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MCID: EPS001
MIFTS: 31

Epstein-Barr Virus Hepatitis

Categories: Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Epstein-Barr Virus Hepatitis

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MalaCards integrated aliases for Epstein-Barr Virus Hepatitis:

Name: Epstein-Barr Virus Hepatitis 12 15 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050204
UMLS 71 C0554114
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Summaries for Epstein-Barr Virus Hepatitis

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Disease Ontology : 12 A viral hepatitis that results in inflammation, located in liver, has material basis in Human herpesvirus 4 and has symptom headache, has symptom fatigue, has symptom fever, has symptom abdominal pain, has symptom nausea, and has symptom jaundice.

MalaCards based summary : Epstein-Barr Virus Hepatitis is related to psoriatic arthritis and hepatitis, and has symptoms including fatigue, fever and abdominal pain. An important gene associated with Epstein-Barr Virus Hepatitis is AHSG (Alpha 2-HS Glycoprotein), and among its related pathways/superpathways are Allograft rejection and Cellular senescence (KEGG). Affiliated tissues include liver, nk cells and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Epstein-Barr Virus Hepatitis

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Diseases related to Epstein-Barr Virus Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 psoriatic arthritis 29.1 HLA-C HLA-B CD40LG
2 hepatitis 10.6
3 pfeiffer syndrome 10.5
4 pharyngitis 10.3
5 lymphoma 10.2
6 liver disease 10.2
7 burkitt lymphoma 10.1
8 diffuse large b-cell lymphoma 10.1
9 lymphoproliferative syndrome 10.1
10 tonsillitis 10.1
11 disseminated intravascular coagulation 10.1
12 hepatitis a 10.1
13 cholestasis 10.1
14 lymphadenitis 10.1
15 viral hepatitis 10.1
16 autoimmune hepatitis 10.1
17 pustulosis of palm and sole 10.1
18 cervical adenitis 10.1
19 b-cell lymphoma 10.1
20 psoriasis 10.1
21 hepatopulmonary syndrome 10.1
22 encephalitis 10.1
23 47,xyy 10.1
24 post-transplant lymphoproliferative disease 10.1
25 splenomegaly 10.1
26 cytomegalovirus infection 10.1
27 hepatic coma 10.1 GOT1 AHSG
28 idiopathic bronchiectasis 9.9 HLA-C HLA-B
29 colorectal cancer, hereditary nonpolyposis, type 8 9.9 HLA-C HLA-B
30 stevens-johnson syndrome/toxic epidermal necrolysis 9.9 HLA-C HLA-B
31 paraneoplastic pemphigus 9.9 HLA-C HLA-B
32 alveolar echinococcosis 9.9 HLA-C HLA-B
33 psoriasis 1 9.9 HLA-C HLA-B
34 graft-versus-host disease 9.9 HLA-C HLA-B
35 vogt-koyanagi-harada disease 9.9 HLA-C HLA-B
36 spondylitis 9.8 HLA-C HLA-B
37 calciphylaxis 9.8 CD40LG AHSG
38 spondyloarthropathy 9.8 HLA-C HLA-B
39 alopecia areata 9.7 HLA-C HLA-B
40 syphilis 9.7 HLA-C CD40LG
41 selective igg deficiency disease 9.7 HLA-B CD40LG
42 iritis 9.7 HLA-B CD40LG
43 iridocyclitis 9.7 HLA-B CD40LG
44 echinococcosis 9.7 HLA-B CD40LG
45 pure red-cell aplasia 9.7 HLA-B CD40LG
46 cytomegalovirus retinitis 9.7 HLA-B CD40LG
47 histoplasmosis 9.7 HLA-B CD40LG
48 cystic echinococcosis 9.7 HLA-B CD40LG
49 acute disseminated encephalomyelitis 9.7 HLA-B CD40LG
50 panuveitis 9.7 HLA-B CD40LG

Graphical network of the top 20 diseases related to Epstein-Barr Virus Hepatitis:



Diseases related to Epstein-Barr Virus Hepatitis
Sources

Symptoms & Phenotypes for Epstein-Barr Virus Hepatitis

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Symptoms:

