MCID: EPS001
MIFTS: 33

Epstein-Barr Virus Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Epstein-Barr Virus Hepatitis

MalaCards integrated aliases for Epstein-Barr Virus Hepatitis:

Name: Epstein-Barr Virus Hepatitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050204
UMLS 74 C0554114

Summaries for Epstein-Barr Virus Hepatitis

Disease Ontology : 12 A viral hepatitis that results in inflammation, located in liver, has material basis in Human herpesvirus 4 and has symptom headache, has symptom fatigue, has symptom fever, has symptom abdominal pain, has symptom nausea, and has symptom jaundice.

MalaCards based summary : Epstein-Barr Virus Hepatitis is related to hepatitis and hepatitis a, and has symptoms including fever, fatigue and abdominal pain. An important gene associated with Epstein-Barr Virus Hepatitis is AHSG (Alpha 2-HS Glycoprotein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Nicotinamide and Milk thistle have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and b cells.

Related Diseases for Epstein-Barr Virus Hepatitis

Diseases related to Epstein-Barr Virus Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 hepatitis 30.9 F2 GPT
2 hepatitis a 29.4 ALB F2 GPT
3 lymphoma 10.2
4 testicular yolk sac tumor 10.1 AHSG ALB
5 burkitt lymphoma 10.0
6 diffuse large b-cell lymphoma 10.0
7 hepatitis c 10.0
8 psoriasis 10.0
9 hepatopulmonary syndrome 10.0
10 cytomegalovirus infection 10.0
11 antipyrine metabolism 10.0 ALB F2
12 non-a-e hepatitis 10.0 ALB F2
13 fournier gangrene 10.0 ALB F2
14 abdominal tuberculosis 10.0 ALB F2
15 eccrine adenocarcinoma 10.0 AHSG F2
16 splenic disease 10.0 ALB F2
17 esophageal varix 10.0 ALB F2
18 ascending cholangitis 10.0 ALB F2
19 hypersplenism 10.0 ALB F2
20 compartment syndrome 10.0 ALB F2
21 hepatorenal syndrome 10.0 ALB F2
22 autoimmune disease of urogenital tract 10.0 ALB F2
23 hepatic vascular disease 10.0 ALB F2
24 pulmonary artery disease 10.0 ALB F2
25 dysfibrinogenemia 10.0 ALB F2
26 vein disease 10.0 ALB F2
27 intermittent claudication 10.0 ALB F2
28 typhoid fever 10.0 ALB F2
29 dengue hemorrhagic fever 10.0 ALB F2
30 biliary tract disease 10.0 ALB F2
31 uremia 10.0 AHSG ALB
32 homocysteinemia 10.0 ALB F2
33 endocarditis 10.0 ALB F2
34 pulmonary embolism 10.0 ALB F2
35 peripheral vascular disease 10.0 ALB F2
36 schistosomiasis 9.9 ALB F2
37 fascioliasis 9.9 ALB GPT
38 peritonitis 9.9 ALB F2
39 protein-energy malnutrition 9.9 ALB GPT
40 eclampsia 9.9 ALB F2
41 hepatoportal sclerosis 9.9 F2 GPT
42 cholelithiasis 9.9 ALB GPT
43 hepatitis d 9.9 F2 GPT
44 nonalcoholic steatohepatitis 9.9 F2 GPT
45 biliary atresia 9.8 ALB GPT
46 gastrointestinal system cancer 9.8 ALB F2
47 cholangitis, primary sclerosing 9.8 ALB GPT
48 endocrine gland cancer 9.8 ALB F2
49 alcoholic liver cirrhosis 9.8 AHSG ALB F2
50 gastrointestinal system disease 9.7 ALB F2

Graphical network of the top 20 diseases related to Epstein-Barr Virus Hepatitis:



Diseases related to Epstein-Barr Virus Hepatitis

Symptoms & Phenotypes for Epstein-Barr Virus Hepatitis

Symptoms:

