MCID: ERY004
MIFTS: 43

Erysipelas

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 76 53 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD10 33 A46
ICD9CM 35 035
MeSH 44 D004886
UMLS 73 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to elephantiasis and brucellosis, and has symptoms including exanthema An important gene associated with Erysipelas is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Folate Metabolism and Detoxification of Reactive Oxygen Species. The drugs Penicillin V and Daptomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast.

Wikipedia : 76 Erysipelas is an acute infection typically with a skin rash, usually on any of the legs and toes, face,... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 elephantiasis 30.5 ELANE ELN
2 brucellosis 30.5 MEFV TNF
3 pyoderma gangrenosum 30.0 MEFV TNF
4 pyoderma 30.0 MEFV TNF
5 vasculitis 30.0 ELANE MEFV TNF
6 familial mediterranean fever 29.7 MEFV TNF
7 impetigo 29.2 CALCA ELANE PI3
8 skin disease 29.1 CAT PI3 TNF
9 pneumonia 29.0 ELANE PIK3C2A TNF
10 endocarditis 28.9 PIK3C2A TNF
11 arthus reaction 10.6 ELANE TNF
12 acute vascular insufficiency of intestine 10.6 SOD1 TNF
13 pustulosis palmaris et plantaris 10.6 ELANE TNF
14 eales disease 10.6 SOD1 TNF
15 spinal cord disease 10.6 SOD1 TNF
16 meningitis and encephalitis 10.5 CAT SOD1
17 leukocyte disease 10.5 ELANE TNF
18 systemic onset juvenile idiopathic arthritis 10.5 MEFV TNF
19 autoinflammation, panniculitis, and dermatosis syndrome 10.5 MEFV TNF
20 bronchopulmonary dysplasia 10.5 ELANE SOD1
21 complex regional pain syndrome 10.5 CALCA TNF
22 lichen sclerosus 10.5 ELN TNF
23 relapsing fever 10.5 MEFV TNF
24 cerebral aneurysms 10.5 ELANE ELN
25 mid-dermal elastolysis 10.5 ELANE ELN
26 periodic fever, familial, autosomal dominant 10.5 MEFV TNF
27 tonsillitis 10.4 SOD1 TNF
28 myocardial stunning 10.4 CAT SOD1
29 chorioamnionitis 10.4 ELANE TNF
30 blau syndrome 10.4 MEFV TNF
31 adult-onset still's disease 10.4 MEFV TNF
32 aphthous stomatitis 10.4 MEFV TNF
33 palindromic rheumatism 10.4 MEFV TNF
34 cellulitis 10.4
35 pleurisy 10.4 MEFV TNF
36 irritant dermatitis 10.3 PI3 TNF
37 alpha-1-antitrypsin deficiency 10.3 ELANE ELN
38 pasteurellosis 10.3 ELANE PI3
39 gingivitis 10.3 ELANE TNF
40 impetigo herpetiformis 10.3 ELANE PI3
41 pericarditis 10.3 MEFV TNF
42 bronchopneumonia 10.3 ELANE PI3
43 engraftment syndrome 10.3 CALCA PI3
44 arthritis 10.2
45 pulmonary emphysema 10.2 ELANE ELN
46 retinal ischemia 10.1 CAT SOD1 TNF
47 pneumoconiosis 10.1 CAT SOD1 TNF
48 netherton syndrome 10.1 ELANE PI3
49 adult respiratory distress syndrome 10.1 ELANE ELN TNF
50 wegener granulomatosis 10.1 ELANE ELN TNF

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
3
Vancomycin Approved Phase 4 1404-90-6 441141 14969
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5 Anti-Bacterial Agents Phase 4,Phase 2
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 2
8 penicillins Phase 4
9 Antitubercular Agents Phase 4
10 Floxacillin Phase 4
11
Menthol Approved Phase 3,Not Applicable 2216-51-5 16666
12 Torezolid Phase 2
13 Torezolid phosphate Phase 2
14
Linezolid Approved, Investigational 165800-03-3 441401
15
Dimenhydrinate Approved Not Applicable 523-87-5 441281
16 methicillin
17 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
2 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Short Course of Amoxicillin for Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
4 Duration of ANtibiotic Therapy for CEllulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
5 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
6 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study Completed NCT01519778 Phase 2 TR701 FA
7 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
8 Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections Completed NCT02052388 Phase 2 Daptomycin;Brilacidin
9 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Recruiting NCT02981485 Phase 2
10 The Use of Oral Steroids in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
11 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
12 Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Recruiting NCT02991131 Tedizolid (Sivextro, BAY 11-70438);Linezolid
13 Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Recruiting NCT02609724 Not Applicable
14 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable
15 The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever. Withdrawn NCT02021084 Not Applicable

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 29

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

41
Skin, Testes, Breast, Colon, B Cells, Neutrophil, Pituitary

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 551)
# Title Authors Year
1
Dacryocystitis mimicking erysipelas due to a giant dacryolith. ( 29655289 )
2018
2
<i>Erysipelothrix rhusiopathiae</i> serotype 15 associated with recurring pig erysipelas outbreaks. ( 29519854 )
2018
3
Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas. ( 29578137 )
2018
4
Trends in the epidemiology of erysipelas in Slovenia. ( 29589637 )
2018
5
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
6
Recurrent erysipelas of the face with hyperimmune reaction to group C streptococcus. ( 29526042 )
2018
7
Corticosteroid Therapy in Combination with Antibiotics for Erysipelas. ( 29527848 )
2018
8
INDEXES OF CYTOKINE PROFILE OF BLOOD IN PATIENTS WITH COMPLICATED ERYSIPELAS. ( 29461220 )
2018
9
Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. ( 28314730 )
2017
10
Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. ( 28477399 )
2017
11
Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease. ( 28741584 )
2017
12
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan. ( 27773881 )
2017
13
Interventions for the prevention of recurrent erysipelas and cellulitis. ( 28631307 )
2017
14
Benzathine penicillin G once-every-3-week prophylaxis for recurrent erysipelas a retrospective study of 132 patients. ( 28489486 )
2017
15
Single nucleotide polymorphism genotyping of Erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in Japan. ( 28250289 )
2017
16
Bilateral Milian's Ear Sign of Erysipelas. ( 28794379 )
2017
17
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
18
Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients. ( 28512644 )
2017
19
Risk factors associated with local complications of erysipelas: a retrospective study of 152 cases. ( 28451043 )
2017
20
The Myth of Erysipelas-Fire, Water, and Blood. ( 28114522 )
2017
21
Familial Mediterranean fever patients may have unmet need for treatment of erysipelas-like erythema. ( 27782864 )
2016
22
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
23
Complete genome sequence of Erysipelothrix rhusiopathiae strain GXBY-1 isolated from acute swine erysipelas outbreaks in south China. ( 27222802 )
2016
24
A Fatal Case of &amp;quot;Bullous Erysipelas-like&amp;quot; Pseudomonas Vasculitis. ( 26955132 )
2016
25
Complicated Skin and Skin Structure Infection After Erysipelas: Urgent Need for Antibiosis and Surgery. ( 26933116 )
2016
26
Clinical and epidemiological assessment of patients hospitalized for primary and recurrent erysipelas ( 28221013 )
2016
27
The effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on swine humoral immune response induced by erysipelas vaccination. ( 27072375 )
2016
28
High Incidence of Erysipelas After Surgical Treatment for Vulvar Carcinoma: An Observational Study. ( 26807636 )
2016
29
Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection. ( 26791960 )
2016
30
How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review. ( 27765000 )
2016
31
Low sensitivity of needle aspiration cultures in patients with cellulitis/erysipelas. ( 27652151 )
2016
32
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
33
Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas. ( 27085865 )
2016
34
Erysipelas, a large retrospective study of aetiology and clinical presentation. ( 26424182 )
2015
35
Risk factors associated with a reduced response in the treatment of erysipelas. ( 25706926 )
2015
36
Erysipelas in turkeys, sheep and pigs. ( 25792678 )
2015
37
Risk factors associated with abscess formation among patient with leg erysipelas (cellulitis) in sub-Saharan Africa: a multicenter study. ( 26666633 )
2015
38
Erysipelas Outbreaks in Flocks of Geese in Poland--Biochemical and Genetic Analyses of the Isolates. ( 26478164 )
2015
39
Characterization of &amp;lt;i&amp;gt;Erysipelothrix rhusiopathiae&amp;lt;/i&amp;gt; strains isolated from acute swine erysipelas outbreaks in Eastern China. ( 25649849 )
2015
40
Safety and efficacy of a new octavalent combined Erysipelas, Parvo and Leptospira vaccine in gilts against Leptospira interrogans serovar Pomona associated disease and foetal death. ( 26100922 )
2015
41
Synergic effect of erysipelas on aggression to the lymphatic system in patients submitted to the excision of a saphenous vein. ( 26344512 )
2015
42
Diagnosis and management of cellulitis and erysipelas. ( 26255928 )
2015
43
Cellulitis and erysipelas: prevention. ( 26580894 )
2015
44
Pseudo-kaposi sarcoma (acroangiodermatitis): occurring after bullous erysipelas. ( 26295854 )
2015
45
Use of procalcitonin, C-reactive protein and white blood cell count to distinguish between lower limb erysipelas and deep vein thrombosis in the emergency department: A prospective observational study. ( 25982244 )
2015
46
Endogenous endophthalmitis secondary to erysipelas. ( 26123459 )
2015
47
Unusual presentation of chikungunya virus infection with concomintant erysipelas in a returning traveler from the Caribbean: a case report. ( 25734165 )
2014
48
Prevalence of Met-203 type spaA variant in Erysipelothrix rhusiopathiae isolates and the efficacy of swine erysipelas vaccines in Japan. ( 24405986 )
2014
49
Erysipelas-like Erythema in a Patient with Familial Mediterranean Fever. ( 25362709 )
2014
50
An unusual erysipelas-like presentation. ( 24456958 )
2014

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CAT ELANE SOD1 TNF
2 extracellular region GO:0005576 9.17 CALCA CAT ELANE ELN PI3 SOD1

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of smooth muscle cell proliferation GO:0048661 9.51 ELANE TNF
2 antimicrobial humoral response GO:0019730 9.49 ELANE PI3
3 response to hydrogen peroxide GO:0042542 9.48 CAT SOD1
4 response to UV GO:0009411 9.46 CAT ELANE
5 response to heat GO:0009408 9.43 CALCA SOD1
6 aging GO:0007568 9.43 CALCA CAT SOD1
7 embryo implantation GO:0007566 9.4 CALCA SOD1
8 positive regulation of cytokine production GO:0001819 9.37 SOD1 TNF
9 positive regulation of interleukin-8 production GO:0032757 9.32 CALCA TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.16 ELANE TNF
11 response to reactive oxygen species GO:0000302 8.96 CAT SOD1
12 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 ELANE TNF

Molecular functions related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.62 CAT SOD1

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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