MCID: ESP023
MIFTS: 52

Esophageal Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Esophageal Disease

MalaCards integrated aliases for Esophageal Disease:

Name: Esophageal Disease 12 15 17
Esophageal Diseases 54 44 70
Esophageal Disorder 73
Ulcer of Esophagus 70
Esophageal Ulcer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6050
ICD9CM 34 530.9
MeSH 44 D004935
NCIt 50 C3027
SNOMED-CT 67 266497000
ICD10 32 K22.1 K22.9
UMLS 70 C0014852 C0151970

Summaries for Esophageal Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the esophagus.

MalaCards based summary : Esophageal Disease, also known as esophageal diseases, is related to esophagitis, eosinophilic, 1 and esophageal cancer, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Esophageal Disease is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include esophagus, bone and trachea.

Wikipedia : 73 The esophagus (American English) or oesophagus (British English; see spelling differences)... more...

Related Diseases for Esophageal Disease

Diseases related to Esophageal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 esophagitis, eosinophilic, 1 31.0 CCR6 ATP4A ATP12A
2 esophageal cancer 30.9 MIR486-1 MIR423 MIR223 MIR21 MIR199A1 MIR196A1
3 peptic esophagitis 30.6 ATP4A ATP12A
4 immune deficiency disease 30.5 MIR223 MIR21 MIR199A1 MIR196A1 MIR17 H2AC18
5 rectum cancer 30.5 MIR21 MIR17 MIR145 MIR143 MIR139 CEACAM5
6 hernia, hiatus 30.4 ATP4A ATP12A
7 myeloma, multiple 30.4 MIR21 MIR199A1 MIR196A1 MIR17 MIR145 KDM4C
8 esophageal candidiasis 30.4 CCR6 ATP4A ATP12A
9 peptic ulcer perforation 30.3 ATP4A ATP12A
10 mediastinitis 30.3 ATP4A ATP12A
11 thyroid gland disease 30.3 MIR199A1 MIR17 H2AC18 CEACAM5 CCR6
12 esophagus adenocarcinoma 30.3 MIR21 MIR199A1 MIR196A1 MIR145 MIR143 ATP4A
13 active peptic ulcer disease 30.3 ATP4A ATP12A
14 heart disease 30.3 MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR145
15 leukemia, chronic lymphocytic 30.2 MIR486-1 MIR423 MIR223 MIR21 MIR199A1 MIR196A1
16 alcohol use disorder 30.1 MIR199A1 H2AC18 CCR6
17 pancreas disease 30.0 MIR486-1 MIR423 MIR21 MIR199A1 MIR196A1 MIR17
18 genetic gastro-esophageal disease 11.0
19 achalasia 11.0
20 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.9
21 vagus nerve disease 10.6 ATP4A ATP12A
22 necrotizing gastritis 10.6 ATP4A ATP12A
23 scalp dermatosis 10.6 ATP4A ATP12A
24 hemangioma of intra-abdominal structure 10.6 ATP4A ATP12A
25 acquired gastric outlet stenosis 10.6 ATP4A ATP12A
26 lingual goiter 10.6 ATP4A ATP12A
27 displacement of cardia through esophageal hiatus 10.6 ATP4A ATP12A
28 bacterial esophagitis 10.6 ATP4A ATP12A
29 cascade stomach 10.6 ATP4A ATP12A
30 benzylpenicillin allergy 10.6 ATP4A ATP12A
31 duodenal obstruction 10.6 CEACAM5 ATP4A ATP12A
32 pancreatic cystadenoma 10.6 MIR21 MIR196A1 CEACAM5
33 squamous papillomatosis 10.6 CEACAM5 ATP4A ATP12A
34 esophageal tuberculosis 10.6 CEACAM5 ATP4A ATP12A
35 median arcuate ligament syndrome 10.6 ATP4A ATP12A
36 afferent loop syndrome 10.6 ATP4A ATP12A
37 cervix erosion 10.6 ATP4A ATP12A
38 angiodysplasia of intestine 10.6 ATP4A ATP12A
39 hemorrhoid 10.6 CEACAM5 ATP4A ATP12A
40 cervix small cell carcinoma 10.6 MIR199A1 MIR145 MIR143 MIR10B
41 granulomatous gastritis 10.6 ATP4A ATP12A
42 laryngeal tuberculosis 10.6 ATP4A ATP12A
43 fungal esophagitis 10.6 ATP4A ATP12A
44 dieulafoy lesion 10.6 ATP4A ATP12A
45 esophagus melanoma 10.6 ATP4A ATP12A
46 duodenum disease 10.6 MIR196A1 CEACAM5 ATP4A ATP12A
47 cefuroxime allergy 10.6 ATP4A ATP12A
48 rumination disorder 10.6 H2AC18 ATP4A ATP12A
49 microinvasive gastric cancer 10.6 MIR196A1 CEACAM5 ATP4A ATP12A
50 ampulla of vater cancer 10.6 MIR196A1 MIR145 CEACAM5

Comorbidity relations with Esophageal Disease via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Bronchitis
Chronic Kidney Disease Decubitus Ulcer
Deficiency Anemia Duodenitis
Dyskinesia of Esophagus Esophageal Cancer
Esophageal Candidiasis Esophageal Varix
Esophagitis Esophagus Carcinoma in Situ
Heart Disease Hypertension, Essential
Intestinal Obstruction Iron Deficiency Anemia
Mallory-Weiss Syndrome Megaesophagus
Paralytic Ileus Peptic Esophagitis
Protein-Energy Malnutrition Schizophreniform Disorder
Swallowing Disorders

Graphical network of the top 20 diseases related to Esophageal Disease:



Diseases related to Esophageal Disease

Symptoms & Phenotypes for Esophageal Disease

UMLS symptoms related to Esophageal Disease:


nausea and vomiting; constipation; abdominal pain; diarrhea; tinnitus; snoring; dyspepsia; sore throat; icterus; signs and symptoms, digestive; coughing; vertigo/dizziness; equilibration disorder; heartburn; gastrointestinal gas; digestive system symptom

Drugs & Therapeutics for Esophageal Disease

Drugs for Esophageal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
10
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
11
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
12 Methylprednisolone Acetate Phase 4
13 Neuroprotective Agents Phase 4
14 Protective Agents Phase 4
15 Narcotics Phase 4
16 Narcotic Antagonists Phase 4
17 Analgesics, Opioid Phase 4
18 Pharmaceutical Solutions Phase 4
19 Dopamine Agents Phase 4
20 Dopamine Antagonists Phase 4
21
Pantoprazole Approved Phase 3 102625-70-7 4679
22
Rabeprazole Approved, Investigational Phase 3 117976-89-3 5029
23
Nedaplatin Approved, Investigational Phase 3 95734-82-0
24
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
25 Proton Pump Inhibitors Phase 3
26
Lenograstim Approved, Investigational Phase 2 135968-09-1
27
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
28
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
29
leucovorin Approved Phase 2 58-05-9 6006
30
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
31
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
32
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
33
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
34
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
35
Fluorouracil Approved Phase 2 51-21-8 3385
36
Naloxegol Approved Phase 2 854601-70-0
37
Bevacizumab Approved, Investigational Phase 2 216974-75-3
38
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
39
Nimotuzumab Investigational Phase 2 780758-10-3, 828933-61-3
40 Adjuvants, Immunologic Phase 2
41 Immunoglobulins Phase 2
42 Antibodies Phase 2
43 Folate Phase 2
44 Vitamin B9 Phase 2
45 Cytochrome P-450 CYP3A Inhibitors Phase 2
46
Hydroxyitraconazole Phase 2 108222
47 Antifungal Agents Phase 2
48 Anti-Infective Agents Phase 2
49 Cytochrome P-450 Enzyme Inhibitors Phase 2
50 Albumin-Bound Paclitaxel Phase 2

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
2 High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns in Children Completed NCT02002078 Phase 4 methylprednisolon
3 Is the Opioid-induced Pharyngeal and Esophageal Dysfunction Peripherally or Central Mediated? Completed NCT01012960 Phase 4 methylnaltrexone
4 Can Opioid Induced Effects on Esophageal Motility and Lower Esophageal Sphincter be Counteracted by a Dopamine Receptor Antagonist? Completed NCT01191645 Phase 4 naloxone;remifentanil;Sodium Chloride;metoclopramide
5 Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain Withdrawn NCT02569073 Phase 4 Dronabinol;Placebo
6 Efficacy of DA-5204 (Stillen 2X®) for Patients With Gastroesophageal Reflux Disease: A Randomized, Double-blind, Placebo-controlled Pilot Study Completed NCT03998969 Phase 3 Pantoprazole;DA-5204;Placebo
7 Treatment Response of High-dose and Standard-dose Rabeprazole for Gastroesophageal Reflux Disease With Extra-esophageal Manifestations: a Single-center, Randomized, Open-label Trial. Completed NCT04001400 Phase 3 Rabeprazole 20mg bid;Rabeprazole 20mg qd
8 A Prospective Clinical Trial of Improving the Treatment of Thoracic Esophageal Cancer Active, not recruiting NCT01137123 Phase 3 adjuvant chemotherapy
9 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Unknown status NCT03302858 Phase 2
10 Phase II Study of Radiation Therapy With Peptide Specific CTL Therapy in Treating Patients With Unresectable, Advanced or Recurrent Esophageal Cancer Unknown status NCT03011255 Phase 2
11 Phase II Study of Neoadjuvant Anti-PD-1 Antibody SHR-1210 and Radiation in Resectable Esophageal Squamous Cell Carcinoma Unknown status NCT03200691 Phase 2 anti-PD-1 antibody SHR-1210
12 A Phase II Study Of Paclitaxel-Based Chemoradiotherapy Regimen With Selective Surgical Salvage For Resectable Locoregionally Advanced Carcinoma Of The Esophagus Completed NCT00069953 Phase 2 cisplatin;fluorouracil;paclitaxel
13 Phase II Study of Radiation Therapy With Anti-PD-1 Antibody SHR-1210 in Treating Patients With Unresectable Esophageal Cancer Completed NCT03187314 Phase 2 Radiation;SHR-1210
14 Effect of Ocoxin®-Viusid® Nutritional Supplement on the Quality of Life of Patients With Advanced Stomach Cancer and Esophagogastric Junction. Phase II Clinical Trial. Recruiting NCT03549494 Phase 2
15 Phase II Study of Concurrent Chemoradiotherapy With Itraconazole in Treating Patients With Locally Advanced Esophageal Squamous Cancer Recruiting NCT04481100 Phase 2 itraconazole
16 Phase II Study of Pre-Operative Chemotherapy With Taxol, Cisplatin, and 5-Fluorouracil Followed by G-CSF in Patients With Resectable Local-Regional Carcinoma of Esophagus Terminated NCT00208936 Phase 2 Taxol, Cisplatin, 5-Fluorouracil, G-CSF
17 Movantik for Opioid-Related Esophageal Disorders Terminated NCT02998606 Phase 2 Naloxegol;Placebo Oral Capsule
18 A Phase II Trial of Erlotinib and Avastin in Previously Treated Patients With Cancer of the Esophagus or Gastroesophageal Junction Terminated NCT00442507 Phase 2 Erlotinib;Avastin
19 Prospective Study of the Effects of Non-dependent Lung High Frequency Positive Pressure Ventilation on the Right Ventricular Function for Thoracotomy Completed NCT01019993 Phase 1
20 Perioperative Versus Preoperative Chemotherapy With Surgery in Patients With Locoregional Squamous Carcinoma of Esophagus Completed NCT01225523 Phase 1 Paclitaxel; Cisplatin; 5-Fluorouracil;Paclitaxel; Cisplatin; 5-Fluorouracil; Capecitabine
21 A Phase I Study of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology Active, not recruiting NCT03330028 Phase 1 Dexamethasone;Diphenhydramine;Famotidine;Mitomycin C;Cisplatin;Paclitaxel
22 Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index: A Prospective Multicenter Study Unknown status NCT00939263
23 The Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Oesophageal Pain Hypersensitivity in Healthy Volunteers Unknown status NCT02620176
24 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
25 Endoscopic Submucosal Tunnel Dissection for Endoluminal Partial Myotomy of the Lower Esophageal Sphincter in Patients With Spastic Esophageal Disorders Such as Achalasia Unknown status NCT02425033
26 Predictive Factors and Outcome of Esophageal Ulcers After Endoscopic Treatment of Esophageal Varices; Multicenter Study Unknown status NCT02256046
27 A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain) Unknown status NCT00471796
28 Evaluation of Esophageal Damage During Conventional Pulmonary Vein Ablation Procedures and Potential Strategies to Protect the Esophagus. Pilot Study. Unknown status NCT03832959
29 Endosonography-Guided Fine-Needle-Aspiration (EUS-FNA) Versus Key Hole Biopsy (KHB) in Diagnostics of Upper Gastrointestinal Submucosal Tumors - a Randomized Trial Unknown status NCT02025244
30 Indications and Outcomes of Gastrointestinal Endoscopic Ultrasound in Tanta-Egypt: Initial Experience. Unknown status NCT03267355
31 A Novel Disposable Transnasal Esophagoscope: a Prospective Pilot Trial of Feasibility, Safety and Tolerance Completed NCT01360515
32 Clinical and Molecular Assessment of Men With High Risk for Esophageal Disorders Completed NCT02476513
33 Drop in Gastroscopy - Experience After 9 Months Completed NCT00977678
34 Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux Completed NCT00584259
35 Safety and Feasibility of TachoSil®: Application on Esophageal Anastomoses Completed NCT02105506 Tachosil patch
36 Quality of Life Among Patients With Chronic Esophageal Disorders : Spanish Translation and Validation of the Survey "Northwestern Esophageal Quality of Life Scale" in Hispanics Completed NCT02959424
37 Factors Linked to Outcomes After Esophageal Cancer Surgery: a Multicenter National Study Completed NCT01927016
38 The Role of Endoscopic Confocal Microscopy in Diagnosing Colorectal Cancer and Other Gastrointestinal Pathologies in Vivo Completed NCT00874263
39 The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy Completed NCT03859557
40 Impact of Antibiotic Prophylaxis and Conditioning Modalities in Per Oral Endoscopic Myotomy for Esophageal Motor Disorders Completed NCT03944863 Antibiotics
41 Oesophageal Protection: a Novel Approach to Improving the Safety of Catheter Ablation for Atrial Fibrillation. Recruiting NCT03819946
42 National Oesophageal and Gastric Carcinomas Data Base Construction: the FREGAT (French EsoGastric Tumours) Data Base Recruiting NCT02526095
43 CDx Study 906: The Clinical Utility of WATS3D (Wide Area Transepithelial Sampling With Computer-Assisted 3-Dimensional Analysis): A 5- Year Prospective Registry Recruiting NCT04312633
44 A Prospective Study to Evaluate the Safety and Feasibility of an Endoluminal-suturing Device (Endomina TM) as an Aid for Diverticulum Treatment Recruiting NCT03609073
45 Radiofrequency Ablation for the Treatment of Large Symptomatic Heterotopic Gastric Mucosa - a Prospective Randomized Sham-controlled Trial - the RAGE Study Recruiting NCT03518905
46 Esophageal Cancer Risk Registry Recruiting NCT00260585
47 The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Registry Recruiting NCT02988934
48 EndoVE endosCopic Treatment for Oesophageal and Gastric canceR Recruiting NCT04649372
49 Measurement of Contractile Activity and Distensibility of the Esophago-gastric Junction, of the Esophagus and of the Pylorus: Normal Values in Controls Under General Anesthesia (NormaFLIP Study) Recruiting NCT02905669
50 Esophageal Squamous Cell Carcinoma African Prevention Research (ESCCAPE) Cytosponge™ Feasibility Study Active, not recruiting NCT04090554

