MCID: ERY017
MIFTS: 36

Erythema Elevatum Diutinum

Categories: Bone diseases, Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erythema Elevatum Diutinum

MalaCards integrated aliases for Erythema Elevatum Diutinum:

Name: Erythema Elevatum Diutinum 12 20 58 44 15 70 32

Characteristics:

Orphanet epidemiological data:

58
erythema elevatum diutinum
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:0060567
MeSH 44 C535509
SNOMED-CT 67 201300002
ICD10 32 L95.1
MESH via Orphanet 45 C535509
ICD10 via Orphanet 33 L95.1
UMLS via Orphanet 71 C0263398
Orphanet 58 ORPHA90000
UMLS 70 C0263398

Summaries for Erythema Elevatum Diutinum

GARD : 20 Erythema elevatum diutinum (EED) is a disorder of the skin associated with small blood vessel inflammation ( vasculitis ). Symptoms include red, purple, brown or yellow bumps of different sizes that grow on or just below the skin. These growths are located mainly on the elbows, knees, ankles, hands, and fingers. People with EED may also have joint pain, but few other symptoms. EED symptoms begin in adulthood and can last for many years. Many cases get better on their own, but this may take many years. The cause of EED is unknown. Diagnosis is made based on the symptoms and a skin biopsy to look at the skin growths. Treatment includes antibiotics and other medications.

MalaCards based summary : Erythema Elevatum Diutinum is related to pyoderma and granuloma annulare. An important gene associated with Erythema Elevatum Diutinum is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways is Malaria. Affiliated tissues include skin, breast and heart, and related phenotypes are arthralgia and skin rash

Disease Ontology : 12 A vasculitis characterised by red, purple, brown or yellow papules (raised spot), plaques, or nodules, found on the backs of the hands, other extensor surfaces overlying joints, and on the buttocks.

Wikipedia : 73 Erythema elevatum diutinum is a form of... more...

Related Diseases for Erythema Elevatum Diutinum

Diseases related to Erythema Elevatum Diutinum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 pyoderma 31.0 PSTPIP1 CXCL8
2 granuloma annulare 30.9 F13A1 CD1E
3 pyoderma gangrenosum 30.9 PSTPIP1 CXCL8
4 keratitis, hereditary 30.8 PECAM1 CXCL8 CD1E
5 neutrophilic dermatosis, acute febrile 30.6 PSTPIP1 CXCL8
6 fasciitis 30.5 CXCL8 CD34
7 bacillary angiomatosis 30.5 PECAM1 CD34
8 pseudosarcomatous fibromatosis 30.4 PECAM1 CD34
9 cutaneous fibrous histiocytoma 30.4 F13A1 CD34
10 fibroma 30.2 S100A9 PECAM1 F13A1 CD34
11 inflammatory bowel disease 29.7 S100A9 PSTPIP1 PECAM1 CXCL8
12 vascular disease 29.7 PECAM1 F13A1 CD34
13 vasculitis 11.1
14 skin disease 10.7
15 immune deficiency disease 10.6
16 myelodysplastic syndrome 10.6
17 kaposi sarcoma 10.5
18 dermatitis herpetiformis, familial 10.5
19 dermatitis herpetiformis 10.5
20 hepatitis b 10.4
21 dermatitis 10.4
22 necrobiosis lipoidica 10.4
23 crohn's disease 10.4
24 autoimmune disease 10.3
25 systemic lupus erythematosus 10.3
26 celiac disease 1 10.3
27 myeloma, multiple 10.3
28 cutaneous lupus erythematosus 10.3
29 exanthem 10.3
30 bacterial infectious disease 10.3
31 scleritis 10.3
32 hepatitis 10.3
33 relapsing polychondritis 10.3
34 acquired immunodeficiency syndrome 10.3
35 connective tissue disease 10.3
36 lupus erythematosus 10.3
37 hypereosinophilic syndrome 10.3
38 acroosteolysis 10.2
39 spondyloarthropathy 1 10.2
40 leukemia, chronic lymphocytic 10.2
41 pityriasis rubra pilaris 10.2
42 porphyria cutanea tarda 10.2
43 rheumatoid arthritis 10.2
44 familial mediterranean fever 10.2
45 myasthenia gravis 10.2
46 myxedema 10.2
47 hypereosinophilic syndrome, idiopathic 10.2
48 dermatofibrosarcoma protuberans 10.2
49 leukemia, chronic myeloid 10.2
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2

Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to Erythema Elevatum Diutinum

Symptoms & Phenotypes for Erythema Elevatum Diutinum

Human phenotypes related to Erythema Elevatum Diutinum:

58 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
3 vasculitis in the skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0200029
4 skin vesicle 58 31 frequent (33%) Frequent (79-30%) HP:0200037
5 abnormal blistering of the skin 58 31 frequent (33%) Frequent (79-30%) HP:0008066
6 increased circulating antibody level 31 frequent (33%) HP:0010702
7 myalgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003326
8 skin nodule 58 31 occasional (7.5%) Occasional (29-5%) HP:0200036
9 increased antibody level in blood 58 Frequent (79-30%)

Drugs & Therapeutics for Erythema Elevatum Diutinum

Search Clinical Trials , NIH Clinical Center for Erythema Elevatum Diutinum

Cochrane evidence based reviews: erythema elevatum diutinum

Genetic Tests for Erythema Elevatum Diutinum

Anatomical Context for Erythema Elevatum Diutinum

MalaCards organs/tissues related to Erythema Elevatum Diutinum:

40
Skin, Breast, Heart, Thyroid, Neutrophil, Bone, Spleen

Publications for Erythema Elevatum Diutinum

Articles related to Erythema Elevatum Diutinum:

(show top 50) (show all 338)
# Title Authors PMID Year
1
The role of IL-8 in skin lesions of a patient with erythema elevatum diutinum. 61
33604932 2021
2
A rare presentation of erythema elevatum diutinum with annular lesions on the trunk. 61
33219580 2021
3
Chronic Fibrosing Vasculitis: A Histologic Finding in a Case of Long-Established Erythema Elevatum Diutinum. 61
33307006 2020
4
Maculopapular eruptions associated to COVID-19: A subanalysis of the COVID-Piel study. 61
32779280 2020
5
Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage. 61
31663600 2020
6
Erythema elevatum diutinum: an unusual cutaneous vasculitis associated with rheumatoid arthritis. 61
32294207 2020
7
Exuberant case of erythema elevatum diutinum in a patient infected with HIV and hepatitis B virus. 61
32173140 2020
8
Bullous Erythema Elevatum Diutinum Associated with Immunoglobulin a Monoclonal Gammopathy: An Atypical Variant. 61
32180612 2020
9
Erythema elevatum diutinum of the hand: a peculiar case, successfully treated with tetracyclines. 61
32129588 2020
10
Atypical Palmar Involvement with Erythema Elevatum Diutinum as a Sole Manifestation: A Report of Two Cases. 61
32821145 2020
11
Concurrence of erythema elevatum diutinum and HIV infection: A case report and literature review. 61
31828194 2019
12
Unusual presentation of erythema elevatum diutinum in an HIV-positive man with dramatic response to dapsone. 61
31726928 2019
13
Erythema Elevatum Diutinum - Two Case Reports, Two Different Clinical Presentations, and a Short Literature Review. 61
31850118 2019
14
Erythema Elevatum Diutinum Treated With Mycophenolate Mofetil. 61
29509562 2019
15
The late stage of erythema elevatum diutinum mimicking cutaneous spindle-cell neoplasms: a case report and review of the literature. 61
31568579 2019
16
Primary Surgical Treatment of Erythema Elevatum Diutinum. 61
30241974 2019
17
Erythema elevatum diutinum: a case report and review of literature. 61
30074624 2019
18
Erythema elevatum diutinum a rare and poorly understood cutaneous vasculitis: A single institution experience. 61
30362150 2019
19
[Erratum to: Monolocular erythema elevatum diutinum on the back of the hand]. 61
30270407 2018
20
[Monolocular erythema elevatum diutinum on the back of the hand]. 61
30264321 2018
21
Rare presentation of erythema elevatum diutinum. 61
30238047 2018
22
Erythema elevatum diutinum. 61
30066783 2018
23
Erythema elevatum diutinum. 61
33288067 2018
24
Erythema elevatum diutinum-like vasculitis secondary to cocaine adulterated with levamisole. 61
29423942 2018
25
Unusual presentation of erythema elevatum diutinum with underlying hepatitis B infection. 61
30063775 2018
26
Late-Stage Erythema Elevatum Diutinum Mimicking a Fibroblastic Tumor: A Potential Pitfall. 61
29293121 2018
27
HIV-associated erythema elevatum diutinum: a case report and review of a clinically distinct variant. 61
30142732 2018
28
Erythema elevatum diutinum verbunden mit schwerer oropharyngealer Ulzeration und Pyoderma gangraenosum. 61
29750450 2018
29
Erythema elevatum diutinum associated with severe oropharyngeal ulceration and pyoderma gangrenosum. 61
29750453 2018
30
Neutrophilic dermatoses: a broad spectrum of disease. 61
29368857 2018
31
Pyoderma gangrenosum and erythema elevatum diutinum associated with a high-risk myelodysplastic syndrome: case report. 61
30057994 2018
32
Erythema elevatum diutinum with pustule formation: An unusual finding. 61
29292528 2018
33
Late-stage nodular erythema elevatum diutinum mimicking sclerotic fibroma. 61
29068068 2018
34
Truncal Erythema Elevatum Diutinum With Elevated Cryoglobulin Level. 61
29901001 2017
35
Erythema elevatum diutinum in Crohn's disease-associated Spondyloarthritis - a rare vasculitis, an unusual association. 61
28917218 2017
36
Complete resolution of erythema elevatum diutinum using oral sulfasalazine. 61
29469798 2017
37
Vesiculobullous variant of erythema elevatum diutinum. 61
28639709 2017
38
Erythema elevatum diutinum presenting with palmoplantar keratoderma. 61
28512994 2017
39
Erythema elevatum diutinum in a healthy child. 61
28397292 2017
40
Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum. 61
27930381 2017
41
Erythema elevatum diutinum-associated with loss of the uvula. 61
28443312 2017
42
Erythema Elevatum Diutinum. 61
28183422 2017
43
Erythema elevatum diutinum involving palms and soles: a case report and literature review. 61
28469800 2017
44
A rare case of erythema elevatum diutinum presenting as diffuse neuropathy. 61
28050587 2017
45
Approach to cutaneous vasculitides with special emphasis on small vessel vasculitis: histopathology and direct immunofluorescence. 61
27787337 2017
46
Pediatric case of microscopic polyangiitis with skin manifestations resembling vesiculobullous type erythema elevatum diutinum with immunoglobulin A antineutrophil cytoplasmic antibody. 61
27097593 2016
47
Erythema elevatum diutinum in association with IgA monoclonal gammopathy: A rare case report. 61
27559509 2016
48
Hidradenitis suppurativa (HS): An unrecognized paradoxical effect of biologic agents (BA) used in chronic inflammatory diseases. 61
26965410 2016
49
Neutrophilic Dermatoses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A French Multicenter Study of 17 Cases and Literature Review. 61
26986103 2016
50
Granuloma Faciale and Erythema Elevatum Diutinum in Relation to Immunoglobulin G4-Related Disease: An Appraisal of 32 Cases. 61
27124923 2016

Variations for Erythema Elevatum Diutinum

Expression for Erythema Elevatum Diutinum

Search GEO for disease gene expression data for Erythema Elevatum Diutinum.

Pathways for Erythema Elevatum Diutinum

Pathways related to Erythema Elevatum Diutinum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.32 PECAM1 CXCL8

GO Terms for Erythema Elevatum Diutinum

Biological processes related to Erythema Elevatum Diutinum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.16 S100A9 CXCL8
2 inflammatory response GO:0006954 9.13 S100A9 PSTPIP1 CXCL8
3 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Erythema Elevatum Diutinum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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