MCID: ERY002
MIFTS: 33

Erythema Infectiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Erythema Infectiosum

Summaries for Erythema Infectiosum

MedlinePlus : 43 Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low fever, cold symptoms, and a headache. Then you get a red rash on your face. It looks like a "slapped cheek." The rash can spread to the arms, legs, and trunk. Adults who get it might also have joint pain and swelling. Fifth disease spreads easily, through saliva and mucus. You can get it when an infected person coughs or sneezes. Frequently washing your hands might help prevent getting the virus. Most people become immune to the virus after having it once. Fifth disease is usually mild and goes away on its own. However, it can be serious if you Are pregnant Are anemic Have cancer or a weak immune system Centers for Disease Control and Prevention

MalaCards based summary : Erythema Infectiosum, also known as fifth disease, is related to purpura and parvovirus antenatal infection, and has symptoms including exanthema, fever and pruritus. An important gene associated with Erythema Infectiosum is CD40LG (CD40 Ligand), and among its related pathways/superpathways is E2F transcription factor network. The drugs Adjuvants, Immunologic and MF59 oil emulsion have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are integument and reproductive system

CDC : 3 Parvovirus B19 infects only humans. It most commonly causes fifth disease, a mild rash illness that usually affects children. But it can cause different signs and symptoms, depending on your age and overall health. Many people infected with parvovirus B19 do not have any symptoms, or they have only mild, nonspecific rash illness, not unlike the common cold.

Wikipedia : 76 Erythema infectiosum or fifth disease is one of several possible manifestations of infection by... more...

Related Diseases for Erythema Infectiosum

Graphical network of the top 20 diseases related to Erythema Infectiosum:



Diseases related to Erythema Infectiosum

Symptoms & Phenotypes for Erythema Infectiosum

UMLS symptoms related to Erythema Infectiosum:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Erythema Infectiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 CD40LG E2F4 PIN1 SLC45A2
2 reproductive system MP:0005389 9.02 CD40LG E2F4 E2F6 PIN1 SLC45A2

Drugs & Therapeutics for Erythema Infectiosum

Drugs for Erythema Infectiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adjuvants, Immunologic Phase 1, Phase 2
2 MF59 oil emulsion Phase 1, Phase 2
3 Vaccines Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 B-19 Parvovirus Vaccine Study Terminated NCT00379938 Phase 1, Phase 2 Placebo
2 A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease Completed NCT02261480

Search NIH Clinical Center for Erythema Infectiosum

Cochrane evidence based reviews: erythema infectiosum

Genetic Tests for Erythema Infectiosum

Anatomical Context for Erythema Infectiosum

MalaCards organs/tissues related to Erythema Infectiosum:

41
Skin

Publications for Erythema Infectiosum

Articles related to Erythema Infectiosum:

(show top 50) (show all 94)
# Title Authors Year
1
Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil. ( 27914222 )
2016
2
Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis. ( 24962467 )
2014
3
Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent. ( 24410941 )
2014
4
Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from 2000 to 2009. ( 24450250 )
2013
5
Acute glomerulonephritis in an immunocompetent elderly woman after contact with a child who had been diagnosed as erythema infectiosum. ( 22892503 )
2012
6
Erythema infectiosum rash. ( 21532111 )
2011
7
Erythema infectiosum: recognizing the many faces of fifth disease. ( 19601449 )
2009
8
Prolonged parvovirus b19 viremia in spite of neutralizing antibodies after erythema infectiosum in pregnancy. ( 16940737 )
2007
9
Erythema infectiosum in children. A Clinical study. ( 17068883 )
2006
10
Erythema infectiosum following generalized petechial eruption induced by human parvovirus B19. ( 16608124 )
2006
11
Detection of parvovirus B19 in a case of erythema infectiosum with myositis. ( 17033121 )
2006
12
Erythema infectiosum. ( 16502203 )
2005
13
What you need to know about ... erythema infectiosum. ( 14768150 )
2004
14
Photo quiz. Erythema infectiosum. ( 10696555 )
2000
15
Erythema infectiosum (Fifth disease) and pregnancy. ( 10099795 )
1999
16
Neonatal erythema infectiosum. ( 9583210 )
1998
17
Index of suspicion. Case 1. Diagnosis: erythema infectiosum (EI). ( 8857202 )
1996
18
Erythema infectiosum (fifth disease). ( 8559707 )
1995
19
A study by means of a new assay of the relationship between an outbreak of erythema infectiosum and non-immune hydrops fetalis caused by human parvovirus B19. ( 8586838 )
1995
20
What is your assessment? Erythema infectiosum. ( 7708465 )
1994
21
Persistent erythema infectiosum-like rash as a prodrome of acute lymphocytic leukemia. ( 8041657 )
1994
22
Erythema infectiosum and other parvovirus B19 infections. ( 8042568 )
1994
23
Case report: detection of parvovirus B19 in a skin biopsy of a patient with erythema infectiosum. ( 8083666 )
1994
24
An outbreak of erythema infectiosum among hospital staff members including a patient with pleural fluid and pericardial effusion. ( 8335751 )
1993
25
Parvovirus B-19 infection: aplastic crisis, erythema infectiosum and idiopathic thrombocytopenic purpura. ( 1645857 )
1991
26
Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. ( 1765775 )
1991
27
Erythema infectiosum and pregnancy-related complications. ( 1846083 )
1991
28
Erythema infectiosum ('fifth disease') exposure during pregnancy. ( 2157336 )
1990
29
Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. ( 2157074 )
1990
30
Erythema infectiosum and pregnancy-related complications. ( 2171743 )
1990
31
Erythema infectiosum--the fifth disease: case report. ( 2313450 )
1990
32
American Academy of Pediatrics Committee on Infectious Diseases: Parvovirus, erythema infectiosum, and pregnancy. ( 2153280 )
1990
33
Erythema infectiosum in a primary school: investigation of an outbreak in Bury. ( 2552489 )
1989
34
Erythema infectiosum (fifth disease). ( 2538215 )
1989
35
Erythema infectiosum (fifth disease) occurrence in Iowa. ( 2841879 )
1988
36
Erythema infectiosum and parvovirus B19 infection in pregnancy. Infectious Diseases and Immunization Committee, Canadian Paediatric Society. ( 2843273 )
1988
37
Complications of erythema infectiosum in pregnancy. ( 2836015 )
1988
38
Erythema infectiosum during pregnancy. ( 2842412 )
1988
39
Erythema infectiosum. Slapped face disease. ( 2853623 )
1988
40
Pediatric management problems (erythema infectiosum). ( 3647348 )
1987
41
First picture of erythema infectiosum? ( 2880063 )
1987
42
An outbreak of 'slapped cheek' parvovirus infection (erythema infectiosum) in a Scottish street. ( 2820054 )
1987
43
Human parvovirus B19 arthropathy in two adults after contact with childhood erythema infectiosum. ( 2821807 )
1987
44
The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). ( 3016109 )
1986
45
Aplastic crisis and erythema infectiosum (fifth disease) revealing a hereditary spherocytosis in a familial human parvovirus infection. ( 3012459 )
1986
46
Erythema infectiosum in a village primary school: clinical and virological studies. ( 3761249 )
1986
47
Erythema infectiosum--a Bristol outbreak. ( 3995369 )
1985
48
An epidemic of erythema infectiosum in a school. ( 2999747 )
1985
49
Seasonal prevalence of erythema infectiosum. ( 3003175 )
1985
50
Human parvovirus (B19) and erythema infectiosum. ( 2989471 )
1985

Variations for Erythema Infectiosum

Expression for Erythema Infectiosum

Search GEO for disease gene expression data for Erythema Infectiosum.

Pathways for Erythema Infectiosum

Pathways related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 E2F4 E2F6

GO Terms for Erythema Infectiosum

Biological processes related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.13 E2F4 E2F6 PIN1
2 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 8.62 E2F4 E2F6

Sources for Erythema Infectiosum

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
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45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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