MCID: EPT005
MIFTS: 24

Epithelial Predominant Wilms' Tumor

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Epithelial Predominant Wilms' Tumor

MalaCards integrated aliases for Epithelial Predominant Wilms' Tumor:

Name: Epithelial Predominant Wilms' Tumor 12 15 74
Epithelial Predominant Kidney Adenosarcoma 12
Epithelial Predominant Renal Wilms Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5189
NCIt 51 C9146
UMLS 74 C0279608

Summaries for Epithelial Predominant Wilms' Tumor

MalaCards based summary : Epithelial Predominant Wilms' Tumor, also known as epithelial predominant kidney adenosarcoma, is related to kidney rhabdoid cancer and bone ewing's sarcoma, and has symptoms including abdominal pain An important gene associated with Epithelial Predominant Wilms' Tumor is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Epithelial Predominant Wilms' Tumor

Diseases related to Epithelial Predominant Wilms' Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 kidney rhabdoid cancer 10.3 B3GAT1 WT1
2 bone ewing's sarcoma 10.3 B3GAT1 WT1
3 benign mesothelioma 10.2 KRT7 WT1
4 endosalpingiosis 10.2 KRT7 WT1
5 female reproductive endometrioid cancer 10.2 KRT7 WT1
6 malignant biphasic mesothelioma 10.2 KRT7 WT1
7 adenomatoid tumor 10.2 KRT7 WT1
8 peritoneum cancer 10.2 KRT7 WT1
9 sertoli-leydig cell tumor 10.2 KRT7 WT1
10 clear cell papillary renal cell carcinoma 10.2 AMACR KRT7
11 papillary adenoma 10.2 AMACR KRT7
12 nephrogenic adenoma 10.2 AMACR KRT7
13 fallopian tube carcinosarcoma 10.2 NCAM1 WT1
14 mucinous adenocarcinoma 10.2 CDX2 KRT7
15 natural killer cell leukemia 10.2 B3GAT1 NCAM1
16 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
17 appendix adenocarcinoma 10.2 CDX2 KRT7
18 mucinous adenofibroma 10.2 CDX2 KRT7
19 anus adenocarcinoma 10.2 CDX2 KRT7
20 glandular cystitis 10.2 CDX2 KRT7
21 gastric small cell carcinoma 10.2 B3GAT1 NCAM1
22 duodenum adenocarcinoma 10.2 CDX2 KRT7
23 chronic nk-cell lymphocytosis 10.2 B3GAT1 NCAM1
24 jejunal adenocarcinoma 10.2 CDX2 KRT7
25 nasal cavity cancer 10.2 CDX2 KRT7
26 thymus adenocarcinoma 10.2 CDX2 KRT7
27 appendix disease 10.2 CDX2 KRT7
28 plasma cell leukemia 10.2 MAF NCAM1
29 gastric diffuse adenocarcinoma 10.2 CDX2 KRT7
30 bladder adenocarcinoma 10.2 CDX2 KRT7
31 nasal cavity adenocarcinoma 10.2 CDX2 KRT7
32 chronic cystitis 10.2 CDX2 KRT7
33 vulva adenocarcinoma 10.2 CDX2 KRT7
34 collecting duct carcinoma 10.2 AMACR KRT7
35 anal canal adenocarcinoma 10.2 CDX2 KRT7
36 rectum adenocarcinoma 10.2 CDX2 KRT7
37 mucinous ovarian cystadenoma 10.1 CDX2 KRT7
38 mucinous bronchioloalveolar adenocarcinoma 10.1 CDX2 KRT7
39 ampulla of vater adenocarcinoma 10.1 CDX2 KRT7
40 biliary papillomatosis 10.1 CDX2 KRT7
41 endocervical adenocarcinoma 10.1 CDX2 KRT7
42 cervical adenocarcinoma 10.1 CDX2 KRT7
43 ovarian brenner tumor 10.1 KRT7 WT1
44 appendix cancer 10.1 CDX2 KRT7
45 cystic teratoma 10.1 CDX2 KRT7
46 teratoma 10.1 CDX2 KRT7
47 sex cord-gonadal stromal tumor 10.1 KRT7 WT1
48 horseshoe kidney 10.1 CDX2 KRT7
49 duodenum cancer 10.1 CDX2 KRT7
50 pediatric lymphoma 10.1 B3GAT1 NCAM1

Graphical network of the top 20 diseases related to Epithelial Predominant Wilms' Tumor:



Diseases related to Epithelial Predominant Wilms' Tumor

Symptoms & Phenotypes for Epithelial Predominant Wilms' Tumor

UMLS symptoms related to Epithelial Predominant Wilms' Tumor:


abdominal pain

Drugs & Therapeutics for Epithelial Predominant Wilms' Tumor

Drugs for Epithelial Predominant Wilms' Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
2
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
3
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
7
Doxil Approved June 1999 Phase 3 31703
8 Anti-Bacterial Agents Phase 3
9 Antineoplastic Agents, Alkylating Phase 3
10 Etoposide phosphate Phase 3
11 Anti-Infective Agents Phase 3
12 Immunosuppressive Agents Phase 3
13 Immunologic Factors Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 3
15 Topoisomerase Inhibitors Phase 3
16 Alkylating Agents Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Antimitotic Agents Phase 3
19 Antineoplastic Agents, Phytogenic Phase 3
20 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor Unknown status NCT00047138 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors Completed NCT01004783

Search NIH Clinical Center for Epithelial Predominant Wilms' Tumor

Genetic Tests for Epithelial Predominant Wilms' Tumor

Anatomical Context for Epithelial Predominant Wilms' Tumor

MalaCards organs/tissues related to Epithelial Predominant Wilms' Tumor:

42
Kidney

Publications for Epithelial Predominant Wilms' Tumor

Variations for Epithelial Predominant Wilms' Tumor

Expression for Epithelial Predominant Wilms' Tumor

Search GEO for disease gene expression data for Epithelial Predominant Wilms' Tumor.

Pathways for Epithelial Predominant Wilms' Tumor

Pathways related to Epithelial Predominant Wilms' Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 MAF PRCC WT1
2 10.92 CDX2 NCAM1 WT1

GO Terms for Epithelial Predominant Wilms' Tumor

Sources for Epithelial Predominant Wilms' Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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