MCID: ERY004
MIFTS: 47

Erysipelas

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 76 53 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD10 33 A46
ICD9CM 35 035
MeSH 44 D004886
SNOMED-CT 68 44653001
UMLS 73 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to familial mediterranean fever and vasculitis, and has symptoms including exanthema An important gene associated with Erysipelas is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Longevity regulating pathway and DNA Damage Response (only ATM dependent). The drugs Penicillin V and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia : 76 Erysipelas is an acute infection typically with a skin rash, usually on any of the legs and toes, face,... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 familial mediterranean fever 30.2 MEFV TNF
2 vasculitis 30.1 ELANE MEFV TNF
3 pyoderma gangrenosum 29.8 MEFV TNF
4 pyoderma 29.8 MEFV TNF
5 pleurisy 29.8 MEFV TNF
6 pneumonia 29.7 ELANE PIK3C2A TNF
7 skin disease 29.5 CAT PI3 TNF
8 impetigo 29.5 CALCA ELANE PI3
9 endocarditis 29.3 PIK3C2A TNF
10 cellulitis 10.5
11 arthritis 10.4
12 lymphedema 10.2
13 arthus reaction 10.2 ELANE TNF
14 periodontosis 10.2 ELANE TNF
15 pustulosis palmaris et plantaris 10.2 ELANE TNF
16 anthracosis 10.2 SOD1 TNF
17 aseptic meningitis 10.2 SOD2 TNF
18 meningitis and encephalitis 10.2 CAT SOD1
19 thrombosis 10.2
20 eales disease 10.2 SOD1 TNF
21 systemic onset juvenile idiopathic arthritis 10.2 MEFV TNF
22 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
23 juvenile ankylosing spondylitis 10.2 MEFV TNF
24 type 1 diabetes mellitus 10 10.2 CAT SOD2
25 relapsing fever 10.1 MEFV TNF
26 periodic fever, familial, autosomal dominant 10.1 MEFV TNF
27 japanese encephalitis 10.1 SOD1 TNF
28 myocardial stunning 10.1 CAT SOD1
29 adult respiratory distress syndrome 10.1 ELANE TNF
30 hypersensitivity reaction type iii disease 10.1 MEFV TNF
31 blau syndrome 10.1 MEFV TNF
32 erysipeloid 10.1
33 bronchopulmonary dysplasia 10.1 ELANE SOD1
34 adult-onset still's disease 10.1 MEFV TNF
35 palindromic rheumatism 10.1 MEFV TNF
36 complex regional pain syndrome 10.1 CALCA TNF
37 trichuriasis 10.1 PI3 TNF
38 irritant dermatitis 10.1 PI3 TNF
39 aphthous stomatitis 10.1 MEFV TNF
40 tonsillitis 10.1 SOD1 TNF
41 impetigo herpetiformis 10.1 ELANE PI3
42 chorioamnionitis 10.1 ELANE TNF
43 bronchopneumonia 10.1 ELANE PI3
44 pericarditis 10.1 MEFV TNF
45 brucellosis 10.1 MEFV TNF
46 breast cancer 10.1
47 scarlet fever 10.1
48 fasciitis 10.1
49 gingivitis 10.1 ELANE TNF
50 netherton syndrome 10.1 ELANE PI3

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

MGI Mouse Phenotypes related to Erysipelas:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 CAT ELANE MEFV PIK3C2A SOD1 SOD2
2 neoplasm MP:0002006 9.02 CAT ELANE SOD1 SOD2 TNF

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Vancomycin Approved Phase 4 1404-90-6 14969 441141
3
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5 penicillins Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 2
8 Anti-Bacterial Agents Phase 4,Phase 2
9 Floxacillin Phase 4
10 Antitubercular Agents Phase 4
11
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
12
leucovorin Approved Phase 2 58-05-9 6006 143
13
Trimethoprim Approved, Vet_approved Phase 2 738-70-5 5578
14
Sulfamethoxazole Approved Phase 2 723-46-6 5329
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
16 Torezolid phosphate Phase 2
17 Torezolid Phase 2
18 Folate Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 2
20 Anti-Infective Agents, Urinary Phase 2
21 Vitamin B9 Phase 2
22 Vitamin B Complex Phase 2
23 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
24 Folic Acid Antagonists Phase 2
25 Antiparasitic Agents Phase 2
26 Antiprotozoal Agents Phase 2
27 Antimalarials Phase 2
28 Renal Agents Phase 2
29
Dimenhydrinate Approved Not Applicable 523-87-5 441281
30
Linezolid Approved, Investigational 165800-03-3 441401
31 Dermatologic Agents Not Applicable
32 methicillin

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
2 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Short Course of Amoxicillin for Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
4 Duration of ANtibiotic Therapy for CEllulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
5 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
6 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Unknown status NCT02981485 Phase 2
7 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study Completed NCT01519778 Phase 2 TR701 FA
8 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
9 Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections Completed NCT02052388 Phase 2 Daptomycin;Brilacidin
10 Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment Not yet recruiting NCT03637400 Phase 2 TMP-SMX;DOXY
11 The Use of Oral Steroids in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
12 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
13 Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Recruiting NCT02609724 Not Applicable
14 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable
15 Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Terminated NCT02991131 Tedizolid (Sivextro, BAY 11-70438);Linezolid
16 The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever. Withdrawn NCT02021084 Not Applicable

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 29

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

41
Skin, Testes, Breast, Bone, Thyroid, B Cells, Lung

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 662)
# Title Authors Year
1
Dacryocystitis mimicking erysipelas due to a giant dacryolith. ( 29655289 )
2018
2
<i>Erysipelothrix rhusiopathiae</i> serotype 15 associated with recurring pig erysipelas outbreaks. ( 29519854 )
2018
3
Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas. ( 29578137 )
2018
4
Trends in the epidemiology of erysipelas in Slovenia. ( 29589637 )
2018
5
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
6
Recurrent erysipelas of the face with hyperimmune reaction to group C streptococcus. ( 29526042 )
2018
7
Corticosteroid Therapy in Combination with Antibiotics for Erysipelas. ( 29527848 )
2018
8
INDEXES OF CYTOKINE PROFILE OF BLOOD IN PATIENTS WITH COMPLICATED ERYSIPELAS. ( 29461220 )
2018
9
Erysipelas or cellulitis with a prosthetic joint in situ. ( 30416947 )
2018
10
Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis. ( 30535927 )
2018
11
Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice. ( 29992162 )
2018
12
A Case of Recurrent Erysipelas Caused by Streptococcus mitis Group. ( 30018832 )
2018
13
Facial Erysipelas After Secukinumab Therapy. ( 30139691 )
2018
14
Milian's ear sign: Erysipelas. ( 30191132 )
2018
15
Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs. ( 30210067 )
2018
16
Management of necrotizing and non-necrotic bacterial erysipelas of the face in tropical areas: a series of four cases and a review of the literature. ( 30270829 )
2018
17
A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas. ( 30519119 )
2018
18
Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. ( 28314730 )
2017
19
Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. ( 28477399 )
2017
20
Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease. ( 28741584 )
2017
21
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan. ( 27773881 )
2017
22
Interventions for the prevention of recurrent erysipelas and cellulitis. ( 28631307 )
2017
23
Benzathine penicillin G once-every-3-week prophylaxis for recurrent erysipelas a retrospective study of 132 patients. ( 28489486 )
2017
24
Single nucleotide polymorphism genotyping of Erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in Japan. ( 28250289 )
2017
25
Bilateral Milian's Ear Sign of Erysipelas. ( 28794379 )
2017
26
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
27
Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients. ( 28512644 )
2017
28
Risk factors associated with local complications of erysipelas: a retrospective study of 152 cases. ( 28451043 )
2017
29
The Myth of Erysipelas-Fire, Water, and Blood. ( 28114522 )
2017
30
Familial Mediterranean fever patients may have unmet need for treatment of erysipelas-like erythema. ( 27782864 )
2016
31
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
32
Complete genome sequence of Erysipelothrix rhusiopathiae strain GXBY-1 isolated from acute swine erysipelas outbreaks in south China. ( 27222802 )
2016
33
A Fatal Case of &amp;quot;Bullous Erysipelas-like&amp;quot; Pseudomonas Vasculitis. ( 26955132 )
2016
34
Complicated Skin and Skin Structure Infection After Erysipelas: Urgent Need for Antibiosis and Surgery. ( 26933116 )
2016
35
Clinical and epidemiological assessment of patients hospitalized for primary and recurrent erysipelas ( 28221013 )
2016
36
The effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on swine humoral immune response induced by erysipelas vaccination. ( 27072375 )
2016
37
High Incidence of Erysipelas After Surgical Treatment for Vulvar Carcinoma: An Observational Study. ( 26807636 )
2016
38
Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection. ( 26791960 )
2016
39
How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review. ( 27765000 )
2016
40
Low sensitivity of needle aspiration cultures in patients with cellulitis/erysipelas. ( 27652151 )
2016
41
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
42
Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas. ( 27085865 )
2016
43
Liposuction of Postmastectomy Arm Lymphedema Decreases the Incidence of Erysipelas. ( 29906366 )
2016
44
Erysipelas, a large retrospective study of aetiology and clinical presentation. ( 26424182 )
2015
45
Risk factors associated with a reduced response in the treatment of erysipelas. ( 25706926 )
2015
46
Erysipelas in turkeys, sheep and pigs. ( 25792678 )
2015
47
Risk factors associated with abscess formation among patient with leg erysipelas (cellulitis) in sub-Saharan Africa: a multicenter study. ( 26666633 )
2015
48
Erysipelas Outbreaks in Flocks of Geese in Poland--Biochemical and Genetic Analyses of the Isolates. ( 26478164 )
2015
49
Characterization of &amp;lt;i&amp;gt;Erysipelothrix rhusiopathiae&amp;lt;/i&amp;gt; strains isolated from acute swine erysipelas outbreaks in Eastern China. ( 25649849 )
2015
50
Safety and efficacy of a new octavalent combined Erysipelas, Parvo and Leptospira vaccine in gilts against Leptospira interrogans serovar Pomona associated disease and foetal death. ( 26100922 )
2015

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CAT ELANE SOD1 TNF
2 extracellular region GO:0005576 9.1 CALCA CAT ELANE PI3 SOD1 TNF

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 ELANE TNF
2 response to hydrogen peroxide GO:0042542 9.57 CAT SOD1
3 antimicrobial humoral response GO:0019730 9.56 ELANE PI3
4 response to heat GO:0009408 9.55 CALCA SOD1
5 response to UV GO:0009411 9.54 CAT ELANE
6 interleukin-12-mediated signaling pathway GO:0035722 9.52 SOD1 SOD2
7 embryo implantation GO:0007566 9.51 CALCA SOD1
8 positive regulation of cytokine production GO:0001819 9.49 SOD1 TNF
9 positive regulation of interleukin-8 production GO:0032757 9.48 CALCA TNF
10 superoxide metabolic process GO:0006801 9.46 SOD1 SOD2
11 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE TNF
12 cellular response to oxidative stress GO:0034599 9.43 CAT SOD1 SOD2
13 removal of superoxide radicals GO:0019430 9.4 SOD1 SOD2
14 response to reactive oxygen species GO:0000302 9.37 CAT SOD1
15 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.32 ELANE TNF
16 response to superoxide GO:0000303 9.16 SOD1 SOD2
17 regulation of blood pressure GO:0008217 9.13 CALCA SOD1 SOD2
18 aging GO:0007568 8.92 CALCA CAT SOD1 SOD2

Molecular functions related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 9.16 CAT SOD1
2 identical protein binding GO:0042802 9.1 CALCA CAT MEFV SOD1 SOD2 TNF
3 superoxide dismutase activity GO:0004784 8.96 SOD1 SOD2

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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