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MCID: ESP011
MIFTS: 35

Esophagus Verrucous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Esophagus Verrucous Carcinoma

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MalaCards integrated aliases for Esophagus Verrucous Carcinoma:

Name: Esophagus Verrucous Carcinoma 12 15
Verrucous Carcinoma of the Esophagus 12
Verrucous Carcinoma of Oesophagus 12
Verrucous Carcinoma of Esophagus 12
Oesophagus Verrucous Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3747
NCIt 50 C27420
UMLS 70 C1333470
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Summaries for Esophagus Verrucous Carcinoma

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MalaCards based summary : Esophagus Verrucous Carcinoma, also known as verrucous carcinoma of the esophagus, is related to squamous cell papilloma and megaesophagus. An important gene associated with Esophagus Verrucous Carcinoma is GIT2 (GIT ArfGAP 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include breast, lung and bone, and related phenotypes are cellular and cardiovascular system

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Related Diseases for Esophagus Verrucous Carcinoma

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Diseases related to Esophagus Verrucous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.4 TP53 CDKN2A
2 megaesophagus 30.3 TP53 CDKN2A
3 barrett esophagus 29.9 TP53 CDKN2A CCND1
4 verrucous carcinoma 29.9 TP53 MDM2 EGFR CDKN2A CCND1
5 papilloma 29.2 TP53 EGFR CDKN2A CCND1
6 esophageal disease 29.2 TP53 EGFR CDH1 CCND1
7 gastroesophageal reflux 29.1 TP53 MDM2 EGFR CCND1
8 squamous cell carcinoma 28.9 TP53 EGFR CDKN2A CDH1 CCND1
9 esophageal cancer 28.8 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
10 dysphagia 10.4
11 epstein-barr virus-associated gastric carcinoma 10.2 CDKN2A CDH1
12 maxillary sinus benign neoplasm 10.2 CDKN2A CDH1
13 acanthoma 10.2 TP53 CDKN2A
14 mediastinum liposarcoma 10.2 MDM2 CDKN2A
15 ovarian seromucinous carcinoma 10.2 TP53 CDKN2A
16 human papillomavirus infectious disease 10.2 TP53 CDKN2A
17 spitz nevus 10.2 TP53 CDKN2A
18 inflammatory liposarcoma 10.2 MDM2 CDKN2A
19 pancreas sarcoma 10.2 MDM2 CDKN2A
20 penile benign neoplasm 10.1 TP53 CDKN2A
21 bizarre leiomyoma 10.1 TP53 CDKN2A
22 infiltrating angiolipoma 10.1 MDM2 CDKN2A
23 adult malignant schwannoma 10.1 TP53 CDKN2A
24 suppressor of tumorigenicity 3 10.1 TP53 CDKN2A
25 hereditary melanoma 10.1 MDM2 CDKN2A
26 localized osteosarcoma 10.1 TP53 CDKN2A
27 malignant exocrine pancreas neoplasm 10.1 TP53 CDKN2A
28 ovarian brenner tumor 10.1 MDM2 CDKN2A
29 chronic cervicitis 10.1 TP53 CDKN2A
30 thyroid lymphoma 10.1 TP53 CDKN2A
31 bladder clear cell adenocarcinoma 10.1 TP53 CDKN2A
32 sarcomatoid transitional cell carcinoma 10.1 TP53 CDH1
33 male reproductive organ benign neoplasm 10.1 TP53 CDKN2A
34 bile duct adenoma 10.1 TP53 CDKN2A
35 vaginal cancer 10.1 TP53 CDKN2A
36 lung giant cell carcinoma 10.1 CDKN2A CDH1
37 nasal cavity adenocarcinoma 10.1 TP53 CDKN2A
38 low-grade astrocytoma 10.1 TP53 CDKN2A
39 gliofibroma 10.1 TP53 CDKN2A
40 retroperitoneum carcinoma 10.1 MDM2 CDKN2A
41 nasal cavity cancer 10.1 TP53 CDKN2A
42 prostate squamous cell carcinoma 10.1 TP53 CDKN2A
43 neurofibrosarcoma 10.1 TP53 CDKN2A
44 vulvar dystrophy 10.1 TP53 CDKN2A
45 esophageal adenosquamous carcinoma 10.1 TP53 CDH1
46 ring chromosome 7 10.1 TP53 MDM2
47 ring chromosome 10.1 TP53 MDM2
48 uterus carcinoma in situ 10.1 TP53 CDKN2A
49 cervix uteri carcinoma in situ 10.1 TP53 CDKN2A
50 bowenoid papulosis 10.1 CDKN2A CCND1

Graphical network of the top 20 diseases related to Esophagus Verrucous Carcinoma:



Diseases related to Esophagus Verrucous Carcinoma
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Symptoms & Phenotypes for Esophagus Verrucous Carcinoma

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MGI Mouse Phenotypes related to Esophagus Verrucous Carcinoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2
2 cardiovascular system MP:0005385 9.99 CCND1 CDH1 CDKN2A EGFR MDM2 TP53
3 immune system MP:0005387 9.98 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2
4 digestive/alimentary MP:0005381 9.95 CCND1 CDH1 CDKN2A EGFR MDM2 TP53
5 integument MP:0010771 9.95 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2
6 endocrine/exocrine gland MP:0005379 9.93 CCND1 CDH1 CDKN2A EGFR MDM2 TP53
7 neoplasm MP:0002006 9.85 CCND1 CDH1 CDKN2A EGFR MDM2 TP53
8 normal MP:0002873 9.73 CCND1 CDH1 EGFR GIT2 MDM2 TP53
9 no phenotypic analysis MP:0003012 9.72 CDH1 CDKN2A EGFR MDM2 TP53
10 pigmentation MP:0001186 9.46 CDKN2A EGFR MDM2 TP53
11 reproductive system MP:0005389 9.43 CCND1 CDH1 CDKN2A EGFR MDM2 TP53
12 respiratory system MP:0005388 9.02 CCND1 CDKN2A EGFR GIT2 TP53
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Drugs & Therapeutics for Esophagus Verrucous Carcinoma

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Search Clinical Trials , NIH Clinical Center for Esophagus Verrucous Carcinoma

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Genetic Tests for Esophagus Verrucous Carcinoma

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Anatomical Context for Esophagus Verrucous Carcinoma

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MalaCards organs/tissues related to Esophagus Verrucous Carcinoma:

40
Breast, Lung, Bone, Thyroid, Skin, Tongue, Thymus
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Publications for Esophagus Verrucous Carcinoma

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Articles related to Esophagus Verrucous Carcinoma:

(show all 26)
# Title Authors PMID Year
1
Verrucous carcinoma of the esophagus - a case report and literature review. 61
33036050 2020
2
Verrucous carcinoma of the esophagus: a case report and literature review. 61
32030515 2020
3
Human papillomavirus infection is not involved in esophageal verrucous carcinoma. 61
30423307 2019
4
Verrucous carcinoma of the esophagus: A rare entity with a difficult diagnosis. 61
29452967 2018
5
Verrucous carcinoma of the esophagus-remains a diagnostic enigma. 61
29748561 2018
6
Verrucous Carcinoma of the Esophagus. 61
27803424 2016
7
VERRUCOUS CARCINOMA OF THE ESOPHAGUS INVOLVING THE ENTIRE ESOPHAGUS. 61
26734805 2015
8
Verrucous carcinoma of the esophagus: A case report and literature review. 61
25032204 2014
9
Verrucous carcinoma of the esophagus: a potential diagnostic dilemma. 61
24474899 2013
10
Verrucous carcinoma of the esophagus. 61
23039810 2012
11
Verrucous carcinoma of the esophagus: a rare variant of squamous cell carcinoma for which a preoperative diagnosis can be a difficult one to make. 61
22272545 2011
12
Verrucous carcinoma of the esophagus: a complex diagnosis. 61
20405383 2010
13
Verrucous carcinoma of the esophagus. 61
19555942 2009
14
[Verrucous carcinoma of the esophagus. A case report]. 61
15902055 2005
15
Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. 61
15229749 2004
16
[Verrucous carcinoma of the esophagus - a rare entity]. 61
15011117 2004
17
Verrucous carcinoma of the esophagus: clinicopathophysiologic features and treatment of a rare entity. 61
12757157 2003
18
Verrucous carcinoma of the esophagus. 61
11293774 2001
19
Verrucous carcinoma of the esophagus completely resected by endoscopy. 61
10763964 2000
20
Long-term survival in a patient with verrucous carcinoma of the esophagus. 61
8633546 1996
21
Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. 61
8030818 1994
22
Esophageal verrucous carcinoma: histologically a low-grade malignancy but clinically a fatal disease. 61
2007728 1991
23
Verrucous carcinoma of the esophagus. 61
3229394 1988
24
Verrucous acanthosis--so-called verrucous carcinoma--of the esophagus. 61
3564599 1987
25
Verrucous carcinoma of the esophagus. 61
6507406 1984
26
Endoscopic resection of squamous papilloma of the esophagus. 61
453131 1979
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Variations for Esophagus Verrucous Carcinoma

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Expression for Esophagus Verrucous Carcinoma

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Search GEO for disease gene expression data for Esophagus Verrucous Carcinoma.
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Pathways for Esophagus Verrucous Carcinoma

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Pathways related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.62 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
2
GPCR Pathway 63
Show member pathways
 13.49 TP53 MDM2 EGFR CDKN2A CCND1
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.83 TP53 MDM2 EGFR CCND1
4
Human cytomegalovirus infection 36
Show member pathways
 12.79 TP53 MDM2 EGFR CDKN2A CCND1
5
Gastric cancer 36
Show member pathways
 12.59 TP53 EGFR CDKN2A CDH1 CCND1
6
Pathways in cancer 36
12.57 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
7
Endometrial cancer 36
Show member pathways
 12.49 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
8
Mitotic G1-G1/S phases 65
Show member pathways
 12.47 TP53 MDM2 CDKN2A CCND1
9
DNA Damage 4
12.41 TP53 MDM2 CDKN2A CCND1
10
ErbB signaling pathway 36 1
Show member pathways
 12.39 TP53 MDM2 EGFR CCND1
11
MicroRNAs in cancer 36
12.35 TP53 MDM2 EGFR CDKN2A CCND1
12
Apoptosis Pathway 69
Show member pathways
 12.31 TP53 MDM2 EGFR
13
WNT Signaling 63
12.29 TP53 CDH1 CCND1
14
Endocytosis 36
12.28 MDM2 GIT2 EGFR
15
DNA Damage Response 1
Show member pathways
 12.28 TP53 MDM2 CDKN2A CCND1
16
Shigellosis 36
12.27 TP53 MDM2 EGFR
17
Development IGF-1 receptor signaling 23
Show member pathways
 12.26 TP53 MDM2 CCND1
18
VEGF Signaling 66
Show member pathways
 12.25 TP53 MDM2 EGFR CDH1
19
Glioma 36
Show member pathways
 12.23 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
20
Cyclins and Cell Cycle Regulation 63
Show member pathways
 12.22 TP53 CDKN2A CCND1
21
Human T-cell leukemia virus 1 infection 36
12.21 TP53 CDKN2A CCND1
22
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.21 TP53 MDM2 EGFR CCND1
23
Proteoglycans in cancer 36
12.19 TP53 MDM2 EGFR CCND1
24
Cell cycle 1 36
12.19 TP53 MDM2 CDKN2A CDH1 CCND1
25
Viral carcinogenesis 36
12.18 TP53 MDM2 CDKN2A CCND1
26
p53 Signaling 63
Show member pathways
 12.13 TP53 MDM2 CCND1
27
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.12 TP53 MDM2 EGFR CCND1
28
Colorectal Cancer Metastasis 63
12.07 TP53 EGFR CDH1 CCND1
29
Cellular senescence (KEGG) 36
12.03 TP53 MDM2 CDKN2A CCND1
30
FoxO signaling pathway 36
Show member pathways
 11.99 MDM2 EGFR CCND1
31
Direct p53 effectors 1
11.97 TP53 MDM2 EGFR
32
Thyroid hormone signaling pathway 36
11.93 TP53 MDM2 CCND1
33
Spinal Cord Injury 1
11.92 TP53 EGFR CCND1
34
Senescence and Autophagy in Cancer 1
11.86 TP53 MDM2 CDKN2A
35
DNA Damage Response (only ATM dependent) 1
11.84 TP53 MDM2 CDKN2A CCND1
36
Integrated Breast Cancer Pathway 1
11.84 TP53 MDM2 EGFR CDH1 CCND1
37
Androgen receptor signaling pathway 1
11.79 MDM2 EGFR CCND1
38
Retinoblastoma (RB) in Cancer 1
11.78 TP53 MDM2 CCND1
39
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.69 TP53 MDM2 CDKN2A
40
Platinum drug resistance 36
11.68 TP53 MDM2 CDKN2A
41
Transcription_P53 signaling pathway 23
11.59 TP53 MDM2 CDKN2A
42
HIF1Alpha Pathway 63
11.53 TP53 MDM2 CDKN2A
43
Copper homeostasis 1
11.53 TP53 MDM2 CCND1
44
DNA damage_ATM/ATR regulation of G1/S checkpoint 23
11.42 TP53 MDM2 CCND1
45
Photodynamic therapy-induced AP-1 survival signaling. 1
11.41 TP53 EGFR CDKN2A CCND1
46
Glioblastoma Multiforme 63
11.4 TP53 MDM2 EGFR CDKN2A CCND1
47
Integrated Cancer Pathway 1
11.39 TP53 MDM2
48
Stabilization and expansion of the E-cadherin adherens junction 1
11.32 EGFR CDH1
49
Oncogene Induced Senescence 65
11.24 TP53 MDM2 CDKN2A
50
Gastric Cancer Network 2 1
11.23 TP53 EGFR
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GO Terms for Esophagus Verrucous Carcinoma

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Cellular components related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.13 TP53 MDM2 CDKN2A
2 protein-containing complex GO:0032991 8.92 TP53 MDM2 EGFR CDKN2A

Biological processes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.85 TP53 EGFR CDKN2A CDH1
2 protein destabilization GO:0031648 9.63 MDM2 CDKN2A
3 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.62 EGFR CCND1
4 positive regulation of cell cycle GO:0045787 9.62 MDM2 CCND1
5 negative regulation of mitotic cell cycle GO:0045930 9.61 TP53 EGFR
6 liver regeneration GO:0097421 9.61 EGFR CCND1
7 positive regulation of cell cycle arrest GO:0071158 9.6 TP53 CDKN2A
8 response to steroid hormone GO:0048545 9.59 MDM2 CCND1
9 response to antibiotic GO:0046677 9.58 TP53 MDM2
10 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.58 EGFR CCND1
11 cellular response to gamma radiation GO:0071480 9.57 TP53 MDM2
12 cellular response to organic substance GO:0071310 9.56 MDM2 CCND1
13 negative regulation of cell cycle arrest GO:0071157 9.54 MDM2 CCND1
14 positive regulation of protein export from nucleus GO:0046827 9.52 TP53 MDM2
15 response to X-ray GO:0010165 9.51 TP53 CCND1
16 response to iron ion GO:0010039 9.49 MDM2 CCND1
17 replicative senescence GO:0090399 9.48 TP53 CDKN2A
18 cardiac septum morphogenesis GO:0060411 9.46 TP53 MDM2
19 response to drug GO:0042493 9.46 TP53 MDM2 CDH1 CCND1
20 response to magnesium ion GO:0032026 9.43 MDM2 CCND1
21 amyloid fibril formation GO:1990000 9.4 MDM2 CDKN2A
22 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.37 TP53 EGFR
23 mitotic G1 DNA damage checkpoint GO:0031571 9.32 TP53 CCND1
24 cellular response to UV-C GO:0071494 9.26 TP53 MDM2
25 cellular response to actinomycin D GO:0072717 8.96 TP53 MDM2
26 response to UV-A GO:0070141 8.62 EGFR CCND1

Molecular functions related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.71 GIT2 EGFR CDKN2A CCND1
2 protein kinase binding GO:0019901 9.62 TP53 EGFR CDKN2A CCND1
3 ubiquitin protein ligase binding GO:0031625 9.61 TP53 MDM2 EGFR
4 enzyme binding GO:0019899 9.46 TP53 MDM2 EGFR CCND1
5 SUMO transferase activity GO:0019789 9.37 MDM2 CDKN2A
6 MDM2/MDM4 family protein binding GO:0097371 9.26 TP53 CDKN2A
7 p53 binding GO:0002039 9.13 TP53 MDM2 CDKN2A
8 disordered domain specific binding GO:0097718 8.8 TP53 MDM2 CDKN2A
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Sources for Esophagus Verrucous Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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