MCID: ESP011
MIFTS: 36

Esophagus Verrucous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophagus Verrucous Carcinoma

MalaCards integrated aliases for Esophagus Verrucous Carcinoma:

Name: Esophagus Verrucous Carcinoma 12 15
Verrucous Carcinoma of the Esophagus 12
Verrucous Carcinoma of Esophagus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3747
NCIt 51 C27420
UMLS 74 C1333470

Summaries for Esophagus Verrucous Carcinoma

MalaCards based summary : Esophagus Verrucous Carcinoma, also known as verrucous carcinoma of the esophagus, is related to verrucous carcinoma and squamous cell carcinoma. An important gene associated with Esophagus Verrucous Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and Human cytomegalovirus infection. The drug Antioxidants has been mentioned in the context of this disorder. Affiliated tissues include breast, lung and tongue, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Esophagus Verrucous Carcinoma

Diseases related to Esophagus Verrucous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 112, show less)
# Related Disease Score Top Affiliating Genes
1 verrucous carcinoma 30.5 CCND1 CDKN2A
2 squamous cell carcinoma 29.0 CCND1 CDH1 CDKN2A EGFR
3 malignant peritoneal mesothelioma 10.1 CDKN2A EGFR
4 peritoneal mesothelioma 10.1 CDKN2A EGFR
5 anaplastic oligodendroglioma 10.1 CDKN2A EGFR
6 oligodendroglioma 10.1 CDKN2A EGFR
7 basaloid squamous cell carcinoma 10.1 CDKN2A EGFR
8 cervical adenosquamous carcinoma 10.1 CDKN2A EGFR
9 vulva cancer 10.1 CDKN2A EGFR
10 mucinous adenocarcinoma 10.1 CDKN2A EGFR
11 supratentorial cancer 10.1 CDKN2A EGFR
12 cerebrum cancer 10.1 CDKN2A EGFR
13 small cell carcinoma 10.1 CDKN2A EGFR
14 grade iii astrocytoma 10.0 CDKN2A EGFR
15 inflammatory breast carcinoma 10.0 CDH1 EGFR
16 central nervous system cancer 10.0 CDKN2A EGFR
17 lipid-rich carcinoma 10.0 CDH1 EGFR
18 tongue disease 10.0 CDH1 CDKN2A
19 tonsil cancer 10.0 CDH1 CDKN2A
20 salivary gland carcinoma 10.0 CDKN2A EGFR
21 endometrial adenocarcinoma 10.0 CDKN2A EGFR
22 bronchiolo-alveolar adenocarcinoma 10.0 CDH1 EGFR
23 epstein-barr virus-associated gastric carcinoma 10.0 CDH1 CDKN2A
24 malignant peripheral nerve sheath tumor 10.0 CDKN2A EGFR
25 li-fraumeni syndrome 10.0 CDKN2A EGFR
26 cholecystitis 10.0 CDH1 CDKN2A
27 cervical squamous cell carcinoma 10.0 CDH1 CDKN2A
28 colorectal adenocarcinoma 10.0 CDH1 EGFR
29 intrahepatic cholangiocarcinoma 10.0 CDH1 EGFR
30 breast papillomatosis 10.0 CCND1 CDKN2A
31 papilloma 10.0 CCND1 CDKN2A
32 tonsil squamous cell carcinoma 9.9 CCND1 CDKN2A
33 bowenoid papulosis 9.9 CCND1 CDKN2A
34 skin carcinoma in situ 9.9 CCND1 CDKN2A
35 uterine carcinosarcoma 9.9 CDH1 EGFR
36 endometrial squamous cell carcinoma 9.9 CCND1 CDKN2A
37 oral leukoplakia 9.9 CCND1 CDKN2A
38 ischemic fasciitis 9.9 CCND1 CDKN2A
39 male reproductive system disease 9.9 CCND1 CDH1
40 hidradenocarcinoma 9.9 CCND1 EGFR
41 oral cavity cancer 9.9 CDH1 EGFR
42 chondromyxoid fibroma 9.9 CCND1 CDKN2A
43 inverted papilloma 9.9 CCND1 CDKN2A
44 tongue squamous cell carcinoma 9.9 CDH1 CDKN2A
45 retinal cancer 9.9 CCND1 CDKN2A
46 respiratory system disease 9.9 CDH1 EGFR
47 estrogen-receptor positive breast cancer 9.9 CCND1 EGFR
48 small cell cancer of the lung 9.9 CDKN2A EGFR
49 ocular cancer 9.9 CCND1 CDKN2A
50 meningioma, familial 9.9 CDH1 CDKN2A
51 bile duct cancer 9.8 CCND1 EGFR
52 male reproductive organ cancer 9.8 CCND1 CDH1
53 in situ carcinoma 9.8 CDH1 CDKN2A EGFR
54 chordoma 9.8 CDH1 CDKN2A EGFR
55 transitional cell carcinoma 9.8 CDH1 CDKN2A EGFR
56 gallbladder cancer 9.8 CDH1 CDKN2A EGFR
57 autosomal dominant polycystic kidney disease 9.7 CDH1 EGFR
58 familial adenomatous polyposis 9.7 CCND1 CDH1
59 mantle cell lymphoma 9.7 CCND1 CDKN2A
60 penile cancer 9.7 CCND1 CDKN2A EGFR
61 esophageal disease 9.7 CCND1 CDKN2A EGFR
62 nervous system cancer 9.7 CCND1 CDKN2A EGFR
63 larynx cancer 9.7 CCND1 CDKN2A EGFR
64 lynch syndrome 9.6 CCND1 CDKN2A EGFR
65 gastrointestinal stromal tumor 9.6 CCND1 CDKN2A EGFR
66 glioma 9.6 CCND1 CDKN2A EGFR
67 glioblastoma 9.6 CCND1 CDKN2A EGFR
68 glioblastoma multiforme 9.6 CCND1 CDKN2A EGFR
69 nasopharyngeal disease 9.6 CCND1 CDH1 CDKN2A
70 cervix disease 9.6 CCND1 CDH1 CDKN2A
71 uterine anomalies 9.6 CCND1 CDH1 CDKN2A
72 bladder disease 9.6 CCND1 CDH1 CDKN2A
73 ductal carcinoma in situ 9.6 CCND1 CDH1 EGFR
74 tongue cancer 9.6 CCND1 CDH1 CDKN2A
75 colonic disease 9.6 CCND1 CDH1 EGFR
76 stomach disease 9.6 CCND1 CDH1 EGFR
77 breast ductal carcinoma 9.6 CCND1 CDH1 EGFR
78 intestinal disease 9.6 CCND1 CDH1 EGFR
79 cervical cancer 9.5 CCND1 CDH1 CDKN2A
80 thyroid cancer 9.5 CCND1 CDH1 EGFR
81 barrett esophagus 9.5 CCND1 CDKN2A
82 pre-malignant neoplasm 9.3 CCND1 CDH1 CDKN2A EGFR
83 laryngeal disease 9.3 CCND1 CDH1 CDKN2A EGFR
84 oropharynx cancer 9.3 CCND1 CDH1 CDKN2A EGFR
85 pharynx cancer 9.3 CCND1 CDH1 CDKN2A EGFR
86 laryngeal squamous cell carcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
87 oral cancer 9.3 CCND1 CDH1 CDKN2A EGFR
88 female reproductive system disease 9.3 CCND1 CDH1 CDKN2A EGFR
89 reproductive system disease 9.3 CCND1 CDH1 CDKN2A EGFR
90 respiratory system cancer 9.3 CCND1 CDH1 CDKN2A EGFR
91 gastrointestinal system cancer 9.3 CCND1 CDH1 CDKN2A EGFR
92 endocrine gland cancer 9.3 CCND1 CDH1 CDKN2A EGFR
93 gastrointestinal system disease 9.3 CCND1 CDH1 CDKN2A EGFR
94 ovarian cancer 9.3 CCND1 CDH1 EGFR
95 pancreas adenocarcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
96 adenocarcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
97 adamantinoma of long bones 9.3 CCND1 CDH1 CDKN2A EGFR
98 cholangiocarcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
99 squamous cell carcinoma, head and neck 9.3 CCND1 CDH1 CDKN2A EGFR
100 large intestine cancer 9.3 CCND1 CDH1 CDKN2A EGFR
101 nasopharyngeal carcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
102 gastric adenocarcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
103 lung cancer 9.3 CCND1 CDH1 CDKN2A EGFR
104 lung cancer susceptibility 3 9.3 CCND1 CDH1 CDKN2A EGFR
105 bladder cancer 9.3 CCND1 CDH1 CDKN2A EGFR
106 esophageal cancer 9.3 CCND1 CDH1 CDKN2A EGFR
107 endometrial cancer 9.3 CCND1 CDH1 CDKN2A EGFR
108 ewing sarcoma 9.3 CCND1 CDH1 CDKN2A EGFR
109 pancreatic cancer 9.3 CCND1 CDH1 CDKN2A EGFR
110 gastric cancer 9.3 CCND1 CDH1 CDKN2A EGFR
111 hepatocellular carcinoma 9.3 CCND1 CDH1 CDKN2A EGFR
112 colorectal cancer 9.1 CCND1 CDH1 CDKN2A EGFR

