MCID: EPT009
MIFTS: 27

Epithelioid Cell Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Epithelioid Cell Synovial Sarcoma

MalaCards integrated aliases for Epithelioid Cell Synovial Sarcoma:

Name: Epithelioid Cell Synovial Sarcoma 12 15
Synovial Sarcoma, Epithelioid Cell 12 71
Epithelioid Synovial Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5494
NCIt 49 C4278
SNOMED-CT 67 56422000
UMLS 71 C0334506

Summaries for Epithelioid Cell Synovial Sarcoma

MalaCards based summary : Epithelioid Cell Synovial Sarcoma, also known as synovial sarcoma, epithelioid cell, is related to sarcoma and spindle cell sarcoma. An important gene associated with Epithelioid Cell Synovial Sarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include ovary, liver and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Epithelioid Cell Synovial Sarcoma

Diseases related to Epithelioid Cell Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.0 WT1 SSX2 SSX1 SS18 EWSR1
2 spindle cell sarcoma 29.8 SSX2 SSX1 SS18 KRT7 CD34
3 sarcoma, synovial 27.5 WT1 SSX2 SSX1 SS18 KRT7 EWSR1
4 bone angioendothelial sarcoma 10.6 SSX1 SS18
5 meninges sarcoma 10.5 SSX2 SS18
6 malignant glandular tumor of peripheral nerve sheath 10.5 SSX2 CALB2
7 urethra cancer 10.5 UPK3A PAX8
8 liver fibroma 10.5 SSX2 CALB2
9 malignant leydig cell tumor 10.4 SPN CALB2
10 extraskeletal mesenchymal chondrosarcoma 10.4 EWSR1 CD99
11 ewing sarcoma of bone 10.4 EWSR1 CD99
12 esophagus sarcoma 10.4 SSX2 CD34
13 pulmonary vein leiomyosarcoma 10.4 CD99 CD34
14 small intestinal sarcoma 10.4 CD34 ANO1
15 small intestine leiomyosarcoma 10.4 CD34 ANO1
16 colon leiomyosarcoma 10.4 CD34 ANO1
17 rete testis adenoma 10.4 PAX8 CALB2
18 parasagittal meningioma 10.4 CD34 ANO1
19 central nervous system mesenchymal non-meningothelial tumor 10.4 EWSR1 CD99
20 deep leiomyoma 10.4 CD34 ANO1
21 cerebral convexity meningioma 10.4 CD34 ANO1
22 meninges hemangiopericytoma 10.4 CD99 CD34
23 infected hydrocele 10.4 SPN CALB2
24 epidural neoplasm 10.4 CD99 CD34
25 small intestine leiomyoma 10.4 CD34 ANO1
26 extraosseous osteosarcoma 10.4 SSX1 CD34
27 intravascular fasciitis 10.4 CD34 ANO1
28 mesenchymoma 10.3 SSX2 CD34
29 retroperitoneal leiomyosarcoma 10.3 CD34 ANO1
30 myocardium cancer 10.3 SYP CD99
31 lung leiomyosarcoma 10.3 CD34 CALB2
32 heart sarcoma 10.3 SSX2 SSX1 CD34
33 pacinian tumor 10.3 CD34 CALB2
34 malignant mesenchymoma 10.3 SSX2 CD34
35 intracranial primitive neuroectodermal tumor 10.3 SYP CD99
36 spindle cell thymoma 10.3 CD34 CALB2
37 benign fibrous mesothelioma 10.3 CD34 CALB2
38 ovarian cystic teratoma 10.3 SYP CD99
39 nasal cavity neoplasm 10.3 EWSR1 CD34
40 cerebellopontine angle primitive neuroectodermal 10.3 SYP CD99
41 epithelioid malignant peripheral nerve sheath tumor 10.3 SSX2 SS18 CD34
42 spindle cell lipoma 10.3 CD99 CD34
43 esophageal adenoid cystic carcinoma 10.3 SYP ANO1
44 transitional papilloma 10.3 UPK3A KRT7
45 renal pelvis transitional cell carcinoma 10.3 UPK3A KRT7
46 vulval paget's disease 10.2 UPK3A KRT7
47 vulva adenocarcinoma 10.2 UPK3A KRT7
48 congenital mesoblastic nephroma 10.2 WT1 SSX2 SSX1
49 peritoneal serous adenocarcinoma 10.2 WT1 CALB2
50 malignant epithelial mesothelioma 10.2 WT1 CALB2

