MCID: ESP026
MIFTS: 22

Esophagus Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophagus Sarcoma

MalaCards integrated aliases for Esophagus Sarcoma:

Name: Esophagus Sarcoma 12 15
Esophageal Sarcoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1114
NCIt 50 C5341
UMLS 73 C1333466

Summaries for Esophagus Sarcoma

Disease Ontology : 12 An esophageal cancer that arises from transformed cells of mesenchymal origin sarcoma and located in the esophagus.

MalaCards based summary : Esophagus Sarcoma, also known as esophageal sarcoma, is related to sarcoma and conventional fibrosarcoma. An important gene associated with Esophagus Sarcoma is WWOX (WW Domain Containing Oxidoreductase), and among its related pathways/superpathways are Cushing syndrome and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Affiliated tissues include bone, heart and the esophagus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Esophagus Sarcoma

Diseases related to Esophagus Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.6 KIT CREB3L2
2 conventional fibrosarcoma 9.9 KIT CREB3L2
3 spindle cell liposarcoma 9.9 KIT CREB3L2
4 heart sarcoma 9.9 KIT CREB3L2
5 fibrosarcoma of bone 9.8 KIT CREB3L2
6 muscle cancer 9.8 KIT CREB3L2
7 gastric cardia carcinoma 9.8 WWOX KIT
8 connective tissue cancer 9.8 KIT CREB3L2
9 gastrointestinal system cancer 9.8 WWOX KIT
10 gastrointestinal system disease 9.7 WWOX KIT
11 muscular disease 9.7 KIT CREB3L2

Graphical network of the top 20 diseases related to Esophagus Sarcoma:



Diseases related to Esophagus Sarcoma

Symptoms & Phenotypes for Esophagus Sarcoma

GenomeRNAi Phenotypes related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.55 KIT WWOX
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.55 WWOX
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.55 WWOX
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.55 WWOX
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.55 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.55 KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.55 WWOX
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.55 WWOX
9 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.55 KIT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.55 WWOX
11 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.55 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 WWOX
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.55 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.55 KIT
17 Increased gamma-H2AX phosphorylation GR00053-A 9.13 CREB3L2 KIT WWOX

MGI Mouse Phenotypes related to Esophagus Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 8.8 CREB3L2 KIT WWOX

Drugs & Therapeutics for Esophagus Sarcoma

Search Clinical Trials , NIH Clinical Center for Esophagus Sarcoma

Genetic Tests for Esophagus Sarcoma

Anatomical Context for Esophagus Sarcoma

MalaCards organs/tissues related to Esophagus Sarcoma:

41
Bone, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Esophagus Sarcoma:

19
The Esophagus

Publications for Esophagus Sarcoma

Articles related to Esophagus Sarcoma:

# Title Authors Year
1
Surgical management of esophageal sarcoma: a multicenter European experience. ( 29444281 )
2018
2
A Population-Based Examination of the Surgical Outcomes for Patients with Esophageal Sarcoma. ( 26310279 )
2015
3
Rare Cause of Stricture Esophagus-Sarcoma: A Case Report and Review of the literature. ( 22606414 )
2011
4
Transesophageal echocardiography detection of an esophageal sarcoma mimicking aortic dissection. ( 10849517 )
2000

Variations for Esophagus Sarcoma

Expression for Esophagus Sarcoma

Search GEO for disease gene expression data for Esophagus Sarcoma.

Pathways for Esophagus Sarcoma

GO Terms for Esophagus Sarcoma

Biological processes related to Esophagus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.62 CREB3L2 KIT

Sources for Esophagus Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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