MCID: ESP016
MIFTS: 23

Esophagus Melanoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Esophagus Melanoma

MalaCards integrated aliases for Esophagus Melanoma:

Name: Esophagus Melanoma 12 15
Melanoma of Oesophagus 12
Melanoma of Esophagus 12
Oesophagus Melanoma 12
Esophageal Melanoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1108
NCIt 50 C5707
UMLS 71 C1333460

Summaries for Esophagus Melanoma

MalaCards based summary : Esophagus Melanoma, also known as melanoma of oesophagus, is related to melanoma and dysphagia. An important gene associated with Esophagus Melanoma is CDX1 (Caudal Type Homeobox 1). Affiliated tissues include heart, and related phenotypes are digestive/alimentary and pigmentation

Related Diseases for Esophagus Melanoma

Diseases related to Esophagus Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.3
2 dysphagia 10.1
3 rare tumor 10.0
4 vagus nerve disease 9.9 ATP4A ATP12A
5 necrotizing gastritis 9.9 ATP4A ATP12A
6 scalp dermatosis 9.9 ATP4A ATP12A
7 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
8 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
9 lingual goiter 9.9 ATP4A ATP12A
10 displacement of cardia through esophageal hiatus 9.9 ATP4A ATP12A
11 bacterial esophagitis 9.9 ATP4A ATP12A
12 cascade stomach 9.9 ATP4A ATP12A
13 benzylpenicillin allergy 9.9 ATP4A ATP12A
14 median arcuate ligament syndrome 9.9 ATP4A ATP12A
15 afferent loop syndrome 9.9 ATP4A ATP12A
16 cervix erosion 9.9 ATP4A ATP12A
17 angiodysplasia of intestine 9.9 ATP4A ATP12A
18 angiodysplasia 9.9 ATP4A ATP12A
19 granulomatous gastritis 9.9 ATP4A ATP12A
20 laryngeal tuberculosis 9.9 ATP4A ATP12A
21 fungal esophagitis 9.9 ATP4A ATP12A
22 dieulafoy lesion 9.9 ATP4A ATP12A
23 cefuroxime allergy 9.9 ATP4A ATP12A
24 emphysematous cholecystitis 9.9 ATP4A ATP12A
25 gastric gastrinoma 9.9 ATP4A ATP12A
26 superior mesenteric artery syndrome 9.9 ATP4A ATP12A
27 pneumatosis cystoides intestinalis 9.9 ATP4A ATP12A
28 chronic laryngitis 9.9 ATP4A ATP12A
29 laryngitis 9.9 ATP4A ATP12A
30 viral laryngitis 9.9 ATP4A ATP12A
31 gastroduodenal crohn's disease 9.9 ATP4A ATP12A
32 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9 ATP4A ATP12A
33 central nervous system origin vertigo 9.9 ATP4A ATP12A
34 rumination disorder 9.9 ATP4A ATP12A
35 internal hemorrhoid 9.9 ATP4A ATP12A
36 acute laryngitis 9.9 ATP4A ATP12A
37 gastroduodenitis 9.9 ATP4A ATP12A
38 chronic intestinal vascular insufficiency 9.9 ATP4A ATP12A
39 barbiturate abuse 9.9 ATP4A ATP12A
40 duodenal gastrinoma 9.9 ATP4A ATP12A
41 gastric dilatation 9.9 ATP4A ATP12A
42 gastric hemangioma 9.9 ATP4A ATP12A
43 blind loop syndrome 9.9 ATP4A ATP12A
44 polycystic echinococcosis 9.9 ATP4A ATP12A
45 diclofenac allergy 9.9 ATP4A ATP12A
46 x-linked chondrodysplasia punctata 1 9.9 ATP4A ATP12A
47 mediastinitis 9.9 ATP4A ATP12A
48 pancreatic gastrinoma 9.9 ATP4A ATP12A
49 duodenal obstruction 9.9 ATP4A ATP12A
50 epidermolysis bullosa simplex, ogna type 9.9 ATP4A ATP12A

Graphical network of the top 20 diseases related to Esophagus Melanoma:



Diseases related to Esophagus Melanoma

Symptoms & Phenotypes for Esophagus Melanoma

MGI Mouse Phenotypes related to Esophagus Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 ATP12A ATP4A CDX1 FAS
2 pigmentation MP:0001186 8.8 CDX1 FAS MLANA

Drugs & Therapeutics for Esophagus Melanoma

Search Clinical Trials , NIH Clinical Center for Esophagus Melanoma

Genetic Tests for Esophagus Melanoma

Anatomical Context for Esophagus Melanoma

MalaCards organs/tissues related to Esophagus Melanoma:

40
Heart

Publications for Esophagus Melanoma

Articles related to Esophagus Melanoma:

# Title Authors PMID Year
1
Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers. 61
33414988 2020
2
Cardiac tamponade as an initial presentation of papillary carcinoma with psammoma bodies and intranuclear grooves-A diagnostic dilemma. 61
31120622 2019
3
Metastatic squamous cell carcinoma to the heart: an unusual cause of ST elevation-a case report. 61
31449588 2019
4
Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. 61
21285870 2011
5
[Diagnostic and therapeutic difficulties in a patient with primary malignant melanoma of the esophagus--case report]. 61
15690707 2004
6
[Primary melanoma of the esophagus. Unusual case with Barrett's esophagus]. 61
11917448 2001
7
[Leptomeningeal carcinomatosis as presenting symptom of a gallbladder carcinoma]. 61
10870198 2000
8
Comparison of radionuclide bone scans and magnetic resonance imaging in detecting spinal metastases. 61
8254410 1993
9
[Production of monoclonal antibodies specific to human lung cancer--squamous cell carcinoma and adenocarcinoma]. 61
6521722 1984
10
[Primary malignant melanoma of the esophagus associated with melanosis of the esophagus and stomach]. 61
6535357 1984

Variations for Esophagus Melanoma

Expression for Esophagus Melanoma

Search GEO for disease gene expression data for Esophagus Melanoma.

Pathways for Esophagus Melanoma

GO Terms for Esophagus Melanoma

Biological processes related to Esophagus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.37 S100A8 FAS
2 potassium ion import across plasma membrane GO:1990573 9.32 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Esophagus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Esophagus Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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