Esophageal Candidiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ESP018 MIFTS: 45	Esophageal Candidiasis Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Esophageal Candidiasis

MalaCards integrated aliases for Esophageal Candidiasis:

Name: Esophageal Candidiasis ¹² ³ ¹⁵

Candidiasis of the Esophagus ¹² ⁷³

Esophageal Moniliasis ¹²

Candidal Esophagitis ¹²

Candida Esophagitis ¹²

Esophageal Thrush ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13146

ICD10 ³³ B37.81

ICD9CM ³⁵ 112.84

NCIt ⁵⁰ C27027

SNOMED-CT ⁶⁸ 20639004

UMLS ⁷³ C0239295

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Summaries for Esophageal Candidiasis

CDC : ³ Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candida normally lives in the digestive tract and on skin without causing any problems.1 Sometimes, Candida can multiply and cause an infection if the environment inside the mouth, throat, or esophagus changes in a way that encourages fungal growth.

MalaCards based summary : Esophageal Candidiasis, also known as candidiasis of the esophagus, is related to laryngitis and esophagitis, eosinophilic, 1. An important gene associated with Esophageal Candidiasis is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Linoleic acid metabolism. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver.

Disease Ontology : ¹² A candidiasis that involves fungal infection of the esophagus by Candida albicans in immunocompromised people, resulting in lesions, bleeding, painful swallowing and substernal pain.

Wikipedia : ⁷⁶ Esophageal candidiasis is an opportunistic infection of the esophagus by Candida albicans. The disease... more...

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Related Diseases for Esophageal Candidiasis

Diseases related to Esophageal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score	Top Affiliating Genes
1	laryngitis	30.2	ATP12A ATP4A
2	esophagitis, eosinophilic, 1	30.1	ATP12A ATP4A
3	esophageal varix	30.0	ATP12A ATP4A
4	peptic esophagitis	29.7	ATP12A ATP4A CYP2C19
5	candidiasis	10.9
6	human immunodeficiency virus infectious disease	10.2
7	acquired immunodeficiency syndrome	10.2
8	fungal esophagitis	10.2	ATP12A ATP4A
9	diclofenac allergy	10.2	ATP12A ATP4A
10	gastroduodenal crohn's disease	10.2	ATP12A ATP4A
11	neonatal candidiasis	10.2	ATP12A ATP4A
12	photoallergic dermatitis	10.2	ATP12A ATP4A
13	squamous papillomatosis	10.2	ATP12A ATP4A
14	toxic megacolon	10.2	ATP12A ATP4A
15	aspiration pneumonitis	10.2	ATP12A ATP4A
16	gastrointestinal neuroendocrine benign tumor	10.2	ATP12A ATP4A
17	gastric antral vascular ectasia	10.2	ATP12A ATP4A
18	granulomatous gastritis	10.2	ATP12A ATP4A
19	gastric neuroendocrine neoplasm	10.2	ATP12A ATP4A
20	acute laryngitis	10.2	ATP12A ATP4A
21	duodenitis	10.2	ATP12A ATP4A
22	rumination disorder	10.2	ATP12A ATP4A
23	active peptic ulcer disease	10.2	ATP12A ATP4A
24	congenital disorder of deglycosylation	10.2	ATP12A ATP4A
25	bladder calculus	10.2	ATP12A ATP4A
26	ischemic neuropathy	10.2	ATP12A ATP4A
27	bile reflux	10.2	ATP12A ATP4A
28	capillary disease	10.2	ATP12A ATP4A
29	dyskinesia of esophagus	10.2	ATP12A ATP4A
30	anismus	10.2	ATP12A ATP4A
31	postsurgical hypothyroidism	10.2	ATP12A ATP4A
32	lymphocytic colitis	10.2	ATP12A ATP4A
33	esophageal atresia/tracheoesophageal fistula	10.2	ATP12A ATP4A
34	clostridium difficile colitis	10.2	ATP12A ATP4A
35	diarrhea 1, secretory chloride, congenital	10.2	ATP12A ATP4A
36	microscopic colitis	10.2	ATP12A ATP4A
37	laryngeal tuberculosis	10.1	ATP12A ATP4A
38	eosinophilic gastritis	10.1	ATP12A ATP4A
39	esophagus adenocarcinoma	10.1	ATP12A ATP4A
40	chronic intestinal vascular insufficiency	10.1	ATP12A ATP4A
41	esophagitis	10.1
42	polyposis, skin pigmentation, alopecia, and fingernail changes	10.1	ATP12A ATP4A
43	jejunoileitis	10.1	ATP12A ATP4A
44	pancreatic steatorrhea	10.1	ATP12A ATP4A
45	superior mesenteric artery syndrome	10.1	ATP12A ATP4A
46	duodenal disease	10.1	ATP12A ATP4A
47	gastric lymphoma	10.1	ATP12A ATP4A
48	lower urinary tract calculus	10.1	ATP12A ATP4A
49	myopathy, x-linked, with excessive autophagy	10.1	ATP12A ATP4A
50	aspiration pneumonia	10.1	ATP12A ATP4A

