Aliases & Classifications for Erythroplakia

MalaCards integrated aliases for Erythroplakia:

Name: Erythroplakia 53
Erythroplasia 73

Classifications:



External Ids:

UMLS 73 C0014818

Summaries for Erythroplakia

MalaCards based summary : Erythroplakia, also known as erythroplasia, is related to leukoplakia and oral cancer. An important gene associated with Erythroplakia is ABCG2 (ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Aminolevulinic acid and Metformin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland.

Wikipedia : 76 Erythroplakia (or erythroplasia) is a clinical term to describe any erythematous (red) area on a mucous... more...

Related Diseases for Erythroplakia

Diseases related to Erythroplakia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukoplakia 10.4
2 oral cancer 10.1
3 lichen planus 10.0
4 oral leukoplakia 10.0
5 oral lichen planus 10.0
6 fanconi anemia, complementation group a 9.8
7 graft-versus-host disease 9.8
8 chronic graft versus host disease 9.8
9 brain cancer 9.5 ABCG2 BMI1
10 hematologic cancer 9.2 ABCG2 BMI1

Graphical network of the top 20 diseases related to Erythroplakia:



Diseases related to Erythroplakia

Symptoms & Phenotypes for Erythroplakia

Drugs & Therapeutics for Erythroplakia

Drugs for Erythroplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 1, Phase 2 106-60-5 137
2
Metformin Approved Phase 2 657-24-9 14219 4091
3
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
4 Dermatologic Agents Phase 1, Phase 2,Not Applicable
5 Pharmaceutical Solutions Phase 1, Phase 2
6 Photosensitizing Agents Phase 1, Phase 2,Not Applicable
7 Hypoglycemic Agents Phase 2
8
Trioxsalen Approved Not Applicable 3902-71-4 5585
9 Ether Not Applicable
10 Hematoporphyrin Derivative Not Applicable
11 Dihematoporphyrin Ether Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Oral Premalignant Lesions With 5-ALA PDT Completed NCT00571974 Phase 1, Phase 2 5-Aminolevulinic Acid (Levulan KerastickTM)
2 Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion Active, not recruiting NCT02581137 Phase 2 Metformin Hydrochloride
3 Pioglitazone for Oral Premalignant Lesions Terminated NCT00951379 Phase 2 Pioglitazone hydrochloride
4 Natural History of Oro-pharyngeal Cancer Precursors Completed NCT00179361
5 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
6 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Recruiting NCT03418454
7 Fluorescence & Reflectance Imaging to Detect Oral Neoplasia Recruiting NCT00542373 Not Applicable
8 Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Recurrent Mouth or Throat Dysplasia or Recurrent In Situ Cancer or Stage I Cancer of the Mouth or Throat Terminated NCT00530088 Not Applicable porfimer sodium;Photdynamic Therapy (PDT)

Search NIH Clinical Center for Erythroplakia

Genetic Tests for Erythroplakia

Anatomical Context for Erythroplakia

MalaCards organs/tissues related to Erythroplakia:

41
Salivary Gland

Publications for Erythroplakia

Articles related to Erythroplakia:

(show all 30)
# Title Authors Year
1
Oral erythroplakia-What is it? ( 29480616 )
2018
2
Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia. ( 29344996 )
2018
3
A plea to provide best evidence in trials under sample-size restrictions: the example of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients. ( 28545482 )
2017
4
Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature. ( 29183344 )
2017
5
Outcome of excision of oral erythroplakia. ( 25467247 )
2015
6
Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology. ( 25975717 )
2015
7
Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer. ( 22725270 )
2013
8
Leukoplakia and erythroplakia of the oral mucosa--a brief overview. ( 23957095 )
2012
9
Expression of podoplanin and ABCG2 in oral erythroplakia correlate with oral cancer development. ( 22525603 )
2012
10
Oral cancer and oral erythroplakia: an update and implication for clinicians. ( 21884139 )
2011
11
Use of narrow band imaging guidance in the management of oral erythroplakia. ( 21036438 )
2011
12
Oral erythroplakia and speckled leukoplakia: retrospective analysis of 13 cases. ( 19575119 )
2009
13
Oral pathology: erythroplakia. ( 19326610 )
2008
14
A clinicopathologic study of oral leukoplakia and erythroplakia in a Thai population. ( 17823667 )
2007
15
Oral erythroplakia--a review. ( 15975518 )
2005
16
Chewing tobacco, alcohol, and the risk of erythroplakia. ( 10919731 )
2000
17
Experimental intervention study about recognition of erythroplakia by undergraduate dental students. ( 10858764 )
1999
18
A high prevalence of p53 mutations in pre-malignant oral erythroplakia. ( 9935172 )
1999
19
Erythroplakia: the dangerous red mucosa. ( 9002888 )
1995
20
Oral leukoplakia and erythroplakia: a review and update. ( 7833463 )
1994
21
Dysplasia in salivary gland ducts in sublingual leukoplakia and erythroplakia. ( 3460008 )
1986
22
Leukoplakia and erythroplakia of the mouth. ( 6964200 )
1982
23
Erythroplakia and the detection of oral malignancy. ( 6951213 )
1981
24
Erythroplakia of Queyrat of the oral mucosa. A report of 2 cases. ( 7250473 )
1981
25
Oral lichen planus, leukoplakia and erythroplakia: some observations on diagnosis and clinical management. ( 6934472 )
1980
26
Leukoplakia and erythroplakia in early oral cancer...an update. ( 290694 )
1978
27
Oral lichen planus, leukoplakia and erythroplakia: some observations on diagnosis and clinical management. ( 289871 )
1978
28
Erythroplakia of the oral cavity. ( 1182656 )
1975
29
Erythroplakia of the mouth and carcinoma-in-situ of the oral mucosa. ( 4516324 )
1973
30
Erythroplakia of the mouth. ( 4509562 )
1972

Variations for Erythroplakia

Expression for Erythroplakia

Search GEO for disease gene expression data for Erythroplakia.

Pathways for Erythroplakia

Pathways related to Erythroplakia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 ABCG2 ALDH1A1
2 10.52 ABCG2 BMI1

GO Terms for Erythroplakia

Sources for Erythroplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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