MCID: EPS001
MIFTS: 30

Epstein-Barr Virus Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Epstein-Barr Virus Hepatitis

MalaCards integrated aliases for Epstein-Barr Virus Hepatitis:

Name: Epstein-Barr Virus Hepatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050204
UMLS 73 C0554114

Summaries for Epstein-Barr Virus Hepatitis

Disease Ontology : 12 A viral hepatitis that results in inflammation, located in liver, has material basis in Human herpesvirus 4 and has symptom headache, has symptom fatigue, has symptom fever, has symptom abdominal pain, has symptom nausea, and has symptom jaundice.

MalaCards based summary : Epstein-Barr Virus Hepatitis is related to hepatitis a and hepatitis, and has symptoms including fever, fatigue and abdominal pain. An important gene associated with Epstein-Barr Virus Hepatitis is AHSG (Alpha 2-HS Glycoprotein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Nicotinamide and Milk thistle have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and kidney.

Related Diseases for Epstein-Barr Virus Hepatitis

Diseases related to Epstein-Barr Virus Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 hepatitis a 29.9 ALB F2
2 hepatitis 10.7
3 yellow nail syndrome 10.0 ALB TF
4 marasmus 10.0 ALB TF
5 pure red-cell aplasia 10.0 ALB TF
6 ariboflavinosis 10.0 ALB TF
7 burkitt lymphoma 10.0
8 b-cell lymphomas 10.0
9 diffuse large b-cell lymphoma 10.0
10 lymphoma 10.0
11 hepatitis c 10.0
12 psoriasis 10.0
13 hepatopulmonary syndrome 10.0
14 cytomegalovirus infection 10.0
15 lipoid nephrosis 10.0 ALB TF
16 dysentery 10.0 ALB TF
17 protein-energy malnutrition 10.0 ALB TF
18 nutritional deficiency disease 10.0 ALB TF
19 end stage renal failure 10.0 ALB TF
20 antipyrine metabolism 10.0 ALB F2
21 non-a-e hepatitis 10.0 ALB F2
22 fournier gangrene 10.0 ALB F2
23 abdominal tuberculosis 10.0 ALB F2
24 hepatic tuberculosis 10.0 ALB F2
25 eccrine adenocarcinoma 10.0 AHSG F2
26 hepatic coma 10.0 ALB F2
27 infantile liver failure syndrome 1 10.0 ALB F2
28 splenic disease 10.0 ALB F2
29 esophageal varix 10.0 ALB F2
30 ascending cholangitis 10.0 ALB F2
31 cholangitis 10.0 ALB F2
32 trypanosomiasis 10.0 ALB TF
33 hypersplenism 10.0 ALB F2
34 compartment syndrome 10.0 ALB F2
35 hemorrhagic fever 10.0 ALB F2
36 hepatorenal syndrome 10.0 ALB F2
37 choledocholithiasis 10.0 ALB F2
38 autoimmune disease of urogenital tract 10.0 ALB F2
39 hepatic vascular disease 10.0 ALB F2
40 pulmonary artery disease 10.0 ALB F2
41 dysfibrinogenemia 10.0 ALB F2
42 membranous nephropathy 9.9 ALB TF
43 acute liver failure 9.9 ALB F2
44 hepatitis e 9.9 ALB F2
45 vein disease 9.9 ALB F2
46 intermittent claudication 9.9 ALB F2
47 bile duct disease 9.9 ALB F2
48 urinary system disease 9.9 ALB TF
49 typhoid fever 9.9 ALB F2
50 cholecystitis 9.9 ALB F2

Graphical network of the top 20 diseases related to Epstein-Barr Virus Hepatitis:



Diseases related to Epstein-Barr Virus Hepatitis

Symptoms & Phenotypes for Epstein-Barr Virus Hepatitis

Symptoms:

12
  • fever
  • fatigue
  • abdominal pain
  • jaundice
  • headache
  • nausea

Drugs & Therapeutics for Epstein-Barr Virus Hepatitis

Drugs for Epstein-Barr Virus Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 2, Phase 3,Phase 3 98-92-0 936
2
Milk thistle Approved, Experimental, Investigational Phase 2, Phase 3 65666-07-1
3
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-43-8, 70-16-6 1130
4
Niacin Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 59-67-6 938
5
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
7 Antioxidants Phase 2, Phase 3
8 Vitamin B Complex Phase 2, Phase 3
9 Vitamin B3 Phase 2, Phase 3
10 Vitamins Phase 2, Phase 3
11 Vitamin B9 Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3
13 silymarin Phase 2, Phase 3
14 Folate Phase 2, Phase 3
15 Thiamin Phase 2, Phase 3
16 Vitamin B2 Phase 2, Phase 3
17 Trace Elements Phase 2, Phase 3
18 Nicotinic Acids Phase 2, Phase 3
19 Micronutrients Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis Terminated NCT00755950 Phase 2, Phase 3

