MCID: EST004
MIFTS: 37

Estrogen Excess

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Estrogen Excess

MalaCards integrated aliases for Estrogen Excess:

Name: Estrogen Excess 12 15
Hyperestrogenism 12 54 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14336
ICD9CM 34 256.0
NCIt 50 C113344
SNOMED-CT 67 190533004
ICD10 32 E28.0
UMLS 70 C0154209

Summaries for Estrogen Excess

Disease Ontology : 12 An ovarian dysfunction that is characterized by a higher than normal ratio of estrogen.

MalaCards based summary : Estrogen Excess, also known as hyperestrogenism, is related to testicular germ cell cancer and germ cell cancer. An important gene associated with Estrogen Excess is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Glioma and Prolactin Signaling Pathway. The drug Estrogens has been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and pituitary, and related phenotypes are endocrine/exocrine gland and cardiovascular system

Related Diseases for Estrogen Excess

Diseases related to Estrogen Excess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell cancer 30.0 FSHR ESR2 ESR1
2 germ cell cancer 30.0 FSHR ESR2 ESR1
3 leydig cell tumor 29.8 PRL GNRH1 CYP19A1
4 endometrial hyperplasia 29.5 PTEN PGR ESR2 ESR1 CYP19A1
5 hyperprolactinemia 29.4 SHBG PRL GNRH1
6 hypopituitarism 29.4 SHBG PRL GNRH1
7 hypogonadotropic hypogonadism 29.3 SHBG PRL GNRH1 CYP19A1
8 endometrial cancer 29.2 SULT1E1 SHBG PTEN PGR GPER1 GNRH1
9 anovulation 29.1 SHBG PRL GNRH1 FSHR CYP19A1
10 polycystic ovary syndrome 29.1 SHBG PRL GNRH1 FSHR CYP19A1
11 ovarian cyst 29.0 PRL GNRH1 FOXL2 ESR2 CYP19A1
12 endometriosis 28.8 PTEN PGR GNRH1 ESR2 ESR1 CYP19A1
13 amenorrhea 28.7 SHBG PRL GNRH1 FSHR FOXL2 CYP19A1
14 gynecomastia 28.6 SHBG PRL PGR GNRH1 ESR2 ESR1
15 aromatase excess syndrome 28.1 SHBG PGR GPER1 GNRH1 ESR2 ESR1
16 subserous uterine fibroid 10.4 PGR CYP19A1
17 benign metastasizing leiomyoma 10.4 PGR CYP19A1
18 glassy cell carcinoma of the cervix 10.4 PGR ESR1
19 breast intraductal papillomatosis 10.4 PGR ESR1
20 intraductal papilloma 10.4 PGR ESR1
21 nipple carcinoma 10.4 PGR ESR1
22 bartholin's gland adenoma 10.4 PGR ESR1
23 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
24 uterine corpus adenosarcoma 10.4 PGR ESR1
25 bartholin's gland benign neoplasm 10.4 PGR ESR1
26 chronic tympanitis 10.4 PGR ESR1
27 vestibular gland benign neoplasm 10.4 PGR ESR1
28 prostatic cyst 10.4 FSHR EPPIN
29 granulomatous endometritis 10.4 PGR ESR1
30 vulvar syringoma 10.4 PGR ESR1
31 lung leiomyoma 10.4 PGR ESR1
32 ovarian endometrioid stromal sarcoma 10.3 PGR CYP19A1
33 breast scirrhous carcinoma 10.3 PGR ESR1
34 oncocytic breast carcinoma 10.3 PGR ESR1
35 cervical clear cell adenocarcinoma 10.3 PGR ESR1
36 ovarian seromucinous carcinoma 10.3 PGR ESR1
37 mammographic density 10.3 ESR1 CYP19A1
38 breast papillary carcinoma 10.3 PGR ESR1
39 liver leiomyoma 10.3 PGR ESR1
40 nonmucinous bronchioloalveolar adenocarcinoma 10.3 ESR2 ESR1
41 intravenous leiomyomatosis 10.3 PGR ESR1
42 comedo carcinoma 10.3 PGR ESR1
43 breast adenoid cystic carcinoma 10.3 PGR ESR1
44 breast metaplastic carcinoma 10.3 PGR ESR1
45 intracranial meningioma 10.3 PGR ESR1
46 hypoactive sexual desire disorder 10.3 SHBG CYP19A1
47 transsexualism 10.3 ESR2 CYP19A1
48 vulvar leiomyoma 10.3 PGR ESR1
49 bizarre leiomyoma 10.3 PGR ESR1
50 bile duct cystadenoma 10.3 ESR2 ESR1

Graphical network of the top 20 diseases related to Estrogen Excess:



Diseases related to Estrogen Excess

Symptoms & Phenotypes for Estrogen Excess

MGI Mouse Phenotypes related to Estrogen Excess:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 CYP19A1 ESR1 ESR2 FOXL2 FSHR GNRH1
2 cardiovascular system MP:0005385 10.18 CYP19A1 ELAPOR1 ESR1 ESR2 FSHR GPER1
3 hematopoietic system MP:0005397 10.17 CGNL1 CYP19A1 ELAPOR1 ESR1 ESR2 FSHR
4 immune system MP:0005387 10.1 CYP19A1 ELAPOR1 ESR1 ESR2 FSHR GNRH1
5 integument MP:0010771 9.97 CYP19A1 ESR1 ESR2 FSHR GNRH1 PGR
6 limbs/digits/tail MP:0005371 9.87 ELAPOR1 ESR1 ESR2 FSHR GPER1 PGR
7 liver/biliary system MP:0005370 9.8 CYP19A1 ESR1 ESR2 GNRH1 GPER1 PRL
8 reproductive system MP:0005389 9.77 CGNL1 CYP19A1 ELAPOR1 ESR1 ESR2 FOXL2
9 neoplasm MP:0002006 9.7 ESR1 ESR2 FSHR GNRH1 PGR PRL
10 skeleton MP:0005390 9.28 CYP19A1 ELAPOR1 ESR1 ESR2 FSHR GNRH1

Drugs & Therapeutics for Estrogen Excess

Drugs for Estrogen Excess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Estrogens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Molecular Analysis of Estrogen Receptors in Patients With Chronic Venous Disease Completed NCT02558426

Search NIH Clinical Center for Estrogen Excess

Genetic Tests for Estrogen Excess

Anatomical Context for Estrogen Excess

MalaCards organs/tissues related to Estrogen Excess:

40
Breast, Ovary, Pituitary, Liver, Prostate, Uterus, Testis

Publications for Estrogen Excess

Articles related to Estrogen Excess:

(show top 50) (show all 401)
# Title Authors PMID Year
1
[Familial precocious puberty -- a variant of norm or pathology?]. 61 54
16704862 2006
2
The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment. 61 54
16202169 2005
3
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. 54 61
14747944 2004
4
Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme. 61 54
12656667 2003
5
Endometrial biomarkers in premenopausal women with obesity: an at-risk cohort. 61
32835719 2021
6
Estradiol correlates with erectile dysfunction and its severity in type 2 diabetic patients. 61
33028498 2020
7
In vitro maturation with letrozole priming: Can it be a solution for patients with cancerophobia? A pilot study. 61
33343970 2020
8
The Impact of Bariatric Surgery on Menstrual Abnormalities-a Cross-Sectional Study. 61
32661954 2020
9
Diet and gut microbiome interactions in gynecologic cancer. 61
32933758 2020
10
Risk Factors for Tamoxifen-Induced Ovarian Hyperstimulation in Breast Cancer Patients. 61
32727665 2020
11
Sertoli cell tumor/mixed germ cell-stromal cell tumor as separate neoplasms in a bilaterally cryptorchid dog. 61
32879527 2020
12
A case of a unique presentation of a primary vaginal endometrioid adenocarcinoma arising in the setting of a recurrent peritoneal inclusion cyst fistulized to the vagina. 61
32462072 2020
13
Hyperestrogenism on 18F-FDG PET/CT in a Patient With Estrogen-Producing Ovarian Clear Cell Carcinoma. 61
32332298 2020
14
Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology. 61
32154564 2020
15
Development of localized cul-de-sac endometrioid carcinoma associated with deep infiltrating endometriosis during remission of early endometrial cancer. 61
31890832 2020
16
An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis. 61
31878927 2019
17
Combined surgical and medical treatment in an adolescent with severe gynecomastia due to excessive estradiol secretion: a case report. 61
31875785 2019
18
Sclerosing stromal tumor of the ovary in a postmenopausal woman with estrogen excess: A case report. 61
31764859 2019
19
FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. 61
31701078 2019
20
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. 61
31336362 2019
21
Sexual Dysfunction and Sex Hormone Abnormalities in Patients With Cirrhosis: Review of Pathogenesis and Management. 61
30468515 2019
22
Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. 61
30701446 2019
23
Female infertility: which role for obesity? 61
31391925 2019
24
Testosterone and Benign Prostatic Hyperplasia. 61
30803920 2019
25
Adrenal Cortical Carcinoma Associated With Lynch Syndrome: A Case Report and Review of Literature. 61
30963136 2019
26
Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma. 61
29210800 2019
27
Hypertrophic osteoarthropathy: estrogens, prostaglandinE2, prostaglandin A2, and the inflammatory reflex. 61
29480386 2019
28
Ovarian granulosa cell tumor and clomiphene citrate resistance. A case report and review of the literature. 61
30141889 2018
29
Short-Term and Long-Term Effects of Bisphenol A (BPA) Exposure During Breastfeeding on the Biochemical and Endocrine Profiles in Rats. 61
29883975 2018
30
Adult Granulosa Cell Tumor: A Sinister Differential for Clomiphene-resistant Infertility. 61
30158817 2018
31
FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. 61
29471425 2018
32
Long-term estradiol-17β exposure decreases the cholinergic innervation pattern of the pig ovary. 61
29305268 2018
33
Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. 61
29183089 2018
34
Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets. 61
30221009 2018
35
Survivin Expression in Simple Endometrial Polyps and Tamoxifen-associated Endometrial Polyps. 61
28319569 2018
36
Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome. 61
29854508 2018
37
Hyperestrogenism Affects Adult Height Outcome in Growth Hormone Treated Boys With Silver-Russell Syndrome. 61
30622515 2018
38
Ovarian hyperstimulation syndrome due to follicle-stimulating hormone-secreting pituitary adenomas. 61
28676954 2017
39
The Occurrence of Zearalenone in South Korean Feedstuffs between 2009 and 2016. 61
28714869 2017
40
Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review. 61
27565819 2017
41
Biotin interference in immunoassays mimicking subclinical Graves' disease and hyperestrogenism: a case series. 61
27718482 2017
42
Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature. 61
28438188 2017
43
[Fertility-sparing management of endometrial cancer and atypical hyperplasia]. 61
28368791 2017
44
Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. 61
28109061 2017
45
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. 61
28469526 2017
46
Gynecomastia and hormones. 61
27145756 2017
47
Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights. 61
28045098 2017
48
Activity of Zearalenone in the Porcine Intestinal Tract. 61
28029134 2016
49
Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis - Value of Autopsy in a Case Report. 61
27679759 2016
50
Testosterone Aromatization to Estradiol in Course of Ovarian Functioning Brenner Tumor Associated With Endometrial Carcinoma and Endometriosis (Roncati-Manenti Triad). 61
27465894 2016

Variations for Estrogen Excess

Expression for Estrogen Excess

Search GEO for disease gene expression data for Estrogen Excess.

Pathways for Estrogen Excess

GO Terms for Estrogen Excess

Biological processes related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 PTEN ESR2 ESR1
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.56 PTEN PGR ESR2 ESR1
3 response to estradiol GO:0032355 9.54 PTEN ESR1 CYP19A1
4 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR2 ESR1
5 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.43 FSHR ESR1
6 cellular response to estradiol stimulus GO:0071392 9.33 GPER1 ESR2 ESR1
7 uterus development GO:0060065 9.32 FSHR ESR1
8 steroid hormone mediated signaling pathway GO:0043401 9.13 PGR GPER1 ESR1
9 intracellular steroid hormone receptor signaling pathway GO:0030518 8.92 PGR GPER1 ESR2 ESR1

Molecular functions related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.73 SULT1E1 SHBG PTEN PGR ESR2 ESR1
2 enzyme binding GO:0019899 9.71 PTEN PGR ESR2 ESR1
3 nuclear receptor activity GO:0004879 9.54 PGR ESR2 ESR1
4 estrogen receptor activity GO:0030284 9.33 GPER1 ESR2 ESR1
5 estrogen response element binding GO:0034056 9.32 ESR2 ESR1
6 steroid hormone receptor activity GO:0003707 9.26 PGR GPER1 ESR2 ESR1
7 steroid binding GO:0005496 9.1 SULT1E1 SHBG PGR GPER1 ESR2 ESR1

Sources for Estrogen Excess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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