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MCID: EPS001
MIFTS: 32

Epstein-Barr Virus Hepatitis

Categories: Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Epstein-Barr Virus Hepatitis

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MalaCards integrated aliases for Epstein-Barr Virus Hepatitis:

Name: Epstein-Barr Virus Hepatitis 12 15 70

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050204
UMLS 70 C0554114
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Summaries for Epstein-Barr Virus Hepatitis

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Disease Ontology : 12 A viral hepatitis that results in inflammation, located in liver, has material basis in Human herpesvirus 4 and has symptom headache, has symptom fatigue, has symptom fever, has symptom abdominal pain, has symptom nausea, and has symptom jaundice.

MalaCards based summary : Epstein-Barr Virus Hepatitis is related to human cytomegalovirus infection and psoriatic arthritis, and has symptoms including fatigue, fever and jaundice. An important gene associated with Epstein-Barr Virus Hepatitis is AHSG (Alpha 2-HS Glycoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Actin Nucleation by ARP-WASP Complex. Affiliated tissues include liver, nk cells and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Epstein-Barr Virus Hepatitis

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Diseases related to Epstein-Barr Virus Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 human cytomegalovirus infection 30.1 HLA-C HLA-A
2 psoriatic arthritis 29.8 HLA-C HLA-B HLA-A
3 psoriasis 29.7 HLA-C HLA-B HLA-A
4 hepatitis 10.6
5 pfeiffer syndrome 10.5
6 lymphoma 10.3
7 hepatitis a 10.3
8 autoimmune hepatitis 10.3
9 viral hepatitis 10.2
10 pharyngitis 10.2
11 burkitt lymphoma 10.1
12 diffuse large b-cell lymphoma 10.1
13 lymphoproliferative syndrome 10.1
14 non-alcoholic fatty liver disease 10.1
15 tonsillitis 10.1
16 disseminated intravascular coagulation 10.1
17 cholestasis 10.1
18 lymphadenitis 10.1
19 hepatitis c 10.1
20 liver disease 10.1
21 pustulosis of palm and sole 10.1
22 cervical adenitis 10.1
23 b-cell lymphoma 10.1
24 herpes simplex 10.1
25 chickenpox 10.1
26 hepatopulmonary syndrome 10.1
27 post-transplant lymphoproliferative disease 10.1
28 splenomegaly 10.1
29 postherpetic neuralgia 10.0 HLA-B HLA-A
30 frontal fibrosing alopecia 10.0 HLA-B HLA-A
31 psoriasis 1 10.0 HLA-C HLA-B
32 htlv-1 associated myelopathy/tropical spastic paraparesis 10.0 HLA-B HLA-A
33 tropical spastic paraparesis 10.0 HLA-B HLA-A
34 spastic paraparesis 10.0 HLA-B HLA-A
35 nontuberculous mycobacterial lung disease 10.0 HLA-B HLA-A
36 selective igg deficiency disease 10.0 HLA-B HLA-A
37 birdshot chorioretinopathy 10.0 HLA-C HLA-A
38 mental retardation, autosomal dominant 40 10.0 HLA-B HLA-A
39 pars planitis 10.0 HLA-B HLA-A
40 chronic pyelonephritis 10.0 HLA-B HLA-A
41 cytomegalovirus retinitis 10.0 HLA-B HLA-A
42 histoplasmosis 10.0 HLA-B HLA-A
43 pure red-cell aplasia 10.0 HLA-B HLA-A
44 spondylitis 9.9 HLA-C HLA-B
45 aphthous stomatitis 9.9 HLA-B HLA-A
46 herpes zoster 9.9 HLA-B HLA-A
47 dengue hemorrhagic fever 9.9 HLA-B HLA-A
48 severe acute respiratory syndrome 9.9 HLA-C HLA-A
49 takayasu arteritis 9.9 HLA-B HLA-A
50 leprosy 3 9.9 HLA-B HLA-A

Graphical network of the top 20 diseases related to Epstein-Barr Virus Hepatitis:



Diseases related to Epstein-Barr Virus Hepatitis
Sources

Symptoms & Phenotypes for Epstein-Barr Virus Hepatitis

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Symptoms:

12
  • • fatigue
  • • fever
  • • jaundice
  • • abdominal pain
  • • headache
  • • nausea

GenomeRNAi Phenotypes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.9 HLA-A HLA-B HLA-C
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.9 HLA-A HLA-B HLA-C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.9 HLA-C
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.9 HLA-A HLA-B HLA-C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.9 HLA-A HLA-B HLA-C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.9 HLA-A HLA-B HLA-C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.9 HLA-C
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.9 HLA-A HLA-B HLA-C
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.9 HLA-A HLA-B HLA-C
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.9 HLA-C
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.9 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.66 HLA-A HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.66 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.66 HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.66 HLA-A HLA-B HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.66 HLA-C
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Drugs & Therapeutics for Epstein-Barr Virus Hepatitis

