MCID: EPT007
MIFTS: 23

Epithelial Malignant Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Epithelial Malignant Thymoma

MalaCards integrated aliases for Epithelial Malignant Thymoma:

Name: Epithelial Malignant Thymoma 12 15
Well Differentiated Thymic Carcinoma 12
Thymoma, Epithelial 12
Squamoid Thymoma 12
Thymoma, Type B3 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7926
NCIt 49 C7997
UMLS 71 C0279705

Summaries for Epithelial Malignant Thymoma

MalaCards based summary : Epithelial Malignant Thymoma, also known as well differentiated thymic carcinoma, is related to cortical thymoma and thymoma. An important gene associated with Epithelial Malignant Thymoma is CD5 (CD5 Molecule). The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include thyroid, thymus and brain.

Related Diseases for Epithelial Malignant Thymoma

Diseases related to Epithelial Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 cortical thymoma 30.0 TTN SRRM1
2 thymoma 29.7 TTN TG CD5
3 papillary thymic adenocarcinoma 10.3 TG CD5
4 thyrotoxic exophthalmos 10.3 TG CD5
5 endocrine exophthalmos 10.3 TG CD5
6 lymphoepithelioma-like thymic carcinoma 10.3 TG CD5
7 thyroid gland mucoepidermoid carcinoma 10.2 TG CALCA
8 thyroid sarcoma 10.2 TG CALCA
9 acute thyroiditis 10.2 TG CALCA
10 thyroiditis 10.2 TG CALCA
11 fetal adenoma 10.2 TG CALCA
12 nonencapsulated sclerosing carcinoma 10.2 TG CALCA
13 carotid body cancer 10.2 TG CALCA
14 hypoadrenalism 10.2 TG CALCA
15 thyroid angiosarcoma 10.2 TG CALCA
16 nasal cavity olfactory neuroblastoma 10.2 TG CALCA
17 endemic goiter 10.2 TG CALCA
18 papillary thyroid microcarcinoma 10.2 TG CALCA
19 nontoxic goiter 10.1 TG CALCA
20 graves disease 1 10.1 TG CALCA
21 thyroid gland medullary carcinoma 10.1 TG CALCA
22 thyroid gland follicular carcinoma 10.1 TG CALCA
23 thymoma, familial 10.1
24 nodular goiter 10.1 TG CALCA
25 parathyroid gland disease 10.1 TG CALCA
26 aseptic meningitis 10.1 CD58 CALCA
27 autoimmune disease of endocrine system 10.1 TG CALCA
28 spindle epithelial tumor with thymus-like differentiation tumor 10.0 TG CD5 CALCA
29 ectopic thymus 10.0 TG CD5 CALCA
30 thyroid cancer, nonmedullary, 2 10.0 TG CALCA
31 myasthenia gravis 10.0
32 multinodular goiter 10.0 TG CALCA
33 thymus clear cell carcinoma 9.9 TTN CD5
34 thyroid carcinoma, familial medullary 9.8 TG CALCA
35 spindle cell thymoma 9.8
36 thymic carcinoma 9.8
37 thymus gland disease 9.8 TTN CD5
38 thymus cancer 9.8 TTN CD5
39 follicular adenoma 9.7 TG CALCA
40 lymphatic system cancer 9.7 TTN CD5
41 dendritic cell thymoma 9.2 TTN TSR1 SRRM1 CD58 CD5

Graphical network of the top 20 diseases related to Epithelial Malignant Thymoma:



Diseases related to Epithelial Malignant Thymoma

Symptoms & Phenotypes for Epithelial Malignant Thymoma

Drugs & Therapeutics for Epithelial Malignant Thymoma

Drugs for Epithelial Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-arm, Multicentre, Phase II Study of Immunotherapy in Patients With Type B3 Thymoma and Thymic Carcinoma Previously Treated With Chemotherapy Recruiting NCT03134118 Phase 2 Nivolumab

