MCID: EPT003
MIFTS: 29

Epithelioid Trophoblastic Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Epithelioid Trophoblastic Tumor

MalaCards integrated aliases for Epithelioid Trophoblastic Tumor:

Name: Epithelioid Trophoblastic Tumor 12 58 15
Trophoblastic Tumor, Epithelioid 70

Characteristics:

Orphanet epidemiological data:

58
epithelioid trophoblastic tumor
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3593
NCIt 50 C6900
SNOMED-CT 67 128767001
ICD10 via Orphanet 33 D39.2
UMLS via Orphanet 71 C1266159
Orphanet 58 ORPHA254698
UMLS 70 C1266159

Summaries for Epithelioid Trophoblastic Tumor

MalaCards based summary : Epithelioid Trophoblastic Tumor, also known as trophoblastic tumor, epithelioid, is related to gestational trophoblastic neoplasm and hydatidiform mole, recurrent, 1. An important gene associated with Epithelioid Trophoblastic Tumor is KRT18 (Keratin 18), and among its related pathways/superpathways is Cytoskeletal Signaling. Affiliated tissues include placenta, ovary and lung.

Related Diseases for Epithelioid Trophoblastic Tumor

Diseases related to Epithelioid Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 gestational trophoblastic neoplasm 31.2 LGALS1 CSH2 CSH1 CGB3
2 hydatidiform mole, recurrent, 1 30.9 INHA CGB3
3 choriocarcinoma 30.6 CSH2 CSH1 CGB3
4 trophoblastic neoplasm 30.5 LGALS1 INHA CSH2 CSH1 CGB3
5 ectopic pregnancy 30.3 MUC1 LGALS1 CGB3
6 teratoma 29.9 KRT7 KRT18 CGB3 ACTC1
7 placental site trophoblastic tumor 29.5 SALL4 LGALS1 INHA CSH2 CSH1 CGB3
8 rare tumor 10.4
9 proliferating trichilemmal cyst 10.3 KRT7 KRT18
10 intrahepatic gall duct cancer 10.3 KRT7 KRT18
11 lung clear cell carcinoma 10.3 KRT7 KRT18
12 squamous cell bile duct carcinoma 10.3 KRT7 KRT18
13 suppressor of tumorigenicity 3 10.3
14 amenorrhea 10.3
15 esophageal adenosquamous carcinoma 10.3 KRT7 KRT18
16 cutaneous adenocystic carcinoma 10.3 KRT7 KRT18
17 central epithelioid sarcoma 10.3 KRT7 KRT18
18 vulvar proximal-type epithelioid sarcoma 10.3 KRT7 KRT18
19 ovarian primitive germ cell tumor 10.3 SALL4 KRT7
20 ovarian endodermal sinus tumor 10.3 SALL4 KRT7
21 eccrine papillary adenoma 10.2 KRT7 KRT18
22 seminal vesicle adenocarcinoma 10.2 KRT7 KRT18
23 bladder sarcoma 10.2 KRT7 KRT18
24 ovarian germ cell cancer 10.2 SALL4 KRT7
25 bowen's disease 10.2 MKI67 KRT7
26 pleomorphic carcinoma 10.2 KRT7 KRT18
27 scrotum paget's disease 10.2 MUC1 KRT7
28 gallbladder signet ring cell adenocarcinoma 10.2 MUC1 KRT7
29 signet ring cell adenocarcinoma 10.2 MUC1 KRT7
30 horseshoe kidney 10.2 KRT7 ACTC1
31 mature teratoma 10.2 SALL4 KRT7
32 squamous cell carcinoma 10.2
33 germ cells tumors 10.2
34 mixed germ cell tumor 10.2
35 invasive mole 10.2
36 pancreatic foamy gland adenocarcinoma 10.2 MUC1 KRT7
37 urinary bladder villous adenoma 10.2 MUC1 KRT7
38 villous adenoma 10.2 MUC1 KRT7
39 bladder adenocarcinoma 10.2 MKI67 KRT7
40 mucinous intrahepatic cholangiocarcinoma 10.2 MUC1 KRT7
41 middle ear adenoma 10.2 MUC1 KRT7
42 bile duct cystadenocarcinoma 10.2 MUC1 KRT7
43 colonic lymphangioma 10.2 MUC1 KRT7
44 pulmonary vein stenosis 10.2 MKI67 ACTC1
45 biliary papillomatosis 10.2 MUC1 KRT7
46 bile duct mucoepidermoid carcinoma 10.2 MUC1 KRT7
47 lipoadenoma 10.2 MUC1 KRT7
48 ovarian small cell carcinoma 10.2 MUC1 INHA
49 glandular cystitis 10.2 MUC1 KRT7
50 pancreatic mucinous cystadenoma 10.2 MUC1 KRT7

Graphical network of the top 20 diseases related to Epithelioid Trophoblastic Tumor:



Diseases related to Epithelioid Trophoblastic Tumor

Symptoms & Phenotypes for Epithelioid Trophoblastic Tumor

Drugs & Therapeutics for Epithelioid Trophoblastic Tumor

Search Clinical Trials , NIH Clinical Center for Epithelioid Trophoblastic Tumor

Genetic Tests for Epithelioid Trophoblastic Tumor

Anatomical Context for Epithelioid Trophoblastic Tumor

MalaCards organs/tissues related to Epithelioid Trophoblastic Tumor:

40
Placenta, Ovary, Lung, Appendix, Uterus, Testis, Kidney

Publications for Epithelioid Trophoblastic Tumor

Articles related to Epithelioid Trophoblastic Tumor:

(show top 50) (show all 159)
# Title Authors PMID Year
1
Epithelioid trophoblastic tumor presenting as a Caesarean scar defect: A case report. 61
33604444 2021
2
Fertility and pregnancy outcome in gestational trophoblastic disease. 61
33649007 2021
3
Gestational trophoblastic neoplasia: Novelties and challenges. 61
33685753 2021
4
Clinical presentation and diagnosis of Gestational Trophoblastic Disease. 61
33422446 2020
5
Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature. 61
33012293 2020
6
Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report. 61
33078754 2020
7
Epithelioid trophoblastic tumor that requires fertility preservation: A case report and review of literature. 61
32917327 2020
8
[Preliminary study of PD-1 inhibitor in the treatment of drug-resistant recurrent gestational trophoblastic neoplasia]. 61
32842245 2020
9
A Rare Case of Atypical Placental Site Nodule With an Emerging Intermediate Trophoblastic Tumor. 61
30829757 2020
10
Whole transcriptome analysis of gestational trophoblastic neoplasms reveals altered PI3K signaling pathway in epithelioid trophoblastic tumor. 61
31954539 2020
11
Ovarian Intermediate Trophoblastic Tumors: Genotyping Defines a Distinct Category of Nongestational Tumors of Germ Cell Type. 61
31688005 2020
12
A review on management of gestational trophoblastic neoplasia. 61
32509606 2020
13
Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group. 61
32108639 2020
14
Epithelioid Trophoblastic Tumor: Expanding the Clinicopathologic Spectrum of a Rare Malignancy. 61
30480644 2020
15
Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor. 61
31735008 2019
16
Clinical characteristics and outcomes of extrauterine epithelioid trophoblastic tumors. 61
31312959 2019
17
Laterally Extended Endopelvic Resection of Recurrent Epithelioid Trophoblastic Tumor by Laparoscopy. 61
31125723 2019
18
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy. 61
31047719 2019
19
Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization. 61
29949388 2019
20
Intermediate trophoblastic tumor: the clinical analysis of 62 cases and prognostic factors. 61
30607597 2019
21
[Testicular germ cell tumors: Histopathological and molecular features]. 61
30905378 2019
22
Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide. 61
30815369 2019
23
Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database. 61
30473257 2019
24
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. 61
30407075 2019
25
Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature. 61
31803628 2019
26
Synchronous Choriocarcinoma and Epithelioid Trophoblastic Tumor Concurring at the Cesarean Scar: A Case Report and Review of the Literature. 61
31637071 2019
27
Atypical Placental Site Nodule Arising in a Postcesarean Section Scar: Case Report and Review of the Literature. 61
29140877 2019
28
A typical postcesarean epithelioid trophoblastic lesion with placenta increta: Case report and literature review. 61
30131186 2018
29
A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors. 61
