Epithelial and Subepithelial Dystrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Epithelial and Subepithelial Dystrophy

MalaCards integrated aliases for Epithelial and Subepithelial Dystrophy:

Name: Epithelial and Subepithelial Dystrophy ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060440

Sources

Summaries for Epithelial and Subepithelial Dystrophy

Disease Ontology : ¹² A corneal dystrophy that primarily affects the corneal epithelium and its basement membrane.

MalaCards based summary : Epithelial and Subepithelial Dystrophy is related to stromal corneal dystrophy and astigmatism. An important gene associated with Epithelial and Subepithelial Dystrophy is TACSTD2 (Tumor Associated Calcium Signal Transducer 2), and among its related pathways/superpathways is Adhesion. Affiliated tissues include eye.

Sources

Related Diseases for Epithelial and Subepithelial Dystrophy

Diseases related to Epithelial and Subepithelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)

#	Related Disease	Score	Top Affiliating Genes
1	stromal corneal dystrophy	10.3	UBIAD1 TGFBI
2	astigmatism	10.3	KRT3 KRT12 CRYAA
3	limbal stem cell deficiency	10.2	KRT3 KRT12
4	iris disease	10.2	KRT3 KRT12 CRYAA
5	keratitis, hereditary	10.2	KRT3 KRT12 CRYAA
6	corneal dystrophy, lattice type i	10.2	TGFBI GSN
7	aniridia 1	10.2	KRT3 KRT12 CRYAA
8	metaphyseal chondrodysplasia, schmid type	10.1	CRYAA COL8A2 COL10A1
9	immature cataract	10.1	SLC4A11 CRYAA
10	schnyder corneal dystrophy	10.1	UBIAD1 TGFBI KRT3 KRT12
11	blepharochalasis	10.0	GSN COL8A2
12	secondary corneal edema	10.0	SLC4A11 COL8A2
13	pseudopterygium	10.0	SLC4A11 KRT3 KRT12
14	corneal ectasia	10.0	TGFBI COL8A2
15	corneal dystrophy, posterior polymorphous, 2	9.9	SLC4A11 COL8A2
16	corneal dystrophy, endothelial, x-linked	9.9	SLC4A11 COL8A2
17	corneal dystrophy, lisch epithelial	9.9	UBIAD1 TBCD KRT3 KRT12 CHST6
18	corneal dystrophy, posterior polymorphous, 3	9.8	UBIAD1 SLC4A11 COL8A2
19	corneal dystrophy, band-shaped	9.8	SLC4A11 COL8A2
20	corneal dystrophy, subepithelial mucinous	9.8	TSPAN15 TBCD CRYAA COL10A1
21	amyloidosis, finnish type	9.8	TGFBI GSN
22	corneal dystrophy, fleck	9.7	TGFBI TBCD SLC4A11 COL8A2
23	corneal deposit	9.7	UBIAD1 TGFBI TBCD TACSTD2 KRT3 CHST6
24	recurrent corneal erosion	9.7	TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
25	granular corneal dystrophy	9.7	TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
26	irregular astigmatism	9.6	TGFBI SLC4A11 KRT3 KRT12 COL8A2
27	macular dystrophy, corneal	9.6	UBIAD1 TGFBI KRT3 KRT12 COL8A2 CHST6
28	corneal edema	9.6	TGFBI SLC4A11 KRT3 KRT12 COL8A2
29	corneal dystrophy, reis-bucklers type	9.6	UBIAD1 TGFBI TBCD TACSTD2 KRT3 KRT12
30	corneal dystrophy, avellino type	9.6	UBIAD1 TGFBI TBCD KRT3 COL8A2 CHST6
31	lattice corneal dystrophy	9.6	TGFBI TBCD TACSTD2 KRT12 GSN CHST6
32	fuchs' endothelial dystrophy	9.5	TGFBI SLC4A11 KRT3 KRT12 COL8A2 CHST6
33	epithelial-stromal tgfbi dystrophy	9.3	TGFBI TBCD KRT3 KRT12 GSN COL8A2
34	corneal dystrophy, thiel-behnke type	9.3	UBIAD1 TGFBI TBCD TACSTD2 KRT3 KRT12
35	keratoconus	9.3	TGFBI SLC4A11 KRT3 KRT12 GSN COL8A2
36	corneal dystrophy, posterior polymorphous, 1	9.2	UBIAD1 TGFBI SLC4A11 KRT3 KRT12 COL8A2
37	corneal degeneration	9.1	UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
38	stromal dystrophy	9.1	UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
39	corneal endothelial dystrophy	9.1	UBIAD1 TGFBI TBCD SLC4A11 KRT3 KRT12
40	corneal dystrophy, meesmann	9.0	UBIAD1 TGFBI TBCD SECTM1 KRT3 KRT12
41	epithelial basement membrane dystrophy	8.9	TMEM263 TGFBI TBCD PLEC LINC00326 FAM9B
42	corneal disease	8.6	UBIAD1 TGFBI TACSTD2 SLC4A11 KRT3 KRT12
43	corneal dystrophy	8.6	UBIAD1 TGFBI TBCD TACSTD2 SLC4A11 KRT3
44	corneal dystrophy, gelatinous drop-like	8.3	UTP14C UBIAD1 TGFBI TBCD TACSTD2 PRCD

Graphical network of the top 20 diseases related to Epithelial and Subepithelial Dystrophy:

Sources

Symptoms & Phenotypes for Epithelial and Subepithelial Dystrophy

Sources

Drugs & Therapeutics for Epithelial and Subepithelial Dystrophy

Search Clinical Trials , NIH Clinical Center for Epithelial and Subepithelial Dystrophy

Sources

Genetic Tests for Epithelial and Subepithelial Dystrophy

Sources

Anatomical Context for Epithelial and Subepithelial Dystrophy

MalaCards organs/tissues related to Epithelial and Subepithelial Dystrophy:

⁴⁰

Eye

Sources

Publications for Epithelial and Subepithelial Dystrophy

Sources

Genes for Epithelial and Subepithelial Dystrophy

Genes related to Epithelial and Subepithelial Dystrophy (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TACSTD2	Tumor Associated Calcium Signal Transducer 2	Protein Coding	8.59	DISEASES inferred ¹⁵
2	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	8.27	DISEASES inferred ¹⁵
3	KRT12	Keratin 12	Protein Coding	8.16	DISEASES inferred ¹⁵
4	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	7.68	DISEASES inferred ¹⁵
5	KRT3	Keratin 3	Protein Coding	7.67	DISEASES inferred ¹⁵
6	CRYAA	Crystallin Alpha A	Protein Coding	7.32	DISEASES inferred ¹⁵ ¹⁵
7	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	7.08	DISEASES inferred ¹⁵
8	TBCD	Tubulin Folding Cofactor D	Protein Coding	6.92	DISEASES inferred ¹⁵
9	LINC00326	Long Intergenic Non-Protein Coding RNA 326	RNA Gene	6.67	DISEASES inferred ¹⁵
10	UTP14C	UTP14C Small Subunit Processome Component	Protein Coding	6.38	DISEASES inferred ¹⁵
11	UBIAD1	UbiA Prenyltransferase Domain Containing 1	Protein Coding	6.12	DISEASES inferred ¹⁵
12	PLEC	Plectin	Protein Coding	6.09	DISEASES inferred ¹⁵
13	COL8A2	Collagen Type VIII Alpha 2 Chain	Protein Coding	6.05	DISEASES inferred ¹⁵
14	SECTM1	Secreted And Transmembrane 1	Protein Coding	6.04	DISEASES inferred ¹⁵
15	TMEM263	Transmembrane Protein 263	Protein Coding	6	DISEASES inferred ¹⁵
16	GSN	Gelsolin	Protein Coding	5.78	DISEASES inferred ¹⁵
17	SLC4A11	Solute Carrier Family 4 Member 11	Protein Coding	5.61	DISEASES inferred ¹⁵
18	PRCD	Photoreceptor Disc Component	Protein Coding	5.48	DISEASES inferred ¹⁵
19	FAM9B	Family With Sequence Similarity 9 Member B	Protein Coding	5.48	DISEASES inferred ¹⁵
20	TSPAN15	Tetraspanin 15	Protein Coding	5.45	DISEASES inferred ¹⁵

Sources

Variations for Epithelial and Subepithelial Dystrophy

Sources

Expression for Epithelial and Subepithelial Dystrophy

Search GEO for disease gene expression data for Epithelial and Subepithelial Dystrophy.

Sources

Pathways for Epithelial and Subepithelial Dystrophy

Pathways related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Adhesion ⁴	10.89	TGFBI TACSTD2 PLEC

Sources

GO Terms for Epithelial and Subepithelial Dystrophy

Cellular components related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sarcoplasm	GO:0016528	8.62	PLEC GSN

Biological processes related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:0007601	9.02	TGFBI TACSTD2 PRCD KRT12 CRYAA
2	intermediate filament cytoskeleton organization	GO:0045104	8.96	PLEC KRT3

Molecular functions related to Epithelial and Subepithelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	8.8	TGFBI COL8A2 COL10A1

Sources

Sources for Epithelial and Subepithelial Dystrophy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia