EM
MCID: ERY003
MIFTS: 58

Erythema Multiforme (EM)

Categories: Immune diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Erythema Multiforme

MalaCards integrated aliases for Erythema Multiforme:

Name: Erythema Multiforme 12 74 52 36 54 43 15 17 71 32
Erythema Polymorphe, Erythema Multiforme Type 52
Dermatostomatitis, Erythema Multiforme Type 52
Herpes Iris, Erythema Multiforme Type 52
Febrile Mucocutaneous Syndrome 52
Erythema Multiforme Bullosum 52
Stevens-Johnson Syndrome 71
Em 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050185
KEGG 36 H01695
MeSH 43 D004892
ICD10 32 L51 L51.9
UMLS 71 C0014742 C0038325

Summaries for Erythema Multiforme

KEGG : 36 Erythema multiforme (EM) is an immune-mediated, mucocutaneous condition characterized by "target" lesions. Classically, EM has been separated into 2 subgroups, EM minor and EM major. In EM minor, lesions often present as papules, which might enlarge and eventually form the typical target lesion with erythema surrounding an area of central clearing. The rash in EM minor preferentially affects the limbs, specifically the extensor surfaces, however, it can also be seen throughout the body, excluding mucous membranes. EM major has mucous membrane involvement. The oral mucosa is most commonly affected, initially with edema that progresses to superficial erosions. Other surfaces that might be involved include the anogenital, ocular, and nasal mucosa. Although previously thought to be on a similar continuum of EM, and histologically appearing the same, Stevens-Johnson syndrome (SJS) is increasingly being considered a separate disease process. It is currently believed that EM is a result of an immune reaction to an inciting infectious or pharmacologic antigen. The most common infectious organisms in EM are herpes simplex virus types 1 and 2, as well as Mycoplasma pneumonia. The first line of treatment for EM is removal of the inciting factor when possible. Systemic steroids have been suggested as adjuvant therapy based on their immunosuppressant effects. To date, their use has been limited to EM major, as EM minor is self-limited.

MalaCards based summary : Erythema Multiforme, also known as erythema polymorphe, erythema multiforme type, is related to severe cutaneous adverse reaction and fixed drug eruption. An important gene associated with Erythema Multiforme is DSP (Desmoplakin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Gabapentin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A skin disease that is a type of allergic reaction located in skin, which occurs in response to medications, infections, or illness.

NIH Rare Diseases : 52 Erythema multiforme (EM) refers to a group of hypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus . In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics . In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).

Wikipedia : 74 Erythema multiforme (EM) is a skin condition of unknown cause; it is a type of erythema possibly... more...

