MCID: ESP006
MIFTS: 27

Esophageal Adenosquamous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Adenosquamous Carcinoma

MalaCards integrated aliases for Esophageal Adenosquamous Carcinoma:

Name: Esophageal Adenosquamous Carcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5625
NCIt 49 C27421
UMLS 71 C2063886

Summaries for Esophageal Adenosquamous Carcinoma

Disease Ontology : 12 An esophageal carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Esophageal Adenosquamous Carcinoma is related to adenosquamous carcinoma and esophageal disease. An important gene associated with Esophageal Adenosquamous Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Endometrial cancer. Affiliated tissues include liver, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Esophageal Adenosquamous Carcinoma

Diseases related to Esophageal Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 31.1 KRT7 KRT5 CEACAM5
2 esophageal disease 29.7 ERBB2 CEACAM5 CDH1
3 esophageal cancer 29.0 JUN IGFBP3 ERBB2 CEACAM5 CDX2 CDH1
4 papillary adenoma 10.5 KRT7 KRT5
5 inverted transitional papilloma 10.5 KRT7 KRT5
6 ceruminoma 10.5 KRT7 KRT5
7 bladder signet ring cell adenocarcinoma 10.5 KRT7 CDX2
8 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
9 benign breast adenomyoepithelioma 10.5 KRT7 KRT5
10 breast adenomyoepithelioma 10.5 KRT7 KRT5
11 subareolar duct papillomatosis 10.5 KRT7 KRT5
12 anal canal paget's disease 10.5 KRT7 CDX2
13 bone leiomyosarcoma 10.5 KRT7 KRT5
14 nipple neoplasm 10.5 KRT7 KRT5
15 microinvasive cervical squamous cell carcinoma 10.5 KRT7 KRT5
16 gastric signet ring cell adenocarcinoma 10.5 KRT7 CDX2
17 adenosquamous colon carcinoma 10.5 KRT7 CDX2
18 nasal cavity adenocarcinoma 10.5 KRT7 CDX2
19 anus adenocarcinoma 10.5 KRT7 CDX2
20 ceruminous adenocarcinoma 10.5 KRT7 KRT5
21 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
22 cystitis cystica 10.5 KRT7 CDX2
23 ovarian seromucinous carcinoma 10.5 KRT7 CDX2
24 gastric squamous cell carcinoma 10.5 KRT7 KRT5
25 middle ear adenoma 10.5 KRT7 KRT5
26 breast myoepithelial neoplasm 10.5 KRT7 KRT5
27 ovarian cystadenoma 10.5 KRT7 CEACAM5
28 anal canal adenocarcinoma 10.5 KRT7 CDX2
29 necrotizing sialometaplasia 10.5 KRT7 KRT5
30 sensory organ benign neoplasm 10.5 KRT7 KRT5
31 mucoepidermoid esophageal carcinoma 10.5 KRT5 CEACAM5
32 jejunal cancer 10.5 KRT7 CDX2
33 middle ear adenocarcinoma 10.5 KRT7 KRT5
34 metatypical basal cell carcinoma 10.5 KRT7 KRT5
35 malignant acrospiroma 10.4 KRT5 CEACAM5
36 gallbladder squamous cell carcinoma 10.4 KRT5 CEACAM5
37 nephrogenic adenoma of the urethra 10.4 KRT7 KRT5
38 laryngeal small cell carcinoma 10.4 KRT7 KRT5
39 papillary squamous carcinoma 10.4 KRT7 KRT5
40 malignant epithelial mesothelioma 10.4 KRT5 CEACAM5
41 large cell acanthoma 10.4 KRT7 KRT5
42 glandular cystitis 10.4 KRT7 CDX2
43 benign mesenchymoma 10.4 KRT7 KRT5
44 urethral villous adenoma 10.4 KRT7 CEACAM5
45 balloon cell malignant melanoma 10.4 KRT7 KRT5
46 mucinous stomach adenocarcinoma 10.4 KRT7 CDX2
47 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
48 seminal vesicle adenocarcinoma 10.4 KRT7 CEACAM5
49 lung clear cell carcinoma 10.4 KRT7 KRT5
50 descending colon cancer 10.4 CEACAM5 CDX2

