MCID: ESP010
MIFTS: 39

Esophageal Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Esophageal Basaloid Squamous Cell Carcinoma:

Name: Esophageal Basaloid Squamous Cell Carcinoma 12 15
Basaloid Squamous Carcinoma of Esophagus 12
Esophageal Basaloid Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7051
NCIt 50 C7032
UMLS 73 C1333443

Summaries for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards based summary : Esophageal Basaloid Squamous Cell Carcinoma, also known as basaloid squamous carcinoma of esophagus, is related to basaloid squamous cell carcinoma and squamous cell carcinoma, and has symptoms including pain and regurgitation. An important gene associated with Esophageal Basaloid Squamous Cell Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Signaling by GPCR and PI3K-Akt signaling pathway. Affiliated tissues include brain, colon and lymph node, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Esophageal Basaloid Squamous Cell Carcinoma

Diseases related to Esophageal Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.0 EGFR KRT14 TP53
2 squamous cell carcinoma 30.9 CTNNB1 EGFR TP53 WWOX
3 brain ependymoma 10.3 EGFR TP53
4 benign breast adenomyoepithelioma 10.2 EGFR KRT14
5 oncocytic breast carcinoma 10.2 EGFR KRT14
6 fibroepithelial basal cell carcinoma 10.2 KRT14 TP53
7 lymph node cancer 10.2 TP53 WWOX
8 microglandular adenosis 10.2 EGFR TP53
9 spiradenoma 10.2 KRT14 TP53
10 pleomorphic carcinoma 10.2 EGFR TP53
11 hair follicle neoplasm 10.2 CTNNB1 KRT14
12 esophageal disease 10.2 EGFR TP53 WWOX
13 female reproductive endometrioid cancer 10.2 CTNNB1 TP53
14 breast squamous cell carcinoma 10.2 EGFR KRT14 TP53
15 pulmonary blastoma 10.1 EGFR TP53
16 pre-malignant neoplasm 10.1 EGFR KRT14 TP53
17 oropharynx cancer 10.1 EGFR KRT14 TP53
18 in situ carcinoma 10.1 EGFR KRT14 TP53
19 ductal carcinoma in situ 10.1 EGFR KRT14 TP53
20 gliomatosis cerebri 10.1 EGFR TP53
21 pharynx cancer 10.1 CTNNB1 EGFR TP53
22 colonic disease 10.1 CTNNB1 EGFR TP53
23 colorectal adenocarcinoma 10.1 CTNNB1 EGFR TP53
24 female reproductive system disease 10.1 CTNNB1 EGFR TP53
25 reproductive system disease 10.1 CTNNB1 EGFR TP53
26 respiratory system cancer 10.1 CTNNB1 EGFR TP53
27 endometrial adenocarcinoma 10.1 CTNNB1 EGFR TP53
28 intrahepatic cholangiocarcinoma 10.1 CTNNB1 EGFR TP53
29 uterine carcinosarcoma 10.1 CTNNB1 EGFR TP53
30 breast ductal carcinoma 10.1 CTNNB1 EGFR TP53
31 squamous cell papilloma 10.1 SFRP4 TP53 WWOX
32 soft tissue sarcoma 10.1 EGFR TP53
33 intestinal disease 10.1 CTNNB1 EGFR TP53
34 endocrine gland cancer 10.1 CTNNB1 EGFR TP53
35 pancreas adenocarcinoma 10.1 CTNNB1 EGFR TP53
36 lynch syndrome 10.1 CTNNB1 EGFR TP53
37 breast benign neoplasm 10.0 KRT14 TP53
38 stomach disease 10.0 CTNNB1 EGFR TP53 WWOX
39 gastrointestinal system cancer 10.0 CTNNB1 EGFR TP53 WWOX
40 adenoma 10.0 AXIN2 CTNNB1 TP53
41 gastrointestinal system disease 10.0 CTNNB1 EGFR TP53 WWOX
42 adult hepatocellular carcinoma 10.0 AXIN1 CTNNB1 TP53
43 embryonal sarcoma 10.0 AXIN1 CTNNB1 TP53
44 thoracic benign neoplasm 10.0 KRT14 TP53
45 brain cancer 9.9 AXIN1 CTNNB1 EGFR TP53
46 medulloblastoma 9.8 AXIN1 CTNNB1 EGFR TP53
47 familial adenomatous polyposis 9.8 AXIN1 AXIN2 CTNNB1 TP53
48 large intestine cancer 9.2 AXIN1 AXIN2 CTNNB1 EGFR SFRP1 SFRP2

Graphical network of the top 20 diseases related to Esophageal Basaloid Squamous Cell Carcinoma:



Diseases related to Esophageal Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Esophageal Basaloid Squamous Cell Carcinoma

