MCID: ESP023
MIFTS: 52

Esophageal Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Esophageal Disease

MalaCards integrated aliases for Esophageal Disease:

Name: Esophageal Disease 12 15 17
Esophageal Diseases 54 43 71
Esophageal Disorder 74
Ulcer of Esophagus 71
Esophageal Ulcer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6050
ICD9CM 34 530 530.9
MeSH 43 D004935
NCIt 49 C3027
SNOMED-CT 67 37657006
ICD10 32 K22.1 K22.9
UMLS 71 C0014852 C0151970

Summaries for Esophageal Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the esophagus.

MalaCards based summary : Esophageal Disease, also known as esophageal diseases, is related to esophagitis, eosinophilic, 1 and esophageal cancer, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Esophageal Disease is MIR196A1 (MicroRNA 196a-1), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. The drugs Carvedilol and Alendronate have been mentioned in the context of this disorder. Affiliated tissues include esophagus, lung and heart.

Wikipedia : 74 The esophagus (American English) or oesophagus (British English; see spelling differences)... more...

Related Diseases for Esophageal Disease

Diseases related to Esophageal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 384)
# Related Disease Score Top Affiliating Genes
1 esophagitis, eosinophilic, 1 31.4 MIR223 ATP4A ATP12A
2 esophageal cancer 31.0 MIR93 MIR486-1 MIR423 MIR223 MIR21 MIR199A1
3 peptic esophagitis 30.9 ATP4A ATP12A
4 gastrojejunal ulcer 30.8 ATP4A ATP12A
5 rumination disorder 30.8 ATP4A ATP12A
6 esophageal tuberculosis 30.7 ATP4A ATP12A
7 myeloma, multiple 30.5 MIR93 MIR483 MIR21 MIR199A1 MIR196A1 MIR17
8 esophageal candidiasis 30.5 ATP4A ATP12A
9 rectum cancer 30.5 MIR483 MIR21 MIR196A1 MIR17 MIR145 MIR143
10 peptic ulcer perforation 30.5 ATP4A ATP12A
11 idiopathic interstitial pneumonia 30.5 MIR423 MIR338 MIR21 MIR199A1
12 esophagus adenocarcinoma 30.4 MIR21 MIR196A1 MIR145 MIR143 ATP4A ATP12A
13 pulmonary disease, chronic obstructive 30.4 MIR93 MIR423 MIR199A1 MIR144 ATP12A
14 viral esophagitis 30.3 ATP4A ATP12A
15 hernia, hiatus 30.3 ATP4A ATP12A
16 mediastinitis 30.3 ATP4A ATP12A
17 active peptic ulcer disease 30.2 ATP4A ATP12A
18 leukemia, chronic lymphocytic 30.2 MIR486-1 MIR483 MIR423 MIR338 MIR223 MIR21
19 thyroid gland disease 30.2 MIR486-1 MIR423 MIR338 MIR21 MIR199A1 MIR196A1
20 multiple endocrine neoplasia, type i 30.2 MIR483 ATP4A ATP12A
21 body mass index quantitative trait locus 11 30.2 MIR486-1 MIR483 MIR423 MIR223 MIR21 MIR199A1
22 colorectal cancer 30.0 MIR93 MIR483 MIR338 MIR223 MIR21 MIR200B
23 connective tissue disease 30.0 MIR486-1 MIR483 MIR423 MIR338 MIR223 MIR21
24 bile reflux 30.0 ATP4A ATP12A
25 pancreas disease 29.9 MIR93 MIR486-1 MIR483 MIR423 MIR338 MIR21
26 genetic gastro-esophageal disease 12.1
27 achalasia 11.4
28 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.8
29 pancreatic vasoactive intestinal peptide producing tumor 10.8 ATP4A ATP12A
30 hemangioma of intra-abdominal structure 10.8 ATP4A ATP12A
31 duodenum cancer 10.8 MIR196A1 MIR145 CEACAM5
32 displacement of cardia through esophageal hiatus 10.8 ATP4A ATP12A
33 gastric hemangioma 10.8 ATP4A ATP12A
34 acquired gastric outlet stenosis 10.8 ATP4A ATP12A
35 angiodysplasia of intestine 10.8 ATP4A ATP12A
36 benzylpenicillin allergy 10.8 ATP4A ATP12A
37 median arcuate ligament syndrome 10.8 ATP4A ATP12A
38 granulomatous gastritis 10.8 ATP4A ATP12A
39 duodenal obstruction 10.8 CEACAM5 ATP4A ATP12A
40 bacterial esophagitis 10.8 ATP4A ATP12A
41 lingual goiter 10.8 ATP4A ATP12A
42 cascade stomach 10.8 ATP4A ATP12A
43 squamous papillomatosis 10.8 CEACAM5 ATP4A ATP12A
44 serous cystadenocarcinoma 10.8 MIR199A1 MIR139 MIR10B
45 fungal esophagitis 10.8 ATP4A ATP12A
46 hemorrhoid 10.8 CEACAM5 ATP4A ATP12A
47 gastric gastrinoma 10.8 ATP4A ATP12A
48 fungal gastritis 10.8 ATP4A ATP12A
49 superior mesenteric artery syndrome 10.8 ATP4A ATP12A
50 rectum adenocarcinoma 10.8 MIR143 KDM4C CEACAM5

