MCID: EPT003
MIFTS: 34

Epithelioid Trophoblastic Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Epithelioid Trophoblastic Tumor

MalaCards integrated aliases for Epithelioid Trophoblastic Tumor:

Name: Epithelioid Trophoblastic Tumor 12 60 15
Trophoblastic Tumor, Epithelioid 74

Characteristics:

Orphanet epidemiological data:

60
epithelioid trophoblastic tumor
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3593
NCIt 51 C6900
ICD10 via Orphanet 35 D39.2
UMLS via Orphanet 75 C1266159
Orphanet 60 ORPHA254698
UMLS 74 C1266159

Summaries for Epithelioid Trophoblastic Tumor

MalaCards based summary : Epithelioid Trophoblastic Tumor, also known as trophoblastic tumor, epithelioid, is related to choriocarcinoma and trophoblastic neoplasm. An important gene associated with Epithelioid Trophoblastic Tumor is KRT18 (Keratin 18), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Epithelioid Trophoblastic Tumor

Diseases related to Epithelioid Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.9 CGB3 CSH1
2 trophoblastic neoplasm 30.2 CSH1 INHA
3 placental site trophoblastic tumor 29.7 CGB3 CSH1 INHA SALL4
4 small cell cancer of the lung 29.5 KRT18 KRT7
5 gestational trophoblastic tumor 11.9
6 squamous cell carcinoma 10.2
7 adenocarcinoma 10.2
8 germ cells tumors 10.2
9 mixed germ cell tumor 10.2
10 cystadenofibroma 10.0 INHA KRT7
11 granulosa cell tumor of the ovary 10.0 INHA KRT7
12 proliferating trichilemmal cyst 10.0 KRT18 KRT7
13 cervical cancer 10.0
14 ectopic pregnancy 10.0
15 mucinous adenocarcinoma 10.0
16 embryonal carcinoma 10.0
17 gestational trophoblastic neoplasm 10.0
18 appendix adenocarcinoma 10.0
19 hydatidiform mole, recurrent, 1 10.0
20 lung cancer 10.0
21 breast cancer 10.0
22 cutaneous adenocystic carcinoma 10.0 KRT18 KRT7
23 seminal vesicle tumor 10.0 KRT18 KRT7
24 choriocarcinoma of the testis 10.0 CSH1 KRT7
25 cystadenoma 10.0 INHA KRT7
26 metanephric adenoma 10.0 KRT18 KRT7
27 warthin tumor 10.0 KRT18 KRT7
28 placenta disease 10.0 CGB3 CSH1
29 mucinous tubular and spindle renal cell carcinoma 10.0 KRT18 KRT7
30 sex cord-gonadal stromal tumor 10.0 INHA KRT7
31 lymphoepithelioma-like carcinoma 10.0 KRT18 KRT7
32 intraneural perineurioma 10.0 KRT18 KRT7
33 nephrogenic adenofibroma 10.0 KRT18 KRT7
34 germ cell and embryonal cancer 10.0 CSH1 KRT7
35 seminoma 10.0 CGB3 INHA
36 primary cutaneous amyloidosis 9.9 KRT18 KRT7
37 endodermal sinus tumor 9.9 CGB3 SALL4
38 sweat gland cancer 9.9 KRT18 KRT7
39 oncocytoma 9.9 KRT18 KRT7
40 teratoma 9.9 CGB3 KRT7
41 chromophobe renal cell carcinoma 9.9 KRT18 KRT7
42 ovarian germ cell cancer 9.8 KRT7 SALL4
43 ovarian endodermal sinus tumor 9.8 KRT7 SALL4
44 ovarian primitive germ cell tumor 9.8 KRT7 SALL4
45 epithelioid sarcoma 9.8 KRT7 SALL4
46 transitional cell carcinoma 9.7 KRT18 KRT7
47 ovarian brenner tumor 9.5 KRT18 KRT7 SALL4

Graphical network of the top 20 diseases related to Epithelioid Trophoblastic Tumor:



Diseases related to Epithelioid Trophoblastic Tumor

Symptoms & Phenotypes for Epithelioid Trophoblastic Tumor

GenomeRNAi Phenotypes related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.28 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.28 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.28 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.28 KRT7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.28 KRT18 KRT7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.28 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.28 KRT18
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.28 KRT7

