MCID: EPT007
MIFTS: 28

Epithelial Malignant Thymoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Epithelial Malignant Thymoma

MalaCards integrated aliases for Epithelial Malignant Thymoma:

Name: Epithelial Malignant Thymoma 12 15
Well Differentiated Thymic Carcinoma 12
Thymoma, Epithelial 12
Squamoid Thymoma 12
Thymoma, Type B3 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7926
NCIt 49 C7997
SNOMED-CT 67 128715000
UMLS 71 C0279705

Summaries for Epithelial Malignant Thymoma

MalaCards based summary : Epithelial Malignant Thymoma, also known as well differentiated thymic carcinoma, is related to cortical thymoma and thymoma. An important gene associated with Epithelial Malignant Thymoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are Tight junction and Amoebiasis. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include thymus, brain and lung.

Related Diseases for Epithelial Malignant Thymoma

Diseases related to Epithelial Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 cortical thymoma 30.5 TTN SRRM1
2 thymoma 29.9 TTN TG CD5 AIRE
3 thymic carcinoma 29.8 TG CD5 CALCA
4 thyrotoxic exophthalmos 10.3 TG CD5
5 papillary thymic adenocarcinoma 10.3 TG CD5
6 endocrine exophthalmos 10.3 TG CD5
7 thyroid gland mucoepidermoid carcinoma 10.3 TG CALCA
8 atypical follicular adenoma 10.3 TG CALCA
9 thymus clear cell carcinoma 10.3 TTN CD5
10 substernal goiter 10.3 TG CALCA
11 thyroid sarcoma 10.3 TG CALCA
12 isthmus cancer 10.3 TG CALCA
13 fetal adenoma 10.3 TG CALCA
14 nonencapsulated sclerosing carcinoma 10.3 TG CALCA
15 acute thyroiditis 10.3 TG CALCA
16 carotid body cancer 10.3 TG CALCA
17 thyroid angiosarcoma 10.2 TG CALCA
18 nasal cavity olfactory neuroblastoma 10.2 TG CALCA
19 papillary thyroid microcarcinoma 10.2 TG CALCA
20 endemic goiter 10.2 TG CALCA
21 uterus leiomyosarcoma 10.2 TG CALCA
22 nontoxic goiter 10.2 TG CALCA
23 graves disease 1 10.2 TG CALCA
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TG AIRE
25 thyroid gland medullary carcinoma 10.2 TG CALCA
26 adrenal cortical hypofunction 10.1 TG AIRE
27 pernicious anemia 10.1 TG AIRE
28 thyroid gland follicular carcinoma 10.1 TG CALCA
29 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CD5 CALCA
30 thymoma, familial 10.1
31 nodular goiter 10.1 TG CALCA
32 ectopic thymus 10.1 TG CD5 CALCA
33 predominantly cortical thymoma 10.1 CD1E AIRE
34 thyroid lymphoma 10.1 TG CD5 CALCA
35 granulomatous orchitis 10.1 CD1E AIRE
36 autoimmune disease of skin and connective tissue 10.1 TG AIRE
37 adrenal cortex disease 10.1 TG AIRE
38 thyroid cancer, nonmedullary, 2 10.0 TG CALCA
39 autoimmune disease of endocrine system 10.0 TG CALCA AIRE
40 parathyroid gland disease 10.0 TG CALCA AIRE
41 hypoadrenocorticism, familial 10.0 TG AIRE
42 myasthenia gravis 10.0
43 verruciform xanthoma of skin 9.9 CD1E CD1A
44 autoimmune polyendocrine syndrome 9.9 TG AIRE
45 chronic laryngitis 9.9 CD1E CD1A
46 aseptic meningitis 9.9 CD58 CALCA
47 multifocal motor neuropathy 9.9 CD1E CD1A
48 hashimoto thyroiditis 9.9 TG CALCA AIRE
49 necrobiosis lipoidica 9.9 CD1E CD1A
50 pityriasis rosea 9.9 CD1E CD1A

Graphical network of the top 20 diseases related to Epithelial Malignant Thymoma:



Diseases related to Epithelial Malignant Thymoma

Symptoms & Phenotypes for Epithelial Malignant Thymoma

Drugs & Therapeutics for Epithelial Malignant Thymoma

Drugs for Epithelial Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-arm, Multicentre, Phase II Study of Immunotherapy in Patients With Type B3 Thymoma and Thymic Carcinoma Previously Treated With Chemotherapy Recruiting NCT03134118 Phase 2 Nivolumab

