and lymphocytes. Although the syndrome is often considered a subtype of the idiopathic hypereosinophilic syndromes, it does not typically have organ involvement or lead to other health concerns. The cause of this condition is unknown. Treatment may not be needed, but can involve the use of steroids. 

MalaCards based summary : Episodic Angioedema with Eosinophilia, also known as gleich syndrome, is related to angioedema and influenza. An important gene associated with Episodic Angioedema with Eosinophilia is CD40LG (CD40 Ligand), and among its related pathways/superpathways is IL4-mediated signaling events. Affiliated tissues include neutrophil and skin.

Wikipedia : 76 Gleich\'s syndrome or episodic angioedema with eosinophilia is a rare disease in which the body swells... more...

Related Diseases for Episodic Angioedema with Eosinophilia

Diseases related to Episodic Angioedema with Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 angioedema 10.3
2 influenza 9.9
3 eosinophilia-myalgia syndrome 9.9
4 immunoglobulin g deficiency 9.6 CD40LG IGHE
5 toxocariasis 9.6 CD40LG IGHE
6 ocular toxoplasmosis 9.6 CD40LG IGHE
7 immunodeficiency with hyper-igm, type 1 9.5 CD40LG IGHE
8 vernal conjunctivitis 9.5 CD40LG IGHE
9 schistosomiasis 9.4 CD40LG IGHE
10 bronchiolitis 9.3 CD40LG IGHE
11 otitis media 9.2 CD40LG IGHE
12 asthma 9.0 CD40LG IGHE

Graphical network of the top 20 diseases related to Episodic Angioedema with Eosinophilia:



Diseases related to Episodic Angioedema with Eosinophilia

Symptoms & Phenotypes for Episodic Angioedema with Eosinophilia

Drugs & Therapeutics for Episodic Angioedema with Eosinophilia

Search Clinical Trials , NIH Clinical Center for Episodic Angioedema with Eosinophilia

Genetic Tests for Episodic Angioedema with Eosinophilia

Anatomical Context for Episodic Angioedema with Eosinophilia

MalaCards organs/tissues related to Episodic Angioedema with Eosinophilia:

41
Neutrophil, Skin

Publications for Episodic Angioedema with Eosinophilia

Articles related to Episodic Angioedema with Eosinophilia:

# Title Authors Year
1
A case of non-episodic angioedema with eosinophilia induced by influenza vaccine. ( 28943505 )
2017
2
Olanzapine-induced limb edema simulating episodic angioedema with eosinophilia. ( 22452653 )
2012
3
Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). ( 17085290 )
2006
4
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. ( 1583248 )
1992
5
Episodic angioedema with eosinophilia (Gleich syndrome). ( 2148252 )
1990

Variations for Episodic Angioedema with Eosinophilia

Expression for Episodic Angioedema with Eosinophilia

Search GEO for disease gene expression data for Episodic Angioedema with Eosinophilia.

Pathways for Episodic Angioedema with Eosinophilia

Pathways related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 CD40LG IGHE

GO Terms for Episodic Angioedema with Eosinophilia

Cellular components related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG IGHE

Biological processes related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.62 CD40LG IGHE

Sources for Episodic Angioedema with Eosinophilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....