MCID: ERY004
MIFTS: 47

Erysipelas

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 73 20 29 54 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD9CM 34 035
MeSH 44 D004886
SNOMED-CT 67 266005008
ICD10 32 A46
UMLS 70 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to cellulitis and pasteurellosis, and has symptoms including exanthema An important gene associated with Erysipelas is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are NOD-like receptor signaling pathway and C-type lectin receptor signaling pathway. The drugs Penicillin V and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and heart, and related phenotypes are immune system and integument

Wikipedia : 73 Erysipelas is a relatively common bacterial infection of the superficial layer of the skin (upper... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 747)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.7 TNF MYOM2 IL6 CRP
2 pasteurellosis 30.4 TNF PI3 ELANE
3 fasciitis 30.3 TNF MYOM2 IL6 IL2
4 scarlet fever 30.3 TNF MYOM2 CRP
5 enthesopathy 30.2 TNF MEFV CRP
6 familial mediterranean fever 30.2 TNF MVK MEFV IL6 IL1B CRP
7 endocarditis 30.0 TNF PIK3C2A IL6 CRP
8 neurogenic arthropathy 29.9 CRP CALCA
9 vasculitis 29.9 TNF MEFV IL6 ELANE CRP
10 bullous impetigo 29.9 IL6 CALCA
11 hemopericardium 29.8 ELN CRP
12 pyoderma gangrenosum 29.8 TNF MVK MEFV
13 purpura 29.8 TNF MEFV IL6 CRP
14 impetigo 29.8 PI3 MYOM2 IL6 ELANE CALCA
15 brucellosis 29.7 TNF MEFV IL6 IL2 CRP
16 vitiligo-associated multiple autoimmune disease susceptibility 1 29.7 TNF IL2 CAT
17 disseminated intravascular coagulation 29.7 TNF PIK3C2A IL6 ELANE CRP
18 varicose veins 29.7 TNF IL6 ELN
19 dermatitis 29.7 TNF IL6 IL2 IL1B
20 panuveitis 29.6 TNF IL6 CRP
21 pyomyositis 29.6 PIK3C2A MYOM2 CRP
22 chronic urticaria 29.6 TNF IL6 CRP
23 peripheral artery disease 29.6 TNF IL6 CRP
24 irritant dermatitis 29.5 TNF IL6 IL1B
25 pericardial effusion 29.5 PIK3C2A IL6 CRP
26 plague 29.5 TNF IL6 IL2 IL1B
27 bacterial infectious disease 29.5 TNF IL6 IL1B ELANE CRP
28 chickenpox 29.5 TNF IL6 IL2 CRP
29 typhoid fever 29.4 TNF IL6 IL1B CRP
30 necrotizing fasciitis 29.4 MYOM2 IL6 IL2 IL1B CRP
31 compartment syndrome 29.4 TNF PIK3C2A IL6 CRP
32 relapsing polychondritis 29.4 IL6 IL2 CRP
33 pleurisy 29.4 TNF MEFV IL2 CRP
34 carbuncle 29.3 TNF IL6 IL1B
35 lymphadenitis 29.3 TNF IL1B CRP
36 allergic disease 29.3 TNF IL6 IL2 IL1B
37 bursitis 29.3 TNF IL6 IL1B CRP CALCA
38 contact dermatitis 29.3 TNF IL6 IL2 IL1B
39 leishmaniasis 29.3 TNF IL6 IL2 IL1B
40 chikungunya 29.2 TNF IL6 IL1B
41 cystitis 29.2 TNF IL6 IL2 CRP
42 synovitis 29.2 TNF IL6 IL1B CRP
43 filariasis 29.2 TNF IL6 IL2 CRP
44 endophthalmitis 29.2 TNF IL6 IL1B CRP
45 erythema nodosum 29.2 TNF IL6 IL1B CRP
46 rheumatic fever 29.2 TNF MYOM2 IL6 IL2
47 prosthetic joint infection 29.2 IL6 IL1B CRP
48 neutrophilic dermatosis, acute febrile 29.1 TNF MEFV IL1B CRP
49 aspergillosis 29.1 TNF IL6 IL1B ELANE
50 pyoderma 29.1 TNF MYOM2 MEFV IL1B CRP

