MCID: ETH001
MIFTS: 37

Ethmoid Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Ethmoid Sinus Adenocarcinoma

MalaCards integrated aliases for Ethmoid Sinus Adenocarcinoma:

Name: Ethmoid Sinus Adenocarcinoma 12 15 70
Adenocarcinoma of the Ethmoid Sinus 12
Adenocarcinoma of Ethmoid Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2766
NCIt 50 C6237
UMLS 70 C1333472

Summaries for Ethmoid Sinus Adenocarcinoma

Disease Ontology : 12 An ethmoid sinus cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Ethmoid Sinus Adenocarcinoma, also known as adenocarcinoma of the ethmoid sinus, is related to papilloma and adenocarcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Ethmoid Sinus Adenocarcinoma is CTTN (Cortactin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include breast, lung and colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Ethmoid Sinus Adenocarcinoma

Diseases related to Ethmoid Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 papilloma 30.1 KRAS ERBB2 EGFR CCND1
2 adenocarcinoma 29.8 PIK3CA KRAS HRAS ERBB2 EGFR CDX2
3 hepatic flexure cancer 10.4 KRAS HRAS
4 trachea carcinoma in situ 10.3 KRAS HRAS
5 signet ring basal cell carcinoma 10.3 KRAS HRAS
6 cobblestone retinal degeneration 10.3 KRAS HRAS
7 immature teratoma of ovary 10.3 KRAS HRAS
8 pancreatic signet ring cell adenocarcinoma 10.3 KRAS HRAS
9 pancreatic foamy gland adenocarcinoma 10.3 CDX2 CCND1
10 laryngeal mucoepidermoid carcinoma 10.3 ERBB2 CDX2
11 ampulla of vater benign neoplasm 10.3 KRAS HRAS
12 sigmoid neoplasm 10.3 KRAS CDX2
13 vulva adenocarcinoma 10.3 ERBB2 CDX2
14 ethmoid sinus cancer 10.3 HRAS CTTN CDX2
15 transverse colon cancer 10.3 KRAS HRAS
16 periampullary adenoma 10.3 KRAS HRAS
17 bone giant cell sarcoma 10.3 KRAS HRAS
18 gallbladder benign neoplasm 10.3 KRAS HRAS
19 mucinous lung adenocarcinoma 10.3 KRAS HRAS
20 wolffian duct adenocarcinoma 10.3 KRAS HRAS
21 ovarian clear cell adenofibroma 10.3 PIK3CA KRAS
22 descending colon cancer 10.3 KRAS HRAS CDX2
23 appendiceal neoplasm 10.3 KRAS HRAS CDX2
24 appendix adenocarcinoma 10.3 KRAS HRAS CDX2
25 ascending colon cancer 10.3 KRAS HRAS CDX2
26 ovarian mucinous neoplasm 10.3 KRAS HRAS CDX2
27 noonan syndrome-like disorder with loose anagen hair 1 10.3 KRAS HRAS
28 malignant exocrine pancreas neoplasm 10.3 KRAS HRAS CDX2
29 appendix disease 10.2 KRAS HRAS CDX2
30 esophagus verrucous carcinoma 10.2 EGFR CCND1
31 gastric diffuse adenocarcinoma 10.2 ERBB2 CDX2
32 myh-associated polyposis 10.2 KRAS HRAS
33 appendix cancer 10.2 KRAS HRAS CDX2
34 duodenum adenocarcinoma 10.2 KRAS HRAS CDX2
35 breast scirrhous carcinoma 10.2 ERBB2 EGFR
36 rectosigmoid cancer 10.2 KRAS HRAS CDX2
37 duodenum cancer 10.2 KRAS HRAS CDX2
38 duodenum disease 10.2 KRAS HRAS CDX2
39 epiglottis neoplasm 10.2 PIK3CA CCND1
40 linitis plastica 10.2 ERBB2 CDX2
41 villous adenoma 10.2 KRAS HRAS CDX2
42 biliary tract benign neoplasm 10.2 KRAS HRAS
43 esophageal adenosquamous carcinoma 10.2 ERBB2 CDX2
44 breast juvenile papillomatosis 10.2 PIK3CA ERBB2
45 breast metaplastic carcinoma 10.2 ERBB2 EGFR
46 acneiform dermatitis 10.2 KRAS HRAS EGFR
47 adenocarcinoma in situ 10.2 KRAS EGFR CDX2
48 submandibular gland cancer 10.2 ERBB2 EGFR
49 bone squamous cell carcinoma 10.2 EGFR CTTN CCND1
50 lung carcinoma in situ 10.2 KRAS HRAS EGFR