12
  • fever
  • fatigue
  • abdominal pain
  • jaundice
  • headache
  • nausea

Drugs & Therapeutics for Epstein-Barr Virus Hepatitis

Drugs for Epstein-Barr Virus Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 2, Phase 3,Phase 3 98-92-0 936
2
Milk thistle Approved, Experimental, Investigational Phase 2, Phase 3 65666-07-1
3
Niacin Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 59-67-6 938
4
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 70-16-6, 59-43-8 1130
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
6
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
7 Nicotinic Acids Phase 2, Phase 3
8 Antioxidants Phase 2, Phase 3
9 Trace Elements Phase 2, Phase 3
10 Vitamins Phase 2, Phase 3
11 Vitamin B Complex Phase 2, Phase 3
12 Vitamin B9 Phase 2, Phase 3
13 Vitamin B2 Phase 2, Phase 3
14 Protective Agents Phase 2, Phase 3
15 silymarin Phase 2, Phase 3
16 Vitamin B3 Phase 2, Phase 3
17 Nutrients Phase 2, Phase 3
18 Folate Phase 2, Phase 3
19 Thiamin Phase 2, Phase 3
20 Micronutrients Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis Terminated NCT00755950 Phase 2, Phase 3

Search NIH Clinical Center for Epstein-Barr Virus Hepatitis

Genetic Tests for Epstein-Barr Virus Hepatitis

Anatomical Context for Epstein-Barr Virus Hepatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Epstein-Barr Virus Hepatitis:

20
Liver

MalaCards organs/tissues related to Epstein-Barr Virus Hepatitis:

42
Liver, B Cells

Publications for Epstein-Barr Virus Hepatitis

Articles related to Epstein-Barr Virus Hepatitis:

(show all 21)
# Title Authors Year
1
Acute Epstein-Barr virus hepatitis superimposed on drug induced liver injury causing severe hepatic dysfunction. ( 30482400 )
2019
2
Epstein-Barr virus hepatitis can cause transient hepatopulmonary syndrome. ( 29977758 )
2018
3
Epstein-Barr Virus Hepatitis: A Review of Clinicopathologic Features and Differential Diagnosis. ( 30281361 )
2018
4
Acute Epstein - Barr virus hepatitis without mononucleosis syndrome: a case report. ( 28702140 )
2017
5
Epstein-Barr virus hepatitis: Importance of PCR assay/serology and significance of γ-GTP. ( 28804977 )
2017
6
Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis. ( 26278774 )
2015
7
A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. ( 24164103 )
2014
8
Unusual presentation of Epstein-Barr virus hepatitis treated successfully with valganciclovir. ( 24115018 )
2014
9
Clinical characteristics of primary Epstein Barr virus hepatitis with elevation of alkaline phosphatase and γ-glutamyltransferase in children. ( 24339294 )
2014
10
Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. ( 22554291 )
2012
11
Epstein Barr virus hepatitis. ( 21238898 )
2011
12
Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients. ( 17721196 )
2007
13
Epstein Barr virus hepatitis: case series and review. ( 16711324 )
2006
14
Ganciclovir and the treatment of Epstein-Barr virus hepatitis. ( 16984606 )
2006
15
[Epstein-Barr virus hepatitis associated with icterus--a case report]. ( 17066593 )
2006
16
Primary Epstein-Barr virus hepatitis complicated by ascites with epstein-barr virus reactivation during primary cytomegalovirus infection. ( 12827012 )
2003
17
Brief report: Pediatric Burkitt lymphoma with concurrent chronic Epstein-Barr virus hepatitis. ( 10398194 )
1999
18
Comparison between sporadic cytomegalovirus hepatitis and Epstein-Barr virus hepatitis in previously healthy adults. ( 9138274 )
1997
19
Epstein-Barr virus hepatitis after liver transplantation. ( 8017367 )
1994
20
Near-fatal coagulopathy associated with Epstein-Barr virus hepatitis. ( 3012886 )
1986
21
The spectrum of Epstein-Barr virus hepatitis in children. ( 3024140 )
1986

Variations for Epstein-Barr Virus Hepatitis

Expression for Epstein-Barr Virus Hepatitis

Search GEO for disease gene expression data for Epstein-Barr Virus Hepatitis.

Pathways for Epstein-Barr Virus Hepatitis

Pathways related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 AHSG ALB F2
2
Show member pathways
11.49 ALB F2
3 10.27 ALB F2

GO Terms for Epstein-Barr Virus Hepatitis

Cellular components related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 AHSG ALB F2 GPT
2 extracellular space GO:0005615 9.46 AHSG ALB F2 GPT
3 platelet alpha granule lumen GO:0031093 9.26 AHSG ALB
4 endoplasmic reticulum lumen GO:0005788 9.13 AHSG ALB F2
5 blood microparticle GO:0072562 8.8 AHSG ALB F2

Biological processes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.16 AHSG ALB
2 acute-phase response GO:0006953 8.96 AHSG F2
3 cellular protein metabolic process GO:0044267 8.8 AHSG ALB F2

Molecular functions related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Epstein-Barr Virus Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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