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

MGI Mouse Phenotypes related to Erysipelas:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.9 BDKRB1 CRP ELANE IL1B IL2 IL6
2 integument MP:0010771 9.61 BDKRB1 ELANE IL1B IL6 MEFV MYOM2
3 neoplasm MP:0002006 9.23 CAT ELANE IL1B IL2 IL6 SOD1

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Vancomycin Approved Phase 4 1404-90-6 441141 14969
3
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5 penicillins Phase 4
6 Floxacillin Phase 4
7 Anti-Bacterial Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9 Anti-Infective Agents Phase 4
10
Tedizolid Approved, Investigational Phase 2 856866-72-3
11
Tedizolid phosphate Approved Phase 2 856867-55-5
12 Dermatologic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomised Controlled Trial to Investigate Whether Prophylactic Antibiotics Can Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg (PATCH I) Completed NCT00552799 Phase 4 Penicillin VK
2 A Multicenter, Randomized Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in the Treatment of Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Duration of Antibiotic Therapy for Cellulitis (DANCE): a Randomized Controlled Trial Comparing 6 to 12 Days of Antibiotic Therapy for Patients Hospitalized With Cellulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
4 Randomized Non Inferiority Study Comparing Short Course of Oral Amoxicillin to One of the Usual Treatments of Lower Leg Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
5 Phase 2 Open-Label Safety and Exploratory Skin Lesion Measurement Study of 6-Day Oral TR-701 FA in Skin Abscess and Cellulitis Patients Completed NCT01519778 Phase 2 TR701 FA
6 Utility of Prednisone in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
7 Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever Unknown status NCT03917277
8 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822
9 Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis (DHBN-FN) Mono- or Multi-microbial Streptococcus Beta-haemolytic: Study of Carriage in Patients and Their Entourage Not yet recruiting NCT03976024