29897391 2018
30
Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor. 61
29757875 2018
31
Comparison of p63 and p40 Immunohistochemical Stains to Distinguish Epithelioid Trophoblastic Tumor From Other Trophoblastic Lesions. 61
28700434 2018
32
Imaging of Metastatic Epithelioid Trophoblastic Tumor With 18F-FDG PET/CT. 61
29659388 2018
33
Laparoscopic diagnosis and treatment of an isolated epithelioid trophoblastic tumor in recto-uterine pouch. 61
29436119 2018
34
Metastatic epithelioid trophoblastic tumor of the lung: A case report. 61
29668580 2018
35
A rare tumor metastasis of bilateral lung: Epithelioid trophoblastic tumor. 61
32082755 2018
36
Reproductive Outcomes After Gestational Trophoblastic Neoplasia. A Comparison Between Single-Agent and Multiagent Chemotherapy: Retrospective Analysis From the MITO-9 Group. 61
29324534 2018
37
Diagnosing and treating rare lesions in a low resource setting: lessons from ahybrid epithelioid trophoblastic tumor and choriocarcinoma. 61
29622835 2017
38
Epithelioid Trophoblastic Tumor Around an Abdominal Cesarean Scar: A Pathologic and Molecular Genetic Analysis. 61
28134666 2017
39
Two cases of epithelioid trophoblastic tumors in postmenopausal women. 61
28590345 2017
40
Sonographic image of cervix epithelioid trophoblastic tumor coexisting with mucinous adenocarcinoma in a postmenopausal woman: A case report. 61
28930821 2017
41
Epithelioid trophoblastic tumor of the uterus: A case report with radiologic-pathologic correlation. 61
28548328 2017
42
Molecular and Immunohistochemical Characteristics of Complete Hydatidiform Moles. 61
28924538 2017
43
[Squamous cell carcinoma in situ of the cervix and placental site nodule: Case report]. 61
28763083 2017
44
Gestational Trophoblastic Disease: Clinical and Imaging Features. 61
28287945 2017
45
PD-L1 Expression in Premalignant and Malignant Trophoblasts From Gestational Trophoblastic Diseases Is Ubiquitous and Independent of Clinical Outcomes. 61
28060141 2017
46
Extrauterine epithelioid trophoblastic tumor in hysterectomized woman. 61
28217684 2017
47
Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities. 61
27789086 2017
48
Clinicopathologic Analysis of Postchemotherapy Gestational Trophoblastic Neoplasia: An Entity Overlapping With Epithelioid Trophoblastic Tumor. 61
26630228 2016
49
MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report. 61
27001388 2016
50
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. 61
27068524 2016

Variations for Epithelioid Trophoblastic Tumor

Expression for Epithelioid Trophoblastic Tumor

Search GEO for disease gene expression data for Epithelioid Trophoblastic Tumor.

Pathways for Epithelioid Trophoblastic Tumor

Pathways related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 MUC1 KRT7 KRT18 ACTC1

GO Terms for Epithelioid Trophoblastic Tumor

Cellular components related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 MUC1 LGALS1 KRT18 INHA CSH2 CSH1
2 vesicle GO:0031982 9.13 MUC1 CSH2 CSH1

Biological processes related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.32 CSH2 CSH1
2 animal organ development GO:0048513 9.26 CSH2 CSH1
3 growth hormone receptor signaling pathway GO:0060396 9.16 CSH2 CSH1
4 positive regulation of growth GO:0045927 8.96 CSH2 CSH1
5 response to nutrient levels GO:0031667 8.8 KRT18 CSH2 CSH1

Molecular functions related to Epithelioid Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 INHA CSH2 CSH1
2 growth hormone receptor binding GO:0005131 8.96 CSH2 CSH1
3 hormone activity GO:0005179 8.92 INHA CSH2 CSH1 CGB3

Sources for Epithelioid Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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