MCID: ETH001
MIFTS: 38

Ethmoid Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Ethmoid Sinus Adenocarcinoma

MalaCards integrated aliases for Ethmoid Sinus Adenocarcinoma:

Name: Ethmoid Sinus Adenocarcinoma 12 15 73
Adenocarcinoma of the Ethmoid Sinus 12
Adenocarcinoma of Ethmoid Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2766
NCIt 50 C6237
UMLS 73 C1333472

Summaries for Ethmoid Sinus Adenocarcinoma

Disease Ontology : 12 An ethmoid sinus cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Ethmoid Sinus Adenocarcinoma, also known as adenocarcinoma of the ethmoid sinus, is related to adenocarcinoma and squamous cell carcinoma of the oral tongue, and has symptoms including pain and rhinorrhea. An important gene associated with Ethmoid Sinus Adenocarcinoma is NDUFS3 (NADH:Ubiquinone Oxidoreductase Core Subunit S3), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and MicroRNAs in cancer. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include liver, breast and lung, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Ethmoid Sinus Adenocarcinoma

Diseases related to Ethmoid Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.6 CCND1 HRAS PIK3CA
2 squamous cell carcinoma of the oral tongue 10.1 CCND1 PIK3CA
3 hemimegalencephaly 10.1 CCND1 PIK3CA
4 apocrine adenoma 10.1 HRAS PIK3CA
5 prostate adenoid cystic carcinoma 10.1 HRAS PIK3CA
6 aggressive digital papillary adenocarcinoma 10.1 HRAS PIK3CA
7 lung adenoid cystic carcinoma 10.1 HRAS PIK3CA
8 acneiform dermatitis 10.0 HRAS PIK3CA
9 adenosquamous lung carcinoma 10.0 HRAS PIK3CA
10 penile cancer 10.0 CCND1 PIK3CA
11 nasal cavity adenocarcinoma 10.0 CXCL11 HRAS
12 ovary adenocarcinoma 10.0 HRAS PIK3CA
13 skin squamous cell carcinoma 10.0 HRAS PIK3CA
14 papilloma 10.0
15 papillary adenocarcinoma 10.0
16 inverted papilloma 10.0
17 retinal detachment 10.0
18 malignant ovarian surface epithelial-stromal neoplasm 10.0 HRAS PIK3CA
19 ovary epithelial cancer 10.0 HRAS PIK3CA
20 intestinal benign neoplasm 10.0 CCND1 HRAS
21 cyclosporiasis 9.9 GGT1 GGT2
22 algoneurodystrophy 9.9 GGT1 GGT2
23 pancreatic cystadenocarcinoma 9.9 GGT1 GGT2
24 hepatic tuberculosis 9.9 GGT1 GGT2
25 cataract 31, multiple types 9.9 GGT1 GGT2
26 autoimmune disease of urogenital tract 9.9 GGT1 GGT2
27 vertebrobasilar insufficiency 9.9 GGT1 GGT2
28 cholangiocarcinoma 9.9 CCND1 GGT1 PIK3CA
29 nevus, epidermal 9.9 HRAS PIK3CA
30 respiratory system cancer 9.9 CCND1 HRAS PIK3CA
31 intestinal disease 9.9 CCND1 HRAS PIK3CA
32 gastrointestinal system cancer 9.9 CCND1 HRAS PIK3CA
33 pancreas adenocarcinoma 9.9 CCND1 HRAS PIK3CA
34 bladder urothelial carcinoma 9.9 CCND1 HRAS PIK3CA
35 urinary tract obstruction 9.8 GGT1 PIK3CA
36 bile duct disease 9.8 GGT1 GGT2
37 large intestine cancer 9.8 CCND1 HRAS PIK3CA
38 adenoid cystic carcinoma 9.8 CCND1 CTTN HRAS PIK3CA
39 squamous cell carcinoma, head and neck 9.8 CCND1 CTTN HRAS PIK3CA
40 squamous cell carcinoma 9.8 CCND1 CTTN HRAS PIK3CA
41 nasopharyngeal carcinoma 9.7 CCND1 HRAS PIK3CA
42 periampullary adenoma 9.7 GGT1 GGT2 HRAS
43 colloid carcinoma of the pancreas 9.7 GGT1 GGT2 HRAS
44 pancreatic cancer 9.6 CCND1 GGT1 HRAS PIK3CA
45 hepatocellular carcinoma 9.5 CCND1 CTTN GGT1 HRAS PIK3CA
46 gastrointestinal system disease 9.5 CCND1 GGT1 GGT2 HRAS
47 ethmoid sinus cancer 8.8 CCND1 CTTN CXCL11 GGT1 GGT2 HRAS

Graphical network of the top 20 diseases related to Ethmoid Sinus Adenocarcinoma:



Diseases related to Ethmoid Sinus Adenocarcinoma

Symptoms & Phenotypes for Ethmoid Sinus Adenocarcinoma

UMLS symptoms related to Ethmoid Sinus Adenocarcinoma:


pain, rhinorrhea

MGI Mouse Phenotypes related to Ethmoid Sinus Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CCND1 CTTN HRAS NDUFS3 PIK3CA SNCA
2 growth/size/body region MP:0005378 9.17 CCND1 CTTN GGT1 HRAS NDUFS3 PIK3CA

Drugs & Therapeutics for Ethmoid Sinus Adenocarcinoma

Drugs for Ethmoid Sinus Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanisms of Cancerogenesis of Woodworkers Adenocarcinomas Completed NCT02818231

Search NIH Clinical Center for Ethmoid Sinus Adenocarcinoma

Genetic Tests for Ethmoid Sinus Adenocarcinoma

Anatomical Context for Ethmoid Sinus Adenocarcinoma

MalaCards organs/tissues related to Ethmoid Sinus Adenocarcinoma:

41
Liver, Breast, Lung, Colon, Tongue, Ovary, Pancreas

Publications for Ethmoid Sinus Adenocarcinoma

Articles related to Ethmoid Sinus Adenocarcinoma:

(show all 15)
# Title Authors Year
1
Liver metastasis of ethmoid sinus adenocarcinoma. ( 25577139 )
2015
2
Advanced ethmoid sinus adenocarcinoma presenting as temporary exudative retinal detachment. ( 23898291 )
2013
3
Leptomeningeal carcinomatosis from ethmoid sinus adenocarcinoma. ( 23273418 )
2012
4
Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: a retrospective study of 153 cases. ( 20665741 )
2011
5
Adenocarcinoma of the ethmoid sinus: retrospective study of 42 cases. ( 21616740 )
2011
6
Survival for ethmoid sinus adenocarcinoma in European populations. ( 19363711 )
2009
7
Leptomeningeal metastases from ethmoid sinus adenocarcinoma: clinico-radiological correlation. ( 10670169 )
1999
8
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. ( 10421261 )
1999
9
Cisplatin-based neoadjuvant chemotherapy and combined resection for ethmoid sinus adenocarcinoma reaching and/or invading the skull base. ( 8663951 )
1996
10
Orbital presentation of ethmoid sinus adenocarcinoma. ( 8751129 )
1995
11
Adenocarcinoma of the ethmoid sinus. ( 7672971 )
1995
12
Ethmoid sinus adenocarcinoma metastatic to breast. ( 7311554 )
1981
13
Adenocarcinoma of the ethmoid sinus; report of an unusual case. ( 13112365 )
1953
14
Adenocarcinoma of the ethmoid sinus. ( 20243504 )
1947
15
Adenocarcinoma of the ethmoid sinus. ( 21014588 )
1946

Variations for Ethmoid Sinus Adenocarcinoma

Expression for Ethmoid Sinus Adenocarcinoma

Search GEO for disease gene expression data for Ethmoid Sinus Adenocarcinoma.

Pathways for Ethmoid Sinus Adenocarcinoma

Pathways related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 CCND1 CXCL11 HRAS PIK3CA
2 12.33 CCND1 HRAS PIK3CA
3
Show member pathways
12.29 CCND1 HRAS PIK3CA
4
Show member pathways
12.28 CCND1 HRAS PIK3CA
5
Show member pathways
12.23 CCND1 HRAS PIK3CA
6
Show member pathways
12.21 CCND1 HRAS PIK3CA
7 12.21 CCND1 HRAS PIK3CA
8
Show member pathways
12.18 CCND1 HRAS PIK3CA
9
Show member pathways
12.09 CCND1 HRAS PIK3CA
10
Show member pathways
12.08 CCND1 HRAS PIK3CA
11 12.04 CCND1 HRAS PIK3CA
12
Show member pathways
12 CCND1 HRAS PIK3CA
13 11.87 CCND1 HRAS PIK3CA
14 11.86 CCND1 HRAS PIK3CA
15
Show member pathways
11.77 CCND1 HRAS PIK3CA
16
Show member pathways
11.72 CCND1 HRAS PIK3CA
17 11.56 CCND1 HRAS PIK3CA
18 11.56 CCND1 CTTN HRAS PIK3CA
19 11.49 CCND1 HRAS PIK3CA
20 11.34 CTTN PIK3CA
21 11.33 CCND1 HRAS PIK3CA
22
Show member pathways
11.31 GGT1 GGT2
23 11.29 HRAS PIK3CA
24
Show member pathways
11.23 CCND1 HRAS PIK3CA
25 11.22 HRAS PIK3CA
26 11.21 HRAS PIK3CA
27 11.15 CXCL11 PIK3CA
28 11.13 CTTN PIK3CA
29 11.11 CCND1 PIK3CA
30 11.09 HRAS PIK3CA
31 11.07 HRAS PIK3CA
32 11.01 HRAS PIK3CA
33 10.93 GGT1 GGT2
34 10.89 GGT1 GGT2
35 10.87 CCND1 HRAS
36 10.71 HRAS PIK3CA
37 10.32 CCND1 CTTN PIK3CA
38 10.12 HRAS PIK3CA

GO Terms for Ethmoid Sinus Adenocarcinoma

Biological processes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.67 GGT1 GGT2 SNCA
2 negative regulation of neuron apoptotic process GO:0043524 9.61 HRAS PIK3CA SNCA
3 cellular amino acid metabolic process GO:0006520 9.56 GGT1 GGT2
4 glutathione metabolic process GO:0006749 9.55 GGT1 GGT2
5 response to tumor necrosis factor GO:0034612 9.54 GGT1 GGT2
6 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.52 CXCL11 SNCA
7 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS SNCA
8 response to estradiol GO:0032355 9.5 CCND1 GGT1 GGT2
9 glutamate metabolic process GO:0006536 9.48 GGT1 GGT2
10 zymogen activation GO:0031638 9.46 GGT1 GGT2
11 response to magnesium ion GO:0032026 9.4 CCND1 SNCA
12 glutathione catabolic process GO:0006751 9.37 GGT1 GGT2
13 leukotriene D4 biosynthetic process GO:1901750 9.26 GGT1 GGT2
14 cysteine biosynthetic process GO:0019344 9.16 GGT1 GGT2
15 regulation of immune system process GO:0002682 8.96 GGT1 GGT2
16 peptide modification GO:0031179 8.62 GGT1 GGT2

Molecular functions related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.96 GGT1 GGT2
2 peptidyltransferase activity GO:0000048 8.62 GGT1 GGT2

Sources for Ethmoid Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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