MCID: EPS038
MIFTS: 20

Episodic Angioedema with Eosinophilia

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Episodic Angioedema with Eosinophilia

MalaCards integrated aliases for Episodic Angioedema with Eosinophilia:

Name: Episodic Angioedema with Eosinophilia 54
Gleich Syndrome 54

Classifications:



Summaries for Episodic Angioedema with Eosinophilia

NIH Rare Diseases : 54 Episodic angioedema with eosinophilia is a disorder characterized by episodes of swelling under the skin (angioedema) and an elevated number of the white blood cells known as eosinophils (eosinophilia). During these episodes, symptoms of hives (urticaria), fever, swelling, weight gain and eosinophilia may occur. Symptoms usually appear every 3-4 weeks and resolve on their own within several days. Other cells may be elevated during the episodes, such as neutrophils and lymphocytes. Although the syndrome is often considered a subtype of the idiopathic hypereosinophilic syndromes, it does not typically have organ involvement or lead to other health concerns. The cause of this condition is unknown. Treatment may not be needed, but can involve the use of steroids. 

MalaCards based summary : Episodic Angioedema with Eosinophilia, also known as gleich syndrome, is related to angioedema and hypereosinophilic syndrome. An important gene associated with Episodic Angioedema with Eosinophilia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response NFAT in immune response. Affiliated tissues include skin, neutrophil and kidney.

Wikipedia : 77 Gleich''s syndrome is a rare disease in which the body swells up episodically (angioedema), associated... more...

Related Diseases for Episodic Angioedema with Eosinophilia

Diseases related to Episodic Angioedema with Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 angioedema 10.6
2 hypereosinophilic syndrome 10.4
3 influenza 10.0
4 eosinophilia-myalgia syndrome 10.0
5 immunoglobulin g deficiency 9.7 CD40LG IGHE
6 ocular toxoplasmosis 9.7 CD40LG IGHE
7 immunodeficiency with hyper-igm, type 1 9.7 CD40LG IGHE
8 schistosomiasis 9.6 CD40LG IGHE
9 asthma 9.5 CD40LG IGHE

Graphical network of the top 20 diseases related to Episodic Angioedema with Eosinophilia:



Diseases related to Episodic Angioedema with Eosinophilia

Symptoms & Phenotypes for Episodic Angioedema with Eosinophilia

Drugs & Therapeutics for Episodic Angioedema with Eosinophilia

Search Clinical Trials , NIH Clinical Center for Episodic Angioedema with Eosinophilia

Genetic Tests for Episodic Angioedema with Eosinophilia

Anatomical Context for Episodic Angioedema with Eosinophilia

MalaCards organs/tissues related to Episodic Angioedema with Eosinophilia:

42
Skin, Neutrophil, Kidney, T Cells

Publications for Episodic Angioedema with Eosinophilia

Articles related to Episodic Angioedema with Eosinophilia:

(show all 13)
# Title Authors Year
1
A case of non-episodic angioedema with eosinophilia induced by influenza vaccine. ( 28943505 )
2017
2
Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder. ( 25527564 )
2015
3
Serum TARC levels correlate with disease activity in patients with non-episodic angioedema with eosinophilia. ( 25156873 )
2014
4
Olanzapine-induced limb edema simulating episodic angioedema with eosinophilia. ( 22452653 )
2012
5
Episodic angioedema with eosinophilia: successful treatment with imatinib. ( 18320923 )
2008
6
Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). ( 17085290 )
2006
7
Observations on edema formation and resolution in Gleich syndrome: essential role of the kidneys in effective arterial blood volume regulation. ( 11359025 )
2001
8
Episodic angioedema with eosinophilia: a case associated with T cell activation and cytokine production. ( 8452319 )
1993
9
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. ( 1583248 )
1992
10
Four Japanese cases of episodic angioedema with eosinophilia. ( 1633350 )
1992
11
Episodic angioedema with eosinophilia: precursor lesions and relevance of histology. A case report. ( 1676228 )
1991
12
Episodic angioedema with eosinophilia (Gleich syndrome). ( 2148252 )
1990
13
Episodic angioedema with eosinophilia. ( 2521494 )
1989

Variations for Episodic Angioedema with Eosinophilia

Expression for Episodic Angioedema with Eosinophilia

Search GEO for disease gene expression data for Episodic Angioedema with Eosinophilia.

Pathways for Episodic Angioedema with Eosinophilia

Pathways related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 CD40LG IGHE
2
Show member pathways
11.51 CD40LG IGHE
3 10.42 CD40LG IGHE

GO Terms for Episodic Angioedema with Eosinophilia

Cellular components related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG IGHE

Biological processes related to Episodic Angioedema with Eosinophilia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.62 CD40LG IGHE

Sources for Episodic Angioedema with Eosinophilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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