MCID: EPT001
MIFTS: 21

Epithelioid Cell Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Epithelioid Cell Melanoma

MalaCards integrated aliases for Epithelioid Cell Melanoma:

Name: Epithelioid Cell Melanoma 12 15 71
Epithelioid Melanoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4360
NCIt 50 C4236
SNOMED-CT 67 37138001
UMLS 71 C0334443

Summaries for Epithelioid Cell Melanoma

MalaCards based summary : Epithelioid Cell Melanoma, also known as epithelioid melanoma, is related to melanoma and skin melanoma. An important gene associated with Epithelioid Cell Melanoma is MIR9-1 (MicroRNA 9-1). Related phenotype is pigmentation.

Related Diseases for Epithelioid Cell Melanoma

Diseases related to Epithelioid Cell Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 melanoma 28.7 TYR NGFR MLANA MITF MIR374A GNA11
2 skin melanoma 28.6 TYR NGFR MLANA MITF GNA11
3 choroid epithelioid cell melanoma 11.5
4 uveal epithelioid cell melanoma 11.4
5 ciliary body epithelioid cell melanoma 11.4
6 lentigo maligna melanoma 10.2 MLANA MITF
7 pigmented basal cell carcinoma 10.2 MLANA MITF
8 gallbladder melanoma 10.2 MLANA MITF
9 uterus perivascular epithelioid cell tumor 10.2 MLANA MITF
10 perivascular epithelioid cell tumor 10.2 MLANA MITF
11 malignant choroid melanoma 10.2 MLANA MITF
12 melanomatosis 10.2 TYR MLANA
13 ciliary body cancer 10.2 TYR MLANA
14 melanoacanthoma 10.2 TYR MLANA
15 halo nevi 10.2 TYR MLANA
16 sarcomatoid transitional cell carcinoma 10.2 TYR MLANA
17 spinal cord melanoma 10.2 TYR MLANA
18 diffuse meningeal melanocytosis 10.2 TYR MLANA
19 melanoma, cutaneous malignant 8 10.2 TYR MITF
20 ochronosis 10.2 TYR MITF
21 ocular albinism with congenital sensorineural deafness 10.2 TYR MITF
22 orbit rhabdomyosarcoma 10.2 TYR MLANA
23 orofacial cleft 8 10.1 TYR MLANA
24 albinism, ocular, with late-onset sensorineural deafness 10.1 TYR MITF
25 choroid cancer 10.1 MRPS21 MLANA
26 dowling-degos disease 1 10.1 TYR MITF
27 waardenburg syndrome, type 4b 10.1 TYR MITF
28 waardenburg syndrome, type 3 10.1 TYR MITF
29 tietz albinism-deafness syndrome 10.1 TYR MITF
30 waardenburg syndrome, type 2e 10.1 TYR MITF
31 waardenburg syndrome, type 2a 10.1 TYR MITF
32 amelanotic melanoma 10.1 TYR MLANA
33 waardenburg syndrome, type 1 10.1 TYR MITF
34 keratosis, seborrheic 10.1 TYR MLANA
35 pigmentation disease 10.1 TYR MITF
36 waardenburg syndrome, type 4a 10.0 TYR MITF
37 vascular cancer 10.0 MLANA MITF
38 angiomyolipoma 10.0 TYR MLANA MITF
39 clear cell sarcoma 10.0 TYR MLANA MITF
40 neurofibroma 10.0 TYR MLANA MITF
41 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0 TYR MLANA MITF
42 ocular albinism 10.0 TYR MLANA MITF
43 autoimmune disease of skin and connective tissue 10.0 TYR MITF
44 meningeal melanomatosis 10.0 MLANA GNA11
45 meningeal melanocytoma 10.0 MLANA GNA11
46 malignant anus melanoma 10.0 MLANA GNA11
47 malignant dermis tumor 10.0 MLANA GNA11
48 macular holes 10.0 MIR93 MIR9-1 MIR374A
49 central nervous system melanocytic neoplasm 10.0 MLANA GNA11
50 malignant skin fibrous histiocytoma 10.0 MLANA GNA11

Graphical network of the top 20 diseases related to Epithelioid Cell Melanoma:



Diseases related to Epithelioid Cell Melanoma

Symptoms & Phenotypes for Epithelioid Cell Melanoma

MGI Mouse Phenotypes related to Epithelioid Cell Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 GNA11 MITF MLANA TYR

