Esophageal Adenoid Cystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Esophageal Adenoid Cystic Carcinoma

MalaCards integrated aliases for Esophageal Adenoid Cystic Carcinoma:

Name: Esophageal Adenoid Cystic Carcinoma ¹¹ ¹⁴ ⁷¹

Adenoid Cystic Carcinoma, Esophagus ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4878

NCIt ⁴⁹ C5342

UMLS ⁷¹ C1333441

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Summaries for Esophageal Adenoid Cystic Carcinoma

Disease Ontology: ¹¹ An esophageal carcinoma that derives from epithelial cells of the salivary gland.

MalaCards based summary: Esophageal Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma, esophagus, is related to adenoid cystic carcinoma and lacrimal gland mucoepidermoid carcinoma, and has symptoms including pain An important gene associated with Esophageal Adenoid Cystic Carcinoma is CRTC3 (CREB Regulated Transcription Coactivator 3), and among its related pathways/superpathways are Transcriptional activation of mitochondrial biogenesis and Circadian Clock. Affiliated tissues include salivary gland.

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Related Diseases for Esophageal Adenoid Cystic Carcinoma

Diseases related to Esophageal Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid cystic carcinoma	10.3
2	lacrimal gland mucoepidermoid carcinoma	9.9	CRTC3 CRTC1
3	human t-cell leukemia virus type 1	9.9	CRTC3 CRTC1
4	clear cell hidradenoma	9.9	CRTC3 CRTC1
5	hidradenoma	9.9	CRTC3 CRTC1
6	pleomorphic adenoma carcinoma	9.9	CRTC3 CRTC1
7	myoepithelial carcinoma	9.8	CRTC1 ANO1
8	tonsil cancer	9.7	CRTC3 CRTC1
9	mammary analogue secretory carcinoma	9.6	CRTC1 ANO1
10	acinar cell carcinoma	9.6	CRTC1 ANO1
11	epithelial-myoepithelial carcinoma	9.5	CRTC3 CRTC1 ANO1
12	salivary gland disease	9.5	CRTC3 CRTC1 ANO1
13	salivary gland carcinoma	9.5	CRTC3 CRTC1 ANO1

Graphical network of the top 20 diseases related to Esophageal Adenoid Cystic Carcinoma:

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Symptoms & Phenotypes for Esophageal Adenoid Cystic Carcinoma

UMLS symptoms related to Esophageal Adenoid Cystic Carcinoma:

pain

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Drugs & Therapeutics for Esophageal Adenoid Cystic Carcinoma

Search Clinical Trials, NIH Clinical Center for Esophageal Adenoid Cystic Carcinoma

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Genetic Tests for Esophageal Adenoid Cystic Carcinoma

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Anatomical Context for Esophageal Adenoid Cystic Carcinoma

Organs/tissues related to Esophageal Adenoid Cystic Carcinoma:

MalaCards : Salivary Gland

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Publications for Esophageal Adenoid Cystic Carcinoma

Articles related to Esophageal Adenoid Cystic Carcinoma:

#	Title	Authors	PMID	Year
1	Laparoscopic Transhiatal Esophagectomy With En Bloc Posterior Tracheal Wall Resection. ⁶²	Pendleton AC...Seder CW	35218704	2022
2	A Small Esophageal Adenoid Cystic Carcinoma Treated by Endoscopic Submucosal Dissection. ⁶²	Ding X...Shen S	35718338	2022
3	Underwater endoscopic mucosal resection of upper gastrointestinal subepithelial tumors: A case series pilot study (with video). ⁶²	Kim SJ...Ryu DG	36254017	2022
4	Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma. ⁶²	Yoshikawa K...Saruta M	29259386	2017
5	A case of adenoid cystic carcinoma of the esophagus. ⁶²	Sawada G...Hatanaka N	26943443	2015
6	Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. ⁶²	De Dosso S...Saletti P	19688981	2009
7	Primary esophageal adenoid cystic carcinoma. ⁶²	Na YJ...Cho MS	20485637	2007
8	Primary adenoid cystic carcinoma of the esophagus. Report of a case and its histochemical characterization. ⁶²	Akamatsu T...Katsuyama T	3028038	1986
9	Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy. ⁶²	Petursson SR	3004692	1986

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Genes for Esophageal Adenoid Cystic Carcinoma

Genes related to Esophageal Adenoid Cystic Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRTC3	CREB Regulated Transcription Coactivator 3	Protein Coding	4.91	DISEASES inferred ¹⁴
2	PHLDA2	Pleckstrin Homology Like Domain Family A Member 2	Protein Coding	4.88	DISEASES inferred ¹⁴
3	KCNIP4	Potassium Voltage-Gated Channel Interacting Protein 4	Protein Coding	4.84	DISEASES inferred ¹⁴
4	ANO1	Anoctamin 1	Protein Coding	4.54	DISEASES inferred ¹⁴
5	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	4.36	DISEASES inferred ¹⁴

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Variations for Esophageal Adenoid Cystic Carcinoma

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Expression for Esophageal Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Esophageal Adenoid Cystic Carcinoma.

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Pathways for Esophageal Adenoid Cystic Carcinoma

Pathways related to Esophageal Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional activation of mitochondrial biogenesis ⁶⁶ Show member pathways Activation of PPARGC1A (PGC-1alpha) by phosphorylation ⁶⁶ Cristae formation ⁶⁶ Formation of ATP by chemiosmotic coupling ⁶⁶ Mitochondrial biogenesis ⁶⁶ Mitochondrial transcription initiation ⁶⁶ Mitochondrial transcription termination ⁶⁶ Transcription from mitochondrial promoters ⁶⁶	11.29	CRTC3 CRTC1
2	Circadian Clock ⁶⁶ Show member pathways BMAL1:CLOCK,NPAS2 activates circadian gene expression ⁶⁶ Circadian Clock in Mammals ⁶⁴ Heme signaling ⁶⁶ NR1D1 (REV-ERBA) represses gene expression ⁶⁶ RORA activates gene expression ⁶⁶	10.87	CRTC3 CRTC1

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GO Terms for Esophageal Adenoid Cystic Carcinoma

Biological processes related to Esophageal Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homotetramerization	GO:0051289	9.46	CRTC3 CRTC1
2	energy homeostasis	GO:0097009	9.26	CRTC3 CRTC1
3	positive regulation of CREB transcription factor activity	GO:0032793	8.92	CRTC3 CRTC1

Molecular functions related to Esophageal Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cAMP response element binding protein binding	GO:0008140	8.92	CRTC3 CRTC1

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Sources for Esophageal Adenoid Cystic Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ESP012 MIFTS: 20	Esophageal Adenoid Cystic Carcinoma Categories: Cancer diseases, Gastrointestinal diseases	Data Licensing For inquiries, contact: [email protected]
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