MCID: EPT005
MIFTS: 23

Epithelial Predominant Wilms' Tumor

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Epithelial Predominant Wilms' Tumor

MalaCards integrated aliases for Epithelial Predominant Wilms' Tumor:

Name: Epithelial Predominant Wilms' Tumor 12 15 73
Epithelial Predominant Kidney Adenosarcoma 12
Epithelial Predominant Renal Wilms Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5189
NCIt 50 C9146
UMLS 73 C0279608

Summaries for Epithelial Predominant Wilms' Tumor

MalaCards based summary : Epithelial Predominant Wilms' Tumor, also known as epithelial predominant kidney adenosarcoma, is related to kidney rhabdoid cancer and bone ewing's sarcoma, and has symptoms including abdominal pain An important gene associated with Epithelial Predominant Wilms' Tumor is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone.

Related Diseases for Epithelial Predominant Wilms' Tumor

Diseases related to Epithelial Predominant Wilms' Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 kidney rhabdoid cancer 10.2 B3GAT1 WT1
2 bone ewing's sarcoma 10.2 B3GAT1 WT1
3 clear cell papillary renal cell carcinoma 10.2 AMACR KRT7
4 papillary adenoma 10.2 AMACR KRT7
5 nephrogenic adenoma 10.2 AMACR KRT7
6 benign mesothelioma 10.1 KRT7 WT1
7 endosalpingiosis 10.1 KRT7 WT1
8 collecting duct carcinoma 10.1 AMACR KRT7
9 female reproductive endometrioid cancer 10.1 KRT7 WT1
10 malignant biphasic mesothelioma 10.1 KRT7 WT1
11 mucinous adenocarcinoma 10.1 CDX2 KRT7
12 adenomatoid tumor 10.1 KRT7 WT1
13 ovary neuroendocrine neoplasm 10.1 CDX2 KRT7
14 natural killer cell leukemia 10.1 B3GAT1 NCAM1
15 appendix adenocarcinoma 10.1 CDX2 KRT7
16 mucinous adenofibroma 10.1 CDX2 KRT7
17 anus adenocarcinoma 10.1 CDX2 KRT7
18 glandular cystitis 10.1 CDX2 KRT7
19 peritoneum cancer 10.1 KRT7 WT1
20 gastric small cell carcinoma 10.1 B3GAT1 NCAM1
21 duodenum adenocarcinoma 10.1 CDX2 KRT7
22 chronic nk-cell lymphocytosis 10.1 B3GAT1 NCAM1
23 jejunal adenocarcinoma 10.1 CDX2 KRT7
24 nasal cavity cancer 10.1 CDX2 KRT7
25 thymus adenocarcinoma 10.1 CDX2 KRT7
26 appendix disease 10.1 CDX2 KRT7
27 gastric diffuse adenocarcinoma 10.1 CDX2 KRT7
28 sertoli-leydig cell tumor 10.1 KRT7 WT1
29 bladder adenocarcinoma 10.1 CDX2 KRT7
30 plasma cell leukemia 10.1 MAF NCAM1
31 nasal cavity adenocarcinoma 10.1 CDX2 KRT7
32 chronic cystitis 10.1 CDX2 KRT7
33 vulva adenocarcinoma 10.1 CDX2 KRT7
34 anal canal adenocarcinoma 10.1 CDX2 KRT7
35 rectum adenocarcinoma 10.1 CDX2 KRT7
36 mucinous ovarian cystadenoma 10.1 CDX2 KRT7
37 mucinous bronchioloalveolar adenocarcinoma 10.1 CDX2 KRT7
38 fallopian tube carcinosarcoma 10.1 NCAM1 WT1
39 ampulla of vater adenocarcinoma 10.1 CDX2 KRT7
40 biliary papillomatosis 10.1 CDX2 KRT7
41 duodenal disease 10.1 CDX2 KRT7
42 endocervical adenocarcinoma 10.1 CDX2 KRT7
43 cervical adenocarcinoma 10.1 CDX2 KRT7
44 appendix cancer 10.1 CDX2 KRT7
45 cystic teratoma 10.1 CDX2 KRT7
46 teratoma 10.1 CDX2 KRT7
47 horseshoe kidney 10.1 CDX2 KRT7
48 biliary tract neoplasm 10.1 CDX2 KRT7
49 duodenum cancer 10.1 CDX2 KRT7
50 pediatric lymphoma 10.1 B3GAT1 NCAM1

Graphical network of the top 20 diseases related to Epithelial Predominant Wilms' Tumor:



Diseases related to Epithelial Predominant Wilms' Tumor

Symptoms & Phenotypes for Epithelial Predominant Wilms' Tumor

UMLS symptoms related to Epithelial Predominant Wilms' Tumor:


abdominal pain

Drugs & Therapeutics for Epithelial Predominant Wilms' Tumor

Drugs for Epithelial Predominant Wilms' Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
3
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
7
Doxil Approved June 1999 Phase 3 31703
8 Immunologic Factors Phase 3
9 Antineoplastic Agents, Alkylating Phase 3
10 Anti-Infective Agents Phase 3
11 Etoposide phosphate Phase 3
12 Anti-Bacterial Agents Phase 3
13 Alkylating Agents Phase 3
14 Antimitotic Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Antineoplastic Agents, Phytogenic Phase 3
17 Topoisomerase Inhibitors Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Immunosuppressive Agents Phase 3
20 Nucleic Acid Synthesis Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor Unknown status NCT00047138 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors Completed NCT01004783

Search NIH Clinical Center for Epithelial Predominant Wilms' Tumor

Genetic Tests for Epithelial Predominant Wilms' Tumor

Anatomical Context for Epithelial Predominant Wilms' Tumor

MalaCards organs/tissues related to Epithelial Predominant Wilms' Tumor:

41
Kidney, Lung, Bone, Ovary, Thymus, Small Intestine, Appendix

Publications for Epithelial Predominant Wilms' Tumor

Variations for Epithelial Predominant Wilms' Tumor

Expression for Epithelial Predominant Wilms' Tumor

Search GEO for disease gene expression data for Epithelial Predominant Wilms' Tumor.

Pathways for Epithelial Predominant Wilms' Tumor

Pathways related to Epithelial Predominant Wilms' Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 MAF PRCC WT1
2 10.92 CDX2 NCAM1 WT1

GO Terms for Epithelial Predominant Wilms' Tumor

Sources for Epithelial Predominant Wilms' Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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