MCID: ESP009
MIFTS: 21

Esophageal Neuroendocrine Tumor

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Esophageal Neuroendocrine Tumor

MalaCards integrated aliases for Esophageal Neuroendocrine Tumor:

Name: Esophageal Neuroendocrine Tumor 12 15 73
Neuroendocrine Tumor of Esophagus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5784
NCIt 50 C5821

Summaries for Esophageal Neuroendocrine Tumor

MalaCards based summary : Esophageal Neuroendocrine Tumor, also known as neuroendocrine tumor of esophagus, is related to neuroendocrine tumor and malignant skin fibrous histiocytoma. An important gene associated with Esophageal Neuroendocrine Tumor is CHGA (Chromogranin A), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capecitabine and Dacarbazine have been mentioned in the context of this disorder. Affiliated tissues include pineal.

Related Diseases for Esophageal Neuroendocrine Tumor

Diseases related to Esophageal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 28.6 CHGA NCAM1 SYP
2 malignant skin fibrous histiocytoma 10.0 CHGA NCAM1
3 malignant dermis tumor 10.0 CHGA NCAM1
4 lung combined type small cell carcinoma 9.9 NCAM1 SYP
5 sensory organ benign neoplasm 9.9 NCAM1 SYP
6 cutaneous ganglioneuroma 9.9 NCAM1 SYP
7 extrahepatic bile duct adenocarcinoma 9.9 NCAM1 SYP
8 orbital cancer 9.9 NCAM1 SYP
9 esophagitis 9.9
10 hypoganglionosis 9.9 NCAM1 SYP
11 pancreatic endocrine carcinoma 9.9 NCAM1 SYP
12 supratentorial primitive neuroectodermal tumor 9.9 NCAM1 SYP
13 endometrial small cell carcinoma 9.9 NCAM1 SYP
14 mediastinal cancer 9.9 NCAM1 SYP
15 angiomyoma 9.9 NCAM1 SYP
16 cervical clear cell adenocarcinoma 9.8 NCAM1 SYP
17 spermatocele 9.8 NCAM1 SYP
18 ureter small cell carcinoma 9.8 CHGA SYP
19 urinary bladder small cell neuroendocrine carcinoma 9.8 CHGA SYP
20 auditory system cancer 9.8 CHGA SYP
21 adenoma of the pancreas 9.8 CHGA SYP
22 acinar cell cystadenocarcinoma 9.8 CHGA SYP
23 peritoneal serous adenocarcinoma 9.8 CHGA SYP
24 cellular ependymoma 9.8 CHGA SYP
25 primary hepatic neuroendocrine carcinoma 9.8 CHGA SYP
26 small cell carcinoma of the bladder 9.8 CHGA SYP
27 gastrointestinal neuroendocrine tumor 9.8 CHGA SYP
28 pulmonary large cell neuroendocrine carcinoma 9.8 CHGA SYP
29 atypical follicular adenoma 9.8 CHGA SYP
30 chordoid meningioma 9.8 CHGA SYP
31 olfactory nerve neoplasm 9.8 CHGA SYP
32 cauda equina neoplasm 9.8 CHGA SYP
33 nodular ganglioneuroblastoma 9.8 CHGA SYP
34 pulmonary sclerosing hemangioma 9.8 CHGA SYP
35 pineocytoma 9.7 CHGA SYP
36 respiratory system benign neoplasm 9.7 CHGA SYP
37 pancreatoblastoma 9.7 CHGA SYP
38 carcinoid tumors, intestinal 9.7 CHGA SYP
39 adrenal rest tumor 9.7 NCAM1 SYP
40 pulmonary blastoma 9.7 CHGA SYP
41 ureter, cancer of 9.7 CHGA SYP
42 tanycytic ependymoma 9.7 CHGA SYP
43 papillary ependymoma 9.7 CHGA SYP
44 non-functioning pancreatic endocrine tumor 9.7 CHGA SYP
45 pleomorphic xanthoastrocytoma 9.7 CHGA SYP
46 sclerosing hemangioma 9.7 CHGA SYP
47 central neurocytoma 9.7 CHGA SYP
48 pancreatic cystadenocarcinoma 9.7 CHGA SYP
49 binswanger's disease 9.7 CHGA SYP
50 carcinoid syndrome 9.7 CHGA SYP

Graphical network of the top 20 diseases related to Esophageal Neuroendocrine Tumor:



Diseases related to Esophageal Neuroendocrine Tumor

Symptoms & Phenotypes for Esophageal Neuroendocrine Tumor

Drugs & Therapeutics for Esophageal Neuroendocrine Tumor

Drugs for Esophageal Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
2
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
3
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
4 Alkylating Agents Phase 2
5 Antimetabolites Phase 2
6 Antimetabolites, Antineoplastic Phase 2
7 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Compare Capecitabine Combined With Dacarbazine(CAPDTIC) Versus Capecitabine Combined Temozolomide(CAPTEM) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Tumor Recruiting NCT03279601 Phase 2 Capecitabine, Dacarbazine;Capecitabine, Temozolomide

Search NIH Clinical Center for Esophageal Neuroendocrine Tumor

Genetic Tests for Esophageal Neuroendocrine Tumor

Anatomical Context for Esophageal Neuroendocrine Tumor

MalaCards organs/tissues related to Esophageal Neuroendocrine Tumor:

41
Pineal

Publications for Esophageal Neuroendocrine Tumor

Articles related to Esophageal Neuroendocrine Tumor:

# Title Authors Year
1
Esophageal neuroendocrine tumor with initial presentation as painless forehead and neck masses: A case report. ( 29390385 )
2017
2
An esophageal neuroendocrine tumor metastatic to the pineal region. ( 24531830 )
2014

Variations for Esophageal Neuroendocrine Tumor

Expression for Esophageal Neuroendocrine Tumor

Search GEO for disease gene expression data for Esophageal Neuroendocrine Tumor.

Pathways for Esophageal Neuroendocrine Tumor

Pathways related to Esophageal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 NCAM1 SYP

GO Terms for Esophageal Neuroendocrine Tumor

Sources for Esophageal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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