Graphical network of the top 20 diseases related to Esophagus Verrucous Carcinoma:



Diseases related to Esophagus Verrucous Carcinoma

Symptoms & Phenotypes for Esophagus Verrucous Carcinoma

GenomeRNAi Phenotypes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

27 (showing 22, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.7 EGFR
2 Decreased viability GR00221-A-1 9.7 CDH1 CDKN2A EGFR
3 Decreased viability GR00221-A-3 9.7 CDKN2A
4 Decreased viability GR00221-A-4 9.7 CDKN2A EGFR
5 Decreased viability GR00301-A 9.7 CDH1
6 Decreased viability GR00402-S-2 9.7 CDH1 CDKN2A EGFR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.55 EGFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.55 EGFR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.55 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.55 CCND1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.55 CCND1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.55 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.55 CCND1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.55 EGFR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.55 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.55 CCND1 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.55 CCND1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.55 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.55 CCND1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.55 CCND1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.55 EGFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 EGFR

MGI Mouse Phenotypes related to Esophagus Verrucous Carcinoma:

47 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.67 CCND1 CDH1 CDKN2A EGFR
2 digestive/alimentary MP:0005381 9.62 CCND1 CDH1 CDKN2A EGFR
3 endocrine/exocrine gland MP:0005379 9.56 CCND1 CDH1 CDKN2A EGFR
4 integument MP:0010771 9.46 CCND1 CDH1 CDKN2A EGFR
5 neoplasm MP:0002006 9.26 CCND1 CDH1 CDKN2A EGFR
6 reproductive system MP:0005389 8.92 CCND1 CDH1 CDKN2A EGFR

Drugs & Therapeutics for Esophagus Verrucous Carcinoma

Drugs for Esophagus Verrucous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 1, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antioxidants Phase 2

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Efficacy of VIUSID® Plus GLIZIGEN® in Patients With Papilloma Virus Esophageal Completed NCT03584308 Phase 2

Search NIH Clinical Center for Esophagus Verrucous Carcinoma

Genetic Tests for Esophagus Verrucous Carcinoma

Anatomical Context for Esophagus Verrucous Carcinoma

MalaCards organs/tissues related to Esophagus Verrucous Carcinoma:

42
Breast, Lung, Tongue, Tonsil, Kidney, Colon, Bone

Publications for Esophagus Verrucous Carcinoma

Articles related to Esophagus Verrucous Carcinoma:

(showing 19, show less)
# Title Authors Year
1
Verrucous carcinoma of the esophagus: A rare entity with a difficult diagnosis. ( 29452967 )
2018
2
Verrucous carcinoma of the esophagus-remains a diagnostic enigma. ( 29748561 )
2018
3
Verrucous Carcinoma of the Esophagus. ( 27803424 )
2016
4
VERRUCOUS CARCINOMA OF THE ESOPHAGUS INVOLVING THE ENTIRE ESOPHAGUS. ( 26734805 )
2015
5
Verrucous carcinoma of the esophagus: A case report and literature review. ( 25032204 )
2014
6
Verrucous carcinoma of the esophagus: a potential diagnostic dilemma. ( 24474899 )
2013
7
Verrucous carcinoma of the esophagus. ( 23039810 )
2012
8
Verrucous carcinoma of the esophagus: a rare variant of squamous cell carcinoma for which a preoperative diagnosis can be a difficult one to make. ( 22272545 )
2011
9
Verrucous carcinoma of the esophagus: a complex diagnosis. ( 20405383 )
2010
10
Verrucous carcinoma of the esophagus. ( 19555942 )
2009
11
Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. ( 15229749 )
2004
12
Verrucous carcinoma of the esophagus: clinicopathophysiologic features and treatment of a rare entity. ( 12757157 )
2003
13
Verrucous carcinoma of the esophagus. ( 11293774 )
2001
14
Verrucous carcinoma of the esophagus completely resected by endoscopy. ( 10763964 )
2000
15
Long-term survival in a patient with verrucous carcinoma of the esophagus. ( 8633546 )
1996
16
Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. ( 8030818 )
1994
17
Verrucous carcinoma of the esophagus. ( 3229394 )
1988
18
Verrucous acanthosis--so-called verrucous carcinoma--of the esophagus. ( 3564599 )
1987
19
Verrucous carcinoma of the esophagus. ( 6507406 )
1984

Variations for Esophagus Verrucous Carcinoma

Expression for Esophagus Verrucous Carcinoma

Search GEO for disease gene expression data for Esophagus Verrucous Carcinoma.

Pathways for Esophagus Verrucous Carcinoma

Pathways related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(showing 30, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 CCND1 CDH1 CDKN2A EGFR
2
Show member pathways
12.58 CCND1 CDKN2A EGFR
3
Show member pathways
12.41 CCND1 CDH1 CDKN2A EGFR
4 12.35 CCND1 CDH1 CDKN2A EGFR
5
Show member pathways
12.19 CCND1 CDH1 EGFR
6 12.16 CCND1 CDKN2A EGFR
7
Show member pathways
12.15 CCND1 CDH1 CDKN2A EGFR
8
Show member pathways
12.12 CCND1 CDH1 CDKN2A EGFR
9 12.01 CCND1 CDH1 CDKN2A
10 11.85 CCND1 CDH1 EGFR
11 11.8 CCND1 CDH1 EGFR
12
Show member pathways
11.78 CCND1 EGFR
13 11.77 CCND1 CDH1
14
Show member pathways
11.75 CCND1 EGFR
15 11.71 CCND1 EGFR
16 11.68 CCND1 CDKN2A
17 11.63 CCND1 CDKN2A EGFR
18
Show member pathways
11.57 CDH1 EGFR
19 11.56 CCND1 EGFR
20 11.49 CCND1 CDH1
21 11.44 CDH1 EGFR
22
Show member pathways
11.42 CCND1 EGFR
23 11.39 CCND1 EGFR
24
Show member pathways
11.31 CCND1 EGFR
25 11.16 CDH1 EGFR
26 11.07 CCND1 CDH1
27 11.03 CDH1 EGFR
28 10.84 CCND1 CDKN2A EGFR
29 10.79 CCND1 CDH1 CDKN2A EGFR
30 10.77 CDH1 EGFR

GO Terms for Esophagus Verrucous Carcinoma

Biological processes related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.46 CCND1 EGFR
2 response to estradiol GO:0032355 9.43 CCND1 EGFR
3 positive regulation of transcription, DNA-templated GO:0045893 9.43 CDH1 CDKN2A EGFR
4 G1/S transition of mitotic cell cycle GO:0000082 9.4 CCND1 CDKN2A
5 response to organic substance GO:0010033 9.37 CCND1 CDH1
6 liver development GO:0001889 9.32 CCND1 EGFR
7 response to calcium ion GO:0051592 9.16 CCND1 EGFR
8 liver regeneration GO:0097421 8.96 CCND1 EGFR
9 response to UV-A GO:0070141 8.62 CCND1 EGFR

Molecular functions related to Esophagus Verrucous Carcinoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 8.8 CCND1 CDKN2A EGFR

Sources for Esophagus Verrucous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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