MCID: ESP018
MIFTS: 47

Esophageal Candidiasis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases
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Aliases & Classifications for Esophageal Candidiasis

MalaCards integrated aliases for Esophageal Candidiasis:

Name: Esophageal Candidiasis 11 2 14 75
Candidiasis of the Esophagus 11 71
Esophageal Moniliasis 11
Candidal Esophagitis 11
Candida Esophagitis 11
Esophageal Thrush 11

Classifications:



External Ids:

Disease Ontology 11 DOID:13146
ICD9CM 34 112.84
NCIt 49 C27027
SNOMED-CT 68 20639004
UMLS 71 C0239295

Summaries for Esophageal Candidiasis

CDC: 2 Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candida normally lives inside the body (in places such as the mouth, throat, gut, and vagina) and on skin without causing any problems.1 Sometimes, Candida can multiply and cause an infection if the environment inside the mouth, throat, or esophagus changes in a way that encourages fungal growth. Candidiasis in the mouth and throat is also called "thrush" or oropharyngeal candidiasis. Candidiasis in the esophagus (the tube that connects the throat to the stomach) is called esophageal candidiasis or Candida esophagitis. Esophageal candidiasis is one of the most common infections in people living with HIV/AIDS

MalaCards based summary: Esophageal Candidiasis, also known as candidiasis of the esophagus, is related to oral candidiasis and laryngitis. An important gene associated with Esophageal Candidiasis is CD4 (CD4 Molecule), and among its related pathways/superpathways are PAK Pathway and T-cell activation SARS-CoV-2. The drugs Caspofungin and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and colon, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology: 11 A candidiasis that involves fungal infection of the esophagus by Candida albicans in immunocompromised people, resulting in lesions, bleeding, painful swallowing and substernal pain.

Wikipedia: 75 Esophageal candidiasis is an opportunistic infection of the esophagus by Candida albicans. The disease... more...

Related Diseases for Esophageal Candidiasis

Diseases related to Esophageal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 646)
# Related Disease Score Top Affiliating Genes
1 oral candidiasis 30.8 IL17A CLEC7A CD8A CD4 CCR6 CARD9
2 laryngitis 30.5 CD4 ATP4A ATP12A
3 viral esophagitis 30.4 ATP4A ATP12A
4 alcohol use disorder 30.4 CD4 CCR6 ATP12A
5 fungal esophagitis 30.3 ATP4A ATP12A
6 candidiasis 30.3 IL5 IL17A CYP51A1 CLEC7A CARD9 AIRE
7 esophagitis 30.3 IL5 IL13 CYP2C19 CCL26 CAPN14
8 hernia, hiatus 30.2 CYP2C19 ATP4A ATP12A
9 nutritional deficiency disease 30.2 CCR6 ATP4A ATP12A
10 pharyngitis 30.2 CD8A CD4 CCR6
11 peptic esophagitis 30.0 CYP2C19 CCR6 CCL26 ATP4A ATP12A
12 inflammatory bowel disease 1 29.9 IL17A CCR6 CARD9
13 gastritis 29.9 IL17A CYP2C19 CCR6 ATP4A
14 aphthous stomatitis 29.8 IL17A CD8A CD4 CCR6
15 pernicious anemia 29.8 CD4 CCR6 ATP4A ATP12A AIRE
16 aspergillosis 29.8 IL5 CLEC7A CCR6
17 peptic ulcer disease 29.8 CYP3A4 CYP2C19 CCR6 ATP4A ATP12A
18 syphilis 29.8 IL17A CD8A CD4 CCR6
19 spondyloarthropathy 1 29.7 IL17A CD8A CD4 CCR6
20 deficiency anemia 29.7 CD8A CD4 CCR6 ATP4A ATP12A
21 eosinophilic gastroenteritis 29.7 IL5 IL13 CCL26 ATP4A ATP12A
22 systemic scleroderma 29.6 IL17A IL13 CD8A CD4 CCR6
23 giardiasis 29.6 IL17A CD8A CD4 ATP4A ATP12A
24 immune deficiency disease 29.6 IL17A IL13 CYP3A4 CD8A CD4 CCR6
25 viral infectious disease 29.5 IL17A IL13 CD4 CCR6
26 meningitis 29.5 IL5 IL17A IL13
27 dyskinesia of esophagus 29.5 IL13 CCL26 CAPN14 ATP4A ATP12A
28 bilirubin metabolic disorder 29.4 CYP3A4 CYP2C19 CD8A CD4 ATP4A ATP12A
29 dermatitis 29.4 IL5 IL17A IL13 CCR6
30 ulcerative colitis 29.3 IL5 IL17A IL13 CCR6
31 esophagitis, eosinophilic, 1 29.2 IL5 IL13 CCR6 CCL26 CAPN14 ATP4A
32 colitis 29.2 IL5 IL17A IL13 CD4 CCR6
33 rhinitis 29.1 IL5 IL17A IL13 CYP3A4
34 intrinsic asthma 29.1 IL5 IL17A IL13 CD4 CCR6
35 gastroesophageal reflux 29.1 IL5 CYP3A4 CYP2C19 CCL26 ATP4A ATP12A
36 asthma 29.0 IL5 IL17A IL13 CYP3A4 CD4 CCR6
37 cryptococcal meningitis 28.9 IL17A CYP51A1 CLEC7A CD8A CD4 CCR6
38 pneumocystosis 28.9 IL17A CLEC7A CD8A CD4 CCR6 CARD9
39 respiratory failure 28.9 IL5 IL17A IL13 CD8A CD4 CCR6
40 chronic mucocutaneous candidiasis 28.8 IL17A CLEC7A CD8A CD4 CCR6 CARD9
41 allergic disease 28.8 IL5 IL17A IL13 CYP3A4 CD8A CD4
42 common cold 28.7 IL5 IL17A IL13 CD8A CD4 CCR6
43 dermatitis, atopic 28.7 IL5 IL17A IL13 CD8A CD4 CCR6
44 invasive aspergillosis 28.2 IL17A CYP51A1 CYP3A4 CYP2C19 CLEC7A CD4
45 skin disease 28.0 IL5 IL17A IL13 CYP3A4 CD8A CD4
46 fungal infectious disease 27.7 IL5 IL17A IL13 CYP51A1 CLEC7A CD8A
47 opportunistic mycosis 27.2 IL5 IL17A IL13 CYP51A1 CLEC7A CD8A
48 acquired immunodeficiency syndrome 10.6
49 human immunodeficiency virus type 1 10.4
50 pancreatic vasoactive intestinal peptide producing tumor 10.4 ATP4A ATP12A

Comorbidity relations with Esophageal Candidiasis via Phenotypic Disease Network (PDN): (show all 17)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Chronic Kidney Disease Decubitus Ulcer
Deficiency Anemia Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Heart Disease Iron Deficiency Anemia
Neutropenia Oral Candidiasis
Protein-Energy Malnutrition Respiratory Failure
Swallowing Disorders

Graphical network of the top 20 diseases related to Esophageal Candidiasis:



Diseases related to Esophageal Candidiasis

Symptoms & Phenotypes for Esophageal Candidiasis

GenomeRNAi Phenotypes related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ATP4A CCR6 CLEC7A CYP51A1 IL17A IL5

MGI Mouse Phenotypes related to Esophageal Candidiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 AIRE ATP12A ATP4A CARD9 CCL26 CCR6
2 digestive/alimentary MP:0005381 9.81 AIRE ATP12A ATP4A CD4 CLEC7A CYP51A1
3 immune system MP:0005387 9.7 AIRE ATP4A CARD9 CCR6 CD4 CD8A
4 hematopoietic system MP:0005397 9.36 AIRE ATP4A CARD9 CCL26 CCR6 CD4