12
  • • fatigue
  • • fever
  • • abdominal pain
  • • jaundice
  • • headache
  • • nausea

GenomeRNAi Phenotypes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.28 HLA-B HLA-C
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.28 HLA-B HLA-C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.28 HLA-C
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.28 HLA-B HLA-C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.28 HLA-B HLA-C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.28 HLA-B HLA-C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.28 HLA-C
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.28 HLA-B HLA-C
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.28 HLA-B HLA-C
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.28 HLA-C
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.28 HLA-C
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Drugs & Therapeutics for Epstein-Barr Virus Hepatitis

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Search Clinical Trials , NIH Clinical Center for Epstein-Barr Virus Hepatitis

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Genetic Tests for Epstein-Barr Virus Hepatitis

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Anatomical Context for Epstein-Barr Virus Hepatitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Epstein-Barr Virus Hepatitis:

19
Liver

MalaCards organs/tissues related to Epstein-Barr Virus Hepatitis:

40
Liver, Nk Cells, Lung, Skin, Monocytes, T Cells, B Cells
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Publications for Epstein-Barr Virus Hepatitis

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Articles related to Epstein-Barr Virus Hepatitis:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Reactivation of Epstein-Barr Virus Hepatitis in T/Natural Killer (NK) Cells Mimicking Liver T/NK-Cell Lymphoma. 61
32362967 2020
2
Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial. 61
31958417 2020
3
Acute Epstein-Barr virus hepatitis superimposed on drug induced liver injury causing severe hepatic dysfunction. 61
30482400 2019
4
Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. 61
30315476 2018
5
Epstein-Barr Virus Hepatitis: A Review of Clinicopathologic Features and Differential Diagnosis. 61
30281361 2018
6
Epstein-Barr virus hepatitis can cause transient hepatopulmonary syndrome. 61
29977758 2018
7
Immune Activation, Proinflammatory Cytokines, and Conventional Risks for Cardiovascular Disease in HIV Patients: A Case-Control Study in Bahia, Brazil. 61
29997625 2018
8
Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events. 61
28528469 2017
9
Epstein-Barr virus hepatitis: Importance of PCR assay/serology and significance of γ-GTP. 61
28804977 2017
10
Cancer incidence attributable to lifestyle and environmental factors in Alberta in 2012: summary of results. 61
28687643 2017
11
De Novo Collapsing Glomerulopathy in Renal Allograft in Association with BK Virus Nephropathy in a Child and Stabilization of Renal Function by Elimination of Viremia. 61
28553047 2017
12
Metformin and esophageal cancer risk in Taiwanese patients with type 2 diabetes mellitus. 61
27861146 2017
13
Acute Epstein - Barr virus hepatitis without mononucleosis syndrome: a case report. 61
28702140 2017
14
[Infectious Diseases after Lung Transplantation]. 61
27713192 2016
15
Infectious Complications With the Use of Biologic Response Modifiers in Infants and Children. 61
27432853 2016
16
Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis. 61
26278774 2015
17
[Skin disorder as an indication of viral infection]. 61
26083843 2015
18
Infection and cancer: global distribution and burden of diseases. 61
25512154 2014
19
Viruses and human cancers: a long road of discovery of molecular paradigms. 61
24982317 2014
20
A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. 61
24164103 2014
21
Unusual presentation of Epstein-Barr virus hepatitis treated successfully with valganciclovir. 61
24115018 2014
22
Recognition of human oncogenic viruses by host pattern-recognition receptors. 61
25101093 2014
23
Clinical characteristics of primary Epstein Barr virus hepatitis with elevation of alkaline phosphatase and γ-glutamyltransferase in children. 61
24339294 2014
24
Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature. 61
23897264 2013
25
New proteins for a new perspective on syphilis diagnosis. 61
23100335 2013
26
Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. 61
22554291 2012
27
Involvement of viral factors with head and neck cancers. 61
22078009 2012
28
Viruses and human cancer: from detection to causality. 61
20971551 2011
29
Epstein Barr virus hepatitis. 61
21238898 2011
30
Seroprevalence and Coinfections of Toxoplasma gondii in Childbearing Age Women in Turkey. 61
23113056 2011
31
Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein. 61
20123756 2010
32
The varicella-zoster virus genome. 61
20225013 2010
33
VirusMINT: a viral protein interaction database. 61
18974184 2009
34
The antiviral activities of artemisinin and artesunate. 61
18699744 2008
35
[Effects of viral infection on transplant recipients]. 61
17915112 2007
36
Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients. 61
17721196 2007
37
Absence of chlamydial infection in Japanese patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue. 61
17483059 2007
38
Ganciclovir and the treatment of Epstein-Barr virus hepatitis. 61
16984606 2006
39
Epstein Barr virus hepatitis: case series and review. 61
16711324 2006
40
[Epstein-Barr virus hepatitis associated with icterus--a case report]. 61
17066593 2006
41
[Fatal fulminant Epstein-Barr virus hepatitis]. 61
16556529 2006
42
Primary Epstein-Barr virus hepatitis complicated by ascites with epstein-barr virus reactivation during primary cytomegalovirus infection. 61
12827012 2003
43
Successful treatment with rituximab of lymphoproliferative disorder in a child after cardiac transplantation. 61
12490276 2002
44
Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. 61
11943951 2002
45
[Comparison between cytomegalovirus hepatitis and Epstein-Barr virus hepatitis in healthy adults]. 61
11109765 2000
46
Living donor liver transplantation for fulminant hepatic failure. 61
10919593 2000
47
Virus-associated human tumors: cervical carcinomas and papilloma viruses. 61
10702642 2000
48
An infectious mononucleosis-like syndrome induced by minocycline: a third pattern of adverse drug reaction. 61
10467499 1999
49
Brief report: Pediatric Burkitt lymphoma with concurrent chronic Epstein-Barr virus hepatitis. 61
10398194 1999
50
Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma. 61
9329592 1997
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Variations for Epstein-Barr Virus Hepatitis

