MCID: ERY002
MIFTS: 33

Erythema Infectiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Erythema Infectiosum

MalaCards integrated aliases for Erythema Infectiosum:

Name: Erythema Infectiosum 12 54 43 15 17 71
Fifth Disease 12 74 42 3

Classifications:



External Ids:

Disease Ontology 12 DOID:8743
ICD9CM 34 057.0
MeSH 43 D016731
NCIt 49 C84695
SNOMED-CT 67 34730008
ICD10 32 B08.3
UMLS 71 C0085273

Summaries for Erythema Infectiosum

MedlinePlus : 42 Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low fever, cold symptoms, and a headache. Then you get a red rash on your face. It looks like a "slapped cheek." The rash can spread to the arms, legs, and trunk. Adults who get it might also have joint pain and swelling. Fifth disease spreads easily, through saliva and mucus. You can get it when an infected person coughs or sneezes. Frequently washing your hands might help prevent getting the virus. Most people become immune to the virus after having it once. Fifth disease is usually mild and goes away on its own. However, it can be serious if you Are pregnant Are anemic Have cancer or a weak immune system Centers for Disease Control and Prevention

MalaCards based summary : Erythema Infectiosum, also known as fifth disease, is related to exanthem and parvovirus antenatal infection, and has symptoms including fever, pruritus and exanthema. An important gene associated with Erythema Infectiosum is CD40LG (CD40 Ligand). The drugs MF59 oil emulsion and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow.

CDC : 3 Parvovirus B19 infects only humans. It most commonly causes fifth disease, a mild rash illness that usually affects children. But it can cause different signs and symptoms, depending on your age and overall health. Many people infected with parvovirus B19 do not have any symptoms, or they have only mild, nonspecific rash illness, not unlike the common cold.

Wikipedia : 74 Erythema infectiosum or fifth disease is one of several possible manifestations of infection by... more...

Related Diseases for Erythema Infectiosum

Diseases related to Erythema Infectiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 exanthem 31.5 SENP8 CD40LG
2 parvovirus antenatal infection 11.5
3 rubella 10.6
4 hydrops fetalis, nonimmune 10.5
5 purpura 10.4
6 arthropathy 10.4
7 hemolytic anemia 10.4
8 measles 10.4
9 dilated cardiomyopathy 1t 10.3 GPR180 CD40LG
10 myositis 10.3
11 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.3
12 deficiency anemia 10.3
13 aseptic meningitis 10.3
14 thrombocytopenia 10.3
15 neuritis 10.3
16 arthritis 10.3
17 meningitis 10.3
18 encephalitis 10.3
19 splenic sequestration 10.2 EPO CD40LG
20 miliary tuberculosis 10.2 EPO CD40LG
21 calciphylaxis 10.2 EPO CD40LG
22 iritis 10.2 EPO CD40LG
23 kunjin encephalitis 10.1 SENP8 CD40LG
24 kyasanur forest disease 10.1 SENP8 CD40LG
25 pure red-cell aplasia 10.1 EPO CD40LG
26 st. louis encephalitis 10.1 SENP8 CD40LG
27 thrombocytopenic purpura, autoimmune 10.1
28 nonarteritic anterior ischemic optic neuropathy 10.1
29 kawasaki disease 10.1
30 exanthema subitum 10.1
31 fetal erythroblastosis 10.1
32 hemopericardium 10.1
33 pericardial effusion 10.1
34 hereditary spherocytosis 10.1
35 urticaria 10.1
36 optic nerve disease 10.1
37 glomerulonephritis 10.1
38 myelitis 10.1
39 brachial plexus neuritis 10.1
40 proliferative glomerulonephritis 10.1
41 congestive heart failure 10.1
42 collagen disease 10.1
43 neuropathy 10.1
44 transverse myelitis 10.1
45 encephalopathy 10.1
46 immune hydrops fetalis 10.1
47 acalculous cholecystitis 10.1 SENP8 CD40LG
48 asymptomatic dengue 10.1 SENP8 CD40LG
49 murray valley encephalitis 10.1 SENP8 CD40LG
50 zika fever 10.1 SENP8 CD40LG

Graphical network of the top 20 diseases related to Erythema Infectiosum:



Diseases related to Erythema Infectiosum

Symptoms & Phenotypes for Erythema Infectiosum

UMLS symptoms related to Erythema Infectiosum:


fever, pruritus, exanthema

Drugs & Therapeutics for Erythema Infectiosum

Drugs for Erythema Infectiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 MF59 oil emulsion Phase 1, Phase 2
2 Vaccines Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Study of the Safety and Immunogenicity of a Recombinant Human Parvovirus B-19 Vaccine Terminated NCT00379938 Phase 1, Phase 2 Placebo
2 Investigation in Sickle Cell Disease of a New Reagent Assay Examining Natural Parvovirus B19 Infection Completed NCT02261480

Search NIH Clinical Center for Erythema Infectiosum

Cochrane evidence based reviews: erythema infectiosum

Genetic Tests for Erythema Infectiosum

Anatomical Context for Erythema Infectiosum

MalaCards organs/tissues related to Erythema Infectiosum:

40
Skin, Bone, Bone Marrow, Liver, Testes, B Cells, T Cells

Publications for Erythema Infectiosum

Articles related to Erythema Infectiosum:

(show top 50) (show all 547)
# Title Authors PMID Year
1
The Role of Human Parvovirus B19 in the Pediatric Patients with Pancytopenia? 42 61
31850715 2019
2
Overall prevalence of human parvovirus B19 among blood donors in mainland China: A PRISMA-compliant meta-analysis. 42
32332630 2020
3
A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease. 42
31886191 2019
4
Prokaryotic expression of a VP1 polypeptide antigen for diagnosis by a human parvovirus B19 antibody enzyme immunoassay. 54 61
1537897 1992
5
Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. 54 61
1765775 1991
6
Healthcare-Associated Transmission of Parvovirus B19 Arthropathy. 61
32510300 2020
7
Exanthematous Eruptions in Children. 61
32155277 2020
8
The rash with mucosal ulceration. 61
32197747 2020
9
Oral fluid: Non-invasive alternative for parvovirus B19 diagnosis? 61
31128380 2019
10
Human parvovirus B19 infection in patients with or without underlying diseases. 61
31257106 2019
11
[Erythrovirus B19 infections. Six years of follow-up in adults and children]. 61
31056091 2019
12
Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody. 61
30787153 2019
13
Clinical management of an adult with erythema infectiosum: a retrospective case report. 61
31057177 2019
14
A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder. 61
31763347 2019
15
Seroprevalence of antibodies to primate erythroparvovirus 1 (B19V) in Australia. 61
30526514 2018
16
Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank. 61
30602980 2018
17
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. 61
29967156 2018
18
Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant. 61
29853623 2018
19
Detection of parvovirus B19 in selected high-risk patient groups & their phylogenetic & selection analysis. 61
29998875 2018
20
RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication. 61
29437973 2018
21
Post-infectious acute glomerulonephritis with podocytopathy induced by parvovirus B19 infection. 61
29457859 2018
22
Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus. 61
28700372 2018
23
Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome. 61
29531655 2018
24
Parvovirus B19: What Is the Relevance in Transfusion Medicine? 61
29450198 2018
25
Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. 61
28512588 2017
26
Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil. 61
27914222 2017
27
DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain. 61
27809499 2016
28
The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. 61
27690083 2016
29
[Seroprevalence of human parvovirus B19 in children with fever and rash in the North of Tunisia]. 61
27385036 2016
30
Focal epilepsy as a long term sequela of Parvovirus B19 encephalitis. 61
27130981 2016
31
Seroprevalence of erythrovirus B19 in Saudi pregnant women. 61
27186157 2016
32
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease. 61
26644521 2016
33
The Receptor-Binding Domain in the VP1u Region of Parvovirus B19. 61
26927158 2016
34
Update of the human parvovirus B19 biology. 61
26778837 2016
35
Splenic infarcts as a rare manifestation of parvovirus B19 infection. 61
27213135 2016
36
Viral Skin Diseases. 61
26612372 2015
37
Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults. 61
25965702 2015
38
Proposition of real-time precise prediction model of infectious disease patients from Prescription Surveillance using the National Database of Electronic Medical Claims. 61
26320387 2015
39
Common Skin Rashes in Children. 61
26280141 2015
40
[Parvovirus B19 infection and pregnancy]. 61
26044725 2015
41
Parvovirus B19 infection as a cause of acute myositis in an adult. 61
25839959 2015
42
Three Adult Cases of HPV-B19 Infection with Concomitant Leukopenia and Low Platelet Counts. 61
25780346 2015
43
Parvovirus B19 infection in pregnancy. 61
25668048 2014
44
Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis. 61
24962467 2014
45
Persistence of human parvovirus B19 in tissues from adult individuals: a comparison with serostatus and its clinical utility. 61
24777824 2014
46
Petechial rash associated with Parvovirus B19 in children: case report and literature review. 61
25269970 2014
47
Rhabdomyolysis associated with human parvovirus B19 infection in a patient with Fukuyama-type congenital muscular dystrophy. 61
23594821 2014
48
Human parvovirus B19 in Iranian pregnant women: a serologic survey. 61
25118740 2014
49
[Reactivation of parvovirus B19 infection in an HIV-infected woman]. 61
23791089 2014
50
[Clinical and biological manifestations in primary parvovirus B19 infection in immunocompetent adult: a retrospective study of 26 cases]. 61
23773900 2014

Variations for Erythema Infectiosum

Expression for Erythema Infectiosum

Search GEO for disease gene expression data for Erythema Infectiosum.

Pathways for Erythema Infectiosum

GO Terms for Erythema Infectiosum

Biological processes related to Erythema Infectiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase activity GO:0045860 8.96 XRCC5 EPO
2 oligosaccharide biosynthetic process GO:0009312 8.62 MPDU1 B3GALNT1

Sources for Erythema Infectiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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