Graphical network of the top 20 diseases related to Epithelioid Cell Synovial Sarcoma:



Diseases related to Epithelioid Cell Synovial Sarcoma

Symptoms & Phenotypes for Epithelioid Cell Synovial Sarcoma

GenomeRNAi Phenotypes related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.87 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.87 EWSR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.87 SSX1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.87 EWSR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.87 EWSR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.87 EWSR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.87 PAX8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.87 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.87 SSX1 SSX2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.87 EWSR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.87 EWSR1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.87 PAX8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.87 EWSR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.87 SSX2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.87 SSX1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.87 PAX8
17 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.87 PAX8
18 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.87 SSX2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.87 PAX8
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.87 EWSR1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.87 PAX8
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.87 EWSR1 SSX1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.87 SSX1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.87 SSX2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.87 EWSR1 PAX8 SSX1 SSX2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.87 EWSR1 PAX8 SSX2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.87 PAX8
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.87 EWSR1

MGI Mouse Phenotypes related to Epithelioid Cell Synovial Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 ANO1 CD1D GATA3 KRT7 PAX8 UPK3A

Drugs & Therapeutics for Epithelioid Cell Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Epithelioid Cell Synovial Sarcoma

Genetic Tests for Epithelioid Cell Synovial Sarcoma

Anatomical Context for Epithelioid Cell Synovial Sarcoma

MalaCards organs/tissues related to Epithelioid Cell Synovial Sarcoma:

40
Ovary, Liver, Lung, Small Intestine, Kidney, Breast, Testis

Publications for Epithelioid Cell Synovial Sarcoma

Articles related to Epithelioid Cell Synovial Sarcoma:

# Title Authors PMID Year
1
Pathology quiz case 1. Epithelioid synovial sarcoma (synoviosarcoma). 61
17116828 2006
2
Detection of a variant SYT-SSX1 fusion in a case of predominantly epithelioid synovial sarcoma. 61
10229776 1999

Variations for Epithelioid Cell Synovial Sarcoma

Expression for Epithelioid Cell Synovial Sarcoma

Search GEO for disease gene expression data for Epithelioid Cell Synovial Sarcoma.

Pathways for Epithelioid Cell Synovial Sarcoma

Pathways related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.37 WT1 SSX2 SSX1 SS18 PAX8 EWSR1
2 11.2 SPN CD34 CD1D
3 10.86 SPN CD34 CD1D

GO Terms for Epithelioid Cell Synovial Sarcoma

Biological processes related to Epithelioid Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell morphogenesis GO:0000902 9.65 UPK3A SS18 GATA3
2 mesonephros development GO:0001823 9.46 PAX8 GATA3
3 mesenchymal to epithelial transition GO:0060231 9.43 WT1 GATA3
4 cellular response to gonadotropin stimulus GO:0071371 9.4 WT1 PAX8
5 otic vesicle development GO:0071599 9.37 PAX8 GATA3
6 metanephric S-shaped body morphogenesis GO:0072284 9.32 WT1 PAX8
7 metanephric epithelium development GO:0072207 9.26 WT1 PAX8
8 tRNA threonylcarbamoyladenosine metabolic process GO:0070525 9.16 CTAG1B CTAG1A
9 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3
10 kidney development GO:0001822 8.92 WT1 UPK3A PAX8 GATA3

Sources for Epithelioid Cell Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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