MCID: EST004
MIFTS: 42

Estrogen Excess

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Estrogen Excess

MalaCards integrated aliases for Estrogen Excess:

Name: Estrogen Excess 12 15
Hyperestrogenism 12 56 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14336
ICD9CM 36 256.0
NCIt 51 C113344
SNOMED-CT 69 37295009
ICD10 34 E28.0
UMLS 74 C0154209

Summaries for Estrogen Excess

Disease Ontology : 12 An ovarian dysfunction that is characterized by a higher than normal ratio of estrogen.

MalaCards based summary : Estrogen Excess, also known as hyperestrogenism, is related to mccune-albright syndrome and aromatase excess syndrome. An important gene associated with Estrogen Excess is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Signaling by ERBB4. The drugs Tamoxifen and Estrogens have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Hyperestrogenism, hyperestrogenic state, or estrogen excess, is a medical condition characterized by an... more...

Related Diseases for Estrogen Excess

Diseases related to Estrogen Excess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 31.8 CYP19A1 PRL
2 aromatase excess syndrome 30.1 CGNL1 CYP19A1
3 hyperprolactinemia 29.7 PRL SHBG
4 polycystic ovary syndrome 29.2 CYP19A1 FSHR PRL SHBG
5 endometriosis 29.2 CYP19A1 ESR1 ESR2 PGR
6 precocious puberty, male-limited 10.4 CYP19A1 FSHR
7 benign metastasizing leiomyoma 10.3 CYP19A1 PGR
8 endometrial stromal nodule 10.3 CYP19A1 PGR
9 hypoactive sexual desire disorder 10.3 CYP19A1 SHBG
10 androgen insensitivity, partial 10.2 CYP19A1 SHBG
11 alopecia, androgenetic, 1 10.2 CYP19A1 SHBG
12 sex cord-gonadal stromal tumor 10.2 CYP19A1 PGR
13 complete androgen insensitivity syndrome 10.2 CYP19A1 SHBG
14 intracystic papillary adenoma 10.2 PGR PRL
15 hypogonadism, male 10.2
16 hypogonadism 10.2
17 hypogonadotropism 10.2
18 ovarian hyperstimulation syndrome 10.2 CYP19A1 FSHR
19 sella turcica neoplasm 10.2 PGR PRL
20 tuberculum sellae meningioma 10.2 PGR PRL
21 hypothyroidism, central, and testicular enlargement 10.2 CYP19A1 PRL
22 vestibular gland benign neoplasm 10.2 ESR1 PGR
23 bartholin's gland adenoma 10.2 ESR1 PGR
24 vulvar syringoma 10.2 ESR1 PGR
25 lung leiomyoma 10.2 ESR1 PGR
26 endometrial disease 10.2 CYP19A1 ESR1
27 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
28 vulvar benign neoplasm 10.1 ESR1 PGR
29 trigonitis 10.1 ESR1 PGR
30 vulvar leiomyoma 10.1 ESR1 PGR
31 predominantly cortical thymoma 10.1 ESR1 PGR
32 breast medullary carcinoma 10.1 ESR1 PGR
33 breast scirrhous carcinoma 10.1 ESR1 PGR
34 aromatase deficiency 10.1 CYP19A1 ESR1
35 bartholin's gland benign neoplasm 10.1 ESR1 PGR
36 oncocytic breast carcinoma 10.1 ESR1 PGR
37 endometrial squamous cell carcinoma 10.1 ESR1 PGR
38 cribriform carcinoma 10.1 ESR1 PGR
39 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
40 adenoid basal cell carcinoma 10.1 ESR1 PGR
41 apocrine adenocarcinoma 10.1 ESR1 PGR
42 peritoneal benign neoplasm 10.1 ESR1 PGR
43 deep angioma 10.1 ESR1 PGR
44 diffuse peritoneal leiomyomatosis 10.1 ESR1 PGR
45 leiomyomatosis 10.1 ESR1 PGR
46 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
47 breast adenoid cystic carcinoma 10.1 ESR1 PGR
48 female reproductive endometrioid cancer 10.1 ESR1 PGR
49 cervical carcinosarcoma 10.1 ESR1 PGR
50 intramuscular hemangioma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Estrogen Excess:



Diseases related to Estrogen Excess

Symptoms & Phenotypes for Estrogen Excess

MGI Mouse Phenotypes related to Estrogen Excess:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.88 CYP19A1 ESR1 ESR2 FSHR PGR PRL
2 homeostasis/metabolism MP:0005376 9.87 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR
3 endocrine/exocrine gland MP:0005379 9.85 CYP19A1 ESR1 ESR2 FSHR PGR PRL
4 immune system MP:0005387 9.8 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR
5 integument MP:0010771 9.63 CYP19A1 ESR1 ESR2 FSHR PGR PRL
6 neoplasm MP:0002006 9.35 ESR1 ESR2 FSHR PGR PRL
7 reproductive system MP:0005389 9.17 CYP19A1 ESR1 ESR2 FSHR KIAA1324 PGR

Drugs & Therapeutics for Estrogen Excess

Drugs for Estrogen Excess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved 10540-29-1 2733526
2 Estrogens
3 Hormone Antagonists
4 Hormones, Hormone Substitutes, and Hormone Antagonists
5 Hormones
6 Selective Estrogen Receptor Modulators
7 Steroid Synthesis Inhibitors
8 Bone Density Conservation Agents
9 Estrogen Receptor Antagonists
10 Aromatase Inhibitors
11 Antineoplastic Agents, Hormonal
12 Estrogen Antagonists
13 Estrogen Receptor Modulators

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
2 Norwegian Adenomyosis Study I Completed NCT02201719
3 Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Active, not recruiting NCT02197923
4 Endometrial Changes in Breast Cancer Women With or Without Hormonal Therapies Not yet recruiting NCT03898947

Search NIH Clinical Center for Estrogen Excess

Genetic Tests for Estrogen Excess

Anatomical Context for Estrogen Excess

MalaCards organs/tissues related to Estrogen Excess:

42
Breast, Ovary, Bone, Prostate, Liver, Heart, Smooth Muscle

Publications for Estrogen Excess

Articles related to Estrogen Excess:

(show all 42)
# Title Authors Year
1
Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. ( 30701446 )
2019
2
Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. ( 29183089 )
2018
3
Hyperestrogenism Affects Adult Height Outcome in Growth Hormone Treated Boys With Silver-Russell Syndrome. ( 30622515 )
2018
4
Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets. ( 30221009 )
2018
5
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
6
Biotin interference in immunoassays mimicking subclinical Graves' disease and hyperestrogenism: a case series. ( 27718482 )
2017
7
Right hepatectomy for giant hepatic hemangioma with progressive growth in a case of relative hyperestrogenism. ( 25986889 )
2016
8
Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-bacterial male accessory gland inflammation. ( 27091838 )
2016
9
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). ( 26001599 )
2015
10
Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? ( 23127146 )
2013
11
Hyperprolactinemia is not associated with hyperestrogenism in noncycling African elephants (Loxodonta africana). ( 23623777 )
2013
12
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
13
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. ( 20172968 )
2010
14
Iatrogenic androgen and estrogen excess in a postmenopausal woman presenting with facial erythema, acne, and hirsutism. ( 19702988 )
2009
15
Persistent hyperestrogenism after precocious puberty in young females with McCune-Albright syndrome. ( 17982390 )
2007
16
Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. ( 15799627 )
2005
17
Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. ( 12736278 )
2003
18
Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme. ( 12656667 )
2003
19
Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings. ( 12843139 )
2003
20
Precocious puberty resulting from congenital hypothalamic hamartoma: persistent darkened areolae after birth as the hallmark of estrogen excess. ( 11307963 )
2001
21
How valid is the prenatal estrogen excess hypothesis of testicular germ cell cancer? A case control study on hormone-related factors. ( 11805417 )
2001
22
Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis. ( 11006024 )
2000
23
The influence of hyperestrogenism during in vitro fertilization on the fibrinolytic mechanism. ( 9580312 )
1998
24
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. ( 9178751 )
1997
25
Case report of a malignant Brenner tumor with hyperestrogenism. ( 7704247 )
1995
26
Hyperestrogenism induced by menotropins alone or in conjunction with luprolide acetate in in vitro fertilization cycles: the impact on hemostasis. ( 7851588 )
1995
27
Male hypogonadism due to nontumorous hyperestrogenism. ( 2086575 )
1990
28
Considering hyperestrogenism as a cause of anemia. ( 2370209 )
1990
29
Male hypogonadism due to hyperestrogenism. ( 3941702 )
1986
30
Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. ( 3990735 )
1985
31
Postmenopausal ovarian follicle cyst: an unusual cause of estrogen excess. ( 6500803 )
1984
32
Role of estrogen receptor binding and transcriptional activity in the stimulation of hyperestrogenism and nuclear bodies. ( 275847 )
1978
33
Adrenal reactivity to ACTH in women with hyperestrogenism. ( 183263 )
1976
34
Hyperestrogenism by transplantable pulmonary tumors of mice. ( 5068617 )
1972
35
Hyperestrogenism in female swine as the result of feeding mouldy corn. ( 5104356 )
1971
36
Hyperestrogenism in children of employees of the Polfa pharmaceutical laboratories in Jelenia Góra. ( 6080881 )
1967
37
TEEN-AGE GYNECOLOGY. WITH SPECIAL REFERENCE TO VAGINAL HYPERESTROGENISM. ( 14151823 )
1964
38
"HYPERESTROGENISM"--PSYCHE AND SOMA IN TEEN-AGERS. ( 14162295 )
1964
39
Hyperestrogenism and its therapy; preliminary report. ( 14799527 )
1951
40
Hyperestrogenism treated with prolactin. ( 24537264 )
1950
41
Hyperestrogenism treated with lactogenic hormone. ( 18939215 )
1948
42
Cervical cancer; a disordered growth response to inflammation in the presence of estrogen excess and nutritional deficiency; cytological, clinical, nutritional, and pathologic studies. ( 20262967 )
1947

Variations for Estrogen Excess

Expression for Estrogen Excess

Search GEO for disease gene expression data for Estrogen Excess.

Pathways for Estrogen Excess

GO Terms for Estrogen Excess

Biological processes related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.54 ESR1 ESR2 PGR
2 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.48 ESR1 FSHR
3 steroid hormone mediated signaling pathway GO:0043401 9.46 ESR1 PGR
4 female gonad development GO:0008585 9.4 CYP19A1 FSHR
5 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ESR1 ESR2
6 androgen metabolic process GO:0008209 9.26 CYP19A1 ESR1
7 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.16 ESR1 FSHR
8 transcription, DNA-templated GO:0006351 9.13 ESR1
9 mammary gland development GO:0030879 9.13 CYP19A1 PGR PRL
10 uterus development GO:0060065 8.8 CYP19A1 ESR1 FSHR

Molecular functions related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.67 ESR1 ESR2 PGR SHBG
2 steroid hormone receptor activity GO:0003707 9.33 ESR1 ESR2 PGR
3 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
4 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
5 nuclear receptor activity GO:0004879 9.13 ESR1 ESR2 PGR
6 steroid binding GO:0005496 8.92 ESR1 ESR2 PGR SHBG

Sources for Estrogen Excess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....