Search NIH Clinical Center for Epstein-Barr Virus Hepatitis

Genetic Tests for Epstein-Barr Virus Hepatitis

Anatomical Context for Epstein-Barr Virus Hepatitis

MalaCards organs/tissues related to Epstein-Barr Virus Hepatitis:

41
Liver, B Cells, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Epstein-Barr Virus Hepatitis:

19
Liver

Publications for Epstein-Barr Virus Hepatitis

Articles related to Epstein-Barr Virus Hepatitis:

(show all 21)
# Title Authors Year
1
Epstein-Barr virus hepatitis can cause transient hepatopulmonary syndrome. ( 29977758 )
2018
2
Epstein-Barr Virus Hepatitis: A Review of Clinicopathologic Features and Differential Diagnosis. ( 30281361 )
2018
3
Acute Epstein-Barr virus hepatitis superimposed on drug induced liver injury causing severe hepatic dysfunction. ( 30482400 )
2018
4
Acute Epstein - Barr virus hepatitis without mononucleosis syndrome: a case report. ( 28702140 )
2017
5
Epstein-Barr virus hepatitis: Importance of PCR assay/serology and significance of I^-GTP. ( 28804977 )
2017
6
Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis. ( 26278774 )
2015
7
Unusual presentation of Epstein-Barr virus hepatitis treated successfully with valganciclovir. ( 24115018 )
2014
8
Clinical Characteristics of Primary Epstein Barr Virus Hepatitis with Elevation of Alkaline Phosphatase and I^-Glutamyltransferase in Children. ( 24339294 )
2014
9
A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. ( 24164103 )
2013
10
Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. ( 22554291 )
2012
11
Epstein Barr virus hepatitis. ( 21238898 )
2011
12
Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients. ( 17721196 )
2007
13
Ganciclovir and the treatment of Epstein-Barr virus hepatitis. ( 16984606 )
2006
14
[Epstein-Barr virus hepatitis associated with icterus--a case report]. ( 17066593 )
2006
15
Epstein Barr virus hepatitis: case series and review. ( 16711324 )
2006
16
Primary Epstein-Barr virus hepatitis complicated by ascites with epstein-barr virus reactivation during primary cytomegalovirus infection. ( 12827012 )
2003
17
Brief report: Pediatric Burkitt lymphoma with concurrent chronic Epstein-Barr virus hepatitis. ( 10398194 )
1999
18
Comparison between sporadic cytomegalovirus hepatitis and Epstein-Barr virus hepatitis in previously healthy adults. ( 9138274 )
1997
19
Epstein-Barr virus hepatitis after liver transplantation. ( 8017367 )
1994
20
Near-fatal coagulopathy associated with Epstein-Barr virus hepatitis. ( 3012886 )
1986
21
The spectrum of Epstein-Barr virus hepatitis in children. ( 3024140 )
1986

Variations for Epstein-Barr Virus Hepatitis

Expression for Epstein-Barr Virus Hepatitis

Search GEO for disease gene expression data for Epstein-Barr Virus Hepatitis.

Pathways for Epstein-Barr Virus Hepatitis

Pathways related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 AHSG ALB F2 TF
2
Show member pathways
11.49 ALB F2
3 10.6 ALB F2

GO Terms for Epstein-Barr Virus Hepatitis

Cellular components related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.67 AHSG ALB F2 TF
2 extracellular exosome GO:0070062 9.62 AHSG ALB F2 TF
3 extracellular space GO:0005615 9.46 AHSG ALB F2 TF
4 secretory granule lumen GO:0034774 9.4 AHSG TF
5 platelet alpha granule lumen GO:0031093 9.26 AHSG ALB
6 endoplasmic reticulum lumen GO:0005788 9.26 AHSG ALB F2 TF
7 blood microparticle GO:0072562 8.92 AHSG ALB F2 TF

Biological processes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.33 AHSG ALB TF
2 retina homeostasis GO:0001895 9.32 ALB TF
3 acute-phase response GO:0006953 9.26 AHSG F2
4 platelet degranulation GO:0002576 9.13 AHSG ALB TF
5 cellular protein metabolic process GO:0044267 8.92 AHSG ALB F2 TF

Sources for Epstein-Barr Virus Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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