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 29

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

40
Skin, Bone, Heart, Lung, Kidney, Lymph Node, Liver

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 2197)
# Title Authors PMID Year
1
The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis. 54 61
15482296 2004
2
The importance of serum creatine phosphokinase level in the early diagnosis, and as a prognostic factor, of Vibrio vulnificus infection. 54 61
11531792 2001
3
Levels of skin-derived antileukoproteinase (SKALP)/elafin in serum correlate with disease activity during treatment of severe psoriasis with cyclosporin A. 61 54
7829874 1995
4
Bone SPECT/CT in the Evaluation of Painful Total Ankle Replacement: Validation of Localization Scheme and Preliminary Evaluation of Diagnostic Patterns. 61
33630798 2021
5
In vitro antiplatelet activity of extract and its fractions of Paulownia Clone in Vitro 112 leaves. 61
33561640 2021
6
Beta-hemolytic streptococci A, C and G are susceptible to cloxacillin. 61
33797809 2021
7
[Bacterial acute non necrosing cellulitis (erysipelas) in adult]. 61
33176944 2021
8
Presentation of a new mutation in FMF and evaluating the frequency of distribution of the MEFV gene mutation in our region with clinical findings. 61
33738724 2021
9
Quantification of IgY to Erysipelothrix rhusiopathiae in serum from Swedish laying hens. 61
33676514 2021
10
First Report of Leaf Spot of Weigela florida Caused by Epicoccum layuense in China. 61
33754867 2021
11
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
12
First Report of Genetic Variability of Erysipelothrix sp. Strain 2 in Turkeys Associated to Vero Cells Morphometric Alteration. 61
33535396 2021
13
Fungal infections of the feet in patients with erysipelas of the lower limb: is it a significant clinical problem? 61
33534066 2021
14
A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting. 61
33535501 2021
15
Risk factors associated with necrotizing fasciitis of the lower limbs: A multicenter case-control study. 61
33558036 2021
16
Recent Advances in Cancer Immunotherapy. 61
33672298 2021
17
Erysipelas over the centuries: notes from the history of popes. 61
33417124 2021
18
[Is compression therapy contraindicated for lower leg erysipelas? : Results of a retrospective analysis]. 61
32930854 2021
19
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus. 61
33777005 2021
20
Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study. 61
33413190 2021
21
Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins). 61
33407666 2021
22
Age of onset as an influencing factor for disease severity in children with familial Mediterranean fever. 61
31999206 2021
23
Antibacterial activity of methanol extracts of the leaves of three medicinal plants against selected bacteria isolated from wounds of lymphoedema patients. 61
33390165 2021
24
Serovars and SpaA Types of Erysipelothrix rhusiopathiae Isolated from Pigs in Japan from 2012 to 2019. 61
33145611 2021
25
Infectious diseases of the skin in contact sports. 61
33389840 2020
26
Diagnostic value of laboratory parameters for the discrimination between erysipelas and limited cellulitis. 61
33035396 2020
27
Long-term risk of dementia following hospitalization due to physical diseases: A multicohort study. 61
32886434 2020
28
Polyarthritis caused by Erysipelothrix rhusiopathiae in three Austrian sheep flocks - diagnosis, treatment and management measures. 61
33263544 2020
29
Retrospective Summary of Erysipelothrix rhusiopathiae Diagnosed in Avian Species in California (2000-19). 61
33570103 2020
30
Draft genome sequence data of Erysipelothrix rhusiopathiae vaccine strain VR-2. 61
33083506 2020
31
Burden, risk factors, and infectious complications of cellulitis and erysipelas in US adults and children in the emergency department setting. 61
33238162 2020
32
Does Age at Onset Affect the Clinical Presentation of Familial Mediterranean Fever in Children? 61
33252389 2020
33
Atypical and unusual morphological variants of cutaneous leishmaniasis. 61
33107120 2020
34
A second C-reactive protein (CRP) test to detect inflammatory burst in patients with acute bacterial infections presenting with a first relatively low CRP. 61
33080689 2020
35
A Retrospective Study after 10 Years (2010-2019) of Meat Inspection Activity in a Domestic Swine Abattoir in Tuscany: The Slaughterhouse as an Epidemiological Observatory. 61
33080947 2020
36
An invasive infection with an unusual spaB-possessing Erysipelothrix rhusiopathiae in a human. 61
32924920 2020
37
Four cases of erysipelas-like inflammation in patients with metastatic melanoma treated with checkpoint inhibitors. 61
33029897 2020
38
Erysipelas Complicated with Acute Exudative Pericarditis. 61
33138010 2020
39
Current trends in the real-life use of dalbavancin: report of a study panel. 61
32721599 2020
40
Draft genome sequence data and comparative analysis of Erysipelothrix Rhusiopathiae vaccine strain VR-2. 61
33088652 2020
41
Facial Erysipelas After Secukinumab Therapy. 61
30139691 2020
42
Potential risk factors of swine erysipelas outbreak in Northeast Mainland China. 61
32965781 2020
43
Shaving Technique and Compression Therapy for Elephantiasis Nostras Verrucosa (Lymphostatic Verrucosis) of Forefeet and Toes in End-Stage Primary Lymphedema: A 5 Year Follow-Up Study in 28 Patients and a Review of the Literature. 61
32998425 2020
44
Erysipelas-like erythema in children with familial Mediterranean fever. 61
33124556 2020
45
Phase 1 LymfactinⓇ Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema. 61
32513642 2020
46
One holy man, one eponym, three distinct diseases. St. Anthony's fire revisited. 61
33682839 2020
47
Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens. 61
32928307 2020
48
55-year old woman with erysipelas. 61
32994788 2020
49
Comparative genome analysis of Erysipelothrix rhusiopathiae isolated from domestic pigs and wild boars suggests host adaptation and selective pressure from the use of antibiotics. 61
32735209 2020
50
Milian's ear sign of erysipelas. 61
32241881 2020

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

Pathways related to Erysipelas according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1 12.18 TNF MEFV IL6 IL1B
2
Show member pathways
12.14 TNF IL6 IL2 IL1B
3 11.87 TNF IL6 IL2 IL1B
4 11.86 TNF MEFV IL6 IL2 IL1B
5 11.8 TNF IL6 IL1B
6 11.72 TNF IL2 IL1B
7 11.69 TNF IL6 IL1B
8 11.67 SOD2 SOD1 MVK CAT
9
Show member pathways
11.61 TNF IL6 IL2 IL1B
10 11.57 TNF IL6 IL2 IL1B
11 11.56 TNF IL6 IL1B
12
Show member pathways
11.56 TNF SOD2 SOD1 IL6 IL2 IL1B
13
Show member pathways
11.54 SOD2 SOD1 CAT
14 11.49 TNF IL6 IL2
15 11.48 TNF IL6 IL1B
16
Show member pathways
11.47 TNF IL6 IL2 IL1B
17 11.46 TNF IL6 IL1B
18 11.44 TNF IL2 IL1B
19 11.43 TNF IL6 ELANE
20 11.32 TNF SOD1 CAT
21 11.3 TNF IL6 IL1B
22 11.27 TNF IL6 IL1B
23 11.22 TNF IL6 IL1B
24 11.21 TNF IL6 IL1B CALCA
25 11.19 SOD2 SOD1 CAT
26 11.18 TNF IL6 IL1B
27 11.15 TNF IL6 IL1B ELN CALCA
28 10.94 TNF IL6 IL2 IL1B ELN
29 10.93 TNF IL6 CRP
30 10.92 TNF IL6 IL2 IL1B
31 10.73 IL6 IL1B

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF SOD1 PI3 IL6 IL2 IL1B
2 extracellular region GO:0005576 9.4 TNF SOD1 PI3 IL6 IL2 IL1B

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.06 TNF IL6 IL1B CRP AZU1
2 negative regulation of apoptotic process GO:0043066 9.97 SOD2 SOD1 IL6 IL2 CAT AZU1
3 aging GO:0007568 9.91 SOD2 SOD1 CAT CALCA
4 response to lipopolysaccharide GO:0032496 9.89 SOD2 IL1B ELANE BDKRB1
5 positive regulation of inflammatory response GO:0050729 9.85 TNF IL2 IL1B
6 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TNF IL6 IL1B CAT
8 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IL1B
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 TNF IL6 IL2
10 regulation of blood pressure GO:0008217 9.82 SOD2 SOD1 CALCA
11 positive regulation of interferon-gamma production GO:0032729 9.81 TNF IL2 IL1B
12 positive regulation of T cell proliferation GO:0042102 9.81 IL6 IL2 IL1B
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 TNF IL6 ELANE
14 antimicrobial humoral response GO:0019730 9.8 PI3 ELANE AZU1
15 response to hydrogen peroxide GO:0042542 9.79 SOD2 SOD1 CAT
16 positive regulation of interleukin-1 beta production GO:0032731 9.79 TNF IL6 AZU1
17 response to activity GO:0014823 9.77 SOD2 IL6 CAT
18 embryo implantation GO:0007566 9.7 SOD1 IL1B CALCA
19 removal of superoxide radicals GO:0019430 9.67 SOD2 SOD1
20 negative regulation of chemokine production GO:0032682 9.67 IL6 ELANE
21 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
22 hydrogen peroxide biosynthetic process GO:0050665 9.65 SOD2 SOD1
23 protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205 9.65 IL2 BDKRB1 AZU1
24 negative regulation of inflammatory response GO:0050728 9.65 SOD1 MVK MEFV IL2 ELANE
25 negative regulation of neurogenesis GO:0050768 9.63 TNF IL6 IL1B
26 positive regulation of phagocytosis GO:0050766 9.62 TNF SOD1 IL1B AZU1
27 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
28 cellular extravasation GO:0045123 9.58 TNF AZU1
29 response to L-ascorbic acid GO:0033591 9.58 SOD2 CAT
30 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
31 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
32 response to superoxide GO:0000303 9.56 SOD2 SOD1
33 sequestering of triglyceride GO:0030730 9.54 TNF IL1B
34 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
36 positive regulation of interleukin-8 production GO:0032757 9.35 TNF IL6 IL1B ELANE CALCA
37 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
38 inflammatory response GO:0006954 9.23 TNF MEFV IL6 IL1B CRP CALCA

Molecular functions related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL6 IL2 IL1B
2 identical protein binding GO:0042802 9.23 TNF SOD2 SOD1 MVK MEFV CRP
3 superoxide dismutase activity GO:0004784 8.96 SOD2 SOD1

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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