MCID: ERY002
MIFTS: 33

Erythema Infectiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Erythema Infectiosum

MalaCards integrated aliases for Erythema Infectiosum:

Name: Erythema Infectiosum 12 55 44 15 73
Fifth Disease 12 76 43 3

Classifications:



External Ids:

Disease Ontology 12 DOID:8743
ICD10 33 B08.3
ICD9CM 35 057.0
MeSH 44 D016731
NCIt 50 C84695
SNOMED-CT 68 34730008
UMLS 73 C0085273

Summaries for Erythema Infectiosum

MedlinePlus : 43 Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low fever, cold symptoms, and a headache. Then you get a red rash on your face. It looks like a "slapped cheek." The rash can spread to the arms, legs, and trunk. Adults who get it might also have joint pain and swelling. Fifth disease spreads easily, through saliva and mucus. You can get it when an infected person coughs or sneezes. Frequently washing your hands might help prevent getting the virus. Most people become immune to the virus after having it once. Fifth disease is usually mild and goes away on its own. However, it can be serious if you Are pregnant Are anemic Have cancer or a weak immune system Centers for Disease Control and Prevention

MalaCards based summary : Erythema Infectiosum, also known as fifth disease, is related to glomerulonephritis and parvovirus antenatal infection, and has symptoms including fever, pruritus and exanthema. An important gene associated with Erythema Infectiosum is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways is Malaria. The drugs Adjuvants, Immunologic and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and placenta, and related phenotype is homeostasis/metabolism.

CDC : 3 Parvovirus B19 infects only humans. It most commonly causes fifth disease, a mild rash illness that usually affects children. But it can cause different signs and symptoms, depending on your age and overall health. Many people infected with parvovirus B19 do not have any symptoms, or they have only mild, nonspecific rash illness, not unlike the common cold.

Wikipedia : 76 Erythema infectiosum or fifth disease is one of several possible manifestations of infection by... more...

Related Diseases for Erythema Infectiosum

Diseases related to Erythema Infectiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 29.9 CD40LG TLR9
2 parvovirus antenatal infection 11.8
3 myositis 10.2
4 ocular toxoplasmosis 10.1 CD40LG TLR9
5 toxoplasmosis 10.1 CD40LG TLR9
6 congenital toxoplasmosis 10.1 CD40LG TLR9
7 meningoencephalitis 10.1 CD40LG TLR9
8 b cell deficiency 10.1 CD40LG TLR9
9 immune deficiency disease 10.1 CD40LG TLR9
10 pfeiffer syndrome 10.1 CD40LG TLR9
11 systemic scleroderma 10.0 CD40LG TLR9
12 thrombocytopenic purpura, autoimmune 10.0
13 hydrops fetalis, nonimmune 10.0
14 hydrops fetalis, nonimmune, and/or atrial septal defect 10.0
15 acute lymphocytic leukemia 10.0
16 arthritis 10.0
17 hemolytic anemia 10.0
18 hepatitis 10.0
19 leukemia 10.0
20 lymphocytic leukemia 10.0
21 hemopericardium 10.0
22 pericardial effusion 10.0
23 aseptic meningitis 10.0
24 hereditary spherocytosis 10.0
25 purpura 10.0
26 arthropathy 10.0
27 rubella 10.0
28 meningitis 10.0
29 encephalitis 10.0
30 fetal edema 10.0
31 hydrops fetalis 10.0
32 encephalopathy 10.0
33 immune hydrops fetalis 10.0
34 pneumonia 10.0 CD40LG TLR9
35 viral infectious disease 10.0 CD40LG TLR9
36 catastrophic antiphospholipid syndrome 9.9 APOH CD40LG
37 antiphospholipid syndrome 9.9 APOH CD40LG
38 legg-calve-perthes disease 9.9 APOH CD40LG
39 syphilis 9.9 APOH CD40LG
40 placenta disease 9.9 APOH TLR9
41 vasculitis 9.9 APOH CD40LG
42 autoimmune disease 9.8 APOH CD40LG TLR9
43 autoimmune disease of musculoskeletal system 9.8 APOH CD40LG TLR9
44 immune system disease 9.8 APOH CD40LG TLR9
45 rheumatic disease 9.8 APOH CD40LG TLR9
46 connective tissue disease 9.8 APOH CD40LG TLR9
47 conjunctivitis 9.7
48 viral exanthem 9.2 APOH E2F6 FKTN PIN1 SLC45A2 TLR9

Graphical network of the top 20 diseases related to Erythema Infectiosum:



Diseases related to Erythema Infectiosum

Symptoms & Phenotypes for Erythema Infectiosum

UMLS symptoms related to Erythema Infectiosum:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Erythema Infectiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 APOH CD40LG FKTN PIN1 SLC45A2 TLR9

Drugs & Therapeutics for Erythema Infectiosum

Drugs for Erythema Infectiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adjuvants, Immunologic Phase 1, Phase 2
2 Immunologic Factors Phase 1, Phase 2
3 Vaccines Phase 1, Phase 2
4 MF59 oil emulsion Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 B-19 Parvovirus Vaccine Study Terminated NCT00379938 Phase 1, Phase 2 Placebo
2 A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease Completed NCT02261480

Search NIH Clinical Center for Erythema Infectiosum

Cochrane evidence based reviews: erythema infectiosum

Genetic Tests for Erythema Infectiosum

Anatomical Context for Erythema Infectiosum

MalaCards organs/tissues related to Erythema Infectiosum:

41
Skin, B Cells, Placenta

Publications for Erythema Infectiosum

Articles related to Erythema Infectiosum:

(show top 50) (show all 120)
# Title Authors Year
1
Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil. ( 27914222 )
2016
2
Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis. ( 24962467 )
2014
3
Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent. ( 24410941 )
2014
4
Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from 2000 to 2009. ( 24450250 )
2013
5
Acute glomerulonephritis in an immunocompetent elderly woman after contact with a child who had been diagnosed as erythema infectiosum. ( 22892503 )
2012
6
Erythema infectiosum rash. ( 21532111 )
2011
7
Erythema infectiosum: recognizing the many faces of fifth disease. ( 19601449 )
2009
8
Exposure to fifth disease in pregnancy. ( 20008596 )
2009
9
Prolonged parvovirus b19 viremia in spite of neutralizing antibodies after erythema infectiosum in pregnancy. ( 16940737 )
2007
10
Erythema infectiosum in children. A Clinical study. ( 17068883 )
2006
11
Erythema infectiosum following generalized petechial eruption induced by human parvovirus B19. ( 16608124 )
2006
12
Detection of parvovirus B19 in a case of erythema infectiosum with myositis. ( 17033121 )
2006
13
Erythema infectiosum. ( 16502203 )
2005
14
Incubation period for fifth disease. ( 15702058 )
2005
15
Parvovirus B19 infection: fifth disease and more. ( 15767606 )
2005
16
What you need to know about ... erythema infectiosum. ( 14768150 )
2004
17
Photo quiz. Erythema infectiosum. ( 10696555 )
2000
18
Slapped cheek is fifth disease: but what of the others? ( 11127184 )
2000
19
Erythema infectiosum (Fifth disease) and pregnancy. ( 10099795 )
1999
20
Fifth disease in a small rural community. What are the consequences? ( 10048252 )
1999
21
Neonatal erythema infectiosum. ( 9583210 )
1998
22
Human parvovirus B19--flushed in face though healthy (fifth disease and more). ( 9849265 )
1998
23
Index of suspicion. Case 1. Diagnosis: erythema infectiosum (EI). ( 8857202 )
1996
24
Fifth disease after immunoglobulin administration in an AIDS patient with parvovirus-induced red cell aplasia. ( 8686703 )
1996
25
Conjunctivitis associated with fifth disease in a child: a case report. ( 9286318 )
1996
26
Erythema infectiosum (fifth disease). ( 8559707 )
1995
27
A study by means of a new assay of the relationship between an outbreak of erythema infectiosum and non-immune hydrops fetalis caused by human parvovirus B19. ( 8586838 )
1995
28
What is your assessment? Erythema infectiosum. ( 7708465 )
1994
29
Persistent erythema infectiosum-like rash as a prodrome of acute lymphocytic leukemia. ( 8041657 )
1994
30
Erythema infectiosum and other parvovirus B19 infections. ( 8042568 )
1994
31
Case report: detection of parvovirus B19 in a skin biopsy of a patient with erythema infectiosum. ( 8083666 )
1994
32
Images in clinical medicine. Fifth disease. ( 8090166 )
1994
33
Acute polyarthritis. Fifth disease passed from child to adult. ( 8202421 )
1994
34
An outbreak of erythema infectiosum among hospital staff members including a patient with pleural fluid and pericardial effusion. ( 8335751 )
1993
35
Parvovirus B-19 infection: aplastic crisis, erythema infectiosum and idiopathic thrombocytopenic purpura. ( 1645857 )
1991
36
Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. ( 1765775 )
1991
37
Erythema infectiosum and pregnancy-related complications. ( 1846083 )
1991
38
Fifth disease and other parvovirus B19 infections. ( 1649150 )
1991
39
Erythema infectiosum ('fifth disease') exposure during pregnancy. ( 2157336 )
1990
40
Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. ( 2157074 )
1990
41
Erythema infectiosum and pregnancy-related complications. ( 2171743 )
1990
42
Erythema infectiosum--the fifth disease: case report. ( 2313450 )
1990
43
Aseptic meningitis with erythema infectiosum. ( 2158894 )
1990
44
American Academy of Pediatrics Committee on Infectious Diseases: Parvovirus, erythema infectiosum, and pregnancy. ( 2153280 )
1990
45
Prospective study of human parvovirus (B19) infection in pregnancy. Public Health Laboratory Service Working Party on Fifth Disease. ( 2161263 )
1990
46
Fifth disease: role for nurses in pediatric practice. ( 2163055 )
1990
47
Erythema infectiosum in a primary school: investigation of an outbreak in Bury. ( 2552489 )
1989
48
Erythema infectiosum (fifth disease). ( 2538215 )
1989
49
Fifth disease. A brief review of infections in childhood, in adulthood, and pregnancy. ( 2552948 )
1989
50
Fifth disease in children living in Belém, Brazil. ( 2560841 )
1989

Variations for Erythema Infectiosum

Expression for Erythema Infectiosum

Search GEO for disease gene expression data for Erythema Infectiosum.

Pathways for Erythema Infectiosum

Pathways related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.31 CD40LG TLR9

GO Terms for Erythema Infectiosum

Biological processes related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 8.96 CD40LG TLR9
2 positive regulation of interleukin-10 production GO:0032733 8.62 CD40LG TLR9

Sources for Erythema Infectiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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