MCID: ESP009
MIFTS: 25

Esophageal Neuroendocrine Tumor

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Esophageal Neuroendocrine Tumor

MalaCards integrated aliases for Esophageal Neuroendocrine Tumor:

Name: Esophageal Neuroendocrine Tumor 12 15 70
Neuroendocrine Tumour of Oesophagus 12
Neuroendocrine Tumor of Esophagus 12
Esophageal Neuroendocrine Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5784
NCIt 50 C5821
UMLS 70 C1333462 C2987260

Summaries for Esophageal Neuroendocrine Tumor

MalaCards based summary : Esophageal Neuroendocrine Tumor, also known as neuroendocrine tumour of oesophagus, is related to neuroendocrine tumor and neuroendocrine carcinoma. An important gene associated with Esophageal Neuroendocrine Tumor is SYP (Synaptophysin), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cell adhesion_Cell-matrix glycoconjugates. The drugs Capecitabine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and pineal.

Related Diseases for Esophageal Neuroendocrine Tumor

Diseases related to Esophageal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 30.5 SYP NCAM1 CHGA
2 neuroendocrine carcinoma 29.4 SYP NCAM1 MUC1 CHGA
3 olfactory neuroblastoma 10.2 SYP CHGA
4 primary hepatic neuroendocrine carcinoma 10.2 SYP CHGA
5 auditory system cancer 10.2 SYP CHGA
6 acinar cell cystadenocarcinoma 10.2 SYP CHGA
7 cauda equina neoplasm 10.2 SYP CHGA
8 gastrointestinal neuroendocrine benign tumor 10.2 SYP CHGA
9 ampulla of vater benign neoplasm 10.2 SYP CHGA
10 appendix carcinoid tumor 10.2 SYP CHGA
11 carotid body cancer 10.2 SYP CHGA
12 vaginal tubulovillous adenoma 10.2 SYP CHGA
13 mixed ductal-endocrine carcinoma 10.2 SYP CHGA
14 duodenal benign neoplasm 10.2 SYP CHGA
15 gastric neuroendocrine neoplasm 10.2 SYP CHGA
16 appendix adenocarcinoma 10.2 SYP CHGA
17 gastric hemangioma 10.2 SYP CHGA
18 pineocytoma 10.2 SYP CHGA
19 pancreatic gastrinoma 10.2 SYP CHGA
20 cervix small cell carcinoma 10.2 SYP CHGA
21 adrenal neuroblastoma 10.2 SYP CHGA
22 gastrointestinal neuroendocrine tumor 10.2 SYP CHGA
23 carcinoid tumors, intestinal 10.2 SYP CHGA
24 vaginal adenoma 10.2 SYP CHGA
25 vaginal benign neoplasm 10.2 SYP CHGA
26 carcinoid syndrome 10.2 SYP CHGA
27 binswanger's disease 10.2 SYP CHGA
28 pancreatic acinar cell adenocarcinoma 10.2 SYP CHGA
29 extra-adrenal pheochromocytoma 10.2 SYP CHGA
30 small intestine benign neoplasm 10.2 SYP CHGA
31 peritoneal serous adenocarcinoma 10.2 SYP CHGA
32 meckel diverticulum 10.2 SYP CHGA
33 anal neuroendocrine tumor 10.2 SYP NCAM1
34 granulosa cell tumor of the ovary 10.2 SYP CHGA
35 lung combined type small cell carcinoma 10.2 SYP NCAM1
36 sinonasal undifferentiated carcinoma 10.2 SYP MUC1
37 papillary tumor of the pineal region 10.2 SYP MUC1
38 bile duct mucinous adenocarcinoma 10.2 SYP MUC1
39 hypoganglionosis 10.2 SYP NCAM1
40 glomangiosarcoma 10.1 SYP NCAM1
41 adrenal medulla cancer 10.1 SYP CHGA
42 cerebellopontine angle primitive neuroectodermal tumor 10.1 SYP NCAM1
43 horseshoe kidney 10.1 SYP CHGA
44 pulmonary sclerosing hemangioma 10.1 SYP CHGA
45 autonomic nervous system benign neoplasm 10.1 SYP CHGA
46 peripheral nervous system benign neoplasm 10.1 SYP CHGA
47 orbital cancer 10.1 SYP NCAM1
48 prostate stromal sarcoma 10.1 SYP NCAM1
49 extraosseous ewing sarcoma 10.1 SYP NCAM1
50 cecal disease 10.1 SYP CHGA

Graphical network of the top 20 diseases related to Esophageal Neuroendocrine Tumor:



Diseases related to Esophageal Neuroendocrine Tumor

Symptoms & Phenotypes for Esophageal Neuroendocrine Tumor

Drugs & Therapeutics for Esophageal Neuroendocrine Tumor

Drugs for Esophageal Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166 2942
4 Alkylating Agents Phase 2
5 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled Phase II Study to Compare Capecitabine Combined With Dacarbazine(CAPDTIC) Versus Capecitabine Combined Temozolomide(CAPTEM) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Tumor Unknown status NCT03279601 Phase 2 Capecitabine, Dacarbazine;Capecitabine, Temozolomide

Search NIH Clinical Center for Esophageal Neuroendocrine Tumor

Genetic Tests for Esophageal Neuroendocrine Tumor

Anatomical Context for Esophageal Neuroendocrine Tumor

MalaCards organs/tissues related to Esophageal Neuroendocrine Tumor:

40
Lung, Breast, Pineal, Thymus, Prostate, Appendix, Small Intestine

Publications for Esophageal Neuroendocrine Tumor

Articles related to Esophageal Neuroendocrine Tumor:

# Title Authors PMID Year
1
A Case of Pedunculated Esophageal Neuroendocrine Tumor G1. 61
33662595 2021
2
68Ga-DOTATATE PET/CT Findings of Cervical Esophageal Neuroendocrine Tumor. 61
33630804 2021
3
Clinicopathological features and outcome of esophageal neuroendocrine tumor: A retrospective multicenter survey by the digestive endoscopy society of Taiwan. 61
32600867 2021
4
An esophageal neuroendocrine tumor in a Barrett's esophagus successfully treated with endoscopic resection. 61
33054288 2020
5
Reply to the Editor: "Is There a Role of Surgery in Treating Localized Esophageal Neuroendocrine Tumor?" 61
31828689 2020
6
Is There a Role for Surgery in Treating Localized Esophageal Neuroendocrine Tumor? 61
31828688 2020
7
Esophageal neuroendocrine tumor with initial presentation as painless forehead and neck masses: A case report. 61
29390385 2017
8
Progress in the treatment of esophageal neuroendocrine carcinoma. 61
28653897 2017
9
Esophageal neuroendocrine tumor metastatic to the pineal region. 61
24531830 2014

Variations for Esophageal Neuroendocrine Tumor

Expression for Esophageal Neuroendocrine Tumor

Search GEO for disease gene expression data for Esophageal Neuroendocrine Tumor.

Pathways for Esophageal Neuroendocrine Tumor

Pathways related to Esophageal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 SYP NCAM1
2 10.21 NCAM1 MUC1

GO Terms for Esophageal Neuroendocrine Tumor

Sources for Esophageal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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