MCID: EST005
MIFTS: 43

Esotropia

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Esotropia

MalaCards integrated aliases for Esotropia:

Name: Esotropia 12 77 54 30 6 15 74
Convergence in Manifest Squint 12
Internal Strabismus 12
Crossed Eyes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9840
ICD9CM 36 378.0 378.00
MeSH 45 D004948
NCIt 51 C34596
SNOMED-CT 69 16596007
ICD10 34 H50.0 H50.00
UMLS 74 C0014877

Summaries for Esotropia

Disease Ontology : 12 A strabismus that is characterized the eye which turns inward toward the nose.

MalaCards based summary : Esotropia, also known as convergence in manifest squint, is related to alternating esotropia and accommodative esotropia. An important gene associated with Esotropia is TFAP2A (Transcription Factor AP-2 Alpha). The drugs Acetylcholine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotype is hearing/vestibular/ear.

Wikipedia : 77 Esotropia is a form of strabismus in which one or both eyes turns inward. The condition can be... more...

Related Diseases for Esotropia

Diseases related to Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 alternating esotropia 33.6 CHN1 KANTR
2 accommodative esotropia 33.4 CHN1 COG8 KANTR
3 abducens nerve disease 32.0 CHN1 KANTR
4 ocular motility disease 31.4 CHN1 KANTR ROBO3
5 strabismus 30.8 ADAT3 CHN1 COL11A1 SOBP
6 amblyopia 30.8 CHN1 SOBP TFAP2A
7 anisometropia 30.6 CHN1 COG8
8 enophthalmos 30.0 CHN1 TFAP2A
9 hypotropia 29.8 CHN1 KANTR
10 hypertropia 29.5 CHN1 KANTR
11 paralytic squint 29.3 CHN1 KANTR
12 monocular esotropia 12.4
13 blepharophimosis with ptosis, syndactyly, and short stature 11.8
14 exotropia 11.5
15 hemifacial hyperplasia with strabismus 11.3
16 moebius syndrome 11.1
17 marshall syndrome 11.0
18 orofaciodigital syndrome iii 11.0
19 richieri-costa/guion-almeida syndrome 11.0
20 spinocerebellar ataxia, x-linked 3 11.0
21 mental retardation, anterior maxillary protrusion, and strabismus 11.0
22 facial paresis, hereditary congenital, 3 11.0
23 mental retardation, autosomal recessive 36 11.0
24 bestrophinopathy 11.0
25 jackson-weiss syndrome 11.0
26 skin creases, congenital symmetric circumferential, 1 11.0
27 neurodegeneration with brain iron accumulation 2a 11.0
28 coats disease 11.0
29 craniofrontonasal syndrome 11.0
30 incontinentia pigmenti 11.0
31 infantile cerebellar-retinal degeneration 11.0
32 xia-gibbs syndrome 11.0
33 oculocutaneous albinism 11.0
34 polymicrogyria 11.0
35 autosomal dominant intellectual disability 49 11.0
36 iqsec2 11.0
37 ophn1 syndrome 11.0
38 myopia 10.4
39 refractive error 10.3
40 suppression amblyopia 10.2
41 epicanthus 10.2 ANKRD11 TFAP2A
42 alternating exotropia 10.2
43 mechanical strabismus 10.2
44 orbital disease 10.2 CHN1 TFAP2A
45 pathologic nystagmus 10.2
46 monofixation syndrome 10.2
47 postcholecystectomy syndrome 10.2 KANTR SOBP
48 duane retraction syndrome 1 10.1
49 cataract 10.1
50 ptosis 10.1

Graphical network of the top 20 diseases related to Esotropia:



Diseases related to Esotropia

Symptoms & Phenotypes for Esotropia

MGI Mouse Phenotypes related to Esotropia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.02 ANKRD11 COL11A1 ROBO3 SOBP TFAP2A

Drugs & Therapeutics for Esotropia

Drugs for Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-84-3 187
2 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 abobotulinumtoxinA Phase 4,Phase 3
4 Botulinum Toxins Phase 4,Phase 3,Not Applicable
5 Neuromuscular Agents Phase 4,Phase 3
6 Acetylcholine Release Inhibitors Phase 4,Phase 3,Not Applicable
7 Cholinergic Agents Phase 4,Phase 3,Not Applicable
8 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
9 Botulinum Toxins, Type A Phase 4,Phase 3
10 Pharmaceutical Solutions Phase 4
11
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
12
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
13
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
14 Central Nervous System Depressants Phase 2, Phase 3,Not Applicable
15 Anesthetics Phase 2, Phase 3,Not Applicable
16 Anesthetics, Local Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
19
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
20
tannic acid Approved Not Applicable 1401-55-4
21
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
22
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
23 Neurotransmitter Uptake Inhibitors Not Applicable
24 Dopamine Agents Not Applicable
25 Autonomic Agents Not Applicable
26 Sympathomimetics Not Applicable
27 Central Nervous System Stimulants Not Applicable
28 Dopamine Uptake Inhibitors Not Applicable
29 Adrenergic Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
3 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
4 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
5 Botox Instead of Strabismus Surgery (BISS) Recruiting NCT03459092 Phase 3 Botulinum toxin type A
6 The Effect of Slanted Recession of Horizontal Muscle on Horizontal Strabismus With Abnormal Accommodative Convergence /Accommodation Ratio (AC/A) Recruiting NCT03555045 Phase 2, Phase 3
7 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
8 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
9 Conservative Treatment of Esotropia in Children up to 3 Years Old Unknown status NCT02404324 Not Applicable
10 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174 Not Applicable
11 Comparison Between Augmented Recession and Posterior Scleral Fixation in Partially Accommodative Esotropia Unknown status NCT02413463 Not Applicable
12 Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin Completed NCT00746304
13 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711 Not Applicable
14 Early Versus Delayed Surgery for Infantile Esotropia Completed NCT01166503
15 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960
16 Congenital Esotropia Observational Study (CEOS) Completed NCT00000163
17 Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia Completed NCT00304577
18 Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye Completed NCT00001143
19 Strabismus Surgery and Driving Ability Completed NCT02570555
20 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946 Not Applicable
21 Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS) Completed NCT00821223 Not Applicable
22 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents. Completed NCT00214487 Not Applicable
23 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847
24 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603 Not Applicable
25 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549 Not Applicable
26 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836 Not Applicable
27 Enhancement of Emmetropization in Highly Hyperopic Infants Not yet recruiting NCT03669146 Not Applicable

Search NIH Clinical Center for Esotropia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Esotropia

Genetic tests related to Esotropia:

# Genetic test Affiliating Genes
1 Esotropia 30

Anatomical Context for Esotropia

MalaCards organs/tissues related to Esotropia:

42
Eye, Brain, Testes, Pituitary, Thyroid, Cortex, Retina

Publications for Esotropia

Articles related to Esotropia:

(show top 50) (show all 1188)
# Title Authors Year
1
Changes in axial length in accommodative esotropia patients with minimal hyperopic correction. ( 30682011 )
2019
2
Acquired, Comitant, Non-Accommodative Esotropia (ANAET): Evaluation, Treatment, and Prognosis. ( 30806582 )
2019
3
Lateral rectus dermoid cyst presenting as incomitant esotropia. ( 30691358 )
2019
4
Infrared photographs with a selective wavelength filter to diagnose small-angle esotropia in young children. ( 30661115 )
2019
5
The management of large-angle esotropia in Graves ophthalmopathy with combined medial rectus recession and lateral rectus resection. ( 30664931 )
2019
6
Magnetic resonance imaging findings of age-related distance esotropia in Japanese patients with high myopia. ( 30671656 )
2019
7
Consecutive cyclic esotropia - A case report. ( 30672495 )
2019
8
Lateral rectus sag and recurrent esotropia in children. ( 30797977 )
2019
9
Outcomes of Medial Rectus Recession With Adjustable Suture in Acute Concomitant Esotropia of Adulthood. ( 30889264 )
2019
10
The difference of surgical outcomes between manifest exotropia and esotropia. ( 29922977 )
2018
11
Essential Infantile Esotropia: Potential Pathogenetic Role of Extended Subcortical Neuroplasticity. ( 29677359 )
2018
12
Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy. ( 29339065 )
2018
13
The Effect of Prism Adaptation on the Angle of Deviation in Convergence Excess Esotropia and Possible Consequences for Surgical Planning. ( 29889586 )
2018
14
Long-term evolution of age-related distance esotropia. ( 29551605 )
2018
15
Objective ocular torsion outcomes after unilateral horizontal rectus surgery in infantile esotropia. ( 29860547 )
2018
16
Immediate Postoperative Alignment Following Bimedial Rectus Recession for Esotropia in Children Compared to Adults. ( 29913023 )
2018
17
Stereoacuity outcomes following surgical correction of the nonaccommodative component in partially accommodative esotropia. ( 29526713 )
2018
18
The relationship between abduction deficit and reoperation among patients with infantile esotropia. ( 29600183 )
2018
19
Anterior Segment Changes during Accommodation in Accommodative Esotropia. ( 29376230 )
2018
20
Monocular surgery to correct large-angle esotropia: a 10-year follow-up study. ( 29924192 )
2018
21
The effects of partial and full correction of refractive errors on sensorial and motor outcomes in children with refractive accommodative esotropia. ( 29549487 )
2018
22
The Preferred Postoperative Alignment in Infantile Esotropia. ( 29543976 )
2018
23
Tendon Elongation with Bovine Pericardium in Patients with Severe Esotropia after Decompression in Graves' Orbitopathy-efficacy and Long-term Stability. ( 29557700 )
2018
24
Reduction of Consecutive Esotropia Using Modified Contralateral Recession and Resection for Recurrent Intermittent Exotropia. ( 28991342 )
2018
25
Evaluation and surgical outcome of acquired nonaccommodative esotropia among older children. ( 29426440 )
2018
26
Amblyopia in High Accommodative Convergence/Accommodation Ratio Accommodative Esotropia. Influence of Bifocals on Treatment Outcome. ( 29729255 )
2018
27
Intermittent Esotropia in 4 Patients With Allan-Herndon-Dudley Syndrome. ( 29714107 )
2018
28
Esotropia and Exotropia Preferred Practice PatternAr. ( 29108746 )
2018
29
Clinical Research on the Efficacy of Modified Surgery for Esotropia Fixus With High Myopia. ( 29709045 )
2018
30
Clinical study of the influence of preoperative wearing time on postoperative effects in children with partially accommodative esotropia. ( 29742698 )
2018
31
Spontaneous consecutive esotropia. ( 29497134 )
2018
32
The Effect of Botulinum Toxin Augmentation on Strabismus Surgery for Large-Angle InfantileA Esotropia. ( 29476725 )
2018
33
Accommodative esotropia: the state of the art. ( 29332227 )
2018
34
Factors influencing stereopsis in patients with both refractive accommodative esotropia and amblyopia. ( 29704131 )
2018
35
The Role of Dynamic Retinoscopy in Predicting Infantile Accommodative Esotropia and Influencing Emmetropization. ( 30196757 )
2018
36
Long-term motor and sensory outcomes after surgery for the nonaccommodative component of partially refractive accommodative esotropia. ( 30217512 )
2018
37
Long-term development of refractive error in refractive, nonrefractive and partially accommodative esotropia. ( 30248135 )
2018
38
Esodeviation without correction for tapering hyperopia in refractive accommodative esotropia. ( 30340709 )
2018
39
Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. ( 30415012 )
2018
40
Acquired distance esotropia associated with myopia in the young adult. ( 29463226 )
2018
41
Long-term Surgical Outcomes for Large-angle Infantile Esotropia. ( 29470973 )
2018
42
A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. ( 29985743 )
2018
43
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. ( 30025141 )
2018
44
Morning Glory Disc Anomaly in a Child with Esotropia. ( 30025671 )
2018
45
Decompensated Esophoria as a Benign Cause of Acquired Esotropia. ( 30053478 )
2018
46
Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect. ( 30098192 )
2018
47
Comparative Study of Y-Split Recession versus Faden Technique for Management of Infantile Esotropia in Egyptians. ( 30155281 )
2018
48
Application of SRT plus MR recession in supra-maximal esotropia from chronic sixth nerve palsy. ( 30182295 )
2018
49
Short prism adaptation test in patients with acquired nonaccommodative esotropia; clinical findings and surgical outcome. ( 30227245 )
2018
50
Comparison of Surgical Outcomes Between Bilateral Medial Rectus Recession and Unilateral Recess-Resect for Infantile Esotropia. ( 30252566 )
2018

Variations for Esotropia

ClinVar genetic disease variations for Esotropia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633
2 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh38 Chromosome 16, 89281225: 89281225
3 46;XY;t(3;17)(p14.3;q24.3)dn Translocation Likely pathogenic
4 46;XY;t(4;14)(p15.32;q32.1)dn Translocation Uncertain significance
5 46;XY;t(1;3)(p22;q21)dn Translocation Uncertain significance
6 TFAP2A NM_003220.2(TFAP2A): c.1037_1038delAA (p.Lys346Argfs) deletion Pathogenic rs1554110735 GRCh37 Chromosome 6, 10398926: 10398927
7 TFAP2A NM_003220.2(TFAP2A): c.1037_1038delAA (p.Lys346Argfs) deletion Pathogenic rs1554110735 GRCh38 Chromosome 6, 10398693: 10398694
8 SLC9A6 NM_001042537.1(SLC9A6): c.1728-19_1728-3delTCTTCCTTAACCACCGC deletion Likely pathogenic GRCh38 Chromosome X, 136040057: 136040073
9 SLC9A6 NM_001042537.1(SLC9A6): c.1728-19_1728-3delTCTTCCTTAACCACCGC deletion Likely pathogenic GRCh37 Chromosome X, 135122216: 135122232

Expression for Esotropia

Search GEO for disease gene expression data for Esotropia.

Pathways for Esotropia

GO Terms for Esotropia

Biological processes related to Esotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system morphogenesis GO:0048705 9.16 ANKRD11 COL11A1
2 sensory perception of sound GO:0007605 9.13 COL11A1 SOBP TFAP2A
3 inner ear morphogenesis GO:0042472 8.8 COL11A1 SOBP TFAP2A

Sources for Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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