Graphical network of the top 20 diseases related to Esophageal Adenosquamous Carcinoma:



Diseases related to Esophageal Adenosquamous Carcinoma

Symptoms & Phenotypes for Esophageal Adenosquamous Carcinoma

GenomeRNAi Phenotypes related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CDH1 IGFBP3 JUN KRT7 PDPK1 SHC1

MGI Mouse Phenotypes related to Esophageal Adenosquamous Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 CANX CDH1 CDX2 ERBB2 HGD IGFBP3
2 endocrine/exocrine gland MP:0005379 9.92 CDH1 CDX2 ERBB2 IGFBP3 JUN PDPK1
3 integument MP:0010771 9.76 CDH1 ERBB2 IGFBP3 JUN KRT5 PDPK1
4 limbs/digits/tail MP:0005371 9.43 CDX2 ERBB2 IGFBP3 KRT5 PDPK1 SP6
5 normal MP:0002873 9.17 CDH1 CDX2 ERBB2 JUN PDPK1 SHC1

Drugs & Therapeutics for Esophageal Adenosquamous Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Adenosquamous Carcinoma

Genetic Tests for Esophageal Adenosquamous Carcinoma

Anatomical Context for Esophageal Adenosquamous Carcinoma

MalaCards organs/tissues related to Esophageal Adenosquamous Carcinoma:

40
Liver

Publications for Esophageal Adenosquamous Carcinoma

Articles related to Esophageal Adenosquamous Carcinoma:

# Title Authors PMID Year
1
Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma. 61
30516569 2019
2
Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection. 61
31097930 2019
3
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. 61
29085501 2017
4
Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor. 61
28848104 2017
5
Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases. 61
24127755 2014
6
[Clinical analysis of 36 cases of esophageal mucoepidermoid carcinoma]. 61
22780981 2012
7
Primary mucoepidermoid carcinoma of the esophagus. 61
21587086 2011
8
[Clinical analysis of 22 cases of esophageal adenosquamous carcinoma]. 61
19615289 2009
9
[A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]. 61
16410703 2006
10
Esophageal adenosquamous carcinoma in a cat. 61
11217072 2001

Variations for Esophageal Adenosquamous Carcinoma

Expression for Esophageal Adenosquamous Carcinoma

Search GEO for disease gene expression data for Esophageal Adenosquamous Carcinoma.

Pathways for Esophageal Adenosquamous Carcinoma

Pathways related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 SHC1 PDPK1 JUN IGFBP3 ERBB2
2
Show member pathways
12.64 SHC1 PDPK1 JUN ERBB2 CDH1
3
Show member pathways
12.52 SHC1 JUN ERBB2 CDX2 CDH1
4
Show member pathways
12.46 SHC1 PDPK1 JUN ERBB2 CDH1
5
Show member pathways
12.36 SHC1 PDPK1 JUN ERBB2 CDH1
6 11.92 SHC1 PDPK1 JUN ERBB2
7 11.91 SHC1 PDPK1 JUN
8
Show member pathways
11.85 SHC1 PDPK1 JUN ERBB2 CDH1
9
Show member pathways
11.84 SHC1 PDPK1 JUN
10 11.82 PDPK1 JUN CDH1
11
Show member pathways
11.8 SHC1 PDPK1 JUN ERBB2
12 11.78 SHC1 JUN ERBB2
13 11.69 SHC1 PDPK1 JUN
14 11.49 SHC1 JUN ERBB2
15
Show member pathways
11.15 SHC1 PDPK1 JUN ERBB2
16
Show member pathways
11.02 SHC1 PDPK1 JUN
17 10.93 SHC1 JUN
18 10.92 SHC1 ERBB2 CDH1
19 10.6 SHC1 PDPK1 JUN CDH1

GO Terms for Esophageal Adenosquamous Carcinoma

Biological processes related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 8.8 SHC1 IGFBP3 ERBB2

Molecular functions related to Esophageal Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 8.62 SHC1 PDPK1

Sources for Esophageal Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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