MCID: ESP024
MIFTS: 60

Esophagitis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Esophagitis

MalaCards integrated aliases for Esophagitis:

Name: Esophagitis 12 54 44 15 71
Acute Esophagitis 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11963
ICD9CM 34 530.1
MeSH 44 D004941
NCIt 50 C9224
SNOMED-CT 67 155673008
ICD10 32 K20
UMLS 71 C0014868 C0149882

Summaries for Esophagitis

MalaCards based summary : Esophagitis, also known as acute esophagitis, is related to peptic esophagitis and hernia, hiatus, and has symptoms including pain in esophagus (finding) An important gene associated with Esophagitis is CCL26 (C-C Motif Chemokine Ligand 26), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Rabeprazole and Trimebutine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Esophagitis, also spelled oesophagitis, is a disease characterized by inflammation of the esophagus. The... more...

Related Diseases for Esophagitis

Diseases in the Esophagitis family:

Bacterial Esophagitis Viral Esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 814)
# Related Disease Score Top Affiliating Genes
1 peptic esophagitis 32.6 TNF IL1B HRH2 GAST CYP2C19 CXCL8
2 hernia, hiatus 31.8 HRH2 GAST CYP2C19
3 esophagitis, eosinophilic, 1 31.5 TSLP STAT6 IL5 IL4 IL33 IL13
4 helicobacter pylori infection 31.3 TNF IL1B CYP2C19 CXCL8
5 ige responsiveness, atopic 31.3 IL5 IL4 IL13
6 gastritis 31.3 TNF IL1B HRH2 GAST CYP2C19 CXCL8
7 eosinophilic gastroenteritis 31.2 TSLP PRG2 IL5 IL4 IL33 CCL26
8 gastroesophageal reflux 31.2 TNF IL5 IL4 IL1B HRH2 GAST
9 cytokine deficiency 31.1 IL5 IL13
10 duodenal ulcer 31.0 TNF IL1B HRH2 GAST CYP2C19 CXCL8
11 peptic ulcer disease 31.0 TNF IL1B HRH2 GAST CYP2C19 CXCL8
12 candidiasis 31.0 TNF IL4 IL1B CXCL8
13 dyskinesia of esophagus 30.9 IL13 HRH2 CCL26 CAPN14
14 atrophic gastritis 30.9 TNF IL1B GAST CXCL8
15 laryngitis 30.8 TNF IL1B HRH2
16 crohn's colitis 30.8 TNF IL1B CXCL8
17 pharyngitis 30.7 TNF IL1B CXCL8
18 gastric ulcer 30.7 TNF IL1B HRH2 GAST CYP2C19 CXCL8
19 food allergy 30.7 TNF STAT6 IL5 IL4 IL13 FLG
20 crohn's disease 30.6 TNF IL4 IL1B IL13 CXCL8
21 hypereosinophilic syndrome 30.6 PRG2 IL5 IL4 IL13 CXCL8 CCR3
22 gastroduodenitis 30.5 GAST CCL26
23 exanthem 30.5 TNF IL1B CXCL8
24 systemic scleroderma 30.5 TNF IL4 IL13 HRH2 GAST
25 celiac disease 1 30.4 TNF IL5 IL4 IL1B IL13 GAST
26 stomatitis 30.4 TNF IL4 IL1B CXCL8
27 pollen allergy 30.4 PRG2 IL5 IL13
28 allergic rhinitis 30.3 IL5 IL4 IL13 CXCL8 CCR3 CCL24
29 irritable bowel syndrome 30.3 TNF IL4 IL1B CXCL8
30 neutropenia 30.3 TNF IL4 IL1B CXCL8
31 bronchopneumonia 30.2 TNF IL1B CXCL8
32 bronchiectasis 30.2 TNF IL1B CXCL8
33 milk allergy 30.2 TNF STAT6 IL5 IL4 IL13
34 pemphigoid 30.2 TNF IL5 IL4 IL1B IL13 CCL11
35 pemphigus 30.2 TNF IL4 DSG1
36 pericarditis 30.2 TNF IL1B CXCL8
37 ulcerative colitis 30.1 TNF IL4 IL1B IL13 CXCL8 CCR3
38 acne 30.1 TNF IL1B FLG CXCL8
39 chronic spontaneous urticaria 30.1 TSLP TNF IL33 CXCL8
40 familial mediterranean fever 30.1 TNF IL1B CXCL8
41 peanut allergy 30.1 IL5 IL4 IL13 FLG
42 thyroiditis 30.0 TNF IL4 IL1B
43 rhinitis 30.0 TSLP TNF PRG2 IL5 IL4 IL33
44 actinomycosis 30.0 TNF IL4 IL1B
45 sleep apnea 30.0 TNF IL1B CXCL8
46 respiratory allergy 30.0 IL5 IL4 IL13
47 colitis 30.0 TNF IL4 IL1B IL13 CXCL8 CCR3
48 tracheitis 30.0 TNF IL1B CXCL8
49 anthracosis 30.0 TNF IL1B CXCL8
50 immune deficiency disease 30.0 TNF IL4 IL1B IL13 CCR3