Comorbidity relations with Esophageal Candidiasis via Phenotypic Disease Network (PDN): (show all 18)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Bronchitis
Chronic Kidney Failure	Decubitus Ulcer
Deficiency Anemia	Esophageal Disease
Esophagitis	Familial Atrial Fibrillation
Heart Disease	Iron Deficiency Anemia
Ischemic Heart Disease	Neutropenia
Oral Candidiasis	Protein-Energy Malnutrition
Respiratory Failure	Swallowing Disorders

Graphical network of the top 20 diseases related to Esophageal Candidiasis:

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Symptoms & Phenotypes for Esophageal Candidiasis

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Drugs & Therapeutics for Esophageal Candidiasis

Drugs for Esophageal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Caspofungin

Approved

Phase 3,Phase 2,Not Applicable

179463-17-3, 162808-62-0

468682 2826718

Miconazole

Approved, Investigational, Vet_approved

Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 3,Not Applicable

86386-73-4

3365

Micafungin

Approved, Investigational

Phase 3,Phase 1

235114-32-6

3081921 477468

Clotrimazole

Approved, Vet_approved

Phase 3

23593-75-1

2812

Itraconazole

Approved, Investigational

Phase 3,Not Applicable

84625-61-6

55283

Voriconazole

Approved, Investigational

Phase 3

137234-62-9

71616

Antifungal Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Echinocandins

Phase 3,Phase 2,Phase 1

Anti-Infective Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 3,Not Applicable

Steroid Synthesis Inhibitors

Phase 3,Not Applicable

Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Hormones

Phase 3,Phase 2,Not Applicable

Cytochrome P-450 CYP2C9 Inhibitors

Phase 3,Not Applicable

Cytochrome P-450 CYP2C19 Inhibitors

Phase 3,Not Applicable

Cytochrome P-450 CYP3A Inhibitors

Phase 3,Not Applicable

Pharmaceutical Solutions

Phase 3,Not Applicable

Hydroxyitraconazole

Phase 3,Not Applicable

Acyclovir

Approved

Phase 2

59277-89-3

2022

Anidulafungin

Approved, Investigational

Phase 2

166663-25-8

166548

Midazolam

Approved, Illicit

Phase 2

59467-70-8

4192

Budesonide

Approved

Phase 2

51333-22-3

63006 5281004

Fluticasone

Approved, Experimental

Phase 2

90566-53-3

62924

Antiviral Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Anti-Bacterial Agents

Phase 2,Not Applicable

Autonomic Agents

Phase 2

Respiratory System Agents

Phase 2

Anti-Inflammatory Agents

Phase 2

glucocorticoids

Phase 2

Anti-Asthmatic Agents

Phase 2

Bronchodilator Agents

Phase 2

Peripheral Nervous System Agents

Phase 2

Anti-Allergic Agents

Phase 2

Dermatologic Agents

Phase 2

Amphotericin B

Approved, Investigational

Not Applicable

1397-89-3

5280965 14956

Ketoconazole

Approved, Investigational

Not Applicable

65277-42-1

3823 47576

Liposomal amphotericin B

Not Applicable

Antiparasitic Agents

Not Applicable

Antiprotozoal Agents

Not Applicable

Interventional clinical trials:

(show all 25)