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Expression for Epstein-Barr Virus Hepatitis

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Search GEO for disease gene expression data for Epstein-Barr Virus Hepatitis.
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Pathways for Epstein-Barr Virus Hepatitis

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Pathways related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 36
Show member pathways
 12.17 HLA-C HLA-B CD40LG
2
Cellular senescence (KEGG) 36
11.56 HLA-C HLA-B
3
Phagosome 36
11.5 HLA-C HLA-B
4
Cell adhesion molecules (CAMs) 36
11.3 HLA-C HLA-B CD40LG
5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
10.93 HLA-C HLA-B CD40LG
6
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 65
10.55 HLA-C HLA-B
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GO Terms for Epstein-Barr Virus Hepatitis

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Cellular components related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 HLA-C HLA-B GOT1 AHSG
2 cell surface GO:0009986 9.54 HLA-C HLA-B CD40LG
3 secretory granule membrane GO:0030667 9.4 HLA-C HLA-B
4 recycling endosome membrane GO:0055038 9.32 HLA-C HLA-B
5 phagocytic vesicle membrane GO:0030670 9.26 HLA-C HLA-B
6 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-C HLA-B
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-C HLA-B
8 MHC class I protein complex GO:0042612 8.62 HLA-C HLA-B

Biological processes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.61 HLA-C HLA-B CD40LG
2 neutrophil degranulation GO:0043312 9.54 HLA-C HLA-B AHSG
3 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.48 HLA-C HLA-B
4 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-C HLA-B
5 type I interferon signaling pathway GO:0060337 9.4 HLA-C HLA-B
6 regulation of immune response GO:0050776 9.33 HLA-C HLA-B CD40LG
7 antigen processing and presentation GO:0019882 9.32 HLA-C HLA-B
8 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.26 HLA-C HLA-B
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.96 HLA-C HLA-B
10 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 8.62 HLA-C HLA-B

Molecular functions related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-C HLA-B
2 TAP binding GO:0046977 8.62 HLA-C HLA-B
Sources

Sources for Epstein-Barr Virus Hepatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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