Search NIH Clinical Center for Esophageal Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Lidocaine
LIDOCAINE HCL PWDR
Lidocaine Hydrochloride
LIDOCAINE PWDR

Cochrane evidence based reviews: esophageal diseases

Genetic Tests for Esophageal Disease

Anatomical Context for Esophageal Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Esophageal Disease:

19
Esophagus

MalaCards organs/tissues related to Esophageal Disease:

40
Bone, Trachea, Heart, Colon, Skin, Cervix, Lymph Node

Publications for Esophageal Disease

Articles related to Esophageal Disease:

(show top 50) (show all 1213)
# Title Authors PMID Year
1
Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques. 61 54
10036123 1998
2
Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells. 61
33314197 2021
3
Expression of Adhesion Molecules in a Gastroduodenal Reflux Murine Model. 61
33774002 2021
4
Esophageal microbiome in active eosinophilic esophagitis and changes induced by different therapies. 61
33782490 2021
5
EOSINOPHILIC ESOPHAGITIS AND ACHALASIA: TWO DISTINCT NOSOLOGIC ENTITIES OR A POSSIBLE ETIOPATHOGENIC ASSOCIATION? 61
33647902 2021
6
The Modern Age of POEM: the Past, Present and Future of Per-Oral Endoscopic Myotomy. 61
33140317 2021
7
Exploring the concept of centralization of surgery for benign esophageal diseases: a Delphi based consensus from the European Society for Diseases of the Esophagus. 61
33621318 2021
8
[Initial experience of robot-assisted minimally invasive McKeown esophagectomy]. 61
33570350 2021
9
ELNet:Automatic classification and segmentation for esophageal lesions using convolutional neural network. 61
33129148 2021
10
Giant IgG4-Related Pseudotumor of the Esophagus Resected with Endoscopic Submucosal Dissection: A Case Report and Review of the Literature. 61
33432560 2021
11
Microbiome of the Aerodigestive Tract in Health and Esophageal Disease. 61
33236315 2021
12
Eosinophilic Vulvar Leukoderma. 61
33708084 2021
13
Validation of the Short-Form Esophageal Hypervigilance and Anxiety Scale. 61
33348046 2021
14
Venous thromboembolism in benign esophageal surgery patients: potential cost effectiveness of Caprini risk stratification. 61
33492505 2021
15
Esophageal hypervigilance is prevalent across gastroesophageal reflux disease presentations. 61
33432708 2021
16
Mucosal impedance for esophageal disease: evaluating the evidence. 61
32588457 2020
17
Inflammatory conditions of the esophagus: an update. 61
32783223 2020
18
Relationship of the Esophageal Microbiome and Tissue Gene Expression and Links to the Oral Microbiome: A Randomized Clinical Trial. 61
33512805 2020
19
Impedance in the evaluation of the esophagus. 61
32557676 2020
20
Composition and consistence of the bacterial microbiome in upper, middle and lower esophagus before and after Lugol's iodine staining in the esophagus cancer screening. 61
33169656 2020
21
Characterizing caspase-1 involvement during esophageal disease progression. 61
32613271 2020
22
The functional lumen imaging probe in gastrointestinal disorders: the past, present, and future. 61
32814368 2020
23
Proton-pump Inhibitor Response Prediction Using Esophageal microRNAs in Children With Eosinophilic Esophagitis. 61
33003164 2020
24
Effectiveness of allergy testing in milk induced eosinophilic esophagitis. Description and follow-up of patients. 61
32674848 2020
25
The EsoCap-system - An innovative platform to drug targeting in the esophagus. 61
32781172 2020
26
Immunohistochemical markers for eosinophilic esophagitis. 61
33032462 2020
27
Impact of COVID-19 outbreak on esophageal cancer surgery in Northern Italy: lessons learned from a multicentric snapshot. 61
33245104 2020
28
Incidence of GERD, esophagitis, Barrett's esophagus, and esophageal adenocarcinoma after bariatric surgery. 61
32711954 2020
29
Differentiating Delayed Esophageal Clearance From Reflux in Scleroderma. 61
33365221 2020
30
Mucosal impedance testing: A new diagnostic testing in gastroesophageal reflux disease. 61
31542333 2020
31
Esophageal motility disorders in children with dysphagia: the utility of the Chicago classification. 61
33054306 2020
32
MicroRNA expression profiles in the esophagus of children with caustic stenosis: A pathway towards esophageal cancer? 61
32111433 2020
33
Documenting the Journey of Patients with Eosinophilic Esophagitis and the Impact of the Disease on Patients and their Caregivers: A Cross-sectional, Qualitative Research Study. 61
32880822 2020
34
Secondary adenocarcinoma of the urinary bladder attributed to metastatic gastroesophageal cancer. 61
33049197 2020
35
Self-expanding metal stent in esophageal perforations and anastomotic leaks. 61
33001339 2020
36
Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma. 61
33133384 2020
37
Esophageal emergencies: another important cause of acute chest pain. 61
33034721 2020
38
Effects of proton pump inhibitor use on the esophageal microbial community. 61
32967615 2020
39
The use of impedance planimetry (Endoscopic Functional Lumen Imaging Probe, EndoFLIP® ) in the gastrointestinal tract: A systematic review. 61
32856765 2020
40
EndoFLIP in the Esophagus: Assessing Sphincter Function, Wall Stiffness, and Motility to Guide Treatment. 61
32718562 2020
41
Interaction Between Ethnicity and Helicobacter pylori Infection in the Occurrence of Reflux Disease. 61
31651573 2020
42
Minimally Invasive Ivor Lewis Esophagectomy (MILE): technique and outcomes of 100 consecutive cases. 61
32253561 2020
43
Characterization of Geriatric Dysphagia Diagnoses in Age-Based Cohorts. 61
32685871 2020
44
Esophageal foreign bodies: observational cohort study and factors associated with recurrent impaction. 61
32243348 2020
45
[Therapeutic Response to 20 mg of Esomeprazole Twice Daily in Patients with Gastroesophageal Reflux Disease-related Non-cardiac Chest Pain: An Open-Label Randomized Pilot Study]. 61
32581204 2020
46
Adversarial convolutional network for esophageal tissue segmentation on OCT images. 61
32637244 2020
47
Treatment of eosinophilic esophagitis with diets. 61
31760737 2020
48
Measurements of Duodenal Mucosal Integrity Are Altered in Celiac Disease. 61
31351133 2020
49
Advances in the surgical treatment of esophageal cancer since 1965. 61
32490339 2020
50
The insidious presentation and challenging management of esophageal perforation following diagnostic and therapeutic interventions. 61
32642181 2020

