MCID: EPT023
MIFTS: 15

Epithelial and Subepithelial Dystrophy

Categories: Eye diseases

Aliases & Classifications for Epithelial and Subepithelial Dystrophy

MalaCards integrated aliases for Epithelial and Subepithelial Dystrophy:

Name: Epithelial and Subepithelial Dystrophy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060440

Summaries for Epithelial and Subepithelial Dystrophy

Disease Ontology : 12 A corneal dystrophy that primarily affects the corneal epithelium and its basement membrane.

MalaCards based summary : Epithelial and Subepithelial Dystrophy is related to stromal corneal dystrophy and astigmatism. An important gene associated with Epithelial and Subepithelial Dystrophy is TACSTD2 (Tumor Associated Calcium Signal Transducer 2), and among its related pathways/superpathways is Adhesion. Affiliated tissues include eye.

Related Diseases for Epithelial and Subepithelial Dystrophy

Diseases related to Epithelial and Subepithelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 stromal corneal dystrophy 10.3 UBIAD1 TGFBI
2 astigmatism 10.3 KRT3 KRT12 CRYAA
3 limbal stem cell deficiency 10.2 KRT3 KRT12
4 iris disease 10.2 KRT3 KRT12 CRYAA
5 keratitis, hereditary 10.2 KRT3 KRT12 CRYAA
6 corneal dystrophy, lattice type i 10.2 TGFBI GSN
7 aniridia 1 10.2 KRT3 KRT12 CRYAA
8 metaphyseal chondrodysplasia, schmid type 10.1 CRYAA COL8A2 COL10A1
9 immature cataract 10.1 SLC4A11 CRYAA
10 schnyder corneal dystrophy 10.1 UBIAD1 TGFBI KRT3 KRT12
11 blepharochalasis 10.0 GSN COL8A2
12 secondary corneal edema 10.0 SLC4A11 COL8A2
13 pseudopterygium 10.0 SLC4A11 KRT3 KRT12
14 corneal ectasia 10.0 TGFBI COL8A2
15 corneal dystrophy, posterior polymorphous, 2 9.9 SLC4A11 COL8A2
16 corneal dystrophy, endothelial, x-linked 9.9 SLC4A11 COL8A2
17 corneal dystrophy, lisch epithelial 9.9 UBIAD1 TBCD KRT3 KRT12 CHST6
18 corneal dystrophy, posterior polymorphous, 3 9.8 UBIAD1 SLC4A11 COL8A2
19 corneal dystrophy, band-shaped 9.8 SLC4A11 COL8A2
20 corneal dystrophy, subepithelial mucinous 9.8 TSPAN15 TBCD CRYAA COL10A1
21 amyloidosis, finnish type 9.8 TGFBI GSN
22 corneal dystrophy, fleck 9.7 TGFBI TBCD SLC4A11 COL8A2
23 corneal deposit 9.7 UBIAD1 TGFBI TBCD TACSTD2 KRT3 CHST6
24 recurrent corneal erosion 9.7 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
25 granular corneal dystrophy 9.7 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
26 irregular astigmatism 9.6 TGFBI SLC4A11 KRT3 KRT12 COL8A2
27 macular dystrophy, corneal 9.6 UBIAD1 TGFBI KRT3 KRT12 COL8A2 CHST6
28 corneal edema 9.6 TGFBI SLC4A11 KRT3 KRT12 COL8A2
29 corneal dystrophy, reis-bucklers type 9.6 UBIAD1 TGFBI TBCD TACSTD2 KRT3 KRT12
30 corneal dystrophy, avellino type 9.6 UBIAD1 TGFBI TBCD KRT3 COL8A2 CHST6
31 lattice corneal dystrophy 9.6 TGFBI TBCD TACSTD2 KRT12 GSN CHST6
32 fuchs' endothelial dystrophy 9.5 TGFBI SLC4A11 KRT3 KRT12 COL8A2 CHST6
33 epithelial-stromal tgfbi dystrophy 9.3 TGFBI TBCD KRT3 KRT12 GSN COL8A2
34 corneal dystrophy, thiel-behnke type 9.3 UBIAD1 TGFBI TBCD TACSTD2 KRT3 KRT12
35 keratoconus 9.3 TGFBI SLC4A11 KRT3 KRT12 GSN COL8A2
36 corneal dystrophy, posterior polymorphous, 1 9.2 UBIAD1 TGFBI SLC4A11 KRT3 KRT12 COL8A2
37 corneal degeneration 9.1 UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
38 stromal dystrophy 9.1 UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
39 corneal endothelial dystrophy 9.1 UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
40 corneal dystrophy, meesmann 9.0 UBIAD1 TGFBI TBCD SECTM1 KRT3 KRT12
41 epithelial basement membrane dystrophy 8.9 TMEM263 TGFBI TBCD PLEC LINC00326 FAM9B
42 corneal disease 8.6 UBIAD1 TGFBI TACSTD2 SLC4A11 KRT3 KRT12
43 corneal dystrophy 8.6 UBIAD1 TGFBI TBCD TACSTD2 SLC4A11 KRT3
44 corneal dystrophy, gelatinous drop-like 8.3 UTP14C UBIAD1 TGFBI TBCD TACSTD2 PRCD

Graphical network of the top 20 diseases related to Epithelial and Subepithelial Dystrophy:



Diseases related to Epithelial and Subepithelial Dystrophy

Symptoms & Phenotypes for Epithelial and Subepithelial Dystrophy

Drugs & Therapeutics for Epithelial and Subepithelial Dystrophy

Search Clinical Trials , NIH Clinical Center for Epithelial and Subepithelial Dystrophy

Genetic Tests for Epithelial and Subepithelial Dystrophy

Anatomical Context for Epithelial and Subepithelial Dystrophy

MalaCards organs/tissues related to Epithelial and Subepithelial Dystrophy:

40
Eye

Publications for Epithelial and Subepithelial Dystrophy

Variations for Epithelial and Subepithelial Dystrophy

Expression for Epithelial and Subepithelial Dystrophy

Search GEO for disease gene expression data for Epithelial and Subepithelial Dystrophy.

Pathways for Epithelial and Subepithelial Dystrophy

Pathways related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 TGFBI TACSTD2 PLEC

GO Terms for Epithelial and Subepithelial Dystrophy

Cellular components related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcoplasm GO:0016528 8.62 PLEC GSN

Biological processes related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.02 TGFBI TACSTD2 PRCD KRT12 CRYAA
2 intermediate filament cytoskeleton organization GO:0045104 8.96 PLEC KRT3

Molecular functions related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 TGFBI COL8A2 COL10A1

Sources for Epithelial and Subepithelial Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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