MCID: ESP009
MIFTS: 21

Esophageal Neuroendocrine Tumor

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Esophageal Neuroendocrine Tumor

MalaCards integrated aliases for Esophageal Neuroendocrine Tumor:

Name: Esophageal Neuroendocrine Tumor 12 15 74
Neuroendocrine Tumor of Esophagus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5784
NCIt 51 C5821

Summaries for Esophageal Neuroendocrine Tumor

MalaCards based summary : Esophageal Neuroendocrine Tumor, also known as neuroendocrine tumor of esophagus, is related to neuroendocrine tumor and malignant skin fibrous histiocytoma. An important gene associated with Esophageal Neuroendocrine Tumor is CHGA (Chromogranin A), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include pineal.

Related Diseases for Esophageal Neuroendocrine Tumor

Diseases related to Esophageal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 29.5 CHGA NCAM1 SYP
2 malignant skin fibrous histiocytoma 10.0 CHGA NCAM1
3 malignant dermis tumor 10.0 CHGA NCAM1
4 lung combined type small cell carcinoma 10.0 NCAM1 SYP
5 cutaneous ganglioneuroma 9.9 NCAM1 SYP
6 extrahepatic bile duct adenocarcinoma 9.9 NCAM1 SYP
7 orbital cancer 9.9 NCAM1 SYP
8 hypoganglionosis 9.9 NCAM1 SYP
9 endometrial small cell carcinoma 9.9 NCAM1 SYP
10 pancreatic endocrine carcinoma 9.9 NCAM1 SYP
11 supratentorial primitive neuroectodermal tumor 9.9 NCAM1 SYP
12 mediastinal cancer 9.9 NCAM1 SYP
13 angiomyoma 9.9 NCAM1 SYP
14 cervical clear cell adenocarcinoma 9.9 NCAM1 SYP
15 cystadenoma 9.9 CHGA SYP
16 ureter small cell carcinoma 9.9 CHGA SYP
17 urinary bladder small cell neuroendocrine carcinoma 9.9 CHGA SYP
18 auditory system cancer 9.9 CHGA SYP
19 acinar cell cystadenocarcinoma 9.9 CHGA SYP
20 peritoneal serous adenocarcinoma 9.9 CHGA SYP
21 cellular ependymoma 9.9 CHGA SYP
22 primary hepatic neuroendocrine carcinoma 9.9 CHGA SYP
23 spermatocele 9.9 NCAM1 SYP
24 small cell carcinoma of the bladder 9.9 CHGA SYP
25 gastrointestinal neuroendocrine tumor 9.9 CHGA SYP
26 pulmonary large cell neuroendocrine carcinoma 9.9 CHGA SYP
27 atypical follicular adenoma 9.9 CHGA SYP
28 chordoid meningioma 9.9 CHGA SYP
29 olfactory groove meningioma 9.9 CHGA SYP
30 cauda equina neoplasm 9.9 CHGA SYP
31 olfactory nerve neoplasm 9.9 CHGA SYP
32 autonomic nervous system benign neoplasm 9.9 CHGA SYP
33 nodular ganglioneuroblastoma 9.9 CHGA SYP
34 pulmonary sclerosing hemangioma 9.9 CHGA SYP
35 sclerosing hemangioma 9.9 CHGA SYP
36 hemangioma 9.9 CHGA SYP
37 pineocytoma 9.9 CHGA SYP
38 pancreatoblastoma 9.9 CHGA SYP
39 carcinoid tumors, intestinal 9.9 CHGA SYP
40 respiratory system benign neoplasm 9.8 CHGA SYP
41 anterior cranial fossa meningioma 9.8 CHGA SYP
42 pulmonary blastoma 9.8 CHGA SYP
43 pleomorphic xanthoastrocytoma 9.8 CHGA SYP
44 tanycytic ependymoma 9.8 CHGA SYP
45 papillary ependymoma 9.8 CHGA SYP
46 non-functioning pancreatic endocrine tumor 9.8 CHGA SYP
47 adrenal rest tumor 9.8 NCAM1 SYP
48 central neurocytoma 9.8 CHGA SYP
49 binswanger's disease 9.8 CHGA SYP
50 carcinoid syndrome 9.8 CHGA SYP

Graphical network of the top 20 diseases related to Esophageal Neuroendocrine Tumor:



Diseases related to Esophageal Neuroendocrine Tumor

Symptoms & Phenotypes for Esophageal Neuroendocrine Tumor

Drugs & Therapeutics for Esophageal Neuroendocrine Tumor

Drugs for Esophageal Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
4 Antimetabolites, Antineoplastic Phase 2
5 Alkylating Agents Phase 2
6 Antimetabolites Phase 2
7 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Compare Capecitabine Combined With Dacarbazine(CAPDTIC) Versus Capecitabine Combined Temozolomide(CAPTEM) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Tumor Recruiting NCT03279601 Phase 2 Capecitabine, Dacarbazine;Capecitabine, Temozolomide

Search NIH Clinical Center for Esophageal Neuroendocrine Tumor

Genetic Tests for Esophageal Neuroendocrine Tumor

Anatomical Context for Esophageal Neuroendocrine Tumor

MalaCards organs/tissues related to Esophageal Neuroendocrine Tumor:

42
Pineal

Publications for Esophageal Neuroendocrine Tumor

Articles related to Esophageal Neuroendocrine Tumor:

# Title Authors Year
1
Esophageal neuroendocrine tumor with initial presentation as painless forehead and neck masses: A case report. ( 29390385 )
2017
2
Esophageal neuroendocrine tumor metastatic to the pineal region. ( 24531830 )
2014

Variations for Esophageal Neuroendocrine Tumor

Expression for Esophageal Neuroendocrine Tumor

Search GEO for disease gene expression data for Esophageal Neuroendocrine Tumor.

Pathways for Esophageal Neuroendocrine Tumor

Pathways related to Esophageal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 NCAM1 SYP

GO Terms for Esophageal Neuroendocrine Tumor

Sources for Esophageal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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