MCID: ESP008
MIFTS: 22

Esophageal Leukoplakia

Categories: Gastrointestinal diseases

Aliases & Classifications for Esophageal Leukoplakia

MalaCards integrated aliases for Esophageal Leukoplakia:

Name: Esophageal Leukoplakia 12 15
Leukoplakia of Esophagus 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9021
ICD9CM 34 530.83
NCIt 49 C3953
SNOMED-CT 67 89057003
UMLS 71 C0267095

Summaries for Esophageal Leukoplakia

MalaCards based summary : Esophageal Leukoplakia, also known as leukoplakia of esophagus, is related to gastroesophageal reflux and oral squamous cell carcinoma. An important gene associated with Esophageal Leukoplakia is CCND1 (Cyclin D1), and among its related pathways/superpathways are ErbB signaling pathway and Mitotic G1-G1/S phases.

Related Diseases for Esophageal Leukoplakia

Diseases related to Esophageal Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 gastroesophageal reflux 29.6 TP53 CCND1
2 oral squamous cell carcinoma 29.3 TP53 CCND1
3 leukoplakia 10.4
4 dysphagia 10.1
5 oral leukoplakia 10.0
6 pancreatic foamy gland adenocarcinoma 9.9 TP53 CCND1
7 esophagus verrucous carcinoma 9.9 TP53 CCND1
8 verrucous carcinoma 9.9 TP53 CCND1
9 mutagen sensitivity 9.9 TP53 CCND1
10 keratocystic odontogenic tumor 9.9 TP53 CCND1
11 bone squamous cell carcinoma 9.9 TP53 CCND1
12 nodular malignant melanoma 9.9 TP53 CCND1
13 laryngeal benign neoplasm 9.9 TP53 CCND1
14 skin papilloma 9.9 TP53 CCND1
15 papilloma 9.9 TP53 CCND1
16 cll/sll 9.9 TP53 CCND1
17 rhabdoid cancer 9.9 TP53 CCND1
18 respiratory system benign neoplasm 9.9 TP53 CCND1
19 inverted papilloma 9.9 TP53 CCND1
20 esophagus adenocarcinoma 9.9 TP53 CCND1
21 monoclonal gammopathy of uncertain significance 9.9 TP53 CCND1
22 uterine benign neoplasm 9.9 TP53 CCND1
23 vulva cancer 9.9 TP53 CCND1
24 reproductive organ benign neoplasm 9.9 TP53 CCND1
25 oropharynx cancer 9.9 TP53 CCND1
26 colonic benign neoplasm 9.9 TP53 CCND1
27 childhood medulloblastoma 9.9 TP53 CCND1
28 prolymphocytic leukemia 9.9 TP53 CCND1
29 lymphocytic leukemia 9.9 TP53 CCND1
30 oral cancer 9.9 TP53 CCND1
31 atypical teratoid rhabdoid tumor 9.9 TP53 CCND1
32 pre-malignant neoplasm 9.9 TP53 CCND1
33 endometrial adenocarcinoma 9.9 TP53 CCND1
34 basal cell nevus syndrome 9.8 TP53 CCND1
35 sporadic breast cancer 9.8 TP53 CCND1
36 skin squamous cell carcinoma 9.8 TP53 CCND1
37 estrogen-receptor positive breast cancer 9.8 TP53 CCND1
38 in situ carcinoma 9.8 TP53 CCND1
39 ovary adenocarcinoma 9.8 TP53 CCND1
40 breast carcinoma in situ 9.8 TP53 CCND1
41 laryngeal disease 9.8 TP53 CCND1
42 mature b-cell neoplasm 9.8 TP53 CCND1
43 intestinal benign neoplasm 9.8 TP53 CCND1
44 endometrial hyperplasia 9.8 TP53 CCND1
45 bile duct adenocarcinoma 9.8 TP53 CCND1
46 tongue disease 9.8 TP53 CCND1
47 penile cancer 9.8 TP53 CCND1
48 infratentorial cancer 9.8 TP53 CCND1
49 inflammatory myofibroblastic tumor 9.8 TP53 CCND1
50 gastrointestinal system benign neoplasm 9.8 TP53 CCND1

Graphical network of the top 20 diseases related to Esophageal Leukoplakia:



Diseases related to Esophageal Leukoplakia

Symptoms & Phenotypes for Esophageal Leukoplakia

Drugs & Therapeutics for Esophageal Leukoplakia

Search Clinical Trials , NIH Clinical Center for Esophageal Leukoplakia

Genetic Tests for Esophageal Leukoplakia

Anatomical Context for Esophageal Leukoplakia

Publications for Esophageal Leukoplakia

Articles related to Esophageal Leukoplakia:

# Title Authors PMID Year
1
The Significance of a Pale Area Via Flexible Spectral Imaging Color Enhancement in the Diagnosis of Esophageal Precancerous Lesions and Early-stage Squamous Cancer. 61
30829906 2019
2
Esophageal Leukoplakia. 61
31750380 2019
3
Widefield Endoscopic Mucosal Resection for Treatment of Proximal Esophageal Leukoplakia. 61
28804029 2018
4
Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges. 61
29034419 2018
5
Esophageal leukoplakia: a rare cause of white patches in esophagus with malignant potential. 61
25130786 2016
6
An Elderly Woman With an Uncommon Cause of Dysphagia. Esophageal Leukoplakia. 61
26226586 2015
7
Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients. 61
23765246 2014
8
[A case of the successful treatment of the esophageal leukoplakia with rabeprazole]. 61
12503273 2002
9
Esophageal leukoplakia. 61
3596196 1987
10
Esophageal leukoplakia: a rare entity. 61
642136 1978

Variations for Esophageal Leukoplakia

Expression for Esophageal Leukoplakia

Search GEO for disease gene expression data for Esophageal Leukoplakia.

Pathways for Esophageal Leukoplakia

Pathways related to Esophageal Leukoplakia according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 TP53 CCND1
2
Show member pathways
12.18 TP53 CCND1
3
Show member pathways
12.15 TP53 CCND1
4 12.15 TP53 CCND1
5 12.12 TP53 CCND1
6
Show member pathways
12.06 TP53 CCND1
7 12.04 TP53 CCND1
8
Show member pathways
12.02 TP53 CCND1
9
Show member pathways
12 TP53 CCND1
10 11.99 TP53 CCND1
11
Show member pathways
11.97 TP53 CCND1
12 11.96 TP53 CCND1
13 11.92 TP53 CCND1
14 11.91 TP53 CCND1
15
Show member pathways
11.87 TP53 CCND1
16
Show member pathways
11.84 TP53 CCND1
17
Show member pathways
11.84 TP53 CCND1
18 11.8 TP53 CCND1
19 11.78 TP53 CCND1
20 11.75 TP53 CCND1
21 11.68 TP53 CCND1
22
Show member pathways
11.65 TP53 CCND1
23 11.62 TP53 CCND1
24 11.6 TP53 CCND1
25 11.57 TP53 CCND1
26 11.55 TP53 CCND1
27 11.52 TP53 CCND1
28 11.42 TP53 CCND1
29 11.38 TP53 CCND1
30 11.27 TP53 CCND1
31 11.1 TP53 CCND1
32 11.03 TP53 CCND1
33 10.96 TP53 CCND1
34 10.85 TP53 CCND1
35 10.6 TP53 CCND1
36 10.13 TP53 CCND1

GO Terms for Esophageal Leukoplakia

Cellular components related to Esophageal Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear membrane GO:0031965 8.62 TP53 CCND1

Biological processes related to Esophageal Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.37 CCND1 TP53
2 cytokine-mediated signaling pathway GO:0019221 9.32 CCND1 TP53
3 regulation of cell cycle GO:0051726 9.26 CCND1 TP53
4 response to ethanol GO:0045471 9.16 TP53 CCND1
5 response to X-ray GO:0010165 8.96 TP53 CCND1
6 mitotic G1 DNA damage checkpoint GO:0031571 8.62 TP53 CCND1

Molecular functions related to Esophageal Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 8.62 TP53 CCND1

Sources for Esophageal Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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