Drugs & Therapeutics for Esophageal Candidiasis

Drugs for Esophageal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718
2
Micafungin Approved, Investigational Phase 3 235114-32-6 477468
3
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Voriconazole Approved Phase 3 137234-62-9 71616
7 Anti-Infective Agents Phase 3
8 Antifungal Agents Phase 3
9 Hormones Phase 3
10 Hormone Antagonists Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 3
12 Cytochrome P-450 CYP3A Inhibitors Phase 3
13 Echinocandins Phase 1
14
Ketoconazole Approved, Investigational 65277-42-1, 142128-57-2 47576 3823 638701
15
Itraconazole Approved, Investigational 84625-61-6 55283
16
Amphotericin B Approved, Investigational 1397-89-3 5280965
17 Pharmaceutical Solutions
18
Hydroxyitraconazole 108222
19 Amebicides
20 Anti-Bacterial Agents
21 Antiprotozoal Agents
22 Antiparasitic Agents
23 Liposomal amphotericin B

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Comparative Trial of Two Dosing Regimens of Micafungin (FK463) Versus Caspofungin for the Treatment of Esophageal Candidiasis Completed NCT00665639 Phase 3 micafungin;caspofungin
2 A Phase 3, Randomized, Double-Blind, Comparative Trial of Micafungin Versus Fluconazole for the Treatment of Esophageal Candidiasis Completed NCT00666185 Phase 3 Micafungin;Fluconazole
3 A Non-comparative, Multicenter, Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Acetate (MK-0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults Completed NCT00635648 Phase 3 caspofungin acetate
4 An Open Multicenter Trial of Fluconazole Oral Suspension in the Treatment of Esophageal Candidiasis in Immunocompromised Patients Completed NCT00002339 Phase 3 Fluconazole
5 A Prospective, Open-label, Non-comparative Study To Assess The Safety, Tolerability And Efficacy Of Voriconazole For The Primary And Salvage Treatment Of Invasive Candidiasis, Candidemia, And Esophageal Candidiasis In Pediatric Subjects Terminated NCT01092832 Phase 3 voriconazole
6 A Phase 1, Open-Label Study Of The Safety And Pharmacokinetics Of Repeated-Dose Micafungin (FK463) In Children (2-5 Years AND 6-11 Years) And Adolescents (12-16 Years) With Esophageal Candidiasis Or Other Invasive Candidiasis Completed NCT00608335 Phase 1 Micafungin
7 A Phase 1, Open-Label Study Of The Safety And Pharmacokinetics Of Repeated-Dose Micafungin (FK463) In Infants And Toddlers (≥4 Months TO < 24 Months Of Age) With Esophageal Candidiasis Or Other Invasive Candidiasis Completed NCT00607763 Phase 1 Micafungin (Mycamine)
8 A Randomized Comparative Multicenter Trial of Fluconazole and Ketoconazole in the Treatment of Esophageal Candidiasis in Immunocompromised Patients Completed NCT00002304 Ketoconazole;Fluconazole
9 Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis. Completed NCT00002132 Itraconazole;Fluconazole
10 Evaluation of Amphotericin B in the Treatment of Biopsy Proven Candida Esophagitis in Immunocompromised Patients Completed NCT00002041 Amphotericin B
11 An Open, Serial-Panel, Multiple-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of L-743,872 in Patients With Candida Esophagitis Completed NCT00005921 L-743,872

Search NIH Clinical Center for Esophageal Candidiasis

Genetic Tests for Esophageal Candidiasis

Anatomical Context for Esophageal Candidiasis

Organs/tissues related to Esophageal Candidiasis:

MalaCards : Skin, Bone Marrow, Colon, Liver, Kidney, Bone, Lung

Publications for Esophageal Candidiasis

Articles related to Esophageal Candidiasis:

(show top 50) (show all 896)
# Title Authors PMID Year
1
Fungal esophagitis associated with tuberculous pericarditis in an human immunodeficiency virus-positive patient: a case report. 62
36345027 2022
2
Broncho-esophageal fistula as a complication of transmural candida esophagitis in a patient with malnutrition. 62
34453968 2022
3
Prevalence and risk factors for Candida esophagitis among human immunodeficiency virus-negative individuals. 62
36338217 2022
4
Esophageal Intramural Pseudodiverticulosis Diagnosed by Combining Esophagogastroduodenoscopy, Esophagography, and High-resolution manometry: A Case Report. 62
36223924 2022
5
Case report: Tumor collision in the colon, adenocarcinoma - lymphoma. 62
36380539 2022
6
Late-onset opportunistic infections while receiving anti-retroviral therapy in Latin America: burden and risk factors. 62
35768025 2022
7
The estimated burden of fungal diseases in Mali. 62
36270216 2022
8
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and esophageal rupture by candida infection: A case report and review. 62
35597148 2022
9
Verrucous carcinoma of the esophagus with complete response after chemoradiotherapy. 62
35781764 2022
10
Nausea and vomiting caused by candida esophagitis in an elderly frail patient. 62
35822125 2022
11
Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis. 62
35699443 2022
12
Double acute esophageal candidiasis and cytomegalovirus (CMV) infection in a young healthy patient: a call to think about HIV infection in AIDS. 62
35170324 2022
13
Recidivant odynophagia secondary to persistent esophageal candidiasis in an immunocompetent patient: the importance of brush cytology. 62
35078324 2022
14
Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis: A case report. 62
35979125 2022
15
[Acute Diseases of the Esophagus - Esophagitis]. 62
35440200 2022
16
Esophageal Candidiasis in a Non-HIV Patient: A Primary Care Diagnosis. 62
35602778 2022
17
A case of esophageal candidiasis in a psoriatic patient treated with ixekizumab: Should treatment be discontinued? 62
35137503 2022
18
Deep learning-based detection of eosinophilic esophagitis. 62
34058769 2022
19
Risk of candidiasis associated with interleukin-17 inhibitors: A real-world observational study of multiple independent sources. 62
34950923 2022
20
CARD9 Expression Pattern, Gene Dosage, and Immunodeficiency Phenotype Revisited. 62
34791587 2022
21
Case Report: Eosinophilic Esophagitis in a Patient With a Novel STAT1 Gain-of-Function Pathogenic Variant. 62
35126392 2022
22
Simultaneous Massive Esophageal Mucosal Candidiasis and Profound Cytomegaloviral Esophageal Ulcers with Recurrence of Both Infections 12 Years Later in a Patient with Long-Standing AIDS: Endoscopic, Radiologic, and Pathologic Findings. 62
35265384 2022
23
Association of Candida esophagitis with acute esophageal necrosis. 62
36304599 2022
24
Prevalence, Predictors, and Outcomes of Esophageal Candidiasis in Cirrhosis: An Observational Study With Systematic Review and Meta-Analysis (CANDID-VIEW). 62
35068792 2022
25
Abrupt Development of Esophageal Candidiasis after Secukinumab Treatment in a Psoriatic Patient. 62
34858013 2021
26
Effectiveness and Safety of High- vs Low-Dose Swallowed Topical Steroids for Maintenance Treatment of Eosinophilic Esophagitis: A Multicenter Observational Study. 62
32798703 2021
27
Multisystem Autoimmune Inflammatory Disease, Including Colitis, Due to Inborn Error of Immunity. 62
34686572 2021
28
Effect of Dysphagia on Hospital Outcomes and Readmissions in Patients with Human Immunodeficiency Virus. 62
34729612 2021
29
Efficacy and acceptability of different anti-fungal interventions in oropharyngeal or esophageal candidiasis in HIV co-infected adults: a pilot network meta-analysis. 62
33899657 2021
30
