MCID: EPT011
MIFTS: 29

Epithelioid Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Epithelioid Leiomyosarcoma

MalaCards integrated aliases for Epithelioid Leiomyosarcoma:

Name: Epithelioid Leiomyosarcoma 12 15
Leiomyosarcoma, Epithelioid 70
Leiomyosarcoma Epithelioid 54

Classifications:



External Ids:

Disease Ontology 12 DOID:5264
MeSH 44 D007890
NCIt 50 C3700
SNOMED-CT 67 42392001
UMLS 70 C0205815

Summaries for Epithelioid Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is composed predominantly or entirely of round or polygonal cells with eosinophilic, or much less commonly, clear cytoplasm.

MalaCards based summary : Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to rare tumor and intravenous leiomyomatosis. An important gene associated with Epithelioid Leiomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. Affiliated tissues include breast, uterus and smooth muscle, and related phenotypes are cardiovascular system and cellular

Related Diseases for Epithelioid Leiomyosarcoma

Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
# Related Disease Score Top Affiliating Genes
1 rare tumor 30.7 DES ACTC1
2 intravenous leiomyomatosis 30.1 PGR DES
3 leiomyoma 29.9 VIM PGR DES ACTC1
4 cutaneous leiomyosarcoma 29.9 VIM MUC1 DES ACTC1
5 uterus leiomyosarcoma 29.8 PGR ENO2
6 small cell carcinoma 29.8 PTPRC MUC1 ENO2
7 hemangioblastoma 29.8 VIM MUC1 ENO2
8 smooth muscle tumor 29.7 VIM SERPINA3 PGR DES ACTC1
9 breast leiomyosarcoma 29.7 MB ENO2
10 gastrointestinal stromal tumor 29.5 VIM ENO2 DES ACTC1
11 spindle cell sarcoma 29.4 VIM SERPINA3 MUC1 DES ACTC1
12 rhabdoid cancer 29.3 VIM SERPINA3 PTPRC MUC1 DES ACTC1
13 leiomyosarcoma 29.2 VIM SERPINA3 PGR MUC1 MB ENO2
14 endometrial stromal sarcoma 29.0 VIM PGR MB DES ACTC1
15 rhabdomyosarcoma 28.6 VIM PTPRC MB ENO2 DES ACTC1
16 uterine corpus epithelioid leiomyosarcoma 11.3
17 conventional leiomyosarcoma 11.1
18 infantile digital fibromatosis 10.3 VIM DES
19 malignant fibrous histiocytoma of bone 10.3 SERPINA3 DES
20 multicentric reticulohistiocytosis 10.3 VIM SERPINA3
21 heart lymphoma 10.3 VIM PTPRC
22 ovarian mucinous cystadenocarcinoma 10.3 VIM SERPINA3
23 retroperitoneal fibrosis 10.3 VIM PTPRC
24 odontogenic myxoma 10.3 VIM SERPINA3
25 nodular hidradenoma 10.3 VIM MUC1
26 fibroblastic rheumatism 10.3 DES ACTC1
27 hidradenoma 10.3 VIM MUC1
28 ovarian fibrothecoma 10.3 DES ACTC1
29 paraganglioma 10.2
30 chondroma 10.2
31 lymphangiectasis 10.2 VIM ACTC1
32 bladder small cell carcinoma 10.2 PTPRC MUC1
33 glomangiomyoma 10.2 VIM ACTC1
34 pulmonary vein stenosis 10.2 DES ACTC1
35 histiocytic and dendritic cell cancer 10.2 SERPINA3 PTPRC
36 pericardial mesothelioma 10.2 VIM MUC1
37 gingival hypertrophy 10.2 VIM SERPINA3
38 lipoadenoma 10.2 SERPINA3 MUC1
39 chordoid meningioma 10.2 VIM MUC1
40 anaplastic ependymoma 10.2 VIM MUC1
41 primary cutaneous anaplastic large cell lymphoma 10.2 PTPRC MUC1
42 angiocentric glioma 10.2 VIM ACTC1
43 eccrine porocarcinoma 10.2 VIM MUC1
44 ovarian benign neoplasm 10.2 MUC1 DES
45 bile duct adenoma 10.2 VIM MUC1
46 scrotum neoplasm 10.2 SERPINA3 ACTC1
47 bednar tumor 10.2 VIM ENO2
48 fibrous meningioma 10.2 VIM MUC1
49 proximal spinal muscular atrophy 10.2 MUC1 DES
50 monophasic synovial sarcoma 10.2 VIM MUC1

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to Epithelioid Leiomyosarcoma

Symptoms & Phenotypes for Epithelioid Leiomyosarcoma

MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 ACTC1 DES MB PGR PTHLH PTPRC
2 cellular MP:0005384 9.23 ACTC1 DES ENO2 MB PGR PTHLH

Drugs & Therapeutics for Epithelioid Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

Anatomical Context for Epithelioid Leiomyosarcoma

MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

40
Breast, Uterus, Smooth Muscle, Ovary, Cervix, Bone, Kidney

Publications for Epithelioid Leiomyosarcoma

Articles related to Epithelioid Leiomyosarcoma:

(show top 50) (show all 147)
# Title Authors PMID Year
1
Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature. 54 61
15890394 2005
2
A uterine leiomyosarcoma that became positive for HMB45 in the metastasis. 54 61
15692950 2005
3
Recent advances in smooth muscle tumors with PGR and PLAG1 gene fusions and myofibroblastic uterine neoplasms. 61
33230916 2021
4
[Uterine malignant perivascular epithelioid cell tumor (PEComa): Two case reports]. 61
32646778 2021
5
Malignant Epithelioid Soft Tissue Tumours- A Pathologist's Perspective With Review of Literature. 61
33520482 2020
6
Evaluation of a Lung Nodule in the Setting of Metastatic Gastrointestinal Stromal Tumor: Surgical Considerations in Carney's Triad. 61
32399353 2020
7
Uterine lesions with sex cord-like architectures: a systematic review. 61
31739799 2019
8
Characteristics of mismatch repair deficiency in sarcomas. 61
30765880 2019
9
PGR Gene Fusions Identify a Molecular Subset of Uterine Epithelioid Leiomyosarcoma With Rhabdoid Features. 61
30829727 2019
10
Misdiagnosis of Leiomyosarcoma after Radiofrequency Ablation of Uterine Myomas. 61
30121386 2019
11
Secondary Leiomyosarcoma of the Lower Limb Following Uterine Smooth Muscle Tumor of Uncertain Malignant Potential. 61
31258342 2019
12
Retroperitoneal leiomyosarcoma mimicking gastric cancer recurrence: A case report. 61
31669956 2019
13
Uterine epithelioid leiomyosarcoma with c-kit expression and YWHAE gene rearrangement: a case report of a diagnostic pitfall of uterine sarcoma. 61
28288693 2017
14
Long-term response to first-line trabectedin in an elderly female patient with a metastatic leiomyosarcoma unfit for anthracycline. 61
26629769 2016
15
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2. 61
25816393 2015
16
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1. 61
25816394 2015
17
Epithelioid leiomyosarcoma arising in the subcutis--a new case report of a rare variant. 61
23739249 2014
18
Cardiac epithelioid leiomyosarcoma as both intracardiac and pericardial mass with massive pericardial effusion: a rare presentation. 61
23916929 2013
19
Epithelioid leiomyosarcoma of uterus. 61
22602833 2012
20
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. 61
21440979 2011
21
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. 61
21410837 2011
22
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. 61
21574810 2011
23
Pseudo-Meigs' syndrome caused by a uterine leiomyosarcoma: a new clinical condition. 61
21625074 2011
24
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. 61
20552587 2010
25
Epithelioid leiomyosarcoma of the uterus: computed tomography findings. 61
20882890 2010
26
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. 61
19952934 2010
27
Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. 61
19935059 2010
28
Epithelioid smooth muscle tumors of the uterus do not express CD1a: a potential immunohistochemical adjunct in their distinction from uterine perivascular epithelioid cell tumors. 61
18995203 2008
29
[Epithelioid leiomyosarcoma of the uterine cervix: two cases]. 61
19166150 2007
30
Spindle cell tumor with EWS-WT1 transcript and a favorable clinical course: a variant of DSCT, a variant of leiomyosarcoma, or a new entity? Report of 2 pediatric cases. 61
17325488 2007
31
Epithelioid leiomyosarcoma with rhabdoid features. 61
17943409 2007
32
Epithelioid leiomyosarcoma: case report and review of the literature. 61
16409271 2005
33
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. 61
16094142 2005
34
Epithelioid leiomyosarcoma of the ovary. 61
15863185 2005
35
Laparoscopy for the definitive diagnosis of intra-abdominal lymphoma. 61
15887430 2005
36
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). 61
15690961 2005
37
Massive cardiac chondroma presenting with heart failure and superior vena cava obstruction in a teenage boy. 61
16137169 2004
38
Placental site trophoblastic tumor in a postmenopausal female--a case report. 61
15099979 2004
39
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. 54
15043315 2004
40
Leiomyosarcoma of the cervix. 61
14675691 2003
41
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. 61
14632734 2003
42
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. 61
12683897 2003
43
Epithelioid leiomyosarcoma of the external deep soft tissue. 61
12683863 2003
44
[Epithelioid bilateral ovarian leiomyosarcoma: a study]. 61
12743499 2003
45
Epithelioid leiomyosarcoma of the gastrocolic ligament. 61
12658888 2003
46
Primary paratesticular epithelioid leiomyosarcoma. 61
12740499 2003
47
[Stromal tumors of the rectum: a case report and review of the literature]. 61
12469469 2002
48
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. 61
12232582 2002
49
[Epithelial leiomyosarcoma of gingiva: a case report and review of literature]. 61
12068478 2002
50
Epithelioid leiomyosarcoma of the external deep soft tissue. 61
11900575 2002

Variations for Epithelioid Leiomyosarcoma

Expression for Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for Epithelioid Leiomyosarcoma

Pathways related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 VIM MUC1 DES ACTC1
2 10.66 VIM DES ACTC1

GO Terms for Epithelioid Leiomyosarcoma

Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 VIM SERPINA3 PTPRC MUC1 MB ENO2

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.96 VIM DES
2 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Sources for Epithelioid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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