Esophagus Verrucous Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ESP011 MIFTS: 36	Esophagus Verrucous Carcinoma Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Esophagus Verrucous Carcinoma

MalaCards integrated aliases for Esophagus Verrucous Carcinoma:

Name: Esophagus Verrucous Carcinoma ¹² ¹⁵

Verrucous Carcinoma of the Esophagus ¹²

Verrucous Carcinoma of Esophagus ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3747

NCIt ⁵¹ C27420

UMLS ⁷⁴ C1333470

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Summaries for Esophagus Verrucous Carcinoma

MalaCards based summary : Esophagus Verrucous Carcinoma, also known as verrucous carcinoma of the esophagus, is related to verrucous carcinoma and squamous cell carcinoma. An important gene associated with Esophagus Verrucous Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and Human cytomegalovirus infection. The drug Antioxidants has been mentioned in the context of this disorder. Affiliated tissues include breast, lung and tongue, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Esophagus Verrucous Carcinoma

Diseases related to Esophagus Verrucous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)

#	Related Disease	Score	Top Affiliating Genes
1	verrucous carcinoma	30.5	CCND1 CDKN2A
2	squamous cell carcinoma	29.0	CCND1 CDH1 CDKN2A EGFR
3	malignant peritoneal mesothelioma	10.1	CDKN2A EGFR
4	peritoneal mesothelioma	10.1	CDKN2A EGFR
5	anaplastic oligodendroglioma	10.1	CDKN2A EGFR
6	oligodendroglioma	10.1	CDKN2A EGFR
7	basaloid squamous cell carcinoma	10.1	CDKN2A EGFR
8	cervical adenosquamous carcinoma	10.1	CDKN2A EGFR
9	vulva cancer	10.1	CDKN2A EGFR
10	mucinous adenocarcinoma	10.1	CDKN2A EGFR
11	supratentorial cancer	10.1	CDKN2A EGFR
12	cerebrum cancer	10.1	CDKN2A EGFR
13	small cell carcinoma	10.1	CDKN2A EGFR
14	grade iii astrocytoma	10.0	CDKN2A EGFR
15	inflammatory breast carcinoma	10.0	CDH1 EGFR
16	central nervous system cancer	10.0	CDKN2A EGFR
17	lipid-rich carcinoma	10.0	CDH1 EGFR
18	tongue disease	10.0	CDH1 CDKN2A
19	tonsil cancer	10.0	CDH1 CDKN2A
20	salivary gland carcinoma	10.0	CDKN2A EGFR
21	endometrial adenocarcinoma	10.0	CDKN2A EGFR
22	bronchiolo-alveolar adenocarcinoma	10.0	CDH1 EGFR
23	epstein-barr virus-associated gastric carcinoma	10.0	CDH1 CDKN2A
24	malignant peripheral nerve sheath tumor	10.0	CDKN2A EGFR
25	li-fraumeni syndrome	10.0	CDKN2A EGFR
26	cholecystitis	10.0	CDH1 CDKN2A
27	cervical squamous cell carcinoma	10.0	CDH1 CDKN2A
28	colorectal adenocarcinoma	10.0	CDH1 EGFR
29	intrahepatic cholangiocarcinoma	10.0	CDH1 EGFR
30	breast papillomatosis	10.0	CCND1 CDKN2A
31	papilloma	10.0	CCND1 CDKN2A
32	tonsil squamous cell carcinoma	9.9	CCND1 CDKN2A
33	bowenoid papulosis	9.9	CCND1 CDKN2A
34	skin carcinoma in situ	9.9	CCND1 CDKN2A
35	uterine carcinosarcoma	9.9	CDH1 EGFR
36	endometrial squamous cell carcinoma	9.9	CCND1 CDKN2A
37	oral leukoplakia	9.9	CCND1 CDKN2A
38	ischemic fasciitis	9.9	CCND1 CDKN2A
39	male reproductive system disease	9.9	CCND1 CDH1
40	hidradenocarcinoma	9.9	CCND1 EGFR
41	oral cavity cancer	9.9	CDH1 EGFR
42	chondromyxoid fibroma	9.9	CCND1 CDKN2A
43	inverted papilloma	9.9	CCND1 CDKN2A
44	tongue squamous cell carcinoma	9.9	CDH1 CDKN2A
45	retinal cancer	9.9	CCND1 CDKN2A
46	respiratory system disease	9.9	CDH1 EGFR
47	estrogen-receptor positive breast cancer	9.9	CCND1 EGFR
48	small cell cancer of the lung	9.9	CDKN2A EGFR
49	ocular cancer	9.9	CCND1 CDKN2A
50	meningioma, familial	9.9	CDH1 CDKN2A

Graphical network of the top 20 diseases related to Esophagus Verrucous Carcinoma:

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Symptoms & Phenotypes for Esophagus Verrucous Carcinoma

