EM
MCID: ERY003
MIFTS: 57

Erythema Multiforme (EM)

Categories: Immune diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erythema Multiforme

MalaCards integrated aliases for Erythema Multiforme:

Name: Erythema Multiforme 12 74 52 36 54 43 15 17 71 32
Erythema Polymorphe, Erythema Multiforme Type 52
Dermatostomatitis, Erythema Multiforme Type 52
Herpes Iris, Erythema Multiforme Type 52
Febrile Mucocutaneous Syndrome 52
Erythema Multiforme Bullosum 52
Stevens-Johnson Syndrome 71
Em 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050185
KEGG 36 H01695
MeSH 43 D004892
ICD10 32 L51 L51.9
UMLS 71 C0014742 C0038325

Summaries for Erythema Multiforme

KEGG : 36 Erythema multiforme (EM) is an immune-mediated, mucocutaneous condition characterized by "target" lesions. Classically, EM has been separated into 2 subgroups, EM minor and EM major. In EM minor, lesions often present as papules, which might enlarge and eventually form the typical target lesion with erythema surrounding an area of central clearing. The rash in EM minor preferentially affects the limbs, specifically the extensor surfaces, however, it can also be seen throughout the body, excluding mucous membranes. EM major has mucous membrane involvement. The oral mucosa is most commonly affected, initially with edema that progresses to superficial erosions. Other surfaces that might be involved include the anogenital, ocular, and nasal mucosa. Although previously thought to be on a similar continuum of EM, and histologically appearing the same, Stevens-Johnson syndrome (SJS) is increasingly being considered a separate disease process. It is currently believed that EM is a result of an immune reaction to an inciting infectious or pharmacologic antigen. The most common infectious organisms in EM are herpes simplex virus types 1 and 2, as well as Mycoplasma pneumonia. The first line of treatment for EM is removal of the inciting factor when possible. Systemic steroids have been suggested as adjuvant therapy based on their immunosuppressant effects. To date, their use has been limited to EM major, as EM minor is self-limited.

MalaCards based summary : Erythema Multiforme, also known as erythema polymorphe, erythema multiforme type, is related to severe cutaneous adverse reaction and fixed drug eruption. An important gene associated with Erythema Multiforme is DSP (Desmoplakin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Gabapentin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A skin disease that is a type of allergic reaction located in skin, which occurs in response to medications, infections, or illness.

NIH Rare Diseases : 52 Erythema multiforme (EM) refers to a group of hypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus . In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics . In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).

Wikipedia : 74 Erythema multiforme (EM) is a skin condition of unknown cause; it is a type of erythema possibly... more...

