MCID: EPT007
MIFTS: 27

Epithelial Malignant Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Epithelial Malignant Thymoma

MalaCards integrated aliases for Epithelial Malignant Thymoma:

Name: Epithelial Malignant Thymoma 12 15
Well Differentiated Thymic Carcinoma 12
Thymoma, Epithelial 12
Squamoid Thymoma 12
Thymoma, Type B3 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7926
NCIt 51 C7997
UMLS 74 C0279705

Summaries for Epithelial Malignant Thymoma

MalaCards based summary : Epithelial Malignant Thymoma, also known as well differentiated thymic carcinoma, is related to thymoma and thymoma, familial. An important gene associated with Epithelial Malignant Thymoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are NF-kappa B signaling pathway and IL2 signaling events mediated by PI3K. The drugs nivolumab and Sunitinib have been mentioned in the context of this disorder.

Related Diseases for Epithelial Malignant Thymoma

Diseases related to Epithelial Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 thymoma 30.3 CD5 LCK
2 thymoma, familial 10.1
3 cd45 deficiency 10.0 CD5 LCK
4 cortical thymoma 9.9
5 ectopic thymus 9.9 BCL2 CD5
6 intravascular large b-cell lymphoma 9.8 BCL2 CD5
7 autoimmune lymphoproliferative syndrome, type v 9.8 BCL2 CD5
8 myasthenia gravis 9.8
9 thymic carcinoma 9.8
10 myasthenia gravis congenital 9.8
11 spindle cell thymoma 9.8 CD5 CD58 LCK
12 marginal zone b-cell lymphoma 9.8 BCL2 CD5
13 lymphoma, mucosa-associated lymphoid type 9.7 BCL2 CD5
14 mantle cell lymphoma 9.6 BCL2 CD5
15 dendritic cell thymoma 9.1 BCL2 CD5 CD58 LCK ZBTB33

Graphical network of the top 20 diseases related to Epithelial Malignant Thymoma:



Diseases related to Epithelial Malignant Thymoma

Symptoms & Phenotypes for Epithelial Malignant Thymoma

Drugs & Therapeutics for Epithelial Malignant Thymoma

Drugs for Epithelial Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
3 Antineoplastic Agents, Immunological Phase 2
4 tyrosine Phase 2
5 Angiogenesis Inhibitors Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab in Patients With Type B3 Thymoma and Thymic Carcinoma (NIVOTHYM) Recruiting NCT03134118 Phase 2 Nivolumab
2 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) Recruiting NCT03449173 Phase 2 Sunitinib

Search NIH Clinical Center for Epithelial Malignant Thymoma

Genetic Tests for Epithelial Malignant Thymoma

Anatomical Context for Epithelial Malignant Thymoma

Publications for Epithelial Malignant Thymoma

Articles related to Epithelial Malignant Thymoma:

# Title Authors Year
1
Ectopic cervical well differentiated thymic carcinoma: report of a diagnostically challenging rare case. ( 30477879 )
2019
2
Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. ( 19267104 )
2008
3
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? ( 10047676 )
1999
4
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? ( 10047677 )
1999
5
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. ( 1463094 )
1992
6
Well-differentiated thymic carcinoma: a clinico-pathological study. ( 1549907 )
1992

Variations for Epithelial Malignant Thymoma

Expression for Epithelial Malignant Thymoma

Search GEO for disease gene expression data for Epithelial Malignant Thymoma.

Pathways for Epithelial Malignant Thymoma

Pathways related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 BCL2 LCK
2
Show member pathways
10.45 BCL2 LCK

GO Terms for Epithelial Malignant Thymoma

Cellular components related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CD5 CD58 CTNND1 LCK STS ZBTB33

Biological processes related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.37 BCL2 STS
2 hemopoiesis GO:0030097 9.32 BCL2 LCK
3 T cell costimulation GO:0031295 9.26 CD5 LCK
4 T cell differentiation GO:0030217 9.16 BCL2 LCK
5 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 8.96 BCL2 LCK
6 cell-cell adhesion GO:0098609 8.8 BCL2 CD58 CTNND1

Molecular functions related to Epithelial Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 8.96 BCL2 LCK
2 signaling receptor binding GO:0005102 8.8 CD58 CTNND1 LCK

Sources for Epithelial Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....