Drugs & Therapeutics for Epithelioid Cell Melanoma

Search Clinical Trials , NIH Clinical Center for Epithelioid Cell Melanoma

Genetic Tests for Epithelioid Cell Melanoma

Anatomical Context for Epithelioid Cell Melanoma

Publications for Epithelioid Cell Melanoma

Articles related to Epithelioid Cell Melanoma:

(show all 33)
# Title Authors PMID Year
1
Malignant melanoma in situ associated with underlying sarcoidal granuloma: A histopathological mimicker of invasive epithelioid melanoma cells. 61
32940353 2021
2
PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa). 61
31851063 2020
3
Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations. 61
31025390 2019
4
Heavily Pigmented Epithelioid Melanoma With Loss of Protein Kinase A Regulatory Subunit-α Expression. 61
29771690 2018
5
Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. 61
30278339 2018
6
PNL2: an adjunctive biomarker for renal angiomyolipomas and perivascular epithelioid cell tumours. 61
28837273 2018
7
A large metastatic intramammary lesion of an occult melanoma. 61
28944768 2017
8
Orbital Extension of an Unsuspected Choroidal Melanoma Presumably through an Aqueous Tube Shunt. 61
27239454 2016
9
Aggressive skull base metastasis from uveal melanoma: a clinicopathologic study. 61
24729140 2014
10
Epithelioid angiomyolipoma: a morphologically distinct variant that mimics a variety of intra-abdominal neoplasms. 61
21526965 2011
11
Epithelioid melanoma of the rectum: reappraisal of a deceptive microscopic simulator. 61
20952303 2011
12
Genotypic profiling of 452 choroidal melanomas with multiplex ligation-dependent probe amplification. 61
20975103 2010
13
Cytological features of melanoma in exfoliative fluid specimens. 61
19561232 2009
14
Amelanotic metastasis of melanoma mimicking ovarian cancer: a case report and review of the literature. 61
18383903 2008
15
WT1 as a complementary marker of malignant melanoma: an immunohistochemical study of whole sections. 61
17927581 2007
16
Two discrete uveal melanomas in a child with ocular melanocytosis. 61
16829813 2006
17
Conjunctival metastasis as initial sign of disseminated cutaneous melanoma. 61
15465560 2004
18
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. 61
12472287 2002
19
Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters. 61
12419830 2002
20
Malignant melanoma of the eyelid in a red squirrel (Sciurus vulgaris orientis). 61
11999447 2002
21
Role for microphthalmia transcription factor in the diagnosis of metastatic malignant melanoma. 61
11893035 2002
22
Microphthalmia transcription factor: not a sensitive or specific marker for the diagnosis of desmoplastic melanoma and spindle cell (non-desmoplastic) melanoma. 61
11391097 2001
23
Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation. 61
11211309 2001
24
Microphthalmia transcription factor and melanoma cell adhesion molecule expression distinguish desmoplastic/spindle cell melanoma from morphologic mimics. 61
11145252 2001
25
Iris mammillations as the only sign of ocular melanocytosis in a child with choroidal melanoma. 61
10815167 2000
26
Periorbital melanocytic lesions: excision and reconstruction in 40 patients. 61
9655402 1998
27
Role of cytopathology in the diagnosis of ocular malignancies. 61
9568136 1998
28
Conjunctival metastasis from a cutaneous melanoma as the initial sign of dissemination. 61
9186141 1997
29
Nevoid melanoma: a clinicopathological study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus and verrucous dermal nevus. 61
7860047 1995
30
Iris melanoma seeding through a trabeculectomy site. 61
2400348 1990
31
Neovascular glaucoma associated with an iris melanoma. A clinicopathologic report. 61
3619744 1987
32
Proton-beam irradiated epithelioid cell melanoma of the ciliary body. 61
6275325 1981
33
Survival rate of patients with choroidal melanoma. 61
1004815 1976

Variations for Epithelioid Cell Melanoma

Expression for Epithelioid Cell Melanoma

Search GEO for disease gene expression data for Epithelioid Cell Melanoma.

Pathways for Epithelioid Cell Melanoma

GO Terms for Epithelioid Cell Melanoma

Biological processes related to Epithelioid Cell Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.26 MIR93 MIR9-1 MIR639 MIR374A
2 pigmentation GO:0043473 9.16 TYR MITF
3 negative regulation of cell migration GO:0030336 8.8 MITF MIR93 MIR9-1

Molecular functions related to Epithelioid Cell Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.13 MIR93 MIR9-1 MIR374A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.92 MIR93 MIR9-1 MIR639 MIR374A

Sources for Epithelioid Cell Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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