MCID: ERY002
MIFTS: 35

Erythema Infectiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Erythema Infectiosum

MalaCards integrated aliases for Erythema Infectiosum:

Name: Erythema Infectiosum 12 54 44 15 17 71
Fifth Disease 12 74 42 3

Classifications:



External Ids:

Disease Ontology 12 DOID:8743
ICD9CM 34 057.0
MeSH 44 D016731
NCIt 50 C84695
SNOMED-CT 67 34730008
ICD10 32 B08.3
UMLS 71 C0085273

Summaries for Erythema Infectiosum

MedlinePlus : 42 Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low fever, cold symptoms, and a headache. Then you get a red rash on your face. It looks like a "slapped cheek." The rash can spread to the arms, legs, and trunk. Adults who get it might also have joint pain and swelling. Fifth disease spreads easily, through saliva and mucus. You can get it when an infected person coughs or sneezes. Frequently washing your hands might help prevent getting the virus. Most people become immune to the virus after having it once. Fifth disease is usually mild and goes away on its own. However, it can be serious if you Are pregnant Are anemic Have cancer or a weak immune system Centers for Disease Control and Prevention

MalaCards based summary : Erythema Infectiosum, also known as fifth disease, is related to parvovirus antenatal infection and exanthem, and has symptoms including fever, pruritus and exanthema. An important gene associated with Erythema Infectiosum is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and MF59 oil emulsion have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and kidney.

CDC : 3 Parvovirus B19 infects only humans. It most commonly causes fifth disease, a mild rash illness that usually affects children. But it can cause different signs and symptoms, depending on your age and overall health. Many people infected with parvovirus B19 do not have any symptoms, or they have only mild, nonspecific rash illness, not unlike the common cold.

Wikipedia : 74 Erythema infectiosum or fifth disease is one of several possible manifestations of infection by... more...

Related Diseases for Erythema Infectiosum

Diseases related to Erythema Infectiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 parvovirus antenatal infection 11.2
2 exanthem 10.7
3 rubella 10.5
4 hydrops fetalis, nonimmune 10.4
5 purpura 10.3
6 arthropathy 10.3
7 hemolytic anemia 10.3
8 measles 10.3
9 calciphylaxis 10.2 EPO CD40LG
10 geotrichosis 10.2 CD40LG CD4
11 myositis 10.2
12 aseptic meningitis 10.2
13 thrombocytopenia 10.2
14 neuritis 10.2
15 meningitis 10.2
16 congenital syphilis 10.2 CD40LG CD4
17 secondary syphilis 10.2 CD40LG CD4
18 sporotrichosis 10.1 CD40LG CD4
19 immunodeficiency with hyper-igm, type 3 10.1 CD40LG CD4
20 congenital toxoplasmosis 10.1 CD40LG CD4
21 ceftazidime allergy 10.1 EPO CD4
22 pneumocystosis 10.1 CD40LG CD4
23 catastrophic antiphospholipid syndrome 10.1 CD40LG APOH
24 primary thrombocytopenia 10.1 CD40LG CD4
25 splenic sequestration 10.1 EPO CD4
26 miliary tuberculosis 10.1 EPO CD4
27 cryptosporidiosis 10.1 CD40LG CD4
28 iritis 10.1 EPO CD4
29 immunoglobulin alpha deficiency 10.1 CD40LG CD4
30 anemia, autoimmune hemolytic 10.1 CD40LG CD4
31 acute diarrhea 10.0 CD4 ASZ1
32 legg-calve-perthes disease 10.0 CD40LG APOH
33 autoimmune disease of blood 10.0 CD40LG CD4
34 hypersplenism 10.0 EPO CD4
35 thrombocytopenic purpura, autoimmune 10.0
36 nonarteritic anterior ischemic optic neuropathy 10.0
37 kawasaki disease 10.0
38 exanthema subitum 10.0
39 transverse myelitis 10.0
40 fetal erythroblastosis 10.0
41 hemopericardium 10.0
42 pericardial effusion 10.0
43 hereditary spherocytosis 10.0
44 urticaria 10.0
45 optic nerve disease 10.0
46 glomerulonephritis 10.0
47 myelitis 10.0
48 brachial plexus neuritis 10.0
49 proliferative glomerulonephritis 10.0
50 collagen disease 10.0

Graphical network of the top 20 diseases related to Erythema Infectiosum:



Diseases related to Erythema Infectiosum

Symptoms & Phenotypes for Erythema Infectiosum

UMLS symptoms related to Erythema Infectiosum:


fever, pruritus, exanthema

Drugs & Therapeutics for Erythema Infectiosum

Drugs for Erythema Infectiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1, Phase 2
2 MF59 oil emulsion Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Study of the Safety and Immunogenicity of a Recombinant Human Parvovirus B-19 Vaccine Terminated NCT00379938 Phase 1, Phase 2 Placebo
2 Investigation in Sickle Cell Disease of a New Reagent Assay Examining Natural Parvovirus B19 Infection Completed NCT02261480

Search NIH Clinical Center for Erythema Infectiosum

Cochrane evidence based reviews: erythema infectiosum

Genetic Tests for Erythema Infectiosum

Anatomical Context for Erythema Infectiosum

MalaCards organs/tissues related to Erythema Infectiosum:

40
Skin, Bone Marrow, Kidney, Neutrophil, Myeloid, T Cells, Endothelial

Publications for Erythema Infectiosum

Articles related to Erythema Infectiosum:

(show top 50) (show all 557)
# Title Authors PMID Year
1
High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study. 42
32927082 2020
2
A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana. 42
32973247 2020
3
Parvovirus B19 infection masquerading as relapsed acute lymphoblastic leukaemia following haematopoietic stem cell transplantation. 42
32816883 2020
4
Prokaryotic expression of a VP1 polypeptide antigen for diagnosis by a human parvovirus B19 antibody enzyme immunoassay. 54 61
1537897 1992
5
Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. 61 54
1765775 1991
6
Comprehensive surveillance data suggest a prominent role of parvovirus B19 infection in Belarus and the presence of a third subtype within subgenotype 1a. 61
33441645 2021
7
Identification and management of congenital parvovirus B19 infection. 61
32860469 2020
8
A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients. 61
33292852 2020
9
Parvovirus-Induced Transient Aplastic Crisis in a Patient With Newly Diagnosed Hereditary Spherocytosis. 61
32775077 2020
10
Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy. 61
32646497 2020
11
Parvovirus B19 Infection Mimicking Juvenile Myelomonocytic Leukemia in an Immunocompetent Child. 61
32754395 2020
12
Healthcare-Associated Transmission of Parvovirus B19 Arthropathy. 61
32510300 2020
13
Exanthematous Eruptions in Children. 61
32155277 2020
14
Leukoerythroblastosis as an Unusual Presentation of Parvovirus B19 Infection in a Sickle Cell Patient. 61
33029441 2020
15
The rash with mucosal ulceration. 61
32197747 2020
16
Prevalence of Human Parvovirus B19 in Neurological Patients: Findings from Region of Western Saudi Arabia. 61
32637161 2020
17
The Role of Human Parvovirus B19 in the Pediatric Patients with Pancytopenia? 61
31850715 2019
18
Oral fluid: Non-invasive alternative for parvovirus B19 diagnosis? 61
31128380 2019
19
Human parvovirus B19 infection in patients with or without underlying diseases. 61
31257106 2019
20
Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody. 61
30787153 2019
21
[Erythrovirus B19 infections. Six years of follow-up in adults and children]. 61
31056091 2019
22
Clinical management of an adult with erythema infectiosum: a retrospective case report. 61
31057177 2019
23
A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder. 61
31763347 2019
24
Seroprevalence of antibodies to primate erythroparvovirus 1 (B19V) in Australia. 61
30526514 2018
25
Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank. 61
30602980 2018
26
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. 61
29967156 2018
27
Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant. 61
29853623 2018
28
Detection of parvovirus B19 in selected high-risk patient groups & their phylogenetic & selection analysis. 61
29998875 2018
29
RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication. 61
29437973 2018
30
Post-infectious acute glomerulonephritis with podocytopathy induced by parvovirus B19 infection. 61
29457859 2018
31
Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus. 61
28700372 2018
32
Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome. 61
29531655 2018
33
Parvovirus B19: What Is the Relevance in Transfusion Medicine? 61
29450198 2018
34
Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. 61
28512588 2017
35
Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil. 61
27914222 2017
36
DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain. 61
27809499 2016
37
The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. 61
27690083 2016
38
[Seroprevalence of human parvovirus B19 in children with fever and rash in the North of Tunisia]. 61
27385036 2016
39
Focal epilepsy as a long term sequela of Parvovirus B19 encephalitis. 61
27130981 2016
40
Seroprevalence of erythrovirus B19 in Saudi pregnant women. 61
27186157 2016
41
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease. 61
26644521 2016
42
Update of the human parvovirus B19 biology. 61
26778837 2016
43
The Receptor-Binding Domain in the VP1u Region of Parvovirus B19. 61
26927158 2016
44
Splenic infarcts as a rare manifestation of parvovirus B19 infection. 61
27213135 2016
45
Viral Skin Diseases. 61
26612372 2015
46
Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults. 61
25965702 2015
47
Proposition of real-time precise prediction model of infectious disease patients from Prescription Surveillance using the National Database of Electronic Medical Claims. 61
26320387 2015
48
Common Skin Rashes in Children. 61
26280141 2015
49
Une question de terrain : signification de la persistance de l'ADN du parvovirus B19. 61
33065903 2015
50
[Parvovirus B19 infection and pregnancy]. 61
26044725 2015

Variations for Erythema Infectiosum

Expression for Erythema Infectiosum

Search GEO for disease gene expression data for Erythema Infectiosum.

Pathways for Erythema Infectiosum

Pathways related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 CD40LG CD4

GO Terms for Erythema Infectiosum

Cellular components related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 SLC1A4 EPO CD40LG CD4 APOH

Biological processes related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.56 XRCC5 RBM38 DNAJB14 CD4
2 tRNA modification GO:0006400 9.16 ADAT3 ADAT2
3 positive regulation of protein kinase activity GO:0045860 9.13 XRCC5 EPO CD4
4 negative regulation of myeloid cell apoptotic process GO:0033033 8.62 EPO APOH

Molecular functions related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA-specific adenosine-34 deaminase activity GO:0052717 8.62 ADAT3 ADAT2

Sources for Erythema Infectiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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