MCID: EPT009
MIFTS: 26

Epithelioid Cell Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Epithelioid Cell Synovial Sarcoma

MalaCards integrated aliases for Epithelioid Cell Synovial Sarcoma:

Name: Epithelioid Cell Synovial Sarcoma 12 15
Synovial Sarcoma, Epithelioid Cell 12 70
Epithelioid Synovial Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5494
NCIt 50 C4278
SNOMED-CT 67 56422000
UMLS 70 C0334506

Summaries for Epithelioid Cell Synovial Sarcoma

MalaCards based summary : Epithelioid Cell Synovial Sarcoma, also known as synovial sarcoma, epithelioid cell, is related to sarcoma and spindle cell sarcoma. An important gene associated with Epithelioid Cell Synovial Sarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcriptional misregulation in cancer. Affiliated tissues include breast, kidney and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Epithelioid Cell Synovial Sarcoma

Diseases related to Epithelioid Cell Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.1 WT1 SSX2 SSX1 SS18 EWSR1
2 spindle cell sarcoma 29.7 SSX2 SSX1 SS18 KRT7 EWSR1 CD34
3 sarcoma, synovial 28.3 WT1 SSX2 SSX1 SS18 KRT7 EWSR1
4 meninges sarcoma 10.4 SSX2 SS18
5 malignant glandular tumor of peripheral nerve sheath 10.4 SSX2 CALB2
6 extraskeletal mesenchymal chondrosarcoma 10.3 EWSR1 CD99
7 pulmonary vein leiomyosarcoma 10.3 CD99 CD34
8 ewing sarcoma of bone 10.3 EWSR1 CD99
9 rete testis adenoma 10.3 PAX8 CALB2
10 small intestine leiomyosarcoma 10.3 CD34 ANO1
11 parasagittal meningioma 10.3 CD34 ANO1
12 central nervous system mesenchymal non-meningothelial tumor 10.3 EWSR1 CD99
13 gastric liposarcoma 10.3 CD34 ANO1
14 adult fibrosarcoma 10.3 SSX1 CD34
15 deep leiomyoma 10.3 CD34 ANO1
16 meninges hemangiopericytoma 10.3 CD99 CD34
17 epidural spinal canal neoplasm 10.3 CD99 CD34
18 infected hydrocele 10.3 SPN CALB2
19 liver leiomyoma 10.3 CD34 ANO1
20 extraosseous osteosarcoma 10.3 SSX1 CD34
21 small intestine leiomyoma 10.3 CD34 ANO1
22 sclerosing liposarcoma 10.3 PAX8 CD34
23 retroperitoneal leiomyosarcoma 10.3 CD34 ANO1
24 spermatocytoma 10.3 SSX2 CTAG1B CTAG1A
25 thyroid sarcoma 10.3 PAX8 CD34
26 mixed endometrial stromal and smooth muscle tumor 10.3 MME CD99
27 malignant mesenchymoma 10.3 SSX2 CD34
28 intravascular fasciitis 10.3 CD34 ANO1
29 benign fibrous mesothelioma 10.2 CD34 CALB2
30 peritoneal benign neoplasm 10.2 CD34 CALB2
31 heart sarcoma 10.2 SSX2 SSX1 CD34
32 pleomorphic liposarcoma 10.2 SSX2 SS18 EWSR1
33 spindle cell lipoma 10.2 CD99 CD34
34 esophagus sarcoma 10.2 SSX2 CD34
35 cellular schwannoma 10.2 SSX1 SS18 CD34
36 vulvar sarcoma 10.2 EWSR1 CD34
37 thyroid angiosarcoma 10.2 PAX8 CD34
38 epithelioid malignant peripheral nerve sheath tumor 10.2 SSX2 SS18 CD34
39 bladder lymphoma 10.2 SPN MME
40 transitional papilloma 10.2 UPK3A KRT7
41 renal pelvis transitional cell carcinoma 10.2 UPK3A KRT7
42 retroperitoneal sarcoma 10.2 SSX2 CD34 ANO1
43 lung lymphoma 10.2 SPN MME
44 vulva adenocarcinoma 10.2 UPK3A KRT7
45 vulval paget's disease 10.2 UPK3A KRT7
46 bone lymphoma 10.2 SPN MME
47 cervical carcinosarcoma 10.2 MME CALB2
48 fallopian tube carcinosarcoma 10.2 WT1 CALB2
49 breast lymphoma 10.2 SPN MME
50 gastric squamous cell carcinoma 10.2 UPK3A KRT7

Graphical network of the top 20 diseases related to Epithelioid Cell Synovial Sarcoma:



Diseases related to Epithelioid Cell Synovial Sarcoma

Symptoms & Phenotypes for Epithelioid Cell Synovial Sarcoma

GenomeRNAi Phenotypes related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.74 EWSR1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.74 EWSR1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.74 EWSR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.74 PAX8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.74 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.74 PAX8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.74 PAX8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.74 PAX8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.74 EWSR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.74 SSX1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.74 PAX8
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-3 9.74 PAX8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.74 PAX8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-41 9.74 PAX8
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.74 PAX8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.74 EWSR1 SSX1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.74 EWSR1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.74 SSX2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.74 EWSR1 PAX8
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.74 EWSR1 PAX8 SSX2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.74 EWSR1
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 9.74 PAX8

Drugs & Therapeutics for Epithelioid Cell Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Epithelioid Cell Synovial Sarcoma

Genetic Tests for Epithelioid Cell Synovial Sarcoma

Anatomical Context for Epithelioid Cell Synovial Sarcoma

MalaCards organs/tissues related to Epithelioid Cell Synovial Sarcoma:

40
Breast, Kidney, Lung, Ovary, Bone, Small Intestine, Liver

Publications for Epithelioid Cell Synovial Sarcoma

Articles related to Epithelioid Cell Synovial Sarcoma:

# Title Authors PMID Year
1
Pathology quiz case 1. Epithelioid synovial sarcoma (synoviosarcoma). 61
17116828 2006
2
Detection of a variant SYT-SSX1 fusion in a case of predominantly epithelioid synovial sarcoma. 61
10229776 1999

Variations for Epithelioid Cell Synovial Sarcoma

Expression for Epithelioid Cell Synovial Sarcoma

Search GEO for disease gene expression data for Epithelioid Cell Synovial Sarcoma.

Pathways for Epithelioid Cell Synovial Sarcoma

Pathways related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 SPN MME CD34
2 11.38 WT1 SSX2 SSX1 SS18 PAX8 EWSR1
3 11 SPN MME CD34

GO Terms for Epithelioid Cell Synovial Sarcoma

Biological processes related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell morphogenesis GO:0000902 9.63 UPK3A SS18 GATA3
2 mesonephros development GO:0001823 9.48 PAX8 GATA3
3 mesenchymal to epithelial transition GO:0060231 9.43 WT1 GATA3
4 cellular response to gonadotropin stimulus GO:0071371 9.4 WT1 PAX8
5 otic vesicle development GO:0071599 9.37 PAX8 GATA3
6 metanephric S-shaped body morphogenesis GO:0072284 9.32 WT1 PAX8
7 metanephric epithelium development GO:0072207 9.26 WT1 PAX8
8 tRNA threonylcarbamoyladenosine metabolic process GO:0070525 9.16 CTAG1B CTAG1A
9 kidney development GO:0001822 9.02 WT1 UPK3A PAX8 MME GATA3
10 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3

Sources for Epithelioid Cell Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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