EM
MCID: ERY003
MIFTS: 58

Erythema Multiforme (EM)

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erythema Multiforme

MalaCards integrated aliases for Erythema Multiforme:

Name: Erythema Multiforme 12 76 53 37 55 44 15 73
Erythema Polymorphe, Erythema Multiforme Type 53
Dermatostomatitis, Erythema Multiforme Type 53
Herpes Iris, Erythema Multiforme Type 53
Febrile Mucocutaneous Syndrome 53
Erythema Multiforme Bullosum 53
Stevens-Johnson Syndrome 73
Em 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0050185
MeSH 44 D004892
KEGG 37 H01695
ICD10 33 L51

Summaries for Erythema Multiforme

NIH Rare Diseases : 53 Erythema multiforme (EM) refers to a group of hypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus, suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome. The most severe of the three is toxic epidermal necrolysis (TEN).

MalaCards based summary : Erythema Multiforme, also known as erythema polymorphe, erythema multiforme type, is related to severe cutaneous adverse reaction and pulmonary fibrosis, idiopathic. An important gene associated with Erythema Multiforme is DSP (Desmoplakin), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A skin disease that is a type of allergic reaction located in skin, which occurs in response to medications, infections, or illness.

Wikipedia : 76 Erythema multiforme (EM) is a skin condition of unknown cause; it is a type of erythema possibly... more...

Related Diseases for Erythema Multiforme

Diseases related to Erythema Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 31.9 FASLG GZMB TNF
2 pulmonary fibrosis, idiopathic 31.3 CCL17 CXCR3 DSP FASLG IFNG TNF
3 viral infectious disease 30.7 IFNG IL2 TNF
4 contact dermatitis 30.5 CCL17 CXCR3 ICAM1 IFNG TNF
5 fixed drug eruption 30.5 IFNG IL2
6 stevens-johnson syndrome/toxic epidermal necrolysis 30.3 CCL17 CXCR3 IFNG IL2
7 human immunodeficiency virus infectious disease 30.3 IFNG IL2 TNF
8 chronic graft versus host disease 30.2 IFNG TNF
9 colitis 30.2 IFNG IL2 TNF
10 ulcerative colitis 30.2 IFNG IL2 TNF
11 allergic contact dermatitis 30.1 CCL17 CXCR3 ICAM1 IFNG TNF
12 myocarditis 29.9 DSP ICAM1 TNF
13 hematopoietic stem cell transplantation 29.9 IFNG IL2 TNF
14 smallpox 29.9 IFNG IL2 TNF
15 mumps 29.9 IFNG IL2 TNF
16 graft-versus-host disease 29.8 FASLG GZMB IFNG IL2 TNF
17 lymphopenia 29.8 FASLG IFNG IL2
18 orofacial granulomatosis 29.7 CXCR3 IFNG TNF
19 keratoconjunctivitis 29.6 CCL17 ICAM1 IFNG IL2 TNF
20 lichen planus 29.6 CXCR3 GZMB ICAM1 IFNG TNF
21 rheumatoid arthritis 29.6 ICAM1 IFNG IL2 TNF
22 cutaneous lupus erythematosus 29.6 CXCR3 GZMB ICAM1 TNF
23 hemophagocytic lymphohistiocytosis 29.6 GZMB IFNG TNF
24 autoimmune disease 29.5 CXCR3 IFNG IL2 TNF
25 systemic lupus erythematosus 29.5 CXCR3 FASLG ICAM1 IFNG IL2 TNF
26 diabetes mellitus 29.4 FASLG IFNG IL2 TNF
27 psoriasis 29.4 CCL17 CXCR3 ICAM1 IFNG IL2 TNF
28 acute graft versus host disease 29.4 FASLG GZMB IFNG IL2 TNF
29 lymphadenitis 29.3 CXCR3 FASLG ICAM1 IFNG TNF
30 multiple sclerosis 29.1 CXCR3 ICAM1 IFNG IL2 TNF
31 dermatitis, atopic 29.1 CCL17 CXCR3 ICAM1 IFNG IL2 TNF
32 alopecia areata 29.0 FASLG GZMB ICAM1 IFNG IL2 TNF
33 erythema multiforme major 12.5
34 eosinophilia-myalgia syndrome 12.3
35 epileptic encephalopathy, early infantile, 3 11.4
36 epileptic encephalopathy, early infantile, 4 11.4
37 erythromelalgia 11.3
38 pseudomembranous conjunctivitis 11.2
39 pulmonary embolism 11.2
40 encephalopathy, ethylmalonic 11.0
41 alpha-1-antitrypsin deficiency 11.0
42 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.8
43 dermatitis 10.8
44 herpes simplex 10.8
45 lupus erythematosus 10.5
46 hepatitis 10.4
47 cardiac arrest 10.4
48 hepatitis b 10.3
49 lymphoma 10.3
50 syphilis 10.3

Comorbidity relations with Erythema Multiforme via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Erythema Multiforme:



Diseases related to Erythema Multiforme

Symptoms & Phenotypes for Erythema Multiforme

GenomeRNAi Phenotypes related to Erythema Multiforme according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 GZMB ICAM1 IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 FASLG GZMB ICAM1 IL2 TNF

MGI Mouse Phenotypes related to Erythema Multiforme:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 CCL17 CXCR3 DSP FASLG ICAM1 IFNG
2 cardiovascular system MP:0005385 10.02 CXCR3 DSP FASLG ICAM1 IFNG IL2
3 hematopoietic system MP:0005397 9.97 ATF3 CCL17 CXCR3 FASLG ICAM1 IFNG
4 immune system MP:0005387 9.92 ATF3 CCL17 CXCR3 FASLG ICAM1 IFNG
5 digestive/alimentary MP:0005381 9.91 DSP FASLG ICAM1 IFNG IL2 TNF
6 endocrine/exocrine gland MP:0005379 9.88 ATF3 FASLG ICAM1 IFNG IL2 TNF
7 integument MP:0010771 9.73 ATF3 DSP FASLG ICAM1 IFNG TNF
8 neoplasm MP:0002006 9.7 ATF3 CXCR3 FASLG ICAM1 IFNG IL2
9 respiratory system MP:0005388 9.43 ATF3 CXCR3 FASLG IFNG IL2 TNF
10 vision/eye MP:0005391 9.1 ATF3 FASLG ICAM1 IFNG IL2 TNF

Drugs & Therapeutics for Erythema Multiforme

Drugs for Erythema Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 791)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
5
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
6
Cilostazol Approved, Investigational Phase 4,Not Applicable 73963-72-1 2754
7
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
8
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
9
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
10
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33069-62-4 36314
11
Chromium Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-47-3 27668
12
Cobalt Approved, Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-48-4 104729
13
Ethanol Approved Phase 4,Phase 2,Not Applicable 64-17-5 702
14
Benzoyl peroxide Approved Phase 4,Phase 3 94-36-0 7187
15
Coal tar Approved Phase 4,Phase 3,Phase 2,Phase 1 8007-45-2
16
Pemetrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 150399-23-8, 137281-23-3 446556 60843
17
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 41575-94-4 10339178 38904 498142
18
Gefitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 184475-35-2 123631
19
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15663-27-1 2767 441203 84093
20
Docetaxel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 114977-28-5 148124
21
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
22
Pantoprazole Approved Phase 4 102625-70-7 4679
23
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
24 Nutmeg Approved Phase 4,Phase 3,Phase 1,Not Applicable
25
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55-56-1 2713 9552079
26
Glucosamine Approved, Investigational Phase 4,Phase 3,Not Applicable 3416-24-8 439213
27
Abciximab Approved Phase 4,Phase 2,Phase 3 143653-53-6
28
Tirofiban Approved Phase 4,Not Applicable 144494-65-5 60947
29
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Not Applicable 274693-27-5 9871419
30
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128270-60-0 16129704
31
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
32
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
33
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 104987-11-3 445643 439492
34 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
36
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
37
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1 95058-81-4 60750
38
Sunitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 557795-19-4, 341031-54-7 5329102
39
Desonide Approved, Investigational Phase 4,Phase 3 638-94-8 5311066
40
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
41
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
42
Lenvatinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 417716-92-8
43
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 56420-45-2 41867
44
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
45
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
46
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 1,Phase 2 2921-57-5
47
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 83-43-2 6741
48
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 302-25-0
49
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-24-8 5755
50
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703

Interventional clinical trials:

(show top 50) (show all 4280)
# Name Status NCT ID Phase Drugs
1 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
2 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Unknown status NCT02563535 Phase 4
3 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
4 Zotarolimus and Everolimus-Eluting Stents ProsPectively Compared in Real World Unknown status NCT00768846 Phase 4
5 Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo Unknown status NCT01246921 Phase 4 Fluticasone proprionate 0.05% cream
6 CYPRESS - CYPHER for Evaluating Sustained Safety Unknown status NCT00954707 Phase 4 Clopidogrel & Aspirin, Prasugrel & Aspirin;Placebo & Aspirin
7 Efficacy and Safety of Xience in Coronary arEry Disease aLL-comers After stENTing Using the PRIME Platform (EXCELLENT-PRIME Registry) Unknown status NCT01605721 Phase 4
8 Comparison of Biomatrix and Orsiro Drug Eluting Stent Unknown status NCT02299011 Phase 4 Biomatrix drug eluting stent
9 Effects of Celecoxib On Restenosis After Coronary Intervention and Evolution of Atherosclerosis Trial Unknown status NCT00500279 Phase 4 Celecoxib
10 Small Coronary Artery Treated by TAXUS Liberté Registry in Japan Unknown status NCT00955214 Phase 4
11 Balloon Angioplasty Versus Xpert Stent in CLI Patients XXS Study Unknown status NCT00546845 Phase 4
12 Xience/Promus for Long Coronary Lesion Registry Unknown status NCT01147237 Phase 4
13 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
14 Efficacy and Safety of Paclitaxel-eluting Balloon for Treatment of Lesions in Native Small Coronary Arteries Unknown status NCT01903902 Phase 4
15 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
16 Italian Diffuse/Multivessel Disease ABSORB Prospective Registry: IT-Disappears Unknown status NCT02004730 Phase 4
17 Platelet Function Assessment for Atherothrombotic Patients Unknown status NCT00513149 Phase 4 Clopidogrel
18 Efficacy of Xience/Promus Versus Cypher in rEducing Late Loss After stENTing Unknown status NCT00698607 Phase 4 6-month clopidogrel therapy;12-month clopidogrel therapy
19 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
20 BIfurcation Optimal Treatment Strategy With LYMus Eluting Dedicated Bifurcation Versus Convention Stent Randomized Study Unknown status NCT01430364 Phase 4
21 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
22 Study of the Paclitaxel-Coated Balloon Catheter in Bifurcated Coronary Lesions Unknown status NCT01278186 Phase 4
23 Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis Unknown status NCT00152308 Phase 4
24 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
25 To Achieve an Early Reendothelialization at the Expense of Low Restenosis: The EREMUS Study Unknown status NCT00870038 Phase 4
26 The 001-DIOR Multicenter Registry Unknown status NCT01375465 Phase 4
27 Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples) Unknown status NCT01260571 Phase 4 Benzoyl peroxide and sulfur
28 Local Thrombolytics Before Thrombectomy in STEMI Unknown status NCT01568931 Phase 4 Urokinase;Saline
29 Optical Coherence Tomography (OCT) Evaluation of Re-endothelization: A Comparison of the Intrepide™ Stent Versus Taxus™ Unknown status NCT00914420 Phase 4
30 Impact of Intravascular Ultrasound(IVUS)-Guided Chronic Total Occlusion Intervention With Drug-eluting Stents Unknown status NCT01563952 Phase 4
31 Intercalated Combination of Chemotherapy and Tyrosine Kinase Inhibitors as First-line Treatment for Patients With Non-Small-Cell Lung Cancer Unknown status NCT02031601 Phase 4 Erlotinib;Gefitinib;Icotinib;Docetaxel;Pemetrexed;Platinum (cisplatin or carboplatin);Erlotinib;Gefitinib;Icotinib
32 Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN) Unknown status NCT01735227 Phase 4 omeprazole;Pantoprazole
33 Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Unknown status NCT01418794 Phase 4
34 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
35 Comparison of the Everolimus Eluting With the Biolimus A9 Eluting Stent Unknown status NCT01233453 Phase 4
36 A Study to Evaluate Safety and Efficacy of the ExcelTM Sirolimus Eluting Stent With a Biodegradable Polymer Versus Sirolimus Eluting Stent With Non-Biodegradable Polymer in the Treatment of Patients With de Novo Coronary Artery Lesions Unknown status NCT00825773 Phase 4
37 Treatment of Bifurcated Coronary Lesions With Cypher™-Stent Unknown status NCT00288535 Phase 4
38 Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI Unknown status NCT00229515 Phase 4
39 GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions Unknown status NCT00220558 Phase 4
40 Anti-Restenosis After AMI by Erythropoietin Unknown status NCT00423020 Phase 4 Erythropoietin
41 Efficacy and Safety of BiomatrixTM Stent and 5mg-Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome Unknown status NCT02446730 Phase 4 Prasugel;Clopidogrel
42 Comparison of the Efficacy of Paclitaxel-releasing Balloon Catheter System Versus the Everolimus-Eluting Stent System for Treatment of In-Stent Restenosis Lesions - Harmonizing Optimal Strategy for Treatment of In-Stent Restenosis Lesions (The HOST-ISR Trial) - Unknown status NCT01093300 Phase 4
43 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
44 Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers Unknown status NCT02618837 Phase 4
45 Efficacy of Thrombosuction in Primary Percutaneous Coronary Intervention of Acute Myocardial Infarction Unknown status NCT01156662 Phase 4
46 Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents Unknown status NCT02464397 Phase 4
47 The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy) Unknown status NCT02767401 Phase 4 aspirin, clopidogrel, ticagrelor, atorvastatin, rosuvastatin, betaloc
48 Efficacy and Safety of Nano+ Polymer-free Sirolimus-Eluting Stent: A Optical Coherent Tomography Study Unknown status NCT01925027 Phase 4
49 Subject Reported Target-lesion Numeric Rating Scale Evaluation by Subjects With Plaque Psoriasis Treated With Clobex® (Clobetasol Propionate) Spray 0.05% Completed NCT01893567 Phase 4 Clobex Spray
50 Randomized, Two-arm, Non-inferiority Study Comparing Endeavor-Resolute Stent With Abbot Xience-V Stent Completed NCT00617084 Phase 4

Search NIH Clinical Center for Erythema Multiforme

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: erythema multiforme

Genetic Tests for Erythema Multiforme

Anatomical Context for Erythema Multiforme

MalaCards organs/tissues related to Erythema Multiforme:

41
Skin, Eye, Testes, T Cells, Lung, Kidney, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Erythema Multiforme:

19
Skin

Publications for Erythema Multiforme

Articles related to Erythema Multiforme:

(show top 50) (show all 1014)
# Title Authors Year
1
Recurrent orogenital erythema multiforme and vulval neutrophilic dermatosis. ( 29901227 )
2018
2
A Case of Erythema Multiforme Major Developed after Sequential Use of Two Immune Checkpoint Inhibitors, Nivolumab and Ipilimumab, for Advanced Melanoma: Possible Implication of Synergistic and/or Complementary Immunomodulatory Effects. ( 29515387 )
2018
3
From HSV infection to erythema multiforme through autoimmune crossreactivity. ( 29635075 )
2018
4
Segmental Erythema Multiforme-Like Drug Eruption by Aromatase Inhibitor Anastrozole - First Case Report and another Example of an Immunocompromised District. ( 29483990 )
2018
5
Atypical Still disease with necrotic keratinocytes: A histologic mimicker of erythema multiforme. ( 29693054 )
2018
6
A Large Epidemiological Study Of Erythema Multiforme In France, With Emphasis On Treatment Choices. ( 29957881 )
2018
7
Erythema multiforme after orf virus infection. ( 29766553 )
2018
8
Urticaria multiforme, an "erythema multiforme" simulator. ( 29398004 )
2018
9
Tularemia-induced erythema multiforme minor in an 11-year-old girl. ( 29582465 )
2018
10
Characteristics of pediatric recurrent erythema multiforme. ( 29231254 )
2018
11
Lenalidomide as an Alternative to Thalidomide for Treatment of Recurrent Erythema Multiforme. ( 29450445 )
2018
12
Pediatric Lip Adhesion Following Bullous Erythema Multiforme and Review of Similar Oral Complications. ( 29463113 )
2018
13
Reactive perforating leprosy, erythema multiforme-like reactions, sweet's syndrome-like reactions as atypical clinical manifestations of Type 2 leprosy reaction. ( 29516895 )
2018
14
Current Perspectives on Erythema Multiforme. ( 29352387 )
2018
15
Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database. ( 29387340 )
2018
16
Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes. ( 29559400 )
2018
17
Erythema Multiforme Major After Immunotherapy With Diphenylcyclopropenone for Alopecia Areata. ( 30346328 )
2018
18
Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. ( 30186440 )
2018
19
Golimumab-associated persistent erythema multiforme in a patient with ulcerative colitis in full remission. ( 30142713 )
2018
20
Erythema multiforme-like contact dermatitis caused by herbal medicine. ( 30411366 )
2018
21
Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease. ( 30024055 )
2018
22
Drug-induced oral erythema multiforme: A diagnostic challenge. ( 29363636 )
2018
23
Erythema multiforme major induced by exotic wood. ( 29987843 )
2018
24
The effect of levamisole in the treatment of recalcitrant recurrent erythema multiforme major: An observational study. ( 30143369 )
2018
25
Erythema multiforme major with swollen lips and crusted erosions. ( 30152391 )
2018
26
Case of Erythema Multiforme Drug Eruption Induced by Ledipasvir/Sofosbuvir. ( 30188425 )
2018
27
Histopathology of Hand-Foot-Mouth Disease in Adults and Criteria for Differentiation From Erythema Multiforme. ( 30211734 )
2018
28
Severe hand-foot skin reaction and erythema multiforme-like lesions due to sorafenib. ( 30224351 )
2018
29
A Rare Case Report of Giant Cell Tumor of the Sphenoid Bone in a Patient Who Developed "Erythema Multiforme Associated with Phenytoin and Cranial Radiation Therapy Syndrome". ( 30283572 )
2018
30
Postpartum eruption of enoxaparin-induced erythema multiforme. ( 30349708 )
2018
31
Deflazacort-Induced Erythema Multiforme Exudativum Successfully Treated With a Single Dose of Etanercept. ( 30350788 )
2018
32
Polymorphous Light Eruption Mimicking Erythema Multiforme. ( 30373707 )
2018
33
Case of Erythema Multiforme Drug Eruption Induced by Ledipasvir/Sofosbuvir: Erratum. ( 30398997 )
2018
34
Herpes-Associated Erythema Multiforme. ( 30476966 )
2018
35
Secondary syphilis presenting as erythema multiforme in a HIV-positive homosexual man: a case report and literature review. ( 30482099 )
2018
36
Erythema multiforme as a reaction to imiquimod 5% cream. ( 28329504 )
2017
37
Contact dermatitis caused by Geranium robertianum with erythema multiforme-like reaction. ( 29164698 )
2017
38
Erythema multiforme following pneumococcal vaccination. ( 28352933 )
2017
39
Autoimmune progesterone dermatitis manifesting as mucosal erythema multiforme in the setting of HIV infection. ( 28050592 )
2017
40
Risperidone-induced Erythema Multiforme Minor. ( 29284818 )
2017
41
Erythema multiforme-like reaction resulting from vitamin K<sub>1</sub>oxide (phytomenadione epoxide). ( 29063687 )
2017
42
Erythema multiforme-like lesions in primary cutaneous aggressive cytotoxic epidermotropic CD8+ T-cell lymphoma: A diagnostic and therapeutic challenge. ( 28644551 )
2017
43
Erythema multiforme induced by alendronate sodium in a geriatric patient: A case report and review of the literature. ( 28828163 )
2017
44
New Presentation of Autoimmune Hepatitis with Erythema Multiforme. ( 29059460 )
2017
45
Dermoscopy of erythema multiforme. ( 28217488 )
2017
46
Erythema multiforme triggered by Treponema pallidum infection in an HIV-infected patient. ( 28820345 )
2017
47
Erythema multiforme-like cutaneous lesions in monomorphic epitheliotropic intestinal T-cell lymphoma: a rare case report. ( 27862162 )
2017
48
Erythema Multiforme Caused by Treatment With Topical Imiquimod 5% in a Patient With Gorlin Syndrome. ( 29173871 )
2017
49
Pustular erythema multiforme major associated with atypical pneumonia. ( 28543859 )
2017
50
Erythema multiforme induced by regorafenib. ( 29263999 )
2017

Variations for Erythema Multiforme

Expression for Erythema Multiforme

Search GEO for disease gene expression data for Erythema Multiforme.

Pathways for Erythema Multiforme

Pathways related to Erythema Multiforme according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ATF3 CCL17 CXCR3 DSP FASLG IL2
2
Show member pathways
13.51 CCL17 CXCR3 FASLG IFNG IL2 TNF
3
Show member pathways
13.25 CCL17 CXCR3 FASLG IL2 TNF
4
Show member pathways
13.2 FASLG ICAM1 IFNG IL2 TNF
5
Show member pathways
13.14 CCL17 CXCR3 FASLG IL2 TNF
6
Show member pathways
12.67 FASLG GZMB ICAM1 IFNG IL2 TNF
7
Show member pathways
12.63 FASLG ICAM1 IFNG IL2 TNF
8 12.41 FASLG GZMB IFNG IL2 TNF
9 12.31 ATF3 ICAM1 IL2 TNF
10
Show member pathways
12.23 ICAM1 IFNG IL2 TNF
11
Show member pathways
12.2 CCL17 IFNG TNF
12
Show member pathways
12.14 FASLG GZMB TNF
13 12.12 FASLG GZMB TNF
14
Show member pathways
12.11 FASLG GZMB ICAM1 IFNG IL2 TNF
15
Show member pathways
12.08 CCL17 IL2 TNF
16
Show member pathways
12.08 FASLG IFNG TNF
17
Show member pathways
12.06 FASLG IFNG TNF
18 11.97 ICAM1 IFNG TNF
19
Show member pathways
11.94 CCL17 ICAM1 IFNG IL2
20
Show member pathways
11.93 IFNG IL2 TNF
21 11.89 ICAM1 IFNG IL2 TNF
22 11.88 IFNG IL2 TNF
23 11.87 FASLG ICAM1 TNF
24
Show member pathways
11.83 FASLG GZMB IFNG IL2
25 11.75 ICAM1 IFNG TNF
26 11.71 ICAM1 IFNG IL2
27 11.66 IFNG IL2 TNF
28
Show member pathways
11.61 FASLG IFNG IL2 TNF
29 11.56 CCL17 IFNG IL2 TNF
30
Show member pathways
11.47 ICAM1 IFNG IL2 TNF
31 11.46 ICAM1 IFNG TNF
32 11.44 IFNG IL2 TNF
33 11.41 CCL17 IFNG IL2
34 11.4 FASLG IFNG TNF
35 11.38 FASLG ICAM1 IFNG
36 11.33 FASLG IFNG IL2 TNF
37 11.27 ICAM1 IFNG
38 11.26 CXCR3 GZMB IFNG IL2 TNF
39 11.22 IFNG IL2
40 11.2 IFNG TNF
41 11.16 IFNG IL2 TNF
42 11.13 IFNG IL2
43 11.1 IFNG IL2
44 11.1 FASLG ICAM1 IFNG TNF
45 11.08 ICAM1 IFNG
46 11.07 CCL17 FASLG IL2 TNF
47 10.96 ATF3 IFNG
48 10.88 CCL17 FASLG IL2 TNF
49 10.85 ICAM1 TNF
50
Show member pathways
10.81 FASLG GZMB IFNG IL2 TNF

GO Terms for Erythema Multiforme

Cellular components related to Erythema Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.5 FASLG ICAM1 TNF
2 cell surface GO:0009986 9.46 CXCR3 FASLG ICAM1 TNF
3 extracellular space GO:0005615 9.43 CCL17 FASLG ICAM1 IFNG IL2 TNF
4 immunological synapse GO:0001772 9.26 GZMB ICAM1
5 external side of plasma membrane GO:0009897 8.92 CXCR3 FASLG ICAM1 TNF

Biological processes related to Erythema Multiforme according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.9 CXCR3 FASLG GZMB IFNG
2 positive regulation of cell proliferation GO:0008284 9.85 ATF3 FASLG IFNG IL2
3 cell-cell signaling GO:0007267 9.77 CCL17 FASLG IL2
4 cytokine-mediated signaling pathway GO:0019221 9.76 FASLG ICAM1 IL2 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.71 IFNG IL2 TNF
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 FASLG ICAM1
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.58 FASLG TNF
8 negative regulation of myoblast differentiation GO:0045662 9.57 CCL17 TNF
9 positive regulation of protein complex assembly GO:0031334 9.56 IFNG TNF
10 regulation of signaling receptor activity GO:0010469 9.55 CCL17 FASLG IFNG IL2 TNF
11 extrinsic apoptotic signaling pathway GO:0097191 9.54 FASLG IFNG TNF
12 protein import into nucleus, translocation GO:0000060 9.52 IFNG TNF
13 positive regulation of osteoclast differentiation GO:0045672 9.51 IFNG TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 IFNG TNF
15 regulation of regulatory T cell differentiation GO:0045589 9.48 IFNG IL2
16 necroptotic signaling pathway GO:0097527 9.43 FASLG TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 ICAM1 IFNG TNF
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.4 ICAM1 TNF
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
20 immune response GO:0006955 9.1 CCL17 CXCR3 FASLG IFNG IL2 TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF

Molecular functions related to Erythema Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL17 FASLG IFNG IL2 TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 FASLG TNF

Sources for Erythema Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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