Search NIH Clinical Center for Epithelial Malignant Thymoma

Genetic Tests for Epithelial Malignant Thymoma

Anatomical Context for Epithelial Malignant Thymoma

MalaCards organs/tissues related to Epithelial Malignant Thymoma:

40
Thymus, Brain, Lung, T Cells

Publications for Epithelial Malignant Thymoma

Articles related to Epithelial Malignant Thymoma:

(show all 39)
# Title Authors PMID Year
1
Ectopic cervical well differentiated thymic carcinoma: report of a diagnostically challenging rare case. 61
30477879 2019
2
AB thymoma with atypical type A component with delayed multiple lung and brain metastases. 61
29221349 2017
3
[Intravenous immunoglobulin therapy in Morvan syndrome secondary to recurrent thymic carcinoma]. 61
26639057 2015
4
[Preoperative spontaneous regression of type B3 thymoma;report of a case]. 61
25743363 2015
5
Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. 61
19267104 2008
6
Thymic tumor with adenoid cystic carcinomalike features: a clinicopathologic study of 4 cases. 61
17667537 2007
7
Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis. 61
17354625 2007
8
Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India. 61
16625962 2006
9
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. 61
17670226 2004
10
Long-term outcome after multimodality treatment for stage III thymic tumors. 61
14667602 2003
11
Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. 61
14602301 2003
12
Clinical and pathologic predictors of survival in patients with thymic tumors. 61
11887069 2002
13
Evidence for distinct mechanisms in the shaping of the CD4 T cell repertoire in histologically distinct myasthenia gravis-associated thymomas. 61
11785677 2001
14
[An analysis of clinicopathologic features affecting prognosis of thymoma]. 61
11783072 2001
15
Prognostic relevance of Masaoka and Müller-Hermelink classification in patients with thymic tumors. 61
10881840 2000
16
Thymic carcinoma--analysis of nineteen clinicopathological studies. 61
11028718 2000
17
Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. 61
10705015 2000
18
Cytology of thymomas: emphasis on morphology and correlation with histologic subtypes. 61
10692213 2000
19
Evaluation of the malignant grade of thymic epithelial tumors according to the epithelial subclassification. 61
10648082 2000
20
[Clinico-pathologic characteristics of malignant thymoma]. 61
11776857 1999
21
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? 61
10047676 1999
22
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? 61
10047677 1999
23
Thymic tumours in Denmark. A retrospective study of 213 cases from 1970-1993. 61
10483587 1999
24
Ki67 labelling index correlates with stage and histology but not significantly with prognosis in thymoma. 61
9839170 1998
25
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. 61
9619646 1998
26
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. 61
9463585 1998
27
Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. 61
9255257 1997
28
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. 61
8543314 1996
29
Recurrent thymoma: evidence for histological progression. 61
8575735 1995
30
Reproducibility of a histogenetic classification of thymic epithelial tumours. 61
7607622 1995
31
The clinicopathological correlation of epithelial subtyping in thymoma: a study of 112 consecutive cases. 61
8088764 1994
32
Thymoma. Histologic subclassification is an independent prognostic factor. 61
8033040 1994
33
Evaluation of a histogenetic classification for thymic epithelial tumours. 61
7959642 1994
34
Distribution of molecules mediating thymocyte-stroma-interactions in human thymus, thymitis and thymic epithelial tumors. 61
7725387 1994
35
Expression of epidermal and nerve growth factor receptors in human thymus and thymomas. 61
8365713 1993
36
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. 61
1463094 1992
37
Well-differentiated thymic carcinoma: a clinico-pathological study. 61
1549907 1992
38
Evaluation of prognostic features in thymic epithelial tumors. 61
2623740 1989
39
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy. 61
2450971 1988

Variations for Epithelial Malignant Thymoma

Expression for Epithelial Malignant Thymoma

Search GEO for disease gene expression data for Epithelial Malignant Thymoma.

Pathways for Epithelial Malignant Thymoma

Pathways related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 CD1E CD1B CD1A
2 11.14 CD1E CD1B CD1A
3 10.92 CD5 CD1E CD1B CD1A

GO Terms for Epithelial Malignant Thymoma

Cellular components related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD5 CD1E CD1B CD1A

Biological processes related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 CD1E CD1B CD1A AIRE
2 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 CD1E CD1B CD1A
3 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.13 CD1E CD1B CD1A
4 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.8 CD1E CD1B CD1A

Molecular functions related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.33 CD1E CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.13 CD1E CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.8 CD1E CD1B CD1A

Sources for Epithelial Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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