UMLS symptoms related to Esophageal Basaloid Squamous Cell Carcinoma:


pain, regurgitation

MGI Mouse Phenotypes related to Esophageal Basaloid Squamous Cell Carcinoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 AXIN1 AXIN2 CTNNB1 DACT1 EGFR KRT14
2 mortality/aging MP:0010768 10.27 AXIN1 AXIN2 CTNNB1 DACT1 EGFR KRT14
3 cardiovascular system MP:0005385 10.22 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
4 limbs/digits/tail MP:0005371 10.22 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB
5 embryo MP:0005380 10.19 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
6 endocrine/exocrine gland MP:0005379 10.18 AXIN2 CTNNB1 EGFR KRT14 SFRP1 SFRP2
7 craniofacial MP:0005382 10.16 AXIN1 AXIN2 CTNNB1 EGFR KRT14 SFRP1
8 nervous system MP:0003631 10.14 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB
9 digestive/alimentary MP:0005381 10.09 AXIN1 CTNNB1 DACT1 EGFR KRT14 SFRP4
10 no phenotypic analysis MP:0003012 9.97 AXIN2 CTNNB1 DACT1 EGFR SFRP1 SFRP2
11 reproductive system MP:0005389 9.93 AXIN1 AXIN2 CTNNB1 DACT1 EGFR KRT14
12 normal MP:0002873 9.92 AXIN1 AXIN2 CTNNB1 EGFR FRZB SFRP2
13 neoplasm MP:0002006 9.91 CTNNB1 EGFR KRT14 TP53 WIF1 WWOX
14 hearing/vestibular/ear MP:0005377 9.89 AXIN1 CTNNB1 EGFR KRT14 TP53
15 renal/urinary system MP:0005367 9.73 AXIN1 CTNNB1 DACT1 EGFR SFRP4 TP53
16 respiratory system MP:0005388 9.43 AXIN1 CTNNB1 EGFR KRT14 SFRP4 TP53
17 skeleton MP:0005390 9.36 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB

Drugs & Therapeutics for Esophageal Basaloid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Basaloid Squamous Cell Carcinoma

Genetic Tests for Esophageal Basaloid Squamous Cell Carcinoma

Anatomical Context for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Esophageal Basaloid Squamous Cell Carcinoma:

41
Brain, Colon, Lymph Node, Tongue, Breast, Tonsil, Pancreas

Publications for Esophageal Basaloid Squamous Cell Carcinoma

Articles related to Esophageal Basaloid Squamous Cell Carcinoma:

# Title Authors Year
1
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
2
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
3
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
4
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
5
Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. ( 22607702 )
2012
6
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. ( 10885705 )
2000

Variations for Esophageal Basaloid Squamous Cell Carcinoma

Expression for Esophageal Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Basaloid Squamous Cell Carcinoma.

Pathways for Esophageal Basaloid Squamous Cell Carcinoma

Pathways related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
2
Show member pathways
12.86 AXIN1 AXIN2 CTNNB1 EGFR TP53
3
Show member pathways
12.73 AXIN1 AXIN2 CTNNB1 EGFR TP53
4 12.69 AXIN1 AXIN2 CTNNB1 EGFR TP53
5
Show member pathways
12.62 AXIN1 AXIN2 CTNNB1 EGFR TP53
6
Show member pathways
12.46 AXIN1 AXIN2 CTNNB1 DACT1 SFRP1 SFRP2
7
Show member pathways
12.39 AXIN1 AXIN2 CTNNB1 SFRP1
8
Show member pathways
12.36 AXIN1 AXIN2 EGFR TP53
9
Show member pathways
12.3 AXIN1 AXIN2 CTNNB1 EGFR
10 12.2 AXIN1 CTNNB1 FRZB TP53 WIF1
11
Show member pathways
12.12 AXIN1 AXIN2 CTNNB1 SFRP1 SFRP2 SFRP4
12 12.04 AXIN2 CTNNB1 EGFR TP53
13 12.01 AXIN1 AXIN2 CTNNB1
14 12.01 CTNNB1 EGFR TP53
15 11.96 AXIN1 AXIN2 CTNNB1
16 11.93 CTNNB1 FRZB SFRP4
17 11.92 AXIN1 CTNNB1 TP53
18 11.91 AXIN1 AXIN2 CTNNB1 SFRP1 WIF1
19 11.86 AXIN1 CTNNB1 TP53
20
Show member pathways
11.82 AXIN1 CTNNB1 FRZB TP53 WIF1
21 11.8 AXIN1 AXIN2 CTNNB1
22 11.8 AXIN1 CTNNB1 EGFR TP53
23 11.58 AXIN1 CTNNB1 EGFR
24 11.56 AXIN1 CTNNB1 TP53
25
Show member pathways
11.5 AXIN1 AXIN2 CTNNB1 FRZB SFRP1 SFRP2
26 11.45 AXIN1 AXIN2 CTNNB1
27 11.38 AXIN1 CTNNB1 WIF1
28 11.2 CTNNB1 EGFR TP53
29 11.13 AXIN1 CTNNB1 EGFR
30 10.99 AXIN2 CTNNB1 WIF1
31
Show member pathways
10.87 SFRP1 SFRP2 WIF1
32 10.75 AXIN1 CTNNB1 SFRP4
33 10.74 CTNNB1 SFRP1