#	Name	Status	NCT ID	Phase	Drugs
1	A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066)	Completed	NCT00635648	Phase 3	caspofungin acetate
2	Comparative Trial of Micafungin Versus Fluconazole for Treating Esophageal Candidiasis	Completed	NCT00666185	Phase 3	Micafungin;Fluconazole
3	Trial of Two Dosing Regimens of Micafungin Versus Caspofungin for the Treatment of Esophageal Candidiasis	Completed	NCT00665639	Phase 3	micafungin;caspofungin
4	A Study of Fluconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems	Completed	NCT00002339	Phase 3	Fluconazole
5	Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)	Completed	NCT00000676	Phase 3	Clotrimazole;Fluconazole
6	A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED)	Completed	NCT00717860	Phase 3	caspofungin acetate;Comparator: Micafungin sodium
7	A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection	Completed	NCT00784368	Phase 3	ITCZ Oral Solution;ITCZ-IV
8	A Study Of The Safety, Tolerability And Effective Of Voriconazole For The Treatment Of Serious Candida Infection And Candida Infection Of The Throat In Pediatric Patients	Terminated	NCT01092832	Phase 3	voriconazole
9	Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda	Completed	NCT00405821	Phase 2	Acyclovir;Placebo
10	The Safety and Efficacy of Intravenous Anidulafungin as a Treatment for Azole-Refractory Mucosal Candidiasis (FRMC)	Completed	NCT00041704	Phase 2	Anidulafungin, VER002
11	A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074)	Completed	NCT01165320	Phase 2	Caspofungin
12	Dose-Ranging Study of Oral Viscous Budesonide in Pediatrics With Eosinophilic Esophagitis	Completed	NCT00762073	Phase 2	budesonide;placebo
13	Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)	Active, not recruiting	NCT03191864	Phase 2	APT-1011;Placebo
14	Study of Mycamine® in Infants and Toddlers With Fungal Infections to Evaluate Safety and Blood Levels of the Drug	Completed	NCT00607763	Phase 1	Micafungin (Mycamine)
15	Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drug	Completed	NCT00608335	Phase 1	Micafungin
16	Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.	Completed	NCT00002132	Not Applicable	Itraconazole;Fluconazole
17	Evaluation of Amphotericin B in the Treatment of Biopsy Proven Candida Esophagitis in Immunocompromised Patients	Completed	NCT00002041	Not Applicable	Amphotericin B
18	A Study of the Side Effects of L-743,872 in Men With Candidal Esophagitis	Completed	NCT00005921	Not Applicable	L-743,872
19	A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems	Completed	NCT00002304	Not Applicable	Ketoconazole;Fluconazole
20	A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women	Completed	NCT00000744	Not Applicable	Fluconazole
21	A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients	Completed	NCT00002438	Not Applicable	Itraconazole
22	HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University	Completed	NCT01339416
23	Non-interventional Study for Prevention and Treatment of Fungal Infections in Paediatric Patients in Asia/Oceania - ERADICATE Study	Completed	NCT03174457		Micafungin
24	Kaiser Permanente HIV Cohort Study	Completed	NCT01339403
25	A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection	Withdrawn	NCT01692470		No intervention

Search NIH Clinical Center for Esophageal Candidiasis

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Genetic Tests for Esophageal Candidiasis

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Anatomical Context for Esophageal Candidiasis

MalaCards organs/tissues related to Esophageal Candidiasis:

⁴¹

Skin, Kidney, Liver, Colon, Testes, Myeloid, Lung

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Publications for Esophageal Candidiasis

Articles related to Esophageal Candidiasis:

(show top 50) (show all 123)