Related Diseases for Erythema Multiforme

Diseases related to Erythema Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 964, show less)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 32.9 TNF GZMB GNLY FASLG FAS
2 fixed drug eruption 30.9 IL2 IFNG
3 pemphigus 30.8 TNF IL4 DSP
4 herpes zoster 30.6 TNF IL2 IFNG
5 exanthem 30.6 TNF IL6 IL2 CXCL8
6 chikungunya 30.3 TNF IL6 CCL5
7 angioedema 30.2 PTGS2 IL6 IL5
8 urticaria 30.2 TNF PTGS2 IL6 IL5 IL4
9 dengue disease 30.1 TNF ICAM1 CCL5
10 kawasaki disease 30.1 TNF IL6 IL4
11 purpura 30.1 TNF IL6 IL4
12 spondylitis 30.0 TNF IL6 IFNG
13 cellulitis 30.0 TNF IL6 IL5 DSP
14 dermatitis herpetiformis 29.9 TNF IL5 IL4 CXCL8
15 non-alcoholic steatohepatitis 29.9 TNF IL6
16 stevens-johnson syndrome/toxic epidermal necrolysis 29.9 IL5 IL2 IFNG FAS CXCR3 CCL5
17 orchitis 29.9 TNF IL6 IL2
18 chlamydia pneumonia 29.9 TNF IL6 CXCL8
19 acute generalized exanthematous pustulosis 29.9 PTGS2 CXCL8
20 alopecia 29.8 TNF IL4 IL2 IFNG DSP
21 haemophilus influenzae 29.8 TNF CXCL8
22 typhoid fever 29.8 TNF IL6 IFNG
23 chickenpox 29.8 TNF IL6 IL4 IL2 IFNG
24 measles 29.8 TNF IL6 IL2 IFNG CCL5
25 soft tissue sarcoma 29.7 TNF IFNG
26 keratitis, hereditary 29.7 TNF IL6 CXCL8
27 tuberculoid leprosy 29.7 IL4 IL2 IFNG
28 neurofibromatosis, type ii 29.7 TNF IL6 CXCL8
29 autoimmune hepatitis 29.6 TNF IL4 FAS
30 diphtheria 29.6 TNF IL5 IL4 IL2 IFNG
31 pharyngitis 29.6 TNF PTGS2 IL6 CXCL8
32 peptic ulcer disease 29.6 TNF PTGS2 CXCL8
33 poliomyelitis 29.6 TNF IL4 IFNG ICAM1
34 chorioretinitis 29.6 TNF IL6 IL2 IFNG
35 cytomegalovirus infection 29.6 TNF IL6 FAS CXCL8 CCL5
36 spinal cord injury 29.5 TNF IL6 CXCL8
37 pertussis 29.5 TNF IL6 CXCL8 CCL5
38 bacterial infectious disease 29.5 TNF IL6 IFNG CXCL8
39 herpangina 29.5 TNF IL6 IL4 IL2
40 cryoglobulinemia 29.5 TNF IL6 IFNG CXCR3
41 localized scleroderma 29.5 TNF IL6 IL4 IL2
42 thymoma 29.5 TNF IL6 IL4 IL2 DSP
43 pulpitis 29.5 TNF IL6 CXCL8
44 systemic scleroderma 29.5 TNF IL6 IL4 IFNG
45 dysentery 29.5 TNF IL6 CXCL8
46 hepatitis b 29.5 TNF IL6 IFNG CXCL8
47 pulmonary edema 29.5 TNF ICAM1 FASLG CXCL8
48 vaccinia 29.5 TNF IL6 IL2 ICAM1 GZMB
49 legionellosis 29.4 TNF IL6 CXCL8
50 bullous pemphigoid 29.4 IL5 IL4 DSP CXCL8 CCL5 CCL17
51 toxic oil syndrome 29.4 IL5 IL4 IFNG
52 acute graft versus host disease 29.3 TNF IL4 IL2 IFNG FASLG
53 human immunodeficiency virus type 1 29.3 TNF IL6 IL2 IFNG CCL5
54 acquired immunodeficiency syndrome 29.3 TNF IL6 IL2 IFNG ICAM1
55 graft-versus-host disease 29.2 TNF IL6 IL2 IFNG GZMB FASLG
56 endophthalmitis 29.2 TNF IL6 ICAM1 CXCL8
57 reactive arthritis 29.2 TNF IL6 IFNG CXCL8
58 sarcoidosis 1 29.1 TNF IL2 IFNG ICAM1 CXCR3 CCL5
59 latex allergy 29.1 TNF IL5 IL4 IFNG
60 bronchiectasis 29.1 TNF IL6 CXCL8
61 yellow fever 29.1 IL6 IL5 IL4 CCL5
62 irritant dermatitis 29.1 TNF IL6 IL4 CXCL8
63 rubella 29.0 TNF IL6 IL5 IL4 IL2 IFNG
64 folliculitis 29.0 IL5 IL4 IFNG GNLY CCL5
65 mycosis fungoides 29.0 IL5 IL2 IFNG GZMB CXCR3 CCL17
66 gout 29.0 TNF IL6 CXCL8
67 vascular disease 29.0 TNF PTGS2 IL6 IL2 IFNG ICAM1
68 fibromyalgia 29.0 TNF IL6 IL2 CXCL8
69 relapsing polychondritis 29.0 IL6 IL2 IFNG CXCL8
70 pericarditis 29.0 TNF IL6 IFNG CXCL8
71 bacterial meningitis 28.9 TNF IL6 IFNG CXCL8
72 mumps 28.9 TNF IL6 IL2 IFNG CXCL8
73 pulmonary tuberculosis 28.9 TNF IL6 IL4 IL2 IFNG
74 psoriatic arthritis 28.9 TNF IL6 IL4 IL2 IFNG
75 lepromatous leprosy 28.9 TNF IL4 IL2 IFNG ICAM1 CCL17
76 fatty liver disease 28.9 TNF IL6 FAS CXCL8
77 synovitis 28.9 TNF IL6 ICAM1 CXCL8
78 drug-induced lupus erythematosus 28.9 TNF IL6 IL4 CXCL8
79 cholera 28.8 TNF IL6 IL4 CXCL8
80 orofacial granulomatosis 28.8 TNF IL4 IFNG CXCR3 CCL5
81 mastitis 28.8 IL6 ICAM1 CXCL8 CCL5
82 leukemia, chronic lymphocytic 28.8 TNF IL6 IL4 IL2 FAS CXCR3
83 stomatitis 28.8 TNF IL6 IL4 IL2 IFNG CXCL8
84 influenza 28.8 TNF IL6 IFNG CXCL8 CCL5
85 acute promyelocytic leukemia 28.8 TNF IL6 ICAM1 FAS CXCL8
86 tetanus 28.7 TNF IL6 IL5 IL4 IL2 IFNG
87 cutaneous lupus erythematosus 28.7 TNF IL6 IFNG ICAM1 GZMB CXCR3
88 lymphopenia 28.7 IL6 IL4 IL2 IFNG FASLG FAS
89 endometriosis 28.7 PTGS2 IL6 CXCL8 CCL5
90 hemophagocytic lymphohistiocytosis 28.7 TNF IFNG GZMB GNLY CXCL8
91 diarrhea 28.7 TNF IL6 IL5 IL2 IFNG CXCL8
92 chlamydia 28.6 TNF IL6 IL4 IFNG CXCL8
93 toxoplasmosis 28.6 TNF IL6 IL5 IL4 IFNG
94 paracoccidioidomycosis 28.6 TNF IL6 IL5 IL4 IL2 IFNG
95 renal cell carcinoma, nonpapillary 28.6 IL4 IL2 IFNG ICAM1 FASLG FAS
96 idiopathic interstitial pneumonia 28.6 IL4 IFNG ICAM1 CXCL8
97 cataract 28.5 TNF PTGS2 IL6 IL2 ICAM1 CXCL8
98 hypereosinophilic syndrome 28.5 IL5 IL4 IL2 IFNG CXCL8 CCL5
99 smallpox 28.5 TNF IL4 IL2 IFNG ICAM1 GZMB
100 immune deficiency disease 28.5 TNF IL6 IL4 IL2 IFNG FASLG
101 severe acute respiratory syndrome 28.5 TNF IL6 IL2 IFNG CXCL8 CCL5
102 pulmonary fibrosis, idiopathic 28.4 TNF IL6 IL5 IL4 IFNG FASLG
103 myocarditis 28.4 TNF IL6 IL4 IL2 IFNG ICAM1
104 crohn's disease 28.4 TNF IL6 IL4 IL2 IFNG CXCL8
105 colitis 28.3 TNF PTGS2 IL6 IL4 IL2 IFNG
106 basal cell carcinoma 28.3 TNF PTGS2 IL6 IL2 ICAM1 FASLG
107 ulcerative colitis 28.3 TNF IL6 IL4 IL2 IFNG ICAM1
108 tonsillitis 28.3 TNF IL6 IL4 IL2 IFNG CXCL8
109 candidiasis 28.2 TNF IL6 IL4 IL2 IFNG CXCL8
110 allergic hypersensitivity disease 28.2 TNF IL5 IL4 IL2 IFNG ICAM1
111 bronchitis 28.2 TNF IL6 IL5 IL4 CXCL8 CCL5
112 sarcoma 28.2 PTGS2 IL6 ICAM1 FAS CXCL8 CCL5
113 respiratory failure 28.2 TNF IL6 IL5 CXCL8 CCL5 CCL17
114 lymphadenitis 28.1 TNF IFNG ICAM1 FASLG FAS CXCR3
115 conjunctivitis 28.1 TNF IL6 IL5 IL4 IL2 IFNG
116 leptospirosis 28.1 TNF IL6 IL4 IL2 IFNG CXCL8
117 toxic shock syndrome 28.1 TNF IL6 IL4 IL2 IFNG CXCL8
118 conjunctival disease 28.0 TNF IL6 IL5 IL4 IL2 CXCL8
119 osteomyelitis 28.0 TNF IL6 IL4 IFNG CXCL8 CCL5
120 gastroenteritis 28.0 TNF IL6 IL5 IL4 IFNG CXCL8
121 gastroesophageal reflux 28.0 TNF PTGS2 IL6 IL5 IL4 CXCL8
122 leprosy 3 28.0 TNF IL6 IL5 IL4 IL2 IFNG
123 viral hepatitis 28.0 TNF IL6 IL4 IL2 IFNG FASLG
124 dengue hemorrhagic fever 28.0 TNF IL6 IL4 IFNG CXCL8
125 arthritis 27.9 TNF PTGS2 IL6 IL4 IFNG ICAM1
126 glioblastoma multiforme 27.8 TNF PTGS2 IL6 IL2 IFNG ICAM1
127 aphthous stomatitis 27.8 TNF IL6 IL5 IL4 IL2 IFNG
128 upper respiratory tract disease 27.8 TNF IL6 IL5 IL4 IL2 IFNG
129 body mass index quantitative trait locus 11 27.8 TNF PTGS2 IL6 IL4 ICAM1 CXCL8
130 chagas disease 27.7 TNF IL6 IL4 IL2 IFNG CXCL8
131 contact dermatitis 27.7 TNF IL6 IL5 IL4 IL2 IFNG
132 otitis media 27.7 TNF IL6 IL5 IL4 IFNG ICAM1
133 common cold 27.6 TNF IL6 IL5 IL4 ICAM1 CXCL8
134 allergic contact dermatitis 27.6 TNF IL6 IL5 IL4 IFNG ICAM1
135 cervical cancer 27.6 TNF PTGS2 IL6 IL2 IFNG FASLG
