MCID: ESP026
MIFTS: 32

Esophagus Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophagus Sarcoma

MalaCards integrated aliases for Esophagus Sarcoma:

Name: Esophagus Sarcoma 12 15
Esophageal Sarcoma 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1114
NCIt 50 C5341
UMLS 70 C1333466

Summaries for Esophagus Sarcoma

Disease Ontology : 12 An esophageal cancer that arises from transformed cells of mesenchymal origin sarcoma and located in the esophagus.

MalaCards based summary : Esophagus Sarcoma, also known as esophageal sarcoma, is related to spindle cell sarcoma and sarcoma, synovial. An important gene associated with Esophagus Sarcoma is CPM (Carboxypeptidase M), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include esophagus, breast and small intestine, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Esophagus Sarcoma

Diseases related to Esophagus Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.2 SSX2 KIT CD34 CALD1
2 sarcoma, synovial 30.0 SSX2 KIT CD34
3 myxofibrosarcoma 29.8 SSX2 KIT CD34 CALD1
4 liposarcoma 29.8 MSH2 CPM CD34
5 rhabdomyosarcoma 28.7 SSX2 PMS2 MSH6 MSH2 MAPK1 KIT
6 urethra leiomyoma 10.4 KIT CALD1
7 prostate embryonal rhabdomyosarcoma 10.4 KIT CALD1
8 spinal cord sarcoma 10.4 KIT CD34
9 gallbladder leiomyoma 10.4 KIT CD34
10 gastric leiomyoma 10.3 KIT CALD1
11 small intestine leiomyosarcoma 10.3 KIT CD34
12 neuronal intestinal dysplasia, type b 10.3 KIT CD34
13 glomangioma 10.3 CD34 CALD1
14 gastric liposarcoma 10.3 KIT CD34
15 mucocele of appendix 10.3 KIT CD34
16 benign fibrous mesothelioma 10.3 KIT CD34
17 intravascular angioleiomyoma 10.3 CD34 CALD1
18 retroperitoneal hemangiopericytoma 10.3 KIT CD34
19 breast myofibroblastoma 10.3 CD34 CALD1
20 jejunal neoplasm 10.3 KIT CD34
21 liver leiomyoma 10.3 KIT CD34
22 kidney hemangiopericytoma 10.3 SSX2 CD34
23 pulmonary vein leiomyosarcoma 10.3 CD34 CALD1
24 plexiform schwannoma 10.3 KIT CD34
25 glomangiomyoma 10.3 CD34 CALD1
26 cutaneous ganglioneuroma 10.3 KIT CD34
27 vulvar leiomyosarcoma 10.3 CD34 CALD1
28 peritoneal benign neoplasm 10.3 CD34 CALD1
29 spindle cell synovial sarcoma 10.3 SSX2 CD34
30 glomangiosarcoma 10.3 CD34 CALD1
31 nasal cavity benign neoplasm 10.3 KIT CD34
32 adult fibrosarcoma 10.3 CD34 CALD1
33 prostate stromal sarcoma 10.3 KIT CD34
34 cervical polyp 10.3 CD34 CALD1
35 lung sarcoma 10.3 SSX2 CD34
36 benign breast phyllodes tumor 10.3 KIT CD34
37 intravenous leiomyomatosis 10.3 CD34 CALD1
38 congenital granular cell tumor 10.3 CD34 CALD1
39 cutaneous leiomyosarcoma 10.3 CD34 CALD1
40 subungual glomus tumor 10.3 CD34 CALD1
41 vulvar leiomyoma 10.3 CD34 CALD1
42 infiltrating angiolipoma 10.3 CD34 CALD1
43 angiolipoma 10.3 CD34 CALD1
44 intravascular fasciitis 10.3 CD34 CALD1
45 small intestine benign neoplasm 10.3 KIT CD34
46 extraosseous osteosarcoma 10.3 CD34 CALD1
47 meckel diverticulum 10.3 KIT CD34
48 epithelioid malignant peripheral nerve sheath tumor 10.3 SSX2 CD34
49 lymphoepithelioma-like thymic carcinoma 10.3 KRT5 KIT
50 mediastinal cancer 10.3 KIT CD34

Graphical network of the top 20 diseases related to Esophagus Sarcoma:



Diseases related to Esophagus Sarcoma

Symptoms & Phenotypes for Esophagus Sarcoma

GenomeRNAi Phenotypes related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10 FHIT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10 MAPK1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10 FHIT
4 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10 MAPK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10 FHIT KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10 FHIT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10 FHIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10 KIT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-171 10 FHIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10 FHIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10 FHIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10 KIT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-48 10 FHIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10 MAPK1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10 KIT
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10 FHIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10 KIT MAPK1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10 KIT
21 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.92 CPM ECE1 MAPK1 MSH2

MGI Mouse Phenotypes related to Esophagus Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 ECE1 FHIT KIT KRT5 MAPK1 MSH2
2 integument MP:0010771 9.61 CD34 ECE1 FHIT KIT KRT5 MAPK1
3 neoplasm MP:0002006 9.17 CD34 FHIT KIT MAPK1 MSH2 MSH6

Drugs & Therapeutics for Esophagus Sarcoma

Search Clinical Trials , NIH Clinical Center for Esophagus Sarcoma

Genetic Tests for Esophagus Sarcoma

Anatomical Context for Esophagus Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Esophagus Sarcoma:

19
Esophagus

MalaCards organs/tissues related to Esophagus Sarcoma:

40
Breast, Small Intestine, Colon, Skin, Liver, Thymus, Heart

Publications for Esophagus Sarcoma

Articles related to Esophagus Sarcoma:

(show all 20)
# Title Authors PMID Year
1
Early-phase nano-genosensing of cell-free nucleobiomarkers in the plasma of cancerous patients. 61
33253921 2020
2
Surgical management of esophageal sarcoma: a multicenter European experience. 61
29444281 2018
3
A Population-Based Examination of the Surgical Outcomes for Patients with Esophageal Sarcoma. 61
26310279 2015
4
Rare Cause of Stricture Esophagus-Sarcoma: A Case Report and Review of the literature. 61
22606414 2011
5
Ocular toxicities of epidermal growth factor receptor inhibitors and their management. 61
17666986 2007
6
Transthoracic esophagectomy and lobectomy performed in a patient with synchronous lung cancer and combined esophageal cancer and esophageal leiomyosarcoma. 61
17161608 2007
7
[Malignant nerve sheath tumor of the esophagus (malignant esophageal schwannoma)]. 61
15388051 2004
8
Partial esophagectomy with single layer closure for treatment of esophageal sarcomas in 6 dogs. 61
15230849 2004
9
Radiation-induced gastrointestinal stromal sarcoma of the esophagus. 61
10969699 2000
10
Transesophageal echocardiography detection of an esophageal sarcoma mimicking aortic dissection. 61
10849517 2000
11
Synovial sarcoma of the esophagus simulating achalasia. 61
10071812 1998
12
Unusual malignant neoplasms of the esophagus. Oat cell carcinoma, melanoma, and sarcoma. 61
1702494 1991
13
[Esophageal sarcoma in Zenker's diverticulum. Difficult diagnosis of a rare disease picture]. 61
6212512 1982
14
Visceral lesions in wild carnivores naturally infected with Spirocerca lupi. 61
685080 1978
15
Polypoid sarcomas of the esophagus. A rare but potentially curable neoplasm. 61
1180595 1975
16
[Esophageal sarcoma]. 61
6072724 1967
17
[Studies on esophageal sarcoma]. 61
12983304 1952
18
[Polyp-like tumors of the esophagus: sarcoma, melanoma, mixed tumor and double tumor]. 61
14917025 1951
19
A case of esophagus sarcoma. 61
18894252 1948
20
Primary esophageal sarcoma. 61
18893365 1948

Variations for Esophagus Sarcoma

Expression for Esophagus Sarcoma

Search GEO for disease gene expression data for Esophagus Sarcoma.

Pathways for Esophagus Sarcoma

GO Terms for Esophagus Sarcoma

Cellular components related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
2 mismatch repair complex GO:0032300 8.8 PMS2 MSH6 MSH2

Biological processes related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.54 MSH2 KIT IL11
2 determination of adult lifespan GO:0008340 9.46 MSH6 MSH2
3 negative regulation of DNA recombination GO:0045910 9.43 MSH6 MSH2
4 isotype switching GO:0045190 9.4 MSH6 MSH2
5 positive regulation of helicase activity GO:0051096 9.32 MSH6 MSH2
6 maintenance of DNA repeat elements GO:0043570 9.26 MSH6 MSH2
7 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MSH6 MSH2
8 mismatch repair GO:0006298 9.13 PMS2 MSH6 MSH2
9 somatic hypermutation of immunoglobulin genes GO:0016446 8.8 PMS2 MSH6 MSH2

Molecular functions related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.61 MSH6 MSH2 MAPK1
2 four-way junction DNA binding GO:0000400 9.4 MSH6 MSH2
3 MutLalpha complex binding GO:0032405 9.37 MSH6 MSH2
4 oxidized purine DNA binding GO:0032357 9.32 MSH6 MSH2
5 guanine/thymine mispair binding GO:0032137 9.26 MSH6 MSH2
6 single guanine insertion binding GO:0032142 9.16 MSH6 MSH2
7 single thymine insertion binding GO:0032143 8.96 MSH6 MSH2
8 mismatched DNA binding GO:0030983 8.8 PMS2 MSH6 MSH2

Sources for Esophagus Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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