MCID: ETH008
MIFTS: 36

Ethmoid Sinus Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Ethmoid Sinus Cancer

MalaCards integrated aliases for Ethmoid Sinus Cancer:

Name: Ethmoid Sinus Cancer 12 15
Neoplasm of Ethmoidal Sinus 12 73
Malignant Neoplasm of Ethmoidal Sinus 12
Malignant Tumor of Ethmoidal Sinus 12
Malignant Tumor of Ethmoid Sinus 12
Ethmoidal Sinus Neoplasm 12
Tumor of Ethmoidal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1363 DOID:1364
ICD10 33 C31.1
ICD9CM 35 160.3
NCIt 50 C3541 C4416

Summaries for Ethmoid Sinus Cancer

MalaCards based summary : Ethmoid Sinus Cancer, also known as neoplasm of ethmoidal sinus, is related to ethmoid sinus adenocarcinoma and squamous cell carcinoma of the oral tongue. An important gene associated with Ethmoid Sinus Cancer is CTTN (Cortactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Focal Adhesion. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Ethmoid Sinus Cancer

Diseases related to Ethmoid Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 ethmoid sinus adenocarcinoma 25.6 CCND1 CTTN CXCL11 EGFR GGT1 GGT2
2 squamous cell carcinoma of the oral tongue 10.4 CCND1 PIK3CA
3 apocrine adenoma 10.4 HRAS PIK3CA
4 prostate adenoid cystic carcinoma 10.4 HRAS PIK3CA
5 hemimegalencephaly 10.3 CCND1 PIK3CA
6 sinus cancer 10.3
7 aggressive digital papillary adenocarcinoma 10.3 HRAS PIK3CA
8 nasal cavity adenocarcinoma 10.2 CXCL11 HRAS
9 nevus, epidermal 10.2 HRAS PIK3CA
10 prostate squamous cell carcinoma 10.2 HRAS PIK3CA
11 breast squamous cell carcinoma 10.2 EGFR PIK3CA
12 paronychia 10.0 EGFR HRAS
13 brain stem glioma 9.9 EGFR PIK3CA
14 cyclosporiasis 9.8 GGT1 GGT2
15 bladder urothelial carcinoma 9.8 CCND1 HRAS PIK3CA
16 algoneurodystrophy 9.8 GGT1 GGT2
17 adenoid cystic carcinoma 9.8 CCND1 HRAS PIK3CA
18 hidradenocarcinoma 9.8 CCND1 EGFR
19 spinal chordoma 9.8 EGFR PIK3CA
20 hepatic tuberculosis 9.8 GGT1 GGT2
21 estrogen-receptor positive breast cancer 9.8 CCND1 EGFR PIK3CA
22 bile duct carcinoma 9.7 CCND1 EGFR PIK3CA
23 lung adenoid cystic carcinoma 9.7 EGFR HRAS PIK3CA
24 acneiform dermatitis 9.7 EGFR HRAS PIK3CA
25 adenosquamous cell lung carcinoma 9.7 EGFR HRAS PIK3CA
26 malignant ovarian surface epithelial-stromal neoplasm 9.7 EGFR HRAS PIK3CA
27 ovary epithelial cancer 9.7 EGFR HRAS PIK3CA
28 uterine carcinosarcoma 9.7 EGFR HRAS PIK3CA
29 adamantinoma of long bones 9.6 CCND1 EGFR PIK3CA
30 cataract 31, multiple types 9.6 GGT1 GGT2
31 pancreatic cystadenocarcinoma 9.6 GGT1 GGT2
32 penile cancer 9.6 CCND1 EGFR HRAS
33 pre-malignant neoplasm 9.5 CCND1 EGFR
34 cell type cancer 9.5 CCND1 EGFR HRAS
35 lung squamous cell carcinoma 9.5 EGFR HRAS PIK3CA
36 glioblastoma multiforme 9.5 CCND1 EGFR PIK3CA
37 brain cancer 9.3 EGFR HRAS PIK3CA
38 periampullary adenoma 9.3 GGT1 GGT2 HRAS
39 colloid carcinoma of the pancreas 9.2 GGT1 GGT2 HRAS
40 female reproductive organ cancer 9.2 CCND1 EGFR HRAS PIK3CA
41 respiratory system cancer 9.2 CCND1 EGFR HRAS PIK3CA
42 gastrointestinal system cancer 9.2 CCND1 EGFR HRAS PIK3CA
43 pancreas adenocarcinoma 9.2 CCND1 EGFR HRAS PIK3CA
44 adenocarcinoma 9.1 CCND1 EGFR HRAS PIK3CA
45 lung cancer susceptibility 3 9.1 CCND1 EGFR HRAS PIK3CA
46 gastric adenocarcinoma 9.1 CCND1 EGFR HRAS PIK3CA
47 nasopharyngeal carcinoma 9.1 CCND1 EGFR HRAS PIK3CA
48 glioblastoma 9.1 CCND1 EGFR HRAS PIK3CA
49 esophageal cancer 9.0 CCND1 EGFR HRAS PIK3CA
50 granulomatous hepatitis 9.0 GGT1 GGT2