136 lichen planus 27.5 TNF IL6 IL4 IL2 IFNG ICAM1
137 alopecia areata 27.4 TNF IL6 IL4 IL2 IFNG ICAM1
138 chronic fatigue syndrome 27.4 TNF IL6 IL5 IL4 IL2 IFNG
139 bronchiolitis 27.4 TNF IL6 IL5 IL4 IFNG CXCL8
140 gingivitis 27.4 TNF IL6 IL4 IL2 IFNG ICAM1
141 dermatitis 27.4 TNF IL6 IL5 IL4 IL2 IFNG
142 allergic asthma 27.4 IL5 IL4 IFNG ICAM1 CXCL8 CCL5
143 aplastic anemia 27.3 TNF IL6 IL4 IL2 IFNG FASLG
144 keratoconjunctivitis 27.3 TNF IL6 IL5 IL4 IL2 IFNG
145 peritonitis 27.3 TNF IL6 IL4 IFNG ICAM1 CXCL8
146 myocardial infarction 27.3 TNF PTGS2 IL6 IL4 IFNG ICAM1
147 pneumonia 27.3 TNF IL6 IL5 IL4 IL2 IFNG
148 pulmonary disease, chronic obstructive 27.2 TNF IL6 IL5 IL4 GZMB CXCR3
149 hepatocellular carcinoma 27.1 TNF PTGS2 IL6 IL2 ICAM1 FASLG
150 meningitis 27.1 TNF IL6 IL5 IL4 IL2 IFNG
151 skin disease 27.1 TNF IL6 IL5 IL4 IL2 IFNG
152 proteasome-associated autoinflammatory syndrome 1 27.1 TNF PTGS2 IL6 IL5 IL4 IFNG
153 rhinitis 27.1 TNF IL6 IL5 IL4 IFNG ICAM1
154 myeloma, multiple 27.0 TNF IL6 IL4 IL2 IFNG ICAM1
155 thrombocytopenia 27.0 TNF IL6 IL4 IL2 IFNG ICAM1
156 autoimmune disease 26.7 TNF IL6 IL5 IL4 IL2 IFNG
157 lung disease 26.7 TNF IL6 IL5 IL4 IFNG ICAM1
158 osteoporosis 26.7 TNF PTGS2 IL6 IL4 IL2 IFNG
159 psoriasis 26.7 TNF IL6 IL5 IL4 IL2 IFNG
160 interstitial lung disease 26.6 TNF IL6 IL5 IL4 IFNG ICAM1
161 systemic lupus erythematosus 26.5 TNF IL6 IL5 IL4 IL2 IFNG
162 dermatitis, atopic 26.0 TNF IL6 IL5 IL4 IL2 IFNG
163 trypanosomiasis 25.8 TNF IL6 IL4 IL2 IFNG ICAM1
164 inflammatory bowel disease 25.6 TNF PTGS2 IL6 IL5 IL4 IL2
165 malaria 25.2 TNF PTGS2 IL6 IL5 IL4 IL2
166 asthma 24.6 TNF IL6 IL5 IL4 IL2 IFNG
167 erythema multiforme major 12.7
168 eosinophilia-myalgia syndrome 12.2
169 early myoclonic encephalopathy 11.8
170 epileptic encephalopathy, early infantile, 3 11.5
171 erythromelalgia 11.4
172 pseudomembranous conjunctivitis 11.4
173 pulmonary embolism 11.3
174 encephalopathy, ethylmalonic 11.2
175 epileptic encephalopathy, early infantile, 4 11.2
176 alpha-1-antitrypsin deficiency 11.2
177 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 11.0
178 herpes simplex 11.0
179 cardiac arrest 10.6
180 lupus erythematosus 10.6
181 aztreonam allergy 10.5 IL5 IL2
182 kashin-beck disease 10.5 TNF FAS
183 respiratory syncytial virus infectious disease 10.4 IL5 CCL5
184 dermatitis herpetiformis, familial 10.4
185 cefuroxime allergy 10.4 PTGS2 IL5
186 type ii mixed cryoglobulinemia 10.4 FASLG FAS
187 external pathological resorption 10.4 TNF IL6
188 syphilis 10.4
189 hepatitis 10.4
190 palladium allergic contact dermatitis 10.4 TNF CCL17
191 ventricular fibrillation, paroxysmal familial, 1 10.3
192 bullous skin disease 10.3 IL5 DSP CCL5
193 mucositis 10.3
194 neutropenia 10.3
195 eosinophilic fasciitis 10.3 IL5 IFNG
196 hepatitis c virus 10.3
197 secondary syphilis 10.3
198 pustulosis of palm and sole 10.3
199 polyarticular juvenile idiopathic arthritis 10.3 TNF IFNG
200 staphylococcal toxic shock syndrome 10.3 TNF IFNG
201 epstein-barr virus-associated gastric carcinoma 10.3 TNF FASLG FAS
202 autoimmune myocarditis 10.3 TNF IFNG
203 uremic pruritus 10.3 IL6 IL2
204 obesity-hypoventilation syndrome 10.3 IL6 CCL5
205 helix syndrome 10.3
206 drug allergy 10.3
207 histoplasmosis 10.3
208 dermatophytosis 10.3
209 hansen's disease 10.3
210 actinic prurigo 10.3 TNF ICAM1
211 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.3 IL4 IL2
212 tropical endomyocardial fibrosis 10.3 TNF IL4
213 null-cell leukemia 10.3 TNF IL6
214 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6 IL5
215 scleral disease 10.2 TNF IL6 IL2
216 autoimmune disease of cardiovascular system 10.2 TNF IL6 IL2
217 vasculitis 10.2
218 subacute cutaneous lupus erythematosus 10.2
219 chronic beryllium disease 10.2 TNF IFNG
220 scorpion envenomation 10.2 TNF IL6 CCL5
221 erysipelas 10.2 TNF IL6 IL2
222 burning mouth syndrome 10.2 TNF IL6 IL2
223 poems syndrome 10.2 TNF IL6 IL2
224 persistent polyclonal b-cell lymphocytosis 10.2 IL4 FAS
225 ocular motor apraxia 10.2
226 virus associated hemophagocytic syndrome 10.2 IL4 IL2
227 posterior urethral valves 10.2 TNF IL6
228 penile disease 10.2 TNF IL6 IL2
229 listeriosis 10.2 TNF IL6 IL2
230 stachybotrys chartarum 10.2 TNF IL6 CCL5
231 anaerobic pneumonia 10.2 IL6 CCL5
232 lymphocytic gastritis 10.2 GZMB FASLG FAS
233 lymphoid interstitial pneumonia 10.2 TNF IL6 IL2
234 spinal cord disease 10.2 TNF IL6 IL2
235 pfeiffer syndrome 10.2
236 pemphigus vulgaris, familial 10.2
237 hepatitis c 10.2
238 autoimmune progesterone dermatitis 10.2
239 adult t-cell leukemia 10.2 IL2 ICAM1 FAS
240 t-cell large granular lymphocyte leukemia 10.2 IL2 GZMB FASLG
241 pustulosis palmaris et plantaris 10.2 TNF IL5 CXCR3
242 rheumatoid vasculitis 10.2 TNF ICAM1
243 spotted fever 10.2 TNF IFNG CCL5
244 spotted fever rickettsiosis 10.2 TNF IFNG CCL5
245 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
246 meningoencephalitis 10.2 TNF IL6 CCL5
247 ileitis 10.2 TNF IL6 CCL5
248 jak3-deficient severe combined immunodeficiency 10.2 IL4 IL2
249 bipolar i disorder 10.1
250 substance abuse 10.1
251 vein disease 10.1 TNF IL6 ICAM1
252 blood coagulation disease 10.1 TNF IL6 IL2
253 hantavirus hemorrhagic fever with renal syndrome 10.1 TNF IL6 GZMB
254 nodular goiter 10.1 IL6 ICAM1 FAS
255 dowling-degos disease 1 10.1
256 lung cancer 10.1
257 yemenite deaf-blind hypopigmentation syndrome 10.1
258 pemphigus gestationis 10.1
259 variola major 10.1
260 rabies 10.1
261 cicatricial pemphigoid 10.1
262 pemphigoid gestationis 10.1
263 granuloma annulare 10.1
264 mouth disease 10.1
265 genital herpes 10.1
266 pityriasis rosea 10.1
267 ritter's disease 10.1
268 48,xyyy 10.1
269 chronic graft versus host disease 10.1
270 drug reaction with eosinophilia and systemic symptoms 10.1
271 exfoliative dermatitis 10.1
272 linear iga disease 10.1
273 paraneoplastic pemphigus 10.1
274 limb ischemia 10.1 TNF IL6 ICAM1
275 autoimmune vasculitis 10.1 TNF IL4 IL2
276 acute myocarditis 10.1 IL6 FASLG FAS
277 endomyocardial fibrosis 10.1 TNF IL5 IL4
278 peripheral artery disease 10.1 TNF IL6 ICAM1
279 syncope 10.1
280 rapidly involuting congenital hemangioma 10.1
281 toxic encephalopathy 10.1 TNF PTGS2 IL6
282 cow milk allergy 10.1 TNF IL5 IL4
283 milk allergy 10.1 TNF IL5 IL4
284 angiostrongyliasis 10.1 IL5 IL4 IL2
285 eosinophilic meningitis 10.1 IL5 IL4 IL2
286 fabry disease 10.1 TNF IL6 ICAM1
287 acrocallosal syndrome 10.1
288 ischemia 10.1
289 kidney disease 10.1
290 oral lichen planus 10.1 ICAM1 CXCR3 CCL5
291 vernal keratoconjunctivitis 10.1 IL5 IL4 CCL5
292 sickle cell anemia 10.1 TNF IL6 ICAM1
293 lymphomatoid papulosis 10.1 GZMB FAS
294 kimura disease 10.1 IL5 IL4 CCL5
295 paragonimiasis 10.0 IL5 CXCR3 CCL17
296 spondyloarthropathy 1 10.0
297 breast cancer 10.0
298 colorectal cancer 10.0
299 cryoglobulinemia, familial mixed 10.0
300 ocular cicatricial pemphigoid 10.0
301 porphyria cutanea tarda 10.0
302 small cell cancer of the lung 10.0
303 thymoma, familial 10.0
304 nail disorder, nonsyndromic congenital, 10 10.0
305 deficiency anemia 10.0
306 lymphoma 10.0
307 lymphocytic leukemia 10.0
308 ornithosis 10.0
309 heart disease 10.0
310 lyme disease 10.0
311 nephrotic syndrome 10.0
312 ecthyma 10.0
313 inflammatory spondylopathy 10.0
314 entropion 10.0
315 porphyria 10.0
316 keratosis 10.0
317 melanoma 10.0
318 congestive heart failure 10.0
319 contagious pustular dermatitis 10.0
320 molluscum contagiosum 10.0
321 47,xyy 10.0
322 cutaneous larva migrans 10.0
323 kikuchi disease 10.0
324 perniosis 10.0
325 depression 10.0
326 headache 10.0
327 stevens-johnson syndrome/toxic epidermal necrolysis overlap syndrome 10.0
328 colorectal adenoma 10.0 TNF PTGS2 IL6
329 ataxia and polyneuropathy, adult-onset 10.0
330 encephalitis 10.0
331 traumatic brain injury 10.0
332 pik3ca-related overgrowth syndrome 10.0
333 intracranial berry aneurysm 10.0 TNF IL6 ICAM1
334 leukoregulin 10.0 PTGS2 CXCL8
335 lung abscess 10.0 TNF IL6 IFNG
336 esophagus melanoma 10.0 FAS CXCL8
337 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 GZMB FASLG CCL5
338 fungal meningitis 10.0 TNF IL6 IFNG
339 central nervous system vasculitis 10.0 TNF IL6 IFNG
340 childhood type dermatomyositis 10.0 TNF IL6 CXCR3
341 vascular dementia 10.0 TNF IL6 ICAM1
342 cardiac conduction defect 10.0
343 hair whorl 10.0
344 moyamoya disease 1 10.0
345 dengue virus 10.0
346 cerebrovascular disease 10.0
347 chronic kidney disease 10.0
348 subacute delirium 10.0
349 amyloidosis 10.0
350 muscular dystrophy 10.0
351 brain injury 10.0
352 multicentric castleman disease 10.0 IL6 IL5 IFNG
353 oral tuberculosis 10.0 TNF IL2 IFNG GNLY
354 primary progressive multiple sclerosis 10.0 TNF IL4 ICAM1
355 mixed connective tissue disease 10.0 TNF IL6 IFNG
356 idiopathic neutropenia 10.0 TNF IL6 FASLG CCL5
357 melioidosis 10.0 TNF IL6 IFNG
358 wells syndrome 9.9 IL5 IL2 CXCL8
359 salmonellosis 9.9 TNF IL6 IFNG
360 inguinal hernia 9.9 PTGS2 IL6 ICAM1
361 gastrointestinal tuberculosis 9.9 TNF IFNG
362 ataxia-telangiectasia 9.9
363 helicobacter pylori infection 9.9
364 stroke, ischemic 9.9
365 plague 9.9
366 acute myocardial infarction 9.9
367 hypoglycemia 9.9
368 hypertrophic cardiomyopathy 9.9
369 back pain 9.9
370 encephalopathy 9.9
371 head injury 9.9
372 trachoma 9.9 TNF IL6 IL4
373 onchocerciasis 9.9 IL5 IL4 IL2 CCL5
374 rheumatic heart disease 9.9 TNF IL6 IL4
375 mycobacterium abscessus 9.9 TNF CXCL8
376 nickel allergic contact dermatitis 9.9 IL5 IL4 IFNG
377 combined t cell and b cell immunodeficiency 9.9 IL6 IL4 IL2
378 acute transverse myelitis 9.9 IL6 CXCL8
379 status asthmaticus 9.9 IL5 CXCL8 CCL5
380 annular erythema 9.9
381 major affective disorder 1 9.9
382 myoclonus and ataxia 9.9
383 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
384 meningioma, radiation-induced 9.9
385 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
386 meningioma, familial 9.9
387 major depressive disorder 9.9
388 legionnaire disease 9.9
389 major affective disorder 8 9.9
390 major affective disorder 9 9.9
391 psoriasis 14, pustular 9.9
392 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
393 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
394 cholangiocarcinoma 9.9
395 hydrops, lactic acidosis, and sideroblastic anemia 9.9
396 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
397 swine influenza 9.9
398 early congenital syphilis 9.9
399 peripheral t-cell lymphoma 9.9
400 glucocorticoid-induced osteoporosis 9.9
401 erythema elevatum diutinum 9.9
402 angioimmunoblastic t-cell lymphoma 9.9
403 dermatomyositis 9.9
404 parotitis 9.9
405 hand, foot and mouth disease 9.9
406 borderline personality disorder 9.9
407 anogenital venereal wart 9.9
408 t cell deficiency 9.9
409 disseminated intravascular coagulation 9.9
410 spinal meningioma 9.9
411 myopia 9.9
412 tinea corporis 9.9
413 punctate epithelial keratoconjunctivitis 9.9
414 locked-in syndrome 9.9
415 telangiectasis 9.9
416 quadriplegia 9.9
417 keratoconjunctivitis sicca 9.9
418 balanitis 9.9
419 tinea unguium 9.9
420 myringitis bullosa hemorrhagica 9.9
421 facial paralysis 9.9
422 amenorrhea 9.9
423 oral candidiasis 9.9
424 sporotrichosis 9.9
425 personality disorder 9.9
426 dermatomycosis 9.9
427 rheumatic disease 9.9
428 thrombocytopenia due to platelet alloimmunization 9.9
429 mental depression 9.9
430 ichthyosis 9.9
431 cholecystitis 9.9
432 rectum cancer 9.9
433 giant cell tumor 9.9
434 enthesopathy 9.9
435 tularemia 9.9
436 focal epilepsy 9.9
437 macrocytic anemia 9.9
438 acromegaly 9.9
439 agammaglobulinemia 9.9
440 epidermolysis bullosa 9.9
441 bilirubin metabolic disorder 9.9
442 newcastle disease 9.9
443 antiphospholipid syndrome 9.9
444 lipid metabolism disorder 9.9
445 neurodermatitis 9.9
446 bipolar disorder 9.9
447 mastocytosis 9.9
448 hypertrichosis 9.9
449 superficial basal cell carcinoma 9.9
450 spongiotic dermatitis 9.9
451 secretory meningioma 9.9
452 lymphoplasmacyte-rich meningioma 9.9
453 intrahepatic cholangiocarcinoma 9.9
454 pancreatitis 9.9
455 sleep disorder 9.9
456 hemolytic anemia 9.9
457 esophageal disease 9.9
458 anal canal squamous cell carcinoma 9.9
459 cutaneous anthrax 9.9
460 anthrax disease 9.9
461 epilepsy with generalized tonic-clonic seizures 9.9
462 hyperthyroidism 9.9
463 impetigo 9.9
464 herpetic whitlow 9.9
465 milker's nodule 9.9
466 seborrheic dermatitis 9.9
467 actinic keratosis 9.9
468 eczema herpeticum 9.9
469 hard palate cancer 9.9
470 lymphangitis 9.9
471 ulcerative stomatitis 9.9
472 hypersensitivity vasculitis 9.9
473 congenital syphilis 9.9
474 acute articular rheumatism 9.9
475 enteropathy-associated t-cell lymphoma 9.9
476 neisseria meningitidis infection 9.9
477 neonatal herpes 9.9
478 pemphigus foliaceus 9.9
479 pustular psoriasis 9.9
480 splenomegaly 9.9
481 tremor 9.9
482 systemic autoimmune disease 9.9
483 glial tumor 9.9
484 bullous impetigo 9.9
485 acute liver failure 9.9
486 corticosteroid allergy 9.9 IL5 IL4 IFNG
487 herpes simplex virus keratitis 9.9 ICAM1 CXCL8
488 neuromyelitis optica 9.9 IL6 IL5 IL4
489 cryptococcosis 9.9 TNF IL4 IFNG
490 brain edema 9.9 IL6 IL2 IFNG
491 urinary schistosomiasis 9.9 IL5 IL4 IFNG
492 collagen disease 9.9 TNF IL6 IL4
493 autoimmune lymphoproliferative syndrome 9.9 TNF IL2 GZMB FASLG FAS
494 vulvovaginal candidiasis 9.9 IL4 IL2 IFNG
