MCID: ESP010
MIFTS: 36

Esophageal Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Esophageal Basaloid Squamous Cell Carcinoma:

Name: Esophageal Basaloid Squamous Cell Carcinoma 12 15
Basaloid Squamous Carcinoma of Esophagus 12
Esophageal Basaloid Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7051
NCIt 50 C7032
UMLS 73 C1333443

Summaries for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards based summary : Esophageal Basaloid Squamous Cell Carcinoma, also known as basaloid squamous carcinoma of esophagus, is related to basaloid squamous cell carcinoma and squamous cell carcinoma, and has symptoms including pain and regurgitation. An important gene associated with Esophageal Basaloid Squamous Cell Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Signaling by GPCR and PI3K-Akt signaling pathway. Affiliated tissues include neutrophil, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Esophageal Basaloid Squamous Cell Carcinoma

Diseases related to Esophageal Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.3 EGFR KRT14 TP53
2 squamous cell carcinoma 30.6 CTNNB1 EGFR TP53 WWOX
3 brain ependymoma 10.8 EGFR TP53
4 mucoepidermoid esophageal carcinoma 10.8 TP53 WWOX
5 benign breast adenomyoepithelioma 10.7 EGFR KRT14
6 microglandular adenosis 10.7 EGFR TP53
7 oncocytic breast carcinoma 10.7 EGFR KRT14
8 lymph node cancer 10.6 TP53 WWOX
9 pulmonary blastoma 10.6 EGFR TP53
10 female reproductive endometrioid cancer 10.6 CTNNB1 TP53
11 pleomorphic carcinoma 10.6 EGFR TP53
12 spiradenoma 10.6 KRT14 TP53
13 hair follicle neoplasm 10.5 CTNNB1 KRT14
14 breast squamous cell carcinoma 10.5 EGFR KRT14 TP53
15 breast benign neoplasm 10.5 KRT14 TP53
16 pre-malignant neoplasm 10.5 EGFR KRT14 TP53
17 in situ carcinoma 10.4 EGFR KRT14 TP53
18 ductal carcinoma in situ 10.4 EGFR KRT14 TP53
19 gliomatosis cerebri 10.4 EGFR TP53
20 esophagitis 10.4
21 central nervous system organ benign neoplasm 10.4 CTNNB1 TP53
22 colorectal adenocarcinoma 10.4 CTNNB1 EGFR TP53
23 thoracic benign neoplasm 10.4 KRT14 TP53
24 female reproductive organ cancer 10.4 CTNNB1 EGFR TP53
25 respiratory system cancer 10.4 CTNNB1 EGFR TP53
26 uterine carcinosarcoma 10.4 CTNNB1 EGFR TP53
27 breast ductal carcinoma 10.4 CTNNB1 EGFR TP53
28 oropharynx cancer 10.4 EGFR TP53
29 squamous cell papilloma 10.3 SFRP4 TP53 WWOX
30 pancreas adenocarcinoma 10.3 CTNNB1 EGFR TP53
31 soft tissue sarcoma 10.2 EGFR TP53
32 gastrointestinal system benign neoplasm 10.2 CTNNB1 TP53 WIF1
33 adamantinoma of long bones 10.2 CTNNB1 EGFR TP53
34 cell type cancer 10.1 CTNNB1 EGFR TP53 WWOX
35 gastrointestinal system cancer 10.1 CTNNB1 EGFR TP53 WWOX
36 adult hepatocellular carcinoma 10.0 AXIN1 CTNNB1 TP53
37 embryonal sarcoma 10.0 AXIN1 CTNNB1 TP53
38 familial adenomatous polyposis 9.9 AXIN1 CTNNB1 TP53
39 brain cancer 9.7 AXIN1 CTNNB1 EGFR TP53
40 medulloblastoma 9.5 AXIN1 CTNNB1 EGFR TP53
41 cholangiocarcinoma 9.4 CTNNB1 EGFR SFRP1 TP53
42 adenoma 9.3 AXIN2 CTNNB1 TP53

Graphical network of the top 20 diseases related to Esophageal Basaloid Squamous Cell Carcinoma:



Diseases related to Esophageal Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Esophageal Basaloid Squamous Cell Carcinoma

UMLS symptoms related to Esophageal Basaloid Squamous Cell Carcinoma:


pain, regurgitation

MGI Mouse Phenotypes related to Esophageal Basaloid Squamous Cell Carcinoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 AXIN2 DACT1 CTNNB1 AXIN1 KRT14 SFRP4
2 mortality/aging MP:0010768 10.27 AXIN2 DACT1 CTNNB1 AXIN1 KRT14 SFRP4
3 cardiovascular system MP:0005385 10.22 DACT1 AXIN2 CTNNB1 AXIN1 SFRP2 EGFR
4 limbs/digits/tail MP:0005371 10.22 EGFR CTNNB1 AXIN1 AXIN2 DACT1 SFRP4
5 embryo MP:0005380 10.19 DACT1 AXIN2 CTNNB1 AXIN1 SFRP2 EGFR
6 endocrine/exocrine gland MP:0005379 10.18 AXIN2 CTNNB1 SFRP2 KRT14 EGFR SFRP1
7 craniofacial MP:0005382 10.16 AXIN2 CTNNB1 AXIN1 KRT14 EGFR SFRP1
8 nervous system MP:0003631 10.14 DACT1 AXIN2 CTNNB1 AXIN1 FRZB SFRP2
9 digestive/alimentary MP:0005381 10.09 DACT1 CTNNB1 AXIN1 KRT14 EGFR TP53
10 no phenotypic analysis MP:0003012 9.97 DACT1 AXIN2 CTNNB1 SFRP2 EGFR SFRP1
11 reproductive system MP:0005389 9.93 EGFR CTNNB1 AXIN1 AXIN2 DACT1 KRT14
12 normal MP:0002873 9.92 AXIN2 CTNNB1 AXIN1 FRZB SFRP2 EGFR
13 neoplasm MP:0002006 9.91 CTNNB1 KRT14 EGFR TP53 WIF1 WWOX
14 hearing/vestibular/ear MP:0005377 9.89 AXIN1 CTNNB1 KRT14 EGFR TP53
15 renal/urinary system MP:0005367 9.73 DACT1 AXIN1 CTNNB1 EGFR TP53 SFRP4
16 respiratory system MP:0005388 9.43 AXIN1 CTNNB1 KRT14 EGFR TP53 SFRP4
17 skeleton MP:0005390 9.36 AXIN2 DACT1 CTNNB1 AXIN1 SFRP4 EGFR

Drugs & Therapeutics for Esophageal Basaloid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Basaloid Squamous Cell Carcinoma

Genetic Tests for Esophageal Basaloid Squamous Cell Carcinoma

Anatomical Context for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Esophageal Basaloid Squamous Cell Carcinoma:

41
Neutrophil

Publications for Esophageal Basaloid Squamous Cell Carcinoma

Articles related to Esophageal Basaloid Squamous Cell Carcinoma:

# Title Authors Year
1
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
2
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
3
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
4
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
5
Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. ( 22607702 )
2012
6
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. ( 10885705 )
2000

Variations for Esophageal Basaloid Squamous Cell Carcinoma

Expression for Esophageal Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Basaloid Squamous Cell Carcinoma.

Pathways for Esophageal Basaloid Squamous Cell Carcinoma

Pathways related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
2
Show member pathways
12.82 AXIN1 AXIN2 CTNNB1 EGFR TP53
3
Show member pathways
12.72 AXIN1 AXIN2 CTNNB1 EGFR TP53
4 12.68 AXIN1 AXIN2 CTNNB1 EGFR TP53
5
Show member pathways
12.61 AXIN1 AXIN2 CTNNB1 EGFR TP53
6
Show member pathways
12.46 AXIN1 AXIN2 CTNNB1 DACT1 SFRP1 SFRP2
7
Show member pathways
12.37 AXIN1 AXIN2 CTNNB1 SFRP1
8
Show member pathways
12.35 AXIN1 AXIN2 EGFR TP53
9
Show member pathways
12.12 AXIN1 AXIN2 CTNNB1 SFRP1 SFRP2 SFRP4
10 12.03 AXIN2 CTNNB1 EGFR TP53
11 12.01 AXIN1 AXIN2 CTNNB1
12 12 CTNNB1 EGFR TP53
13 11.95 AXIN1 AXIN2 CTNNB1
14 11.92 CTNNB1 FRZB SFRP4
15 11.91 AXIN1 AXIN2 CTNNB1 SFRP1 WIF1
16 11.85 AXIN1 CTNNB1 TP53
17
Show member pathways
11.8 AXIN1 CTNNB1 FRZB TP53 WIF1
18 11.79 AXIN1 AXIN2 CTNNB1
19 11.78 AXIN1 CTNNB1 EGFR TP53
20 11.58 AXIN1 CTNNB1 EGFR
21
Show member pathways
11.5 AXIN1 AXIN2 CTNNB1 FRZB SFRP1 SFRP2
22 11.44 AXIN1 AXIN2 CTNNB1
23 11.36 AXIN1 CTNNB1 WIF1
24 11.19 CTNNB1 EGFR TP53
25 11.11 AXIN1 CTNNB1 EGFR
26 10.96 AXIN2 CTNNB1 WIF1
27
Show member pathways
10.87 SFRP1 SFRP2 WIF1
28 10.75 AXIN1 CTNNB1 SFRP4
29 10.73 CTNNB1 SFRP1

GO Terms for Esophageal Basaloid Squamous Cell Carcinoma

Cellular components related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 8.92 AXIN1 AXIN2 CTNNB1 DACT1

Biological processes related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.99 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 TP53
2 cell proliferation GO:0008283 9.96 AXIN2 CTNNB1 EGFR TP53
3 positive regulation of canonical Wnt signaling pathway GO:0090263 9.87 AXIN1 AXIN2 DACT1 EGFR SFRP1 SFRP2
4 positive regulation of protein phosphorylation GO:0001934 9.85 AXIN1 AXIN2 EGFR
5 negative regulation of cell growth GO:0030308 9.84 FRZB SFRP1 SFRP2 TP53
6 regulation of Wnt signaling pathway GO:0030111 9.83 AXIN1 AXIN2 DACT1 SFRP2 SFRP5
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.8 AXIN1 EGFR SFRP2
8 positive regulation of cell growth GO:0030307 9.8 EGFR SFRP1 SFRP2
9 positive regulation of fat cell differentiation GO:0045600 9.8 FRZB SFRP1 SFRP2 WIF1
10 non-canonical Wnt signaling pathway GO:0035567 9.8 FRZB SFRP1 SFRP2 SFRP4 SFRP5
11 canonical Wnt signaling pathway GO:0060070 9.8 AXIN1 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
12 cellular response to growth factor stimulus GO:0071363 9.79 CTNNB1 EGFR SFRP1
13 somitogenesis GO:0001756 9.78 AXIN2 SFRP1 SFRP2
14 negative regulation of canonical Wnt signaling pathway GO:0090090 9.76 AXIN1 AXIN2 DACT1 FRZB SFRP1 SFRP2
15 neural tube development GO:0021915 9.75 DACT1 SFRP1 SFRP2
16 digestive tract morphogenesis GO:0048546 9.7 EGFR SFRP1 SFRP2
17 Wnt signaling pathway GO:0016055 9.7 AXIN1 AXIN2 CTNNB1 DACT1 FRZB SFRP1
18 negative regulation of epithelial to mesenchymal transition GO:0010719 9.68 SFRP1 SFRP2
19 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.67 SFRP1 WWOX
20 negative regulation of osteoclast differentiation GO:0045671 9.67 CTNNB1 SFRP1
21 beta-catenin destruction complex disassembly GO:1904886 9.67 AXIN1 CTNNB1
22 negative regulation of JUN kinase activity GO:0043508 9.66 SFRP1 SFRP2
23 planar cell polarity pathway involved in neural tube closure GO:0090179 9.65 SFRP1 SFRP2
24 negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 9.65 SFRP1 SFRP2
25 cellular response to X-ray GO:0071481 9.64 SFRP1 SFRP2
26 regulation of BMP signaling pathway GO:0030510 9.63 SFRP4 SFRP5
27 dorsal/ventral axis specification GO:0009950 9.62 CTNNB1 SFRP1
28 regulation of establishment of planar polarity GO:0090175 9.6 SFRP1 SFRP2
29 development of primary male sexual characteristics GO:0046546 9.59 SFRP1 SFRP2
30 Wnt signaling pathway involved in somitogenesis GO:0090244 9.58 SFRP1 SFRP2
31 regulation of centromeric sister chromatid cohesion GO:0070602 9.57 AXIN2 CTNNB1
32 regulation of midbrain dopaminergic neuron differentiation GO:1904956 9.56 SFRP1 SFRP2
33 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 9.55 SFRP1 SFRP2
34 negative regulation of Wnt signaling pathway GO:0030178 9.28 AXIN1 DACT1 FRZB SFRP1 SFRP2 SFRP4
35 multicellular organism development GO:0007275 10.11 AXIN1 AXIN2 DACT1 EGFR FRZB SFRP1
36 cell differentiation GO:0030154 10.08 CTNNB1 EGFR FRZB SFRP1 SFRP2 SFRP4
37 negative regulation of cell proliferation GO:0008285 10.06 AXIN2 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
38 apoptotic process GO:0006915 10.05 AXIN1 SFRP2 SFRP5 TP53 WWOX
39 positive regulation of transcription, DNA-templated GO:0045893 10.04 AXIN1 CTNNB1 EGFR SFRP1 TP53

Molecular functions related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.88 FRZB SFRP1 SFRP2 SFRP4 SFRP5
2 protein kinase binding GO:0019901 9.8 AXIN1 CTNNB1 EGFR TP53
3 ubiquitin protein ligase binding GO:0031625 9.76 AXIN1 AXIN2 EGFR TP53
4 enzyme binding GO:0019899 9.63 AXIN1 AXIN2 CTNNB1 EGFR TP53 WWOX
5 beta-catenin binding GO:0008013 9.61 AXIN1 AXIN2 DACT1
6 protein phosphatase binding GO:0019903 9.58 CTNNB1 EGFR TP53
7 RNA polymerase II transcription factor binding GO:0001085 9.54 CTNNB1 DACT1 TP53
8 I-SMAD binding GO:0070411 9.43 AXIN1 AXIN2 CTNNB1
9 Wnt-activated receptor activity GO:0042813 9.35 FRZB SFRP1 SFRP2 SFRP4 SFRP5
10 Wnt-protein binding GO:0017147 9.1 FRZB SFRP1 SFRP2 SFRP4 SFRP5 WIF1
11 protein binding GO:0005515 10.17 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB

Sources for Esophageal Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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