MCID: EST004
MIFTS: 41

Estrogen Excess

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Estrogen Excess

MalaCards integrated aliases for Estrogen Excess:

Name: Estrogen Excess 12 15
Hyperestrogenism 12 54 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14336
ICD9CM 34 256.0
NCIt 49 C113344
SNOMED-CT 67 37295009
ICD10 32 E28.0
UMLS 71 C0154209

Summaries for Estrogen Excess

Disease Ontology : 12 An ovarian dysfunction that is characterized by a higher than normal ratio of estrogen.

MalaCards based summary : Estrogen Excess, also known as hyperestrogenism, is related to endometrial cancer and leydig cell tumor. An important gene associated with Estrogen Excess is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Relaxin signaling pathway and Glioma. The drugs Tamoxifen and Estrogens have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and liver, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Estrogen Excess

Diseases related to Estrogen Excess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 endometrial cancer 30.4 SULT1E1 SHBG PTEN PGR GNRH1 ESR2
2 leydig cell tumor 30.0 PRL GNRH1 ESR1 CYP19A1
3 hyperprolactinemia 30.0 SHBG PRL GNRH1
4 testicular germ cell cancer 29.8 FSHR ESR2 ESR1
5 germ cell cancer 29.8 FSHR ESR2 ESR1
6 hypogonadotropism 29.8 PRL GNRH1
7 hypogonadotropic hypogonadism 29.4 SHBG PRL GNRH1 CYP19A1
8 hypogonadism 29.4 SHBG PRL GNRH1 CYP19A1
9 ovarian cyst 29.3 PRL GNRH1 FOXL2 ESR2 CYP19A1
10 aromatase excess syndrome 29.3 SHBG GNRH1 ESR1 CYP19A1 CGNL1
11 anovulation 29.2 SHBG PRL GNRH1 FSHR CYP19A1
12 polycystic ovary syndrome 29.2 SHBG PRL GNRH1 FSHR CYP19A1
13 endometrial hyperplasia 28.9 PTEN PGR ESR2 ESR1 CYP19A1
14 endometriosis 28.8 PTEN PGR GNRH1 ESR2 ESR1 CYP19A1
15 amenorrhea 28.6 SHBG PRL GNRH1 FSHR FOXL2 CYP19A1
16 gynecomastia 28.4 SHBG PRL PGR GNRH1 ESR2 ESR1
17 precocious puberty, male-limited 10.5 FSHR CYP19A1
18 benign metastasizing leiomyoma 10.5 PGR CYP19A1
19 prostatic cyst 10.5 FSHR EPPIN
20 glassy cell carcinoma of the cervix 10.5 PGR ESR1
21 bartholin's gland adenoid cystic carcinoma 10.5 PGR ESR1
22 chronic tympanitis 10.5 PGR ESR1
23 bartholin's gland adenoma 10.5 PGR ESR1
24 granulomatous endometritis 10.5 PGR ESR1
25 bartholin's gland benign neoplasm 10.5 PGR ESR1
26 vestibular gland benign neoplasm 10.5 PGR ESR1
27 hypoactive sexual desire disorder 10.4 SHBG CYP19A1
28 breast juvenile papillomatosis 10.4 PGR ESR1
29 lung leiomyoma 10.4 PGR ESR1
30 vulvar syringoma 10.4 PGR ESR1
31 trigonitis 10.4 PGR ESR1
32 androgen insensitivity, partial 10.4 SHBG CYP19A1
33 breast scirrhous carcinoma 10.4 PGR ESR1
34 alopecia, androgenetic, 1 10.4 SHBG CYP19A1
35 oncocytic breast carcinoma 10.4 PGR ESR1
36 vagina leiomyosarcoma 10.4 PGR ESR1
37 ovarian seromucinous carcinoma 10.4 PGR ESR1
38 breast papillary carcinoma 10.4 PGR ESR1
39 breast leiomyoma 10.4 PGR ESR1
40 atrophic vulva 10.4 SHBG ESR1
41 intravenous leiomyomatosis 10.4 PGR ESR1
42 liver leiomyoma 10.4 PGR ESR1
43 comedo carcinoma 10.4 PGR ESR1
44 breast metaplastic carcinoma 10.4 PGR ESR1
45 vulvar leiomyoma 10.4 PGR ESR1
46 bizarre leiomyoma 10.4 PGR ESR1
47 lipid-rich breast carcinoma 10.4 PRL PGR
48 inhibited female orgasm 10.4 SHBG PRL
49 lipid-rich carcinoma 10.4 PGR ESR1
50 vaginal endometrial stromal sarcoma 10.4 PGR ESR1

Graphical network of the top 20 diseases related to Estrogen Excess:



Diseases related to Estrogen Excess

Symptoms & Phenotypes for Estrogen Excess

MGI Mouse Phenotypes related to Estrogen Excess:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CGNL1 CYP19A1 ESR1 ESR2 FOXL2 FSHR
2 endocrine/exocrine gland MP:0005379 10.22 CYP19A1 ESR1 ESR2 FOXL2 FSHR GNRH1
3 hematopoietic system MP:0005397 10.16 CYP19A1 ESR1 ESR2 FSHR GNRH1 GPER1
4 cardiovascular system MP:0005385 10.15 CYP19A1 ESR1 ESR2 FSHR GPER1 KIAA1324
5 immune system MP:0005387 10.1 CYP19A1 ESR1 ESR2 FSHR GNRH1 GPER1
6 integument MP:0010771 9.97 CYP19A1 ESR1 ESR2 FSHR GNRH1 PGR
7 limbs/digits/tail MP:0005371 9.87 ESR1 ESR2 FSHR GPER1 KIAA1324 PGR
8 liver/biliary system MP:0005370 9.8 CYP19A1 ESR1 ESR2 GNRH1 GPER1 PRL
9 reproductive system MP:0005389 9.73 CYP19A1 ESR1 ESR2 FOXL2 FSHR GNRH1
10 neoplasm MP:0002006 9.7 ESR1 ESR2 FSHR GNRH1 PGR PRL
11 skeleton MP:0005390 9.28 CYP19A1 ESR1 ESR2 FSHR GNRH1 GPER1

Drugs & Therapeutics for Estrogen Excess

Drugs for Estrogen Excess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved 10540-29-1 2733526
2 Estrogens
3 Selective Estrogen Receptor Modulators
4 Steroid Synthesis Inhibitors
5 Antineoplastic Agents, Hormonal
6 Estrogen Antagonists
7 Hormone Antagonists
8 Estrogen Receptor Antagonists
9 Estrogen Receptor Modulators
10 Aromatase Inhibitors
11 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Links Between Water and Salt Intake, Body Weight, Hypertension and Kidney Stones: a Difficult Puzzle Unknown status NCT01100580
2 Norwegian Adenomyosis Study: Pathophysiology, Peristalsis, Expression Profiling and Diagnostics, Part I Completed NCT02201719
3 Molecular Analysis of Estrogen Receptors in Patients With Chronic Venous Disease Completed NCT02558426
4 Norwegian Adenomyosis Study: Pathophysiology, Peristalsis, Expression Profiling and Diagnosis, Part 2 Active, not recruiting NCT02197923
5 Evaluation of Endometrial Changes in Breast Cancer Women With or Without Hormonal Therapies Not yet recruiting NCT03898947

Search NIH Clinical Center for Estrogen Excess

Genetic Tests for Estrogen Excess

Anatomical Context for Estrogen Excess

MalaCards organs/tissues related to Estrogen Excess:

40
Breast, Ovary, Liver, Pituitary, Kidney, Prostate, Thyroid

Publications for Estrogen Excess

Articles related to Estrogen Excess:

(show top 50) (show all 386)
# Title Authors PMID Year
1
[Familial precocious puberty -- a variant of norm or pathology?]. 61 54
16704862 2006
2
The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment. 54 61
16202169 2005
3
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. 54 61
14747944 2004
4
Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme. 61 54
12656667 2003
5
Sclerosing stromal tumor of the ovary in a postmenopausal woman with estrogen excess: A case report. 61
31764859 2019
6
FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. 61
31701078 2019
7
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. 61
31336362 2019
8
Sexual Dysfunction and Sex Hormone Abnormalities in Patients With Cirrhosis: Review of Pathogenesis and Management. 61
30468515 2019
9
Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. 61
30701446 2019
10
Adrenal Cortical Carcinoma Associated With Lynch Syndrome: A Case Report and Review of Literature. 61
30963136 2019
11
Female infertility: which role for obesity? 61
31391925 2019
12
Testosterone and Benign Prostatic Hyperplasia. 61
30803920 2019
13
Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma. 61
29210800 2019
14
Hypertrophic osteoarthropathy: estrogens, prostaglandinE2, prostaglandin A2, and the inflammatory reflex. 61
29480386 2019
15
Ovarian granulosa cell tumor and clomiphene citrate resistance. A case report and review of the literature. 61
30141889 2018
16
Short-Term and Long-Term Effects of Bisphenol A (BPA) Exposure During Breastfeeding on the Biochemical and Endocrine Profiles in Rats. 61
29883975 2018
17
Adult Granulosa Cell Tumor: A Sinister Differential for Clomiphene-resistant Infertility. 61
30158817 2018
18
FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. 61
29471425 2018
19
Long-term estradiol-17β exposure decreases the cholinergic innervation pattern of the pig ovary. 61
29305268 2018
20
Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. 61
29183089 2018
21
Survivin Expression in Simple Endometrial Polyps and Tamoxifen-associated Endometrial Polyps. 61
28319569 2018
22
Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets. 61
30221009 2018
23
Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome. 61
29854508 2018
24
Hyperestrogenism Affects Adult Height Outcome in Growth Hormone Treated Boys With Silver-Russell Syndrome. 61
30622515 2018
25
Ovarian hyperstimulation syndrome due to follicle-stimulating hormone-secreting pituitary adenomas. 61
28676954 2017
26
The Occurrence of Zearalenone in South Korean Feedstuffs between 2009 and 2016. 61
28714869 2017
27
Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review. 61
27565819 2017
28
Biotin interference in immunoassays mimicking subclinical Graves' disease and hyperestrogenism: a case series. 61
27718482 2017
29
Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature. 61
28438188 2017
30
[Fertility-sparing management of endometrial cancer and atypical hyperplasia]. 61
28368791 2017
31
Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. 61
28109061 2017
32
Gynecomastia and hormones. 61
27145756 2017
33
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. 61
28469526 2017
34
Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights. 61
28045098 2017
35
Activity of Zearalenone in the Porcine Intestinal Tract. 61
28029134 2016
36
Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis - Value of Autopsy in a Case Report. 61
27679759 2016
37
Clinicopathological Study of Uterine Leiomyomas: A Multicentric Study in Rural Population. 61
27651639 2016
38
Testosterone Aromatization to Estradiol in Course of Ovarian Functioning Brenner Tumor Associated With Endometrial Carcinoma and Endometriosis (Roncati-Manenti Triad). 61
27465894 2016
39
Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-bacterial male accessory gland inflammation. 61
27091838 2016
40
Developmental programming: postnatal estradiol modulation of prenatally organized reproductive neuroendocrine function in sheep. 61
27222598 2016
41
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. 61
27473538 2016
42
Right hepatectomy for giant hepatic hemangioma with progressive growth in a case of relative hyperestrogenism. 61
25986889 2016
43
Thyroid function and IVF outcome: when to investigate and when to intervene? 61
26967594 2016
44
ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. 61
26862996 2016
45
Giant Cavernous Hepatic Hemangioma Diagnosed Incidentally in a Perimenopausal Obese Female with Endometrial Adenocarcinoma: A Case Report. 61
26851037 2016
46
Defective DNA Mismatch Repair Influences Expression of Endometrial Carcinoma Biomarkers. 61
25851713 2016
47
Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. 61
26220752 2016
48
Estradiol-induced alopecia in five dogs after contact with a transdermal gel used for the treatment of postmenopausal symptoms in women. 61
26216160 2015
49
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). 61
26001599 2015
50
High estrogen in men after injectable testosterone therapy: the low T experience. 61
24928451 2015

Variations for Estrogen Excess

Expression for Estrogen Excess

Search GEO for disease gene expression data for Estrogen Excess.

Pathways for Estrogen Excess

GO Terms for Estrogen Excess

Biological processes related to Estrogen Excess according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 PTEN ESR2 ESR1
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.56 PTEN PGR ESR2 ESR1
3 steroid hormone mediated signaling pathway GO:0043401 9.5 PGR GPER1 ESR1
4 intracellular estrogen receptor signaling pathway GO:0030520 9.49 ESR2 ESR1
5 androgen metabolic process GO:0008209 9.48 ESR1 CYP19A1
6 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.46 FSHR ESR1
7 prostate gland growth GO:0060736 9.4 PTEN CYP19A1
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.37 GPER1 ESR1
9 mammary gland development GO:0030879 9.33 PRL PGR CYP19A1
10 female gonad development GO:0008585 9.13 FSHR FOXL2 CYP19A1
11 uterus development GO:0060065 8.92 FSHR FOXL2 ESR1 CYP19A1

Molecular functions related to Estrogen Excess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 PTEN PGR ESR2 ESR1
2 lipid binding GO:0008289 9.63 SULT1E1 SHBG PTEN PGR ESR2 ESR1
3 steroid hormone receptor activity GO:0003707 9.56 PGR GPER1 ESR2 ESR1
4 nuclear receptor activity GO:0004879 9.54 PGR ESR2 ESR1
5 estrogen response element binding GO:0034056 9.32 ESR2 ESR1
6 estrogen receptor activity GO:0030284 9.13 GPER1 ESR2 ESR1
7 steroid binding GO:0005496 9.1 SULT1E1 SHBG PGR GPER1 ESR2 ESR1

Sources for Estrogen Excess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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