#	Title	Authors	Year
1	Course of Esophageal Candidiasis and Outcomes of Patients at a Single Center. ( 29702297 )	Hoversten P....Katzka D.A.	2018
2	Cytology Preparations of Formalin Fixative Aid Detection of Giardia in Duodenal Biopsy Samples: A Helpful Tool for Diagnosing Esophageal Candidiasis as Well? ( 29762142 )	SchrAPder S....GA1nther T.	2018
3	Predictors of esophageal candidiasis among patients attending endoscopy unit in a tertiary hospital, Tanzania: a retrospective cross-sectional study. ( 29977259 )	Mushi M.F....Mshana S.E.	2018
4	Challenges to &quot;Classic&quot; Esophageal Candidiasis: Looks Are Usually Deceiving. ( 28158394 )	Alsomali M.I....Arnold C.A.	2017
5	Narrow-band imaging can increase the visibility of fibrin caps after bleeding of esophageal varices: a case with extensive esophageal candidiasis. ( 28500570 )	Furuichi Y....Itoi T.	2017
6	Recurrent episodes of esophageal candidiasis without dysphagia post-Guillain-BarrAc syndrome: an unusual presentation of achalasia. ( 29038193 )	Runggaldier D....Pohl D.	2017
7	Safety, Efficacy, and Exposure-Response of Voriconazole in Pediatric Patients With Invasive Aspergillosis, Invasive Candidiasis or Esophageal Candidiasis. ( 27636722 )	Martin JM...Aram JA	2017
8	Esophageal candidiasis in HIV positive and HIV negative patients in a general hospital. ( 27728363 )	Shubham D....j P.	2016
9	Epigastric Distress Caused by Esophageal Candidiasis in 2 Patients Who Received Sorafenib Plus Radiotherapy for Hepatocellular Carcinoma: Case Report. ( 26986168 )		2016
10	Invasive Esophageal Candidiasis with Chronic Mediastinal Abscess and Fatal Pneumomediastinum. ( 27389822 )		2016
11	Antifungal Treatment is Not Required for Immunocompetent Individuals With Asymptomatic Esophageal Candidiasis. ( 26559270 )	Min Y.W....Rhee P.L.	2015
12	A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis. ( 25561337 )	Viljoen J....Ghannoum M.	2015
13	A patient with chronic diarrhea, recurrent infections, and oropharyngeal and esophageal candidiasis. ( 25478924 )	Coppens G....Baert F.	2015
14	Esophageal Candidiasis as the Initial Manifestation of Acute Myeloid Leukemia. ( 26631899 )		2015
15	Long-Term Trends in Esophageal Candidiasis Prevalence and Associated Risk Factors with or without HIV Infection: Lessons from an Endoscopic Study of 80,219 Patients. ( 26208220 )		2015
16	The clinical course of asymptomatic esophageal candidiasis incidentally diagnosed in general health inspection. ( 26083902 )		2015
17	Is empiric therapy with fluconazole appropriate for esophageal candidiasis? ( 24424852 )	Sajith K.G....Chacko A.	2014
18	Aphagia due to esophageal candidiasis in an immunocompetent patient. ( 25194226 )		2014
19	Clinical pharmacodynamic index identification for micafungin in esophageal candidiasis: dosing strategy optimization. ( 23959319 )	Andes D.R....Bhavnani S.M.	2013
20	A case of esophageal candidiasis in an adolescent who had frequently received budesonide nebulizing therapy. ( 24224152 )	Kang H.R....Kim Y.J.	2013
21	Relationship between clinical factors and severity of esophageal candidiasis according to Kodsi's classification. ( 23826847 )	Asayama N....Uemura N.	2013
22	Factors associated with esophageal candidiasis and its endoscopic severity in the era of antiretroviral therapy. ( 23555571 )		2013
23	Prevalence and risk factors of esophageal candidiasis in healthy individuals: a single center experience in Korea. ( 23225813 )		2013
24	The potential of photodynamic therapy to treat esophageal candidiasis coexisting with esophageal cancer. ( 24378331 )		2013
25	Association of esophageal candidiasis and squamous cell carcinoma. ( 24371724 )	Delsing C.E....Netea M.G.	2012
26	Pharmacokinetics of micafungin in HIV positive patients with confirmed esophageal candidiasis. ( 21956255 )		2012
27	Eosinophilic esophagitis misdiagnosed twice as esophageal candidiasis. ( 20152316 )	Infante J.M....Lamana L.F.	2010
28	Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection. ( 22096388 )	Vazquez J.A.	2010
29	In vitro activity of anidulafungin and other agents against esophageal candidiasis-associated isolates from a phase 3 clinical trial. ( 20504981 )		2010
30	Esophageal candidiasis in an immunocompetent girl. ( 19718541 )	Hasosah M.Y....Jacobson K.	2009
31	Esophageal candidiasis--an adverse effect of inhaled corticosteroids therapy. ( 19484677 )		2009
32	The resistance to fluconazole in patients with esophageal candidiasis. ( 19466307 )		2009
33	The impact of esophageal candidiasis on hospital charges and costs across patient subgroups. ( 18036287 )	Tong K.B....Seifeldin R.	2008
34	Giardiasis diagnosed on esophageal brush smears in a case of chronic alcoholic liver disease with esophageal candidiasis. ( 18831025 )	Singh D.K....Gondal R.	2008
35	Esophageal candidiasis and Candida colonization in asthma patients on inhaled steroids. ( 18034973 )	Mullaoglu S....Kustimur S.	2007
36	Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection. ( 17243069 )	Skiest D.J....Isaacs R.	2007
37	An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis. ( 17409603 )	Takasawa H....Noda M.	2007
38	Possible aggravation and recovery of slowly progressive type 1 diabetes by onset and resolution of oral and esophageal candidiasis. ( 17878660 )	Goto A....Noda M.	2007
39	Role of posaconazole in the management of oropharyngeal and esophageal candidiasis. ( 18472974 )	Vazquez J.A.	2007
40	Safety and efficacy of posaconazole in the long-term treatment of azole-refractory oropharyngeal and esophageal candidiasis in patients with HIV infection. ( 17507324 )	Vazquez J.A....Isaacs R.	2007
41	Caspofungin-resistant oral and esophageal candidiasis in a patient with AIDS. ( 17148982 )	Jokela JA...Kaur P	2007
42	A murine model of esophageal candidiasis with local characteristic symptoms. ( 17579259 )	Ishibashi H...Abe S	2007
43	Caspofungin in the treatment of azole-refractory esophageal candidiasis in kidney transplant recipients. ( 16757256 )		2006
44	Esophageal candidiasis as a side effect of inhaled fluticasone propionate dry powder: recovery by switching over to hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP). ( 16724573 )		2006
45	Decline in esophageal candidiasis and use of antimycotics in European patients with HIV. ( 15984964 )	Mocroft A....Lundgren J.	2005
46	Esophageal candidiasis. ( 16408552 )	Golub J.S....Johns M.M.	2005
47	Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome. ( 16127030 )	Kartsonis N...Motyl M	2005
48	A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. ( 15472806 )	Krause D.S....Henkel T.	2004
49	Echinocandins: ask not what they can do for esophageal candidiasis--ask what studies of esophageal candidiasis can do for them. ( 15472818 )	Darouiche R.O.	2004
50	Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. ( 15388459 )	Petraitis V....Walsh T.J.	2004

