MCID: EPS001
MIFTS: 30

Epstein-Barr Virus Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Epstein-Barr Virus Hepatitis

MalaCards integrated aliases for Epstein-Barr Virus Hepatitis:

Name: Epstein-Barr Virus Hepatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050204
UMLS 73 C0554114

Summaries for Epstein-Barr Virus Hepatitis

Disease Ontology : 12 A viral hepatitis that results in inflammation, located in liver, has material basis in Human herpesvirus 4 and has symptom headache, has symptom fatigue, has symptom fever, has symptom abdominal pain, has symptom nausea, and has symptom jaundice.

MalaCards based summary : Epstein-Barr Virus Hepatitis is related to hepatitis and lymphoma, and has symptoms including headache, fatigue and fever. An important gene associated with Epstein-Barr Virus Hepatitis is AHSG (Alpha 2-HS Glycoprotein), and among its related pathways/superpathways is Response to elevated platelet cytosolic Ca2+. The drugs Nicotinamide and Niacin have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and b cells.

Related Diseases for Epstein-Barr Virus Hepatitis

Diseases related to Epstein-Barr Virus Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 hepatitis 10.6
2 lymphoma 10.1
3 burkitt lymphoma 9.9
4 b-cell lymphomas 9.9
5 diffuse large b-cell lymphoma 9.9
6 hepatitis c 9.9
7 psoriasis 9.9
8 hepatopulmonary syndrome 9.9
9 cytomegalovirus infection 9.9
10 kwashiorkor 9.6 F2 TF
11 orbital cyst 9.6 F2 TF
12 analbuminemia 9.6 F2 TF
13 nutritional deficiency disease 9.6 F2 TF
14 adult respiratory distress syndrome 9.5 F2 TF
15 wilson disease 9.5 F2 TF
16 testicular yolk sac tumor 9.5 AHSG TF
17 immune system disease 9.3 F2 TF
18 uremia 9.3 AHSG TF
19 liver cirrhosis 9.2 F2 TF
20 liver disease 9.0 F2 TF
21 alcoholic liver cirrhosis 8.9 AHSG F2 TF

Graphical network of the top 20 diseases related to Epstein-Barr Virus Hepatitis:



Diseases related to Epstein-Barr Virus Hepatitis

Symptoms & Phenotypes for Epstein-Barr Virus Hepatitis

Symptoms:

12
  • headache
  • fatigue
  • fever
  • abdominal pain
  • nausea
  • jaundice

Drugs & Therapeutics for Epstein-Barr Virus Hepatitis

Drugs for Epstein-Barr Virus Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 98-92-0 936
2
Niacin Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 59-67-6 938
3
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
4
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-43-8, 70-16-6 1130
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
6 Micronutrients Phase 2, Phase 3
7 Nicotinic Acids Phase 2, Phase 3
8 Trace Elements Phase 2, Phase 3
9 Vitamin B Complex Phase 2, Phase 3
10 Vitamins Phase 2, Phase 3
11 Antioxidants Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3
13 silymarin Nutraceutical Phase 2, Phase 3
14 Folate Nutraceutical Phase 2, Phase 3
15 Vitamin B3 Nutraceutical Phase 2, Phase 3
16 Milk Thistle Nutraceutical Phase 2, Phase 3
17 Thiamin Nutraceutical Phase 2, Phase 3
18 Vitamin B2 Nutraceutical Phase 2, Phase 3
19 Vitamin B9 Nutraceutical Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis Terminated NCT00755950 Phase 2, Phase 3

Search NIH Clinical Center for Epstein-Barr Virus Hepatitis

Genetic Tests for Epstein-Barr Virus Hepatitis

Anatomical Context for Epstein-Barr Virus Hepatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Epstein-Barr Virus Hepatitis:

19
Liver

MalaCards organs/tissues related to Epstein-Barr Virus Hepatitis:

41
Liver, B Cells

Publications for Epstein-Barr Virus Hepatitis

Articles related to Epstein-Barr Virus Hepatitis:

(show all 19)
# Title Authors Year
1
Epstein-Barr virus hepatitis can cause transient hepatopulmonary syndrome. ( 29977758 )
2018
2
Acute Epstein - Barr virus hepatitis without mononucleosis syndrome: a case report. ( 28702140 )
2017
3
Epstein-Barr virus hepatitis: Importance of PCR assay/serology and significance of I^-GTP. ( 28804977 )
2017
4
Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis. ( 26278774 )
2015
5
Unusual presentation of Epstein-Barr virus hepatitis treated successfully with valganciclovir. ( 24115018 )
2014
6
Clinical Characteristics of Primary Epstein Barr Virus Hepatitis with Elevation of Alkaline Phosphatase and I^-Glutamyltransferase in Children. ( 24339294 )
2014
7
A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. ( 24164103 )
2013
8
Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. ( 22554291 )
2012
9
Epstein Barr virus hepatitis. ( 21238898 )
2011
10
Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients. ( 17721196 )
2007
11
Ganciclovir and the treatment of Epstein-Barr virus hepatitis. ( 16984606 )
2006
12
[Epstein-Barr virus hepatitis associated with icterus--a case report]. ( 17066593 )
2006
13
Epstein Barr virus hepatitis: case series and review. ( 16711324 )
2006
14
Primary Epstein-Barr virus hepatitis complicated by ascites with epstein-barr virus reactivation during primary cytomegalovirus infection. ( 12827012 )
2003
15
Brief report: Pediatric Burkitt lymphoma with concurrent chronic Epstein-Barr virus hepatitis. ( 10398194 )
1999
16
Comparison between sporadic cytomegalovirus hepatitis and Epstein-Barr virus hepatitis in previously healthy adults. ( 9138274 )
1997
17
Epstein-Barr virus hepatitis after liver transplantation. ( 8017367 )
1994
18
Near-fatal coagulopathy associated with Epstein-Barr virus hepatitis. ( 3012886 )
1986
19
The spectrum of Epstein-Barr virus hepatitis in children. ( 3024140 )
1986

Variations for Epstein-Barr Virus Hepatitis

Expression for Epstein-Barr Virus Hepatitis

Search GEO for disease gene expression data for Epstein-Barr Virus Hepatitis.

Pathways for Epstein-Barr Virus Hepatitis

Pathways related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 AHSG F2 TF

GO Terms for Epstein-Barr Virus Hepatitis

Cellular components related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.54 AHSG F2 TF
2 extracellular region GO:0005576 9.5 AHSG F2 TF
3 extracellular space GO:0005615 9.43 AHSG F2 TF
4 secretory granule lumen GO:0034774 9.16 AHSG TF
5 endoplasmic reticulum lumen GO:0005788 9.13 AHSG F2 TF
6 blood microparticle GO:0072562 8.8 AHSG F2 TF

Biological processes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.26 AHSG TF
2 platelet degranulation GO:0002576 9.16 AHSG TF
3 acute-phase response GO:0006953 8.96 AHSG F2
4 cellular protein metabolic process GO:0044267 8.8 AHSG F2 TF

Sources for Epstein-Barr Virus Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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