MCID: ESP011
MIFTS: 32

Esophagus Verrucous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Esophagus Verrucous Carcinoma

MalaCards integrated aliases for Esophagus Verrucous Carcinoma:

Name: Esophagus Verrucous Carcinoma 11 14
Verrucous Carcinoma of the Esophagus 11
Verrucous Carcinoma of Oesophagus 11
Verrucous Carcinoma of Esophagus 11
Oesophagus Verrucous Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3747
NCIt 49 C27420
UMLS 71 C1333470

Summaries for Esophagus Verrucous Carcinoma

MalaCards based summary: Esophagus Verrucous Carcinoma, also known as verrucous carcinoma of the esophagus, is related to barrett esophagus and keratoacanthoma. An important gene associated with Esophagus Verrucous Carcinoma is GIT2 (GIT ArfGAP 2), and among its related pathways/superpathways are ERK Signaling and Disease. Related phenotypes are Decreased viability and Increased shRNA abundance (Z-score > 2)

Related Diseases for Esophagus Verrucous Carcinoma

Diseases related to Esophagus Verrucous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 barrett esophagus 30.0 TP53 CDKN2A CCND1
2 keratoacanthoma 29.6 TP53 PIK3CA EGFR CDH1
3 papilloma 29.3 TP53 EGFR CDKN2A CDH1 CCND1
4 gastroesophageal reflux 29.3 TP53 MDM2 EGFR CCND1
5 verrucous carcinoma 29.2 TP53 PIK3CA EGFR CDKN2A CDH1
6 esophageal cancer 28.7 TP53 PIK3CA MDM2 EGFR CDKN2A CDH1
7 squamous cell carcinoma 28.5 TP53 PIK3CA MDM2 EGFR CDKN2A CDH1
8 esophagitis 10.3
9 esophageal candidiasis 10.3
10 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.2 TP53 CDKN2A
11 endometrial squamous cell carcinoma 10.2 TP53 CDKN2A
12 bizarre leiomyoma 10.2 TP53 CDKN2A
13 squamous cell papilloma 10.2 TP53 CDKN2A
14 larynx squamous papilloma 10.2 TP53 CDKN2A
15 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
16 conjunctival squamous cell carcinoma 10.2 TP53 CDKN2A
17 bladder clear cell adenocarcinoma 10.2 TP53 CDKN2A
18 penis basal cell carcinoma 10.2 CDKN2A CDH1
19 atypical neurofibroma 10.2 TP53 CDKN2A
20 lip cancer 10.2 TP53 CDKN2A
21 male urethral cancer 10.2 TP53 CDKN2A
22 chronic cervicitis 10.2 TP53 CDKN2A
23 basaloid squamous cell carcinoma 10.2 TP53 CDKN2A
24 male reproductive organ benign neoplasm 10.2 TP53 CDKN2A
25 paranasal sinus cancer 10.2 TP53 CDKN2A
26 pleomorphic xanthoastrocytoma 10.1 TP53 CDKN2A
27 malignant spindle cell melanoma 10.1 TP53 CDKN2A
28 adenoid squamous cell carcinoma 10.1 TP53 CDH1
29 borst-jadassohn intraepidermal carcinoma 10.1 TP53 CDKN2A
30 phimosis 10.1 TP53 CDKN2A
31 uterus carcinoma in situ 10.1 TP53 CDKN2A
32 barrett's adenocarcinoma 10.1 TP53 CDKN2A
33 conjunctival cancer 10.1 TP53 CDKN2A
34 neurofibrosarcoma 10.1 TP53 CDKN2A
35 tonsil squamous cell carcinoma 10.1 CDKN2A CCND1
36 cervix uteri carcinoma in situ 10.1 TP53 CDKN2A
37 pancreatic foamy gland adenocarcinoma 10.1 TP53 CCND1
38 esophagitis, eosinophilic, 1 10.1
39 fungal infectious disease 10.1
40 eosinophilic gastroenteritis 10.1
41 esophageal disease 10.1
42 achalasia 10.1
43 rare tumor 10.1
44 vaginal carcinosarcoma 10.1 TP53 PIK3CA
45 cerebrovascular benign neoplasm 10.1 TP53 CDH1
46 esophageal adenosquamous carcinoma 10.1 TP53 CDH1
47 peritoneal mesothelioma 10.1 TP53 CDKN2A
48 pulmonary sclerosing hemangioma 10.1 TP53 CDH1
49 anus basaloid carcinoma 10.1 PIK3CA CDKN2A
50 tonsillar pillar cancer 10.1 EGFR CDKN2A

Graphical network of the top 20 diseases related to Esophagus Verrucous Carcinoma:



Diseases related to Esophagus Verrucous Carcinoma

Symptoms & Phenotypes for Esophagus Verrucous Carcinoma

GenomeRNAi Phenotypes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

25 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.86 EGFR PIK3CA
2 Decreased viability GR00055-A-2 9.86 EGFR PIK3CA
3 Decreased viability GR00221-A-1 9.86 CDH1 CDKN2A EGFR PIK3CA
4 Decreased viability GR00221-A-2 9.86 PIK3CA
5 Decreased viability GR00221-A-3 9.86 CDKN2A
6 Decreased viability GR00221-A-4 9.86 CDKN2A EGFR PIK3CA
7 Decreased viability GR00301-A 9.86 CDH1
8 Decreased viability GR00402-S-2 9.86 CDH1 PIK3CA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.58 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.58 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.58 EGFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.58 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.58 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.58 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.58 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.58 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.58 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 EGFR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.58 TP53
21 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.58 TP53
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.58 PIK3CA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.58 TP53
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.58 EGFR
26 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.58 EGFR

MGI Mouse Phenotypes related to Esophagus Verrucous Carcinoma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.08 CCND1 CDH1 CDKN2A EGFR MDM2 PIK3CA
2 endocrine/exocrine gland MP:0005379 10.02 CCND1 CDH1 CDKN2A EGFR MDM2 PIK3CA
3 cellular MP:0005384 10.01 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2
4 normal MP:0002873 10 CCND1 CDH1 EGFR GIT2 MDM2 TP53
5 no phenotypic analysis MP:0003012 9.99 CDH1 CDKN2A EGFR MDM2 PIK3CA TP53
6 digestive/alimentary MP:0005381 9.98 CCND1 CDH1 CDKN2A EGFR MDM2 PIK3CA
7 embryo MP:0005380 9.93 CDH1 CDKN2A EGFR MDM2 PIK3CA TP53
8 immune system MP:0005387 9.92 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2
9 cardiovascular system MP:0005385 9.91 CCND1 CDH1 CDKN2A EGFR MDM2 PIK3CA
10 muscle MP:0005369 9.89 CDKN2A EGFR MDM2 PIK3CA TP53
11 pigmentation MP:0001186 9.85 CDKN2A EGFR MDM2 TP53
12 reproductive system MP:0005389 9.7 CCND1 CDH1 CDKN2A EGFR MDM2 PIK3CA
13 respiratory system MP:0005388 9.65 CCND1 CDKN2A EGFR GIT2 TP53
14 skeleton MP:0005390 9.43 CCND1 CDKN2A EGFR MDM2 PIK3CA TP53
15 integument MP:0010771 9.23 CCND1 CDH1 CDKN2A EGFR GIT2 MDM2

Drugs & Therapeutics for Esophagus Verrucous Carcinoma

Search Clinical Trials, NIH Clinical Center for Esophagus Verrucous Carcinoma

Genetic Tests for Esophagus Verrucous Carcinoma

Anatomical Context for Esophagus Verrucous Carcinoma

Publications for Esophagus Verrucous Carcinoma

Articles related to Esophagus Verrucous Carcinoma:

(show all 28)
# Title Authors PMID Year
1
Verrucous carcinoma of the esophagus with complete response after chemoradiotherapy. 62
35781764 2022
2
Whitish elevated lesion in the oesophagus: verrucous carcinoma. 62
34119042 2021
3
Verrucous carcinoma of the esophagus - a case report and literature review. 62
33036050 2020
4
Verrucous carcinoma of the esophagus: a case report and literature review. 62
32030515 2020
5
Human papillomavirus infection is not involved in esophageal verrucous carcinoma. 62
30423307 2019
6
Verrucous carcinoma of the esophagus: A rare entity with a difficult diagnosis. 62
29452967 2018
7
Verrucous carcinoma of the esophagus-remains a diagnostic enigma. 62
29748561 2018
8
Verrucous Carcinoma of the Esophagus. 62
27803424 2016
9
VERRUCOUS CARCINOMA OF THE ESOPHAGUS INVOLVING THE ENTIRE ESOPHAGUS. 62
26734805 2015
10
Verrucous carcinoma of the esophagus: A case report and literature review. 62
25032204 2014
11
Verrucous carcinoma of the esophagus: a potential diagnostic dilemma. 62
24474899 2013
12
Verrucous carcinoma of the esophagus. 62
23039810 2012
13
Verrucous carcinoma of the esophagus: a rare variant of squamous cell carcinoma for which a preoperative diagnosis can be a difficult one to make. 62
22272545 2011
14
Verrucous carcinoma of the esophagus: a complex diagnosis. 62
20405383 2010
15
Verrucous carcinoma of the esophagus. 62
19555942 2009
16
[Verrucous carcinoma of the esophagus. A case report]. 62
15902055 2005
17
Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. 62
15229749 2004
18
[Verrucous carcinoma of the esophagus - a rare entity]. 62
15011117 2004
19
Verrucous carcinoma of the esophagus: clinicopathophysiologic features and treatment of a rare entity. 62
12757157 2003
20
Verrucous carcinoma of the esophagus. 62
11293774 2001
21
Verrucous carcinoma of the esophagus completely resected by endoscopy. 62
10763964 2000
22
Long-term survival in a patient with verrucous carcinoma of the esophagus. 62
8633546 1996
23
Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. 62
8030818 1994
24
Esophageal verrucous carcinoma: histologically a low-grade malignancy but clinically a fatal disease. 62
2007728 1991
25
Verrucous carcinoma of the esophagus. 62
3229394 1988
26
Verrucous acanthosis--so-called verrucous carcinoma--of the esophagus. 62
3564599 1987
27
Verrucous carcinoma of the esophagus. 62
6507406 1984
28
Endoscopic resection of squamous papilloma of the esophagus. 62
453131 1979

Variations for Esophagus Verrucous Carcinoma

Expression for Esophagus Verrucous Carcinoma

Search GEO for disease gene expression data for Esophagus Verrucous Carcinoma.

Pathways for Esophagus Verrucous Carcinoma

Pathways related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TP53 MDM2 EGFR CDKN2A CDH1 CCND1
2
Show member pathways
13.62 TP53 PIK3CA MDM2 EGFR CDKN2A CDH1
3 13.59 TP53 PIK3CA MDM2 GIT2 EGFR CDH1
4
Show member pathways
13.33 TP53 PIK3CA MDM2 EGFR CDKN2A CCND1
5
Show member pathways
12.94 TP53 PIK3CA MDM2 EGFR
6
Show member pathways
12.82 CCND1 EGFR MDM2 PIK3CA TP53
7
Show member pathways
12.81 TP53 PIK3CA MDM2 EGFR CDKN2A
8 12.44 TP53 MDM2 CDKN2A CCND1
9
Show member pathways
12.39 CCND1 CDH1 PIK3CA TP53
10
Show member pathways
12.36 TP53 PIK3CA MDM2 EGFR
11 12.33 TP53 CDH1 CCND1
12
Show member pathways
12.32 TP53 PIK3CA MDM2 EGFR CDH1
13
Show member pathways
12.32 TP53 PIK3CA MDM2 EGFR CDKN2A CDH1
14
Show member pathways
12.31 PIK3CA EGFR CCND1
15
Show member pathways
12.29 TP53 PIK3CA MDM2 EGFR CCND1
16
Show member pathways
12.23 PIK3CA EGFR CCND1
17 12.2 PIK3CA EGFR CCND1
18
Show member pathways
12.17 PIK3CA EGFR CCND1
19
Show member pathways
12.17 TP53 PIK3CA MDM2 CCND1
20
Show member pathways
12.15 TP53 MDM2 CDKN2A CCND1
21
Show member pathways
12.13 TP53 MDM2 CCND1
22 12.11 TP53 PIK3CA MDM2 EGFR CDKN2A CDH1
23 12.1 TP53 PIK3CA CDH1
24 12.09 TP53 EGFR CDH1 CCND1
25
Show member pathways
12.06 TP53 PIK3CA MDM2 EGFR CCND1
26
Show member pathways
12.04 CCND1 CDKN2A TP53
27
Show member pathways
12.04 CCND1 MDM2 TP53
28
Show member pathways
12.04 TP53 PIK3CA CDKN2A CCND1
29
Show member pathways
12.01 PIK3CA MDM2 EGFR
30
Show member pathways
12.01 CCND1 EGFR MDM2 PIK3CA
31
Show member pathways
12 TP53 CDKN2A CCND1
32 11.99 TP53 MDM2 EGFR
33
Show member pathways
11.96 TP53 PIK3CA EGFR
34 11.95 CCND1 CDH1 EGFR MDM2 TP53
35 11.93 TP53 EGFR CCND1
36 11.89 TP53 MDM2 CDKN2A
37
Show member pathways
11.85 TP53 MDM2 CDKN2A
38 11.84 CCND1 PIK3CA TP53
39 11.8 TP53 PIK3CA MDM2 CCND1
40 11.79 TP53 MDM2 CCND1
41 11.77 TP53 PIK3CA MDM2
42 11.77 PIK3CA EGFR CDKN2A CDH1 CCND1
43
Show member pathways
11.73 TP53 MDM2 CDKN2A
44 11.71 CDKN2A CDH1 CCND1
45 11.68 TP53 CDKN2A CCND1
46 11.64 TP53 MDM2 CDKN2A
47 11.6 TP53 CDKN2A CCND1
48
Show member pathways
11.57 PIK3CA EGFR CCND1
49 11.55 PIK3CA GIT2 CCND1
50 11.54 TP53 MDM2 CDKN2A

GO Terms for Esophagus Verrucous Carcinoma

Cellular components related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription repressor complex GO:0017053 9.1 TP53 MDM2 CCND1

Biological processes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.83 PIK3CA GIT2 EGFR CDKN2A
2 regulation of cell cycle GO:0051726 9.8 TP53 MDM2 CDKN2A CCND1
3 response to X-ray GO:0010165 9.78 TP53 CCND1
4 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.76 TP53 MDM2
5 replicative senescence GO:0090399 9.71 TP53 CDKN2A
6 cardiac septum morphogenesis GO:0060411 9.67 TP53 MDM2
7 mitotic G1 DNA damage checkpoint signaling GO:0031571 9.62 CCND1 TP53
8 cellular response to actinomycin D GO:0072717 9.26 TP53 MDM2
9 positive regulation of miRNA maturation GO:1903800 9.16 TP53 EGFR
10 response to UV-A GO:0070141 8.92 EGFR CCND1

Molecular functions related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.76 TP53 MDM2 EGFR CCND1
2 SUMO transferase activity GO:0019789 9.43 MDM2 CDKN2A
3 disordered domain specific binding GO:0097718 9.35 TP53 MDM2 CDKN2A
4 kinase activity GO:0016301 9.1 PIK3CA GIT2 EGFR CDKN2A CCND1

Sources for Esophagus Verrucous Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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