MCID: ERY002
MIFTS: 34

Erythema Infectiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Erythema Infectiosum

MalaCards integrated aliases for Erythema Infectiosum:

Name: Erythema Infectiosum 12 55 44 15 17 72
Fifth Disease 12 75 43 3

Classifications:



External Ids:

Disease Ontology 12 DOID:8743
ICD9CM 35 057.0
MeSH 44 D016731
NCIt 50 C84695
SNOMED-CT 68 34730008
ICD10 33 B08.3
UMLS 72 C0085273

Summaries for Erythema Infectiosum

MedlinePlus : 43 Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low fever, cold symptoms, and a headache. Then you get a red rash on your face. It looks like a "slapped cheek." The rash can spread to the arms, legs, and trunk. Adults who get it might also have joint pain and swelling. Fifth disease spreads easily, through saliva and mucus. You can get it when an infected person coughs or sneezes. Frequently washing your hands might help prevent getting the virus. Most people become immune to the virus after having it once. Fifth disease is usually mild and goes away on its own. However, it can be serious if you Are pregnant Are anemic Have cancer or a weak immune system Centers for Disease Control and Prevention

MalaCards based summary : Erythema Infectiosum, also known as fifth disease, is related to parvovirus antenatal infection and exanthem, and has symptoms including fever, pruritus and exanthema. An important gene associated with Erythema Infectiosum is CD40LG (CD40 Ligand). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are homeostasis/metabolism and vision/eye

CDC : 3 Parvovirus B19 infects only humans. It most commonly causes fifth disease, a mild rash illness that usually affects children. But it can cause different signs and symptoms, depending on your age and overall health. Many people infected with parvovirus B19 do not have any symptoms, or they have only mild, nonspecific rash illness, not unlike the common cold.

Wikipedia : 75 Erythema infectiosum or fifth disease is one of several possible manifestations of infection by... more...

Related Diseases for Erythema Infectiosum

Diseases related to Erythema Infectiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 parvovirus antenatal infection 11.5
2 exanthem 10.8
3 rubella 10.6
4 fetal edema 10.5
5 hydrops fetalis 10.5
6 purpura 10.4
7 arthropathy 10.4
8 hemolytic anemia 10.4
9 measles 10.4
10 myositis 10.3
11 aseptic meningitis 10.3
12 thrombocytopenia 10.3
13 neuritis 10.3
14 arthritis 10.3
15 meningitis 10.3
16 encephalitis 10.3
17 thrombocytopenic purpura, autoimmune 10.1
18 hydrops fetalis, nonimmune 10.1
19 nonarteritic anterior ischemic optic neuropathy 10.1
20 kawasaki disease 10.1
21 deficiency anemia 10.1
22 exanthema subitum 10.1
23 lymphocytic leukemia 10.1
24 fetal erythroblastosis 10.1
25 hemopericardium 10.1
26 pericardial effusion 10.1
27 hereditary spherocytosis 10.1
28 urticaria 10.1
29 optic nerve disease 10.1
30 glomerulonephritis 10.1
31 myelitis 10.1
32 brachial plexus neuritis 10.1
33 proliferative glomerulonephritis 10.1
34 congestive heart failure 10.1
35 collagen disease 10.1
36 neuropathy 10.1
37 transverse myelitis 10.1
38 encephalopathy 10.1
39 immune hydrops fetalis 10.1
40 catastrophic antiphospholipid syndrome 9.8 CD40LG APOH
41 antiphospholipid syndrome 9.8 CD40LG APOH
42 legg-calve-perthes disease 9.7 CD40LG APOH
43 syphilis 9.7 CD40LG APOH
44 psoriatic arthritis 9.7
45 acute hemorrhagic conjunctivitis 9.7
46 lyme disease 9.7
47 lymphadenitis 9.7
48 gastroenteritis 9.7
49 bronchiolitis 9.7
50 conjunctivitis 9.7

Graphical network of the top 20 diseases related to Erythema Infectiosum:



Diseases related to Erythema Infectiosum

Symptoms & Phenotypes for Erythema Infectiosum

UMLS symptoms related to Erythema Infectiosum:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Erythema Infectiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 APOH CD40LG FBN2 FKTN PIN1 SLC45A2
2 vision/eye MP:0005391 8.92 BMP2K FBN2 PIN1 SLC45A2

Drugs & Therapeutics for Erythema Infectiosum

Drugs for Erythema Infectiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1, Phase 2
2 Immunologic Factors Phase 1, Phase 2
3 Adjuvants, Immunologic Phase 1, Phase 2
4 MF59 oil emulsion Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Study of the Safety and Immunogenicity of a Recombinant Human Parvovirus B-19 Vaccine Terminated NCT00379938 Phase 1, Phase 2 Placebo
2 Investigation in Sickle Cell Disease of a New Reagent Assay Examining Natural Parvovirus B19 Infection Completed NCT02261480

Search NIH Clinical Center for Erythema Infectiosum

Cochrane evidence based reviews: erythema infectiosum

Genetic Tests for Erythema Infectiosum

Anatomical Context for Erythema Infectiosum

MalaCards organs/tissues related to Erythema Infectiosum:

41
Skin, Bone, Bone Marrow, Liver, Testes, B Cells, Kidney

Publications for Erythema Infectiosum

Articles related to Erythema Infectiosum:

(show top 50) (show all 543)
# Title Authors PMID Year
1
Parvovirus B19 Infection as a Rare Cause of Fulminant Liver Failure: A Case Report. 17
31101193 2019
2
Pure Red Cell Aplasia After Kidney Transplantation: Parvovirus B19 Culprit or Coincidence? 17
30833537 2019
3
Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19. 17
30875983 2019
4
Prokaryotic expression of a VP1 polypeptide antigen for diagnosis by a human parvovirus B19 antibody enzyme immunoassay. 9 38
1537897 1992
5
Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. 9 38
1765775 1991
6
Oral fluid: Non-invasive alternative for parvovirus B19 diagnosis? 38
31128380 2019
7
Human parvovirus B19 infection in patients with or without underlying diseases. 38
31257106 2019
8
Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody. 38
30787153 2019
9
[Erythrovirus B19 infections. Six years of follow-up in adults and children]. 38
31056091 2019
10
Clinical management of an adult with erythema infectiosum: a retrospective case report. 38
31057177 2019
11
Seroprevalence of antibodies to primate erythroparvovirus 1 (B19V) in Australia. 38
30526514 2018
12
Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank. 38
30602980 2018
13
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. 38
29967156 2018
14
Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant. 38
29853623 2018
15
RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication. 38
29437973 2018
16
Detection of parvovirus B19 in selected high-risk patient groups & their phylogenetic & selection analysis. 38
29998875 2018
17
Post-infectious acute glomerulonephritis with podocytopathy induced by parvovirus B19 infection. 38
29457859 2018
18
Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus. 38
28700372 2018
19
Parvovirus B19: What Is the Relevance in Transfusion Medicine? 38
29450198 2018
20
Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome. 38
29531655 2018
21
Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. 38
28512588 2017
22
Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil. 38
27914222 2017
23
DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain. 38
27809499 2016
24
The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. 38
27690083 2016
25
[Seroprevalence of human parvovirus B19 in children with fever and rash in the North of Tunisia]. 38
27385036 2016
26
Focal epilepsy as a long term sequela of Parvovirus B19 encephalitis. 38
27130981 2016
27
Seroprevalence of erythrovirus B19 in Saudi pregnant women. 38
27186157 2016
28
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease. 38
26644521 2016
29
The Receptor-Binding Domain in the VP1u Region of Parvovirus B19. 38
26927158 2016
30
Update of the human parvovirus B19 biology. 38
26778837 2016
31
Splenic infarcts as a rare manifestation of parvovirus B19 infection. 38
27213135 2016
32
Viral Skin Diseases. 38
26612372 2015
33
Proposition of real-time precise prediction model of infectious disease patients from Prescription Surveillance using the National Database of Electronic Medical Claims. 38
26320387 2015
34
Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults. 38
25965702 2015
35
Common Skin Rashes in Children. 38
26280141 2015
36
[Parvovirus B19 infection and pregnancy]. 38
26044725 2015
37
Parvovirus B19 infection as a cause of acute myositis in an adult. 38
25839959 2015
38
Three Adult Cases of HPV-B19 Infection with Concomitant Leukopenia and Low Platelet Counts. 38
25780346 2015
39
Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis. 38
24962467 2014
40
Parvovirus B19 infection in pregnancy. 38
25668048 2014
41
Petechial rash associated with Parvovirus B19 in children: case report and literature review. 38
25269970 2014
42
Persistence of human parvovirus B19 in tissues from adult individuals: a comparison with serostatus and its clinical utility. 38
24777824 2014
43
Human parvovirus B19 in Iranian pregnant women: a serologic survey. 38
25118740 2014
44
Rhabdomyolysis associated with human parvovirus B19 infection in a patient with Fukuyama-type congenital muscular dystrophy. 38
23594821 2014
45
[Reactivation of parvovirus B19 infection in an HIV-infected woman]. 38
23791089 2014
46
An unusual cause of cerebellar ataxia in an immunocompromised elderly patient. 38
24635888 2014
47
[Clinical and biological manifestations in primary parvovirus B19 infection in immunocompetent adult: a retrospective study of 26 cases]. 38
23773900 2014
48
Acute transverse myelitis associated with human parvovirus b19 infection. 38
24049056 2014
49
Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent. 38
24410941 2014
50
Human parvovirus B19: a review. 38
25283854 2014

Variations for Erythema Infectiosum

Expression for Erythema Infectiosum

Search GEO for disease gene expression data for Erythema Infectiosum.

Pathways for Erythema Infectiosum

GO Terms for Erythema Infectiosum

Sources for Erythema Infectiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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