MCID: EST005
MIFTS: 44

Esotropia

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Esotropia

MalaCards integrated aliases for Esotropia:

Name: Esotropia 12 76 53 29 6 15 73
Convergence in Manifest Squint 12
Internal Strabismus 12
Crossed Eyes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9840
ICD10 33 H50.0 H50.00
ICD9CM 35 378.0 378.00
MeSH 44 D004948
NCIt 50 C34596
SNOMED-CT 68 16596007
UMLS 73 C0014877

Summaries for Esotropia

Disease Ontology : 12 Esotropia is a strabismus in which the eye turns inward toward the nose.

MalaCards based summary : Esotropia, also known as convergence in manifest squint, is related to accommodative esotropia and exotropia. An important gene associated with Esotropia is ANKRD11 (Ankyrin Repeat Domain 11). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are growth/size/body region and hearing/vestibular/ear

Wikipedia : 76 Esotropia is a form of strabismus in which one or both eyes turns inward. The condition can be... more...

Related Diseases for Esotropia

Diseases related to Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 accommodative esotropia 33.5 CHN1 COG8 PLA2G16
2 exotropia 32.4 CHN1 TUBB3
3 ocular motility disease 31.3 CHN1 PLA2G16 ROBO3 TUBB3
4 strabismus 30.3 ADAT3 CHN1 COL11A1 PLA2G16 SOBP TUBB3
5 anisometropia 30.3 CHN1 COG8 OPTN
6 amblyopia 30.1 CHN1 OPTN PLA2G16 SOBP TFAP2A TUBB3
7 congenital ptosis 30.0 CHN1 TUBB3
8 enophthalmos 29.9 CHN1 TFAP2A
9 hypotropia 29.9 CHN1 OPTN TUBB3
10 hypertropia 29.8 CHN1 TUBB3
11 paralytic squint 29.7 CHN1 TUBB3
12 nervous system disease 29.6 KMT2D OPTN TUBB3
13 monocular esotropia 12.4
14 alternating esotropia 12.3
15 blepharophimosis with ptosis, syndactyly, and short stature 11.8
16 abducens nerve disease 11.3
17 hemifacial hyperplasia with strabismus 11.3
18 moebius syndrome 11.1
19 marshall syndrome 11.0
20 orofaciodigital syndrome iii 11.0
21 richieri-costa/guion-almeida syndrome 11.0
22 spinocerebellar ataxia, x-linked 3 11.0
23 mental retardation, anterior maxillary protrusion, and strabismus 11.0
24 facial paresis, hereditary congenital, 3 11.0
25 mental retardation, autosomal recessive 36 11.0
26 jackson-weiss syndrome 10.9
27 neurodegeneration with brain iron accumulation 2a 10.9
28 coats disease 10.9
29 craniofrontonasal syndrome 10.9
30 incontinentia pigmenti 10.9
31 infantile cerebellar-retinal degeneration 10.9
32 xia-gibbs syndrome 10.9
33 oculocutaneous albinism 10.9
34 polymicrogyria 10.9
35 iqsec2 10.9
36 ophn1 syndrome 10.9
37 myopia 10.4
38 refractive error 10.2
39 alternating exotropia 10.2
40 orbital disease 10.2 CHN1 TFAP2A
41 marcus gunn phenomenon 10.2 CHN1 TUBB3
42 vitreous syneresis 10.2 COL11A1 OPTN
43 epicanthus 10.1 ANKRD11 TFAP2A
44 ptosis 10.1
45 monofixation syndrome 10.1
46 corneal staphyloma 10.1 KMT2D OPTN
47 lacrimal duct obstruction 10.1 OPTN TFAP2A
48 duane retraction syndrome 1 10.1
49 cataract 10.1
50 supranuclear ocular palsy 10.1

Graphical network of the top 20 diseases related to Esotropia:



Diseases related to Esotropia

Symptoms & Phenotypes for Esotropia

MGI Mouse Phenotypes related to Esotropia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 ANKRD11 CHN1 COL11A1 EBP KMT2D PLA2G16
2 hearing/vestibular/ear MP:0005377 9.43 ANKRD11 COL11A1 KMT2D ROBO3 SOBP TFAP2A
3 mortality/aging MP:0010768 9.36 ANKRD11 CHN1 COL11A1 EBP KMT2D OPTN