Graphical network of the top 20 diseases related to Ethmoid Sinus Cancer:



Diseases related to Ethmoid Sinus Cancer

Symptoms & Phenotypes for Ethmoid Sinus Cancer

GenomeRNAi Phenotypes related to Ethmoid Sinus Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 EGFR HRAS PIK3CA
2 Decreased viability GR00221-A-1 9.47 EGFR HRAS PIK3CA
3 Decreased viability GR00221-A-2 9.47 HRAS PIK3CA
4 Decreased viability GR00221-A-3 9.47 HRAS
5 Decreased viability GR00221-A-4 9.47 EGFR PIK3CA
6 Decreased viability GR00402-S-2 9.47 EGFR HRAS PIK3CA

MGI Mouse Phenotypes related to Ethmoid Sinus Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 HRAS NDUFS3 CCND1 PIK3CA CTTN SNCA
2 growth/size/body region MP:0005378 9.92 HRAS NDUFS3 CCND1 PIK3CA CTTN SNCA
3 endocrine/exocrine gland MP:0005379 9.85 GGT1 HRAS CCND1 PIK3CA SNCA EGFR
4 integument MP:0010771 9.73 GGT1 HRAS CCND1 PIK3CA SNCA EGFR
5 no phenotypic analysis MP:0003012 9.55 HRAS PIK3CA CTTN SNCA EGFR
6 reproductive system MP:0005389 9.43 GGT1 CCND1 PIK3CA CTTN SNCA EGFR
7 skeleton MP:0005390 9.1 GGT1 HRAS CCND1 PIK3CA SNCA EGFR

Drugs & Therapeutics for Ethmoid Sinus Cancer

Search Clinical Trials , NIH Clinical Center for Ethmoid Sinus Cancer

Genetic Tests for Ethmoid Sinus Cancer

Anatomical Context for Ethmoid Sinus Cancer

Publications for Ethmoid Sinus Cancer

Articles related to Ethmoid Sinus Cancer:

(show all 11)
# Title Authors Year
1
Dosimetric comparison between coplanar and non coplanar field radiotherapy for ethmoid sinus cancer. ( 17877793 )
2007
2
Comparison of dose-volume histograms of IMRT treatment plans for ethmoid sinus cancer computed by advanced treatment planning systems including Monte Carlo. ( 17113671 )
2006
3
Subtotal nasal reconstruction for ethmoid sinus cancer defect using a fibula osteocutaneous free flap. ( 16894490 )
2006
4
Ethmoid sinus cancer: results of treatment with surgery and combined therapy. ( 15768822 )
2004
5
Report of a study on IMRT planning strategies for ethmoid sinus cancer. ( 12386789 )
2002
6
Intensity modulation technique using the complementary boost-fields for ethmoid sinus cancer. ( 12109830 )
2002
7
An implementation strategy for IMRT of ethmoid sinus cancer with bilateral sparing of the optic pathways. ( 11567805 )
2001
8
Ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. ( 9607352 )
1998
9
Factors influencing survival in ethmoid sinus cancer. ( 1313248 )
1992
10
Transcranial resection of ethmoid sinus cancer involving the anterior skull base. ( 17170870 )
1992
11
Ethmoid sinus cancer. ( 5066624 )
1972

Variations for Ethmoid Sinus Cancer

Expression for Ethmoid Sinus Cancer

Search GEO for disease gene expression data for Ethmoid Sinus Cancer.

Pathways for Ethmoid Sinus Cancer

Pathways related to Ethmoid Sinus Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 CCND1 EGFR HRAS PIK3CA
2
Show member pathways
12.76 CCND1 EGFR HRAS PIK3CA
3
Show member pathways
12.74 CCND1 CXCL11 HRAS PIK3CA
4
Show member pathways
12.72 CCND1 EGFR HRAS PIK3CA
5 12.68 CCND1 EGFR HRAS PIK3CA
6
Show member pathways
12.61 CCND1 EGFR HRAS PIK3CA
7
Show member pathways
12.6 CCND1 EGFR HRAS PIK3CA
8
Show member pathways
12.5 CCND1 EGFR HRAS PIK3CA
9
Show member pathways
12.42 CCND1 EGFR HRAS PIK3CA
10
Show member pathways
12.33 CCND1 EGFR HRAS PIK3CA
11 12.29 CCND1 EGFR HRAS PIK3CA
12
Show member pathways
12.28 EGFR HRAS PIK3CA
13
Show member pathways
12.24 CCND1 EGFR HRAS PIK3CA
14
Show member pathways
12.21 CCND1 HRAS PIK3CA
15
Show member pathways
12.2 EGFR HRAS PIK3CA
16 12.17 CCND1 HRAS PIK3CA
17 12.04 CCND1 HRAS PIK3CA
18
Show member pathways
12.01 EGFR HRAS PIK3CA
19
Show member pathways
11.99 CCND1 EGFR HRAS PIK3CA
20 11.92 EGFR HRAS PIK3CA
21
Show member pathways
11.91 CCND1 EGFR HRAS
22
Show member pathways
11.88 CCND1 HRAS PIK3CA
23 11.86 CCND1 EGFR HRAS PIK3CA
24 11.83 CCND1 HRAS PIK3CA
25 11.82 CCND1 HRAS PIK3CA
26 11.8 CCND1 EGFR HRAS
27
Show member pathways
11.78 EGFR HRAS PIK3CA
28 11.77 EGFR HRAS PIK3CA
29 11.73 CCND1 HRAS PIK3CA
30
Show member pathways
11.72 CCND1 EGFR HRAS PIK3CA
31
Show member pathways
11.68 EGFR HRAS PIK3CA
32 11.52 CCND1 EGFR HRAS
33 11.45 EGFR HRAS PIK3CA
34
Show member pathways
11.4 CCND1 EGFR HRAS PIK3CA
35 11.36 CTTN EGFR HRAS
36 11.32 CCND1 CTTN EGFR HRAS PIK3CA
37 11.3 HRAS PIK3CA
38 11.25 CXCL11 PIK3CA
39 11.24 EGFR PIK3CA
40 11.23 CTTN PIK3CA
41 11.21 CCND1 PIK3CA
42 11.18 EGFR HRAS
43 11.18 HRAS PIK3CA
44 11.14 HRAS PIK3CA
45 11.12 EGFR PIK3CA
46
Show member pathways
11.1 EGFR HRAS
47 11.07 EGFR PIK3CA
48 11.05 GGT1 GGT2
49 11.03 GGT1 GGT2
50 11.03 CCND1 HRAS

GO Terms for Ethmoid Sinus Cancer

Cellular components related to Ethmoid Sinus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.92 EGFR GGT2 HRAS SNCA

Biological processes related to Ethmoid Sinus Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.7 CCND1 EGFR HRAS
2 negative regulation of neuron apoptotic process GO:0043524 9.67 HRAS PIK3CA SNCA
3 membrane organization GO:0061024 9.65 CTTN EGFR SNCA
4 liver regeneration GO:0097421 9.55 CCND1 EGFR
5 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.54 CXCL11 SNCA
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS SNCA
7 liver development GO:0001889 9.5 CCND1 EGFR PIK3CA
8 zymogen activation GO:0031638 9.46 GGT1 GGT2
9 response to magnesium ion GO:0032026 9.43 CCND1 SNCA
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 EGFR PIK3CA SNCA
11 glutathione catabolic process GO:0006751 9.4 GGT1 GGT2
12 leukotriene D4 biosynthetic process GO:1901750 9.37 GGT1 GGT2
13 epidermal growth factor receptor signaling pathway GO:0007173 9.33 EGFR HRAS PIK3CA
14 response to UV-A GO:0070141 8.96 CCND1 EGFR
15 ERBB2 signaling pathway GO:0038128 8.8 EGFR HRAS PIK3CA

Molecular functions related to Ethmoid Sinus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Ethmoid Sinus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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