MCID: EPT011
MIFTS: 31

Epithelioid Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Epithelioid Leiomyosarcoma

MalaCards integrated aliases for Epithelioid Leiomyosarcoma:

Name: Epithelioid Leiomyosarcoma 12 15
Leiomyosarcoma, Epithelioid 74
Leiomyosarcoma Epithelioid 56

Classifications:



External Ids:

Disease Ontology 12 DOID:5264
MeSH 45 D007890
NCIt 51 C3700
SNOMED-CT 69 42392001
UMLS 74 C0205815

Summaries for Epithelioid Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is composed predominantly or entirely of round or polygonal cells with eosinophilic, or much less commonly, clear cytoplasm.

MalaCards based summary : Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and cutaneous leiomyosarcoma. An important gene associated with Epithelioid Leiomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include liver, uterus and cervix.

Related Diseases for Epithelioid Leiomyosarcoma

Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.5 ACTC1 DES ENO2 VIM
2 cutaneous leiomyosarcoma 30.2 ACTC1 DES
3 leiomyoma 29.6 ACTC1 DES VIM
4 spindle cell sarcoma 29.6 ACTC1 DES VIM
5 uterine corpus epithelioid leiomyosarcoma 12.3
6 conventional leiomyosarcoma 11.3
7 chordoma 10.3 DES VIM
8 infantile digital fibromatosis 10.2 DES VIM
9 lymphangiomatosis 10.2 DES VIM
10 biphasic synovial sarcoma 10.2 DES VIM
11 syringoma 10.2 DES VIM
12 cystic nephroma 10.2 DES VIM
13 juvenile xanthogranuloma 10.2 DES VIM
14 pleomorphic liposarcoma 10.2 DES VIM
15 liposarcoma 10.2 DES VIM
16 malignant ectomesenchymoma 10.2 DES ENO2
17 ectomesenchymoma 10.2 DES ENO2
18 mesenchymal chondrosarcoma 10.2 DES VIM
19 bednar tumor 10.2 ENO2 VIM
20 papillary tumor of the pineal region 10.2 ENO2 VIM
21 clear cell ependymoma 10.2 ENO2 VIM
22 ependymoma 10.2 ENO2 VIM
23 astroblastoma 10.1 ENO2 VIM
24 melanotic neuroectodermal tumor 10.1 ENO2 VIM
25 odontogenic myxoma 10.1 SERPINA3 VIM
26 chondroid chordoma 10.1 ENO2 VIM
27 multicentric reticulohistiocytosis 10.1 PTPRC VIM
28 medullomyoblastoma 10.1 DES ENO2
29 histiocytoma 10.1 PTPRC SERPINA3
30 retroperitoneal fibrosis 10.1 PTPRC VIM
31 cerebral primitive neuroectodermal tumor 10.1 ENO2 VIM
32 paraganglioma 10.1
33 chondroma 10.1
34 nonsyndromic paraganglioma 10.1
35 cavernous hemangioma 10.1 DES VIM
36 liver angiosarcoma 10.1 ENO2 VIM
37 plasmablastic lymphoma 10.1 DES PTPRC
38 gastric squamous cell carcinoma 10.1 ENO2 SERPINA3
39 muscle cancer 10.1 DES ENO2
40 nodular tenosynovitis 10.1 PTPRC SERPINA3
41 pericardial mesothelioma 10.1 ENO2 VIM
42 histiocytosis 10.1 PTPRC SERPINA3
43 optic nerve glioma 10.1 ENO2 VIM
44 conventional fibrosarcoma 10.1 ENO2 PTPRC
45 kidney rhabdoid cancer 10.1 ENO2 PTPRC
46 endometrial small cell carcinoma 10.1 ENO2 PTPRC
47 mucinous cystadenocarcinoma 10.1 PTPRC VIM
48 small cell carcinoma 10.1 ENO2 PTPRC
49 retinal hemangioblastoma 10.0 ENO2 SERPINA3
50 gastric small cell carcinoma 10.0 ENO2 PTPRC

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to Epithelioid Leiomyosarcoma

Symptoms & Phenotypes for Epithelioid Leiomyosarcoma

Drugs & Therapeutics for Epithelioid Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

Anatomical Context for Epithelioid Leiomyosarcoma

MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

42
Liver, Uterus, Cervix, Bone, Smooth Muscle, Kidney, Skin

Publications for Epithelioid Leiomyosarcoma

Articles related to Epithelioid Leiomyosarcoma:

(show top 50) (show all 70)
# Title Authors Year
1
PGR Gene Fusions Identify a Molecular Subset of Uterine Epithelioid Leiomyosarcoma With Rhabdoid Features. ( 30829727 )
2019
2
Uterine epithelioid leiomyosarcoma with c-kit expression and YWHAE gene rearrangement: a case report of a diagnostic pitfall of uterine sarcoma. ( 28288693 )
2017
3
Epithelioid leiomyosarcoma arising in the subcutis--a new case report of a rare variant. ( 23739249 )
2014
4
Cardiac epithelioid leiomyosarcoma as both intracardiac and pericardial mass with massive pericardial effusion: a rare presentation. ( 23916929 )
2013
5
Epithelioid leiomyosarcoma of uterus. ( 22602833 )
2012
6
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. ( 21410837 )
2011
7
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. ( 21440979 )
2011
8
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. ( 21574810 )
2011
9
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. ( 19952934 )
2010
10
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. ( 20552587 )
2010
11
Epithelioid leiomyosarcoma of the uterus: computed tomography findings. ( 20882890 )
2010
12
Epithelioid leiomyosarcoma with rhabdoid features. ( 17943409 )
2007
13
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). ( 15690961 )
2005
14
Epithelioid leiomyosarcoma of the ovary. ( 15863185 )
2005
15
Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature. ( 15890394 )
2005
16
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. ( 16094142 )
2005
17
Epithelioid leiomyosarcoma: case report and review of the literature. ( 16409271 )
2005
18
Epithelioid leiomyosarcoma of the gastrocolic ligament. ( 12658888 )
2003
19
Epithelioid leiomyosarcoma of the external deep soft tissue. ( 12683863 )
2003
20
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. ( 12683897 )
2003
21
Primary paratesticular epithelioid leiomyosarcoma. ( 12740499 )
2003
22
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. ( 14632734 )
2003
23
Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. ( 11831608 )
2002
24
Epithelioid leiomyosarcoma of the external deep soft tissue. ( 11900575 )
2002
25
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. ( 12232582 )
2002
26
Epithelioid leiomyosarcoma of the uterine cervix. ( 11531304 )
2001
27
Epithelioid leiomyosarcoma of the uterus with oncocytic change. ( 11569929 )
2001
28
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. ( 10705403 )
2000
29
Epithelioid leiomyosarcoma of the stomach: report of a case. ( 10714261 )
2000
30
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. ( 10899680 )
2000
31
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". ( 11048812 )
2000
32
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. ( 10053121 )
1999
33
Primary epithelioid leiomyosarcoma of bone. Case report and literature review. ( 10335949 )
1999
34
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. ( 10588354 )
1999
35
Epithelioid leiomyosarcoma of the uterine cervix. ( 9512340 )
1998
36
Epithelioid leiomyosarcoma of the skin. ( 9563281 )
1998
37
Epithelioid leiomyosarcoma of the larynx. ( 9702545 )
1998
38
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. ( 9726062 )
1998
39
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. ( 9870863 )
1998
40
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. ( 9390146 )
1997
41
Malignant plexiform tumor of the uterus: an unusual variant of epithelioid leiomyosarcoma. ( 8910640 )
1996
42
Primary multiple epithelioid leiomyosarcoma of the liver. ( 8975973 )
1996
43
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. ( 9029402 )
1996
44
Gastric stump carcinoma occurring in a patient with Carney's triad 38 years after partial gastrectomy for epithelioid leiomyosarcoma. ( 7864713 )
1995
45
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. ( 7959652 )
1994
46
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. ( 8116792 )
1994
47
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. ( 8203266 )
1994
48
Epithelioid leiomyosarcoma of the breast: report of a case. ( 8104588 )
1993
49
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. ( 8253608 )
1993
50
Epithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literature. ( 8336232 )
1993

Variations for Epithelioid Leiomyosarcoma

Expression for Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for Epithelioid Leiomyosarcoma

Pathways related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 ACTC1 DES VIM
2
Show member pathways
11.29 DES VIM
3
Show member pathways
10.81 DES VIM
4 10.66 ACTC1 DES VIM

GO Terms for Epithelioid Leiomyosarcoma

Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.13 ACTC1 PTPRC VIM
2 extracellular exosome GO:0070062 9.1 ACTC1 DES ENO2 PTPRC SERPINA3 VIM

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.96 DES VIM
2 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES VIM

Sources for Epithelioid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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