Risk factors for the development of esophageal candidiasis among patients in community hospital. 62
34667198 2021
31
A 30-Year-Old Immune Deficient Woman With Persistent Cough and Shortness of Breath. 62
34625181 2021
32
Initial diagnosis of HIV/AIDS in patients presenting to the emergency department: Imaging and clinical findings at a single institution. 62
34020125 2021
33
Immunologic biomarkers, morbidity and mortality among HIV patients hospitalised in a Tertiary Care Hospital in the Brazilian Amazon. 62
34445956 2021
34
Dysphagia, reflux and related sequelae due to altered physiology in scleroderma. 62
34497445 2021
35
Association of Eosinophilic Esophagitis and Human Immunodeficiency Virus. 62
32851497 2021
36
Laparoscopic Sleeve Gastrectomy Esophageal Candidiasis an Exceptional Complication of Laparoscopic Sleeve Gastrectomy: First Case Report. 62
33866533 2021
37
Genotyping, antifungal susceptibility, enzymatic activity, and phenotypic variation in Candida albicans from esophageal candidiasis. 62
33988259 2021
38
Oropharyngeal candidiasis outcomes in renal transplant recipients receiving nystatin versus no antifungal prophylaxis. 62
33387388 2021
39
Development of Epidermoid Metaplasia of the Mucosa in Association with Esophageal Intramural Pseudodiverticulosis and Candidiasis. 62
34594170 2021
40
Candida esophagitis incidentally detected by 18F-FDG PET/CT in a patient with CNS lymphoma. 62
34084527 2021
41
Mortality in Perinatally HIV-infected Adolescents After Transition to Adult Care in Spain. 62
33264211 2021
42
Candida Esophagitis Associated With Adalimumab for Hidradenitis Suppurativa. 62
33956612 2021
43
Clinical Characteristics and Manifestations of Fungal Esophagitis: A Single-Center Experience in South China. 62
33531895 2021
44
The burden of serious fungal infections in Sierra Leone: a national estimate. 62
34262759 2021
45
Formulation, in vitro characterization and optimization of taste-masked orally disintegrating co-trimoxazole tablet by direct compression. 62
33725014 2021
46
Upper gastrointestinal endoscopy; A study from a rural population of Sindh, Pakistan. 62
33437243 2021
47
Verrucous esophageal carcinoma is a unique indolent subtype of squamous cell carcinoma: a systematic review and individual patient regression analysis. 62
33079233 2021
48
Auto-brewery syndrome caused by oral fungi and periodontal disease bacteria. 62
33976897 2021
49
Efficacy and safety of peroral endoscopic myotomy after prior sleeve gastrectomy and gastric bypass surgery. 62
33362906 2020
50
Verrucous carcinoma of the esophagus - a case report and literature review. 62
33036050 2020

Variations for Esophageal Candidiasis

Expression for Esophageal Candidiasis

Search GEO for disease gene expression data for Esophageal Candidiasis.

Pathways for Esophageal Candidiasis

GO Terms for Esophageal Candidiasis

Biological processes related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.85 CLEC7A CD8A CD4
2 heterocycle metabolic process GO:0046483 9.71 CYP3A4 CYP2C19
3 positive regulation of interleukin-23 production GO:0032747 9.62 IL17A CLEC7A
4 monoterpenoid metabolic process GO:0016098 9.56 CYP3A4 CYP2C19
5 immune response GO:0006955 9.5 IL5 IL17A IL13 CD8A CD4 CCR6
6 regulation of proton transport GO:0010155 9.46 ATP4A IL13
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 IL17A CLEC7A CARD9

Molecular functions related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.56 ATP4A ATP12A
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP51A1 CYP3A4 CYP2C19
3 P-type potassium transmembrane transporter activity GO:0008556 8.96 ATP4A ATP12A
4 P-type potassium:proton transporter activity GO:0008900 8.92 ATP4A ATP12A

Sources for Esophageal Candidiasis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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