MCID: ETH001
MIFTS: 39

Ethmoid Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Ethmoid Sinus Adenocarcinoma

MalaCards integrated aliases for Ethmoid Sinus Adenocarcinoma:

Name: Ethmoid Sinus Adenocarcinoma 12 15 73
Adenocarcinoma of the Ethmoid Sinus 12
Adenocarcinoma of Ethmoid Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2766
NCIt 50 C6237
UMLS 73 C1333472

Summaries for Ethmoid Sinus Adenocarcinoma

Disease Ontology : 12 An ethmoid sinus cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Ethmoid Sinus Adenocarcinoma, also known as adenocarcinoma of the ethmoid sinus, is related to adenocarcinoma and squamous cell carcinoma of the oral tongue, and has symptoms including pain and rhinorrhea. An important gene associated with Ethmoid Sinus Adenocarcinoma is CTTN (Cortactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Focal Adhesion. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include breast and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Ethmoid Sinus Adenocarcinoma

Diseases related to Ethmoid Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.2 CCND1 EGFR HRAS PIK3CA
2 squamous cell carcinoma of the oral tongue 10.4 CCND1 PIK3CA
3 apocrine adenoma 10.4 HRAS PIK3CA
4 prostate adenoid cystic carcinoma 10.4 HRAS PIK3CA
5 hemimegalencephaly 10.3 CCND1 PIK3CA
6 aggressive digital papillary adenocarcinoma 10.3 HRAS PIK3CA
7 nasal cavity adenocarcinoma 10.2 CXCL11 HRAS
8 nevus, epidermal 10.2 HRAS PIK3CA
9 prostate squamous cell carcinoma 10.2 HRAS PIK3CA
10 breast squamous cell carcinoma 10.2 EGFR PIK3CA
11 paronychia 10.0 EGFR HRAS
12 brain stem glioma 9.9 EGFR PIK3CA
13 retinal detachment 9.9
14 retinitis 9.9
15 cyclosporiasis 9.8 GGT1 GGT2
16 bladder urothelial carcinoma 9.8 CCND1 HRAS PIK3CA
17 algoneurodystrophy 9.8 GGT1 GGT2
18 adenoid cystic carcinoma 9.8 CCND1 HRAS PIK3CA
19 hidradenocarcinoma 9.8 CCND1 EGFR
20 spinal chordoma 9.8 EGFR PIK3CA
21 hepatic tuberculosis 9.8 GGT1 GGT2
22 estrogen-receptor positive breast cancer 9.8 CCND1 EGFR PIK3CA
23 bile duct carcinoma 9.7 CCND1 EGFR PIK3CA
24 lung adenoid cystic carcinoma 9.7 EGFR HRAS PIK3CA
25 acneiform dermatitis 9.7 EGFR HRAS PIK3CA
26 adenosquamous cell lung carcinoma 9.7 EGFR HRAS PIK3CA
27 malignant ovarian surface epithelial-stromal neoplasm 9.7 EGFR HRAS PIK3CA
28 ovary epithelial cancer 9.7 EGFR HRAS PIK3CA
29 uterine carcinosarcoma 9.7 EGFR HRAS PIK3CA
30 adamantinoma of long bones 9.6 CCND1 EGFR PIK3CA
31 cataract 31, multiple types 9.6 GGT1 GGT2
32 pancreatic cystadenocarcinoma 9.6 GGT1 GGT2
33 penile cancer 9.6 CCND1 EGFR HRAS
34 pre-malignant neoplasm 9.5 CCND1 EGFR
35 cell type cancer 9.5 CCND1 EGFR HRAS
36 lung squamous cell carcinoma 9.5 EGFR HRAS PIK3CA
37 glioblastoma multiforme 9.5 CCND1 EGFR PIK3CA
38 brain cancer 9.3 EGFR HRAS PIK3CA
39 periampullary adenoma 9.3 GGT1 GGT2 HRAS
40 colloid carcinoma of the pancreas 9.2 GGT1 GGT2 HRAS
41 female reproductive organ cancer 9.2 CCND1 EGFR HRAS PIK3CA
42 respiratory system cancer 9.2 CCND1 EGFR HRAS PIK3CA
43 gastrointestinal system cancer 9.2 CCND1 EGFR HRAS PIK3CA
44 pancreas adenocarcinoma 9.2 CCND1 EGFR HRAS PIK3CA
45 lung cancer susceptibility 3 9.1 CCND1 EGFR HRAS PIK3CA
46 gastric adenocarcinoma 9.1 CCND1 EGFR HRAS PIK3CA
47 nasopharyngeal carcinoma 9.1 CCND1 EGFR HRAS PIK3CA
48 glioblastoma 9.1 CCND1 EGFR HRAS PIK3CA
49 esophageal cancer 9.0 CCND1 EGFR HRAS PIK3CA
50 granulomatous hepatitis 9.0 GGT1 GGT2