Related Diseases for Erythema Multiforme

Diseases related to Erythema Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 959, show less)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 32.9 TNF GZMB GNLY FASLG FAS
2 fixed drug eruption 30.9 IL2 IFNG
3 pemphigus 30.7 TNF IL4 DSP
4 herpes zoster 30.6 TNF IL2 IFNG
5 exanthem 30.6 TNF IL6 IL2 CXCL8
6 chikungunya 30.3 TNF IL6 CCL5
7 urticaria 30.2 TNF PTGS2 IL6 IL5 IL4
8 dengue disease 30.1 TNF ICAM1 CCL5
9 angioedema 30.1 PTGS2 IL6 IL5
10 kawasaki disease 30.1 TNF IL6 IL4
11 purpura 30.1 TNF IL6 IL4
12 spondylitis 30.0 TNF IL6 IFNG
13 cellulitis 30.0 TNF IL6 IL5 DSP
14 dermatitis herpetiformis 29.9 TNF IL5 IL4 CXCL8
15 non-alcoholic steatohepatitis 29.9 TNF IL6
16 stevens-johnson syndrome/toxic epidermal necrolysis 29.9 IL5 IL2 IFNG FAS CXCR3 CCL5
17 orchitis 29.9 TNF IL6 IL2
18 chlamydia pneumonia 29.9 TNF IL6 CXCL8
19 acute generalized exanthematous pustulosis 29.9 PTGS2 CXCL8
20 haemophilus influenzae 29.8 TNF CXCL8
21 alopecia 29.8 TNF IL4 IL2 IFNG DSP
22 typhoid fever 29.8 TNF IL6 IFNG
23 chickenpox 29.8 TNF IL6 IL4 IL2 IFNG
24 soft tissue sarcoma 29.7 TNF IFNG
25 keratitis, hereditary 29.7 TNF IL6 CXCL8
26 tuberculoid leprosy 29.7 IL4 IL2 IFNG
27 measles 29.7 TNF IL6 IL2 IFNG CCL5
28 neurofibromatosis, type ii 29.6 TNF IL6 CXCL8
29 autoimmune hepatitis 29.6 TNF IL4 FAS
30 diphtheria 29.6 TNF IL5 IL4 IL2 IFNG
31 pharyngitis 29.6 TNF PTGS2 IL6 CXCL8
32 peptic ulcer disease 29.6 TNF PTGS2 CXCL8
33 poliomyelitis 29.6 TNF IL4 IFNG ICAM1
34 chorioretinitis 29.6 TNF IL6 IL2 IFNG
35 cytomegalovirus infection 29.6 TNF IL6 FAS CXCL8 CCL5
36 spinal cord injury 29.5 TNF IL6 CXCL8
37 pertussis 29.5 TNF IL6 CXCL8 CCL5
38 bacterial infectious disease 29.5 TNF IL6 IFNG CXCL8
39 herpangina 29.5 TNF IL6 IL4 IL2
40 cryoglobulinemia 29.5 TNF IL6 IFNG CXCR3
41 localized scleroderma 29.5 TNF IL6 IL4 IL2
42 thymoma 29.5 TNF IL6 IL4 IL2 DSP
43 pulpitis 29.5 TNF IL6 CXCL8
44 systemic scleroderma 29.5 TNF IL6 IL4 IFNG
45 dysentery 29.5 TNF IL6 CXCL8
46 hepatitis b 29.5 TNF IL6 IFNG CXCL8
47 pulmonary edema 29.5 TNF ICAM1 FASLG CXCL8
48 vaccinia 29.5 TNF IL6 IL2 ICAM1 GZMB
49 legionellosis 29.4 TNF IL6 CXCL8
50 bullous pemphigoid 29.4 IL5 IL4 DSP CXCL8 CCL5 CCL17
51 toxic oil syndrome 29.4 IL5 IL4 IFNG
52 acute graft versus host disease 29.3 TNF IL4 IL2 IFNG FASLG
53 human immunodeficiency virus type 1 29.3 TNF IL6 IL2 IFNG CCL5
54 acquired immunodeficiency syndrome 29.3 TNF IL6 IL2 IFNG ICAM1
55 graft-versus-host disease 29.2 TNF IL6 IL2 IFNG GZMB FASLG
56 endophthalmitis 29.2 TNF IL6 ICAM1 CXCL8
57 reactive arthritis 29.2 TNF IL6 IFNG CXCL8
58 sarcoidosis 1 29.1 TNF IL2 IFNG ICAM1 CXCR3 CCL5
59 latex allergy 29.1 TNF IL5 IL4 IFNG
60 bronchiectasis 29.1 TNF IL6 CXCL8
61 yellow fever 29.1 IL6 IL5 IL4 CCL5
62 irritant dermatitis 29.1 TNF IL6 IL4 CXCL8
63 folliculitis 29.0 IL5 IL4 IFNG GNLY CCL5
64 mycosis fungoides 29.0 IL5 IL2 IFNG GZMB CXCR3 CCL17
65 vascular disease 29.0 TNF PTGS2 IL6 IL2 IFNG ICAM1
66 fibromyalgia 29.0 TNF IL6 IL2 CXCL8
67 relapsing polychondritis 29.0 IL6 IL2 IFNG CXCL8
68 gout 29.0 TNF IL6 CXCL8
69 pericarditis 29.0 TNF IL6 IFNG CXCL8
70 bacterial meningitis 28.9 TNF IL6 IFNG CXCL8
71 pulmonary tuberculosis 28.9 TNF IL6 IL4 IL2 IFNG
72 psoriatic arthritis 28.9 TNF IL6 IL4 IL2 IFNG
73 rubella 28.9 TNF IL6 IL5 IL4 IL2 IFNG
74 lepromatous leprosy 28.9 TNF IL4 IL2 IFNG ICAM1 CCL17
75 fatty liver disease 28.9 TNF IL6 FAS CXCL8
76 synovitis 28.9 TNF IL6 ICAM1 CXCL8
77 drug-induced lupus erythematosus 28.9 TNF IL6 IL4 CXCL8
78 cholera 28.8 TNF IL6 IL4 CXCL8
79 orofacial granulomatosis 28.8 TNF IL4 IFNG CXCR3 CCL5
80 mastitis 28.8 IL6 ICAM1 CXCL8 CCL5
81 leukemia, chronic lymphocytic 28.8 TNF IL6 IL4 IL2 FAS CXCR3
82 coronary artery anomaly 28.8 TNF IL6 ICAM1 CXCL8
83 stomatitis 28.8 TNF IL6 IL4 IL2 IFNG CXCL8
84 influenza 28.8 TNF IL6 IFNG CXCL8 CCL5
85 acute promyelocytic leukemia 28.8 TNF IL6 ICAM1 FAS CXCL8
86 tetanus 28.7 TNF IL6 IL5 IL4 IL2 IFNG
87 cutaneous lupus erythematosus 28.7 TNF IL6 IFNG ICAM1 GZMB CXCR3
88 lymphopenia 28.7 IL6 IL4 IL2 IFNG FASLG FAS
89 endometriosis 28.7 PTGS2 IL6 CXCL8 CCL5
90 mumps 28.7 TNF IL6 IL2 IFNG CXCL8
91 hemophagocytic lymphohistiocytosis 28.7 TNF IFNG GZMB GNLY CXCL8
92 diarrhea 28.7 TNF IL6 IL5 IL2 IFNG CXCL8
93 chlamydia 28.6 TNF IL6 IL4 IFNG CXCL8
94 toxoplasmosis 28.6 TNF IL6 IL5 IL4 IFNG
95 paracoccidioidomycosis 28.6 TNF IL6 IL5 IL4 IL2 IFNG
96 renal cell carcinoma, nonpapillary 28.6 IL4 IL2 IFNG ICAM1 FASLG FAS
97 idiopathic interstitial pneumonia 28.6 IL4 IFNG ICAM1 CXCL8
98 cataract 28.5 TNF PTGS2 IL6 IL2 ICAM1 CXCL8
99 hypereosinophilic syndrome 28.5 IL5 IL4 IL2 IFNG CXCL8 CCL5
100 immune deficiency disease 28.5 TNF IL6 IL4 IL2 IFNG FASLG
101 severe acute respiratory syndrome 28.5 TNF IL6 IL2 IFNG CXCL8 CCL5
102 pulmonary fibrosis, idiopathic 28.4 TNF IL6 IL5 IL4 IFNG FASLG
103 myocarditis 28.4 TNF IL6 IL4 IL2 IFNG ICAM1
104 crohn's disease 28.4 TNF IL6 IL4 IL2 IFNG CXCL8
105 smallpox 28.3 TNF IL4 IL2 IFNG ICAM1 GZMB
106 colitis 28.3 TNF PTGS2 IL6 IL4 IL2 IFNG
107 basal cell carcinoma 28.3 TNF PTGS2 IL6 IL2 ICAM1 FASLG
108 ulcerative colitis 28.3 TNF IL6 IL4 IL2 IFNG ICAM1
109 tonsillitis 28.3 TNF IL6 IL4 IL2 IFNG CXCL8
110 candidiasis 28.2 TNF IL6 IL4 IL2 IFNG CXCL8
111 allergic hypersensitivity disease 28.2 TNF IL5 IL4 IL2 IFNG ICAM1
112 bronchitis 28.2 TNF IL6 IL5 IL4 CXCL8 CCL5
113 sarcoma 28.2 PTGS2 IL6 ICAM1 FAS CXCL8 CCL5
114 respiratory failure 28.2 TNF IL6 IL5 CXCL8 CCL5 CCL17
115 lymphadenitis 28.1 TNF IFNG ICAM1 FASLG FAS CXCR3
116 conjunctivitis 28.1 TNF IL6 IL5 IL4 IL2 IFNG
117 leptospirosis 28.1 TNF IL6 IL4 IL2 IFNG CXCL8
118 toxic shock syndrome 28.1 TNF IL6 IL4 IL2 IFNG CXCL8
119 conjunctival disease 28.0 TNF IL6 IL5 IL4 IL2 CXCL8
120 osteomyelitis 28.0 TNF IL6 IL4 IFNG CXCL8 CCL5
121 gastroenteritis 28.0 TNF IL6 IL5 IL4 IFNG CXCL8
122 gastroesophageal reflux 28.0 TNF PTGS2 IL6 IL5 IL4 CXCL8
123 viral hepatitis 28.0 TNF IL6 IL4 IL2 IFNG FASLG
124 leprosy 3 28.0 TNF IL6 IL5 IL4 IL2 IFNG
125 dengue hemorrhagic fever 28.0 TNF IL6 IL4 IFNG CXCL8
126 arthritis 27.9 TNF PTGS2 IL6 IL4 IFNG ICAM1
127 glioblastoma multiforme 27.8 TNF PTGS2 IL6 IL2 IFNG ICAM1
128 aphthous stomatitis 27.8 TNF IL6 IL5 IL4 IL2 IFNG
129 upper respiratory tract disease 27.7 TNF IL6 IL5 IL4 IL2 IFNG
130 body mass index quantitative trait locus 11 27.7 TNF PTGS2 IL6 IL4 ICAM1 CXCL8
131 chagas disease 27.7 TNF IL6 IL4 IL2 IFNG CXCL8
132 contact dermatitis 27.7 TNF IL6 IL5 IL4 IL2 IFNG
133 otitis media 27.7 TNF IL6 IL5 IL4 IFNG ICAM1
134 common cold 27.6 TNF IL6 IL5 IL4 ICAM1 CXCL8
135 allergic contact dermatitis 27.6 TNF IL6 IL5 IL4 IFNG ICAM1
136 cervical cancer 27.6 TNF PTGS2 IL6 IL2 IFNG FASLG
137 lichen planus 27.5 TNF IL6 IL4 IL2 IFNG ICAM1
138 alopecia areata 27.4 TNF IL6 IL4 IL2 IFNG ICAM1
139 chronic fatigue syndrome 27.4 TNF IL6 IL5 IL4 IL2 IFNG
140 bronchiolitis 27.4 TNF IL6 IL5 IL4 IFNG CXCL8
141 gingivitis 27.4 TNF IL6 IL4 IL2 IFNG ICAM1
142 dermatitis 27.4 TNF IL6 IL5 IL4 IL2 IFNG
143 allergic asthma 27.3 IL5 IL4 IFNG ICAM1 CXCL8 CCL5
144 aplastic anemia 27.3 TNF IL6 IL4 IL2 IFNG FASLG
145 keratoconjunctivitis 27.3 TNF IL6 IL5 IL4 IL2 IFNG
146 pneumonia 27.3 TNF IL6 IL5 IL4 IL2 IFNG
147 myocardial infarction 27.3 TNF PTGS2 IL6 IL4 IFNG ICAM1
148 hepatocellular carcinoma 27.3 TNF PTGS2 IL6 IL2 ICAM1 FASLG
149 thrombocytopenia 27.2 TNF IL6 IL4 IL2 IFNG ICAM1
150 pulmonary disease, chronic obstructive 27.2 TNF IL6 IL5 IL4 GZMB CXCR3
151 meningitis 27.1 TNF IL6 IL5 IL4 IL2 IFNG
152 skin disease 27.1 TNF IL6 IL5 IL4 IL2 IFNG
153 proteasome-associated autoinflammatory syndrome 1 27.1 TNF PTGS2 IL6 IL5 IL4 IFNG
154 rhinitis 27.0 TNF IL6 IL5 IL4 IFNG ICAM1
155 myeloma, multiple 27.0 TNF IL6 IL4 IL2 IFNG ICAM1
156 autoimmune disease 26.7 TNF IL6 IL5 IL4 IL2 IFNG
157 lung disease 26.7 TNF IL6 IL5 IL4 IFNG ICAM1
158 osteoporosis 26.7 TNF PTGS2 IL6 IL4 IL2 IFNG
159 psoriasis 26.7 TNF IL6 IL5 IL4 IL2 IFNG
160 interstitial lung disease 26.6 TNF IL6 IL5 IL4 IFNG ICAM1
161 systemic lupus erythematosus 26.5 TNF IL6 IL5 IL4 IL2 IFNG
162 dermatitis, atopic 26.0 TNF IL6 IL5 IL4 IL2 IFNG
163 trypanosomiasis 25.8 TNF IL6 IL4 IL2 IFNG ICAM1
164 inflammatory bowel disease 25.6 TNF PTGS2 IL6 IL5 IL4 IL2
165 malaria 25.2 TNF PTGS2 IL6 IL5 IL4 IL2
166 asthma 24.6 TNF IL6 IL5 IL4 IL2 IFNG
167 erythema multiforme major 12.7
168 eosinophilia-myalgia syndrome 12.2
169 early myoclonic encephalopathy 11.8
170 epileptic encephalopathy, early infantile, 3 11.5
171 erythromelalgia 11.4
172 pseudomembranous conjunctivitis 11.4
173 pulmonary embolism 11.3
174 encephalopathy, ethylmalonic 11.2
175 epileptic encephalopathy, early infantile, 4 11.2
176 alpha-1-antitrypsin deficiency 11.2
177 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 11.0
178 herpes simplex 11.0
179 cardiac arrest 10.6
180 lupus erythematosus 10.6
181 aztreonam allergy 10.5 IL5 IL2
182 kashin-beck disease 10.5 TNF FAS
183 dermatitis herpetiformis, familial 10.4
184 respiratory syncytial virus infectious disease 10.4 IL5 CCL5
185 cefuroxime allergy 10.4 PTGS2 IL5
186 type ii mixed cryoglobulinemia 10.4 FASLG FAS
187 external pathological resorption 10.4 TNF IL6
188 syphilis 10.4
189 palladium allergic contact dermatitis 10.4 TNF CCL17
190 ventricular fibrillation, paroxysmal familial, 1 10.3
191 bullous skin disease 10.3 IL5 DSP CCL5
192 mucositis 10.3
193 neutropenia 10.3
194 hepatitis 10.3
195 eosinophilic fasciitis 10.3 IL5 IFNG
196 hepatitis c virus 10.3
197 secondary syphilis 10.3
198 pustulosis of palm and sole 10.3
199 staphylococcal toxic shock syndrome 10.3 TNF IFNG
200 epstein-barr virus-associated gastric carcinoma 10.3 TNF FASLG FAS
201 autoimmune myocarditis 10.3 TNF IFNG
202 uremic pruritus 10.3 IL6 IL2
203 obesity-hypoventilation syndrome 10.3 IL6 CCL5
204 helix syndrome 10.3
205 drug allergy 10.3
206 histoplasmosis 10.3
207 dermatophytosis 10.3
208 hansen's disease 10.3
209 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.3 IL4 IL2
210 tropical endomyocardial fibrosis 10.3 TNF IL4
211 null-cell leukemia 10.3 TNF IL6
212 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6 IL5
213 actinic prurigo 10.2 TNF ICAM1
214 scleral disease 10.2 TNF IL6 IL2
215 autoimmune disease of cardiovascular system 10.2 TNF IL6 IL2
216 ocular motor apraxia 10.2
217 vasculitis 10.2
218 subacute cutaneous lupus erythematosus 10.2
219 chronic beryllium disease 10.2 TNF IFNG
220 scorpion envenomation 10.2 TNF IL6 CCL5
221 erysipelas 10.2 TNF IL6 IL2
222 burning mouth syndrome 10.2 TNF IL6 IL2
223 poems syndrome 10.2 TNF IL6 IL2
224 persistent polyclonal b-cell lymphocytosis 10.2 IL4 FAS
225 virus associated hemophagocytic syndrome 10.2 IL4 IL2
226 penile disease 10.2 TNF IL6 IL2
227 listeriosis 10.2 TNF IL6 IL2
228 stachybotrys chartarum 10.2 TNF IL6 CCL5
229 anaerobic pneumonia 10.2 IL6 CCL5
230 lymphocytic gastritis 10.2 GZMB FASLG FAS
231 lymphoid interstitial pneumonia 10.2 TNF IL6 IL2
232 spinal cord disease 10.2 TNF IL6 IL2
233 pfeiffer syndrome 10.2
234 pemphigus vulgaris, familial 10.2
235 hepatitis c 10.2
236 autoimmune progesterone dermatitis 10.2
237 adult t-cell leukemia 10.2 IL2 ICAM1 FAS
238 t-cell large granular lymphocyte leukemia 10.2 IL2 GZMB FASLG
239 pustulosis palmaris et plantaris 10.2 TNF IL5 CXCR3
240 rheumatoid vasculitis 10.2 TNF ICAM1
241 spotted fever 10.2 TNF IFNG CCL5
242 spotted fever rickettsiosis 10.2 TNF IFNG CCL5
243 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
244 meningoencephalitis 10.2 TNF IL6 CCL5
245 posterior urethral valves 10.2 TNF IL6
246 ileitis 10.2 TNF IL6 CCL5
247 jak3-deficient severe combined immunodeficiency 10.2 IL4 IL2
248 bipolar i disorder 10.1
249 blood coagulation disease 10.1 TNF IL6 IL2
250 vein disease 10.1 TNF IL6 ICAM1
251 hantavirus hemorrhagic fever with renal syndrome 10.1 TNF IL6 GZMB
252 dowling-degos disease 1 10.1
253 lung cancer 10.1
254 yemenite deaf-blind hypopigmentation syndrome 10.1
255 pemphigus gestationis 10.1
256 rabies 10.1
257 cicatricial pemphigoid 10.1
258 pemphigoid gestationis 10.1
259 granuloma annulare 10.1
260 mouth disease 10.1
261 genital herpes 10.1
262 pityriasis rosea 10.1
263 ritter's disease 10.1
264 48,xyyy 10.1
265 chronic graft versus host disease 10.1
266 drug reaction with eosinophilia and systemic symptoms 10.1
267 exfoliative dermatitis 10.1
268 linear iga disease 10.1
269 paraneoplastic pemphigus 10.1
270 nodular goiter 10.1 IL6 ICAM1 FAS
271 limb ischemia 10.1 TNF IL6 ICAM1
272 autoimmune vasculitis 10.1 TNF IL4 IL2
273 acute myocarditis 10.1 IL6 FASLG FAS
274 endomyocardial fibrosis 10.1 TNF IL5 IL4
275 peripheral artery disease 10.1 TNF IL6 ICAM1
276 substance abuse 10.1
277 kidney disease 10.1
278 syncope 10.1
279 rapidly involuting congenital hemangioma 10.1
280 toxic encephalopathy 10.1 TNF PTGS2 IL6
281 cow milk allergy 10.1 TNF IL5 IL4
282 milk allergy 10.1 TNF IL5 IL4
283 angiostrongyliasis 10.1 IL5 IL4 IL2
284 eosinophilic meningitis 10.1 IL5 IL4 IL2
285 fabry disease 10.1 TNF IL6 ICAM1
286 oral lichen planus 10.1 ICAM1 CXCR3 CCL5
287 acrocallosal syndrome 10.1
288 ischemia 10.1
289 vernal keratoconjunctivitis 10.1 IL5 IL4 CCL5
290 sickle cell anemia 10.1 TNF IL6 ICAM1
291 lymphomatoid papulosis 10.1 GZMB FAS
292 kimura disease 10.1 IL5 IL4 CCL5
293 colorectal adenoma 10.0 TNF PTGS2 IL6
294 paragonimiasis 10.0 IL5 CXCR3 CCL17
295 spondyloarthropathy 1 10.0
296 breast cancer 10.0
297 colorectal cancer 10.0
298 cryoglobulinemia, familial mixed 10.0
299 ocular cicatricial pemphigoid 10.0
300 porphyria cutanea tarda 10.0
301 small cell cancer of the lung 10.0
302 thymoma, familial 10.0
303 nail disorder, nonsyndromic congenital, 10 10.0
304 variola major 10.0
305 lymphoma 10.0
306 lymphocytic leukemia 10.0
307 ornithosis 10.0
308 lyme disease 10.0
309 nephrotic syndrome 10.0
310 ecthyma 10.0
311 inflammatory spondylopathy 10.0
312 entropion 10.0
313 porphyria 10.0
314 keratosis 10.0
315 melanoma 10.0
316 contagious pustular dermatitis 10.0
317 molluscum contagiosum 10.0
318 47,xyy 10.0
319 cutaneous larva migrans 10.0
320 kikuchi disease 10.0
321 perniosis 10.0
322 headache 10.0
323 stevens-johnson syndrome/toxic epidermal necrolysis overlap syndrome 10.0
324 encephalitis 10.0
325 traumatic brain injury 10.0
326 pik3ca-related overgrowth syndrome 10.0
327 intracranial berry aneurysm 10.0 TNF IL6 ICAM1
328 leukoregulin 10.0 PTGS2 CXCL8
329 lung abscess 10.0 TNF IL6 IFNG
330 esophagus melanoma 10.0 FAS CXCL8
331 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 GZMB FASLG CCL5
332 fungal meningitis 10.0 TNF IL6 IFNG
333 central nervous system vasculitis 10.0 TNF IL6 IFNG
334 childhood type dermatomyositis 10.0 TNF IL6 CXCR3
335 vascular dementia 10.0 TNF IL6 ICAM1
336 cardiac conduction defect 10.0
337 hair whorl 10.0
338 moyamoya disease 1 10.0
339 ataxia and polyneuropathy, adult-onset 10.0
340 dengue virus 10.0
341 cerebrovascular disease 10.0
342 chronic kidney disease 10.0
343 subacute delirium 10.0
344 amyloidosis 10.0
345 muscular dystrophy 10.0
346 brain injury 10.0
347 multicentric castleman disease 10.0 IL6 IL5 IFNG
348 oral tuberculosis 10.0 TNF IL2 IFNG GNLY
349 primary progressive multiple sclerosis 10.0 TNF IL4 ICAM1
350 mixed connective tissue disease 10.0 TNF IL6 IFNG
351 idiopathic neutropenia 10.0 TNF IL6 FASLG CCL5
352 melioidosis 10.0 TNF IL6 IFNG
353 wells syndrome 9.9 IL5 IL2 CXCL8
354 salmonellosis 9.9 TNF IL6 IFNG
355 inguinal hernia 9.9 PTGS2 IL6 ICAM1
356 gastrointestinal tuberculosis 9.9 TNF IFNG
357 ataxia-telangiectasia 9.9
358 helicobacter pylori infection 9.9
359 stroke, ischemic 9.9
360 body mass index quantitative trait locus 1 9.9
361 plague 9.9
362 acute myocardial infarction 9.9
363 hypoglycemia 9.9
364 hypertrophic cardiomyopathy 9.9
365 back pain 9.9
366 encephalopathy 9.9
367 head injury 9.9
368 trachoma 9.9 TNF IL6 IL4
369 onchocerciasis 9.9 IL5 IL4 IL2 CCL5
370 rheumatic heart disease 9.9 TNF IL6 IL4
371 annular erythema 9.9
372 major affective disorder 1 9.9
373 myoclonus and ataxia 9.9
374 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
375 meningioma, radiation-induced 9.9
376 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
377 meningioma, familial 9.9
378 major depressive disorder 9.9
379 legionnaire disease 9.9
380 major affective disorder 8 9.9
381 major affective disorder 9 9.9
382 psoriasis 14, pustular 9.9
383 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
384 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
385 cholangiocarcinoma 9.9
386 hydrops, lactic acidosis, and sideroblastic anemia 9.9
387 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
388 deficiency anemia 9.9
389 swine influenza 9.9
390 early congenital syphilis 9.9
391 peripheral t-cell lymphoma 9.9
392 glucocorticoid-induced osteoporosis 9.9
393 erythema elevatum diutinum 9.9
394 angioimmunoblastic t-cell lymphoma 9.9
395 dermatomyositis 9.9
396 parotitis 9.9
397 hand, foot and mouth disease 9.9
398 borderline personality disorder 9.9
399 anogenital venereal wart 9.9
400 t cell deficiency 9.9
401 disseminated intravascular coagulation 9.9
402 spinal meningioma 9.9
403 heart disease 9.9
404 myopia 9.9
405 tinea corporis 9.9
406 punctate epithelial keratoconjunctivitis 9.9
407 locked-in syndrome 9.9
408 telangiectasis 9.9
409 quadriplegia 9.9
410 keratoconjunctivitis sicca 9.9
411 balanitis 9.9
412 tinea unguium 9.9
413 myringitis bullosa hemorrhagica 9.9
414 facial paralysis 9.9
415 oral candidiasis 9.9
416 sporotrichosis 9.9
417 personality disorder 9.9
418 dermatomycosis 9.9
419 rheumatic disease 9.9
420 thrombocytopenia due to platelet alloimmunization 9.9
421 mental depression 9.9
422 ichthyosis 9.9
423 cholecystitis 9.9
424 rectum cancer 9.9
425 giant cell tumor 9.9
426 enthesopathy 9.9
427 tularemia 9.9
428 focal epilepsy 9.9
429 macrocytic anemia 9.9
430 acromegaly 9.9
431 agammaglobulinemia 9.9
432 epidermolysis bullosa 9.9
433 bilirubin metabolic disorder 9.9
434 newcastle disease 9.9
435 antiphospholipid syndrome 9.9
436 lipid metabolism disorder 9.9
437 neurodermatitis 9.9
438 bipolar disorder 9.9
439 mastocytosis 9.9
440 hypertrichosis 9.9
441 superficial basal cell carcinoma 9.9
442 spongiotic dermatitis 9.9
443 secretory meningioma 9.9
444 lymphoplasmacyte-rich meningioma 9.9
445 intrahepatic cholangiocarcinoma 9.9
446 pancreatitis 9.9
447 sleep disorder 9.9
448 hemolytic anemia 9.9
449 congestive heart failure 9.9
450 esophageal disease 9.9
451 anal canal squamous cell carcinoma 9.9
452 cutaneous anthrax 9.9
453 anthrax disease 9.9
454 epilepsy with generalized tonic-clonic seizures 9.9
455 hyperthyroidism 9.9
456 impetigo 9.9
457 herpetic whitlow 9.9
458 milker's nodule 9.9
459 seborrheic dermatitis 9.9
460 actinic keratosis 9.9
461 eczema herpeticum 9.9
462 hard palate cancer 9.9
463 lymphangitis 9.9
464 ulcerative stomatitis 9.9
465 hypersensitivity vasculitis 9.9
466 congenital syphilis 9.9
467 acute articular rheumatism 9.9
468 enteropathy-associated t-cell lymphoma 9.9
469 neisseria meningitidis infection 9.9
470 neonatal herpes 9.9
471 pemphigus foliaceus 9.9
472 pustular psoriasis 9.9
473 splenomegaly 9.9
474 depression 9.9
475 tremor 9.9
476 systemic autoimmune disease 9.9
477 glial tumor 9.9
478 bullous impetigo 9.9
479 acute liver failure 9.9
480 nickel allergic contact dermatitis 9.9 IL5 IL4 IFNG
481 combined t cell and b cell immunodeficiency 9.9 IL6 IL4 IL2
482 status asthmaticus 9.9 IL5 CXCL8 CCL5
483 acute transverse myelitis 9.9 IL6 CXCL8
484 herpes simplex virus keratitis 9.9 ICAM1 CXCL8
485 corticosteroid allergy 9.9 IL5 IL4 IFNG
486 neuromyelitis optica 9.9 IL6 IL5 IL4
487 cryptococcosis 9.9 TNF IL4 IFNG
488 mycobacterium abscessus 9.9 TNF CXCL8
489 brain edema 9.9 IL6 IL2 IFNG
490 autoimmune lymphoproliferative syndrome 9.9 TNF IL2 GZMB FASLG FAS
491 urinary schistosomiasis 9.9 IL5 IL4 IFNG
492 collagen disease 9.9 TNF IL6 IL4
493 vulvovaginal candidiasis 9.9 IL4 IL2 IFNG
494 carotid stenosis 9.9 TNF ICAM1 CXCL8
495 ige responsiveness, atopic 9.9 IL5 IL4 IFNG
496 angelucci's syndrome 9.9 IFNG CXCL8
497 arthropathy 9.8 TNF PTGS2 IL6 IFNG
498 end stage renal failure 9.8 TNF PTGS2 IL6 IL2 CCL5
499 alcohol dependence 9.8
500 alzheimer disease 9.8
501 cerebral amyloid angiopathy, cst3-related 9.8
502 papillomatosis, confluent and reticulated 9.8
503 polykaryocytosis inducer 9.8
504 triiodothyronine receptor auxiliary protein 9.8
505 chondrosarcoma 9.8
506 sudden infant death syndrome 9.8
507 tarp syndrome 9.8
508 body mass index quantitative trait locus 9 9.8
509 astigmatism 9.8
510 body mass index quantitative trait locus 8 9.8
511 panbronchiolitis, diffuse 9.8
512 gastrointestinal stromal tumor 9.8
513 body mass index quantitative trait locus 4 9.8
514 body mass index quantitative trait locus 10 9.8
515 endometrial cancer 9.8
516 body mass index quantitative trait locus 7 9.8
517 buruli ulcer 9.8
518 body mass index quantitative trait locus 12 9.8
519 body mass index quantitative trait locus 14 9.8
520 leptin deficiency or dysfunction 9.8
521 body mass index quantitative trait locus 18 9.8
522 body mass index quantitative trait locus 19 9.8
523 body mass index quantitative trait locus 20 9.8
524 early infantile epileptic encephalopathy 9.8
525 polycystic kidney disease 9.8
526 depersonalization disorder 9.8
527 disease of mental health 9.8
528 status epilepticus 9.8
529 hyperinsulinism 9.8
530 long qt syndrome 9.8
531 pulmonary fibrosis 9.8
532 erythrasma 9.8
533 ebola hemorrhagic fever 9.8
534 b-cell lymphoma 9.8
535 gas gangrene 9.8
536 venezuelan equine encephalitis 9.8
537 al amyloidosis 9.8
538 carcinoma showing thymus-like differentiation 9.8
539 cytokine deficiency 9.8
540 dwarfism 9.8
541 glioma 9.8
542 meningococcemia 9.8
543 chronic pain 9.8
544 fainting 9.8
545 myoclonus 9.8
546 ohtahara syndrome 9.8
547 african tick-bite fever 9.8 TNF IL6 IFNG CCL5
548 myelitis 9.8 TNF IL6 CXCL8
549 takayasu arteritis 9.8 TNF IL6 IL2 ICAM1 CCL5
550 fuchs' heterochromic uveitis 9.8 IL6 CXCL8
551 temporal arteritis 9.8 TNF IL6 IFNG CCL5
552 panniculitis 9.8 IFNG GZMB FASLG FAS
553 idiopathic anterior uveitis 9.8 TNF IL6 CXCL8
554 ileus 9.8 TNF IL6 IFNG ICAM1
555 transverse myelitis 9.8 TNF IL6 CXCL8
556 autoimmune disease of eyes, ear, nose and throat 9.8 TNF IL6 IL4 IL2
557 plasmacytoma 9.8 IL6 IL4 IL2
558 periapical periodontitis 9.8 TNF IL6 CXCL8
559 dental pulp disease 9.8 TNF IL6 CXCL8
560 urethritis 9.8 TNF IL6 CXCL8
561 blood group, globoside system 9.8 TNF IL6 CXCL8
562 vitreous disease 9.8 TNF IL6 CXCL8
563 cecal disease 9.8 TNF IL6 CXCL8
564 cervicitis 9.8 IL6 IL2 CXCL8
565 bronchopneumonia 9.8 TNF IL6 CXCL8
566 fallopian tube disease 9.8 TNF IL6 CXCL8
567 pyelitis 9.8 TNF IL6 CXCL8
568 toxicodendron dermatitis 9.8 TNF IL2 ICAM1 CXCL8
569 gingival disease 9.8 TNF IL6 CXCL8
570 capillary leak syndrome 9.8 IL6 IL2 CXCL8
571 necrotizing fasciitis 9.8 IL6 IL2 CXCL8
572 perinatal necrotizing enterocolitis 9.8 TNF IL6 CXCL8
573 adult-onset still's disease 9.8 TNF IL6 CXCL8
574 endometritis 9.8 TNF IL6 CXCL8
575 sebaceous gland disease 9.8 TNF IL6 CXCL8
576 rosacea 9.8 TNF IL6 CXCL8
577 endocardium disease 9.8 TNF IL6 CXCL8
578 middle ear disease 9.8 TNF IL6 CXCL8
579 apnea, obstructive sleep 9.8 TNF IL6 CXCL8
580 peptic esophagitis 9.8 PTGS2 IL6 CXCL8
581 bacterial sepsis 9.8 TNF IL6 CXCL8
582 mucocutaneous leishmaniasis 9.8 TNF IL4 IL2 IFNG
583 leukemia, acute monocytic 9.8 TNF IL6 CXCL8
584 preterm premature rupture of the membranes 9.8 TNF IL6 CXCL8
585 retinal vein occlusion 9.7 TNF IL6 CXCL8
586 acute cystitis 9.7 TNF IL6 CXCL8
587 interstitial cystitis 9.7 IL6 IL2 CXCL8
588 atopic keratoconjunctivitis 9.7 IL5 IL4 IL2 IFNG
589 pulmonary alveolar proteinosis 9.7 TNF IL6 CXCL8
590 scleritis 9.7 TNF IL5 IL4 IFNG
591 b-cell growth factor 9.7 IL6 IL4 IFNG
592 hepatitis a 9.7 TNF IL4 IL2 IFNG
593 cyclic neutropenia 9.7 TNF IFNG CXCL8
594 myasthenia gravis 9.7 TNF IL4 IL2 IFNG
595 duodenal ulcer 9.7 TNF IL6 CXCL8
596 aseptic meningitis 9.7 TNF IFNG CXCL8
597 omenn syndrome 9.7 TNF IL5 IL4 IFNG
598 cone-rod dystrophy 2 9.7 TNF IL6 IL2 FASLG FAS
599 alcoholic liver cirrhosis 9.7 TNF IL6 CXCL8
600 bacterial pneumonia 9.7 TNF IL6 CXCL8
601 aortic aneurysm, familial abdominal, 1 9.7
602 amyotrophic lateral sclerosis 1 9.7
603 atrial standstill 1 9.7
604 bladder cancer 9.7
605 carcinoid tumors, intestinal 9.7
606 cardiac arrhythmia 9.7
607 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.7
608 hand skill, relative 9.7
609 hypercholesterolemia, familial, 1 9.7
610 kaposi sarcoma 9.7
611 marfan syndrome 9.7
612 motion sickness 9.7
613 pick disease of brain 9.7
614 prostate cancer 9.7
615 thyroid cancer, nonmedullary, 1 9.7
616 cerebrotendinous xanthomatosis 9.7
617 chordoma 9.7
618 cystic fibrosis 9.7
619 epidermodysplasia verruciformis 1 9.7
620 hemochromatosis, type 1 9.7
621 mucolipidosis iv 9.7
622 ullrich congenital muscular dystrophy 1 9.7
623 osteogenic sarcoma 9.7
624 retinitis pigmentosa 9.7
625 peeling skin syndrome 1 9.7
626 oliver-mcfarlane syndrome 9.7
627 sarcoma, synovial 9.7
628 retinoschisis 1, x-linked, juvenile 9.7
629 xanthomatosis 9.7
630 branchiootic syndrome 1 9.7
631 macular degeneration, age-related, 1 9.7
632 light fixation seizure syndrome 9.7
633 diamond-blackfan anemia 2 9.7
634 nasopharyngeal carcinoma 9.7
635 coronary heart disease 1 9.7
636 anxiety 9.7
637 dermatofibrosarcoma protuberans 9.7
638 mitochondrial trifunctional protein deficiency 9.7
639 hyperinsulinemic hypoglycemia, familial, 5 9.7
640 hyperinsulinemic hypoglycemia, familial, 4 9.7
641 west nile virus 9.7
642 hamamy syndrome 9.7
643 bone mineral density quantitative trait locus 8 9.7
644 ewing sarcoma 9.7
645 diabetes mellitus, ketosis-prone 9.7
646 chondrosarcoma, extraskeletal myxoid 9.7
647 polycystic kidney disease 2 with or without polycystic liver disease 9.7
648 muscular dystrophy, congenital, lmna-related 9.7
649 bone mineral density quantitative trait locus 15 9.7
650 fanconi anemia, complementation group l 9.7
651 cortical malformations, occipital 9.7
652 membranous nephropathy 9.7
653 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.7
654 aortic valve disease 2 9.7
655 chorea, childhood-onset, with psychomotor retardation 9.7
656 hyperlipoproteinemia, type iii 9.7
657 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.7
658 west syndrome 9.7
659 angiosarcoma 9.7
660 acute diarrhea 9.7
661 aspiration pneumonia 9.7
662 diffuse large b-cell lymphoma 9.7
663 atrioventricular block 9.7
664 salivary gland carcinoma 9.7
665 mucosal melanoma 9.7
666 pain agnosia 9.7
667 ischemic colitis 9.7
668 atrial fibrillation 9.7
669 stuttering 9.7
670 oral hairy leukoplakia 9.7
671 ectopic pregnancy 9.7
672 physical disorder 9.7
673 meningococcal meningitis 9.7
674 mucolipidosis 9.7
675 thyroid gland anaplastic carcinoma 9.7
676 sensorineural hearing loss 9.7
677 neuroretinitis 9.7
678 ehrlichiosis 9.7
679 pneumonic plague 9.7
680 giardiasis 9.7
681 eastern equine encephalitis 9.7
682 japanese encephalitis 9.7
683 opioid abuse 9.7
684 horner's syndrome 9.7
685 dental pulp necrosis 9.7
686 visual epilepsy 9.7
687 goiter 9.7
688 leukemia 9.7
689 acute leukemia 9.7
690 choreatic disease 9.7
691 vertebrobasilar insufficiency 9.7
692 dementia 9.7
693 focal segmental glomerulosclerosis 9.7
694 rift valley fever 9.7
695 coccidioidomycosis 9.7
696 dental fluorosis 9.7
697 neuroleptic malignant syndrome 9.7
698 dumping syndrome 9.7
699 root resorption 9.7
700 benign familial neonatal epilepsy 9.7
701 endogenous depression 9.7
702 pneumothorax 9.7
703 neuroendocrine tumor 9.7
704 impotence 9.7
705 leiomyosarcoma 9.7
706 connective tissue cancer 9.7
707 post-traumatic stress disorder 9.7
708 dental caries 9.7
709 hemorrhagic disease 9.7
710 transient cerebral ischemia 9.7
711 lateral sclerosis 9.7
712 iron metabolism disease 9.7
713 glomerulonephritis 9.7
714 adenocarcinoma 9.7
715 nemaline myopathy 9.7
716 tracheal stenosis 9.7
717 rhabdomyosarcoma 9.7
718 fibrosarcoma 9.7
719 liposarcoma 9.7
720 retinitis 9.7
721 aortic aneurysm 9.7
722 lactic acidosis 9.7
723 thyroid gland papillary carcinoma 9.7
724 eosinophilic gastroenteritis 9.7
725 hyperglycemia 9.7
726 myopathy 9.7
727 spindle cell sarcoma 9.7
728 hepatitis e 9.7
729 clear cell renal cell carcinoma 9.7
730 sarcomatoid renal cell carcinoma 9.7
731 extraosseous chondrosarcoma 9.7
732 atrophic rhinitis 9.7
733 subependymal giant cell astrocytoma 9.7
734 liver cirrhosis 9.7
735 aortic disease 9.7
736 myxoid chondrosarcoma 9.7
737 acute stress disorder 9.7
738 mitochondrial metabolism disease 9.7
739 intestinal obstruction 9.7
740 oropharynx cancer 9.7
741 in situ carcinoma 9.7
742 learning disability 9.7
743 cervix uteri carcinoma in situ 9.7
744 ocular hypertension 9.7
745 epiglottitis 9.7
746 lipid storage disease 9.7
747 primary ciliary dyskinesia 9.7
748 hemophilia 9.7
749 collagen type vi-related disorders 9.7
750 hereditary transthyretin amyloidosis 9.7
751 mitochondrial disorders 9.7
752 amyloidosis aa 9.7
753 bronchopulmonary dysplasia 9.7
754 cervical intraepithelial neoplasia 9.7
755 gangliosidosis 9.7
756 leukoplakia 9.7
757 mycobacterium marinum 9.7
758 periodontal ehlers-danlos syndrome 9.7
759 reversible cerebral vasoconstriction syndrome 9.7
760 single ventricular heart 9.7
761 aneurysm 9.7
762 hypoxia 9.7
763 seizure disorder 9.7
764 posttransplant acute limbic encephalitis 9.7
765 familial long qt syndrome 9.7
766 inflammatory myopathy with abundant macrophages 9.7
767 bone sarcoma 9.7
768 virus-associated trichodysplasia spinulosa 9.7
769 rare surgical neurologic disease 9.7
770 dementia pugilistica 9.7
771 thyroid carcinoma 9.7
772 exudative vitreoretinopathy 1 9.7 TNF IL6 CXCL8
773 optic neuritis 9.7 TNF CXCR3 CXCL8
774 irritable bowel syndrome 9.7 TNF IL6 CXCL8
775 placenta disease 9.7 TNF IL6 CXCL8
776 abacavir allergy 9.7 GZMB CCL17
777 adult respiratory distress syndrome 9.7 TNF IL6 CXCL8
778 streptococcal toxic-shock syndrome 9.7 TNF IL6 IL2 CXCL8
779 opisthorchiasis 9.7 TNF IL4 CXCL8
780 nervous system disease 9.7 TNF IL6 IFNG CXCR3
781 plasmodium vivax malaria 9.7 TNF IL6 IL2 IFNG ICAM1
782 rheumatic fever 9.7 TNF IL6 IL2 IFNG ICAM1
783 trichomoniasis 9.6 TNF IL6 IL2 CXCL8
784 corneal disease 9.6 TNF IL6 CXCL8
785 hair disease 9.6 TNF IL6 IL4 IL2 DSP
786 bagassosis 9.6 TNF IL6 IL5 CXCL8
787 anus disease 9.6 TNF IL6 IL2 CXCL8
788 rectal disease 9.6 TNF IL6 IL2 CXCL8
789 complex regional pain syndrome 9.6 TNF IL6 IL2 CXCL8
790 obstructive jaundice 9.6 TNF IL6 IL2 CXCL8
791 sclerosing cholangitis 9.6 TNF IL6 IL2 CXCL8
792 cholangitis 9.6 TNF IL6 IL2 CXCL8
793 gingival overgrowth 9.6 TNF IL6 IL2 CXCL8
794 endometrial disease 9.6 TNF PTGS2 IL6 CXCL8
795 viral pneumonia 9.6 TNF IL6 CXCL8 CCL5
796 gastric ulcer 9.6 TNF PTGS2 IL6 CXCL8
797 chronic eosinophilic pneumonia 9.6 IL6 IL5 ICAM1 CXCR3 CCL5
798 leukocyte disease 9.6 TNF IL6 IL5 IL4 IL2
799 clonorchiasis 9.6 TNF IL2 IFNG CXCL8
800 vaginitis 9.6 TNF IL6 CXCL8 CCL5
801 atrophic gastritis 9.6 TNF PTGS2 IL6 CXCL8
802 pleural tuberculosis 9.6 TNF IL2 IFNG CXCL8
803 crohn's colitis 9.6 TNF IL2 IFNG CXCL8
804 macular retinal edema 9.6 TNF IL6 ICAM1 CXCL8
805 cardiac sarcoidosis 9.6 TNF IL5 IFNG CXCL8
806 peanut allergy 9.6 IL5 IL4 IFNG CCL17
807 cerebral palsy 9.6 TNF PTGS2 IL6 CXCL8
808 allergic bronchopulmonary aspergillosis 9.6 IL5 IL4 IFNG CCL17
809 eales disease 9.6 TNF IL6 IL4 IFNG
810 extrinsic cardiomyopathy 9.6 TNF IL6 IL4 IL2 ICAM1
811 retinal vascular disease 9.6 TNF IL6 ICAM1 CXCL8
812 alcoholic hepatitis 9.6 TNF IL6 ICAM1 CXCL8
813 varicose veins 9.6 TNF IL6 ICAM1 CXCL8
814 mycoplasma pneumoniae pneumonia 9.6 TNF IL6 IL4 IFNG
815 secondary progressive multiple sclerosis 9.6 IL4 IFNG CXCR3
816 sleep apnea 9.6 TNF IL6 ICAM1 CXCL8
817 echinococcosis 9.6 TNF IL6 IL5 IFNG CCL17
818 thyroiditis 9.6 TNF IL6 IL4 IL2 FASLG
819 hydronephrosis 9.6 IL6 ICAM1 CXCL8
820 avian influenza 9.5 TNF IL6 FASLG CXCL8
821 autoimmune uveitis 9.5 TNF IL4 IL2 IFNG ICAM1
822 atherosclerosis susceptibility 9.5 TNF IL6 ICAM1 CXCL8
823 osteoarthritis 9.5 TNF PTGS2 IL6 CXCL8
824 churg-strauss syndrome 9.5 TNF IL5 IL2 CXCL8 CCL17
825 cowpox 9.5 IL6 GZMB FAS CXCL8
826 burkitt lymphoma 9.5 TNF IL6 IL4 ICAM1 FAS
827 non-alcoholic fatty liver disease 9.5 TNF IL6 FAS CXCL8
828 filariasis 9.5 TNF IL6 IL5 IL2 IFNG CCL5
829 intermediate uveitis 9.5 TNF IL6 IL2 IFNG CXCR3
830 papillary conjunctivitis 9.5 IL6 IL4 CXCL8
831 giant papillary conjunctivitis 9.5 IL6 IL4 CXCL8
832 chronic granulomatous disease 9.5 TNF IFNG ICAM1 CXCL8
833 septic arthritis 9.5 IFNG CXCR3 CXCL8
834 colon adenocarcinoma 9.5 TNF PTGS2 FASLG FAS CXCL8
835 amebiasis 9.5 TNF IL4 ICAM1 CXCL8
836 keratopathy 9.5 TNF IL4 ICAM1 CXCL8
837 post-cardiac arrest syndrome 9.4 IL6 CXCL8
838 vaginal disease 9.4 TNF IL6 IL2 CXCL8 CCL5
839 tropical spastic paraparesis 9.4 IL6 IL2 IFNG CXCR3 CCL5
840 meconium aspiration syndrome 9.4 TNF IL6 IFNG CXCL8
841 sezary's disease 9.4 IL5 IL4 IL2 IFNG CCL17
842 primary systemic mycosis 9.4 TNF IL6 IL4 IL2 IFNG
843 microscopic colitis 9.4 TNF IL6 IL4 IL2 IFNG
844 gastritis 9.4 TNF PTGS2 IL6 CXCL8 CCL5
845 autoimmune gastritis 9.4 TNF IL6 IL4 IL2 IFNG
846 splenic disease 9.4 TNF IL6 IL4 IL2 IFNG
847 coccidiosis 9.4 TNF IL6 IL4 IL2 IFNG
848 viral encephalitis 9.4 TNF PTGS2 IL6 CXCL8 CCL5
849 subacute sclerosing panencephalitis 9.4 TNF IL6 IL4 IL2 IFNG
850 autoimmune disease of endocrine system 9.4 TNF IL6 IL4 IL2 IFNG
851 lymph node disease 9.4 TNF IL6 IL4 IL2 IFNG
852 autoimmune disease of gastrointestinal tract 9.4 TNF IL6 IL4 IL2 IFNG
853 pleural disease 9.4 TNF IL6 IFNG CXCL8
854 ascaris lumbricoides infection 9.4 IL6 IL5 IFNG CXCL8
855 testicular disease 9.4 TNF IL6 IL4 IL2 IFNG
856 spondyloarthropathy 9.4 TNF IL6 IL4 IL2 IFNG
857 lymphatic system disease 9.4 TNF IL6 IL4 IL2 IFNG
858 endocarditis 9.4 TNF IL6 IFNG CXCL8
859 pulmonary sarcoidosis 9.4 TNF IL2 IFNG ICAM1 CXCR3 CCL5
860 retinal detachment 9.4 TNF IL6 IFNG CXCL8
861 chronic mucocutaneous candidiasis 9.4 TNF IL6 IL5 IL4 IFNG
862 pleurisy 9.4 TNF IL2 IFNG ICAM1 CXCL8
863 kidney cancer 9.4 TNF IL2 IFNG CXCL8
864 q fever 9.4 TNF IL6 IL4 IFNG CCL5
865 radiculopathy 9.4 IL6 CXCR3 CXCL8 CCL5
866 schistosomiasis 9.4 TNF IL5 IL4 IL2 IFNG CCL5
867 extrinsic allergic alveolitis 9.4 IL6 CXCR3 CXCL8 CCL5
868 plasmodium falciparum malaria 9.3 TNF IL6 IL4 IFNG ICAM1
869 blepharitis 9.3 TNF IL6 IL4 CXCL8
870 streptococcus pneumonia 9.3 TNF IL6 IL4 CXCL8
871 proliferative glomerulonephritis 9.3 IL6 IL4 IFNG CXCR3
872 aggressive periodontitis 9.3 TNF IL6 IL4 CXCL8
873 bacterial vaginosis 9.3 TNF IL6 IL4 CXCL8
874 chorioamnionitis 9.3 TNF IL6 IL4 CXCL8
875 liver disease 9.3 TNF IL6 FASLG FAS CXCL8
876 fasciitis 9.3 TNF IL6 IL2 IFNG CXCL8
877 appendicitis 9.3 TNF IL6 IL2 IFNG CXCL8
878 juvenile rheumatoid arthritis 9.2 TNF IL6 IL2 IFNG CXCL8
879 silicosis 9.2 TNF IL4 FASLG FAS CXCL8
880 myositis 9.2 TNF IL6 IL2 IFNG CXCL8
881 posterior uveitis 9.2 TNF IL6 IL5 IL4 IL2 IFNG
882 parasitic helminthiasis infectious disease 9.2 TNF IL6 IL5 IL4 IL2 IFNG
883 monocytic leukemia 9.2 TNF IL6 IFNG FAS CXCL8
884 pyelonephritis 9.2 TNF IL6 IFNG CXCL8 CCL5
885 chronic conjunctivitis 9.2 TNF IL6 IL5 IL4 CXCL8
886 hypotrichosis 1 9.2 TNF IL6 IL4 IL2 CXCL8
887 prostatitis 9.2 TNF IL6 IL4 IL2 CXCL8
888 neuroblastoma 9.2 TNF PTGS2 IL6 IL2 IFNG FASLG
889 severe combined immunodeficiency 9.2 PTGS2 IL6 IL5 IL4 IL2 IFNG
890 eosinophilic pneumonia 9.2 IL5 IL4 CXCL8 CCL5 CCL17
891 pulmonary eosinophilia 9.2 IL5 IL4 CXCL8 CCL5 CCL17
892 lacrimal apparatus disease 9.1 TNF IL6 IL4 ICAM1 CXCL8
893 paranasal sinus disease 9.1 TNF IL5 IL4 IFNG CXCL8
894 food allergy 9.1 TNF IL5 IL4 IFNG CXCL8
895 muscular disease 9.1 TNF IL6 IL4 IL2 CXCL8
896 bone disease 9.1 TNF IL6 IL4 ICAM1 CXCL8
897 periapical granuloma 9.1 IL4 IL2 CXCR3 CXCL8 CCL5
898 pre-eclampsia 9.0 TNF IL6 IL4 ICAM1 CXCL8
899 mycobacterium tuberculosis 1 9.0 TNF IL4 IFNG GZMB GNLY CXCR3
900 viral meningitis 9.0 IL6 IFNG CXCR3 CXCL8 CCL5
901 pancreatic adenocarcinoma 9.0 TNF PTGS2 IL6 IL2 FASLG FAS
902 esophagitis 9.0 TNF PTGS2 IL6 IL5 IL4 CXCL8
903 demyelinating disease 9.0 TNF IL6 IL4 IL2 IFNG ICAM1
904 esophageal cancer 8.9 TNF PTGS2 IL6 IL2 FASLG FAS
905 diabetes mellitus, insulin-dependent 8.9 TNF IL6 IL4 IL2 IFNG ICAM1
906 arteriosclerosis 8.9 IL6 IL4 IFNG ICAM1 CXCR3 CCL5
907 graves' disease 8.8 IL4 IFNG ICAM1 FASLG FAS CXCR3
908 commensal bacterial infectious disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
909 brucellosis 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
910 uveal disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
911 autoimmune disease of musculoskeletal system 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
912 peripheral nervous system disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
913 connective tissue disease 8.8 TNF IL6 IL4 IL2 IFNG CXCL8
914 bronchiolitis obliterans 8.8 TNF IL6 IFNG GZMB CXCR3 CXCL8
915 common variable immunodeficiency 8.8 TNF IL6 IL5 IL4 IL2 IFNG
916 gastric adenocarcinoma 8.8 TNF PTGS2 IL6 IFNG FASLG FAS
917 neuritis 8.8 TNF IL6 IL4 IFNG CXCL8 CCL5
918 visceral leishmaniasis 8.7 TNF IL4 IL2 IFNG CXCR3 CXCL8
919 allergic conjunctivitis 8.7 TNF IL5 IL4 IL2 IFNG ICAM1
920 pneumoconiosis 8.7 TNF PTGS2 IL6 IL4 FASLG FAS
921 leukemia, acute myeloid 8.7 TNF IL6 IL4 IL2 FASLG FAS
922 respiratory allergy 8.7 TNF IL6 IL5 IL4 CXCL8 CCL5
923 opportunistic mycosis 8.6 TNF IL6 IL5 IL4 IL2 IFNG
924 lichen disease 8.6 TNF IL6 IL4 IL2 IFNG ICAM1
925 cutaneous t cell lymphoma 8.6 IL5 IL4 IL2 IFNG GZMB FAS
926 castleman disease 8.6 IL6 IL5 IL4 IFNG ICAM1 DSP
927 allergic rhinitis 8.5 IL5 IL4 IFNG ICAM1 CXCL8 CCL5
928 periodontitis 8.5 TNF PTGS2 IL6 IL4 IFNG ICAM1
929 peritonitis 8.5 TNF IL6 IL4 IFNG ICAM1 CXCL8
930 myelodysplastic syndrome 8.5 TNF IL6 IL2 IFNG GZMB FASLG
931 schizophrenia 8.4 TNF PTGS2 IL6 IL4 IL2 IFNG
932 human immunodeficiency virus infectious disease 8.4 TNF IL4 IL2 IFNG GZMB FASLG
933 primary bacterial infectious disease 8.4 TNF IL6 IL5 IL4 IL2 IFNG
934 parasitic protozoa infectious disease 8.4 TNF IL6 IL5 IL4 IL2 IFNG
935 behcet syndrome 8.4 TNF IL6 IL4 IL2 IFNG ICAM1
936 bone inflammation disease 8.4 TNF PTGS2 IL6 IL4 IL2 IFNG
937 cystitis 8.4 TNF PTGS2 IL6 IL4 IL2 ICAM1
938 hypersensitivity reaction type iv disease 8.3 TNF IL6 IL4 IL2 IFNG FASLG
939 cutaneous leishmaniasis 8.3 TNF IL6 IL5 IL4 IL2 IFNG
940 leishmaniasis 8.3 TNF IL6 IL5 IL4 IL2 IFNG
941 celiac disease 1 8.3 TNF IL6 IL5 IL4 IL2 IFNG
942 aspergillosis 8.3 TNF IL6 IL5 IL4 IFNG CXCL8
943 primary biliary cirrhosis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
944 dilated cardiomyopathy 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
945 immune system disease 8.2 TNF IL6 IL5 IL4 IL2 IFNG
946 uveitis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
947 relapsing-remitting multiple sclerosis 8.2 TNF IL6 IL4 IL2 IFNG ICAM1
948 hashimoto thyroiditis 8.2 TNF IL6 IL5 IL4 IL2 IFNG
949 hypertension, essential 8.1 TNF PTGS2 IL6 IL4 IL2 IFNG
950 autoimmune disease of central nervous system 8.0 TNF IL6 IL4 IL2 IFNG ICAM1
951 eye disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
952 nose disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
953 nasal cavity disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
954 bronchial disease 7.9 TNF IL6 IL5 IL4 IL2 IFNG
955 ovarian cancer 7.6 TNF PTGS2 IL6 IL4 IL2 IFNG
956 diabetes mellitus 7.6 TNF PTGS2 IL6 IL4 IL2 IFNG
957 multiple sclerosis 7.5 TNF IL6 IL5 IL4 IL2 IFNG
958 viral infectious disease 7.5 TNF IL6 IL4 IL2 IFNG ICAM1
959 rheumatoid arthritis 7.3 TNF PTGS2 IL6 IL4 IL2 IFNG

Comorbidity relations with Erythema Multiforme via Phenotypic Disease Network (PDN): (showing 3, show less)


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Erythema Multiforme:



Diseases related to Erythema Multiforme

Symptoms & Phenotypes for Erythema Multiforme

GenomeRNAi Phenotypes related to Erythema Multiforme according to GeneCards Suite gene sharing:

26 (showing 2, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CXCL8 FAS GZMB ICAM1 IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CXCL8 FAS FASLG GZMB ICAM1 IL2

MGI Mouse Phenotypes related to Erythema Multiforme:

45 (showing 13, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 CCL17 CXCR3 DSP FAS FASLG ICAM1
2 hematopoietic system MP:0005397 10.27 CCL17 CCL5 CXCR3 FAS FASLG ICAM1
3 immune system MP:0005387 10.25 CCL17 CCL5 CXCR3 FAS FASLG ICAM1
4 digestive/alimentary MP:0005381 10.24 DSP FAS FASLG ICAM1 IFNG IL2
5 cardiovascular system MP:0005385 10.22 CXCR3 DSP FAS FASLG ICAM1 IFNG
6 endocrine/exocrine gland MP:0005379 10.13 FAS FASLG ICAM1 IFNG IL2 IL4
7 integument MP:0010771 10.06 DSP FAS FASLG ICAM1 IFNG IL4
8 liver/biliary system MP:0005370 10.02 FAS FASLG IFNG IL2 IL4 IL5
9 neoplasm MP:0002006 10.02 CXCR3 FAS FASLG ICAM1 IFNG IL2
10 reproductive system MP:0005389 9.81 FAS FASLG IFNG IL2 IL4 IL5
11 renal/urinary system MP:0005367 9.8 CXCR3 FAS FASLG IFNG IL4 IL6
12 respiratory system MP:0005388 9.65 CXCR3 FAS FASLG IFNG IL2 IL4
13 vision/eye MP:0005391 9.28 FAS FASLG ICAM1 IFNG IL2 IL4

Drugs & Therapeutics for Erythema Multiforme

Drugs for Erythema Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 126, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
3
Azithromycin Approved Phase 4 83905-01-5 447043 55185
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
6
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8 Ophthalmic Solutions Phase 4
9 Antimetabolites Phase 4
10 Anti-Bacterial Agents Phase 4
11 Central Nervous System Depressants Phase 4
12 Analgesics Phase 4
13 Tranquilizing Agents Phase 4
14 Anti-Anxiety Agents Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Psychotropic Drugs Phase 4
17 Anticonvulsants Phase 4
18 Excitatory Amino Acids Phase 4
19 Antimanic Agents Phase 4
20 Analgesics, Opioid Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Hypolipidemic Agents Phase 4
23 Lipid Regulating Agents Phase 4
24 Neurotransmitter Agents Phase 4
25 Autonomic Agents Phase 4
26 Sympatholytics Phase 4
27 Adrenergic Antagonists Phase 4
28 Adrenergic beta-Antagonists Phase 4
29 Adrenergic Agents Phase 4
30 Sodium Channel Blockers Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Anti-Arrhythmia Agents Phase 4
33
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
34
Pioglitazone Approved, Investigational Phase 3 111025-46-8 4829
35
Lesinurad Approved, Investigational Phase 3 878672-00-5 53465279
36
Etravirine Approved Phase 3 269055-15-4 193962
37
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
38
tannic acid Approved Phase 2, Phase 3 1401-55-4
39
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
40
Maraviroc Approved, Investigational Phase 2, Phase 3 376348-65-1 3002977
41
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
42
Etanercept Approved, Investigational Phase 3 185243-69-0
43
Coal tar Approved Phase 3 8007-45-2
44
Lamotrigine Approved, Investigational Phase 2, Phase 3 84057-84-1 3878
45
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
46 Hypoglycemic Agents Phase 3
47 Renal Agents Phase 3
48 Reverse Transcriptase Inhibitors Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 3
50 Cytochrome P-450 CYP3A Inducers Phase 3
51 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
52 Anti-Infective Agents Phase 2, Phase 3
53 Anti-Retroviral Agents Phase 2, Phase 3
54 Antiviral Agents Phase 2, Phase 3
55 Anti-HIV Agents Phase 2, Phase 3
56 Immunologic Factors Phase 3
57 Antifungal Agents Phase 3
58 Dermatologic Agents Phase 3
59 Antirheumatic Agents Phase 3
60 Immunosuppressive Agents Phase 3
61 Calcineurin Inhibitors Phase 3
62 Cyclosporins Phase 3
63 Gastrointestinal Agents Phase 3
64 Anti-Inflammatory Agents, Non-Steroidal Phase 3
65 Emollients Phase 3
66 Antipsychotic Agents Phase 2, Phase 3
67 Calcium, Dietary Phase 2, Phase 3
68 calcium channel blockers Phase 2, Phase 3
69
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
70
Pembrolizumab Approved Phase 2 1374853-91-4
71
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
72
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
73 Antineoplastic Agents, Immunological Phase 2
74 Pharmaceutical Solutions Phase 2
75 Chelating Agents Phase 2
76 Iron Chelating Agents Phase 2
77 Fibrin Tissue Adhesive Phase 1
78 Coagulants Phase 1