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Genes for Esophageal Candidiasis

Genes related to Esophageal Candidiasis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	15.91	DISEASES inferred ¹⁵
2	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	15.91	DISEASES inferred ¹⁵
3	IARS2	Isoleucyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	15.37	DISEASES inferred ¹⁵
4	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	14.96	DISEASES inferred ¹⁵
5	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	14.86	DISEASES inferred ¹⁵
6	DEFB4A	Defensin Beta 4A	Protein Coding	14.74	DISEASES inferred ¹⁵
7	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	14.39	DISEASES inferred ¹⁵

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Variations for Esophageal Candidiasis

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Expression for Esophageal Candidiasis

Search GEO for disease gene expression data for Esophageal Candidiasis.

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Pathways for Esophageal Candidiasis

Pathways related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ²² Retinol metabolism ³⁷ Voriconazole Pathway, Pharmacokinetics ⁶¹	12.44	CYP2C19 CYP2C9 CYP3A4
2	Linoleic acid metabolism ³⁷ Show member pathways alpha-Linolenic acid metabolism ³⁷ Arachidonic acid metabolism ³⁷	11.72	CYP2C19 CYP2C9 CYP3A4
3	Statin Pathway - Generalized, Pharmacokinetics ⁶¹ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶¹ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶¹ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶¹ Fluvastatin Pathway, Pharmacokinetics ⁶¹ Ibuprofen Pathway, Pharmacokinetics ⁶¹ Pravastatin Pathway, Pharmacokinetics ⁶¹ Rosiglitazone Pathway, Pharmacokinetics ⁶¹ Rosuvastatin Pathway, Pharmacokinetics ⁶¹	11.57	CYP2C19 CYP2C9 CYP3A4
4	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Show member pathways Clozapine Pathway, Pharmacokinetics ⁶¹ Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Gefitinib Pathway, Pharmacokinetics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.5	CYP2C19 CYP2C9 CYP3A4
5	Clomipramine Pathway, Pharmacokinetics ⁶¹ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶¹ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁶ Citalopram Pathway, Pharmacokinetics ⁶¹ Clopidogrel Pathway, Pharmacokinetics ⁶¹ Colchicine Metabolic Pathway ¹ Imipramine/Desipramine Pathway, Pharmacokinetics ⁶¹ Lidocaine metabolism ¹ Olanzapine Pathway, Pharmacokinetics ⁶¹ Paroxetine Pathway, Pharmacokinetics ⁶¹ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶¹ Venlafaxine Pathway, Pharmacokinetics ⁶¹ Verapamil Pathway, Pharmacokinetics ⁶¹	11.4	CYP2C19 CYP2C9 CYP3A4
6	Phenytoin Pathway, Pharmacokinetics ⁶¹ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶¹ Carbamazepine Pathway, Pharmacokinetics ⁶¹ Cyclophosphamide Pathway, Pharmacokinetics ⁶¹ Efavirenz Pathway, Pharmacokinetics ⁶¹ Sorafenib Pharmacokinetics ⁶¹	11.3	CYP2C19 CYP2C9 CYP3A4
7	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.17	CYP2C19 CYP2C9 CYP3A4
8	Nuclear Receptors in Lipid Metabolism and Toxicity ¹	11.09	CYP2C9 CYP3A4
9	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶¹	11.04	CYP2C19 CYP2C9 CYP3A4
10	Caffeine Pathway, Pharmacokinetics ⁶¹ Show member pathways Acetylation ⁶⁶ Caffeine and Theobromine metabolism ¹ Caffeine metabolism ³⁷ estradiol biosynthesis II ¹ Felbamate Metabolism ¹ Gut-Liver Indole Metabolism ¹ Theophylline Pathway, Pharmacokinetics ⁶¹	10.97	CYP2C9 CYP3A4
11	Erlotinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Dasatinib Pathway, Pharmacokinetics ⁶¹	10.9	CYP2C9 CYP3A4
12	Naphthalene metabolism ²²	10.89	CYP2C9 CYP3A4
13	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.8	CYP2C9 CYP3A4
14	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶¹	10.72	CYP2C19 CYP2C9 CYP3A4
15	Constitutive Androstane Receptor Pathway ¹	10.3	CYP2C19 CYP2C9 CYP3A4
16	Losartan Pathway, Pharmacokinetics ⁶¹	10.1	CYP2C9 CYP3A4

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GO Terms for Esophageal Candidiasis

Cellular components related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	8.8	CYP2C19 CYP2C9 CYP3A4

Biological processes related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid metabolic process	GO:0008202	9.63	CYP2C19 CYP2C9 CYP3A4
2	potassium ion import across plasma membrane	GO:1990573	9.58	ATP12A ATP4A
3	potassium ion import	GO:0010107	9.58	ATP12A ATP4A
4	ATP hydrolysis coupled proton transport	GO:0015991	9.57	ATP12A ATP4A
5	organic acid metabolic process	GO:0006082	9.56	CYP2C19 CYP2C9
6	long-chain fatty acid biosynthetic process	GO:0042759	9.55	CYP2C9 CYP3A4
7	epoxygenase P450 pathway	GO:0019373	9.54	CYP2C19 CYP2C9
8	cellular sodium ion homeostasis	GO:0006883	9.52	ATP12A ATP4A
9	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.51	ATP12A ATP4A
10	xenobiotic metabolic process	GO:0006805	9.5	CYP2C19 CYP2C9 CYP3A4
11	cellular potassium ion homeostasis	GO:0030007	9.49	ATP12A ATP4A
12	sodium ion export across plasma membrane	GO:0036376	9.48	ATP12A ATP4A
13	omega-hydroxylase P450 pathway	GO:0097267	9.43	CYP2C19 CYP2C9
14	oxidative demethylation	GO:0070989	9.4	CYP2C9 CYP3A4
15	heterocycle metabolic process	GO:0046483	9.37	CYP2C19 CYP3A4
16	drug metabolic process	GO:0017144	9.33	CYP2C19 CYP2C9 CYP3A4
17	drug catabolic process	GO:0042737	9.26	CYP2C9 CYP3A4
18	exogenous drug catabolic process	GO:0042738	9.13	CYP2C19 CYP2C9 CYP3A4
19	monoterpenoid metabolic process	GO:0016098	8.8	CYP2C19 CYP2C9 CYP3A4

Molecular functions related to Esophageal Candidiasis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.63	CYP2C19 CYP2C9 CYP3A4
2	iron ion binding	GO:0005506	9.61	CYP2C19 CYP2C9 CYP3A4
3	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.54	CYP2C19 CYP2C9 CYP3A4
4	oxygen binding	GO:0019825	9.49	CYP2C19 CYP3A4
5	arachidonic acid epoxygenase activity	GO:0008392	9.48	CYP2C19 CYP2C9
6	monooxygenase activity	GO:0004497	9.43	CYP2C19 CYP2C9 CYP3A4
7	sodium:potassium-exchanging ATPase activity	GO:0005391	9.4	ATP12A ATP4A
8	caffeine oxidase activity	GO:0034875	9.32	CYP2C9 CYP3A4
9	potassium:proton exchanging ATPase activity	GO:0008900	9.16	ATP12A ATP4A
10	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.13	CYP2C19 CYP2C9 CYP3A4
11	steroid hydroxylase activity	GO:0008395	8.8	CYP2C19 CYP2C9 CYP3A4

Sources

Sources for Esophageal Candidiasis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia