MCID: ERY004
MIFTS: 46

Erysipelas

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 77 54 30 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD9CM 36 035
MeSH 45 D004886
SNOMED-CT 69 44653001
ICD10 34 A46
UMLS 74 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to familial mediterranean fever and pneumonia, and has symptoms including exanthema An important gene associated with Erysipelas is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Longevity regulating pathway and DNA Damage Response (only ATM dependent). The drugs Penicillin V and Daptomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia : 77 Erysipelas is an acute infection typically with a skin rash, usually on any of the legs and toes, face,... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 familial mediterranean fever 30.0 MEFV TNF
2 pneumonia 29.9 ELANE PIK3C2A TNF
3 vasculitis 29.9 ELANE MEFV TNF
4 pyoderma gangrenosum 29.7 MEFV TNF
5 pyoderma 29.7 MEFV TNF
6 pleurisy 29.6 MEFV TNF
7 skin disease 29.5 CAT PI3 TNF
8 impetigo 29.5 CALCA ELANE PI3
9 endocarditis 29.5 PIK3C2A TNF
10 cellulitis 10.6
11 arthritis 10.4
12 arthus reaction 10.3 ELANE TNF
13 periodontosis 10.3 ELANE TNF
14 pustulosis palmaris et plantaris 10.3 ELANE TNF
15 lymphedema 10.2
16 type 1 diabetes mellitus 10 10.2 CAT SOD2
17 cardiogenic shock 10.2 PIK3C2A TNF
18 anthracosis 10.2 SOD1 TNF
19 diabetic angiopathy 10.2 CAT SOD2
20 adult respiratory distress syndrome 10.2 ELANE TNF
21 complex regional pain syndrome 10.2 CALCA TNF
22 meningitis and encephalitis 10.2 CAT SOD1
23 crimean-congo hemorrhagic fever 10.2 PIK3C2A TNF
24 status asthmaticus 10.2 ELANE PIK3C2A
25 compartment syndrome 10.2 PIK3C2A TNF
26 eales disease 10.2 SOD1 TNF
27 japanese encephalitis 10.2 SOD1 TNF
28 myocardial stunning 10.2 CAT SOD1
29 thrombosis 10.2
30 irritant dermatitis 10.2 PI3 TNF
31 extrinsic cardiomyopathy 10.2 PIK3C2A TNF
32 bacterial pneumonia 10.2 CALCA ELANE
33 impetigo herpetiformis 10.2 ELANE PI3
34 leptospirosis 10.2 PIK3C2A TNF
35 chorioamnionitis 10.1 ELANE TNF
36 bronchopneumonia 10.1 ELANE PI3
37 erysipeloid 10.1
38 bronchopulmonary dysplasia 10.1 ELANE SOD1
39 legionellosis 10.1 PIK3C2A TNF
40 gingivitis 10.1 ELANE TNF
41 tonsillitis 10.1 SOD1 TNF
42 breast cancer 10.1
43 diphtheria 10.1
44 scarlet fever 10.1
45 fasciitis 10.1
46 toxic myocarditis 10.1 PIK3C2A SOD1
47 glycogen storage disease iii 10.1 CALCA PIK3C2A
48 engraftment syndrome 10.1 CALCA PI3
49 netherton syndrome 10.1 ELANE PI3
50 pulmonary edema 10.1 PIK3C2A TNF

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

MGI Mouse Phenotypes related to Erysipelas:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 CAT ELANE MEFV PIK3C2A SOD1 SOD2
2 neoplasm MP:0002006 9.02 CAT ELANE SOD1 SOD2 TNF

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
3
Vancomycin Approved Phase 4 1404-90-6 441141 14969
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5 Anti-Bacterial Agents Phase 4,Phase 2
6 Anti-Infective Agents Phase 4,Phase 2
7 Antibiotics, Antitubercular Phase 4
8 penicillins Phase 4
9 Antitubercular Agents Phase 4
10 Floxacillin Phase 4
11
Tedizolid Approved, Investigational Phase 2 856866-72-3
12
Tedizolid phosphate Approved Phase 2 856867-55-5
13
leucovorin Approved Phase 2 58-05-9 6006 143
14
Trimethoprim Approved, Vet_approved Phase 2 738-70-5 5578
15
Sulfamethoxazole Approved Phase 2 723-46-6 5329
16
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
18 Folic Acid Antagonists Phase 2
19 Antiprotozoal Agents Phase 2
20 Renal Agents Phase 2
21 Anti-Infective Agents, Urinary Phase 2
22 Antiparasitic Agents Phase 2
23 Vitamin B9 Phase 2
24 Folate Phase 2
25 Cytochrome P-450 Enzyme Inhibitors Phase 2
26 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
27 Vitamin B Complex Phase 2
28 Antimalarials Phase 2
29
Dimenhydrinate Approved Not Applicable 523-87-5 441281
30
Linezolid Approved, Investigational 165800-03-3 441401
31 Dermatologic Agents Not Applicable
32 methicillin

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
2 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Short Course of Amoxicillin for Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
4 Duration of ANtibiotic Therapy for CEllulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
5 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
6 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Unknown status NCT02981485 Phase 2
7 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study Completed NCT01519778 Phase 2 TR701 FA
8 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
9 Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections Completed NCT02052388 Phase 2 Daptomycin;Brilacidin
10 Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment Not yet recruiting NCT03637400 Phase 2 TMP-SMX;DOXY
11 The Use of Oral Steroids in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
12 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
13 Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Recruiting NCT02609724 Not Applicable
14 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable
15 Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Terminated NCT02991131 Tedizolid (Sivextro, BAY 11-70438);Linezolid
16 The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever. Withdrawn NCT02021084 Not Applicable