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Search Clinical Trials , NIH Clinical Center for Epstein-Barr Virus Hepatitis

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Genetic Tests for Epstein-Barr Virus Hepatitis

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Anatomical Context for Epstein-Barr Virus Hepatitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Epstein-Barr Virus Hepatitis:

19
Liver

MalaCards organs/tissues related to Epstein-Barr Virus Hepatitis:

40
Liver, Nk Cells, Lung, Skin
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Publications for Epstein-Barr Virus Hepatitis

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Articles related to Epstein-Barr Virus Hepatitis:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: Recent findings from NHANES 1999-2016. 61
33578314 2021
2
From infection to cancer: how DNA tumour viruses alter host cell central carbon and lipid metabolism. 61
33653084 2021
3
A case series analysis of serious exacerbations of viral hepatitis and non-viral hepatic injuries in tocilizumab-treated patients. 61
33320444 2021
4
Diagnostic dilemmas in Epstein-Barr virus hepatitis mimicking autoimmune hepatitis: A case report. 61
32754529 2020
5
Reactivation of Epstein-Barr Virus Hepatitis in T/Natural Killer (NK) Cells Mimicking Liver T/NK-Cell Lymphoma. 61
32362967 2020
6
Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial. 61
31958417 2020
7
[Autoimmune hepatitis following acute severe Epstein-Barr virus hepatitis]. 61
33244340 2020
8
Acute Epstein-Barr virus hepatitis superimposed on drug induced liver injury causing severe hepatic dysfunction. 61
30482400 2019
9
Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. 61
30315476 2018
10
Epstein-Barr Virus Hepatitis: A Review of Clinicopathologic Features and Differential Diagnosis. 61
30281361 2018
11
Epstein-Barr virus hepatitis can cause transient hepatopulmonary syndrome. 61
29977758 2018
12
Immune Activation, Proinflammatory Cytokines, and Conventional Risks for Cardiovascular Disease in HIV Patients: A Case-Control Study in Bahia, Brazil. 61
29997625 2018
13
Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events. 61
28528469 2017
14
Epstein-Barr virus hepatitis: Importance of PCR assay/serology and significance of γ-GTP. 61
28804977 2017
15
Cancer incidence attributable to lifestyle and environmental factors in Alberta in 2012: summary of results. 61
28687643 2017
16
De Novo Collapsing Glomerulopathy in Renal Allograft in Association with BK Virus Nephropathy in a Child and Stabilization of Renal Function by Elimination of Viremia. 61
28553047 2017
17
Metformin and esophageal cancer risk in Taiwanese patients with type 2 diabetes mellitus. 61
27861146 2017
18
Acute Epstein - Barr virus hepatitis without mononucleosis syndrome: a case report. 61
28702140 2017
19
[Infectious Diseases after Lung Transplantation]. 61
27713192 2016
20
Infectious Complications With the Use of Biologic Response Modifiers in Infants and Children. 61
27432853 2016
21
Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis. 61
26278774 2015
22
[Skin disorder as an indication of viral infection]. 61
26083843 2015
23
Infection and cancer: global distribution and burden of diseases. 61
25512154 2014
24
Viruses and human cancers: a long road of discovery of molecular paradigms. 61
24982317 2014
25
A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. 61
24164103 2014
26
Unusual presentation of Epstein-Barr virus hepatitis treated successfully with valganciclovir. 61
24115018 2014
27
Recognition of human oncogenic viruses by host pattern-recognition receptors. 61
25101093 2014
28
Clinical characteristics of primary Epstein Barr virus hepatitis with elevation of alkaline phosphatase and γ-glutamyltransferase in children. 61
24339294 2014
29
Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature. 61
23897264 2013
30
New proteins for a new perspective on syphilis diagnosis. 61
23100335 2013
31
Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. 61
22554291 2012
32
Involvement of viral factors with head and neck cancers. 61
22078009 2012
33
Viruses and human cancer: from detection to causality. 61
20971551 2011
34
Epstein Barr virus hepatitis. 61
21238898 2011
35
Seroprevalence and Coinfections of Toxoplasma gondii in Childbearing Age Women in Turkey. 61
23113056 2011
36
Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein. 61
20123756 2010
37
The varicella-zoster virus genome. 61
20225013 2010
38
VirusMINT: a viral protein interaction database. 61
18974184 2009
39
The antiviral activities of artemisinin and artesunate. 61
18699744 2008
40
[Effects of viral infection on transplant recipients]. 61
17915112 2007
41
Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients. 61
17721196 2007
42
Absence of chlamydial infection in Japanese patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue. 61
17483059 2007
43
Ganciclovir and the treatment of Epstein-Barr virus hepatitis. 61
16984606 2006
44
Epstein Barr virus hepatitis: case series and review. 61
16711324 2006
45
[Fatal fulminant Epstein-Barr virus hepatitis]. 61
16556529 2006
46
[Epstein-Barr virus hepatitis associated with icterus--a case report]. 61
17066593 2006
47
Primary Epstein-Barr virus hepatitis complicated by ascites with epstein-barr virus reactivation during primary cytomegalovirus infection. 61
12827012 2003
48
Successful treatment with rituximab of lymphoproliferative disorder in a child after cardiac transplantation. 61
12490276 2002
49
Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. 61
11943951 2002
50
[Comparison between cytomegalovirus hepatitis and Epstein-Barr virus hepatitis in healthy adults]. 61
11109765 2000
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Variations for Epstein-Barr Virus Hepatitis

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Expression for Epstein-Barr Virus Hepatitis

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Search GEO for disease gene expression data for Epstein-Barr Virus Hepatitis.
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Pathways for Epstein-Barr Virus Hepatitis

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Pathways related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.59 HLA-C HLA-B HLA-A
2
Actin Nucleation by ARP-WASP Complex 63
Show member pathways
 12.57 HLA-C HLA-B HLA-A
3
Human cytomegalovirus infection 36
Show member pathways
 12.54 HLA-C HLA-B HLA-A
4
Allograft rejection 36 1
Show member pathways
 12.45 HLA-C HLA-B HLA-A
5
Measles 36
Show member pathways
 12.43 HLA-C HLA-B HLA-A
6
Herpes simplex virus 1 infection 36
12.4 HLA-C HLA-B HLA-A
7
Interferon gamma signaling 65
Show member pathways
 12.16 HLA-C HLA-B HLA-A
8
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.13 HLA-C HLA-B HLA-A
9
Antigen processing-Cross presentation 65
Show member pathways
 12.08 HLA-C HLA-B HLA-A
10
Endocytosis 36
12.01 HLA-C HLA-B HLA-A
11
Human T-cell leukemia virus 1 infection 36
11.92 HLA-C HLA-B HLA-A
12
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.9 HLA-C HLA-B HLA-A
13
Viral carcinogenesis 36
11.85 HLA-C HLA-B HLA-A
14
Cellular senescence (KEGG) 36
11.69 HLA-C HLA-B HLA-A
15
Phagosome 36
11.61 HLA-C HLA-B HLA-A
16
Cell adhesion molecules 36
11.51 HLA-C HLA-B HLA-A
17
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.26 HLA-C HLA-B HLA-A
18
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 65
10.2 HLA-C HLA-B HLA-A
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GO Terms for Epstein-Barr Virus Hepatitis

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Cellular components related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 HLA-C HLA-B HLA-A GOT1 AHSG
2 Golgi apparatus GO:0005794 9.73 HLA-C HLA-B HLA-A AHSG
3 Golgi membrane GO:0000139 9.67 HLA-C HLA-B HLA-A
4 cell surface GO:0009986 9.65 HLA-C HLA-B HLA-A
5 early endosome membrane GO:0031901 9.54 HLA-C HLA-B HLA-A
6 recycling endosome membrane GO:0055038 9.5 HLA-C HLA-B HLA-A
7 secretory granule membrane GO:0030667 9.46 HLA-C HLA-B
8 phagocytic vesicle membrane GO:0030670 9.43 HLA-C HLA-B HLA-A
9 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-C HLA-B HLA-A
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-C HLA-B HLA-A
11 MHC class I protein complex GO:0042612 8.8 HLA-C HLA-B HLA-A

Biological processes related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.73 HLA-C HLA-B HLA-A
2 viral process GO:0016032 9.72 HLA-C HLA-B HLA-A
3 immune response GO:0006955 9.71 HLA-C HLA-B HLA-A
4 neutrophil degranulation GO:0043312 9.7 HLA-C HLA-B AHSG
5 adaptive immune response GO:0002250 9.69 HLA-C HLA-B HLA-A
6 regulation of immune response GO:0050776 9.65 HLA-C HLA-B HLA-A
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.58 HLA-C HLA-B HLA-A
8 interferon-gamma-mediated signaling pathway GO:0060333 9.54 HLA-C HLA-B HLA-A
9 type I interferon signaling pathway GO:0060337 9.5 HLA-C HLA-B HLA-A
10 positive regulation of T cell mediated cytotoxicity GO:0001916 9.49 HLA-B HLA-A
11 detection of bacterium GO:0016045 9.46 HLA-B HLA-A
12 protection from natural killer cell mediated cytotoxicity GO:0042270 9.43 HLA-B HLA-A
13 antigen processing and presentation GO:0019882 9.43 HLA-C HLA-B HLA-A
14 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.33 HLA-C HLA-B HLA-A
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.13 HLA-C HLA-B HLA-A
16 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 8.8 HLA-C HLA-B HLA-A

Molecular functions related to Epstein-Barr Virus Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-C HLA-B HLA-A
2 TAP binding GO:0046977 8.8 HLA-C HLA-B HLA-A
Sources

Sources for Epstein-Barr Virus Hepatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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