Drugs & Therapeutics for Epithelioid Trophoblastic Tumor

Drugs for Epithelioid Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 143 6006
2
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
3
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
5 Vitamin B9 Phase 2, Phase 3
6 Antimetabolites Phase 2, Phase 3
7 Trace Elements Phase 2, Phase 3
8 Hematinics Phase 2, Phase 3
9 Immunologic Factors Phase 2, Phase 3
10 Vitamin B Complex Phase 2, Phase 3
11 Vitamins Phase 2, Phase 3
12 Micronutrients Phase 2, Phase 3
13 Immunosuppressive Agents Phase 2, Phase 3
14 Antidotes Phase 2, Phase 3
15 Folic Acid Antagonists Phase 2, Phase 3
16 Dermatologic Agents Phase 2, Phase 3
17 Protective Agents Phase 2, Phase 3
18 Folate Phase 2, Phase 3
19 Antirheumatic Agents Phase 2, Phase 3
20 Nutrients Phase 2, Phase 3
21 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
22 Antimetabolites, Antineoplastic Phase 2, Phase 3
23
Bevacizumab Approved, Investigational Phase 2 216974-75-3
24
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
25 Antineoplastic Agents, Immunological Phase 2
26 Immunoglobulins Phase 2
27 Angiogenesis Modulating Agents Phase 2
28 Antibodies Phase 2
29 Angiogenesis Inhibitors Phase 2
30 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Terminated NCT02664961 Phase 2 TRC105;Bevacizumab
4 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Epithelioid Trophoblastic Tumor

Genetic Tests for Epithelioid Trophoblastic Tumor

Anatomical Context for Epithelioid Trophoblastic Tumor

MalaCards organs/tissues related to Epithelioid Trophoblastic Tumor:

42
Lung, Placenta, Ovary, Uterus, Breast, Testis, Cervix

Publications for Epithelioid Trophoblastic Tumor

Articles related to Epithelioid Trophoblastic Tumor:

(show top 50) (show all 77)
# Title Authors Year
1
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy. ( 31047719 )
2019
2
Comparison of p63 and p40 Immunohistochemical Stains to Distinguish Epithelioid Trophoblastic Tumor From Other Trophoblastic Lesions. ( 28700434 )
2018
3
Epithelioid Trophoblastic Tumor: Expanding the Clinicopathologic Spectrum of a Rare Malignancy. ( 30480644 )
2018
4
Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor. ( 29757875 )
2018
5
Metastatic epithelioid trophoblastic tumor of the lung: A case report. ( 29668580 )
2018
6
Imaging of Metastatic Epithelioid Trophoblastic Tumor With 18F-FDG PET/CT. ( 29659388 )
2018
7
Laparoscopic diagnosis and treatment of an isolated epithelioid trophoblastic tumor in recto-uterine pouch. ( 29436119 )
2018
8
Sonographic image of cervix epithelioid trophoblastic tumor coexisting with mucinous adenocarcinoma in a postmenopausal woman: A case report. ( 28930821 )
2017
9
Epithelioid trophoblastic tumor of the uterus: A case report with radiologic-pathologic correlation. ( 28548328 )
2017
10
Extrauterine epithelioid trophoblastic tumor in hysterectomized woman. ( 28217684 )
2017
11
Epithelioid Trophoblastic Tumor Around an Abdominal Cesarean Scar: A Pathologic and Molecular Genetic Analysis. ( 28134666 )
2017
12
Diagnosing and treating rare lesions in a low resource setting: lessons from ahybrid epithelioid trophoblastic tumor and choriocarcinoma. ( 29622835 )
2017
13
Epithelioid trophoblastic tumor: a case report and literature review. ( 28174805 )
2016
14
Epithelioid Trophoblastic Tumor in a Postmenopausal Woman: A Case Report. ( 27152314 )
2016
15
MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report. ( 27001388 )
2016
16
Clinicopathologic Analysis of Postchemotherapy Gestational Trophoblastic Neoplasia: An Entity Overlapping With Epithelioid Trophoblastic Tumor. ( 26630228 )
2016
17
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
18
Epithelioid trophoblastic tumor. ( 26522123 )
2015
19
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
20
Microsatellite Genotyping to Distinguish Somatic β-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor. ( 25960907 )
2015
21
Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center. ( 25773203 )
2015
22
Extrauterine epithelioid trophoblastic tumor arising in the ovary with multiple metastases: a case report. ( 25695493 )
2015
23
An incidentally diagnosed epithelioid trophoblastic tumor in hysterectomy. ( 26946877 )
2015
24
Choriocarcinoma coexisting with epithelioid trophoblastic tumor of the uterine horn. ( 26793769 )
2015
25
Epithelioid trophoblastic tumor: an unusual malignancy of ovary. ( 25518773 )
2014
26
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
27
Extragestational βHCG secretion due to an isolated lung epithelioid trophoblastic tumor: microsatellite genotyping of tumoral cells confirmed their placental origin and oriented specific chemotherapy. ( 25029419 )
2014
28
Diagnostic challenges in cornual epithelioid trophoblastic tumor. ( 25017275 )
2014
29
Metastatic epithelioid trophoblastic tumor: a rare case report. ( 24966508 )
2014
30
Primary epithelioid trophoblastic tumor of the lung. ( 24694417 )
2014
31
Epithelioid trophoblastic tumor: report of two cases in postmenopausal women with literature review and emphasis on cytological findings. ( 24525845 )
2014
32
Epithelioid trophoblastic tumor presenting as an ovarian mass in a postmenopausal woman. ( 24300533 )
2014
33
Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature. ( 25550880 )
2014
34
Extrauterine Epithelioid Trophoblastic Tumor of Lung in a 35-year-old Woman. ( 24368977 )
2013
35
Isolated epithelioid trophoblastic tumor of the vagina: a case report and review of the literature. ( 24194644 )
2013
36
Epithelioid trophoblastic tumor: an outcome-based literature review of 78 reported cases. ( 23970158 )
2013
37
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
38
Epithelioid trophoblastic tumor: clinicopathologic and immunohistochemical analysis of three cases. ( 23483773 )
2013
39
Pulmonary mass diagnosed as extrauterine epithelioid trophoblastic tumor. ( 23307273 )
2013
40
Epithelioid trophoblastic tumor: a case report and review of the literature. ( 23243530 )
2012
41
Combined epithelioid trophoblastic tumor and contralateral synchronous adenocarcinoma of the lungs in a 69-year-old man. ( 23180430 )
2012
42
Epithelioid trophoblastic tumor and its diagnostic dilemmas: A rare case report. ( 24371611 )
2011
43
Analysis of clinicopathologic prognostic factors in 9 patients with epithelioid trophoblastic tumor. ( 21738043 )
2011
44
Differentiating squamous cell carcinoma of the cervix and epithelioid trophoblastic tumor. ( 21697681 )
2011
45
Isolated epithelioid trophoblastic tumor mimicking non-small cell lung cancer. ( 21623270 )
2011
46
Primary epithelioid trophoblastic tumor with a synchronous breast carcinoma detected only with FDG-PET/CT Scan. ( 21440960 )
2011
47
Ovarian involvement of epithelioid trophoblastic tumor: a case report. ( 21293282 )
2011
48
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. ( 21519041 )
2011
49
Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases. ( 20087692 )
2011
50
Epithelioid trophoblastic tumor masquerading as invasive squamous cell carcinoma of the cervix after an ectopic pregnancy. ( 20223511 )
2010

Variations for Epithelioid Trophoblastic Tumor

Expression for Epithelioid Trophoblastic Tumor

Search GEO for disease gene expression data for Epithelioid Trophoblastic Tumor.

Pathways for Epithelioid Trophoblastic Tumor

Pathways related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT18 KRT7

GO Terms for Epithelioid Trophoblastic Tumor

Cellular components related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.62 KRT18 KRT7

Biological processes related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.96 KRT18 KRT7
2 regulation of signaling receptor activity GO:0010469 8.8 CSH1 CGB3 INHA

Molecular functions related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CGB3 CSH1 INHA

Sources for Epithelioid Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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