Search NIH Clinical Center for Epithelial Malignant Thymoma

Genetic Tests for Epithelial Malignant Thymoma

Anatomical Context for Epithelial Malignant Thymoma

MalaCards organs/tissues related to Epithelial Malignant Thymoma:

40
Thyroid, Thymus, Brain, Lung, T Cells

Publications for Epithelial Malignant Thymoma

Articles related to Epithelial Malignant Thymoma:

(show all 39)
# Title Authors PMID Year
1
Ectopic cervical well differentiated thymic carcinoma: report of a diagnostically challenging rare case. 61
30477879 2019
2
AB thymoma with atypical type A component with delayed multiple lung and brain metastases. 61
29221349 2017
3
[Intravenous immunoglobulin therapy in Morvan syndrome secondary to recurrent thymic carcinoma]. 61
26639057 2015
4
[Preoperative spontaneous regression of type B3 thymoma;report of a case]. 61
25743363 2015
5
Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. 61
19267104 2008
6
Thymic tumor with adenoid cystic carcinomalike features: a clinicopathologic study of 4 cases. 61
17667537 2007
7
Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis. 61
17354625 2007
8
Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India. 61
16625962 2006
9
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. 61
17670226 2004
10
Long-term outcome after multimodality treatment for stage III thymic tumors. 61
14667602 2003
11
Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. 61
14602301 2003
12
Clinical and pathologic predictors of survival in patients with thymic tumors. 61
11887069 2002
13
Evidence for distinct mechanisms in the shaping of the CD4 T cell repertoire in histologically distinct myasthenia gravis-associated thymomas. 61
11785677 2001
14
[An analysis of clinicopathologic features affecting prognosis of thymoma]. 61
11783072 2001
15
Prognostic relevance of Masaoka and Müller-Hermelink classification in patients with thymic tumors. 61
10881840 2000
16
Thymic carcinoma--analysis of nineteen clinicopathological studies. 61
11028718 2000
17
Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. 61
10705015 2000
18
Cytology of thymomas: emphasis on morphology and correlation with histologic subtypes. 61
10692213 2000
19
Evaluation of the malignant grade of thymic epithelial tumors according to the epithelial subclassification. 61
10648082 2000
20
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? 61
10047676 1999
21
Well-differentiated thymic carcinoma: is it thymic carcinoma or not? 61
10047677 1999
22
[Clinico-pathologic characteristics of malignant thymoma]. 61
11776857 1999
23
Thymic tumours in Denmark. A retrospective study of 213 cases from 1970-1993. 61
10483587 1999
24
Ki67 labelling index correlates with stage and histology but not significantly with prognosis in thymoma. 61
9839170 1998
25
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. 61
9619646 1998
26
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. 61
9463585 1998
27
Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. 61
9255257 1997
28
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. 61
8543314 1996
29
Recurrent thymoma: evidence for histological progression. 61
8575735 1995
30
Reproducibility of a histogenetic classification of thymic epithelial tumours. 61
7607622 1995
31
The clinicopathological correlation of epithelial subtyping in thymoma: a study of 112 consecutive cases. 61
8088764 1994
32
Thymoma. Histologic subclassification is an independent prognostic factor. 61
8033040 1994
33
Evaluation of a histogenetic classification for thymic epithelial tumours. 61
7959642 1994
34
Distribution of molecules mediating thymocyte-stroma-interactions in human thymus, thymitis and thymic epithelial tumors. 61
7725387 1994
35
Expression of epidermal and nerve growth factor receptors in human thymus and thymomas. 61
8365713 1993
36
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. 61
1463094 1992
37
Well-differentiated thymic carcinoma: a clinico-pathological study. 61
1549907 1992
38
Evaluation of prognostic features in thymic epithelial tumors. 61
2623740 1989
39
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy. 61
2450971 1988

Variations for Epithelial Malignant Thymoma

Expression for Epithelial Malignant Thymoma

Search GEO for disease gene expression data for Epithelial Malignant Thymoma.

Pathways for Epithelial Malignant Thymoma

GO Terms for Epithelial Malignant Thymoma

Sources for Epithelial Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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