495 carotid stenosis 9.9 TNF ICAM1 CXCL8
496 ige responsiveness, atopic 9.9 IL5 IL4 IFNG
497 angelucci's syndrome 9.9 IFNG CXCL8
498 arthropathy 9.8 TNF PTGS2 IL6 IFNG
499 end stage renal failure 9.8 TNF PTGS2 IL6 IL2 CCL5
500 alcohol dependence 9.8
501 alzheimer disease 9.8
502 cerebral amyloid angiopathy, cst3-related 9.8
503 papillomatosis, confluent and reticulated 9.8
504 polykaryocytosis inducer 9.8
505 triiodothyronine receptor auxiliary protein 9.8
506 chondrosarcoma 9.8
507 sudden infant death syndrome 9.8
508 oliver-mcfarlane syndrome 9.8
509 tarp syndrome 9.8
510 body mass index quantitative trait locus 9 9.8
511 astigmatism 9.8
512 body mass index quantitative trait locus 8 9.8
513 panbronchiolitis, diffuse 9.8
514 body mass index quantitative trait locus 1 9.8
515 gastrointestinal stromal tumor 9.8
516 body mass index quantitative trait locus 4 9.8
517 body mass index quantitative trait locus 10 9.8
518 anxiety 9.8
519 endometrial cancer 9.8
520 body mass index quantitative trait locus 7 9.8
521 buruli ulcer 9.8
522 body mass index quantitative trait locus 12 9.8
523 body mass index quantitative trait locus 14 9.8
524 leptin deficiency or dysfunction 9.8
525 body mass index quantitative trait locus 18 9.8
526 body mass index quantitative trait locus 19 9.8
527 body mass index quantitative trait locus 20 9.8
528 early infantile epileptic encephalopathy 9.8
529 polycystic kidney disease 9.8
530 depersonalization disorder 9.8
531 disease of mental health 9.8
532 status epilepticus 9.8
533 hyperinsulinism 9.8
534 long qt syndrome 9.8
535 pulmonary fibrosis 9.8
536 erythrasma 9.8
537 ebola hemorrhagic fever 9.8
538 b-cell lymphoma 9.8
539 gas gangrene 9.8
540 venezuelan equine encephalitis 9.8
541 al amyloidosis 9.8
542 carcinoma showing thymus-like differentiation 9.8
543 cytokine deficiency 9.8
544 dwarfism 9.8
545 glioma 9.8
546 meningococcemia 9.8
547 chronic pain 9.8
548 fainting 9.8
549 myoclonus 9.8
550 ohtahara syndrome 9.8
551 african tick-bite fever 9.8 TNF IL6 IFNG CCL5
552 myelitis 9.8 TNF IL6 CXCL8
553 takayasu arteritis 9.8 TNF IL6 IL2 ICAM1 CCL5
554 fuchs' heterochromic uveitis 9.8 IL6 CXCL8
555 temporal arteritis 9.8 TNF IL6 IFNG CCL5
556 panniculitis 9.8 IFNG GZMB FASLG FAS
557 idiopathic anterior uveitis 9.8 TNF IL6 CXCL8
558 ileus 9.8 TNF IL6 IFNG ICAM1
559 transverse myelitis 9.8 TNF IL6 CXCL8
560 autoimmune disease of eyes, ear, nose and throat 9.8 TNF IL6 IL4 IL2
561 plasmacytoma 9.8 IL6 IL4 IL2
562 periapical periodontitis 9.8 TNF IL6 CXCL8
563 dental pulp disease 9.8 TNF IL6 CXCL8
564 urethritis 9.8 TNF IL6 CXCL8
565 blood group, globoside system 9.8 TNF IL6 CXCL8
566 vitreous disease 9.8 TNF IL6 CXCL8
567 cecal disease 9.8 TNF IL6 CXCL8
568 cervicitis 9.8 IL6 IL2 CXCL8
569 bronchopneumonia 9.8 TNF IL6 CXCL8
570 fallopian tube disease 9.8 TNF IL6 CXCL8
571 pyelitis 9.8 TNF IL6 CXCL8
572 toxicodendron dermatitis 9.8 TNF IL2 ICAM1 CXCL8
573 gingival disease 9.8 TNF IL6 CXCL8
574 capillary leak syndrome 9.8 IL6 IL2 CXCL8
575 perinatal necrotizing enterocolitis 9.8 TNF IL6 CXCL8
576 necrotizing fasciitis 9.8 IL6 IL2 CXCL8
577 adult-onset still's disease 9.8 TNF IL6 CXCL8
578 endometritis 9.8 TNF IL6 CXCL8
579 sebaceous gland disease 9.8 TNF IL6 CXCL8
580 rosacea 9.8 TNF IL6 CXCL8
581 endocardium disease 9.8 TNF IL6 CXCL8
582 middle ear disease 9.8 TNF IL6 CXCL8
583 apnea, obstructive sleep 9.8 TNF IL6 CXCL8
584 peptic esophagitis 9.8 PTGS2 IL6 CXCL8
585 bacterial sepsis 9.8 TNF IL6 CXCL8
586 leukemia, acute monocytic 9.8 TNF IL6 CXCL8
587 mucocutaneous leishmaniasis 9.8 TNF IL4 IL2 IFNG
588 preterm premature rupture of the membranes 9.8 TNF IL6 CXCL8
589 retinal vein occlusion 9.7 TNF IL6 CXCL8
590 acute cystitis 9.7 TNF IL6 CXCL8
591 interstitial cystitis 9.7 IL6 IL2 CXCL8
592 pulmonary alveolar proteinosis 9.7 TNF IL6 CXCL8
593 atopic keratoconjunctivitis 9.7 IL5 IL4 IL2 IFNG
594 scleritis 9.7 TNF IL5 IL4 IFNG
595 b-cell growth factor 9.7 IL6 IL4 IFNG
596 hepatitis a 9.7 TNF IL4 IL2 IFNG
597 cyclic neutropenia 9.7 TNF IFNG CXCL8
598 myasthenia gravis 9.7 TNF IL4 IL2 IFNG
599 duodenal ulcer 9.7 TNF IL6 CXCL8
600 aseptic meningitis 9.7 TNF IFNG CXCL8
601 omenn syndrome 9.7 TNF IL5 IL4 IFNG
602 cone-rod dystrophy 2 9.7 TNF IL6 IL2 FASLG FAS
603 alcoholic liver cirrhosis 9.7 TNF IL6 CXCL8
604 bacterial pneumonia 9.7 TNF IL6 CXCL8
605 aortic aneurysm, familial abdominal, 1 9.7
606 amyotrophic lateral sclerosis 1 9.7
607 atrial standstill 1 9.7
608 bladder cancer 9.7
609 carcinoid tumors, intestinal 9.7
610 cardiac arrhythmia 9.7
611 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.7
612 hand skill, relative 9.7
613 hypercholesterolemia, familial, 1 9.7
614 kaposi sarcoma 9.7
615 marfan syndrome 9.7
616 motion sickness 9.7
617 pick disease of brain 9.7
618 prostate cancer 9.7
619 thyroid cancer, nonmedullary, 1 9.7
620 cerebrotendinous xanthomatosis 9.7
621 chordoma 9.7
622 cystic fibrosis 9.7
623 epidermodysplasia verruciformis 1 9.7
624 hemochromatosis, type 1 9.7
625 mucolipidosis iv 9.7
626 ullrich congenital muscular dystrophy 1 9.7
627 osteogenic sarcoma 9.7
628 retinitis pigmentosa 9.7
629 peeling skin syndrome 1 9.7
630 sarcoma, synovial 9.7
631 retinoschisis 1, x-linked, juvenile 9.7
632 xanthomatosis 9.7
633 branchiootic syndrome 1 9.7
634 macular degeneration, age-related, 1 9.7
635 light fixation seizure syndrome 9.7
636 diamond-blackfan anemia 2 9.7
637 nasopharyngeal carcinoma 9.7
638 dermatofibrosarcoma protuberans 9.7
639 mitochondrial trifunctional protein deficiency 9.7
640 hyperinsulinemic hypoglycemia, familial, 5 9.7
641 hyperinsulinemic hypoglycemia, familial, 4 9.7
642 west nile virus 9.7
643 hamamy syndrome 9.7
644 bone mineral density quantitative trait locus 8 9.7
645 ewing sarcoma 9.7
646 diabetes mellitus, ketosis-prone 9.7
647 chondrosarcoma, extraskeletal myxoid 9.7
648 polycystic kidney disease 2 with or without polycystic liver disease 9.7
649 muscular dystrophy, congenital, lmna-related 9.7
650 bone mineral density quantitative trait locus 15 9.7
651 chromosome 8p11 myeloproliferative syndrome 9.7
652 fanconi anemia, complementation group l 9.7
653 cortical malformations, occipital 9.7
654 membranous nephropathy 9.7
655 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.7
656 aortic valve disease 2 9.7
657 chorea, childhood-onset, with psychomotor retardation 9.7
658 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.7
659 west syndrome 9.7
660 angiosarcoma 9.7
661 acute diarrhea 9.7
662 aspiration pneumonia 9.7
663 diffuse large b-cell lymphoma 9.7
664 atrioventricular block 9.7
665 salivary gland carcinoma 9.7
666 mucosal melanoma 9.7
667 pain agnosia 9.7
668 ischemic colitis 9.7
669 atrial fibrillation 9.7
670 stuttering 9.7
671 oral hairy leukoplakia 9.7
672 ectopic pregnancy 9.7
673 physical disorder 9.7
674 meningococcal meningitis 9.7
675 mucolipidosis 9.7
676 thyroid gland anaplastic carcinoma 9.7
677 sensorineural hearing loss 9.7
678 neuroretinitis 9.7
679 ehrlichiosis 9.7
680 pneumonic plague 9.7
681 lactose intolerance 9.7
682 giardiasis 9.7
683 eastern equine encephalitis 9.7
684 japanese encephalitis 9.7
685 opioid abuse 9.7
686 horner's syndrome 9.7
687 dental pulp necrosis 9.7
688 visual epilepsy 9.7
689 goiter 9.7
690 leukemia 9.7
691 acute leukemia 9.7
692 choreatic disease 9.7
693 vertebrobasilar insufficiency 9.7
694 dementia 9.7
695 focal segmental glomerulosclerosis 9.7
696 rift valley fever 9.7
697 coccidioidomycosis 9.7
698 dental fluorosis 9.7
699 neuroleptic malignant syndrome 9.7
700 dumping syndrome 9.7
701 root resorption 9.7
702 benign familial neonatal epilepsy 9.7
703 endogenous depression 9.7
704 pneumothorax 9.7
705 neuroendocrine tumor 9.7
706 impotence 9.7
707 leiomyosarcoma 9.7
708 connective tissue cancer 9.7
709 post-traumatic stress disorder 9.7
710 dental caries 9.7
711 hemorrhagic disease 9.7
712 transient cerebral ischemia 9.7
713 lateral sclerosis 9.7
714 iron metabolism disease 9.7
715 glomerulonephritis 9.7
716 adenocarcinoma 9.7
717 nemaline myopathy 9.7
718 tracheal stenosis 9.7
719 rhabdomyosarcoma 9.7
720 fibrosarcoma 9.7
721 liposarcoma 9.7
722 retinitis 9.7
723 aortic aneurysm 9.7
724 lactic acidosis 9.7
725 thyroid gland papillary carcinoma 9.7
726 eosinophilic gastroenteritis 9.7
727 hyperglycemia 9.7
728 myopathy 9.7
729 spindle cell sarcoma 9.7
730 hepatitis e 9.7
731 clear cell renal cell carcinoma 9.7
732 sarcomatoid renal cell carcinoma 9.7
733 extraosseous chondrosarcoma 9.7
734 atrophic rhinitis 9.7
735 subependymal giant cell astrocytoma 9.7
736 liver cirrhosis 9.7
737 aortic disease 9.7
738 myxoid chondrosarcoma 9.7
739 acute stress disorder 9.7
740 mitochondrial metabolism disease 9.7
741 intestinal obstruction 9.7
742 oropharynx cancer 9.7
743 in situ carcinoma 9.7
744 learning disability 9.7
745 cervix uteri carcinoma in situ 9.7
746 ocular hypertension 9.7
747 epiglottitis 9.7
748 lipid storage disease 9.7
749 primary ciliary dyskinesia 9.7
750 hemophilia 9.7
751 collagen type vi-related disorders 9.7
752 hereditary transthyretin amyloidosis 9.7
753 mitochondrial disorders 9.7
754 amyloidosis aa 9.7
755 bronchopulmonary dysplasia 9.7
756 cervical intraepithelial neoplasia 9.7
757 gangliosidosis 9.7
758 leukoplakia 9.7
759 mycobacterium marinum 9.7
760 periodontal ehlers-danlos syndrome 9.7
761 reversible cerebral vasoconstriction syndrome 9.7
762 single ventricular heart 9.7
763 8p11 myeloproliferative syndrome 9.7
764 aneurysm 9.7
765 hypoxia 9.7
766 seizure disorder 9.7
767 posttransplant acute limbic encephalitis 9.7
768 familial long qt syndrome 9.7
769 inflammatory myopathy with abundant macrophages 9.7
770 bone sarcoma 9.7
771 virus-associated trichodysplasia spinulosa 9.7
772 rare surgical neurologic disease 9.7
773 dementia pugilistica 9.7
774 thyroid carcinoma 9.7
775 exudative vitreoretinopathy 1 9.7 TNF IL6 CXCL8
776 optic neuritis 9.7 TNF CXCR3 CXCL8
777 irritable bowel syndrome 9.7 TNF IL6 CXCL8
778 placenta disease 9.7 TNF IL6 CXCL8
779 abacavir allergy 9.7 GZMB CCL17
780 adult respiratory distress syndrome 9.7 TNF IL6 CXCL8
781 streptococcal toxic-shock syndrome 9.7 TNF IL6 IL2 CXCL8
782 opisthorchiasis 9.7 TNF IL4 CXCL8
783 nervous system disease 9.7 TNF IL6 IFNG CXCR3
784 plasmodium vivax malaria 9.7 TNF IL6 IL2 IFNG ICAM1
785 rheumatic fever 9.7 TNF IL6 IL2 IFNG ICAM1
786 trichomoniasis 9.6 TNF IL6 IL2 CXCL8
787 hair disease 9.6 TNF IL6 IL4 IL2 DSP
788 corneal disease 9.6 TNF IL6 CXCL8
789 bagassosis 9.6 TNF IL6 IL5 CXCL8
790 anus disease 9.6 TNF IL6 IL2 CXCL8
791 rectal disease 9.6 TNF IL6 IL2 CXCL8
792 complex regional pain syndrome 9.6 TNF IL6 IL2 CXCL8
793 obstructive jaundice 9.6 TNF IL6 IL2 CXCL8
794 sclerosing cholangitis 9.6 TNF IL6 IL2 CXCL8
795 cholangitis 9.6 TNF IL6 IL2 CXCL8
796 gingival overgrowth 9.6 TNF IL6 IL2 CXCL8
797 endometrial disease 9.6 TNF PTGS2 IL6 CXCL8
798 viral pneumonia 9.6 TNF IL6 CXCL8 CCL5
799 gastric ulcer 9.6 TNF PTGS2 IL6 CXCL8
800 chronic eosinophilic pneumonia 9.6 IL6 IL5 ICAM1 CXCR3 CCL5
801 leukocyte disease 9.6 TNF IL6 IL5 IL4 IL2
802 clonorchiasis 9.6 TNF IL2 IFNG CXCL8
803 vaginitis 9.6 TNF IL6 CXCL8 CCL5
804 atrophic gastritis 9.6 TNF PTGS2 IL6 CXCL8
805 pleural tuberculosis 9.6 TNF IL2 IFNG CXCL8
806 crohn's colitis 9.6 TNF IL2 IFNG CXCL8
807 macular retinal edema 9.6 TNF IL6 ICAM1 CXCL8
808 peanut allergy 9.6 IL5 IL4 IFNG CCL17
809 cardiac sarcoidosis 9.6 TNF IL5 IFNG CXCL8
810 cerebral palsy 9.6 TNF PTGS2 IL6 CXCL8
811 allergic bronchopulmonary aspergillosis 9.6 IL5 IL4 IFNG CCL17
812 eales disease 9.6 TNF IL6 IL4 IFNG
813 extrinsic cardiomyopathy 9.6 TNF IL6 IL4 IL2 ICAM1
814 retinal vascular disease 9.6 TNF IL6 ICAM1 CXCL8
815 alcoholic hepatitis 9.6 TNF IL6 ICAM1 CXCL8
816 varicose veins 9.6 TNF IL6 ICAM1 CXCL8
817 mycoplasma pneumoniae pneumonia 9.6 TNF IL6 IL4 IFNG
818 secondary progressive multiple sclerosis 9.6 IL4 IFNG CXCR3
819 sleep apnea 9.6 TNF IL6 ICAM1 CXCL8
820 echinococcosis 9.6 TNF IL6 IL5 IFNG CCL17
821 thyroiditis 9.6 TNF IL6 IL4 IL2 FASLG
822 avian influenza 9.5 TNF IL6 FASLG CXCL8
823 atherosclerosis susceptibility 9.5 TNF IL6 ICAM1 CXCL8
824 autoimmune uveitis 9.5 TNF IL4 IL2 IFNG ICAM1
825 central nervous system disease 9.5 TNF IL6 IFNG CXCR3
826 osteoarthritis 9.5 TNF PTGS2 IL6 CXCL8
827 coronary artery anomaly 9.5 TNF IL6 ICAM1 CXCL8
828 churg-strauss syndrome 9.5 TNF IL5 IL2 CXCL8 CCL17
829 cowpox 9.5 IL6 GZMB FAS CXCL8
830 burkitt lymphoma 9.5 TNF IL6 IL4 ICAM1 FAS
831 non-alcoholic fatty liver disease 9.5 TNF IL6 FAS CXCL8
832 filariasis 9.5 TNF IL6 IL5 IL2 IFNG CCL5
833 intermediate uveitis 9.5 TNF IL6 IL2 IFNG CXCR3
834 papillary conjunctivitis 9.5 IL6 IL4 CXCL8
835 giant papillary conjunctivitis 9.5 IL6 IL4 CXCL8
836 chronic granulomatous disease 9.5 TNF IFNG ICAM1 CXCL8
837 septic arthritis 9.5 IFNG CXCR3 CXCL8
838 colon adenocarcinoma 9.5 TNF PTGS2 FASLG FAS CXCL8
839 amebiasis 9.5 TNF IL4 ICAM1 CXCL8
840 keratopathy 9.5 TNF IL4 ICAM1 CXCL8
841 post-cardiac arrest syndrome 9.4 IL6 CXCL8
842 vaginal disease 9.4 TNF IL6 IL2 CXCL8 CCL5
843 tropical spastic paraparesis 9.4 IL6 IL2 IFNG CXCR3 CCL5
844 meconium aspiration syndrome 9.4 TNF IL6 IFNG CXCL8
845 sezary's disease 9.4 IL5 IL4 IL2 IFNG CCL17
846 primary systemic mycosis 9.4 TNF IL6 IL4 IL2 IFNG
847 microscopic colitis 9.4 TNF IL6 IL4 IL2 IFNG
848 gastritis 9.4 TNF PTGS2 IL6 CXCL8 CCL5
849 autoimmune gastritis 9.4 TNF IL6 IL4 IL2 IFNG
850 splenic disease 9.4 TNF IL6 IL4 IL2 IFNG
851 coccidiosis 9.4 TNF IL6 IL4 IL2 IFNG
852 viral encephalitis 9.4 TNF PTGS2 IL6 CXCL8 CCL5
853 subacute sclerosing panencephalitis 9.4 TNF IL6 IL4 IL2 IFNG
854 autoimmune disease of endocrine system 9.4 TNF IL6 IL4 IL2 IFNG
855 lymph node disease 9.4 TNF IL6 IL4 IL2 IFNG
856 autoimmune disease of gastrointestinal tract 9.4 TNF IL6 IL4 IL2 IFNG
857 pleural disease 9.4 TNF IL6 IFNG CXCL8
858 ascaris lumbricoides infection 9.4 IL6 IL5 IFNG CXCL8
859 testicular disease 9.4 TNF IL6 IL4 IL2 IFNG
860 spondyloarthropathy 9.4 TNF IL6 IL4 IL2 IFNG
861 lymphatic system disease 9.4 TNF IL6 IL4 IL2 IFNG
862 endocarditis 9.4 TNF IL6 IFNG CXCL8
863 hydronephrosis 9.4 IL6 ICAM1 CXCL8
864 pulmonary sarcoidosis 9.4 TNF IL2 IFNG ICAM1 CXCR3 CCL5
865 retinal detachment 9.4 TNF IL6 IFNG CXCL8
866 chronic mucocutaneous candidiasis 9.4 TNF IL6 IL5 IL4 IFNG
867 kidney cancer 9.4 TNF IL2 IFNG CXCL8
868 pleurisy 9.4 TNF IL2 IFNG ICAM1 CXCL8
869 q fever 9.4 TNF IL6 IL4 IFNG CCL5
870 radiculopathy 9.4 IL6 CXCR3 CXCL8 CCL5
871 schistosomiasis 9.4 TNF IL5 IL4 IL2 IFNG CCL5
872 extrinsic allergic alveolitis 9.4 IL6 CXCR3 CXCL8 CCL5
873 plasmodium falciparum malaria 9.4 TNF IL6 IL4 IFNG ICAM1
874 blepharitis 9.3 TNF IL6 IL4 CXCL8
875 streptococcus pneumonia 9.3 TNF IL6 IL4 CXCL8
876 proliferative glomerulonephritis 9.3 IL6 IL4 IFNG CXCR3
877 aggressive periodontitis 9.3 TNF IL6 IL4 CXCL8
878 bacterial vaginosis 9.3 TNF IL6 IL4 CXCL8
879 chorioamnionitis 9.3 TNF IL6 IL4 CXCL8
880 liver disease 9.3 TNF IL6 FASLG FAS CXCL8
881 lymphoma, non-hodgkin, familial 9.3 TNF IL6 IL4 IL2 GZMB FAS
882 fasciitis 9.3 TNF IL6 IL2 IFNG CXCL8
883 appendicitis 9.3 TNF IL6 IL2 IFNG CXCL8
884 juvenile rheumatoid arthritis 9.2 TNF IL6 IL2 IFNG CXCL8
885 silicosis 9.2 TNF IL4 FASLG FAS CXCL8
886 myositis 9.2 TNF IL6 IL2 IFNG CXCL8
887 posterior uveitis 9.2 TNF IL6 IL5 IL4 IL2 IFNG
888 parasitic helminthiasis infectious disease 9.2 TNF IL6 IL5 IL4 IL2 IFNG
889 monocytic leukemia 9.2 TNF IL6 IFNG FAS CXCL8
890 pyelonephritis 9.2 TNF IL6 IFNG CXCL8 CCL5
891 chronic conjunctivitis 9.2 TNF IL6 IL5 IL4 CXCL8
892 hypotrichosis 1 9.2 TNF IL6 IL4 IL2 CXCL8
893 prostatitis 9.2 TNF IL6 IL4 IL2 CXCL8
894 neuroblastoma 9.2 TNF PTGS2 IL6 IL2 IFNG FASLG
895 severe combined immunodeficiency 9.2 PTGS2 IL6 IL5 IL4 IL2 IFNG
896 eosinophilic pneumonia 9.2 IL5 IL4 CXCL8 CCL5 CCL17
897 pulmonary eosinophilia 9.2 IL5 IL4 CXCL8 CCL5 CCL17
898 lacrimal apparatus disease 9.1 TNF IL6 IL4 ICAM1 CXCL8
899 paranasal sinus disease 9.1 TNF IL5 IL4 IFNG CXCL8
900 food allergy 9.1 TNF IL5 IL4 IFNG CXCL8
901 muscular disease 9.1 TNF IL6 IL4 IL2 CXCL8
902 bone disease 9.1 TNF IL6 IL4 ICAM1 CXCL8
903 periapical granuloma 9.1 IL4 IL2 CXCR3 CXCL8 CCL5
904 pre-eclampsia 9.0 TNF IL6 IL4 ICAM1 CXCL8
905 mycobacterium tuberculosis 1 9.0 TNF IL4 IFNG GZMB GNLY CXCR3
906 viral meningitis 9.0 IL6 IFNG CXCR3 CXCL8 CCL5
907 pancreatic adenocarcinoma 9.0 TNF PTGS2 IL6 IL2 FASLG FAS
908 demyelinating disease 9.0 TNF IL6 IL4 IL2 IFNG ICAM1
909 esophageal cancer 8.9 TNF PTGS2 IL6 IL2 FASLG FAS
910 diabetes mellitus, insulin-dependent 8.9 TNF IL6 IL4 IL2 IFNG ICAM1
911 arteriosclerosis 8.9 IL6 IL4 IFNG ICAM1 CXCR3 CCL5
912 graves' disease 8.8 IL4 IFNG ICAM1 FASLG FAS CXCR3
913 commensal bacterial infectious disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
914 brucellosis 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
915 uveal disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
916 autoimmune disease of musculoskeletal system 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
917 peripheral nervous system disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
918 esophagitis 8.8 TNF PTGS2 IL6 IL5 IL4 CXCL8
919 connective tissue disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
920 bronchiolitis obliterans 8.8 TNF IL6 IFNG GZMB CXCR3 CXCL8
921 common variable immunodeficiency 8.8 TNF IL6 IL5 IL4 IL2 IFNG
922 gastric adenocarcinoma 8.8 TNF PTGS2 IL6 IFNG FASLG FAS
923 neuritis 8.8 TNF IL6 IL4 IFNG CXCL8 CCL5
924 visceral leishmaniasis 8.7 TNF IL4 IL2 IFNG CXCR3 CXCL8
925 allergic conjunctivitis 8.7 TNF IL5 IL4 IL2 IFNG ICAM1
926 pneumoconiosis 8.7 TNF PTGS2 IL6 IL4 FASLG FAS
927 leukemia, acute myeloid 8.7 TNF IL6 IL4 IL2 FASLG FAS
928 respiratory allergy 8.7 TNF IL6 IL5 IL4 CXCL8 CCL5
929 opportunistic mycosis 8.6 TNF IL6 IL5 IL4 IL2 IFNG
930 lichen disease 8.6 TNF IL6 IL4 IL2 IFNG ICAM1
931 cutaneous t cell lymphoma 8.6 IL5 IL4 IL2 IFNG GZMB FAS
932 castleman disease 8.6 IL6 IL5 IL4 IFNG ICAM1 DSP
933 allergic rhinitis 8.5 IL5 IL4 IFNG ICAM1 CXCL8 CCL5
934 periodontitis 8.5 TNF PTGS2 IL6 IL4 IFNG ICAM1
935 myelodysplastic syndrome 8.5 TNF IL6 IL2 IFNG GZMB FASLG
936 schizophrenia 8.4 TNF PTGS2 IL6 IL4 IL2 IFNG
937 human immunodeficiency virus infectious disease 8.4 TNF IL4 IL2 IFNG GZMB FASLG
938 primary bacterial infectious disease 8.4 TNF IL6 IL5 IL4 IL2 IFNG
939 parasitic protozoa infectious disease 8.4 TNF IL6 IL5 IL4 IL2 IFNG
940 behcet syndrome 8.4 TNF IL6 IL4 IL2 IFNG ICAM1
941 bone inflammation disease 8.4 TNF PTGS2 IL6 IL4 IL2 IFNG
942 cystitis 8.4 TNF PTGS2 IL6 IL4 IL2 ICAM1
943 hypersensitivity reaction type iv disease 8.3 TNF IL6 IL4 IL2 IFNG FASLG
944 cutaneous leishmaniasis 8.3 TNF IL6 IL5 IL4 IL2 IFNG
945 leishmaniasis 8.3 TNF IL6 IL5 IL4 IL2 IFNG
946 celiac disease 1 8.3 TNF IL6 IL5 IL4 IL2 IFNG
947 aspergillosis 8.3 TNF IL6 IL5 IL4 IFNG CXCL8
948 primary biliary cirrhosis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
949 dilated cardiomyopathy 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
950 immune system disease 8.2 TNF IL6 IL5 IL4 IL2 IFNG
951 uveitis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
952 relapsing-remitting multiple sclerosis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
953 hashimoto thyroiditis 8.2 TNF IL6 IL5 IL4 IL2 IFNG
954 hypertension, essential 8.1 TNF PTGS2 IL6 IL4 IL2 IFNG
955 autoimmune disease of central nervous system 8.0 TNF IL6 IL4 IL2 IFNG ICAM1
956 eye disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
957 nose disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
958 nasal cavity disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
959 bronchial disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
960 ovarian cancer 7.6 TNF PTGS2 IL6 IL4 IL2 IFNG
961 diabetes mellitus 7.6 TNF PTGS2 IL6 IL4 IL2 IFNG
962 multiple sclerosis 7.5 TNF IL6 IL5 IL4 IL2 IFNG
963 viral infectious disease 7.5 TNF IL6 IL4 IL2 IFNG ICAM1
964 rheumatoid arthritis 7.3 TNF PTGS2 IL6 IL4 IL2 IFNG

Comorbidity relations with Erythema Multiforme via Phenotypic Disease Network (PDN): (showing 3, show less)


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Erythema Multiforme:



Diseases related to Erythema Multiforme

Symptoms & Phenotypes for Erythema Multiforme

GenomeRNAi Phenotypes related to Erythema Multiforme according to GeneCards Suite gene sharing:

26 (showing 2, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CXCL8 FAS GZMB ICAM1 IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CXCL8 FAS FASLG GZMB ICAM1 IL2

MGI Mouse Phenotypes related to Erythema Multiforme:

45 (showing 13, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 CCL17 CXCR3 DSP FAS FASLG ICAM1
2 hematopoietic system MP:0005397 10.27 CCL17 CCL5 CXCR3 FAS FASLG ICAM1
3 immune system MP:0005387 10.25 CCL17 CCL5 CXCR3 FAS FASLG ICAM1
4 digestive/alimentary MP:0005381 10.24 DSP FAS FASLG ICAM1 IFNG IL2
5 cardiovascular system MP:0005385 10.22 CXCR3 DSP FAS FASLG ICAM1 IFNG
6 endocrine/exocrine gland MP:0005379 10.13 FAS FASLG ICAM1 IFNG IL2 IL4
7 integument MP:0010771 10.06 DSP FAS FASLG ICAM1 IFNG IL4
8 liver/biliary system MP:0005370 10.02 FAS FASLG IFNG IL2 IL4 IL5
9 neoplasm MP:0002006 10.02 CXCR3 FAS FASLG ICAM1 IFNG IL2
10 reproductive system MP:0005389 9.81 FAS FASLG IFNG IL2 IL4 IL5
11 renal/urinary system MP:0005367 9.8 CXCR3 FAS FASLG IFNG IL4 IL6
12 respiratory system MP:0005388 9.65 CXCR3 FAS FASLG IFNG IL2 IL4
13 vision/eye MP:0005391 9.28 FAS FASLG ICAM1 IFNG IL2 IL4

Drugs & Therapeutics for Erythema Multiforme

Drugs for Erythema Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 124, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
3
Azithromycin Approved Phase 4 83905-01-5 55185 447043
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Sargramostim Approved, Investigational Phase 4 123774-72-1, 83869-56-1
6
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8 Ophthalmic Solutions Phase 4
9 Antimetabolites Phase 4
10 Anti-Bacterial Agents Phase 4
11 Analgesics Phase 4
12 Central Nervous System Depressants Phase 4
13 Analgesics, Opioid Phase 4
14 Anti-Anxiety Agents Phase 4
15 Tranquilizing Agents Phase 4
16 Psychotropic Drugs Phase 4
17 Antimanic Agents Phase 4
18 Excitatory Amino Acid Antagonists Phase 4
19 Anticonvulsants Phase 4
20 Excitatory Amino Acids Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Hypolipidemic Agents Phase 4
23 Lipid Regulating Agents Phase 4
24 Neurotransmitter Agents Phase 4
25 Autonomic Agents Phase 4
26 Adrenergic Antagonists Phase 4
27 Adrenergic beta-Antagonists Phase 4
28 Sympatholytics Phase 4
29 Adrenergic Agents Phase 4
30 Sodium Channel Blockers Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Anti-Arrhythmia Agents Phase 4
33
Pioglitazone Approved, Investigational Phase 3 111025-46-8 4829
34
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
35
Lesinurad Approved, Investigational Phase 3 878672-00-5 53465279
36
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
37
Etravirine Approved Phase 3 269055-15-4 193962
38
tannic acid Approved Phase 2, Phase 3 1401-55-4
39
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
40
Maraviroc Approved, Investigational Phase 2, Phase 3 376348-65-1 3002977
41
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
42
Etanercept Approved, Investigational Phase 3 185243-69-0
43
Coal tar Approved Phase 3 8007-45-2
44
Lamotrigine Approved, Investigational Phase 2, Phase 3 84057-84-1 3878
45
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
46 Hypoglycemic Agents Phase 3
47 Antirheumatic Agents Phase 3
48 Renal Agents Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 3
50 Cytochrome P-450 CYP3A Inducers Phase 3
51 Reverse Transcriptase Inhibitors Phase 3
52 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
53 Anti-Infective Agents Phase 2, Phase 3
54 Anti-Retroviral Agents Phase 2, Phase 3
55 Antiviral Agents Phase 2, Phase 3
56 Anti-HIV Agents Phase 2, Phase 3
57 Immunologic Factors Phase 3
58 Cyclosporins Phase 3
59 Antifungal Agents Phase 3
60 Immunosuppressive Agents Phase 3
61 Calcineurin Inhibitors Phase 3
62 Anti-Inflammatory Agents, Non-Steroidal Phase 3
63 Emollients Phase 3
64 Antipsychotic Agents Phase 2, Phase 3
65 calcium channel blockers Phase 2, Phase 3
66 Calcium, Dietary Phase 2, Phase 3
67
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
68
Pembrolizumab Approved Phase 2 1374853-91-4
69
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
70
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
71 Antineoplastic Agents, Immunological Phase 2
72 Pharmaceutical Solutions Phase 2