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 30

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

42
Skin, Testes, Breast, Colon, Bone, Lymph Node, Eye

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 668)
# Title Authors Year
1
Adherence to antibiotic guidelines for erysipelas or cellulitis is associated with a favorable outcome. ( 30685804 )
2019
2
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. ( 30563611 )
2019
3
Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence. ( 30761303 )
2019
4
Erysipelas carcinomatosum. ( 30782312 )
2019
5
Dacryocystitis mimicking erysipelas due to a giant dacryolith. ( 29655289 )
2018
6
<i>Erysipelothrix rhusiopathiae</i> serotype 15 associated with recurring pig erysipelas outbreaks. ( 29519854 )
2018
7
Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas. ( 29578137 )
2018
8
Trends in the epidemiology of erysipelas in Slovenia. ( 29589637 )
2018
9
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
10
Recurrent erysipelas of the face with hyperimmune reaction to group C streptococcus. ( 29526042 )
2018
11
Corticosteroid Therapy in Combination with Antibiotics for Erysipelas. ( 29527848 )
2018
12
INDEXES OF CYTOKINE PROFILE OF BLOOD IN PATIENTS WITH COMPLICATED ERYSIPELAS. ( 29461220 )
2018
13
Erysipelas or cellulitis with a prosthetic joint in situ. ( 30416947 )
2018
14
Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis. ( 30535927 )
2018
15
Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice. ( 29992162 )
2018
16
A Case of Recurrent Erysipelas Caused by Streptococcus mitis Group. ( 30018832 )
2018
17
Facial Erysipelas After Secukinumab Therapy. ( 30139691 )
2018
18
Milian's ear sign: Erysipelas. ( 30191132 )
2018
19
Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs. ( 30210067 )
2018
20
Management of necrotizing and non-necrotic bacterial erysipelas of the face in tropical areas: a series of four cases and a review of the literature. ( 30270829 )
2018
21
A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas. ( 30519119 )
2018
22
Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. ( 28314730 )
2017
23
Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. ( 28477399 )
2017
24
Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease. ( 28741584 )
2017
25
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan. ( 27773881 )
2017
26
Interventions for the prevention of recurrent erysipelas and cellulitis. ( 28631307 )
2017
27
Benzathine penicillin G once-every-3-week prophylaxis for recurrent erysipelas a retrospective study of 132 patients. ( 28489486 )
2017
28
Single nucleotide polymorphism genotyping of Erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in Japan. ( 28250289 )
2017
29
Bilateral Milian's Ear Sign of Erysipelas. ( 28794379 )
2017
30
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
31
Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients. ( 28512644 )
2017
32
Risk factors associated with local complications of erysipelas: a retrospective study of 152 cases. ( 28451043 )
2017
33
The Myth of Erysipelas-Fire, Water, and Blood. ( 28114522 )
2017
34
Familial Mediterranean fever patients may have unmet need for treatment of erysipelas-like erythema. ( 27782864 )
2016
35
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
36
Complete genome sequence of Erysipelothrix rhusiopathiae strain GXBY-1 isolated from acute swine erysipelas outbreaks in south China. ( 27222802 )
2016
37
A Fatal Case of &amp;quot;Bullous Erysipelas-like&amp;quot; Pseudomonas Vasculitis. ( 26955132 )
2016
38
Complicated Skin and Skin Structure Infection After Erysipelas: Urgent Need for Antibiosis and Surgery. ( 26933116 )
2016
39
Clinical and epidemiological assessment of patients hospitalized for primary and recurrent erysipelas ( 28221013 )
2016
40
The effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on swine humoral immune response induced by erysipelas vaccination. ( 27072375 )
2016
41
High Incidence of Erysipelas After Surgical Treatment for Vulvar Carcinoma: An Observational Study. ( 26807636 )
2016
42
Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection. ( 26791960 )
2016
43
How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review. ( 27765000 )
2016
44
Low sensitivity of needle aspiration cultures in patients with cellulitis/erysipelas. ( 27652151 )
2016
45
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
46
Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas. ( 27085865 )
2016
47
Liposuction of Postmastectomy Arm Lymphedema Decreases the Incidence of Erysipelas. ( 29906366 )
2016
48
Erysipelas, a large retrospective study of aetiology and clinical presentation. ( 26424182 )
2015
49
Risk factors associated with a reduced response in the treatment of erysipelas. ( 25706926 )
2015
50
Erysipelas in turkeys, sheep and pigs. ( 25792678 )
2015

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CAT ELANE SOD1 TNF
2 extracellular region GO:0005576 9.1 CALCA CAT ELANE PI3 SOD1 TNF

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 ELANE TNF
2 response to hydrogen peroxide GO:0042542 9.57 CAT SOD1
3 antimicrobial humoral response GO:0019730 9.56 ELANE PI3
4 response to heat GO:0009408 9.55 CALCA SOD1
5 response to UV GO:0009411 9.54 CAT ELANE
6 interleukin-12-mediated signaling pathway GO:0035722 9.52 SOD1 SOD2
7 embryo implantation GO:0007566 9.51 CALCA SOD1
8 positive regulation of cytokine production GO:0001819 9.49 SOD1 TNF
9 positive regulation of interleukin-8 production GO:0032757 9.48 CALCA TNF
10 superoxide metabolic process GO:0006801 9.46 SOD1 SOD2
11 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE TNF
12 cellular response to oxidative stress GO:0034599 9.43 CAT SOD1 SOD2
13 removal of superoxide radicals GO:0019430 9.4 SOD1 SOD2
14 response to reactive oxygen species GO:0000302 9.37 CAT SOD1
15 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.32 ELANE TNF
16 response to superoxide GO:0000303 9.16 SOD1 SOD2
17 regulation of blood pressure GO:0008217 9.13 CALCA SOD1 SOD2
18 aging GO:0007568 8.92 CALCA CAT SOD1 SOD2

Molecular functions related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 9.16 CAT SOD1
2 identical protein binding GO:0042802 9.1 CALCA CAT MEFV SOD1 SOD2 TNF
3 superoxide dismutase activity GO:0004784 8.96 SOD1 SOD2

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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