Drugs & Therapeutics for Esotropia

Drugs for Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Not Applicable 51-84-3 187
2 Botulinum Toxins Phase 4,Phase 3,Not Applicable
3 Acetylcholine Release Inhibitors Phase 4,Phase 3,Not Applicable
4 abobotulinumtoxinA Phase 4,Phase 3
5 onabotulinumtoxinA Phase 4,Phase 3
6 Botulinum Toxins, Type A Phase 4,Phase 3
7 Cholinergic Agents Phase 4,Phase 3,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
10 Neuromuscular Agents Phase 4,Phase 3
11 Pharmaceutical Solutions Phase 4
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
14
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
15 Central Nervous System Depressants Phase 2, Phase 3,Not Applicable
16 Anesthetics Phase 2, Phase 3,Not Applicable
17 Anesthetics, Local Phase 2, Phase 3
18 Epinephryl borate Phase 2, Phase 3
19
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
20 tannic acid Approved Not Applicable
21
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
22
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
23
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
24 Neurotransmitter Uptake Inhibitors Not Applicable
25 Adrenergic Agents Not Applicable
26 Autonomic Agents Not Applicable
27 Sympathomimetics Not Applicable
28 Dopamine Uptake Inhibitors Not Applicable
29 Dopamine Agents Not Applicable
30 Central Nervous System Stimulants Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
3 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
4 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
5 Botox Instead of Strabismus Surgery (BISS) Recruiting NCT03459092 Phase 3 Botulinum toxin type A
6 The Effect of Slanted Recession of Horizontal Muscle on Horizontal Strabismus With Abnormal Accommodative Convergence /Accommodation Ratio (AC/A) Recruiting NCT03555045 Phase 2, Phase 3
7 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
8 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
9 Conservative Treatment of Esotropia in Children up to 3 Years Old Unknown status NCT02404324 Not Applicable
10 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174 Not Applicable
11 Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin Completed NCT00746304
12 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711 Not Applicable
13 Early Versus Delayed Surgery for Infantile Esotropia Completed NCT01166503
14 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960
15 Congenital Esotropia Observational Study (CEOS) Completed NCT00000163
16 Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia Completed NCT00304577
17 Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye Completed NCT00001143
18 Strabismus Surgery and Driving Ability Completed NCT02570555
19 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946 Not Applicable
20 Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS) Completed NCT00821223 Not Applicable
21 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents. Completed NCT00214487 Not Applicable
22 Comparison Between Augmented Recession and Posterior Scleral Fixation in Partially Accommodative Esotropia Recruiting NCT02413463 Not Applicable
23 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847
24 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603 Not Applicable
25 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549 Not Applicable
26 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836 Not Applicable
27 Enhancement of Emmetropization in Highly Hyperopic Infants Not yet recruiting NCT03669146 Not Applicable

Search NIH Clinical Center for Esotropia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Esotropia

Genetic tests related to Esotropia:

# Genetic test Affiliating Genes
1 Esotropia 29

Anatomical Context for Esotropia

MalaCards organs/tissues related to Esotropia:

41
Eye, Brain, Testes, Pituitary, Thyroid, Retina, Cortex

Publications for Esotropia

Articles related to Esotropia:

(show top 50) (show all 1052)
# Title Authors Year
1
The difference of surgical outcomes between manifest exotropia and esotropia. ( 29922977 )
2018
2
Essential Infantile Esotropia: Potential Pathogenetic Role of Extended Subcortical Neuroplasticity. ( 29677359 )
2018
3
Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy. ( 29339065 )
2018
4
The Effect of Prism Adaptation on the Angle of Deviation in Convergence Excess Esotropia and Possible Consequences for Surgical Planning. ( 29889586 )
2018
5
Long-term evolution of age-related distance esotropia. ( 29551605 )
2018
6
Objective ocular torsion outcomes after unilateral horizontal rectus surgery in infantile esotropia. ( 29860547 )
2018
7
Immediate Postoperative Alignment Following Bimedial Rectus Recession for Esotropia in Children Compared to Adults. ( 29913023 )
2018
8
Stereoacuity outcomes following surgical correction of the nonaccommodative component in partially accommodative esotropia. ( 29526713 )
2018
9
The relationship between abduction deficit and reoperation among patients with infantile esotropia. ( 29600183 )
2018
10
Anterior Segment Changes during Accommodation in Accommodative Esotropia. ( 29376230 )
2018
11
Monocular surgery to correct large-angle esotropia: a 10-year follow-up study. ( 29924192 )
2018
12
The effects of partial and full correction of refractive errors on sensorial and motor outcomes in children with refractive accommodative esotropia. ( 29549487 )
2018
13
The Preferred Postoperative Alignment in Infantile Esotropia. ( 29543976 )
2018
14
Tendon Elongation with Bovine Pericardium in Patients with Severe Esotropia after Decompression in Graves' Orbitopathy-efficacy and Long-term Stability. ( 29557700 )
2018
15
Reduction of Consecutive Esotropia Using Modified Contralateral Recession and Resection for Recurrent Intermittent Exotropia. ( 28991342 )
2018
16
Evaluation and surgical outcome of acquired nonaccommodative esotropia among older children. ( 29426440 )
2018
17
Amblyopia in High Accommodative Convergence/Accommodation Ratio Accommodative Esotropia. Influence of Bifocals on Treatment Outcome. ( 29729255 )
2018
18
Intermittent Esotropia in 4 Patients With Allan-Herndon-Dudley Syndrome. ( 29714107 )
2018
19
Esotropia and Exotropia Preferred Practice PatternAr. ( 29108746 )
2018
20
Clinical Research on the Efficacy of Modified Surgery for Esotropia Fixus With High Myopia. ( 29709045 )
2018
21
Clinical study of the influence of preoperative wearing time on postoperative effects in children with partially accommodative esotropia. ( 29742698 )
2018
22
Spontaneous consecutive esotropia. ( 29497134 )
2018
23
The Effect of Botulinum Toxin Augmentation on Strabismus Surgery for Large-Angle InfantileA Esotropia. ( 29476725 )
2018
24
Accommodative esotropia: the state of the art. ( 29332227 )
2018
25
Factors influencing stereopsis in patients with both refractive accommodative esotropia and amblyopia. ( 29704131 )
2018
26
The Role of Dynamic Retinoscopy in Predicting Infantile Accommodative Esotropia and Influencing Emmetropization. ( 30196757 )
2018
27
Long-term motor and sensory outcomes after surgery for the nonaccommodative component of partially refractive accommodative esotropia. ( 30217512 )
2018
28
Long-term development of refractive error in refractive, nonrefractive and partially accommodative esotropia. ( 30248135 )
2018
29
Esodeviation without correction for tapering hyperopia in refractive accommodative esotropia. ( 30340709 )
2018
30
Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. ( 30415012 )
2018
31
Acquired distance esotropia associated with myopia in the young adult. ( 29463226 )
2018
32
Long-term Surgical Outcomes for Large-angle Infantile Esotropia. ( 29470973 )
2018
33
A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. ( 29985743 )
2018
34
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. ( 30025141 )
2018
35
Morning Glory Disc Anomaly in a Child with Esotropia. ( 30025671 )
2018
36
Decompensated Esophoria as a Benign Cause of Acquired Esotropia. ( 30053478 )
2018
37
Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect. ( 30098192 )
2018
38
Comparative Study of Y-Split Recession versus Faden Technique for Management of Infantile Esotropia in Egyptians. ( 30155281 )
2018
39
Application of SRT plus MR recession in supra-maximal esotropia from chronic sixth nerve palsy. ( 30182295 )
2018
40
Short prism adaptation test in patients with acquired nonaccommodative esotropia; clinical findings and surgical outcome. ( 30227245 )
2018
41
Comparison of Surgical Outcomes Between Bilateral Medial Rectus Recession and Unilateral Recess-Resect for Infantile Esotropia. ( 30252566 )
2018
42
Comparison of recurrent esotropia and consecutive exotropia with horizontal muscle reoperation in infantile esotropia. ( 30328559 )
2018
43
Long-Term Follow-Up of Cyclic Esotropia. ( 30358489 )
2018
44
Factors affecting the motor outcome after corrective surgery for acquired comitant esotropia. ( 30360648 )
2018
45
Asymmetric Lateral Rectus Muscle Insertion Presenting as Esotropia in a Child With Alagille Syndrome. ( 30388280 )
2018
46
Management of surgical overcorrections following surgery for Duane syndrome with esotropia in primary position. ( 30391554 )
2018
47
Medial and Lateral Rectus Muscle Insertion Distance and Width in Esotropia and Exotropia Patients. ( 28632404 )
2017
48
Evaluation and Management of Acute Acquired Comitant Esotropia in Children. ( 27726470 )
2017
49
Comparison of botulinum toxin with surgery for the treatment of acute-onset, comitant esotropia in children. ( 28057455 )
2017
50
Acute concomitant esotropia in children. ( 28574208 )
2017

Variations for Esotropia

ClinVar genetic disease variations for Esotropia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633
2 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh38 Chromosome 16, 89281225: 89281225
3 TFAP2A NM_003220.2(TFAP2A): c.1037_1038delAA (p.Lys346Argfs) deletion Pathogenic GRCh37 Chromosome 6, 10398926: 10398927
4 TFAP2A NM_003220.2(TFAP2A): c.1037_1038delAA (p.Lys346Argfs) deletion Pathogenic GRCh38 Chromosome 6, 10398693: 10398694

Expression for Esotropia

Search GEO for disease gene expression data for Esotropia.

Pathways for Esotropia

GO Terms for Esotropia

Biological processes related to Esotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system morphogenesis GO:0048705 9.16 ANKRD11 COL11A1
2 sensory perception of sound GO:0007605 9.13 COL11A1 SOBP TFAP2A
3 inner ear morphogenesis GO:0042472 8.8 COL11A1 SOBP TFAP2A

Sources for Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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