MCID: ESP005
MIFTS: 29

Esophagus Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophagus Carcinoma in Situ

MalaCards integrated aliases for Esophagus Carcinoma in Situ:

Name: Esophagus Carcinoma in Situ 12 15
Carcinoma in Situ of Esophagus 12 71
Stage 0 Carcinoma of the Oesophagus 12
Stage 0 Carcinoma of the Esophagus 12
Carcinoma in Situ of Oesophagus 12
Oesophagus Carcinoma in Situ 12
Severe Esophageal Dysplasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9095
ICD9CM 34 230.1
SNOMED-CT 67 92585006
ICD10 32 D00.1
UMLS 71 C0154059

Summaries for Esophagus Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the esophagus.

MalaCards based summary : Esophagus Carcinoma in Situ, also known as carcinoma in situ of esophagus, is related to inflammatory bowel disease 27 and hereditary leiomyomatosis and renal cell cancer. An important gene associated with Esophagus Carcinoma in Situ is ODC1 (Ornithine Decarboxylase 1), and among its related pathways/superpathways are Pathways in cancer and Angiogenesis (CST). Affiliated tissues include esophagus and trachea, and related phenotypes are mortality/aging and growth/size/body region

Related Diseases for Esophagus Carcinoma in Situ

Diseases related to Esophagus Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 27 10.0 HIF1A EPO
2 hereditary leiomyomatosis and renal cell cancer 10.0 LDHA HIF1A
3 primary polycythemia 10.0 HIF1A EPO
4 cerebral artery occlusion 9.9 ODC1 HIF1A
5 stress polycythemia 9.9 LDHA EPO
6 megaesophagus 9.9
7 in situ carcinoma 9.9
8 brain injury 9.8 EPO ENO1
9 erythrocytosis, familial, 2, autosomal recessive 9.7 HIF1A EPO ARNT
10 ischemic colitis 9.6 HMOX1 HIF1A
11 sickle cell disease 9.6 EPO BCAM
12 pulmonary edema 9.4 HMOX1 HIF1A EPO
13 restless legs syndrome 9.3 HMOX1 HIF1A EPO
14 clear cell renal cell carcinoma 9.3 LDHA HIF1A EPO ARNT
15 cardiac arrest 9.3 HMOX1 EPO ENO1
16 deficiency anemia 9.2 HMOX1 HIF1A EPO

Comorbidity relations with Esophagus Carcinoma in Situ via Phenotypic Disease Network (PDN):


Esophageal Disease

Graphical network of the top 20 diseases related to Esophagus Carcinoma in Situ:



Diseases related to Esophagus Carcinoma in Situ

Symptoms & Phenotypes for Esophagus Carcinoma in Situ

MGI Mouse Phenotypes related to Esophagus Carcinoma in Situ:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.15 ARNT BCAM COL27A1 CTNND1 ENO1 EPO
2 growth/size/body region MP:0005378 10.13 ARNT BCAM COL27A1 ENO1 HIF1A HMOX1
3 cardiovascular system MP:0005385 10.1 ARNT BCAM EPO HIF1A HMOX1 LDHA
4 cellular MP:0005384 10.08 ARNT CTNND1 EPO HIF1A HMOX1 ODC1
5 embryo MP:0005380 10 ARNT COL27A1 ENO1 EPO HIF1A ODC1
6 limbs/digits/tail MP:0005371 9.8 COL27A1 EPO HIF1A POSTN PSEN1
7 normal MP:0002873 9.8 ARNT BCAM EPO HIF1A LDHA ODC1
8 neoplasm MP:0002006 9.72 ARNT CTNND1 HIF1A LDHA POSTN
9 renal/urinary system MP:0005367 9.63 ARNT BCAM CTNND1 HIF1A HMOX1 PSEN1
10 reproductive system MP:0005389 9.5 ARNT BCAM COL27A1 FABP9 HMOX1 POSTN
11 respiratory system MP:0005388 9.1 COL27A1 EPO HIF1A HMOX1 LDHA PSEN1

Drugs & Therapeutics for Esophagus Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Esophagus Carcinoma in Situ

Genetic Tests for Esophagus Carcinoma in Situ

Anatomical Context for Esophagus Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Esophagus Carcinoma in Situ:

19
Esophagus

MalaCards organs/tissues related to Esophagus Carcinoma in Situ:

40
Trachea

Publications for Esophagus Carcinoma in Situ

Articles related to Esophagus Carcinoma in Situ:

# Title Authors PMID Year
1
Synchronous primary cancers of trachea and esophagus and ventricular tachycardia. 61
25035663 2014
2
Multiphoton microscopic imaging of esophagus during the early phase of tumor progression. 61
23427072 2013

Variations for Esophagus Carcinoma in Situ

Expression for Esophagus Carcinoma in Situ

Search GEO for disease gene expression data for Esophagus Carcinoma in Situ.

Pathways for Esophagus Carcinoma in Situ

GO Terms for Esophagus Carcinoma in Situ

Biological processes related to Esophagus Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.67 PSEN1 HMOX1 HIF1A
2 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.61 HIF1A EPO ARNT
3 response to estrogen GO:0043627 9.58 LDHA HMOX1 EPO
4 glycolytic process GO:0006096 9.57 LDHA ENO1
5 positive regulation of erythrocyte differentiation GO:0045648 9.56 HIF1A ARNT
6 positive regulation of macroautophagy GO:0016239 9.55 HMOX1 HIF1A
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.54 HIF1A ARNT
8 embryonic placenta development GO:0001892 9.52 HIF1A ARNT
9 response to muscle activity GO:0014850 9.51 POSTN HIF1A
10 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.48 HIF1A ARNT
11 mRNA transcription by RNA polymerase II GO:0042789 9.46 HIF1A ARNT
12 hemoglobin biosynthetic process GO:0042541 9.37 HIF1A EPO
13 positive regulation of glycolytic process GO:0045821 9.33 PSEN1 HIF1A ARNT
14 lactate metabolic process GO:0006089 9.32 LDHA HIF1A
15 positive regulation of hormone biosynthetic process GO:0046886 9.26 HIF1A ARNT
16 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.13 HMOX1 HIF1A ARNT
17 response to hypoxia GO:0001666 9.1 POSTN LDHA HMOX1 HIF1A EPO ARNT

Molecular functions related to Esophagus Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.92 PSEN1 LDHA ENO1 CTNND1

Sources for Esophagus Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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