Comorbidity relations with Esophagitis via Phenotypic Disease Network (PDN): (show top 50) (show all 109)


Active Peptic Ulcer Disease Acute Cystitis
Acute Maxillary Sinusitis Acute Pancreatitis
Alcoholic Gastritis Allergic Rhinitis
Angina Pectoris Anxiety
Aortic Valve Disease 1 Atrophic Gastritis
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Bronchopneumonia Cerebrovascular Disease
Cholecystitis Cholestasis
Chronic Intestinal Vascular Insufficiency Chronic Maxillary Sinusitis
Chronic Pulmonary Heart Disease Chronic Rhinitis
Chylomicron Retention Disease Conn's Syndrome
Conversion Disorder Cystitis
Deficiency Anemia Dependent Personality Disorder
Dermatomycosis Diabetic Polyneuropathy
Duodenitis Dyskinesia of Esophagus
Dysthymic Disorder Esophageal Cancer
Esophageal Candidiasis Esophageal Disease
Esophageal Varix First-Degree Atrioventricular Block
Gallbladder Disease Gastrin Secretion Abnormality
Gastritis, Familial Giant Hypertrophic Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis
Heart Disease Hepatitis
Hyperlipoproteinemia, Type Iv Hyperlipoproteinemia, Type V
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to Esophagitis

Symptoms & Phenotypes for Esophagitis

UMLS symptoms related to Esophagitis:


pain in esophagus (finding)

MGI Mouse Phenotypes related to Esophagitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCL11 CCL24 CCR3 IL13 IL1B IL33
2 immune system MP:0005387 9.97 CCL11 CCL24 CCR3 GAST IL13 IL1B
3 digestive/alimentary MP:0005381 9.92 GAST HRH2 IL13 IL33 IL4 IL5
4 integument MP:0010771 9.61 DSG1 IL13 IL1B IL33 IL4 PRG2
5 respiratory system MP:0005388 9.36 CCL11 CCL24 CCR3 IL13 IL33 IL4

