MCID: ESP006
MIFTS: 28

Esophageal Adenosquamous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Adenosquamous Carcinoma

MalaCards integrated aliases for Esophageal Adenosquamous Carcinoma:

Name: Esophageal Adenosquamous Carcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5625
NCIt 51 C27421
UMLS 74 C2063886

Summaries for Esophageal Adenosquamous Carcinoma

Disease Ontology : 12 An esophageal carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Esophageal Adenosquamous Carcinoma is related to adenosquamous carcinoma and malignant acrospiroma. An important gene associated with Esophageal Adenosquamous Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and Endometrial cancer. Affiliated tissues include breast, lung and colon, and related phenotype is integument.

Related Diseases for Esophageal Adenosquamous Carcinoma

Diseases related to Esophageal Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 10.3
2 malignant acrospiroma 10.2 CEACAM5 KRT5
3 malignant spiradenoma 10.2 CEACAM5 KRT5
4 bile duct mucoepidermoid carcinoma 10.2 CEACAM5 KRT5
5 malignant biphasic mesothelioma 10.1 CEACAM5 KRT5
6 prostate squamous cell carcinoma 10.1 CEACAM5 KRT5
7 meibomian cyst 10.1 CEACAM5 JUN
8 large cell carcinoma 10.1 CEACAM5 KRT5
9 lymphoepithelioma-like carcinoma 10.1 CDH1 KRT5
10 oropharynx cancer 10.0 CDH1 KRT5
11 gastric signet ring cell adenocarcinoma 10.0 CDH1 CEACAM5
12 spindle cell carcinoma 10.0 CDH1 KRT5
13 infiltrative basal cell carcinoma 10.0 CDH1 CEACAM5
14 chondroid chordoma 10.0 CDH1 CEACAM5
15 squamous cell carcinoma 10.0
16 adenoid squamous cell carcinoma 10.0
17 bile duct adenocarcinoma 10.0 CDH1 CEACAM5
18 breast metaplastic carcinoma 10.0 ERBB2 KRT5
19 apocrine adenocarcinoma 10.0 ERBB2 KRT5
20 breast squamous cell carcinoma 10.0 ERBB2 KRT5
21 colonic disease 10.0 CDH1 CEACAM5
22 colorectal adenocarcinoma 10.0 CDH1 CEACAM5
23 breast benign neoplasm 9.9 ERBB2 KRT5
24 thoracic benign neoplasm 9.9 ERBB2 KRT5
25 intracystic papillary adenoma 9.9 CEACAM5 ERBB2
26 gallbladder squamous cell carcinoma 9.9 CEACAM5 ERBB2
27 breast secretory carcinoma 9.9 ERBB2 KRT5
28 mucoepidermoid carcinoma 9.9 CEACAM5 ERBB2
29 hidradenocarcinoma 9.9 ERBB2 KRT5
30 vulval paget's disease 9.9 CEACAM5 ERBB2
31 vulva adenocarcinoma 9.9 CEACAM5 ERBB2
32 breast carcinoma in situ 9.9 ERBB2 KRT5
33 sweat gland cancer 9.9 ERBB2 KRT5
34 mixed cell type cancer 9.9 CEACAM5 ERBB2
35 ovary adenocarcinoma 9.9 CEACAM5 ERBB2
36 esophageal disease 9.9 CEACAM5 ERBB2
37 intestinal disease 9.9 CDH1 CEACAM5
38 inflammatory breast carcinoma 9.9 CDH1 ERBB2
39 lobular neoplasia 9.9 CDH1 ERBB2
40 cystadenocarcinoma 9.9 CEACAM5 ERBB2
41 tubular adenocarcinoma 9.8 CDH1 ERBB2
42 respiratory system disease 9.8 CDH1 CEACAM5
43 breast adenomyoepithelioma 9.8 CDH1 CEACAM5 KRT5
44 breast myoepithelial neoplasm 9.8 CDH1 CEACAM5 KRT5
45 uterine anomalies 9.8 CDH1 ERBB2
46 bladder disease 9.8 CDH1 ERBB2
47 female reproductive system disease 9.8 CDH1 ERBB2
48 reproductive system disease 9.8 CDH1 ERBB2
49 colon adenocarcinoma 9.8 CDH1 CEACAM5 JUN
50 papillary carcinoma 9.8 CDH1 ERBB2

Graphical network of the top 20 diseases related to Esophageal Adenosquamous Carcinoma:



Diseases related to Esophageal Adenosquamous Carcinoma

Symptoms & Phenotypes for Esophageal Adenosquamous Carcinoma

MGI Mouse Phenotypes related to Esophageal Adenosquamous Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 CDH1 ERBB2 JUN KRT5

Drugs & Therapeutics for Esophageal Adenosquamous Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Adenosquamous Carcinoma

Genetic Tests for Esophageal Adenosquamous Carcinoma

Anatomical Context for Esophageal Adenosquamous Carcinoma

MalaCards organs/tissues related to Esophageal Adenosquamous Carcinoma:

42
Breast, Lung, Colon, Ovary, Kidney, Bone, Pancreas

Publications for Esophageal Adenosquamous Carcinoma

Articles related to Esophageal Adenosquamous Carcinoma:

# Title Authors Year
1
Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection. ( 31097930 )
2019
2
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. ( 29085501 )
2017
3
Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases. ( 24127755 )
2014
4
Esophageal adenosquamous carcinoma in a cat. ( 11217072 )
2001

Variations for Esophageal Adenosquamous Carcinoma

Expression for Esophageal Adenosquamous Carcinoma

Search GEO for disease gene expression data for Esophageal Adenosquamous Carcinoma.

Pathways for Esophageal Adenosquamous Carcinoma

Pathways related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 CDH1 ERBB2 JUN
2
Show member pathways
12.47 CDH1 ERBB2 JUN
3 12.41 CDH1 ERBB2 JUN
4
Show member pathways
12.21 CDH1 ERBB2 JUN
5
Show member pathways
12.18 CDH1 ERBB2 JUN
6
Show member pathways
12.06 CDH1 ERBB2 JUN
7
Show member pathways
11.91 CDH1 ERBB2 JUN
8 11.69 CDH1 CEACAM5
9 11.69 CDH1 JUN
10
Show member pathways
11.68 ERBB2 JUN
11 11.63 ERBB2 JUN
12
Show member pathways
11.62 CDH1 ERBB2 JUN
13 11.47 JUN KRT5
14 11.42 CDH1 JUN
15 11.36 CDH1 ERBB2
16 11.33 CDH1 ERBB2
17 11.29 ERBB2 JUN
18
Show member pathways
11.27 ERBB2 JUN
19 11.08 ERBB2 JUN
20 10.83 CDH1 JUN
21 10.62 CDH1 ERBB2 JUN
22 10.11 CDH1 ERBB2

GO Terms for Esophageal Adenosquamous Carcinoma

Biological processes related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 8.96 CDH1 JUN
2 negative regulation of apoptotic process GO:0043066 8.62 CEACAM5 JUN

Molecular functions related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 CDH1 CEACAM5 ERBB2 JUN

Sources for Esophageal Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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