MCID: EST004
MIFTS: 37

Estrogen Excess

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Estrogen Excess

MalaCards integrated aliases for Estrogen Excess:

Name: Estrogen Excess 12 15
Hyperestrogenism 12 55 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14336
ICD10 33 E28.0
ICD9CM 35 256.0
NCIt 50 C113344
SNOMED-CT 68 190533004 37295009
UMLS 73 C0154209

Summaries for Estrogen Excess

MalaCards based summary : Estrogen Excess, also known as hyperestrogenism, is related to aromatase excess syndrome and leydig cell tumor. An important gene associated with Estrogen Excess is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Nuclear Receptor transcription pathway. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Hyperestrogenism, hyperestrogenic state, or estrogen excess, is a medical condition characterized by an... more...

Related Diseases for Estrogen Excess

Diseases related to Estrogen Excess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 aromatase excess syndrome 33.7 CGNL1 CYP19A1
2 leydig cell tumor 30.1 CYP19A1 LHCGR
3 polycystic ovary syndrome 29.5 CYP19A1 FSHR SHBG
4 precocious puberty 29.4 CYP19A1 LHCGR
5 hyperandrogenism 10.9
6 mccune-albright syndrome 10.9
7 benign metastasizing leiomyoma 10.6 CYP19A1 PGR
8 endometrial stromal nodule 10.6 CYP19A1 PGR
9 hypoactive sexual desire disorder 10.5 CYP19A1 SHBG
10 androgen insensitivity, partial 10.5 CYP19A1 SHBG
11 transsexualism 10.5 CYP19A1 ESR2
12 alopecia, androgenetic, 1 10.5 CYP19A1 SHBG
13 androgenic alopecia 10.4 CYP19A1 SHBG
14 complete androgen insensitivity syndrome 10.4 CYP19A1 SHBG
15 uterine body mixed cancer 10.4 ESR2 PGR
16 endometrial disease 10.3 CYP19A1 ESR1
17 vulvar syringoma 10.3 ESR1 PGR
18 lung leiomyoma 10.3 ESR1 PGR
19 vestibular gland benign neoplasm 10.3 ESR1 PGR
20 bartholin's gland adenoma 10.3 ESR1 PGR
21 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
22 aromatase deficiency 10.3 CYP19A1 ESR1
23 vulvar benign neoplasm 10.3 ESR1 PGR
24 trigonitis 10.3 ESR1 PGR
25 vulvar leiomyoma 10.3 ESR1 PGR
26 predominantly cortical thymoma 10.3 ESR1 PGR
27 breast medullary carcinoma 10.3 ESR1 PGR
28 breast scirrhous carcinoma 10.3 ESR1 PGR
29 cribriform carcinoma 10.3 ESR1 PGR
30 oncocytic breast carcinoma 10.3 ESR1 PGR
31 endometrial squamous cell carcinoma 10.3 ESR1 PGR
32 gastric signet ring cell adenocarcinoma 10.3 ESR1 PGR
33 endometrial mucinous adenocarcinoma 10.3 ESR1 PGR
34 adenoid basal cell carcinoma 10.3 ESR1 PGR
35 apocrine adenocarcinoma 10.3 ESR1 PGR
36 premenstrual tension 10.3 PGR SHBG
37 bartholin's gland benign neoplasm 10.3 ESR1 PGR
38 deep angioma 10.3 ESR1 PGR
39 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
40 breast adenoid cystic carcinoma 10.3 ESR1 PGR
41 cervical carcinosarcoma 10.3 ESR1 PGR
42 intramuscular hemangioma 10.3 ESR1 PGR
43 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR
44 retinitis pigmentosa 47 10.3 ESR1 PGR
45 adenomyosis 10.3 ESR1 PGR
46 retinitis pigmentosa 20 10.3 ESR1 PGR
47 luminal breast carcinoma 10.3 ESR1 PGR
48 adenosarcoma 10.2 ESR1 PGR
49 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
50 breast benign neoplasm 10.2 ESR1 PGR

Graphical network of the top 20 diseases related to Estrogen Excess:



Diseases related to Estrogen Excess

Symptoms & Phenotypes for Estrogen Excess

MGI Mouse Phenotypes related to Estrogen Excess:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 CYP19A1 FSHR KIAA1324 ESR1 LHCGR ESR2
2 cellular MP:0005384 9.95 CYP19A1 FSHR KIAA1324 ESR1 LHCGR ESR2
3 cardiovascular system MP:0005385 9.91 CYP19A1 FSHR ESR1 LHCGR ESR2 PGR
4 adipose tissue MP:0005375 9.88 CYP19A1 FSHR ESR1 LHCGR ESR2
5 hematopoietic system MP:0005397 9.87 CYP19A1 FSHR KIAA1324 ESR1 LHCGR ESR2
6 endocrine/exocrine gland MP:0005379 9.85 CYP19A1 FSHR ESR1 LHCGR ESR2 PGR
7 immune system MP:0005387 9.8 CYP19A1 FSHR KIAA1324 ESR1 LHCGR ESR2
8 limbs/digits/tail MP:0005371 9.55 FSHR ESR1 LHCGR ESR2 PGR
9 reproductive system MP:0005389 9.5 FSHR ESR1 KIAA1324 LHCGR ESR2 PGR
10 skeleton MP:0005390 9.1 CYP19A1 FSHR ESR1 LHCGR ESR2 PGR

Drugs & Therapeutics for Estrogen Excess

Drugs for Estrogen Excess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists
4 Estrogens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
2 Norwegian Adenomyosis Study I Completed NCT02201719
3 Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Active, not recruiting NCT02197923

Search NIH Clinical Center for Estrogen Excess

Genetic Tests for Estrogen Excess

Anatomical Context for Estrogen Excess

MalaCards organs/tissues related to Estrogen Excess:

41
Ovary

Publications for Estrogen Excess

Articles related to Estrogen Excess:

# Title Authors Year
1
Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. ( 29183089 )
2018
2
Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? ( 23127146 )
2013
3
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. ( 20172968 )
2010
4
Iatrogenic androgen and estrogen excess in a postmenopausal woman presenting with facial erythema, acne, and hirsutism. ( 19702988 )
2009
5
Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. ( 12736278 )
2003
6
Precocious puberty resulting from congenital hypothalamic hamartoma: persistent darkened areolae after birth as the hallmark of estrogen excess. ( 11307963 )
2001
7
How valid is the prenatal estrogen excess hypothesis of testicular germ cell cancer? A case control study on hormone-related factors. ( 11805417 )
2001
8
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. ( 9178751 )
1997
9
Postmenopausal ovarian follicle cyst: an unusual cause of estrogen excess. ( 6500803 )
1984
10
Cervical cancer; a disordered growth response to inflammation in the presence of estrogen excess and nutritional deficiency; cytological, clinical, nutritional, and pathologic studies. ( 20262967 )
1947

Variations for Estrogen Excess

Expression for Estrogen Excess

Search GEO for disease gene expression data for Estrogen Excess.

Pathways for Estrogen Excess

GO Terms for Estrogen Excess

Biological processes related to Estrogen Excess according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.71 ESR1 ESR2 PGR
2 male gonad development GO:0008584 9.63 ESR1 FSHR LHCGR
3 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.58 ESR1 FSHR LHCGR
4 hormone-mediated signaling pathway GO:0009755 9.57 FSHR LHCGR
5 activation of adenylate cyclase activity GO:0007190 9.56 FSHR LHCGR
6 mammary gland development GO:0030879 9.55 CYP19A1 PGR
7 intracellular estrogen receptor signaling pathway GO:0030520 9.52 ESR1 ESR2
8 androgen metabolic process GO:0008209 9.51 CYP19A1 ESR1
9 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.49 ESR1 FSHR
10 regulation of osteoclast differentiation GO:0045670 9.48 FSHR LHCGR
11 positive regulation of adenylate cyclase activity GO:0045762 9.43 FSHR LHCGR
12 steroid hormone mediated signaling pathway GO:0043401 9.43 ESR1 ESR2 PGR
13 ovulation cycle process GO:0022602 9.37 FSHR LHCGR
14 follicle-stimulating hormone signaling pathway GO:0042699 9.32 FSHR LHCGR
15 primary ovarian follicle growth GO:0001545 9.16 FSHR LHCGR
16 female gonad development GO:0008585 9.13 CYP19A1 FSHR LHCGR
17 uterus development GO:0060065 8.92 CYP19A1 ESR1 FSHR LHCGR

Molecular functions related to Estrogen Excess according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.73 ESR1 ESR2 PGR SHBG
2 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
3 core promoter sequence-specific DNA binding GO:0001046 9.49 ESR1 ESR2
4 G-protein coupled peptide receptor activity GO:0008528 9.48 FSHR LHCGR
5 protein-hormone receptor activity GO:0016500 9.46 FSHR LHCGR
6 nuclear receptor activity GO:0004879 9.43 ESR1 ESR2 PGR
7 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
8 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
9 follicle-stimulating hormone receptor activity GO:0004963 9.16 FSHR LHCGR
10 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
11 steroid binding GO:0005496 8.92 ESR1 ESR2 PGR SHBG

Sources for Estrogen Excess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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