Drugs & Therapeutics for Esophagitis

Drugs for Esophagitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 585)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
2
Trimebutine Approved Phase 4 39133-31-8
3
Pravastatin Approved Phase 4 81093-37-0 54687
4
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
5
Clarithromycin Approved Phase 4 81103-11-9 84029
6
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
7
Pantoprazole Approved Phase 4 102625-70-7 4679
8
Somatostatin Approved, Investigational Phase 4 51110-01-1, 38916-34-6 53481605
9
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
10
Ethanolamine oleate Approved Phase 4 2272-11-9
11
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
12
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
13
Rebamipide Approved, Investigational Phase 4 90098-04-7
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
16
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
17
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
18
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
19
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
20
Phenylephrine Approved Phase 4 59-42-7 6041
21
Calcium polycarbophil Approved Phase 4 126040-58-2
22
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
23
Norepinephrine Approved Phase 4 51-41-2 439260
24
Dobutamine Approved Phase 4 34368-04-2 36811
25
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
26
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
27
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
28
Codeine Approved, Illicit Phase 4 76-57-3 5284371
29
Citalopram Approved Phase 4 59729-33-8 2771
30
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
31 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
32
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
33
Propranolol Approved, Investigational Phase 4 525-66-6 4946
34
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
35 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
36
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
37
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
38
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
39
Zinc Approved, Investigational Phase 4 7440-66-6 32051
40
Prucalopride Approved Phase 4 179474-81-8
41
Edrophonium Approved Phase 4 312-48-1, 116-38-1 3202
42
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
43
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
44
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
45
Docetaxel Approved, Investigational Phase 4 114977-28-5 148124
46
Nedaplatin Approved, Investigational Phase 4 95734-82-0
47
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
48
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
49
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
50 Mosapride Investigational Phase 4 112885-41-3

Interventional clinical trials:

(show top 50) (show all 2233)
# Name Status NCT ID Phase Drugs
1 Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity Unknown status NCT02140073 Phase 4 omeprazole+domperidone SR;omeprazole
2 Different Lugol's Solution Concentration for Image Quality of Early Esophageal Squamous Neoplasia in Chromoendoscopy With Iodine Staining Unknown status NCT03180970 Phase 4 1.2% Lugol's solution;1.0% Lugol's solution;0.8% Lugol's solution;0.6% Lugol's solution;0.4% Lugol's solution
3 Cryoballoon Pulmonary Vein Isolation and Associated Esophageal Effects Unknown status NCT02998866 Phase 4
4 Comparing Dexlansoprazole With Double-dose Lansoprazole to Achieve Sustained Symptomatic Response in Overweight and Obesity Patients With Reflux Esophagitis in Los Angeles Grades A & B Unknown status NCT02759393 Phase 4 Dexlansoprazole;Lansoprazole
5 The Clinical Efficacy and Safety of Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Unknown status NCT02986685 Phase 4 Trimebutine Maleate;rabeprazole
6 Banding Ligation Plus Propranolol Versus Banding Ligation to Prevent Rebleeding of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
7 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
8 A Multi-Center Randomized Trial of Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair Unknown status NCT03730454 Phase 4
9 Effect of Magnesium Alginate on Gastroesophageal Reflux in Infants. Unknown status NCT02806453 Phase 4
10 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
11 Randomized Controlled Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
12 Intrathoracic Esophagogastric Anastomosis After Robot Assisted Minimally Invasive Esophagectomy Using STRATAFIX Unknown status NCT02609425 Phase 4
13 Postoperative Pain Management After Minimally Invasive Esophagectomy Unknown status NCT02042313 Phase 4
14 Clinical and Medico-economic Evaluation of Radiofrequency Ablation Versus Oesophagectomy in the Treatment of High Grade Dysplasia in Barrett's Oesophagus Unknown status NCT02558504 Phase 4
15 A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Sodium Glycididazole in Concurrent Radiochemotherapy for the Treatment of Thoracic Esophageal Squamous Carcinoma Unknown status NCT00642239 Phase 4 placebo;Sodium Glycididazole
16 Randomized Double Blinded Trial to Investigate Effects of an Enteral Nutritional Supplement Enriched With Eicosapentaenoic Acid on Body Composition,Complications,Stress Response,Immune Function & Quality of Life in After Esophagectomy Unknown status NCT00790140 Phase 4
17 Prevention of Esophageal Variceal Rebleeding Unknown status NCT00863837 Phase 4 terlipressin (vasoconstrictor);pantoloc (proton pump inhibitor)
18 Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Comparing Carvedilol and Endoscopic Therapy: A Multicenter Randomized Controlled Trial Unknown status NCT02695732 Phase 4 Carvedilol
19 Endoesophageal Cryotherapy: A New Technique For Ablating Barrett's Esophagus And Early Stage Esophageal Cancer Unknown status NCT00628784 Phase 4
20 Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication Unknown status NCT02934152 Phase 4 H pylori eradication
21 A Randomized, Controlled Trial of Ligation Plus Vasoconstrictor vs.Ligation Plus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
22 The Rates of Complete Symptom Relief,Prevetion of Symptom Relapse and Maintenance of Esophagitis Healing for 4-week Versus 8-week Esomeprazole Therapy Among Los Angeles Grades A and B Erosive Esophagitis Completed NCT01874535 Phase 4 Esomeprazole 40 mg
23 A Multi-Center, Prospective, Randomized (RCT) Study Comparing WallFlex® Esophageal Fully Covered (FC) Metal Stent to Bougie Dilation for the Treatment of Refractory Anastomotic Esophageal Strictures Completed NCT01699542 Phase 4
24 A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis. Completed NCT00641602 Phase 4 Esomeprazole;Lansoprazole
25 Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Out-patients Undergoing Diagnostic Trans-esophageal Echocardiography: A Randomized Controlled Trial Completed NCT02867930 Phase 4 Dexmedetomidine;Ketofol(ketamine+propofol)
26 A Comparison of Crystalloids vs. Colloids for Intraoperative Goal-directed Fluid Management Completed NCT00517127 Phase 4 Lactated Ringer's Solution;Hydroxyethylstarch 6% 130/0.4
27 An 8-week, Open Label, Multicentre Study to Assess the Efficacy of Esomeprazole 20 mg Once Daily in Subjects With Continuing Symptoms of Heartburn Following Treatment With a Previous Rabeprazole Completed NCT01397084 Phase 4 esomeprazole 20 mg