Variations for Esophageal Disease

Expression for Esophageal Disease

Search GEO for disease gene expression data for Esophageal Disease.

Pathways for Esophageal Disease

Pathways related to Esophageal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 MIR423 MIR223 MIR21 MIR200B MIR199A1 MIR17
2 10.07 MIR199A1 MIR145

GO Terms for Esophageal Disease

Cellular components related to Esophageal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 MIR423 MIR223 MIR21 MIR17 MIR145 MIR143
2 extracellular space GO:0005615 9.36 MIR486-1 MIR423 MIR223 MIR21 MIR199A1 MIR17

Biological processes related to Esophageal Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.57 MIR199A1 MIR17
2 negative regulation of myotube differentiation GO:0010832 9.56 MIR200B CEACAM5
3 negative regulation of angiogenesis GO:0016525 9.56 MIR21 MIR200B MIR145 MIR143
4 sodium ion export across plasma membrane GO:0036376 9.55 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 9.54 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.52 ATP4A ATP12A
7 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.51 MIR199A1 MIR17
8 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.5 MIR21 MIR199A1 MIR145
9 positive regulation of metalloendopeptidase activity GO:1904685 9.49 MIR21 MIR17
10 angiotensin-activated signaling pathway GO:0038166 9.48 MIR145 MIR143
11 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.46 MIR21 MIR17
12 gene silencing by miRNA GO:0035195 9.44 MIR486-1 MIR423 MIR223 MIR21 MIR200B MIR199A1
13 aorta smooth muscle tissue morphogenesis GO:0060414 9.43 MIR145 MIR143
14 miRNA mediated inhibition of translation GO:0035278 9.43 MIR21 MIR200B MIR17 MIR145 MIR144 MIR10B
15 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.4 MIR17 MIR143
16 regulation of phenotypic switching GO:1900239 9.37 MIR145 MIR143
17 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.16 MIR145 MIR143

Molecular functions related to Esophageal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.56 MIR21 MIR200B MIR17 MIR145 MIR144 MIR143
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR423 MIR223 MIR21 MIR200B MIR199A1 MIR196A1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 9.16 ATP4A ATP12A

Sources for Esophageal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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