MCID: EPT005
MIFTS: 24

Epithelial Predominant Wilms' Tumor

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Epithelial Predominant Wilms' Tumor

MalaCards integrated aliases for Epithelial Predominant Wilms' Tumor:

Name: Epithelial Predominant Wilms' Tumor 12 15 73
Epithelial Predominant Kidney Adenosarcoma 12
Epithelial Predominant Renal Wilms Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5189
NCIt 50 C9146
UMLS 73 C0279608

Summaries for Epithelial Predominant Wilms' Tumor

MalaCards based summary : Epithelial Predominant Wilms' Tumor, also known as epithelial predominant kidney adenosarcoma, is related to kidney rhabdoid cancer and bone ewing's sarcoma, and has symptoms including abdominal pain An important gene associated with Epithelial Predominant Wilms' Tumor is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Etoposide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Epithelial Predominant Wilms' Tumor

Diseases related to Epithelial Predominant Wilms' Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 kidney rhabdoid cancer 10.7 B3GAT1 WT1
2 bone ewing's sarcoma 10.6 B3GAT1 WT1
3 clear cell papillary renal cell carcinoma 10.5 AMACR KRT7
4 nephrogenic adenoma 10.5 AMACR KRT7
5 endosalpingiosis 10.5 KRT7 WT1
6 female reproductive endometrioid cancer 10.5 KRT7 WT1
7 kidney benign neoplasm 10.4 AMACR KRT7
8 adenomatoid tumor 10.4 KRT7 WT1
9 collecting duct carcinoma 10.4 AMACR KRT7
10 sertoli-leydig cell tumor 10.4 KRT7 WT1
11 malignant biphasic mesothelioma 10.4 KRT7 WT1
12 ovary neuroendocrine neoplasm 10.4 CDX2 KRT7
13 vaginal benign neoplasm 10.4 CDX2 KRT7
14 appendix adenocarcinoma 10.4 CDX2 KRT7
15 vaginal adenoma 10.4 CDX2 KRT7
16 vaginal tubulovillous adenoma 10.4 CDX2 KRT7
17 mucinous adenofibroma 10.4 CDX2 KRT7
18 anus adenocarcinoma 10.4 CDX2 KRT7
19 glandular cystitis 10.4 CDX2 KRT7
20 gastric small cell carcinoma 10.4 B3GAT1 NCAM1
21 fallopian tube carcinosarcoma 10.4 NCAM1 WT1
22 mucinous bronchioloalveolar adenocarcinoma 10.4 CDX2 KRT7
23 thymus adenocarcinoma 10.4 CDX2 KRT7
24 bronchiolo-alveolar adenocarcinoma 10.4 CDX2 KRT7
25 gastric diffuse adenocarcinoma 10.4 CDX2 KRT7
26 bladder adenocarcinoma 10.3 CDX2 KRT7
27 nasal cavity adenocarcinoma 10.3 CDX2 KRT7
28 jejunal adenocarcinoma 10.3 CDX2 KRT7
29 chronic cystitis 10.3 CDX2 KRT7
30 chronic nk-cell lymphocytosis 10.3 B3GAT1 NCAM1
31 vulva adenocarcinoma 10.3 CDX2 KRT7
32 mucinous ovarian cystadenoma 10.3 CDX2 KRT7
33 anal canal adenocarcinoma 10.3 CDX2 KRT7
34 rectum adenocarcinoma 10.3 CDX2 KRT7
35 benign mesothelioma 10.3 KRT7 WT1
36 ampulla of vater neoplasm 10.3 CDX2 KRT7
37 appendix cancer 10.3 CDX2 KRT7
38 ampulla of vater adenocarcinoma 10.3 CDX2 KRT7
39 biliary papillomatosis 10.3 CDX2 KRT7
40 endocervical adenocarcinoma 10.3 CDX2 KRT7
41 plasma cell leukemia 10.3 MAF NCAM1
42 cystic teratoma 10.3 CDX2 KRT7
43 horseshoe kidney 10.3 CDX2 KRT7
44 biliary tract neoplasm 10.3 CDX2 KRT7
45 duodenum cancer 10.3 CDX2 KRT7
46 spindle cell carcinoma 10.3 AMACR KRT7
47 ovarian brenner tumor 10.3 KRT7 WT1
48 adenocarcinoma in situ 10.3 CDX2 KRT7
49 hidradenocarcinoma 10.3 CDX2 KRT7
50 pediatric lymphoma 10.3 B3GAT1 NCAM1

Graphical network of the top 20 diseases related to Epithelial Predominant Wilms' Tumor:



Diseases related to Epithelial Predominant Wilms' Tumor

Symptoms & Phenotypes for Epithelial Predominant Wilms' Tumor

UMLS symptoms related to Epithelial Predominant Wilms' Tumor:


abdominal pain

Drugs & Therapeutics for Epithelial Predominant Wilms' Tumor

Drugs for Epithelial Predominant Wilms' Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
4
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
7
Doxil Approved June 1999 Phase 3 31703
8 Alkylating Agents Phase 3
9 Topoisomerase Inhibitors Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3
11 Anti-Bacterial Agents Phase 3
12 Antibiotics, Antitubercular Phase 3
13 Etoposide phosphate Phase 3
14 Immunosuppressive Agents Phase 3
15 Anti-Infective Agents Phase 3
16 Antirheumatic Agents Phase 3
17 Antimitotic Agents Phase 3
18 Antineoplastic Agents, Alkylating Phase 3
19 Antineoplastic Agents, Phytogenic Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor Unknown status NCT00047138 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors Completed NCT01004783

Search NIH Clinical Center for Epithelial Predominant Wilms' Tumor

Genetic Tests for Epithelial Predominant Wilms' Tumor

Anatomical Context for Epithelial Predominant Wilms' Tumor

MalaCards organs/tissues related to Epithelial Predominant Wilms' Tumor:

41
Kidney

Publications for Epithelial Predominant Wilms' Tumor

Variations for Epithelial Predominant Wilms' Tumor

Expression for Epithelial Predominant Wilms' Tumor

Search GEO for disease gene expression data for Epithelial Predominant Wilms' Tumor.

Pathways for Epithelial Predominant Wilms' Tumor

Pathways related to Epithelial Predominant Wilms' Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 MAF PRCC WT1
2 10.92 CDX2 NCAM1 WT1

GO Terms for Epithelial Predominant Wilms' Tumor

Sources for Epithelial Predominant Wilms' Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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