28 An 8-weeks, Multicenter, Single Arm, Non-comparative, Phase 4 Clinical Trial to Assess the Efficacy and Safety of Newrabell® Tab. at 10mg b.i.d in Patients With Refractory Reflux Esophagitis(rGERD) to the Prior Standard PPIs Regimen Completed NCT01860482 Phase 4 Newrabell® Tablet 10mg
29 A Multicenter, Double-Blind, Randomized Trial of the Relationship of Intragastric Acid Control and Healing Status of Moderate and Severe Erosive Esophagitis After Treatment With Esomeprazole Magnesium (NEXIUM®) 10 mg and 40 mg Once Daily Completed NCT00206180 Phase 4 esomeprazole magnesium (oral medication)
30 Impact of Timing on the Efficacy of Omeprazole/Sodium Bicarbonate Zegerid 40 mg in Healing Reflux Esophagitis Completed NCT00693225 Phase 4 Omeprazole/sodium bicarbonate
31 A Multicenter, Randomized, Double-blinded, Placebo-controlled Pilot Study to Evaluate the Efficacy and Safety of Rebamipide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis (REPAIR) Completed NCT02755753 Phase 4 Lansoprazole;Rebamipide;Rebamipide-placebo
32 Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis Completed NCT02019758 Phase 4 Oral Viscous Budesonide;Fluticasone MDI;Placebo slurry;Placebo inhaler
33 COMPARISON OF TREATMENT FOR PEDIATRIC EOSINOPHILIC ESOPHAGITIS: A RANDOMIZED CLINICAL TRIAL (DIETETIC Versus TOPICAL STEROIDS) Completed NCT01846962 Phase 4 Budesonide;Fluticasone;Oral Viscous Budesonide (OVB)
34 Effect of Rabeprazole and Lansoprazole on Reflux Esophagitis in Relation to CYP2C19 Genotype Status: A Prospective, Randomized, Multicenter Study Completed NCT01008696 Phase 4 Rabeprazole;Lansoprazole
35 A Randomized, Double-blind, Placebo-controlled Study of the Use of Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Completed NCT02371941 Phase 4 oral cromolyn sodium;Placebo
36 Laparoscopic Nissen Fundoplication Combined With Posterior Gastropexy in Surgical Treatment of Gastroesophageal Reflux Disease Completed NCT00872755 Phase 4
37 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation (VISTAEXE) Completed NCT03116841 Phase 4 Vonoprazan
38 Open-Label Single-Arm Phase IV Study of Pemetrexed in Taiwanese Patients With Advanced Non-Small Cell Lung Cancer Who Have Had Prior Chemotherapy Completed NCT00380718 Phase 4 pemetrexed
39 Role of Bronchoalveolar Lavage Pepsin Assay in Wheezy Infants Completed NCT02685436 Phase 4 Omeprazole and domperidone
40 A Pilot Study of Efficacy and Safety of Continuous Intravenous Infusion of Pantoprazole in the Treatment of Severe Erosive Esophagitis Completed NCT00133770 Phase 4 pantoprazole
41 Can Opioid Induced Effects on Esophageal Motility and Lower Esophageal Sphincter be Counteracted by a Dopamine Receptor Antagonist? Completed NCT01191645 Phase 4 naloxone;remifentanil;Sodium Chloride;metoclopramide
42 Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Comparison of the Remission Rates of Once Daily Treatment With Esomeprazole 20mg and Lansoprazole 15mg for 6 Months in Patients Whose EE Has Been Healed. Completed NCT00644735 Phase 4 Esomeprazole;Lansoprazole
43 An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD) to Investigate the Relationship Between the Presence of Erosive Esophagitis (EE) at Baseline and Heartburn Resolution After 4 Weeks of Treatment Completed NCT00242736 Phase 4 Esomeprazole
44 A Phase III, Multicentre, Randomized, Double-blind Parallel-group Study to Evaluate the Safety and Clinical Outcome of Once Daily Esomeprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Pediatric Patients 1 to 11 Years of Age, Inclusive. Completed NCT00228527 Phase 4 Esomeprazole (Nexium)
45 Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?: A Randomized Controlled Trial Completed NCT01093755 Phase 4 dexlansoprazole;Omeprazole
46 A Randomized, Controlled, Multicentric Trial Comparing Endoscopic Band Ligation Versus Ransjugular Intrahepatic Portosystemic Stent Shunt in Cirrhotic Patients With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
47 Appropriate Time Interval for Repeat Sessions of Endoscopic Ligation for the Eradication of Esophageal Varices Completed NCT01291277 Phase 4
48 Intraoperative Goal Directed Fluid Therapy in Lean and Obese Patients Completed NCT00860704 Phase 4 fluidotherapy with ringer-lactate
49 A Clinical Trial of the Vessel Sealing System (LigaSure) in Azygoportal Disconnection and Splenectomy in Patients With Portal Hypertension Completed NCT00965744 Phase 4
50 An Open Label, Multicentre Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI) Completed NCT00734097 Phase 4 Esomeprazole 40 mg