Comorbidity relations with Esophageal Disease via Phenotypic Disease Network (PDN): (show all 24)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Bronchitis
Decubitus Ulcer Deficiency Anemia
Duodenitis Dyskinesia of Esophagus
Esophageal Cancer Esophageal Candidiasis
Esophageal Varix Esophagitis
Esophagus Carcinoma in Situ Heart Disease
Hypertension, Essential Intestinal Obstruction
Iron Deficiency Anemia Mallory-Weiss Syndrome
Megaesophagus Paralytic Ileus
Peptic Esophagitis Protein-Energy Malnutrition
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Esophageal Disease:



Diseases related to Esophageal Disease

Symptoms & Phenotypes for Esophageal Disease

UMLS symptoms related to Esophageal Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, tinnitus, snoring, sore throat, icterus, signs and symptoms, digestive, coughing, vertigo/dizziness, equilibration disorder, dyspepsia, heartburn, gastrointestinal gas, digestive system symptom

Drugs & Therapeutics for Esophageal Disease

Drugs for Esophageal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
11
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
12
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
15
Clarithromycin Approved Phase 4 81103-11-9 84029
16
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
17
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
18
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
19 Adrenergic alpha-Antagonists Phase 4
20 Adrenergic Antagonists Phase 4
21 Antioxidants Phase 4
22 Antihypertensive Agents Phase 4
23 Adrenergic beta-Antagonists Phase 4
24 Vasodilator Agents Phase 4
25 Calcium, Dietary Phase 4
26 calcium channel blockers Phase 4
27 Adrenergic Agents Phase 4
28 Methylprednisolone Acetate Phase 4
29 Neuroprotective Agents Phase 4
30 Protective Agents Phase 4
31 Pharmaceutical Solutions Phase 4
32 Dopamine Antagonists Phase 4
33 Dopamine Agents Phase 4
34 Dopamine D2 Receptor Antagonists Phase 4
35 Gastrointestinal Agents Phase 4
36 Proton Pump Inhibitors Phase 4
37 Anti-Ulcer Agents Phase 4
38 Antacids Phase 4
39
Rabeprazole Approved, Investigational Phase 3 117976-89-3 5029
40
Pantoprazole Approved Phase 3 102625-70-7 4679
41
Nedaplatin Approved, Investigational Phase 3 95734-82-0
42
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
43
Lenograstim Approved, Investigational Phase 2 135968-09-1
44
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
45
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
46
leucovorin Approved Phase 2 58-05-9 6006 143
47
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
48
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
49
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
50
Fluorouracil Approved Phase 2 51-21-8 3385

Interventional clinical trials:

(show top 50) (show all 86)
# Name Status NCT ID Phase Drugs
1 Banding Ligation With Carvedilol vs. Carvedilol for the Prevention of First Bleeding in Cirrhotics With Moderate Varices Unknown status NCT01383044 Phase 4 carvedilol
2 Can Alendronate Suppress Aortic and Coronary Artery Calcification and Improve Bone Mineral Density in Chronic Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
3 High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns in Children Completed NCT02002078 Phase 4 methylprednisolon
4 Is the Opioid-induced Pharyngeal and Esophageal Dysfunction Peripherally or Central Mediated? Completed NCT01012960 Phase 4 methylnaltrexone
5 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
6 Can Opioid Induced Effects on Esophageal Motility and Lower Esophageal Sphincter be Counteracted by a Dopamine Receptor Antagonist? Completed NCT01191645 Phase 4 naloxone;remifentanil;Sodium Chloride;metoclopramide
7 Radiofrequency Ablation for the Treatment of Large Symptomatic Heterotopic Gastric Mucosa - a Prospective Randomized Sham-controlled Trial - the RAGE Study Recruiting NCT03518905 Phase 4
8 Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality Recruiting NCT02047994 Phase 4 Triple therapy
9 Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE) Not yet recruiting NCT04149470 Phase 4 Omeprazole 20mg BID
10 Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain Withdrawn NCT02569073 Phase 4 Dronabinol;Placebo
11 Treatment Response of High-dose and Standard-dose Rabeprazole for Gastroesophageal Reflux Disease With Extra-esophageal Manifestations: a Single-center, Randomized, Open-label Trial. Completed NCT04001400 Phase 3 Rabeprazole 20mg bid;Rabeprazole 20mg qd
12 Efficacy of DA-5204 (Stillen 2X®) for Patients With Gastroesophageal Reflux Disease: A Randomized, Double-blind, Placebo-controlled Pilot Study Completed NCT03998969 Phase 3 Pantoprazole;DA-5204;Placebo
13 A Prospective Clinical Trial of Improving the Treatment of Thoracic Esophageal Cancer Active, not recruiting NCT01137123 Phase 3 adjuvant chemotherapy
14 Phase II Study of Radiation Therapy With Peptide Specific CTL Therapy in Treating Patients With Unresectable, Advanced or Recurrent Esophageal Cancer Unknown status NCT03011255 Phase 2
15 A Double Blinded Randomized Placebo-controlled Trial of Intravenous QAX576 in the Treatment of Eosinophilic Esophagitis (EoE) Completed NCT01022970 Phase 2 QAX576 placebo;QAX576
16 A Phase II Study Of Paclitaxel-Based Chemoradiotherapy Regimen With Selective Surgical Salvage For Resectable Locoregionally Advanced Carcinoma Of The Esophagus Completed NCT00069953 Phase 2 cisplatin;fluorouracil;paclitaxel
17 Phase II Study of Radiation Therapy With Anti-PD-1 Antibody SHR-1210 in Treating Patients With Unresectable Esophageal Cancer Recruiting NCT03187314 Phase 2 Radiation;SHR-1210
18 Phase II Study of Neoadjuvant Anti-PD-1 Antibody SHR-1210 and Radiation in Resectable Esophageal Squamous Cell Carcinoma Recruiting NCT03200691 Phase 2 anti-PD-1 antibody SHR-1210
19 Phase Ib, Open-label, Single-arm, Multicenter Study to Evaluate Safety and Efficacy of SCT200 in Patients With Advanced Esophageal Squamous Cell Carcinoma Progressed Following Treatment With Taxane/Platinum/Fluorouracil Recruiting NCT03817567 Phase 1, Phase 2 recombinant anti-EGFR monoclonal antibody
20 Effect of Ocoxin®-Viusid® Nutritional Supplement on the Quality of Life of Patients With Advanced Stomach Cancer and Esophagogastric Junction. Phase II Clinical Trial. Recruiting NCT03549494 Phase 2
21 FLUTicasone in Eosinophilic Esophagitis (FLUTE): A Randomized, Double-blind, Placebo-controlled, Dose-ranging, and Maintenance Study of APT-1011 in Subjects With Eosinophilic Esophagitis Active, not recruiting NCT03191864 Phase 2 APT-1011;Placebo
22 Phase II Study of Pre-Operative Chemotherapy With Taxol, Cisplatin, and 5-Fluorouracil Followed by G-CSF in Patients With Resectable Local-Regional Carcinoma of Esophagus Terminated NCT00208936 Phase 2 Taxol, Cisplatin, 5-Fluorouracil, G-CSF
23 A Phase II Trial of Erlotinib and Avastin in Previously Treated Patients With Cancer of the Esophagus or Gastroesophageal Junction Terminated NCT00442507 Phase 2 Erlotinib;Avastin
24 Movantik for Opioid-Related Esophageal Disorders Terminated NCT02998606 Phase 2 Naloxegol;Placebo Oral Capsule
25 Phase II Study of Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
26 Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment in the Management of Benign Esophageal Pathology: A Randomized Controlled Trial Withdrawn NCT02751333 Phase 2
27 Determination of Intestinal Permeability and Response to Treatment in Patients With Eosinophilic Esophagitis Completed NCT01641913 Phase 1
28 Prospective Study of the Effects of Non-dependent Lung High Frequency Positive Pressure Ventilation on the Right Ventricular Function for Thoracotomy Completed NCT01019993 Phase 1
29 Perioperative Versus Preoperative Chemotherapy With Surgery in Patients With Locoregional Squamous Carcinoma of Esophagus Completed NCT01225523 Phase 1 Paclitaxel; Cisplatin; 5-Fluorouracil;Paclitaxel; Cisplatin; 5-Fluorouracil; Capecitabine
30 Can Detection of Fragments of Cleaved E-cadherin in Tissue and/or Blood be of Value for Identifying and Monitoring Patients With PPI-responsive Heartburn? Completed NCT01149395 Phase 1 Dexlansoprazole
31 A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of RMC-4630 Monotherapy in Adult Participants With Relapsed/Refractory Solid Tumors Recruiting NCT03634982 Phase 1 RMC-4630
32 A Phase I Study of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology Active, not recruiting NCT03330028 Phase 1 Dexamethasone;Diphenhydramine;Famotidine;Mitomycin C;Cisplatin;Paclitaxel
33 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
34 Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index: A Prospective Multicenter Study Unknown status NCT00939263
35 Indications and Outcomes of Gastrointestinal Endoscopic Ultrasound in Tanta-Egypt: Initial Experience. Unknown status NCT03267355
36 Immunologic Factors Correlating With Cyclooxygenase and Nitric Oxide Synthase in Reflux Esophagitis and Barrett’s Esophagus Unknown status NCT00155805
37 Predictive Factors and Outcome of Esophageal Ulcers After Endoscopic Treatment of Esophageal Varices; Multicenter Study Unknown status NCT02256046
38 The Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Oesophageal Pain Hypersensitivity in Healthy Volunteers Unknown status NCT02620176
39 Endoscopic Submucosal Tunnel Dissection for Endoluminal Partial Myotomy of the Lower Esophageal Sphincter in Patients With Spastic Esophageal Disorders Such as Achalasia Unknown status NCT02425033
40 Endosonography-Guided Fine-Needle-Aspiration (EUS-FNA) Versus Key Hole Biopsy (KHB) in Diagnostics of Upper Gastrointestinal Submucosal Tumors - a Randomized Trial Unknown status NCT02025244
41 Palliation of Malignant Dysphagia With Spray Cryotherapy in Patients With Advanced Esophageal Cancer: A Pilot Study Unknown status NCT02606396
42 Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux Completed NCT00584259
43 A Novel Disposable Transnasal Esophagoscope: a Prospective Pilot Trial of Feasibility, Safety and Tolerance Completed NCT01360515
44 Clinical and Molecular Assessment of Men With High Risk for Esophageal Disorders Completed NCT02476513
45 Safety and Feasibility of TachoSil®: Application on Esophageal Anastomoses Completed NCT02105506 Tachosil patch
46 Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease Completed NCT03347903
47 An Open, Serial-Panel, Multiple-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of L-743,872 in Patients With Candida Esophagitis Completed NCT00005921 L-743,872
48 Impact of Antibiotic Prophylaxis and Conditioning Modalities in Per Oral Endoscopic Myotomy for Esophageal Motor Disorders Completed NCT03944863 Antibiotics
49 Is Screening for Esophageal Pathology in Asymptomatic Patients Post-Treatment for Head and Neck Cancer Beneficial? Completed NCT00583934
50 Drop in Gastroscopy - Experience After 9 Months Completed NCT00977678

Search NIH Clinical Center for Esophageal Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Lidocaine
LIDOCAINE HCL PWDR
Lidocaine Hydrochloride
LIDOCAINE PWDR

Cochrane evidence based reviews: esophageal diseases

Genetic Tests for Esophageal Disease

Anatomical Context for Esophageal Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Esophageal Disease:

19
Esophagus

MalaCards organs/tissues related to Esophageal Disease:

40
Lung, Heart, Colon, Bone, Trachea, Liver, Thyroid

Publications for Esophageal Disease

Articles related to Esophageal Disease:

(show top 50) (show all 1153)
# Title Authors PMID Year
1
Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques. 54 61
10036123 1998
2
Cholecystectomy during esophagectomy is safe but unnecessary. 61
30618322 2020
3
Valuing innovative endoscopic techniques: endoscopic suturing to prevent stent migration for benign esophageal disease. 61
31449789 2020
4
Better view by detachable string magnetically controlled capsule endoscopy for esophageal observation: a retrospective comparative study. 61
32008045 2020
5
Tips for the Budding Esophagologist. 61
31813062 2019
6
Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. 61
31796739 2019
7
Contribution of magnetic resonance imaging to the management of esophageal diseases: A systematic review. 61
31563109 2019
8
Hiatal Hernia is More Frequent than Expected in Bariatric Patients. Intraoperative Findings during Laparoscopic Sleeve Gastrectomy. 61
31928584 2019
9
Gastrointestinal involvement in systemic sclerosis: an update. 61
31389815 2019
10
Treatment of eosinophilic esophagitis with diets: an update. 61
31760737 2019
11
[Eosinophilic Esophagitis Update: New Guidelines of the European Study Group EUREOS]. 61
31739353 2019
12
Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease. 61
31760496 2019
13
Clinical translational application of Raman spectroscopy to advance Benchside biochemical characterization to bedside diagnosis of esophageal diseases. 61
31124184 2019
14
Interaction Between Ethnicity and Helicobacter pylori Infection in the Occurrence of Reflux Disease. 61
31651573 2019
15
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. 61
31527586 2019
16
Mucosal impedance testing: A new diagnostic testing in gastroesophageal reflux disease. 61
31542333 2019
17
Associations of the microbiome and esophageal disease. 61
31489225 2019
18
Role and safety of fundoplication in esophageal disease and dysmotility syndromes. 61
31489228 2019
19
[Advances in esophageal microbiota and esophageal related diseases]. 61
31434444 2019
20
The changing landscape of esophageal disease. 61
31489223 2019
21
Innovative and Contemporary Interventional Therapies for Esophageal Diseases. 61
31219926 2019
22
Microbiota of the Oropharynx and Endoscope Compared to the Esophagus. 61
31308485 2019
23
Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. 61
30725296 2019
24
GI Manifestations With a Focus on the Esophagus: Recent Progress in Understanding Pathogenesis. 61
31270707 2019
25
Measurements of Duodenal Mucosal Integrity Are Altered in Celiac Disease. 61
31351133 2019
26
An Operable, Portable, and Disposable Ultrathin Endoscope for Evaluation of the Upper Gastrointestinal Tract. 61
30684078 2019
27
Clinical management of eosinophilic esophagitis - a nationwide survey among gastroenterologists in Germany. 61
31170743 2019
28
[Emerging Issues in Esophageal Motility Diseases]. 61
31234622 2019
29
The Difficult Esophageal Conduit. 61
31047036 2019
30
Efficacy and risk profile of self-expandable stents in the management of pediatric esophageal pathology. 61
30890268 2019
31
Evaluation of Esophageal Contraction Reserve Using HRM in Symptomatic Esophageal Disease. 61
30920423 2019
32
CLINICAL AND ENDOSCOPIC EVALUATION IN PATIENTS WITH GASTROESOPHAGEAL SYMPTOMS. 61
31141065 2019
33
Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma. 61
31143067 2019
34
Does DeMeester score still define GERD? 61
30561585 2019
35
Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. 61
30996235 2019
36
Detachable string magnetically controlled capsule endoscopy for complete viewing of the esophagus and stomach. 61
30822803 2019
37
Barium esophagogram in various esophageal diseases: A pictorial essay. 61
31367085 2019
38
Super-achromatic optical coherence tomography capsule for ultrahigh-resolution imaging of esophagus. 61
30302923 2019
39
Clinical features and prognosis of canine megaesophagus in Japan. 61
30626762 2019
40
Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry. 61
30081222 2019
41
The dysphagia stress test for rapid assessment of swallowing difficulties in esophageal conditions. 61
30474165 2019
42
Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice. 61
30791784 2019
43
A multilayer scaffold design with spatial arrangement of cells to modulate esophageal tissue growth. 61
29717817 2019
44
Incidence and treatment of mediastinal leakage after esophagectomy: Insights from the multicenter study on mediastinal leaks. 61
30686903 2019
45
Combined airway and esophageal stents implantation for malignant tracheobronchial and esophageal disease: A STROBE-compliant article. 61
30653162 2019
46
An unusual onset of Crohn's disease with oral aphthosis, giant esophageal ulcers and serological markers of cytomegalovirus and herpes virus infection: a case report and review of the literature. 61
31658341 2019
47
Mediastinal abscess, an unusual way of presentation of eosinophilic esophagitis. 61
30858868 2019
48
First Case of Esophagitis Dissecans Superficialis in an HIV Patient: A Case Report and Literature Review. 61
31355025 2019
49
Jejuno-jejunal intussusception in a post-lung transplant patient from a gastrojejunostomy tube: A case report. 61
30731299 2019
50
KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. 61
30998758 2019

Variations for Esophageal Disease

Expression for Esophageal Disease

Search GEO for disease gene expression data for Esophageal Disease.

Pathways for Esophageal Disease

Pathways related to Esophageal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 MIR483 MIR423 MIR223 MIR21 MIR200B MIR199A1
2 10.07 MIR199A1 MIR145

GO Terms for Esophageal Disease

Cellular components related to Esophageal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.44 MIR93 MIR486-1 MIR423 MIR338 MIR223 MIR21

Biological processes related to Esophageal Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.86 MIR338 MIR21 MIR200B MIR17
2 negative regulation of cardiac muscle hypertrophy GO:0010614 9.6 MIR21 MIR145
3 regulation of smooth muscle contraction GO:0006940 9.59 MIR145 MIR143
4 negative regulation of myotube differentiation GO:0010832 9.58 MIR200B CEACAM5
5 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.58 MIR199A1 MIR17
6 cellular sodium ion homeostasis GO:0006883 9.57 ATP4A ATP12A
7 negative regulation of angiogenesis GO:0016525 9.56 MIR21 MIR200B MIR145 MIR143
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.55 ATP4A ATP12A
9 sodium ion export across plasma membrane GO:0036376 9.54 ATP4A ATP12A
10 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.54 MIR21 MIR199A1 MIR145
11 cellular potassium ion homeostasis GO:0030007 9.52 ATP4A ATP12A
12 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.51 MIR199A1 MIR17
13 positive regulation of metalloendopeptidase activity GO:1904685 9.49 MIR21 MIR17
14 angiotensin-activated signaling pathway GO:0038166 9.48 MIR145 MIR143
15 gene silencing by miRNA GO:0035195 9.47 MIR93 MIR483 MIR423 MIR338 MIR223 MIR21
16 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.46 MIR21 MIR17
17 aorta smooth muscle tissue morphogenesis GO:0060414 9.43 MIR145 MIR143
18 regulation of phenotypic switching GO:1900239 9.4 MIR145 MIR143
19 miRNA mediated inhibition of translation GO:0035278 9.35 MIR483 MIR21 MIR200B MIR17 MIR145
20 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.32 MIR17 MIR143
21 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.16 MIR145 MIR143

Molecular functions related to Esophageal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR93 MIR483 MIR423 MIR338 MIR223 MIR21
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A

Sources for Esophageal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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