MCID: ESP005
MIFTS: 30

Esophagus Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophagus Carcinoma in Situ

MalaCards integrated aliases for Esophagus Carcinoma in Situ:

Name: Esophagus Carcinoma in Situ 12 15
Carcinoma in Situ of Esophagus 12 71
Stage 0 Carcinoma of the Oesophagus 12
Stage 0 Carcinoma of the Esophagus 12
Carcinoma in Situ of Oesophagus 12
Oesophagus Carcinoma in Situ 12
Severe Esophageal Dysplasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9095
ICD9CM 34 230.1
SNOMED-CT 67 92585006
ICD10 32 D00.1
UMLS 71 C0154059

Summaries for Esophagus Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the esophagus.

MalaCards based summary : Esophagus Carcinoma in Situ, also known as carcinoma in situ of esophagus, is related to lumbosacral lipoma and inflammatory bowel disease 27. An important gene associated with Esophagus Carcinoma in Situ is ODC1 (Ornithine Decarboxylase 1), and among its related pathways/superpathways are Pathways in cancer and Angiogenesis (CST). Affiliated tissues include esophagus and trachea, and related phenotypes are cellular and cardiovascular system

Related Diseases for Esophagus Carcinoma in Situ

Graphical network of the top 20 diseases related to Esophagus Carcinoma in Situ:



Diseases related to Esophagus Carcinoma in Situ

Symptoms & Phenotypes for Esophagus Carcinoma in Situ

MGI Mouse Phenotypes related to Esophagus Carcinoma in Situ:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 ARNT CTNND1 EPO HIF1A HMOX1 IL2
2 cardiovascular system MP:0005385 10.13 ARNT EPO HIF1A HMOX1 IL2 LDHA
3 growth/size/body region MP:0005378 10.11 ARNT ENO1 HIF1A HMOX1 IL2 LDHA
4 embryo MP:0005380 10.04 ARNT ENO1 EPO HIF1A HMOX1 ODC1
5 hematopoietic system MP:0005397 10.03 ARNT EPO HIF1A HMOX1 IL2 LDHA
6 endocrine/exocrine gland MP:0005379 10.02 ARNT CTNND1 HIF1A HMOX1 IL2 POSTN
7 immune system MP:0005387 10.01 ARNT EPO HIF1A HMOX1 IL2 LDHA
8 mortality/aging MP:0010768 10 ARNT CTNND1 ENO1 EPO HIF1A HMOX1
9 liver/biliary system MP:0005370 9.8 ARNT EPO HIF1A HMOX1 IL2 LDHA
10 limbs/digits/tail MP:0005371 9.77 EPO HIF1A HMOX1 POSTN PSEN1
11 neoplasm MP:0002006 9.63 ARNT CTNND1 HIF1A IL2 LDHA POSTN
12 normal MP:0002873 9.43 ARNT EPO HIF1A LDHA ODC1 PSEN1
13 respiratory system MP:0005388 9.1 EPO HIF1A HMOX1 IL2 LDHA PSEN1

Drugs & Therapeutics for Esophagus Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Esophagus Carcinoma in Situ

Genetic Tests for Esophagus Carcinoma in Situ

Anatomical Context for Esophagus Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Esophagus Carcinoma in Situ:

19
Esophagus

MalaCards organs/tissues related to Esophagus Carcinoma in Situ:

40
Trachea

Publications for Esophagus Carcinoma in Situ

Articles related to Esophagus Carcinoma in Situ:

# Title Authors PMID Year
1
Synchronous primary cancers of trachea and esophagus and ventricular tachycardia. 61
25035663 2014
2
Multiphoton microscopic imaging of esophagus during the early phase of tumor progression. 61
23427072 2013

Variations for Esophagus Carcinoma in Situ

Expression for Esophagus Carcinoma in Situ

Search GEO for disease gene expression data for Esophagus Carcinoma in Situ.

Pathways for Esophagus Carcinoma in Situ

GO Terms for Esophagus Carcinoma in Situ

Biological processes related to Esophagus Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.91 PSEN1 HIF1A EPO ARNT
2 cell adhesion GO:0007155 9.9 PSEN1 POSTN IL2 CTNND1
3 negative regulation of apoptotic process GO:0043066 9.84 PSEN1 IL2 HIF1A EPO
4 negative regulation of neuron apoptotic process GO:0043524 9.65 PSEN1 HMOX1 HIF1A
5 gene expression GO:0010467 9.61 PSEN1 IL2
6 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.61 HIF1A EPO ARNT
7 positive regulation of chemokine production GO:0032722 9.59 HMOX1 HIF1A
8 glycolytic process GO:0006096 9.58 LDHA ENO1
9 positive regulation of erythrocyte differentiation GO:0045648 9.58 HIF1A ARNT
10 positive regulation of macroautophagy GO:0016239 9.57 HMOX1 HIF1A
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.56 HIF1A ARNT
12 positive regulation of activated T cell proliferation GO:0042104 9.55 IL2 EPO
13 response to estrogen GO:0043627 9.54 LDHA HMOX1 EPO
14 positive regulation of dendritic spine development GO:0060999 9.52 PSEN1 IL2
15 response to muscle activity GO:0014850 9.51 POSTN HIF1A
16 embryonic placenta development GO:0001892 9.49 HIF1A ARNT
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.46 HIF1A ARNT
18 hemoglobin biosynthetic process GO:0042541 9.4 HIF1A EPO
19 positive regulation of glycolytic process GO:0045821 9.33 PSEN1 HIF1A ARNT
20 lactate metabolic process GO:0006089 9.32 LDHA HIF1A
21 positive regulation of hormone biosynthetic process GO:0046886 9.26 HIF1A ARNT
22 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.13 HMOX1 HIF1A ARNT
23 response to hypoxia GO:0001666 9.1 POSTN LDHA HMOX1 HIF1A EPO ARNT

Molecular functions related to Esophagus Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.26 ODC1 HMOX1 ENO1 ARNT
2 cadherin binding GO:0045296 8.92 PSEN1 LDHA ENO1 CTNND1

Sources for Esophagus Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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