Search NIH Clinical Center for Esophagitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Esomeprazole
Esomeprazole magnesium
esomeprazole sodium
Esomeprazole Strontium
lansoprazole
Omeprazole
Omeprazole 2 MG/ML Oral Suspension
Omeprazole magnesium
pantoprazole
Pantoprazole sodium
Sucralfate

Cochrane evidence based reviews: esophagitis

Genetic Tests for Esophagitis

Anatomical Context for Esophagitis

MalaCards organs/tissues related to Esophagitis:

40
Lymph Node, Liver, Lung, Smooth Muscle, T Cells, Skin, Colon

Publications for Esophagitis

Articles related to Esophagitis:

(show top 50) (show all 13384)
# Title Authors PMID Year
1
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. 61 54
20208004 2010
2
Regulation of CDX2 expression in esophageal adenocarcinoma. 61 54
19415720 2009
3
Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. 54 61
18844613 2008
4
[Eosinophilic esophagitis : a cause of dysphagia]. 61 54
18214405 2008
5
IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. 54 61
18073124 2007
6
Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. 54 61
17900656 2007
7
Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. 61 54
17473952 2007
8
Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis. 61 54
17059896 2006
9
CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation. 61 54
16868800 2006
10
Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury. 54 61
16306134 2006
11
What is the best way to manage GERD symptoms in the elderly? 61 54
16510061 2006
12
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. 61 54
16453027 2006
13
Lower prevalence of Helicobacter pylori infection with vacAs1a, cagA-positive, and babA2-positive genotype in erosive reflux esophagitis disease. 54 61
16302983 2005
14
Eosinophilic esophagitis. 54 61
16282772 2005
15
Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus. 54 61
15884106 2005
16
The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation. 61 54
14992433 2004
17
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. 61 54
14724818 2003
18
Regulation of Na/H exchanger-1 in gastroesophageal reflux disease: possible interaction of histamine receptor. 54 61
14561010 2003
19
Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. 61 54
12560917 2003
20
Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis. 54 61
12392390 2002
21
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. 61 54
11474496 2001
22
The association between CagA status and the development of esophagitis after the eradication of Helicobacter pylori. 61 54
11403754 2001
23
Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. 54 61
11121210 2001
24
Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture. 61 54
10900424 2000
25
Gastroesophageal reflux disease: pathophysiology and pharmacology overview. 54 61
10826019 2000
26
Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene. 54 61
10492161 1999
27
Duodenal ulcer and gastroesophageal reflux disease today: long-term therapy--a sideways glance. 54 61
9165690 1996
28
Esophageal Fibrosis in Eosinophilic Gastrointestinal Diseases. 61
33230074 2021
29
Sudden Appearance of Widespread Esophageal Squamous Papilloma With Reflux Esophagitis. 61
32036041 2021
30
Dietary Management of Eosinophilic Esophagitis: Man Versus Food or Food Versus Man? 61
33518169 2021
31
Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis. 61
32205221 2021
32
Eosinophilic esophagitis may persist after discontinuation of oral immunotherapy. 61
33340664 2021
33
Comorbid Diagnosis of Eosinophilic Esophagitis and Inflammatory Bowel Disease in the Pediatric Population. 61
33230079 2021
34
Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. 61
32068153 2021
35
Phase II clinical trial with metronomic oral vinorelbine and tri-weekly cisplatin as induction therapy, subsequently concomitant with radiotherapy (RT) in patients with locally advanced, unresectable, non-small cell lung cancer (NSCLC). Analysis of survival and value of ctDNA for patient selection. 61
33453470 2021
36
Dabigatran-induced esophagitis masking esophageal cancer. 61
32505570 2021
37
Simultaneous integrated boost for mediastinal lymph node recurrence after radical surgery for esophageal cancer: Interim results from a phase I/II prospective study. 61
33605068 2021
38
Treatment-related complications in patients with esophageal cancer: A systematic review and network meta-analysis. 61
32209308 2021
39
Stimulated saliva secretion is reduced in proton pump inhibitor-resistant severe reflux esophagitis patients. 61
33590389 2021
40
Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case-control study in Albania. 61
33593300 2021
41
Mucosal Deposition of Ferrous Sulfate Leading to Esophagitis Dissecans Superficialis. 61
32958164 2021
42
Machine learning approach for differentiating cytomegalovirus esophagitis from herpes simplex virus esophagitis. 61
33574361 2021
43
Effects of glutamine for prevention of radiation-induced esophagitis: a double-blind placebo-controlled trial. 61
33580845 2021
44
Efficacy of vonoprazan for refractory reflux esophagitis after esophagectomy. 61
33567428 2021
45
The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis. 61
32863366 2021
46
How Does Vonoprazan Affect the Treatment of Erosive Esophagitis? 61
32535777 2021
47
Temperature Monitoring and Temperature-driven irrigated Radiofrequency Energy Titration do not prevent thermally-induced Esophageal Lesions in Pulmonary Vein Isolation A randomized study controlled by esophagoscopy before and after catheter ablation. 61
33561587 2021
48
Primary Eosinophilic Gastrointestinal Diseases Beyond Eosinophilic Esophagitis in Children. 61
32868666 2021
49
Sleep in children with eosinophilic esophagitis. 61
33565029 2021
50
Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood. 61
32766724 2021

Variations for Esophagitis

Expression for Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for Esophagitis

Pathways related to Esophagitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNF STAT6 PRG2 IL5 IL4 IL33
2
Show member pathways
13.82 TNF STAT6 PRG2 IL5 IL4 IL1B
3
Show member pathways
13.67 TSLP TNF IL5 IL4 IL33 IL1B
4
Show member pathways
13.55 TNF STAT6 IL5 IL4 IL1B IL13
5
Show member pathways
13.38 TNF STAT6 IL5 IL4 IL1B IL13
6
Show member pathways
13.36 TNF STAT6 IL5 IL4 IL33 IL1B
7
Show member pathways
13.3 TNF IL5 IL4 IL1B IL13 CXCL8
8
Show member pathways
12.87 TNF PRG2 IL5 IL4 IL1B IL13
9 12.81 STAT6 IL5 IL4 IL13 CXCL8
10
Show member pathways
12.62 TNF STAT6 IL5 IL4 IL1B IL13
11
Show member pathways
12.43 TSLP STAT6 IL5 IL4 IL13
12
Show member pathways
12.41 IL5 IL1B IL13 CAPN14
13
Show member pathways
12.37 CXCL8 CCR3 CCL26 CCL24 CCL11
14
Show member pathways
12.37 TNF CXCL8 CCR3 CCL26 CCL24 CCL11
15
Show member pathways
12.31 TNF IL5 IL4 IL1B IL13 CXCL8
16
Show member pathways
12.28 TNF IL5 IL4 IL1B IL13 CXCL8
17
Show member pathways
12.2 TNF STAT6 IL33 IL1B
18
Show member pathways
12.2 TNF IL4 IL1B CXCL8 CCL11
19 12.17 TNF IL1B IL13 CXCL8
20 12.03 TNF IL4 IL1B CXCL8
21 12.01 TNF IL5 IL4 CCR3
22 11.93 TNF IL5 IL4 IL1B
23 11.92 TNF STAT6 IL4 IL1B IL13 CXCL8
24 11.84 IL5 IL4 IL13 CXCL8
25 11.83 TNF IL1B CXCL8
26
Show member pathways
11.8 TNF IL5 IL4 CXCL8
27 11.74 TNF IL1B CXCL8
28 11.71 STAT6 IL5 IL4 CCL26 CCL11
29 11.67 TNF IL5 IL4
30
Show member pathways
11.65 TNF IL1B CXCL8
31 11.6 TNF IL1B CXCL8
32 11.6 TSLP TNF IL5 IL4 IL33 IL1B
33 11.57 TNF IL4 IL1B IL13 CXCL8
34 11.55 TSLP STAT6 CXCL8 CCL11
35 11.54 TNF IL1B CXCL8
36 11.4 STAT6 IL5 IL4 IL33 IL13 CCL11
37 11.26 TNF IL5 IL4 IL1B IL13
38 11.23 IL5 IL4 IL13
39 11.02 TNF IL5 IL4 IL1B IL13 CXCL8
40 11 TSLP TNF IL5 IL4 IL33 IL1B
41 10.97 TNF PRG2 IL5 IL4 IL1B IL13
42 10.84 IL5 IL4 IL1B IL13
43 10.36 HRH2 GAST

GO Terms for Esophagitis

Cellular components related to Esophagitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TSLP TNF PRG2 IL5 IL4 IL33
2 extracellular space GO:0005615 9.4 TSLP TNF IL5 IL4 IL33 IL1B

Biological processes related to Esophagitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.21 HRH2 GAST CXCL8 CCR3 CCL26 CCL24
2 signal transduction GO:0007165 10.1 TSLP STAT6 IL5 IL4 IL1B HRH2
3 positive regulation of gene expression GO:0010628 10.07 TNF IL4 IL33 IL1B IL13 CXCL8
4 positive regulation of cell migration GO:0030335 9.98 IL4 IL1B CCL26 CCL24 CCL11
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF CCL26 CCL24 CCL11
6 cellular response to tumor necrosis factor GO:0071356 9.94 CXCL8 CCL26 CCL24 CCL11
7 chemotaxis GO:0006935 9.88 CXCL8 CCR3 CCL26 CCL24 CCL11
8 positive regulation of interleukin-6 production GO:0032755 9.87 TSLP TNF IL33 IL1B
9 cellular response to interleukin-1 GO:0071347 9.85 CXCL8 CCL26 CCL24 CCL11
10 neutrophil chemotaxis GO:0030593 9.84 CXCL8 CCL26 CCL24 CCL11
11 positive regulation of actin filament polymerization GO:0030838 9.83 CCL26 CCL24 CCL11
12 monocyte chemotaxis GO:0002548 9.83 CCL26 CCL24 CCL11
13 positive regulation of angiogenesis GO:0045766 9.83 IL1B CXCL8 CCR3 CCL24 CCL11
14 positive regulation of B cell proliferation GO:0030890 9.82 IL5 IL4 IL13
15 positive regulation of chemokine production GO:0032722 9.81 TSLP TNF IL33
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TSLP TNF IL4 IL13
17 positive regulation of interleukin-10 production GO:0032733 9.8 TSLP IL4 IL13
18 lymphocyte chemotaxis GO:0048247 9.8 CCL26 CCL24 CCL11
19 positive regulation of endothelial cell proliferation GO:0001938 9.8 CCR3 CCL26 CCL24 CCL11
20 microglial cell activation GO:0001774 9.77 TNF IL4 IL13
21 positive regulation of inflammatory response GO:0050729 9.77 TSLP TNF IL33 IL1B CCL24
22 cytokine-mediated signaling pathway GO:0019221 9.76 TNF STAT6 IL5 IL4 IL1B IL13
23 negative regulation of neurogenesis GO:0050768 9.75 TNF IL1B CCL11
24 positive regulation of immunoglobulin production GO:0002639 9.73 IL5 IL33 IL13
25 eosinophil chemotaxis GO:0048245 9.7 CCL26 CCL24 CCL11
26 macrophage activation GO:0042116 9.69 IL4 IL13
27 positive regulation of podosome assembly GO:0071803 9.69 TNF IL5
28 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL4 IL33
29 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
30 positive regulation of interleukin-5 production GO:0032754 9.68 TSLP IL33
31 positive regulation of mast cell degranulation GO:0043306 9.68 IL4 IL13
32 vascular endothelial growth factor production GO:0010573 9.67 TNF IL1B
33 positive regulation of mononuclear cell migration GO:0071677 9.66 TNF IL4
34 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
35 sequestering of triglyceride GO:0030730 9.65 TNF IL1B
36 chemokine-mediated signaling pathway GO:0070098 9.65 CXCL8 CCR3 CCL26 CCL24 CCL11
37 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL33 IL1B
38 negative regulation of complement-dependent cytotoxicity GO:1903660 9.62 IL4 IL13
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
40 positive regulation of isotype switching to IgE isotypes GO:0048295 9.61 STAT6 IL4
41 inflammatory response GO:0006954 9.61 TNF IL5 IL1B IL13 CXCL8 CCR3
42 positive regulation of interleukin-13 production GO:0032736 9.58 TSLP IL4 IL33
43 immune response GO:0006955 9.4 TNF PRG2 IL5 IL4 IL1B IL13

Molecular functions related to Esophagitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor ligand activity GO:0048018 9.5 CCL26 CCL24 CCL11
2 chemokine activity GO:0008009 9.46 CXCL8 CCL26 CCL24 CCL11
3 CCR chemokine receptor binding GO:0048020 9.43 CCL26 CCL24 CCL11
4 cytokine activity GO:0005125 9.36 TSLP TNF IL5 IL4 IL33 IL1B
5 CCR3 chemokine receptor binding GO:0031728 9.13 CCL26 CCL24 CCL11

Sources for Esophagitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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