MCID: EPT007
MIFTS: 26

Epithelial Malignant Thymoma

Categories: Cancer diseases, Immune diseases, Endocrine diseases, Blood diseases

Aliases & Classifications for Epithelial Malignant Thymoma

MalaCards integrated aliases for Epithelial Malignant Thymoma:

Name: Epithelial Malignant Thymoma 12 15
Well Differentiated Thymic Carcinoma 12
Thymoma, Epithelial 12
Squamoid Thymoma 12
Thymoma, Type B3 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7926
NCIt 50 C7997
SNOMED-CT 68 128715000 128716004
UMLS 73 C0279705

Summaries for Epithelial Malignant Thymoma

MalaCards based summary : Epithelial Malignant Thymoma, also known as well differentiated thymic carcinoma, is related to thymoma and cd45 deficiency. An important gene associated with Epithelial Malignant Thymoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are IL-2 Signaling Pathway and NF-kappa B signaling pathway. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder.

Related Diseases for Epithelial Malignant Thymoma

Diseases related to Epithelial Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 thymoma 28.9 CD5 LCK
2 cd45 deficiency 9.8 CD5 LCK
3 ectopic thymus 9.7 BCL2 CD5
4 thymus cancer 9.7
5 intravascular large b-cell lymphoma 9.7 BCL2 CD5
6 marginal zone b-cell lymphoma 9.6 BCL2 CD5
7 lymphoma, mucosa-associated lymphoid type 9.5 BCL2 CD5
8 spindle cell thymoma 9.3 CD5 CD58 LCK
9 mantle cell lymphoma 9.1 BCL2 CD5
10 dendritic cell thymoma 7.8 BCL2 CD5 CD58 LCK ZBTB33

Graphical network of the top 20 diseases related to Epithelial Malignant Thymoma:



Diseases related to Epithelial Malignant Thymoma

Symptoms & Phenotypes for Epithelial Malignant Thymoma

Drugs & Therapeutics for Epithelial Malignant Thymoma

Drugs for Epithelial Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab in Patients With Type B3 Thymoma and Thymic Carcinoma (NIVOTHYM) Recruiting NCT03134118 Phase 2 Nivolumab
2 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) Recruiting NCT03449173 Phase 2 Sunitinib

Search NIH Clinical Center for Epithelial Malignant Thymoma

Genetic Tests for Epithelial Malignant Thymoma

Anatomical Context for Epithelial Malignant Thymoma

Publications for Epithelial Malignant Thymoma

Articles related to Epithelial Malignant Thymoma:

# Title Authors Year
1
Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. ( 19267104 )
2008
2
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? ( 10047676 )
1999
3
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? ( 10047677 )
1999
4
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. ( 1463094 )
1992
5
Well-differentiated thymic carcinoma: a clinico-pathological study. ( 1549907 )
1992

Variations for Epithelial Malignant Thymoma

Expression for Epithelial Malignant Thymoma

Search GEO for disease gene expression data for Epithelial Malignant Thymoma.

Pathways for Epithelial Malignant Thymoma

Pathways related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 BCL2 LCK
2 10.93 BCL2 LCK
3
Show member pathways
10.45 BCL2 LCK

GO Terms for Epithelial Malignant Thymoma

Biological processes related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell receptor signaling pathway GO:0050853 9.37 BCL2 LCK
2 T cell costimulation GO:0031295 9.32 CD5 LCK
3 hemopoiesis GO:0030097 9.26 BCL2 LCK
4 T cell differentiation GO:0030217 9.16 BCL2 LCK
5 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 8.96 BCL2 LCK
6 cell-cell adhesion GO:0098609 8.8 BCL2 CD58 CTNND1

Molecular functions related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 8.96 BCL2 LCK
2 signaling receptor binding GO:0005102 8.8 CD58 CTNND1 LCK

Sources for Epithelial Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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