MCID: ESP006
MIFTS: 32

Esophageal Adenosquamous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Adenosquamous Carcinoma

MalaCards integrated aliases for Esophageal Adenosquamous Carcinoma:

Name: Esophageal Adenosquamous Carcinoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5625
NCIt 50 C27421
UMLS 70 C2063886

Summaries for Esophageal Adenosquamous Carcinoma

Disease Ontology : 12 An esophageal carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Esophageal Adenosquamous Carcinoma is related to adenosquamous carcinoma and esophageal disease. An important gene associated with Esophageal Adenosquamous Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Developmental Biology and ErbB4 Pathway. Affiliated tissues include breast, colon and lung, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Esophageal Adenosquamous Carcinoma

Diseases related to Esophageal Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 29.8 TP53 KRT7 KRT5 KRT18 CEACAM5
2 esophageal disease 29.5 TP53 ERBB2 CEACAM5 CDH1
3 squamous cell carcinoma 29.3 TP53 KRT7 ERBB2 CEACAM5 CDH1
4 esophageal cancer 29.1 TP53 JUN IGFBP3 ERBB2 CEACAM5 CDX2
5 ureter squamous cell carcinoma 10.4 KRT7 KRT5
6 inverted transitional papilloma 10.4 KRT7 KRT5
7 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
8 ceruminoma 10.4 KRT7 KRT5
9 subareolar duct papillomatosis 10.4 KRT7 KRT5
10 nipple benign neoplasm 10.4 KRT7 KRT5
11 anal canal paget's disease 10.4 KRT7 CDX2
12 auditory system benign neoplasm 10.4 KRT7 KRT5
13 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
14 anal gland adenocarcinoma 10.4 KRT7 CDX2
15 anus adenocarcinoma 10.4 KRT7 CDX2
16 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
17 adenosquamous colon carcinoma 10.4 KRT7 CDX2
18 bartholin's gland disease 10.4 KRT7 CDX2
19 bartholin's gland carcinoma 10.4 KRT7 CDX2
20 cystitis cystica 10.4 KRT7 CDX2
21 mucinous intrahepatic cholangiocarcinoma 10.4 KRT7 CDX2
22 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
23 sensory organ benign neoplasm 10.3 KRT7 KRT5
24 gallbladder squamous cell carcinoma 10.3 KRT5 CEACAM5
25 gastric squamous cell carcinoma 10.3 KRT7 KRT5
26 jejunal cancer 10.3 KRT7 CDX2
27 leukoplakia of penis 10.3 KRT7 CEACAM5
28 middle ear adenocarcinoma 10.3 KRT7 KRT5
29 urethral villous adenoma 10.3 KRT7 CEACAM5
30 balloon cell malignant melanoma 10.3 KRT7 KRT5
31 descending colon cancer 10.3 CEACAM5 CDX2
32 appendix adenocarcinoma 10.3 KRT7 CDX2
33 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 CDX2
34 jejunal adenocarcinoma 10.3 KRT7 CDX2
35 colon leiomyosarcoma 10.3 KRT5 CEACAM5
36 nephrogenic adenoma of the urethra 10.3 KRT7 KRT5
37 trachea carcinoma 10.3 KRT7 KRT5
38 pancreatic serous cystadenocarcinoma 10.3 KRT7 CEACAM5
39 lipid-rich breast carcinoma 10.3 KRT5 ERBB2
40 bile duct cystadenocarcinoma 10.3 KRT7 CEACAM5
41 rectosigmoid junction neoplasm 10.3 KRT7 CEACAM5
42 transverse colon cancer 10.3 KRT7 CEACAM5
43 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
44 endobronchial lipoma 10.3 KRT7 KRT5
45 vaginal adenoma 10.3 KRT7 CDX2
46 colonic lymphangioma 10.3 KRT7 CEACAM5
47 solid adenocarcinoma with mucin production 10.3 KRT7 KRT5
48 breast papillary carcinoma 10.3 KRT5 ERBB2
49 biliary papillomatosis 10.3 KRT7 CEACAM5
50 vaginal benign neoplasm 10.3 KRT7 CDX2

Graphical network of the top 20 diseases related to Esophageal Adenosquamous Carcinoma:



Diseases related to Esophageal Adenosquamous Carcinoma

Symptoms & Phenotypes for Esophageal Adenosquamous Carcinoma

GenomeRNAi Phenotypes related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CDH1 IGFBP3 JUN KRT18 KRT7 PDPK1

MGI Mouse Phenotypes related to Esophageal Adenosquamous Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 CDH1 CDX2 ERBB2 IGFBP3 JUN KRT14
2 growth/size/body region MP:0005378 10.1 CDH1 CDX2 ERBB2 IGFBP3 JUN KRT14
3 endocrine/exocrine gland MP:0005379 10.02 CDH1 CDX2 ERBB2 IGFBP3 JUN KRT14
4 embryo MP:0005380 10.01 CDH1 CDX2 ERBB2 JUN KRT18 PDPK1
5 integument MP:0010771 9.91 CDH1 ERBB2 IGFBP3 JUN KRT14 KRT5
6 limbs/digits/tail MP:0005371 9.7 CDX2 ERBB2 IGFBP3 JUN KRT5 PDPK1
7 neoplasm MP:0002006 9.5 CDH1 CDX2 ERBB2 KRT14 PDPK1 SHC1
8 normal MP:0002873 9.17 CDH1 CDX2 ERBB2 JUN PDPK1 SHC1

Drugs & Therapeutics for Esophageal Adenosquamous Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Adenosquamous Carcinoma

Genetic Tests for Esophageal Adenosquamous Carcinoma

Anatomical Context for Esophageal Adenosquamous Carcinoma

MalaCards organs/tissues related to Esophageal Adenosquamous Carcinoma:

40
Breast, Colon, Lung, Skin, Ovary, Thymus, Appendix

Publications for Esophageal Adenosquamous Carcinoma

Articles related to Esophageal Adenosquamous Carcinoma:

# Title Authors PMID Year
1
Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma. 61
30516569 2019
2
Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection. 61
31097930 2019
3
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. 61
29085501 2017
4
Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor. 61
28848104 2017
5
Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases. 61
24127755 2014
6
[Clinical analysis of 36 cases of esophageal mucoepidermoid carcinoma]. 61
22780981 2012
7
Primary mucoepidermoid carcinoma of the esophagus. 61
21587086 2011
8
[Clinical analysis of 22 cases of esophageal adenosquamous carcinoma]. 61
19615289 2009
9
[A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]. 61
16410703 2006
10
Esophageal adenosquamous carcinoma in a cat. 61
11217072 2001

Variations for Esophageal Adenosquamous Carcinoma

Expression for Esophageal Adenosquamous Carcinoma

Search GEO for disease gene expression data for Esophageal Adenosquamous Carcinoma.

Pathways for Esophageal Adenosquamous Carcinoma

Pathways related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 SHC1 KRT7 KRT5 KRT18 KRT14 JUN
2
Show member pathways
12.7 TP53 SHC1 PDPK1 JUN ERBB2
3
Show member pathways
12.6 TP53 SHC1 PDPK1 JUN ERBB2 CDH1
4
Show member pathways
12.49 TP53 SHC1 PDPK1 ERBB2
5
Show member pathways
12.47 TP53 SHC1 JUN ERBB2 CDX2 CDH1
6 12.43 KRT7 KRT5 KRT18 CDH1
7
Show member pathways
12.4 TP53 SHC1 JUN ERBB2
8
Show member pathways
12.39 KRT7 KRT5 KRT18 KRT14
9
Show member pathways
12.36 TP53 SHC1 PDPK1 JUN ERBB2 CDH1
10
Show member pathways
12.34 TP53 PDPK1 JUN ERBB2
11
Show member pathways
12.26 TP53 SHC1 PDPK1 IGFBP3
12
Show member pathways
12.23 TP53 SHC1 PDPK1 JUN ERBB2 CDH1
13
Show member pathways
12.21 TP53 SHC1 PDPK1 JUN
14
Show member pathways
12.11 TP53 SHC1 PDPK1 JUN CDH1
15 12.07 SHC1 PDPK1 JUN ERBB2
16
Show member pathways
12.03 SHC1 PDPK1 JUN ERBB2
17 11.97 TP53 SHC1 JUN
18 11.97 TP53 JUN IGFBP3
19 11.96 SHC1 KRT18 KRT14 JUN
20
Show member pathways
11.94 SHC1 PDPK1 JUN
21 11.93 PDPK1 JUN CDH1
22
Show member pathways
11.93 TP53 JUN ERBB2
23 11.85 TP53 JUN IGFBP3
24 11.84 TP53 SHC1 JUN ERBB2
25 11.8 SHC1 PDPK1 JUN
26
Show member pathways
11.79 KRT7 KRT5 KRT18 KRT14
27
Show member pathways
11.71 SHC1 PDPK1 JUN ERBB2 CDH1
28 11.7 TP53 SHC1 JUN
29 11.63 TP53 PDPK1 ERBB2
30 11.62 TP53 ERBB2 CDH1
31 11.62 TP53 KRT5 KRT14 JUN
32 11.58 SHC1 JUN ERBB2
33
Show member pathways
11.49 SHC1 PDPK1 JUN ERBB2
34 11.26 SHC1 JUN ERBB2
35 11.18 SHC1 ERBB2 CDH1
36
Show member pathways
11.13 SHC1 PDPK1 JUN
37 10.6 SHC1 PDPK1 JUN CDH1

GO Terms for Esophageal Adenosquamous Carcinoma

Cellular components related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.85 TP53 SHC1 PDPK1 PDK2 KRT7 KRT5
2 intermediate filament GO:0005882 9.26 KRT7 KRT5 KRT18 KRT14
3 keratin filament GO:0045095 8.92 KRT7 KRT5 KRT18 KRT14

Biological processes related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.72 TP53 SHC1 JUN CDX2 CDH1
2 positive regulation of MAPK cascade GO:0043410 9.54 SHC1 IGFBP3 ERBB2
3 Ras protein signal transduction GO:0007265 9.33 TP53 SHC1 JUN
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 keratinization GO:0031424 9.26 KRT7 KRT5 KRT18 KRT14
6 cornification GO:0070268 8.92 KRT7 KRT5 KRT18 KRT14

Sources for Esophageal Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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