Graphical network of the top 20 diseases related to Ethmoid Sinus Adenocarcinoma:



Diseases related to Ethmoid Sinus Adenocarcinoma

Symptoms & Phenotypes for Ethmoid Sinus Adenocarcinoma

UMLS symptoms related to Ethmoid Sinus Adenocarcinoma:


pain; rhinorrhea

GenomeRNAi Phenotypes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.68 EGFR HRAS KRAS PIK3CA
2 Decreased viability GR00055-A-2 9.68 EGFR HRAS KRAS PIK3CA
3 Decreased viability GR00055-A-3 9.68 KRAS
4 Decreased viability GR00106-A-0 9.68 KRAS
5 Decreased viability GR00221-A-1 9.68 EGFR HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-2 9.68 HRAS KRAS PIK3CA
7 Decreased viability GR00221-A-3 9.68 HRAS
8 Decreased viability GR00221-A-4 9.68 EGFR PIK3CA
9 Decreased viability GR00301-A 9.68 KRAS
10 Decreased viability GR00381-A-1 9.68 KRAS
11 Decreased viability GR00402-S-2 9.68 PIK3CA
12 Decreased cell migration GR00055-A-3 9.13 EGFR HRAS PIK3CA

MGI Mouse Phenotypes related to Ethmoid Sinus Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ACSL5 CCND1 CDX2 CLU CTTN EGFR
2 homeostasis/metabolism MP:0005376 10.18 ACSL5 ADAMTS13 CCND1 CDX2 CLU EGFR
3 mortality/aging MP:0010768 10.1 ADAMTS13 CCND1 CCT5 CDX2 CTTN EGFR
4 embryo MP:0005380 10.06 CCT5 CDX2 CTTN EGFR ERBB2 KRAS
5 digestive/alimentary MP:0005381 9.98 CCND1 CDX2 EGFR ERBB2 HRAS KRAS
6 neoplasm MP:0002006 9.8 CCND1 CDX2 EGFR ERBB2 HRAS KRAS
7 normal MP:0002873 9.76 ADAMTS13 CCND1 CDX2 EGFR ERBB2 HRAS
8 respiratory system MP:0005388 9.5 CCND1 CTTN EGFR ERBB2 HRAS KRAS
9 skeleton MP:0005390 9.28 ACSL5 CCND1 CDX2 EGFR ERBB2 HRAS

Drugs & Therapeutics for Ethmoid Sinus Adenocarcinoma

Drugs for Ethmoid Sinus Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanisms of Cancerogenesis for Woodworkers Adenocarcinomas: Transcriptional Study of Olfactory Cleft Cells of Patients Exposed or Not to Wood Dust Completed NCT02818231

Search NIH Clinical Center for Ethmoid Sinus Adenocarcinoma

Genetic Tests for Ethmoid Sinus Adenocarcinoma

Anatomical Context for Ethmoid Sinus Adenocarcinoma

MalaCards organs/tissues related to Ethmoid Sinus Adenocarcinoma:

40
Breast, Lung, Colon, Thyroid, Skin, Ovary, Appendix

Publications for Ethmoid Sinus Adenocarcinoma

Articles related to Ethmoid Sinus Adenocarcinoma:

(show all 32)
# Title Authors PMID Year
1
Nonintestinal Type Adenocarcinoma of the Ethmoid Sinus With Unusual Cribriform Histologic Pattern. 61
32732540 2020
2
[Chronic superficial urticaria associated with solid cancers: Case report and literature review]. 61
30905387 2019
3
Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma. 61
27363404 2016
4
[Nasal cavity and paranasal sinus cancer]. 61
27528562 2016
5
Liver metastasis of ethmoid sinus adenocarcinoma. 61
25577139 2015
6
Leptomeningeal carcinomatosis from ethmoid sinus adenocarcinoma. 61
23273418 2014
7
Advanced ethmoid sinus adenocarcinoma presenting as temporary exudative retinal detachment. 61
23898291 2013
8
Adenocarcinoma of the ethmoid sinus: retrospective study of 42 cases. 61
21616740 2011
9
Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: a retrospective study of 153 cases. 61
20665741 2011
10
[A case of advanced adenocarcinoma of the ethmoid sinus treated by chemoradiation with S-1]. 61
19461198 2009
11
Survival for ethmoid sinus adenocarcinoma in European populations. 61
19363711 2009
12
Is ethmoidal adenocarcinoma screening in employees exposed to wood dust justified? 61
19408499 2008
13
Amplification of CCND1, EMS1, PIK3CA, and ERBB oncogenes in ethmoid sinus adenocarcinomas. 61
16815198 2006
14
Comparative genomic hybridization in primary sinonasal adenocarcinomas. 61
14716769 2004
15
Leptomeningeal metastases from ethmoid sinus adenocarcinoma: clinico-radiological correlation. 61
10670169 1999
16
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. 61
10421261 1999
17
Endoscopic management of low-grade papillary adenocarcinoma of the ethmoid sinus: case report and review of the literature. 61
10326758 1999
18
[Adenocarcinoma of the ethmoid sinus in woodworkers. Retrospective study of 25 cases]. 61
9296054 1997
19
Cisplatin-based neoadjuvant chemotherapy and combined resection for ethmoid sinus adenocarcinoma reaching and/or invading the skull base. 61
8663951 1996
20
Orbital presentation of ethmoid sinus adenocarcinoma. 61
8751129 1995
21
Adenocarcinoma of the ethmoid sinus. 61
7672971 1995
22
Adenocarcinoma of the ethmoid sinuses in High Wycombe 1986. 61
2607203 1989
23
[Adenocarcinoma of the ethmoid sinus in a woodworker: apropos of a case]. 61
2799328 1989
24
Spinal cord compression due to ethmoid adenocarcinoma. 61
3652013 1987
25
Pathologic quiz case 1. Nasal papillomatosis (inverted papilloma); adenocarcinoma of the ethmoid sinus resembling colonic carcinoma. 61
3566957 1987
26
[Combined ORL and neurosurgical approach in adenocarcinoma of the ethmoid. Preliminary results apropos of 15 cases]. 61
3688740 1987
27
Carcinoma of the paranasal sinuses. Results of a prospective pilot study. 61
4005793 1985
28
Ethmoid sinus adenocarcinoma metastatic to breast. 61
7311554 1981
29
Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma. 61
6766200 1980
30
Adenocarcinoma of the ethmoid sinus; report of an unusual case. 61
13112365 1953
31
Adenocarcinoma of the ethmoid sinus. 61
20243504 1947
32
Adenocarcinoma of the ethmoid sinus. 61
21014588 1946

Variations for Ethmoid Sinus Adenocarcinoma

Expression for Ethmoid Sinus Adenocarcinoma

Search GEO for disease gene expression data for Ethmoid Sinus Adenocarcinoma.

Pathways for Ethmoid Sinus Adenocarcinoma

Pathways related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 UBC REL PIK3CA KRAS HRAS ERBB2
2
Show member pathways
13.38 UBC PIK3CA KRAS HRAS ERBB2 EGFR
3
Show member pathways
13.23 PIK3CA KRAS HRAS EGFR CXCL11 CCND1
4
Show member pathways
13.01 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
5
Show member pathways
12.97 UBC PIK3CA KRAS HRAS EGFR CCND1
6
Show member pathways
12.92 PIK3CA KRAS HRAS CXCL11 CCND1
7
Show member pathways
12.92 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
8
Show member pathways
12.9 PIK3CA KRAS HRAS ERBB2 EGFR
9 12.86 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
10
Show member pathways
12.85 KRAS HRAS ERBB2 EGFR CCND1
11
Show member pathways
12.81 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
12
Show member pathways
12.76 REL PIK3CA KRAS HRAS EGFR
13
Show member pathways
12.76 PIK3CA KRAS HRAS ERBB2 EGFR CDX2
14
Show member pathways
12.72 UBC REL PIK3CA KRAS HRAS ERBB2
15
Show member pathways
12.7 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
16
Show member pathways
12.63 REL PIK3CA KRAS HRAS EGFR
17
Show member pathways
12.62 REL PIK3CA KRAS HRAS ERBB2 EGFR
18
Show member pathways
12.6 UBC PIK3CA KRAS HRAS
19 12.56 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
20
Show member pathways
12.54 PIK3CA KRAS HRAS ERBB2 EGFR
21
Show member pathways
12.53 UBC PIK3CA KRAS HRAS
22
Show member pathways
12.53 KRAS HRAS EGFR CCND1
23
Show member pathways
12.52 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
24
Show member pathways
12.5 REL PIK3CA KRAS HRAS ERBB2 CCND1
25
Show member pathways
12.48 REL PIK3CA KRAS HRAS
26
Show member pathways
12.47 PIK3CA KRAS HRAS ERBB2 EGFR
27
Show member pathways
12.45 PIK3CA KRAS HRAS EGFR
28
Show member pathways
12.45 PIK3CA HRAS EGFR CCND1
29
Show member pathways
12.45 REL PIK3CA KRAS HRAS
30 12.44 UBC PIK3CA EGFR CTTN
31
Show member pathways
12.44 PIK3CA KRAS HRAS EGFR
32
Show member pathways
12.44 REL PIK3CA KRAS HRAS
33
Show member pathways
12.43 REL PIK3CA HRAS CCND1
34
Show member pathways
12.43 PIK3CA KRAS HRAS ERBB2 EGFR
35
Show member pathways
12.38 REL KRAS HRAS EGFR
36 12.37 PIK3CA KRAS HRAS CCND1
37
Show member pathways
12.36 REL PIK3CA HRAS CCND1
38
Show member pathways
12.36 PIK3CA HRAS ERBB2 EGFR CCND1
39 12.34 REL PIK3CA KRAS HRAS CCND1
40
Show member pathways
12.31 UBC PIK3CA KRAS HRAS
41
Show member pathways
12.3 PIK3CA KRAS HRAS EGFR
42 12.27 PIK3CA KRAS HRAS CTTN
43
Show member pathways
12.27 PIK3CA HRAS EGFR CCND1
44
Show member pathways
12.27 REL PIK3CA HRAS ERBB2 EGFR CCND1
45
Show member pathways
12.26 UBC REL HRAS EGFR
46
Show member pathways
12.26 PIK3CA KRAS HRAS ERBB2 EGFR CCND1
47
Show member pathways
12.25 REL PIK3CA KRAS HRAS
48
Show member pathways
12.25 UBC PIK3CA KRAS HRAS ERBB2 EGFR
49
Show member pathways
12.24 REL PIK3CA KRAS HRAS
50 12.22 KRAS HRAS ERBB2 EGFR

GO Terms for Ethmoid Sinus Adenocarcinoma

Cellular components related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 UBC SRI REL PIK3CA LGALS4 KRAS

Biological processes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 UBC PIK3CA KRAS CCND1
2 MAPK cascade GO:0000165 9.78 KRAS HRAS ERBB2 EGFR
3 positive regulation of cell proliferation GO:0008284 9.73 KRAS HRAS ERBB2 EGFR CDX2 CCND1
4 positive regulation of epithelial cell proliferation GO:0050679 9.61 HRAS ERBB2 EGFR
5 positive regulation of protein phosphorylation GO:0001934 9.55 KRAS HRAS ERBB2 EGFR CCND1
6 ERBB2 signaling pathway GO:0038128 9.5 PIK3CA ERBB2 EGFR
7 response to isolation stress GO:0035900 9.46 KRAS HRAS
8 negative regulation of ERBB signaling pathway GO:1901185 9.4 ERBB2 EGFR
9 response to UV-A GO:0070141 9.37 EGFR CCND1
10 positive regulation of MAP kinase activity GO:0043406 9.26 KRAS HRAS ERBB2 EGFR
11 liver development GO:0001889 9.02 PIK3CA KRAS HRAS EGFR CCND1

Molecular functions related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 UBC SRI REL PIK3CA LGALS4 KRAS
2 protein-containing complex binding GO:0044877 9.02 KRAS HRAS EGFR CLU CCND1

Sources for Ethmoid Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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