GO Terms for Esophageal Basaloid Squamous Cell Carcinoma

Cellular components related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.13 AXIN1 CTNNB1 KRT14
2 beta-catenin destruction complex GO:0030877 8.92 AXIN1 AXIN2 CTNNB1 DACT1

Biological processes related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.97 AXIN2 CTNNB1 EGFR TP53
2 positive regulation of apoptotic process GO:0043065 9.97 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 TP53
3 canonical Wnt signaling pathway GO:0060070 9.88 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 SFRP5
4 negative regulation of cell growth GO:0030308 9.84 FRZB SFRP1 SFRP2 TP53
5 regulation of Wnt signaling pathway GO:0030111 9.83 AXIN1 AXIN2 DACT1 SFRP2 SFRP5
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 AXIN1 EGFR SFRP2
7 positive regulation of fat cell differentiation GO:0045600 9.81 FRZB SFRP1 SFRP2 WIF1
8 positive regulation of cell growth GO:0030307 9.8 EGFR SFRP1 SFRP2
9 positive regulation of canonical Wnt signaling pathway GO:0090263 9.8 AXIN1 AXIN2 DACT1 EGFR SFRP1 SFRP2
10 cellular response to growth factor stimulus GO:0071363 9.79 CTNNB1 EGFR SFRP1
11 somitogenesis GO:0001756 9.78 AXIN2 SFRP1 SFRP2
12 non-canonical Wnt signaling pathway GO:0035567 9.77 FRZB SFRP1 SFRP2 SFRP4 SFRP5
13 negative regulation of canonical Wnt signaling pathway GO:0090090 9.76 AXIN1 AXIN2 DACT1 FRZB SFRP1 SFRP2
14 neural tube development GO:0021915 9.75 DACT1 SFRP1 SFRP2
15 digestive tract morphogenesis GO:0048546 9.7 EGFR SFRP1 SFRP2
16 Wnt signaling pathway GO:0016055 9.7 AXIN1 AXIN2 CTNNB1 DACT1 FRZB SFRP1
17 negative regulation of epithelial to mesenchymal transition GO:0010719 9.68 SFRP1 SFRP2
18 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.68 SFRP1 WWOX
19 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.68 TP53 WWOX
20 negative regulation of osteoclast differentiation GO:0045671 9.67 CTNNB1 SFRP1
21 beta-catenin destruction complex disassembly GO:1904886 9.67 AXIN1 CTNNB1
22 negative regulation of JUN kinase activity GO:0043508 9.66 SFRP1 SFRP2
23 negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 9.65 SFRP1 SFRP2
24 planar cell polarity pathway involved in neural tube closure GO:0090179 9.65 SFRP1 SFRP2
25 cellular response to X-ray GO:0071481 9.64 SFRP1 SFRP2
26 regulation of BMP signaling pathway GO:0030510 9.64 SFRP4 SFRP5
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.62 EGFR TP53
28 dorsal/ventral axis specification GO:0009950 9.62 CTNNB1 SFRP1
29 development of primary male sexual characteristics GO:0046546 9.6 SFRP1 SFRP2
30 regulation of establishment of planar polarity GO:0090175 9.59 SFRP1 SFRP2
31 Wnt signaling pathway involved in somitogenesis GO:0090244 9.58 SFRP1 SFRP2
32 regulation of centromeric sister chromatid cohesion GO:0070602 9.57 AXIN2 CTNNB1
33 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 9.56 SFRP1 SFRP2
34 regulation of midbrain dopaminergic neuron differentiation GO:1904956 9.55 SFRP1 SFRP2
35 negative regulation of Wnt signaling pathway GO:0030178 9.23 DACT1 FRZB SFRP1 SFRP2 SFRP4 SFRP5
36 cell differentiation GO:0030154 10.08 CTNNB1 EGFR FRZB SFRP1 SFRP2 SFRP4
37 apoptotic process GO:0006915 10.06 AXIN1 SFRP2 SFRP5 TP53 WWOX
38 negative regulation of cell proliferation GO:0008285 10.06 AXIN2 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
39 multicellular organism development GO:0007275 10.06 AXIN1 AXIN2 DACT1 EGFR FRZB SFRP1
40 positive regulation of transcription, DNA-templated GO:0045893 10.04 AXIN1 CTNNB1 EGFR SFRP1 TP53

Molecular functions related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.73 AXIN1 CTNNB1 EGFR TP53
2 ubiquitin protein ligase binding GO:0031625 9.71 AXIN1 AXIN2 EGFR TP53
3 beta-catenin binding GO:0008013 9.54 AXIN1 AXIN2 DACT1
4 protein phosphatase binding GO:0019903 9.5 CTNNB1 EGFR TP53
5 RNA polymerase II transcription factor binding GO:0001085 9.43 CTNNB1 DACT1 TP53
6 enzyme binding GO:0019899 9.43 AXIN1 AXIN2 CTNNB1 EGFR TP53 WWOX
7 I-SMAD binding GO:0070411 9.33 AXIN1 AXIN2 CTNNB1
8 Wnt-protein binding GO:0017147 9.1 FRZB SFRP1 SFRP2 SFRP4 SFRP5 WIF1

Sources for Esophageal Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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