Epithelial and Subepithelial Dystrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Epithelial and Subepithelial Dystrophy

MalaCards integrated aliases for Epithelial and Subepithelial Dystrophy:

Name: Epithelial and Subepithelial Dystrophy ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060440

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Summaries for Epithelial and Subepithelial Dystrophy

Disease Ontology : ¹² A corneal dystrophy that primarily affects the corneal epithelium and its basement membrane.

MalaCards based summary : Epithelial and Subepithelial Dystrophy is related to corneal degeneration and lattice corneal dystrophy. An important gene associated with Epithelial and Subepithelial Dystrophy is TACSTD2 (Tumor Associated Calcium Signal Transducer 2), and among its related pathways/superpathways is Adhesion. Affiliated tissues include eye.

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Related Diseases for Epithelial and Subepithelial Dystrophy

Diseases related to Epithelial and Subepithelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)

#	Related Disease	Score	Top Affiliating Genes
1	corneal degeneration	10.2	TGFBI KRT12
2	lattice corneal dystrophy	10.1	TGFBI TACSTD2
3	limbal stem cell deficiency	10.0	KRT3 KRT12
4	corneal dystrophy, reis-bucklers type	9.8	TGFBI TBCD TACSTD2
5	tyrosinemia, type ii	9.7	KRT12 CHST6
6	astigmatism	9.7	KRT3 KRT12
7	stromal dystrophy	9.5	TGFBI CHST6
8	macular dystrophy, corneal	9.5	TGFBI KRT12 CHST6
9	epithelial basement membrane dystrophy	9.5	TGFBI TBCD PLEC
10	corneal dystrophy, avellino type	9.3	TGFBI TBCD CHST6
11	corneal dystrophy, gelatinous drop-like	9.2	TGFBI TACSTD2 KRT12 CHST6
12	corneal dystrophy, meesmann	9.1	TGFBI KRT3 KRT12 CHST6
13	corneal endothelial dystrophy	9.1	TGFBI KRT3 KRT12 CHST6
14	corneal dystrophy	8.8	TGFBI TACSTD2 KRT3 KRT12 CHST6
15	corneal disease	8.8	TGFBI TACSTD2 KRT3 KRT12 CHST6
16	epithelial-stromal tgfbi dystrophy	8.8	TGFBI TBCD TACSTD2 KRT12 CHST6
17	corneal dystrophy, thiel-behnke type	8.4	TGFBI TBCD TACSTD2 KRT3 KRT12 CHST6

Graphical network of the top 20 diseases related to Epithelial and Subepithelial Dystrophy:

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Symptoms & Phenotypes for Epithelial and Subepithelial Dystrophy

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Drugs & Therapeutics for Epithelial and Subepithelial Dystrophy

Search Clinical Trials , NIH Clinical Center for Epithelial and Subepithelial Dystrophy

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Genetic Tests for Epithelial and Subepithelial Dystrophy

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Anatomical Context for Epithelial and Subepithelial Dystrophy

MalaCards organs/tissues related to Epithelial and Subepithelial Dystrophy:

⁴¹

Eye

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Publications for Epithelial and Subepithelial Dystrophy

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Genes for Epithelial and Subepithelial Dystrophy

Genes related to Epithelial and Subepithelial Dystrophy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TACSTD2	Tumor Associated Calcium Signal Transducer 2	Protein Coding	18.68	DISEASES inferred ¹⁵
2	KRT12	Keratin 12	Protein Coding	18.15	DISEASES inferred ¹⁵
3	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	17.72	DISEASES inferred ¹⁵
4	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	17.63	DISEASES inferred ¹⁵
5	KRT3	Keratin 3	Protein Coding	17.5	DISEASES inferred ¹⁵
6	TBCD	Tubulin Folding Cofactor D	Protein Coding	15.83	DISEASES inferred ¹⁵
7	PLEC	Plectin	Protein Coding	15.79	DISEASES inferred ¹⁵
8	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	15.47	DISEASES inferred ¹⁵
9	HAL	Histidine Ammonia-Lyase	Protein Coding	15.2	DISEASES inferred ¹⁵

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Variations for Epithelial and Subepithelial Dystrophy

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Expression for Epithelial and Subepithelial Dystrophy

Search GEO for disease gene expression data for Epithelial and Subepithelial Dystrophy.

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Pathways for Epithelial and Subepithelial Dystrophy

Pathways related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Adhesion ⁴	10.89	TGFBI TACSTD2 PLEC

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GO Terms for Epithelial and Subepithelial Dystrophy

Cellular components related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.55	TGFBI TACSTD2 PLEC KRT3 KRT12
2	lateral plasma membrane	GO:0016328	8.96	TBCD TACSTD2
3	intermediate filament	GO:0005882	8.8	PLEC KRT3 KRT12

Biological processes related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:0007601	9.13	TGFBI TACSTD2 KRT12
2	intermediate filament cytoskeleton organization	GO:0045104	8.62	PLEC KRT3

Molecular functions related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.62	PLEC KRT12

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Sources for Epithelial and Subepithelial Dystrophy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁹ Cosmic

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²⁰ GeneAnalytics

²¹ GeneCards

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²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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⁷⁰ TGDB

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⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia