MCID: ESP010
MIFTS: 36

Esophageal Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Esophageal Basaloid Squamous Cell Carcinoma:

Name: Esophageal Basaloid Squamous Cell Carcinoma 12 15
Basaloid Squamous Carcinoma of Esophagus 12
Esophageal Basaloid Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7051
NCIt 51 C7032
UMLS 74 C1333443

Summaries for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards based summary : Esophageal Basaloid Squamous Cell Carcinoma, also known as basaloid squamous carcinoma of esophagus, is related to basaloid squamous cell carcinoma and squamous cell carcinoma, and has symptoms including pain and regurgitation. An important gene associated with Esophageal Basaloid Squamous Cell Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Signaling by GPCR and PI3K-Akt signaling pathway. Affiliated tissues include neutrophil, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Esophageal Basaloid Squamous Cell Carcinoma

Diseases related to Esophageal Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.2 EGFR KRT14 TP53
2 squamous cell carcinoma 10.5
3 brain ependymoma 10.4 EGFR TP53
4 benign breast adenomyoepithelioma 10.3 EGFR KRT14
5 recurrent respiratory papillomatosis 10.3 EGFR TP53
6 oncocytic breast carcinoma 10.3 EGFR KRT14
7 fibroepithelial basal cell carcinoma 10.3 KRT14 TP53
8 microglandular adenosis 10.3 EGFR TP53
9 spiradenoma 10.3 KRT14 TP53
10 pleomorphic carcinoma 10.2 EGFR TP53
11 hair follicle neoplasm 10.2 CTNNB1 KRT14
12 breast squamous cell carcinoma 10.2 EGFR KRT14 TP53
13 pre-malignant neoplasm 10.2 EGFR KRT14 TP53
14 female reproductive endometrioid cancer 10.2 CTNNB1 TP53
15 oropharynx cancer 10.2 EGFR KRT14 TP53
16 pulmonary blastoma 10.2 EGFR TP53
17 in situ carcinoma 10.2 EGFR KRT14 TP53
18 ductal carcinoma in situ 10.2 EGFR KRT14 TP53
19 pharynx cancer 10.2 CTNNB1 EGFR TP53
20 colonic disease 10.2 CTNNB1 EGFR TP53
21 colorectal adenocarcinoma 10.2 CTNNB1 EGFR TP53
22 stomach disease 10.2 CTNNB1 EGFR TP53
23 gliomatosis cerebri 10.2 EGFR TP53
24 female reproductive system disease 10.2 CTNNB1 EGFR TP53
25 reproductive system disease 10.2 CTNNB1 EGFR TP53
26 respiratory system cancer 10.2 CTNNB1 EGFR TP53
27 endometrial adenocarcinoma 10.2 CTNNB1 EGFR TP53
28 intrahepatic cholangiocarcinoma 10.2 CTNNB1 EGFR TP53
29 uterine carcinosarcoma 10.2 CTNNB1 EGFR TP53
30 breast ductal carcinoma 10.2 CTNNB1 EGFR TP53
31 intestinal disease 10.2 CTNNB1 EGFR TP53
32 gastrointestinal system cancer 10.2 CTNNB1 EGFR TP53
33 soft tissue sarcoma 10.2 EGFR TP53
34 endocrine gland cancer 10.2 CTNNB1 EGFR TP53
35 gastrointestinal system disease 10.1 CTNNB1 EGFR TP53
36 pancreas adenocarcinoma 10.1 CTNNB1 EGFR TP53
37 lynch syndrome 10.1 CTNNB1 EGFR TP53
38 adenoma 10.1 AXIN2 CTNNB1 TP53
39 breast benign neoplasm 10.1 KRT14 TP53
40 adult hepatocellular carcinoma 10.1 AXIN1 CTNNB1 TP53
41 embryonal sarcoma 10.1 AXIN1 CTNNB1 TP53
42 thoracic benign neoplasm 10.0 KRT14 TP53
43 brain cancer 9.9 AXIN1 CTNNB1 EGFR TP53
44 familial adenomatous polyposis 9.8 AXIN1 AXIN2 CTNNB1 TP53
45 medulloblastoma 9.4 AXIN1 CTNNB1 DKK1 EGFR TP53
46 large intestine cancer 8.9 AXIN1 AXIN2 CTNNB1 EGFR SFRP1 SFRP2

Graphical network of the top 20 diseases related to Esophageal Basaloid Squamous Cell Carcinoma:



Diseases related to Esophageal Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Esophageal Basaloid Squamous Cell Carcinoma

UMLS symptoms related to Esophageal Basaloid Squamous Cell Carcinoma:


pain, regurgitation

MGI Mouse Phenotypes related to Esophageal Basaloid Squamous Cell Carcinoma:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
2 mortality/aging MP:0010768 10.25 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
3 limbs/digits/tail MP:0005371 10.23 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
4 embryo MP:0005380 10.22 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
5 cardiovascular system MP:0005385 10.21 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
6 craniofacial MP:0005382 10.2 AXIN1 AXIN2 CTNNB1 DKK1 EGFR KRT14
7 nervous system MP:0003631 10.14 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
8 endocrine/exocrine gland MP:0005379 10.11 AXIN2 CTNNB1 EGFR KRT14 SFRP1 SFRP2
9 digestive/alimentary MP:0005381 10.08 AXIN1 CTNNB1 DACT1 EGFR KRT14 SFRP4
10 normal MP:0002873 9.92 AXIN1 AXIN2 CTNNB1 EGFR FRZB SFRP2
11 no phenotypic analysis MP:0003012 9.91 AXIN2 CTNNB1 DACT1 EGFR SFRP1 SFRP2
12 reproductive system MP:0005389 9.9 AXIN1 AXIN2 CTNNB1 DACT1 EGFR KRT14
13 hearing/vestibular/ear MP:0005377 9.88 AXIN1 CTNNB1 EGFR KRT14 TP53
14 renal/urinary system MP:0005367 9.8 AXIN1 CTNNB1 DACT1 DKK1 EGFR SFRP4
15 respiratory system MP:0005388 9.5 AXIN1 CTNNB1 DKK1 EGFR KRT14 SFRP4
16 skeleton MP:0005390 9.36 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR

Drugs & Therapeutics for Esophageal Basaloid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Basaloid Squamous Cell Carcinoma

Genetic Tests for Esophageal Basaloid Squamous Cell Carcinoma

Anatomical Context for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Esophageal Basaloid Squamous Cell Carcinoma:

42
Neutrophil

Publications for Esophageal Basaloid Squamous Cell Carcinoma

Articles related to Esophageal Basaloid Squamous Cell Carcinoma:

# Title Authors Year
1
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
2
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
3
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
4
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
5
Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. ( 22607702 )
2012
6
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. ( 10885705 )
2000

Variations for Esophageal Basaloid Squamous Cell Carcinoma

Expression for Esophageal Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Basaloid Squamous Cell Carcinoma.

Pathways for Esophageal Basaloid Squamous Cell Carcinoma

Pathways related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
2
Show member pathways
12.86 AXIN1 AXIN2 CTNNB1 EGFR TP53
3
Show member pathways
12.74 AXIN1 AXIN2 CTNNB1 EGFR TP53
4 12.71 AXIN1 AXIN2 CTNNB1 EGFR TP53
5
Show member pathways
12.64 AXIN1 AXIN2 CTNNB1 EGFR TP53
6
Show member pathways
12.52 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 SFRP1
7
Show member pathways
12.4 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1
8
Show member pathways
12.38 AXIN1 AXIN2 EGFR TP53
9 12.28 AXIN1 CTNNB1 DKK1 FRZB TP53 WIF1
10 12.08 AXIN2 CTNNB1 EGFR TP53
11 12.03 AXIN1 AXIN2 CTNNB1
12 12.02 CTNNB1 EGFR TP53
13 11.99 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1 WIF1
14 11.97 AXIN1 AXIN2 CTNNB1
15 11.94 CTNNB1 FRZB SFRP4
16 11.93 AXIN1 CTNNB1 TP53
17 11.93 DKK1 EGFR TP53
18
Show member pathways
11.91 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1 SFRP2
19 11.86 AXIN1 CTNNB1 TP53
20 11.86 AXIN1 CTNNB1 EGFR TP53
21
Show member pathways
11.86 AXIN1 CTNNB1 DKK1 FRZB TP53 WIF1
22
Show member pathways
11.85 AXIN1 AXIN2 CTNNB1 DKK1 FRZB SFRP1
23 11.83 AXIN1 CTNNB1 DKK1
24 11.8 AXIN1 AXIN2 CTNNB1
25 11.68 AXIN2 CTNNB1 DKK1
26 11.6 AXIN1 CTNNB1 EGFR
27 11.57 AXIN1 CTNNB1 TP53
28 11.51 AXIN1 CTNNB1 DKK1
29 11.47 AXIN1 AXIN2 CTNNB1
30 11.4 AXIN1 CTNNB1 DKK1 WIF1
31 11.24 CTNNB1 EGFR TP53
32 11.19 AXIN1 CTNNB1 EGFR
33 11.05 AXIN2 CTNNB1 DKK1 WIF1
34
Show member pathways
10.94 DKK1 SFRP1 SFRP2 WIF1
35 10.93 AXIN1 CTNNB1 SFRP4
36 10.77 CTNNB1 DKK1 SFRP1

GO Terms for Esophageal Basaloid Squamous Cell Carcinoma

Cellular components related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 DKK1 EGFR FRZB SFRP1 SFRP2 SFRP4
2 cell periphery GO:0071944 9.13 AXIN1 CTNNB1 KRT14
3 beta-catenin destruction complex GO:0030877 8.92 AXIN1 AXIN2 CTNNB1 DACT1

Biological processes related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 CTNNB1 DKK1 SFRP4 TP53
2 positive regulation of apoptotic process GO:0043065 9.99 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 TP53
3 cell proliferation GO:0008283 9.98 AXIN2 CTNNB1 EGFR TP53
4 canonical Wnt signaling pathway GO:0060070 9.91 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 SFRP5
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.91 AXIN1 AXIN2 DACT1 EGFR SFRP1 SFRP2
6 Wnt signaling pathway GO:0016055 9.9 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 FRZB
7 negative regulation of cell growth GO:0030308 9.85 FRZB SFRP1 SFRP2 TP53
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 AXIN1 EGFR SFRP2
9 positive regulation of fat cell differentiation GO:0045600 9.83 FRZB SFRP1 SFRP2 WIF1
10 positive regulation of cell growth GO:0030307 9.82 EGFR SFRP1 SFRP2
11 cellular response to growth factor stimulus GO:0071363 9.8 CTNNB1 EGFR SFRP1
12 somitogenesis GO:0001756 9.8 AXIN2 SFRP1 SFRP2
13 non-canonical Wnt signaling pathway GO:0035567 9.8 FRZB SFRP1 SFRP2 SFRP4 SFRP5
14 regulation of Wnt signaling pathway GO:0030111 9.8 AXIN1 AXIN2 DACT1 DKK1 SFRP2 SFRP5
15 negative regulation of BMP signaling pathway GO:0030514 9.79 DKK1 SFRP1 SFRP2
16 neural tube development GO:0021915 9.76 DACT1 SFRP1 SFRP2
17 digestive tract morphogenesis GO:0048546 9.71 EGFR SFRP1 SFRP2
18 negative regulation of epithelial to mesenchymal transition GO:0010719 9.69 SFRP1 SFRP2
19 negative regulation of osteoclast differentiation GO:0045671 9.69 CTNNB1 SFRP1
20 beta-catenin destruction complex disassembly GO:1904886 9.68 AXIN1 CTNNB1
21 negative regulation of ossification GO:0030279 9.68 DKK1 SFRP1
22 negative regulation of JUN kinase activity GO:0043508 9.68 SFRP1 SFRP2
23 negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 9.67 SFRP1 SFRP2
24 planar cell polarity pathway involved in neural tube closure GO:0090179 9.67 SFRP1 SFRP2
25 cellular response to X-ray GO:0071481 9.66 SFRP1 SFRP2
26 endoderm formation GO:0001706 9.66 CTNNB1 DKK1
27 regulation of BMP signaling pathway GO:0030510 9.65 SFRP4 SFRP5
28 Wnt signaling pathway involved in somitogenesis GO:0090244 9.65 DKK1 SFRP1 SFRP2
29 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.64 EGFR TP53
30 dorsal/ventral axis specification GO:0009950 9.63 CTNNB1 SFRP1
31 cell morphogenesis involved in differentiation GO:0000904 9.62 CTNNB1 DKK1
32 development of primary male sexual characteristics GO:0046546 9.61 SFRP1 SFRP2
33 negative regulation of canonical Wnt signaling pathway GO:0090090 9.61 AXIN1 AXIN2 DACT1 DKK1 FRZB SFRP1
34 negative regulation of mesodermal cell fate specification GO:0042662 9.6 DKK1 SFRP2
35 regulation of establishment of planar polarity GO:0090175 9.59 SFRP1 SFRP2
36 regulation of centromeric sister chromatid cohesion GO:0070602 9.58 AXIN2 CTNNB1
37 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 9.57 SFRP1 SFRP2
38 regulation of midbrain dopaminergic neuron differentiation GO:1904956 9.56 SFRP1 SFRP2
39 negative regulation of Wnt signaling pathway GO:0030178 9.23 DACT1 DKK1 FRZB SFRP1 SFRP2 SFRP4
40 cell differentiation GO:0030154 10.1 CTNNB1 EGFR FRZB SFRP1 SFRP2 SFRP4
41 positive regulation of transcription, DNA-templated GO:0045893 10.06 AXIN1 CTNNB1 EGFR SFRP1 TP53
42 negative regulation of cell proliferation GO:0008285 10.06 AXIN2 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
43 negative regulation of apoptotic process GO:0043066 10.04 CTNNB1 DKK1 EGFR SFRP1 TP53
44 multicellular organism development GO:0007275 10.03 AXIN1 AXIN2 DACT1 DKK1 EGFR FRZB

Molecular functions related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.73 AXIN1 CTNNB1 EGFR TP53
2 ubiquitin protein ligase binding GO:0031625 9.71 AXIN1 AXIN2 EGFR TP53
3 enzyme binding GO:0019899 9.55 AXIN1 AXIN2 CTNNB1 EGFR TP53
4 beta-catenin binding GO:0008013 9.54 AXIN1 AXIN2 DACT1
5 protein phosphatase binding GO:0019903 9.5 CTNNB1 EGFR TP53
6 RNA polymerase II transcription factor binding GO:0001085 9.43 CTNNB1 DACT1 TP53
7 I-SMAD binding GO:0070411 9.13 AXIN1 AXIN2 CTNNB1
8 Wnt-protein binding GO:0017147 9.1 FRZB SFRP1 SFRP2 SFRP4 SFRP5 WIF1

Sources for Esophageal Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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