MCID: EPT003
MIFTS: 33

Epithelioid Trophoblastic Tumor

Categories: Reproductive diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Epithelioid Trophoblastic Tumor

MalaCards integrated aliases for Epithelioid Trophoblastic Tumor:

Name: Epithelioid Trophoblastic Tumor 12 59 15
Trophoblastic Tumor, Epithelioid 73

Characteristics:

Orphanet epidemiological data:

59
epithelioid trophoblastic tumor
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3593
NCIt 50 C6900
SNOMED-CT 68 128767001 609515005
Orphanet 59 ORPHA254698
ICD10 via Orphanet 34 D39.2
UMLS via Orphanet 74 C1266159
UMLS 73 C1266159

Summaries for Epithelioid Trophoblastic Tumor

MalaCards based summary : Epithelioid Trophoblastic Tumor, also known as trophoblastic tumor, epithelioid, is related to trophoblastic neoplasm and choriocarcinoma. An important gene associated with Epithelioid Trophoblastic Tumor is KRT18 (Keratin 18), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and placenta.

Related Diseases for Epithelioid Trophoblastic Tumor

Diseases related to Epithelioid Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 trophoblastic neoplasm 31.6 CSH1 INHA
2 choriocarcinoma 30.1 CGB3 CSH1
3 placental site trophoblastic tumor 28.5 CGB3 CSH1 INHA SALL4
4 gestational trophoblastic tumor 11.7
5 cystadenofibroma 10.1 INHA KRT7
6 granulosa cell tumor of the ovary 10.1 INHA KRT7
7 cystadenoma 10.1 INHA KRT7
8 proliferating trichilemmal cyst 10.1 KRT18 KRT7
9 cutaneous adenocystic carcinoma 10.1 KRT18 KRT7
10 choriocarcinoma of the testis 10.0 CSH1 KRT7
11 metanephric adenoma 10.0 KRT18 KRT7
12 seminal vesicle tumor 10.0 KRT18 KRT7
13 sex cord-gonadal stromal tumor 10.0 INHA KRT7
14 pleomorphic carcinoma 10.0 KRT18 KRT7
15 mucinous tubular and spindle renal cell carcinoma 10.0 KRT18 KRT7
16 squamous cell carcinoma 10.0
17 cervicitis 10.0
18 adenocarcinoma 10.0
19 gestational trophoblastic neoplasm 10.0
20 germ cells tumors 10.0
21 mixed germ cell tumor 10.0
22 placenta disease 10.0 CGB3 CSH1
23 lymphoepithelioma-like carcinoma 10.0 KRT18 KRT7
24 seminoma 10.0 CGB3 INHA
25 mammary paget's disease 10.0 KRT18 KRT7
26 intraneural perineurioma 10.0 KRT18 KRT7
27 nephrogenic adenofibroma 10.0 KRT18 KRT7
28 germ cell and embryonal cancer 9.9 CSH1 KRT7
29 small cell cancer of the lung 9.9
30 lung cancer 9.9
31 hydatidiform mole, recurrent, 1 9.9
32 cervical cancer 9.9
33 ectopic pregnancy 9.9
34 mucinous adenocarcinoma 9.9
35 embryonal carcinoma 9.9
36 primary cutaneous amyloidosis 9.9 KRT18 KRT7
37 adenosquamous carcinoma 9.8 KRT18 KRT7
38 teratoma 9.8 CGB3 KRT7
39 oncocytoma 9.8 KRT18 KRT7
40 robinow syndrome, autosomal recessive 9.8 INHA SALL4
41 chromophobe renal cell carcinoma 9.8 KRT18 KRT7
42 ovarian germ cell cancer 9.7 KRT7 SALL4
43 ovarian endodermal sinus tumor 9.7 KRT7 SALL4
44 ovarian primitive germ cell tumor 9.6 KRT7 SALL4
45 epithelioid sarcoma 9.6 KRT7 SALL4
46 transitional cell carcinoma 9.5 KRT18 KRT7
47 clear cell renal cell carcinoma 9.4 INHA KRT7
48 endodermal sinus tumor 9.2 CGB3 KRT7 SALL4
49 ovarian brenner tumor 9.1 KRT18 KRT7 SALL4

Graphical network of the top 20 diseases related to Epithelioid Trophoblastic Tumor:



Diseases related to Epithelioid Trophoblastic Tumor

Symptoms & Phenotypes for Epithelioid Trophoblastic Tumor

Drugs & Therapeutics for Epithelioid Trophoblastic Tumor

Drugs for Epithelioid Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
2
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 2, Phase 3,Phase 3 58-05-9 143 6006
5 Antidotes Phase 2, Phase 3
6 Antimetabolites Phase 2, Phase 3
7 Antimetabolites, Antineoplastic Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Folic Acid Antagonists Phase 2, Phase 3
11 Hematinics Phase 2, Phase 3
12 Immunosuppressive Agents Phase 2, Phase 3
13 Micronutrients Phase 2, Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
15 Protective Agents Phase 2, Phase 3
16 Trace Elements Phase 2, Phase 3
17 Vitamin B Complex Phase 2, Phase 3
18 Vitamins Phase 2, Phase 3
19 Folate Nutraceutical Phase 2, Phase 3
20 Vitamin B9 Nutraceutical Phase 2, Phase 3
21
Bevacizumab Approved, Investigational Phase 2 216974-75-3
22
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
23 Angiogenesis Inhibitors Phase 2
24 Angiogenesis Modulating Agents Phase 2
25 Antibodies Phase 2
26 Antibodies, Monoclonal Phase 2
27 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
4 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Epithelioid Trophoblastic Tumor

Genetic Tests for Epithelioid Trophoblastic Tumor

Anatomical Context for Epithelioid Trophoblastic Tumor

MalaCards organs/tissues related to Epithelioid Trophoblastic Tumor:

41
Lung, Uterus, Placenta, Cervix, Ovary, Breast, Testis

Publications for Epithelioid Trophoblastic Tumor

Articles related to Epithelioid Trophoblastic Tumor:

(show top 50) (show all 77)
# Title Authors Year
1
Imaging of Metastatic Epithelioid Trophoblastic Tumor With 18F-FDG PET/CT. ( 29659388 )
2018
2
Laparoscopic diagnosis and treatment of an isolated epithelioid trophoblastic tumor in recto-uterine pouch. ( 29436119 )
2018
3
Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor. ( 29757875 )
2018
4
Metastatic epithelioid trophoblastic tumor of the lung: A case report. ( 29668580 )
2018
5
Epithelioid Trophoblastic Tumor Around an Abdominal Cesarean Scar: A Pathologic and Molecular Genetic Analysis. ( 28134666 )
2017
6
Epithelioid trophoblastic tumor of the uterus: A case report with radiologic-pathologic correlation. ( 28548328 )
2017
7
Diagnosing and treating rare lesions in a low resource setting: lessons from ahybrid epithelioid trophoblastic tumor and choriocarcinoma. ( 29622835 )
2017
8
Comparison of p63 and p40 Immunohistochemical Stains to Distinguish Epithelioid Trophoblastic Tumor From Other Trophoblastic Lesions. ( 28700434 )
2017
9
Sonographic image of cervix epithelioid trophoblastic tumor coexisting with mucinous adenocarcinoma in a postmenopausal woman: A case report. ( 28930821 )
2017
10
Extrauterine epithelioid trophoblastic tumor in hysterectomized woman. ( 28217684 )
2017
11
Epithelioid trophoblastic tumor: a case report and literature review. ( 28174805 )
2016
12
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
13
Epithelioid Trophoblastic Tumor in a Postmenopausal Woman: A Case Report. ( 27152314 )
2016
14
MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report. ( 27001388 )
2016
15
Microsatellite Genotyping to Distinguish Somatic I^-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor. ( 25960907 )
2015
16
Choriocarcinoma coexisting with epithelioid trophoblastic tumor of the uterine horn. ( 26793769 )
2015
17
Clinicopathologic Analysis of Postchemotherapy Gestational Trophoblastic Neoplasia: An Entity Overlapping With Epithelioid Trophoblastic Tumor. ( 26630228 )
2015
18
Extrauterine Epithelioid Trophoblastic Tumor Arising in the Ovary With Multiple Metastases: A Case Report. ( 25695493 )
2015
19
Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center. ( 25773203 )
2015
20
An incidentally diagnosed epithelioid trophoblastic tumor in hysterectomy. ( 26946877 )
2015
21
Epithelioid trophoblastic tumor. ( 26522123 )
2015
22
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
23
Diagnostic challenges in cornual epithelioid trophoblastic tumor. ( 25017275 )
2014
24
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
25
Epithelioid trophoblastic tumor presenting as an ovarian mass in a postmenopausal woman. ( 24300533 )
2014
26
Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature. ( 25550880 )
2014
27
Extragestational I^HCG secretion due to an isolated lung epithelioid trophoblastic tumor: microsatellite genotyping of tumoral cells confirmed their placental origin and oriented specific chemotherapy. ( 25029419 )
2014
28
Epithelioid trophoblastic tumor: an unusual malignancy of ovary. ( 25518773 )
2014
29
Metastatic epithelioid trophoblastic tumor: a rare case report. ( 24966508 )
2014
30
Primary epithelioid trophoblastic tumor of the lung. ( 24694417 )
2014
31
Epithelioid trophoblastic tumor: report of two cases in postmenopausal women with literature review and emphasis on cytological findings. ( 24525845 )
2014
32
Epithelioid trophoblastic tumor: an outcome-based literature review of 78 reported cases. ( 23970158 )
2013
33
Pulmonary mass diagnosed as extrauterine epithelioid trophoblastic tumor. ( 23307273 )
2013
34
Extrauterine Epithelioid Trophoblastic Tumor of Lung in a 35-year-old Woman. ( 24368977 )
2013
35
Epithelioid trophoblastic tumor: clinicopathologic and immunohistochemical analysis of three cases. ( 23483773 )
2013
36
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
37
Isolated epithelioid trophoblastic tumor of the vagina: a case report and review of the literature. ( 24194644 )
2013
38
Epithelioid trophoblastic tumor: a case report and review of the literature. ( 23243530 )
2012
39
Combined epithelioid trophoblastic tumor and contralateral synchronous adenocarcinoma of the lungs in a 69-year-old man. ( 23180430 )
2012
40
Primary epithelioid trophoblastic tumor with a synchronous breast carcinoma detected only with FDG-PET/CT Scan. ( 21440960 )
2011
41
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. ( 21519041 )
2011
42
Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases. ( 20087692 )
2011
43
Ovarian involvement of epithelioid trophoblastic tumor: a case report. ( 21293282 )
2011
44
Epithelioid trophoblastic tumor and its diagnostic dilemmas: A rare case report. ( 24371611 )
2011
45
Differentiating squamous cell carcinoma of the cervix and epithelioid trophoblastic tumor. ( 21697681 )
2011
46
Analysis of clinicopathologic prognostic factors in 9 patients with epithelioid trophoblastic tumor. ( 21738043 )
2011
47
Isolated epithelioid trophoblastic tumor mimicking non-small cell lung cancer. ( 21623270 )
2011
48
Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor. ( 20069561 )
2010
49
Epithelioid trophoblastic tumor masquerading as invasive squamous cell carcinoma of the cervix after an ectopic pregnancy. ( 20223511 )
2010
50
Cytologic findings of epithelioid trophoblastic tumor of the uterus: a case report. ( 20518425 )
2010

Variations for Epithelioid Trophoblastic Tumor

Expression for Epithelioid Trophoblastic Tumor

Search GEO for disease gene expression data for Epithelioid Trophoblastic Tumor.

Pathways for Epithelioid Trophoblastic Tumor

Pathways related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT18 KRT7

GO Terms for Epithelioid Trophoblastic Tumor

Cellular components related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.62 KRT18 KRT7

Biological processes related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.96 KRT18 KRT7
2 regulation of signaling receptor activity GO:0010469 8.8 CGB3 CSH1 INHA

Molecular functions related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CGB3 CSH1 INHA

Sources for Epithelioid Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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