MCID: EST004
MIFTS: 40

Estrogen Excess

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Estrogen Excess

MalaCards integrated aliases for Estrogen Excess:

Name: Estrogen Excess 12 15
Hyperestrogenism 12 55 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14336
ICD10 33 E28.0
ICD9CM 35 256.0
NCIt 50 C113344
SNOMED-CT 68 37295009
UMLS 73 C0154209

Summaries for Estrogen Excess

Disease Ontology : 12 An ovarian dysfunction that is characterized by a higher than normal ratio of estrogen.

MalaCards based summary : Estrogen Excess, also known as hyperestrogenism, is related to aromatase excess syndrome and mccune-albright syndrome. An important gene associated with Estrogen Excess is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Signaling by ERBB4. The drugs Hormone Antagonists and Hormones, Hormone Substitutes, and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and breast, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Hyperestrogenism, hyperestrogenic state, or estrogen excess, is a medical condition characterized by an... more...

Related Diseases for Estrogen Excess

Diseases related to Estrogen Excess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 aromatase excess syndrome 33.1 CGNL1 CYP19A1
2 mccune-albright syndrome 31.7 CYP19A1 PRL
3 hyperandrogenism 31.6 CYP19A1 PRL SHBG
4 hyperprolactinemia 29.8 PRL SHBG
5 endometriosis 29.4 CYP19A1 ESR1 ESR2 PGR
6 polycystic ovary syndrome 29.3 CYP19A1 FSHR PRL SHBG
7 precocious puberty, male-limited 10.2 CYP19A1 FSHR
8 benign metastasizing leiomyoma 10.2 CYP19A1 PGR
9 endometrial stromal nodule 10.2 CYP19A1 PGR
10 hypogonadism, male 10.2
11 hypogonadism 10.2
12 hypoactive sexual desire disorder 10.2 CYP19A1 SHBG
13 androgen insensitivity, partial 10.2 CYP19A1 SHBG
14 alopecia, androgenetic, 1 10.1 CYP19A1 SHBG
15 sex cord-gonadal stromal tumor 10.1 CYP19A1 PGR
16 complete androgen insensitivity syndrome 10.1 CYP19A1 SHBG
17 intracystic papillary adenoma 10.1 PGR PRL
18 sella turcica neoplasm 10.1 PGR PRL
19 tuberculum sellae meningioma 10.1 PGR PRL
20 hypothyroidism, central, and testicular enlargement 10.1 CYP19A1 PRL
21 ovarian hyperstimulation syndrome 10.1 CYP19A1 FSHR
22 vestibular gland benign neoplasm 10.1 ESR1 PGR
23 bartholin's gland adenoma 10.1 ESR1 PGR
24 vulvar syringoma 10.1 ESR1 PGR
25 endometrial disease 10.1 CYP19A1 ESR1
26 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
27 lung leiomyoma 10.1 ESR1 PGR
28 vulvar benign neoplasm 10.1 ESR1 PGR
29 trigonitis 10.1 ESR1 PGR
30 vulvar leiomyoma 10.1 ESR1 PGR
31 predominantly cortical thymoma 10.1 ESR1 PGR
32 breast medullary carcinoma 10.1 ESR1 PGR
33 breast scirrhous carcinoma 10.1 ESR1 PGR
34 aromatase deficiency 10.1 CYP19A1 ESR1
35 bartholin's gland benign neoplasm 10.1 ESR1 PGR
36 oncocytic breast carcinoma 10.1 ESR1 PGR
37 endometrial squamous cell carcinoma 10.1 ESR1 PGR
38 cribriform carcinoma 10.1 ESR1 PGR
39 leydig cell tumor 10.1
40 sertoli-leydig cell tumor 10.1
41 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
42 adenoid basal cell carcinoma 10.1 ESR1 PGR
43 breast adenoid cystic carcinoma 10.1 ESR1 PGR
44 apocrine adenocarcinoma 10.1 ESR1 PGR
45 peritoneal benign neoplasm 10.1 ESR1 PGR
46 deep angioma 10.1 ESR1 PGR
47 diffuse peritoneal leiomyomatosis 10.1 ESR1 PGR
48 leiomyomatosis 10.1 ESR1 PGR
49 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
50 female reproductive endometrioid cancer 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Estrogen Excess:



Diseases related to Estrogen Excess

Symptoms & Phenotypes for Estrogen Excess

MGI Mouse Phenotypes related to Estrogen Excess:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR
2 homeostasis/metabolism MP:0005376 9.87 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR
3 endocrine/exocrine gland MP:0005379 9.85 CYP19A1 ESR1 ESR2 FSHR PGR PRL
4 immune system MP:0005387 9.8 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR
5 integument MP:0010771 9.63 CYP19A1 ESR1 ESR2 FSHR PGR PRL
6 neoplasm MP:0002006 9.35 ESR1 ESR2 FSHR PGR PRL
7 reproductive system MP:0005389 9.17 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR

Drugs & Therapeutics for Estrogen Excess

Drugs for Estrogen Excess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones, Hormone Substitutes, and Hormone Antagonists
3 Hormones
4 Estrogens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
2 Norwegian Adenomyosis Study I Completed NCT02201719
3 Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Active, not recruiting NCT02197923

Search NIH Clinical Center for Estrogen Excess

Genetic Tests for Estrogen Excess

Anatomical Context for Estrogen Excess

MalaCards organs/tissues related to Estrogen Excess:

41
Ovary, Lung, Breast, Prostate, Cervix, Smooth Muscle

Publications for Estrogen Excess

Articles related to Estrogen Excess:

(show all 33)
# Title Authors Year
1
Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. ( 29183089 )
2018
2
Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets. ( 30221009 )
2018
3
Biotin interference in immunoassays mimicking subclinical Graves' disease and hyperestrogenism: a case series. ( 27718482 )
2017
4
Right hepatectomy for giant hepatic hemangioma with progressive growth in a case of relative hyperestrogenism. ( 25986889 )
2016
5
Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-bacterial male accessory gland inflammation. ( 27091838 )
2016
6
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). ( 26001599 )
2015
7
Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? ( 23127146 )
2013
8
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. ( 20172968 )
2010
9
Iatrogenic androgen and estrogen excess in a postmenopausal woman presenting with facial erythema, acne, and hirsutism. ( 19702988 )
2009
10
Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. ( 15799627 )
2005
11
Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. ( 12736278 )
2003
12
Precocious puberty resulting from congenital hypothalamic hamartoma: persistent darkened areolae after birth as the hallmark of estrogen excess. ( 11307963 )
2001
13
How valid is the prenatal estrogen excess hypothesis of testicular germ cell cancer? A case control study on hormone-related factors. ( 11805417 )
2001
14
Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis. ( 11006024 )
2000
15
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. ( 9178751 )
1997
16
Case report of a malignant Brenner tumor with hyperestrogenism. ( 7704247 )
1995
17
Hyperestrogenism induced by menotropins alone or in conjunction with luprolide acetate in in vitro fertilization cycles: the impact on hemostasis. ( 7851588 )
1995
18
Male hypogonadism due to nontumorous hyperestrogenism. ( 2086575 )
1990
19
Considering hyperestrogenism as a cause of anemia. ( 2370209 )
1990
20
Male hypogonadism due to hyperestrogenism. ( 3941702 )
1986
21
Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. ( 3990735 )
1985
22
Postmenopausal ovarian follicle cyst: an unusual cause of estrogen excess. ( 6500803 )
1984
23
Role of estrogen receptor binding and transcriptional activity in the stimulation of hyperestrogenism and nuclear bodies. ( 275847 )
1978
24
Adrenal reactivity to ACTH in women with hyperestrogenism. ( 183263 )
1976
25
Hyperestrogenism by transplantable pulmonary tumors of mice. ( 5068617 )
1972
26
Hyperestrogenism in female swine as the result of feeding mouldy corn. ( 5104356 )
1971
27
Hyperestrogenism in children of employees of the Polfa pharmaceutical laboratories in Jelenia Góra. ( 6080881 )
1967
28
TEEN-AGE GYNECOLOGY. WITH SPECIAL REFERENCE TO VAGINAL HYPERESTROGENISM. ( 14151823 )
1964
29
"HYPERESTROGENISM"--PSYCHE AND SOMA IN TEEN-AGERS. ( 14162295 )
1964
30
Hyperestrogenism and its therapy; preliminary report. ( 14799527 )
1951
31
Hyperestrogenism treated with prolactin. ( 24537264 )
1950
32
Hyperestrogenism treated with lactogenic hormone. ( 18939215 )
1948
33
Cervical cancer; a disordered growth response to inflammation in the presence of estrogen excess and nutritional deficiency; cytological, clinical, nutritional, and pathologic studies. ( 20262967 )
1947

Variations for Estrogen Excess

Expression for Estrogen Excess

Search GEO for disease gene expression data for Estrogen Excess.

Pathways for Estrogen Excess

GO Terms for Estrogen Excess

Biological processes related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.61 ESR1 ESR2 PGR
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.54 ESR1 ESR2 PGR
3 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.48 ESR1 FSHR
4 steroid hormone mediated signaling pathway GO:0043401 9.46 ESR1 PGR
5 female gonad development GO:0008585 9.4 CYP19A1 FSHR
6 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ESR1 ESR2
7 androgen metabolic process GO:0008209 9.26 CYP19A1 ESR1
8 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.16 ESR1 FSHR
9 mammary gland development GO:0030879 9.13 CYP19A1 PGR PRL
10 uterus development GO:0060065 8.8 CYP19A1 ESR1 FSHR

Molecular functions related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.71 ESR1 ESR2 PGR SHBG
2 steroid hormone receptor activity GO:0003707 9.43 ESR1 ESR2 PGR
3 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
4 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
5 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
6 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
7 steroid binding GO:0005496 8.92 ESR1 ESR2 PGR SHBG

Sources for Estrogen Excess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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