GenomeRNAi Phenotypes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

²⁷ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.7	EGFR
2	Decreased viability	GR00221-A-1	9.7	CDH1 CDKN2A EGFR
3	Decreased viability	GR00221-A-3	9.7	CDKN2A
4	Decreased viability	GR00221-A-4	9.7	CDKN2A EGFR
5	Decreased viability	GR00301-A	9.7	CDH1
6	Decreased viability	GR00402-S-2	9.7	CDH1 CDKN2A EGFR
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.55	EGFR
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.55	EGFR
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.55	CCND1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.55	CCND1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.55	CCND1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.55	CCND1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.55	CCND1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.55	EGFR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.55	CCND1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.55	CCND1 EGFR
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	9.55	CCND1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.55	EGFR
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.55	CCND1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	9.55	CCND1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.55	EGFR
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.55	EGFR

MGI Mouse Phenotypes related to Esophagus Verrucous Carcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.67	CCND1 CDH1 CDKN2A EGFR
2	digestive/alimentary	MP:0005381	9.62	CCND1 CDH1 CDKN2A EGFR
3	endocrine/exocrine gland	MP:0005379	9.56	CCND1 CDH1 CDKN2A EGFR
4	integument	MP:0010771	9.46	CCND1 CDH1 CDKN2A EGFR
5	neoplasm	MP:0002006	9.26	CCND1 CDH1 CDKN2A EGFR
6	reproductive system	MP:0005389	8.92	CCND1 CDH1 CDKN2A EGFR

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Drugs & Therapeutics for Esophagus Verrucous Carcinoma

Drugs for Esophagus Verrucous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Antioxidants		Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of VIUSID® Plus GLIZIGEN® in Patients With Papilloma Virus Esophageal	Completed	NCT03584308	Phase 2

Search NIH Clinical Center for Esophagus Verrucous Carcinoma

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Genetic Tests for Esophagus Verrucous Carcinoma

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Anatomical Context for Esophagus Verrucous Carcinoma

MalaCards organs/tissues related to Esophagus Verrucous Carcinoma:

⁴²

Breast, Lung, Tongue, Tonsil, Kidney, Colon, Bone

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Publications for Esophagus Verrucous Carcinoma

Articles related to Esophagus Verrucous Carcinoma:

(show all 19)

#	Title	Authors	Year
1	Verrucous carcinoma of the esophagus: A rare entity with a difficult diagnosis. ( 29452967 )	Paseiro Crespo G...Gimeno Aranguez M	2018
2	Verrucous carcinoma of the esophagus-remains a diagnostic enigma. ( 29748561 )	Al-Shoha M...Tharian B	2018
3	Verrucous Carcinoma of the Esophagus. ( 27803424 )	Ogawa R...Sakaida I	2016
4	VERRUCOUS CARCINOMA OF THE ESOPHAGUS INVOLVING THE ENTIRE ESOPHAGUS. ( 26734805 )	Brandalise A...Brandalise NA	2015
5	Verrucous carcinoma of the esophagus: A case report and literature review. ( 25032204 )	Ramani C...Nathan RS	2014
6	Verrucous carcinoma of the esophagus: a potential diagnostic dilemma. ( 24474899 )	Ahmed K...Atiq M	2013
7	Verrucous carcinoma of the esophagus. ( 23039810 )	Lagos AC...Neves BC	2012
8	Verrucous carcinoma of the esophagus: a rare variant of squamous cell carcinoma for which a preoperative diagnosis can be a difficult one to make. ( 22272545 )	Chu Q...Hobley J	2011
9	Verrucous carcinoma of the esophagus: a complex diagnosis. ( 20405383 )	Macias-Garcia F...Dominguez-Munoz JE	2010
10	Verrucous carcinoma of the esophagus. ( 19555942 )	Na S...Kim JH	2009
11	Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. ( 15229749 )	Devlin S...Romagnuolo J	2004
12	Verrucous carcinoma of the esophagus: clinicopathophysiologic features and treatment of a rare entity. ( 12757157 )	Osborn NK...Nguyen CC	2003
13	Verrucous carcinoma of the esophagus. ( 11293774 )	Ere?o C...Bilbao FJ	2001
14	Verrucous carcinoma of the esophagus completely resected by endoscopy. ( 10763964 )	Tajiri H...Kawahara H	2000
15	Long-term survival in a patient with verrucous carcinoma of the esophagus. ( 8633546 )	Malik AB...McCully KS	1996
16	Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. ( 8030818 )	Garrard CL...Sawyers JL	1994
17	Verrucous carcinoma of the esophagus. ( 3229394 )	Koerfgen HP...Hohenberger W	1988
18	Verrucous acanthosis--so-called verrucous carcinoma--of the esophagus. ( 3564599 )	Barbier PA...Ruchti C	1987
19	Verrucous carcinoma of the esophagus. ( 6507406 )	Agha FP...Sams JS	1984

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Genes for Esophagus Verrucous Carcinoma

Genes related to Esophagus Verrucous Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.6	DISEASES inferred ¹⁵
2	CDH1	Cadherin 1	Protein Coding	13.57	DISEASES inferred ¹⁵
3	CCND1	Cyclin D1	Protein Coding	13.51	DISEASES inferred ¹⁵
4	EGFR	Epidermal Growth Factor Receptor	Protein Coding	13.3	DISEASES inferred ¹⁵

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Variations for Esophagus Verrucous Carcinoma

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Expression for Esophagus Verrucous Carcinoma

Search GEO for disease gene expression data for Esophagus Verrucous Carcinoma.

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Pathways for Esophagus Verrucous Carcinoma

Pathways related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁵ Show member pathways ILK Signaling ⁶⁵ MAPK Signaling ⁶⁵ Molecular Mechanisms of Cancer ⁶⁵ Rho Family GTPases ⁶⁵	13.42	CCND1 CDH1 CDKN2A EGFR
2	Human cytomegalovirus infection ³⁸ Show member pathways Human immunodeficiency virus 1 infection ³⁸ Kaposi sarcoma-associated herpesvirus infection ³⁸	12.58	CCND1 CDKN2A EGFR
3	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.41	CCND1 CDH1 CDKN2A EGFR
4	Pathways in cancer ³⁸	12.35	CCND1 CDH1 CDKN2A EGFR
5	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.19	CCND1 CDH1 EGFR
6	MicroRNAs in cancer ³⁸	12.16	CCND1 CDKN2A EGFR
7	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.15	CCND1 CDH1 CDKN2A EGFR
8	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.12	CCND1 CDH1 CDKN2A EGFR
9	Cell cycle ³⁸ ¹	12.01	CCND1 CDH1 CDKN2A
10	Colorectal Cancer Metastasis ⁶⁵	11.85	CCND1 CDH1 EGFR
11	Integrated Breast Cancer Pathway ¹	11.8	CCND1 CDH1 EGFR
12	FoxO signaling pathway ³⁸ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.78	CCND1 EGFR
13	Apelin signaling pathway ³⁸	11.77	CCND1 CDH1
14	Signaling by PTK6 ⁶⁷ Show member pathways PTK6 Activates STAT3 ⁶⁷ PTK6 Down-Regulation ⁶⁷ PTK6 Expression ⁶⁷ PTK6 promotes HIF1A stabilization ⁶⁷ PTK6 Regulates Proteins Involved in RNA Processing ⁶⁷ PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ⁶⁷ PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ⁶⁷ RAS signaling downstream of NF1 loss-of-function variants ⁶⁷	11.75	CCND1 EGFR
15	Spinal Cord Injury ¹	11.71	CCND1 EGFR
16	DNA Damage Response (only ATM dependent) ¹	11.68	CCND1 CDKN2A
17	Glioblastoma Multiforme ⁶⁵	11.63	CCND1 CDKN2A EGFR
18	Listeria monocytogenes entry into host cells ⁶⁷ Show member pathways E-cadherin signaling events ¹ EGFR downregulation ⁶⁷ InlA-mediated entry of Listeria monocytogenes into host cells ⁶⁷ InlB-mediated entry of Listeria monocytogenes into host cell ⁶⁷ Negative regulation of MET activity ⁶⁷	11.57	CDH1 EGFR
19	Androgen receptor signaling pathway ¹	11.56	CCND1 EGFR
20	Regulation of Wnt-mediated beta catenin signaling and target gene transcription ¹	11.49	CCND1 CDH1
21	Adherens junction ³⁸	11.44	CDH1 EGFR
22	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	11.42	CCND1 EGFR
23	Regulation of Telomerase ¹	11.39	CCND1 EGFR
24	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁵ Show member pathways TOB in T-Cell Signaling ⁶⁵	11.31	CCND1 EGFR
25	Stabilization and expansion of the E-cadherin adherens junction ¹	11.16	CDH1 EGFR
26	E-cadherin signaling in the nascent adherens junction ¹	11.07	CCND1 CDH1
27	a6b1 and a6b4 Integrin signaling ¹	11.03	CDH1 EGFR
28	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.84	CCND1 CDKN2A EGFR
29	Bladder cancer ¹ ³⁸	10.79	CCND1 CDH1 CDKN2A EGFR
30	E-cadherin signaling in keratinocytes ¹	10.77	CDH1 EGFR

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GO Terms for Esophagus Verrucous Carcinoma

Biological processes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to organic cyclic compound	GO:0014070	9.46	CCND1 EGFR
2	response to estradiol	GO:0032355	9.43	CCND1 EGFR
3	positive regulation of transcription, DNA-templated	GO:0045893	9.43	CDH1 CDKN2A EGFR
4	G1/S transition of mitotic cell cycle	GO:0000082	9.4	CCND1 CDKN2A
5	response to organic substance	GO:0010033	9.37	CCND1 CDH1
6	liver development	GO:0001889	9.32	CCND1 EGFR
7	response to calcium ion	GO:0051592	9.16	CCND1 EGFR
8	liver regeneration	GO:0097421	8.96	CCND1 EGFR
9	response to UV-A	GO:0070141	8.62	CCND1 EGFR

Molecular functions related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	8.8	CCND1 CDKN2A EGFR

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Sources for Esophagus Verrucous Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia