MCID: ERY004
MIFTS: 44

Erysipelas

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 77 54 30 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD9CM 36 035
MeSH 45 D004886
SNOMED-CT 69 44653001
ICD10 34 A46
UMLS 74 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to elephantiasis and familial mediterranean fever, and has symptoms including exanthema An important gene associated with Erysipelas is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Selenium Micronutrient Network and Detoxification of Reactive Oxygen Species. The drugs Penicillin V and Daptomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast.

Wikipedia : 77 Erysipelas is an acute infection typically with a skin rash, usually on any of the legs and toes, face,... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 elephantiasis 30.4 ELANE ELN
2 familial mediterranean fever 30.0 MEFV TNF
3 pneumonia 29.9 ELANE PIK3C2A TNF
4 vasculitis 29.9 ELANE MEFV TNF
5 pyoderma gangrenosum 29.7 MEFV TNF
6 pyoderma 29.7 MEFV TNF
7 pleurisy 29.6 MEFV TNF
8 endocarditis 29.6 PIK3C2A TNF
9 cellulitis 10.6
10 arthritis 10.4
11 arthus reaction 10.3 ELANE TNF
12 periodontosis 10.3 ELANE TNF
13 pustulosis palmaris et plantaris 10.3 ELANE TNF
14 anthracosis 10.3 SOD1 TNF
15 complex regional pain syndrome 10.3 CALCA TNF
16 eales disease 10.2 SOD1 TNF
17 lymphedema 10.2
18 japanese encephalitis 10.2 SOD1 TNF
19 cardiogenic shock 10.2 PIK3C2A TNF
20 retinal ischemia 10.2 SOD1 TNF
21 cerebral aneurysms 10.2 ELANE ELN
22 mid-dermal elastolysis 10.2 ELANE ELN
23 crimean-congo hemorrhagic fever 10.2 PIK3C2A TNF
24 compartment syndrome 10.2 PIK3C2A TNF
25 status asthmaticus 10.2 ELANE PIK3C2A
26 bronchopulmonary dysplasia 10.2 ELANE SOD1
27 bacterial pneumonia 10.2 CALCA ELANE
28 thrombosis 10.2
29 extrinsic cardiomyopathy 10.2 PIK3C2A TNF
30 chorioamnionitis 10.2 ELANE TNF
31 irritant dermatitis 10.2 PI3 TNF
32 leptospirosis 10.2 PIK3C2A TNF
33 tonsillitis 10.2 SOD1 TNF
34 alpha-1-antitrypsin deficiency 10.2 ELANE ELN
35 erysipeloid 10.2
36 impetigo herpetiformis 10.2 ELANE PI3
37 gingivitis 10.2 ELANE TNF
38 bronchopneumonia 10.1 ELANE PI3
39 pneumoconiosis 10.1 SOD1 TNF
40 legionellosis 10.1 PIK3C2A TNF
41 toxic myocarditis 10.1 PIK3C2A SOD1
42 aortic aneurysm, familial abdominal, 1 10.1 ELANE ELN
43 glycogen storage disease iii 10.1 CALCA PIK3C2A
44 engraftment syndrome 10.1 CALCA PI3
45 pulmonary emphysema 10.1 ELANE ELN
46 breast cancer 10.1
47 diphtheria 10.1
48 scarlet fever 10.1
49 fasciitis 10.1
50 bacterial sepsis 10.1 CALCA ELANE TNF

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
3
Vancomycin Approved Phase 4 1404-90-6 14969 441141
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5 Antibiotics, Antitubercular Phase 4
6 Anti-Infective Agents Phase 4,Phase 2
7 Anti-Bacterial Agents Phase 4,Phase 2
8 penicillins Phase 4
9 Antitubercular Agents Phase 4
10 Floxacillin Phase 4
11
Tedizolid phosphate Approved Phase 2 856867-55-5
12
Tedizolid Approved, Investigational Phase 2 856866-72-3
13
leucovorin Approved Phase 2 58-05-9 143 6006
14
Sulfamethoxazole Approved Phase 2 723-46-6 5329
15
Trimethoprim Approved, Vet_approved Phase 2 738-70-5 5578
16
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
18 Anti-Infective Agents, Urinary Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 2
20 Antiprotozoal Agents Phase 2
21 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
22 Vitamin B9 Phase 2
23 Antiparasitic Agents Phase 2
24 Renal Agents Phase 2
25 Antimalarials Phase 2
26 Vitamin B Complex Phase 2
27 Folic Acid Antagonists Phase 2
28 Folate Phase 2
29
Dimenhydrinate Approved Not Applicable 523-87-5 441281
30
Linezolid Approved, Investigational 165800-03-3 441401
31 Dermatologic Agents Not Applicable
32 methicillin

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
2 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Short Course of Amoxicillin for Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
4 Duration of ANtibiotic Therapy for CEllulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
5 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
6 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Unknown status NCT02981485 Phase 2
7 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study Completed NCT01519778 Phase 2 TR701 FA
8 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
9 Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections Completed NCT02052388 Phase 2 Daptomycin;Brilacidin
10 Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment Not yet recruiting NCT03637400 Phase 2 TMP-SMX;DOXY
11 The Use of Oral Steroids in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
12 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Completed NCT02902822 Not Applicable
13 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
14 Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Recruiting NCT02609724 Not Applicable
15 Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever Not yet recruiting NCT03917277 Not Applicable
16 Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Terminated NCT02991131 Tedizolid (Sivextro, BAY 11-70438);Linezolid
17 The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever. Withdrawn NCT02021084 Not Applicable

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 30

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

42
Skin, Testes, Breast, Thyroid, Lung, Colon, B Cells

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 670)
# Title Authors Year
1
Frequent colonization of betahaemolytic streptococci at various body sites including the perineum and anal canal during erysipelas and cellulitis. ( 31088328 )
2019
2
Adherence to antibiotic guidelines for erysipelas or cellulitis is associated with a favorable outcome. ( 30685804 )
2019
3
Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis. ( 30535927 )
2019
4
Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence. ( 30761303 )
2019
5
Erysipelas carcinomatosum. ( 30782312 )
2019
6
Clinical Presentation and Laboratory Characteristics in Acute and Recurrent Erysipelas. ( 30962836 )
2019
7
Comorbidities as Risk Factors for Acute and Recurrent Erysipelas. ( 30976336 )
2019
8
Erysipelas or cellulitis with a prosthetic joint in situ. ( 30416947 )
2018
9
Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas. ( 29578137 )
2018
10
Benzathine penicillin G once-every-3-week prophylaxis for recurrent erysipelas a retrospective study of 132 patients. ( 28489486 )
2018
11
INDEXES OF CYTOKINE PROFILE OF BLOOD IN PATIENTS WITH COMPLICATED ERYSIPELAS. ( 29461220 )
2018
12
Erysipelothrix rhusiopathiae serotype 15 associated with recurring pig erysipelas outbreaks. ( 29519854 )
2018
13
Dacryocystitis mimicking erysipelas due to a giant dacryolith. ( 29655289 )
2018
14
Recurrent erysipelas of the face with hyperimmune reaction to group C streptococcus. ( 29526042 )
2018
15
Corticosteroid Therapy in Combination with Antibiotics for Erysipelas. ( 29527848 )
2018
16
Trends in the epidemiology of erysipelas in Slovenia. ( 29589637 )
2018
17
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
18
Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice. ( 29992162 )
2018
19
A Case of Recurrent Erysipelas Caused by Streptococcus mitis Group. ( 30018832 )
2018
20
Facial Erysipelas After Secukinumab Therapy. ( 30139691 )
2018
21
Milian's ear sign: Erysipelas. ( 30191132 )
2018
22
Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs. ( 30210067 )
2018
23
Management of necrotizing and non-necrotic bacterial erysipelas of the face in tropical areas: a series of four cases and a review of the literature. ( 30270829 )
2018
24
A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas. ( 30519119 )
2018
25
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. ( 30563611 )
2018
26
Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. ( 28477399 )
2017
27
Interventions for the prevention of recurrent erysipelas and cellulitis. ( 28631307 )
2017
28
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
29
Erysipelas as an aggravating factor for impaired lymphatics in saphenectomy patients. ( 26344512 )
2017
30
How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review. ( 27765000 )
2017
31
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan. ( 27773881 )
2017
32
Familial Mediterranean fever patients may have unmet needs for treatment of erysipelas-like erythema. ( 27782864 )
2017
33
The Myth of Erysipelas-Fire, Water, and Blood. ( 28114522 )
2017
34
Single nucleotide polymorphism genotyping of Erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in Japan. ( 28250289 )
2017
35
Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. ( 28314730 )
2017
36
Risk factors associated with local complications of erysipelas: a retrospective study of 152 cases. ( 28451043 )
2017
37
Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients. ( 28512644 )
2017
38
Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease. ( 28741584 )
2017
39
Bilateral Milian's Ear Sign of Erysipelas. ( 28794379 )
2017
40
Low sensitivity of needle aspiration cultures in patients with cellulitis/erysipelas. ( 27652151 )
2016
41
Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection. ( 26791960 )
2016
42
High Incidence of Erysipelas After Surgical Treatment for Vulvar Carcinoma: An Observational Study. ( 26807636 )
2016
43
Complicated Skin and Skin Structure Infection After Erysipelas: Urgent Need for Antibiosis and Surgery. ( 26933116 )
2016
44
A Fatal Case of "Bullous Erysipelas-like" Pseudomonas Vasculitis. ( 26955132 )
2016
45
Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination. ( 27072375 )
2016
46
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
47
Complete genome sequence of Erysipelothrix rhusiopathiae strain GXBY-1 isolated from acute swine erysipelas outbreaks in south China. ( 27222802 )
2016
48
Clinical and epidemiological assessment of patients hospitalized for primary and recurrent erysipelas ( 28221013 )
2016
49
Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas. ( 27085865 )
2016
50
Liposuction of Postmastectomy Arm Lymphedema Decreases the Incidence of Erysipelas. ( 29906366 )
2016

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CALCA ELANE ELN PI3 SOD1 TNF
2 extracellular matrix GO:0031012 8.96 ELN PI3

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.55 ELANE TNF
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.54 ELANE TNF
3 antimicrobial humoral response GO:0019730 9.52 ELANE PI3
4 interleukin-12-mediated signaling pathway GO:0035722 9.49 SOD1 SOD2
5 embryo implantation GO:0007566 9.48 CALCA SOD1
6 positive regulation of cytokine production GO:0001819 9.46 SOD1 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.43 CALCA TNF
8 superoxide metabolic process GO:0006801 9.37 SOD1 SOD2
9 negative regulation of growth of symbiont in host GO:0044130 9.32 ELANE TNF
10 removal of superoxide radicals GO:0019430 9.26 SOD1 SOD2
11 response to heat GO:0009408 9.21 SOD1
12 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 ELANE TNF
13 aging GO:0007568 9.1 SOD1
14 response to superoxide GO:0000303 8.96 SOD1 SOD2
15 regulation of blood pressure GO:0008217 8.8 CALCA SOD1 SOD2

Molecular functions related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 CALCA MEFV SOD1 SOD2 TNF
2 superoxide dismutase activity GO:0004784 8.62 SOD1 SOD2

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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