Graphical network of the top 20 diseases related to Ethmoid Sinus Adenocarcinoma:



Diseases related to Ethmoid Sinus Adenocarcinoma

Symptoms & Phenotypes for Ethmoid Sinus Adenocarcinoma

UMLS symptoms related to Ethmoid Sinus Adenocarcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 EGFR HRAS PIK3CA
2 Decreased viability GR00221-A-1 9.47 EGFR HRAS PIK3CA
3 Decreased viability GR00221-A-2 9.47 HRAS PIK3CA
4 Decreased viability GR00221-A-3 9.47 HRAS
5 Decreased viability GR00221-A-4 9.47 PIK3CA EGFR
6 Decreased viability GR00402-S-2 9.47 EGFR HRAS PIK3CA

MGI Mouse Phenotypes related to Ethmoid Sinus Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 HRAS NDUFS3 CCND1 PIK3CA CTTN SNCA
2 growth/size/body region MP:0005378 9.92 GGT1 HRAS NDUFS3 CCND1 PIK3CA CTTN
3 endocrine/exocrine gland MP:0005379 9.85 SNCA EGFR GGT1 HRAS CCND1 PIK3CA
4 integument MP:0010771 9.73 GGT1 HRAS CCND1 PIK3CA SNCA EGFR
5 no phenotypic analysis MP:0003012 9.55 SNCA EGFR HRAS PIK3CA CTTN
6 reproductive system MP:0005389 9.43 EGFR GGT1 CCND1 PIK3CA CTTN SNCA
7 skeleton MP:0005390 9.1 EGFR GGT1 HRAS CCND1 PIK3CA SNCA

Drugs & Therapeutics for Ethmoid Sinus Adenocarcinoma

Drugs for Ethmoid Sinus Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanisms of Cancerogenesis of Woodworkers Adenocarcinomas Completed NCT02818231

Search NIH Clinical Center for Ethmoid Sinus Adenocarcinoma

Genetic Tests for Ethmoid Sinus Adenocarcinoma

Anatomical Context for Ethmoid Sinus Adenocarcinoma

MalaCards organs/tissues related to Ethmoid Sinus Adenocarcinoma:

41
Breast, Liver

Publications for Ethmoid Sinus Adenocarcinoma

Articles related to Ethmoid Sinus Adenocarcinoma:

# Title Authors Year
1
Liver metastasis of ethmoid sinus adenocarcinoma. ( 25577139 )
2015
2
Advanced ethmoid sinus adenocarcinoma presenting as temporary exudative retinal detachment. ( 23898291 )
2013
3
Leptomeningeal carcinomatosis from ethmoid sinus adenocarcinoma. ( 23273418 )
2012
4
Survival for ethmoid sinus adenocarcinoma in European populations. ( 19363711 )
2009
5
Amplification of CCND1, EMS1, PIK3CA, and ERBB oncogenes in ethmoid sinus adenocarcinomas. ( 16815198 )
2006
6
Leptomeningeal metastases from ethmoid sinus adenocarcinoma: clinico-radiological correlation. ( 10670169 )
1999
7
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. ( 10421261 )
1999
8
Cisplatin-based neoadjuvant chemotherapy and combined resection for ethmoid sinus adenocarcinoma reaching and/or invading the skull base. ( 8663951 )
1996
9
Orbital presentation of ethmoid sinus adenocarcinoma. ( 8751129 )
1995
10
Ethmoid sinus adenocarcinoma metastatic to breast. ( 7311554 )
1981

Variations for Ethmoid Sinus Adenocarcinoma

Expression for Ethmoid Sinus Adenocarcinoma

Search GEO for disease gene expression data for Ethmoid Sinus Adenocarcinoma.

Pathways for Ethmoid Sinus Adenocarcinoma

Pathways related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 CCND1 EGFR HRAS PIK3CA
2
Show member pathways
12.76 CCND1 EGFR HRAS PIK3CA
3
Show member pathways
12.74 CCND1 CXCL11 HRAS PIK3CA
4
Show member pathways
12.72 CCND1 EGFR HRAS PIK3CA
5 12.68 CCND1 EGFR HRAS PIK3CA
6
Show member pathways
12.61 CCND1 EGFR HRAS PIK3CA
7
Show member pathways
12.6 CCND1 EGFR HRAS PIK3CA
8
Show member pathways
12.5 CCND1 EGFR HRAS PIK3CA
9
Show member pathways
12.42 CCND1 EGFR HRAS PIK3CA
10
Show member pathways
12.33 CCND1 EGFR HRAS PIK3CA
11 12.29 CCND1 EGFR HRAS PIK3CA
12
Show member pathways
12.28 EGFR HRAS PIK3CA
13
Show member pathways
12.24 CCND1 EGFR HRAS PIK3CA
14
Show member pathways
12.21 CCND1 HRAS PIK3CA
15
Show member pathways
12.2 EGFR HRAS PIK3CA
16 12.17 CCND1 HRAS PIK3CA
17 12.04 CCND1 HRAS PIK3CA
18
Show member pathways
12.01 EGFR HRAS PIK3CA
19
Show member pathways
11.99 CCND1 EGFR HRAS PIK3CA
20 11.92 EGFR HRAS PIK3CA
21
Show member pathways
11.91 CCND1 EGFR HRAS
22
Show member pathways
11.88 CCND1 HRAS PIK3CA
23 11.86 CCND1 EGFR HRAS PIK3CA
24 11.83 CCND1 HRAS PIK3CA
25 11.82 CCND1 HRAS PIK3CA
26 11.8 CCND1 EGFR HRAS
27
Show member pathways
11.78 EGFR HRAS PIK3CA
28 11.77 EGFR HRAS PIK3CA
29 11.73 CCND1 HRAS PIK3CA
30
Show member pathways
11.72 CCND1 EGFR HRAS PIK3CA
31
Show member pathways
11.68 EGFR HRAS PIK3CA
32 11.52 CCND1 EGFR HRAS
33 11.45 EGFR HRAS PIK3CA
34
Show member pathways
11.4 CCND1 EGFR HRAS PIK3CA
35 11.36 CTTN EGFR HRAS
36 11.32 CCND1 CTTN EGFR HRAS PIK3CA
37 11.3 HRAS PIK3CA
38 11.25 CXCL11 PIK3CA
39 11.24 EGFR PIK3CA
40 11.23 CTTN PIK3CA
41 11.21 CCND1 PIK3CA
42 11.18 EGFR HRAS
43 11.18 HRAS PIK3CA
44 11.14 HRAS PIK3CA
45 11.12 EGFR PIK3CA
46
Show member pathways
11.1 EGFR HRAS
47 11.07 EGFR PIK3CA
48 11.05 GGT1 GGT2
49 11.03 GGT1 GGT2
50 11.03 CCND1 HRAS

GO Terms for Ethmoid Sinus Adenocarcinoma

Cellular components related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.92 EGFR GGT2 HRAS SNCA

Biological processes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.7 CCND1 EGFR HRAS
2 negative regulation of neuron apoptotic process GO:0043524 9.67 HRAS PIK3CA SNCA
3 membrane organization GO:0061024 9.65 CTTN EGFR SNCA
4 liver regeneration GO:0097421 9.55 CCND1 EGFR
5 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.54 CXCL11 SNCA
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS SNCA
7 liver development GO:0001889 9.5 CCND1 EGFR PIK3CA
8 zymogen activation GO:0031638 9.46 GGT1 GGT2
9 response to magnesium ion GO:0032026 9.43 CCND1 SNCA
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 EGFR PIK3CA SNCA
11 glutathione catabolic process GO:0006751 9.4 GGT1 GGT2
12 leukotriene D4 biosynthetic process GO:1901750 9.37 GGT1 GGT2
13 epidermal growth factor receptor signaling pathway GO:0007173 9.33 EGFR HRAS PIK3CA
14 response to UV-A GO:0070141 8.96 CCND1 EGFR
15 ERBB2 signaling pathway GO:0038128 8.8 EGFR HRAS PIK3CA

Molecular functions related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Ethmoid Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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